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Conserved domains on  [gi|119574787|gb|EAW54402|]
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eukaryotic translation initiation factor 4E binding protein 2, isoform CRA_a [Homo sapiens]

Protein Classification

eIF_4EBP domain-containing protein( domain architecture ID 10527201)

eIF_4EBP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF_4EBP pfam05456
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP); This family consists of ...
 11-120 6.41e-66

Eukaryotic translation initiation factor 4E binding protein (EIF4EBP); This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognized by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F.


:

Pssm-ID: 461656  Cd Length: 110  Bit Score: 194.37  E-value: 6.41e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574787   11 PSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGTLIED 90
Cdd:pfam05456   1 QTQSRAIPSRRVLINDASQLPDDYSTTPGGTLFSTTPGGTRIIYDRKFLLNCRNSPLARTPPSNLPNIPGVTSPGKKPIP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 119574787   91 SKVEVNNLNNLNNHDRKHAVGDDAQFEMDI 120
Cdd:pfam05456  81 KEKENNPASTKENEEEKKKDGEDEQFEMDI 110
 
Name Accession Description Interval E-value
eIF_4EBP pfam05456
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP); This family consists of ...
 11-120 6.41e-66

Eukaryotic translation initiation factor 4E binding protein (EIF4EBP); This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognized by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F.


Pssm-ID: 461656  Cd Length: 110  Bit Score: 194.37  E-value: 6.41e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574787   11 PSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGTLIED 90
Cdd:pfam05456   1 QTQSRAIPSRRVLINDASQLPDDYSTTPGGTLFSTTPGGTRIIYDRKFLLNCRNSPLARTPPSNLPNIPGVTSPGKKPIP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 119574787   91 SKVEVNNLNNLNNHDRKHAVGDDAQFEMDI 120
Cdd:pfam05456  81 KEKENNPASTKENEEEKKKDGEDEQFEMDI 110
 
Name Accession Description Interval E-value
eIF_4EBP pfam05456
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP); This family consists of ...
 11-120 6.41e-66

Eukaryotic translation initiation factor 4E binding protein (EIF4EBP); This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognized by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F.


Pssm-ID: 461656  Cd Length: 110  Bit Score: 194.37  E-value: 6.41e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574787   11 PSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGTLIED 90
Cdd:pfam05456   1 QTQSRAIPSRRVLINDASQLPDDYSTTPGGTLFSTTPGGTRIIYDRKFLLNCRNSPLARTPPSNLPNIPGVTSPGKKPIP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 119574787   91 SKVEVNNLNNLNNHDRKHAVGDDAQFEMDI 120
Cdd:pfam05456  81 KEKENNPASTKENEEEKKKDGEDEQFEMDI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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