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Conserved domains on  [gi|1476486185|sp|D9J142|]
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RecName: Full=Inactive lysozyme 1A; Flags: Precursor

Protein Classification

LYZ_C_invert domain-containing protein( domain architecture ID 13014106)

LYZ_C_invert domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 20-140 1.29e-63

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


:

Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 190.13  E-value: 1.29e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185  20 KTFTRCSLAKEVYALGVPKSELPQWTCIAEHGSSYRTNVVGPTNSNGSNDYGIFQINNYYWCQPANGrfSYNECKLSCND 99
Cdd:cd16899     1 KIFTRCELARELRKLGVPRSQLANWVCLAEHESSFNTTAVGGPNSDGSGDYGLFQINDKYWCSPGGG--SGNGCNVKCED 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1476486185 100 LLTDNISNSVKCARKIKSQQGWTAWSTWK-YCSG-SLPSINDC 140
Cdd:cd16899    79 LLDDDISDDVKCAKKIYKEQGFNAWVGWKnKCKGkNLPSYSDC 121
 
Name Accession Description Interval E-value
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 20-140 1.29e-63

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 190.13  E-value: 1.29e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185  20 KTFTRCSLAKEVYALGVPKSELPQWTCIAEHGSSYRTNVVGPTNSNGSNDYGIFQINNYYWCQPANGrfSYNECKLSCND 99
Cdd:cd16899     1 KIFTRCELARELRKLGVPRSQLANWVCLAEHESSFNTTAVGGPNSDGSGDYGLFQINDKYWCSPGGG--SGNGCNVKCED 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1476486185 100 LLTDNISNSVKCARKIKSQQGWTAWSTWK-YCSG-SLPSINDC 140
Cdd:cd16899    79 LLDDDISDDVKCAKKIYKEQGFNAWVGWKnKCKGkNLPSYSDC 121
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
20-141 9.44e-50

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 155.14  E-value: 9.44e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185   20 KTFTRCSLAKEVYAL---GVPKSELPQWTCIAEHGSSYRTNVVGPtNSNGSNDYGIFQINNYYWCQPANGRFSYNECKLS 96
Cdd:smart00263   1 KVFTRCELARELKRLgldGYRGISLANWVCLAFHESGYNTQATNY-NNGGSTDYGIFQINSKYWCNDGKTPGSVNACGIS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1476486185   97 CNDLLTDNISNSVKCARKIKSQQGWTAWSTWK-YCSGS--LPSINDCF 141
Cdd:smart00263  80 CSKLLDDDITDDVKCAKKIVSDQGIDAWVAWKnHCQGEdlSQWIRGCG 127
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-140 2.96e-47

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 148.72  E-value: 2.96e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185  20 KTFTRCSLAKEVYALGVPKS---ELPQWTCIAEHGSSYRTNVVGptNSNGSNDYGIFQINNYYWCQPANGRFSYNECKLS 96
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYrgiSLAEWVCLAFHESGYDTQAIV--YNNGSTDYGIFQINDKYWCKDGKTPQSVNICGIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1476486185  97 CNDLLTDNISNSVKCARKIKSQQGWTAWSTWK-YCSGSLPSINDC 140
Cdd:pfam00062  79 CDKLLDDDITDDIMCAKKILDPQGIDAWLAWKpHCSEDLEQWIGC 123
 
Name Accession Description Interval E-value
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 20-140 1.29e-63

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 190.13  E-value: 1.29e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185  20 KTFTRCSLAKEVYALGVPKSELPQWTCIAEHGSSYRTNVVGPTNSNGSNDYGIFQINNYYWCQPANGrfSYNECKLSCND 99
Cdd:cd16899     1 KIFTRCELARELRKLGVPRSQLANWVCLAEHESSFNTTAVGGPNSDGSGDYGLFQINDKYWCSPGGG--SGNGCNVKCED 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1476486185 100 LLTDNISNSVKCARKIKSQQGWTAWSTWK-YCSG-SLPSINDC 140
Cdd:cd16899    79 LLDDDISDDVKCAKKIYKEQGFNAWVGWKnKCKGkNLPSYSDC 121
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
20-141 9.44e-50

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 155.14  E-value: 9.44e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185   20 KTFTRCSLAKEVYAL---GVPKSELPQWTCIAEHGSSYRTNVVGPtNSNGSNDYGIFQINNYYWCQPANGRFSYNECKLS 96
Cdd:smart00263   1 KVFTRCELARELKRLgldGYRGISLANWVCLAFHESGYNTQATNY-NNGGSTDYGIFQINSKYWCNDGKTPGSVNACGIS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1476486185   97 CNDLLTDNISNSVKCARKIKSQQGWTAWSTWK-YCSGS--LPSINDCF 141
Cdd:smart00263  80 CSKLLDDDITDDVKCAKKIVSDQGIDAWVAWKnHCQGEdlSQWIRGCG 127
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-140 2.96e-47

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 148.72  E-value: 2.96e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185  20 KTFTRCSLAKEVYALGVPKS---ELPQWTCIAEHGSSYRTNVVGptNSNGSNDYGIFQINNYYWCQPANGRFSYNECKLS 96
Cdd:pfam00062   1 KQFTRCELARELKKLGMDGYrgiSLAEWVCLAFHESGYDTQAIV--YNNGSTDYGIFQINDKYWCKDGKTPQSVNICGIS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1476486185  97 CNDLLTDNISNSVKCARKIKSQQGWTAWSTWK-YCSGSLPSINDC 140
Cdd:pfam00062  79 CDKLLDDDITDDIMCAKKILDPQGIDAWLAWKpHCSEDLEQWIGC 123
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 20-140 5.90e-34

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 114.97  E-value: 5.90e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185  20 KTFTRCSLAKEVYAL-GVPKSELPQWTCIAEHGSSYRTNVVGpTNSNGSNDYGIFQINNYYWCQPANGRFSYNECKLSCN 98
Cdd:cd00119     1 KVFTRCELARLLKDIgGYGGISLPNWVCLMKHESGYDTQATN-ENNNGSTDYGLFQINSRYWCKDGQTPGARNICDISCS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1476486185  99 DLLTDNISNSVKCARKIKSQQGWTAWSTWK-YCSGSLPSINDC 140
Cdd:cd00119    80 KLLTDDITDAIMCAKKIVDDKGIDAWVAWKnHCQNKLRQYVSC 122
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 20-133 1.30e-31

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 109.28  E-value: 1.30e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185  20 KTFTRCSLAKEVYALGVPKSE---LPQWTCIAEHGSSYRTNVVGPtNSNGSNDYGIFQINNYYWCQPANGRfSYNECKLS 96
Cdd:cd16897     1 KIFSRCELARILKRGGLDGYRgysLANWVCLAYYESGFNTRATNE-NPDGSTDYGIFQINSRYWCNDGKTP-SKNLCHIS 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1476486185  97 CNDLLTDNISNSVKCARKI-KSQQGWTAWSTWK-YCSGS 133
Cdd:cd16897    79 CSDLLNDDITDDIKCAKKIvKDPQGMGAWVAWRlHCEGR 117
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 22-134 8.29e-23

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 86.72  E-value: 8.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185  22 FTRCSLA---KEVYALGVPKSELPQWTCIAEHGSSYRTNVVgpTNSNGSNDYGIFQINNYYWCQPANGRFSYNECKLSCN 98
Cdd:cd16898     3 FTKCELSqilKEHGLDGFNGISLPEWICVTFHTSGYDTQAL--VYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGISCS 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1476486185  99 DLLTDNISNSVKCARKI-KSQQGWTAWSTWK-YCSGSL 134
Cdd:cd16898    81 KLLDDDITDDIACAKKIlAIPKGIDYWKAHKpFCREDL 118
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 47-76 2.70e-03

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 35.20  E-value: 2.70e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1476486185  47 IAEHGSSYRTNVVGPtNSNGSNDYGIFQIN 76
Cdd:cd13400    11 IAKVESGFNPNAINR-NKNGSYDIGLMQIN 39
SLT_3 pfam18896
Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla ...
 28-126 3.15e-03

Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla radiation bacteria. The domain contains several conserved cysteine and histidine residues suggesting that it may bind to zinc.


Pssm-ID: 436815 [Multi-domain]  Cd Length: 89  Bit Score: 34.69  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476486185  28 AKEVYALGVPKSELPQWTCIAEHGSSYRTNVVG-PTNSNGSNDYGIFQINNYYwcqpANGRFSYNECklscndlLTDNIS 106
Cdd:pfam18896   1 AALARAAGFTGDDAVTAVAVAMAESGGDPSAVGdLANTKGSPSRGLWQINSLA----HPEVTGPDAC-------AYDPQC 69

                          90       100
                  ....*....|....*....|.
gi 1476486185 107 NSvKCARKIKSQ-QGWTAWST 126
Cdd:pfam18896  70 NA-KAAYAISSGgTNWSPWST 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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