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Conserved domains on  [gi|995435227|emb|CYD26605|]
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Staphylococcal accessory regulator [Staphylococcus aureus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 14-116 3.54e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member TIGR01889:

Pssm-ID: 481197  Cd Length: 109  Bit Score: 71.52  E-value: 3.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435227   14 QLETLLGDINSIFSEIESEYKMSREEILIL----LTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDD 89
Cdd:TIGR01889   2 DLLSLYLYIKSLKRYLKKEFNLSLEELLILyylgKLENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSEDD 81

                          90       100
                  ....*....|....*....|....*...
gi 995435227   90 ERTVIIHFNEKlQQEKVE-LLNFISDAI 116
Cdd:TIGR01889  82 ERKVIISINKE-QRSKIEsLISEIEQII 108
 
Name Accession Description Interval E-value
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 14-116 3.54e-17

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 71.52  E-value: 3.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435227   14 QLETLLGDINSIFSEIESEYKMSREEILIL----LTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDD 89
Cdd:TIGR01889   2 DLLSLYLYIKSLKRYLKKEFNLSLEELLILyylgKLENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSEDD 81

                          90       100
                  ....*....|....*....|....*...
gi 995435227   90 ERTVIIHFNEKlQQEKVE-LLNFISDAI 116
Cdd:TIGR01889  82 ERKVIISINKE-QRSKIEsLISEIEQII 108
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-100 5.26e-08

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 47.59  E-value: 5.26e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 995435227    28 EIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEK 100
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEE 73
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 35-93 6.35e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.99  E-value: 6.35e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 995435227   35 MSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTV 93
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-100 9.15e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.87  E-value: 9.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435227   1 MKKVNNDTVFGI-LQLETLLGDINSIFSEIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELE 79
Cdd:COG1846    1 MSDEPDPAEERLgLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100
                 ....*....|....*....|.
gi 995435227  80 WIYKERPVDDERTVIIHFNEK 100
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEK 101
 
Name Accession Description Interval E-value
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 14-116 3.54e-17

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 71.52  E-value: 3.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435227   14 QLETLLGDINSIFSEIESEYKMSREEILIL----LTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDD 89
Cdd:TIGR01889   2 DLLSLYLYIKSLKRYLKKEFNLSLEELLILyylgKLENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSEDD 81

                          90       100
                  ....*....|....*....|....*...
gi 995435227   90 ERTVIIHFNEKlQQEKVE-LLNFISDAI 116
Cdd:TIGR01889  82 ERKVIISINKE-QRSKIEsLISEIEQII 108
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-100 5.26e-08

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 47.59  E-value: 5.26e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 995435227    28 EIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTVIIHFNEK 100
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEE 73
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 35-93 6.35e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 40.99  E-value: 6.35e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 995435227   35 MSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELEWIYKERPVDDERTV 93
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-100 9.15e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.87  E-value: 9.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995435227   1 MKKVNNDTVFGI-LQLETLLGDINSIFSEIESEYKMSREEILILLTLWQKGSMTLKEMDRFVEVKPYKRTRTYNNLVELE 79
Cdd:COG1846    1 MSDEPDPAEERLgLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                         90       100
                 ....*....|....*....|.
gi 995435227  80 WIYKERPVDDERTVIIHFNEK 100
Cdd:COG1846   81 LVEREPDPEDRRAVLVRLTEK 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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