|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15445 |
PRK15445 |
arsenical efflux pump membrane protein ArsB; |
5-430 |
0e+00 |
|
arsenical efflux pump membrane protein ArsB;
Pssm-ID: 185342 Cd Length: 427 Bit Score: 663.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 5 LATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIH 84
Cdd:PRK15445 2 LAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIVWNATLTFIAIIIISLLLDEAGFFEWAALH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 85 MLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNI 164
Cdd:PRK15445 82 VARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLALGFSKKATLAFVMAAGFIADTASLPLVVSNLVNI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 165 ISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDANHIKKPKDAINDLKLFKISWIVLVILLFGYLISE 244
Cdd:PRK15445 162 VSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDLELLKEPASAIKDPALFKLGWIVLALLLVGYFVLE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 245 FTKIPVSIFTGIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFSTIL 324
Cdd:PRK15445 242 PLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLADQGLFAATL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 325 GMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTY 404
Cdd:PRK15445 322 GTGFLAAFLSSVMNNMPTVLIGALAIDGSNATGVIKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGYY 401
|
410 420
....*....|....*....|....*.
gi 995435237 405 FKTGITITIPVLFITLLGLYLTLIIF 430
Cdd:PRK15445 402 FKVGIIITLPVLLVTLLALALRLSLF 427
|
|
| 2a45 |
TIGR00935 |
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a ... |
5-429 |
0e+00 |
|
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a highly hydrophobic integral membrane protein involved in transport processes used to protect cells from arsenite (or antimonite). Members of the seed alignment were selected by adjacency to the ATPase subunit ArsA that energizes the transport. [Cellular processes, Detoxification, Transport and binding proteins, Other]
Pssm-ID: 213571 Cd Length: 426 Bit Score: 565.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 5 LATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIH 84
Cdd:TIGR00935 2 LAVLIFLLTLVLVIWQPKGLGIGWSATIGAVLALLSGVVSFGDVPVVTGIVWNATLTFVAIIIISLILDEIGFFEWAALH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 85 MLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNI 164
Cdd:TIGR00935 82 MARWAKGNGRKMFIYISLLGAIVAALFANDGAALILTPIVLAMVRALGFDEAAVLPFIMASGFIADTTSLPLIVSNLVNI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 165 ISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDANHIKKPKDAINDLKLFKISWIVLVILLFGYLISE 244
Cdd:TIGR00935 162 VSADFFGIGFNEYAAVMIPPNIFALIASILVLYLYFRKDIPARYDVSQLREPKEAIKDQKLFKFSWVVLALLLVGYFGSE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 245 FTKIPVSIFTGIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFSTIL 324
Cdd:TIGR00935 242 FLNIPVSFVAATIALIFLVVAAKSHAVDTRKVIKGAPWNIVVFSLGMYLVVYGLRNVGLTDLLAGVLDYFADQGLFVATM 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 325 GMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTY 404
Cdd:TIGR00935 322 GMGFLAAFLSSIMNNMPTVLINALSIDGSNATGVMKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGYY 401
|
410 420
....*....|....*....|....*
gi 995435237 405 FKTGITITIPVLFITLLGLYLTLII 429
Cdd:TIGR00935 402 FKVGIVITVPVLFITLAGLYLRLSI 426
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
5-424 |
4.33e-156 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 447.48 E-value: 4.33e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 5 LATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIH 84
Cdd:cd01118 1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGIVWDVTLTLIGVILLSLLLDEEGFFEWVAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 85 MLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNI 164
Cdd:cd01118 81 AARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLVNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 165 ISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDANHIKKPKDAINDLKLFKISWIVLVILLFGYLISE 244
Cdd:cd01118 161 VTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLETASVKKPSLAIKDPLLFGLAWTLLVLLVVSAFGVD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 245 FTKIPVSIFTGIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFSTIL 324
Cdd:cd01118 241 ILLIPPSFIAGVLALIFLLLARRGGAINPLKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQGLLAAIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 325 GMGFISAFLSSIMNNMPTVLIDAIAIGQsnvhGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTY 404
Cdd:cd01118 321 GVGLLAAFLSNVMNNLPAVLIGALALAA----GHAPEALVYANLIGVDLGPKLTPIGSLATLLWLHVLRRKGIRVSWGYY 396
|
410 420
....*....|....*....|
gi 995435237 405 FKTGITITIPVLFITLLGLY 424
Cdd:cd01118 397 LKVGLIVTPPVLVVTLAALI 416
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
2-428 |
1.19e-104 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 316.30 E-value: 1.19e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 2 MTTLATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVtgIVWNATLTFVSVILISLILDKIGFFEWS 81
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA--IDWNTILFLLGMMIIVAILDESGFFEWL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 82 AIHMLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRaifPFIIASGFIADTTSLPLIVSNL 161
Cdd:COG1055 79 AIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPV---PFLIAIVFAANIGGAATPIGNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 162 VNIISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDanHIKKPKDAINDLKLFKISWIVLVILLFGYL 241
Cdd:COG1055 156 TNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPD--LEDDPKEAIKDRRLLRISLLVLALLLVGFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 242 ISEFTKIPVSIFTGIIAFIFLMLARksnaVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFS 321
Cdd:COG1055 234 LHSFLGLPPALIALLGAAVLLLLAR----VDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 322 TILGMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLkEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISW 401
Cdd:COG1055 310 AALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNP-EPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISF 388
|
410 420
....*....|....*....|....*..
gi 995435237 402 GTYFKTGITITIPVLFITLLGLYLTLI 428
Cdd:COG1055 389 GEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| ArsB |
pfam02040 |
Arsenical pump membrane protein; |
5-427 |
2.42e-99 |
|
Arsenical pump membrane protein;
Pssm-ID: 460426 Cd Length: 423 Bit Score: 303.05 E-value: 2.42e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 5 LATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIH 84
Cdd:pfam02040 6 FALFIFLLILQLKILQIGNLACGGAACAGAAGALIAGDVLFHDGITVNAILAFAAIAFIAIILDNIGFDEIAAFEMAAAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 85 MLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNI 164
Cdd:pfam02040 86 KAKAAKGFGVRMFLGAILAAAFAAAGAALDGAAIILAMIRAAHFNAKHFFEFIIAPFFIADGFIADFTSLNFVNINLADI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 165 ISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDANHIKKPKDAINDLKLFKISWIVLVILLFGYLISE 244
Cdd:pfam02040 166 FHADFFDIAFIDVAPRLFSLLAFIILASIFFLKLFFKKSDLKEVDKPEEAIKDEAIFDLNMFILGLLIIGLFAIEFFAIE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 245 FTKIPVSIFTGIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEyisnyGLFSTIL 324
Cdd:pfam02040 246 FFSIAGSIAAGFIAAAFKIAAQHSKAVHKEAPVAEAFFAIGFFSIGMGVRNAGLRDAGLDDILAAADQ-----AAAAGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 325 GMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTY 404
Cdd:pfam02040 321 FAGFIAAGFIAAILNLIMNMIDALAIAALAIAGMDREALIRAALIGADLGGKDLGIGILAIGLLAHLLSHHGLKHKGGKI 400
|
410 420
....*....|....*....|...
gi 995435237 405 FKTGITITIPVLFITLLGLYLTL 427
Cdd:pfam02040 401 FKGGIFKTGIILLIPLLGITIVG 423
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15445 |
PRK15445 |
arsenical efflux pump membrane protein ArsB; |
5-430 |
0e+00 |
|
arsenical efflux pump membrane protein ArsB;
Pssm-ID: 185342 Cd Length: 427 Bit Score: 663.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 5 LATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIH 84
Cdd:PRK15445 2 LAIAIFLLTLVLVIWQPKGLGIGWSALLGAVLALLTGVVSLGDVPVVWGIVWNATLTFIAIIIISLLLDEAGFFEWAALH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 85 MLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNI 164
Cdd:PRK15445 82 VARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLALGFSKKATLAFVMAAGFIADTASLPLVVSNLVNI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 165 ISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDANHIKKPKDAINDLKLFKISWIVLVILLFGYLISE 244
Cdd:PRK15445 162 VSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDLELLKEPASAIKDPALFKLGWIVLALLLVGYFVLE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 245 FTKIPVSIFTGIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFSTIL 324
Cdd:PRK15445 242 PLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLADQGLFAATL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 325 GMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTY 404
Cdd:PRK15445 322 GTGFLAAFLSSVMNNMPTVLIGALAIDGSNATGVIKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGYY 401
|
410 420
....*....|....*....|....*.
gi 995435237 405 FKTGITITIPVLFITLLGLYLTLIIF 430
Cdd:PRK15445 402 FKVGIIITLPVLLVTLLALALRLSLF 427
|
|
| 2a45 |
TIGR00935 |
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a ... |
5-429 |
0e+00 |
|
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a highly hydrophobic integral membrane protein involved in transport processes used to protect cells from arsenite (or antimonite). Members of the seed alignment were selected by adjacency to the ATPase subunit ArsA that energizes the transport. [Cellular processes, Detoxification, Transport and binding proteins, Other]
Pssm-ID: 213571 Cd Length: 426 Bit Score: 565.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 5 LATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIH 84
Cdd:TIGR00935 2 LAVLIFLLTLVLVIWQPKGLGIGWSATIGAVLALLSGVVSFGDVPVVTGIVWNATLTFVAIIIISLILDEIGFFEWAALH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 85 MLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNI 164
Cdd:TIGR00935 82 MARWAKGNGRKMFIYISLLGAIVAALFANDGAALILTPIVLAMVRALGFDEAAVLPFIMASGFIADTTSLPLIVSNLVNI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 165 ISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDANHIKKPKDAINDLKLFKISWIVLVILLFGYLISE 244
Cdd:TIGR00935 162 VSADFFGIGFNEYAAVMIPPNIFALIASILVLYLYFRKDIPARYDVSQLREPKEAIKDQKLFKFSWVVLALLLVGYFGSE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 245 FTKIPVSIFTGIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFSTIL 324
Cdd:TIGR00935 242 FLNIPVSFVAATIALIFLVVAAKSHAVDTRKVIKGAPWNIVVFSLGMYLVVYGLRNVGLTDLLAGVLDYFADQGLFVATM 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 325 GMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTY 404
Cdd:TIGR00935 322 GMGFLAAFLSSIMNNMPTVLINALSIDGSNATGVMKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGYY 401
|
410 420
....*....|....*....|....*
gi 995435237 405 FKTGITITIPVLFITLLGLYLTLII 429
Cdd:TIGR00935 402 FKVGIVITVPVLFITLAGLYLRLSI 426
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
5-424 |
4.33e-156 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 447.48 E-value: 4.33e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 5 LATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIH 84
Cdd:cd01118 1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGIVWDVTLTLIGVILLSLLLDEEGFFEWVAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 85 MLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNI 164
Cdd:cd01118 81 AARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLVNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 165 ISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDANHIKKPKDAINDLKLFKISWIVLVILLFGYLISE 244
Cdd:cd01118 161 VTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLETASVKKPSLAIKDPLLFGLAWTLLVLLVVSAFGVD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 245 FTKIPVSIFTGIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFSTIL 324
Cdd:cd01118 241 ILLIPPSFIAGVLALIFLLLARRGGAINPLKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQGLLAAIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 325 GMGFISAFLSSIMNNMPTVLIDAIAIGQsnvhGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTY 404
Cdd:cd01118 321 GVGLLAAFLSNVMNNLPAVLIGALALAA----GHAPEALVYANLIGVDLGPKLTPIGSLATLLWLHVLRRKGIRVSWGYY 396
|
410 420
....*....|....*....|
gi 995435237 405 FKTGITITIPVLFITLLGLY 424
Cdd:cd01118 397 LKVGLIVTPPVLVVTLAALI 416
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
2-428 |
1.19e-104 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 316.30 E-value: 1.19e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 2 MTTLATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVtgIVWNATLTFVSVILISLILDKIGFFEWS 81
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA--IDWNTILFLLGMMIIVAILDESGFFEWL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 82 AIHMLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRaifPFIIASGFIADTTSLPLIVSNL 161
Cdd:COG1055 79 AIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPV---PFLIAIVFAANIGGAATPIGNP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 162 VNIISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDanHIKKPKDAINDLKLFKISWIVLVILLFGYL 241
Cdd:COG1055 156 TNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPD--LEDDPKEAIKDRRLLRISLLVLALLLVGFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 242 ISEFTKIPVSIFTGIIAFIFLMLARksnaVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFS 321
Cdd:COG1055 234 LHSFLGLPPALIALLGAAVLLLLAR----VDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 322 TILGMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLkEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISW 401
Cdd:COG1055 310 AALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNP-EPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISF 388
|
410 420
....*....|....*....|....*..
gi 995435237 402 GTYFKTGITITIPVLFITLLGLYLTLI 428
Cdd:COG1055 389 GEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| ArsB |
pfam02040 |
Arsenical pump membrane protein; |
5-427 |
2.42e-99 |
|
Arsenical pump membrane protein;
Pssm-ID: 460426 Cd Length: 423 Bit Score: 303.05 E-value: 2.42e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 5 LATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEVTGIVWNATLTFVSVILISLILDKIGFFEWSAIH 84
Cdd:pfam02040 6 FALFIFLLILQLKILQIGNLACGGAACAGAAGALIAGDVLFHDGITVNAILAFAAIAFIAIILDNIGFDEIAAFEMAAAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 85 MLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLPLIVSNLVNI 164
Cdd:pfam02040 86 KAKAAKGFGVRMFLGAILAAAFAAAGAALDGAAIILAMIRAAHFNAKHFFEFIIAPFFIADGFIADFTSLNFVNINLADI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 165 ISADYFNISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDANHIKKPKDAINDLKLFKISWIVLVILLFGYLISE 244
Cdd:pfam02040 166 FHADFFDIAFIDVAPRLFSLLAFIILASIFFLKLFFKKSDLKEVDKPEEAIKDEAIFDLNMFILGLLIIGLFAIEFFAIE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 245 FTKIPVSIFTGIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEyisnyGLFSTIL 324
Cdd:pfam02040 246 FFSIAGSIAAGFIAAAFKIAAQHSKAVHKEAPVAEAFFAIGFFSIGMGVRNAGLRDAGLDDILAAADQ-----AAAAGGI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 325 GMGFISAFLSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTY 404
Cdd:pfam02040 321 FAGFIAAGFIAAILNLIMNMIDALAIAALAIAGMDREALIRAALIGADLGGKDLGIGILAIGLLAHLLSHHGLKHKGGKI 400
|
410 420
....*....|....*....|...
gi 995435237 405 FKTGITITIPVLFITLLGLYLTL 427
Cdd:pfam02040 401 FKGGIFKTGIILLIPLLGITIVG 423
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
16-423 |
2.11e-63 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 209.41 E-value: 2.11e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 16 FVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEvtGIVWNATLTFVSVILISLILDKIGFFEWSAIHMLHASKGNGLK 95
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALS--AIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 96 MFvYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRaiFPFIIASGFIADTTSLPLIVSNLVNIISADYFNISFS 175
Cdd:cd00625 79 LL-LLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPP--VPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 176 QYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDAN--HIKKPKDAINDLKLFKISWIVLVILLFGYLiseFTKIPVSIF 253
Cdd:cd00625 156 DFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKltVLAEPLPARPLLKKFLLLALLLLLLFVLLF---FFLIPLGLI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 254 TGIIAFIFLMLARKSnaVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFSTILGMGFISAFL 333
Cdd:cd00625 233 ALLGALLLLLLLVRG--LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 334 SSIMNNMPTVLIDAIAIGQSNVhgmlKEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTYFKTGITITI 413
Cdd:cd00625 311 SNFISNVPTVALLLPIAASLAP----PEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTL 386
|
410
....*....|
gi 995435237 414 PVLFITLLGL 423
Cdd:cd00625 387 LSLVVSLLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
16-366 |
2.28e-34 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 130.90 E-value: 2.28e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 16 FVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEvtGIVWNATLTFVSVILISLILDKIGFFEWSAIHMLHASKGNGLK 95
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALS--GIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 96 MFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSkraIFPFIIASGFIADTTSLPLIVSNLVNIISADYFNISFS 175
Cdd:pfam03600 79 LLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP---PSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 176 QYLSRMIIPNL-FSLLGSLLVLWLYFRKAIPKSFDANHIKKP--KDAINDLKLFKISWIVLVILLFGYLISEftkipvsi 252
Cdd:pfam03600 156 DFGFFMFPPVGvALLLVGLLPLLLIFRKLLPVRKEEEAELEElrKRAIKDKLLLAISALVLALVILGFLLLS-------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 253 ftgIIAFIFLMLARKSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISnyGLFSTILGMGFISAF 332
Cdd:pfam03600 228 ---VLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GLLVALALILWLSAL 302
|
330 340 350
....*....|....*....|....*....|....
gi 995435237 333 LSSIMNNMPTVLIDAIAIGQSNVHGMLKEGLIYA 366
Cdd:pfam03600 303 LSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
28-425 |
7.67e-31 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 122.36 E-value: 7.67e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 28 FTALAGAIVAMITGVVSLTDVFE--VTGIVWNATLTFVSVILISLILDKIGFFEWSAIHMLHASKGNGLKMFVYIILLGA 105
Cdd:cd01116 17 VAALAGALWLVILGLATLSPDLEtiVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 106 VVAAFFANDGSALILTPIVLAMVKNIGfskRAIFPFIIASGFIADTTSLPLIVSNLVNIISADYFNISFSQYLSRMIIPN 185
Cdd:cd01116 97 FLSAFLDNVTTVLLMVPVTIRLCEVLG---LNPVPVLISEVIAANIGGAATLIGDPPNIMIGSAAGLTFNDFLLHMLPSV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 186 LFSLLGSLLVLWLYFRKAIPKSF---DANHIKKPKDAINDLKLFKISWIVLVILLFGYLISEFTKIPVSIFTGIIAFIFL 262
Cdd:cd01116 174 VLALVVTFILLYFLYRNILKAREedvLALAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGVSLGWIALLGALLLL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 263 MLARKsnaVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYISNYGLFSTILGMGFISAFLSSIMNNMP- 341
Cdd:cd01116 254 LLADK---LDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPv 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 342 -TVLIDAIAIGQSNVHGMLkEGLIYANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTYFKTGITITIpvLFITL 420
Cdd:cd01116 331 tATMIPIVKDLASQLGIPL-LPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLKVGFPIML--VSLIL 407
|
....*
gi 995435237 421 LGLYL 425
Cdd:cd01116 408 ATVYL 412
|
|
| YbiR_permease |
cd01117 |
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ... |
24-421 |
1.10e-18 |
|
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.
Pssm-ID: 238537 [Multi-domain] Cd Length: 384 Bit Score: 87.33 E-value: 1.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 24 LDIGFTALAGAIVAMITGVVSLTDVFEVtgIVWNATLTFVSVILISLILDKIGFFEWSAIHMLhASKGNGLKMFVYIILL 103
Cdd:cd01117 11 LDRWAIALLGAALMLLFGVISLEDAPAA--IDLDTIILLFGLMVVSAALELSGFFDALGSRIL-VKAGSPRRLLFLLVLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 104 GAVVAAFFANDGSALILTPIVLAMVKNIGFSkraIFPFIIASGFIADTTSLPLIVSNLVNIISADYFNISFSQYLSRMII 183
Cdd:cd01117 88 SGILSALLTNDTACLVFTPIVLELARVAGLP---PIPLLLALATAANIGSAATPIGNPQNLLIASESGISFPFFLAAMAP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 184 PNLFSLLGSLLVLWLYFRKAIPKSFDANHIKKPKDAINDLKLFKISWIVLVILLFGYLiseFTKIPVSIFTGIIAFIFLM 263
Cdd:cd01117 165 LALLGLLLLLILLLVLFPGELKGLPLDKATKEEGVGARKLAVKLLVLILLLLVAFLAL---LGVIPLWTAALVAAVLLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 264 LARKSnavniKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILAKILEYisnyglFSTILGMGFISAFLSSIMNNMPTV 343
Cdd:cd01117 242 TRLKP-----RRVLKKVDWGLLLFFAGLFILVGGFAQGLPLEGLSRLLPL------LDSVLSLFLVSIGLSQLISNVPAV 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 995435237 344 LIDAIAIGQSNVHGMLkegliyANVIGSDLGPKITPIGSLATLLWLHVLTQKDVKISWGTYFKTGITITIPVLFITLL 421
Cdd:cd01117 311 LLLLPFLPSADEKDWL------LLAAGSTIAGNLTLLGSAANLIVAEAAERRGVRLSFGEFLKYGVPLTLLTAAIGIL 382
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
63-345 |
5.40e-12 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 66.72 E-value: 5.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 63 VSVILISLILDKIGFFEWSAIHMLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFP-- 140
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGsa 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 141 FIIASGFIADTTSLPLIVSNLVNIISADYF------NISFSQYLSRMIIPNLFSLLGSLLVLWLYFRKAIPKSFDANHIK 214
Cdd:COG0471 81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLeeatgiPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPGSKEVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 215 KPKDAindlKLFKISW------IVLVILLFGYLISEFTKIPVSIFTGIIAFIFLMLarksNAVNIKQVIKGAPWNIVLFS 288
Cdd:COG0471 161 REELA----ELGPLSRrekialAIFALTVLLWITGSLHGIPIAVVALLGAVLLLLT----GVLTWKDAYKSIPWGVLLLF 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 995435237 289 IGMYIVVFGLRNAGITLILA-KILEYISNYGLFSTILGMGFISAFLSSIMNNMPTVLI 345
Cdd:COG0471 233 GGGLALGAALEKTGLAAWLAdALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAAL 290
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
17-425 |
1.93e-09 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 59.14 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 17 VLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFevTGIVWNATLTFVSVILISLILDKIGFFEWSAIHMLHASKGNGLKM 96
Cdd:cd01115 9 VLFVTEALPLDVTALLVPVLLVLLGVVPPKEAF--SGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 97 FVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIGFSKRAIFPFIIASGFIADTTSLpliVSNLVNIISADYFNISFSQ 176
Cdd:cd01115 87 LLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTL---IGTPPNLVASGYLESLGGQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 177 YLSRMIIPNLFSLLGSLLVLWLYFRKAIPKsfdanhikkpkdaindlklfkiswIVLVILLFGYLISEFTKIPVSIFTGI 256
Cdd:cd01115 164 GFSFFEFTPIGLPLLIIGLLYLWFIFRLAV------------------------LIITIVLLAALAAITGLLPVSVAIAI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 257 IAFIFLMlarkSNAVNIKQVIKGAPWNIVLFSIGMYIVVFGLRNAGITLILA-KILEYISNYGLFSTILGMGFISAFLSS 335
Cdd:cd01115 220 GAIVLVF----GGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAeALISLLGGLPPFAILLLLCLLTLVLTN 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 336 IMNNMPTVLIDA-IAIGQSNVHGMLKEGLIYANVIGSDLgPKITPIGSLATLLwlhVLTQKDVKISwgTYFKTGITITIP 414
Cdd:cd01115 296 FISNTATAVLLApIALSIALSLGLPPEALLLAVAIGASC-AFMLPVGTPPNAI---VLGPGGYKFS--DFAKVGLPLSIL 369
|
410
....*....|.
gi 995435237 415 VLFITLLGLYL 425
Cdd:cd01115 370 SLVVSVTMIPL 380
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
5-149 |
1.96e-06 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 49.77 E-value: 1.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 5 LATLIFLVTLLFVLWQP-KGLDIGFTALAGAIVAMITGVVSLTDVFEvtGIVWNATLTFVSVILISLILDKIGFFEWSAI 83
Cdd:COG0471 176 IALAIFALTVLLWITGSlHGIPIAVVALLGAVLLLLTGVLTWKDAYK--SIPWGVLLLFGGGLALGAALEKTGLAAWLAD 253
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 995435237 84 HMLHASKGNGLKMFVYIILLGAVVAAFFA-NDGSALILTPIVLAMVKNIGFSkraIFPFIIASGFIA 149
Cdd:COG0471 254 ALLPLLGGLSPLLLLLLLALLTLLLTEFAsNTATAALLLPIAISLAQALGVN---PLPLALAVAFAA 317
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
6-132 |
1.71e-04 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 43.78 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 6 ATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSltDVFEVTGIV-WNATLTFVSVILISLILDKIGFFEWSAIH 84
Cdd:cd01116 221 LTILTLVIIGFVLHSPLGVSLGWIALLGALLLLLLADKL--DFEDVLSRVeWDTLLFFAGLFVLVGGLEELGIIEWIAEL 298
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 995435237 85 MLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAMVKNIG 132
Cdd:cd01116 299 LVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLG 346
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
1-127 |
4.19e-03 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 39.34 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435237 1 MMTTLATLIFLVTLLFVLWQPKGLDIGFTALAGAIVAMITGVVSLTDVFEvtGIVWNATLTFVSVILISLILDKIGFFEW 80
Cdd:COG1055 217 LLRISLLVLALLLVGFVLHSFLGLPPALIALLGAAVLLLLARVDVREVLK--KVDWSTLLFFIGLFVVVGGLENTGLLDL 294
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 995435237 81 SAIHMLHASKGNGLKMFVYIILLGAVVAAFFANDGSALILTPIVLAM 127
Cdd:COG1055 295 LAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDL 341
|
|
| |
