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Conserved domains on  [gi|995475898|emb|CYA85382|]
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Thioredoxin-disulfide reductase [Staphylococcus aureus]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11422994)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

CATH:  3.50.50.60
EC:  1.-.-.-
Gene Ontology:  GO:0050660|GO:0016491
PubMed:  33684359

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-316 2.66e-68

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 216.14  E-value: 2.66e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   3 DVTIIGGGPSGLYASFYAGLRDMSVRLIDvQSELGGKMRIYPEkiIWDIGGIAPK-PCHEILKDTIKQGLYFKPEVHLnE 81
Cdd:COG0492    2 DVVIIGAGPAGLTAAIYAARAGLKTLVIE-GGEPGGQLATTKE--IENYPGFPEGiSGPELAERLREQAERFGAEILL-E 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  82 RVVDIRKkAERHFEVETEAGEIYTSKAV-----IiaigagiiNPKQLDVKGVERYQLTNLHY--VVQSYRrFKDKDVLIS 154
Cdd:COG0492   78 EVTSVDK-DDGPFRVTTDDGTEYEAKAViiatgA--------GPRKLGLPGEEEFEGRGVSYcaTCDGFF-FRGKDVVVV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 155 GGGNTALDWAHDIAKIAKSVTVVYRKEDVSGHEAMKTLVTDL-NVKLCPKTRIKYLVGNDdetHISEVVLEHVESGDTHT 233
Cdd:COG0492  148 GGGDSALEEALYLTKFASKVTLIHRRDELRASKILVERLRANpKIEVLWNTEVTEIEGDG---RVEGVTLKNVKTGEEKE 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 234 VKFDDVIISHGFDRCNTLLSETSskLDMHDDCRVKGFGNTTTSIPGIYACGDIVYHdaKSHLIASAFSDGANAANLAKTY 313
Cdd:COG0492  225 LEVDGVFVAIGLKPNTELLKGLG--LELDEDGYIVVDEDMETSVPGVFAAGDVRDY--KYRQAATAAGEGAIAALSAARY 300


                 ...
gi 995475898 314 IQP 316
Cdd:COG0492  301 LEP 303
 
Name Accession Description Interval E-value
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-316 2.66e-68

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 216.14  E-value: 2.66e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   3 DVTIIGGGPSGLYASFYAGLRDMSVRLIDvQSELGGKMRIYPEkiIWDIGGIAPK-PCHEILKDTIKQGLYFKPEVHLnE 81
Cdd:COG0492    2 DVVIIGAGPAGLTAAIYAARAGLKTLVIE-GGEPGGQLATTKE--IENYPGFPEGiSGPELAERLREQAERFGAEILL-E 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  82 RVVDIRKkAERHFEVETEAGEIYTSKAV-----IiaigagiiNPKQLDVKGVERYQLTNLHY--VVQSYRrFKDKDVLIS 154
Cdd:COG0492   78 EVTSVDK-DDGPFRVTTDDGTEYEAKAViiatgA--------GPRKLGLPGEEEFEGRGVSYcaTCDGFF-FRGKDVVVV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 155 GGGNTALDWAHDIAKIAKSVTVVYRKEDVSGHEAMKTLVTDL-NVKLCPKTRIKYLVGNDdetHISEVVLEHVESGDTHT 233
Cdd:COG0492  148 GGGDSALEEALYLTKFASKVTLIHRRDELRASKILVERLRANpKIEVLWNTEVTEIEGDG---RVEGVTLKNVKTGEEKE 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 234 VKFDDVIISHGFDRCNTLLSETSskLDMHDDCRVKGFGNTTTSIPGIYACGDIVYHdaKSHLIASAFSDGANAANLAKTY 313
Cdd:COG0492  225 LEVDGVFVAIGLKPNTELLKGLG--LELDEDGYIVVDEDMETSVPGVFAAGDVRDY--KYRQAATAAGEGAIAALSAARY 300


                 ...
gi 995475898 314 IQP 316
Cdd:COG0492  301 LEP 303
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 2-286 1.89e-18

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 84.29  E-value: 1.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898    2 KDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSE-LGGKMRIYpeKIIWDIGGIApkpchEILKDTIKqgLYFKPEVHLN 80
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGTcPYGGCVLS--KALLGAAEAP-----EIASLWAD--LYKRKEEVVK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   81 ERVVDIRKKAERH-FEVETEAGEIYTSKAVIIAIGAGIIN---------PKQLDVKGVERYQLTNLHYvVQSYRRFKDKD 150
Cdd:pfam07992  72 KLNNGIEVLLGTEvVSIDPGAKKVVLEELVDGDGETITYDrlviatgarPRLPPIPGVELNVGFLVRT-LDSAEALRLKL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  151 ----VLISGGGNTALDWAHDIAKIAKSVTVVYRKEDVSGH------EAMKTLVTDLNVKLCPKTRIKYLVGNDDethISE 220
Cdd:pfam07992 151 lpkrVVVVGGGYIGVELAAALAKLGKEVTLIEALDRLLRAfdeeisAALEKALEKNGVEVRLGTSVKEIIGDGD---GVE 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 995475898  221 VVLehvesGDTHTVKFDDVIISHGFdRCNTLLSETSS-KLDMHDDCRVKGFGNttTSIPGIYACGDI 286
Cdd:pfam07992 228 VIL-----KDGTEIDADLVVVAIGR-RPNTELLEAAGlELDERGGIVVDEYLR--TSVPGIYAAGDC 286
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 2-307 3.09e-13

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 70.21  E-value: 3.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   2 KDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRiYpekiiwdigGIA----PKpchEILK---DTIKQ-GLYF 73
Cdd:PRK11749 141 KKVAVIGAGPAGLTAAHRLARKGYDVTIFEARDKAGGLLR-Y---------GIPefrlPK---DIVDrevERLLKlGVEI 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  74 KPEVHLnERVVDIRKKAERH---FeVETEAGeiytskaviiaigagiiNPKQLDVKGVER--------YqLTNLHYVVQS 142
Cdd:PRK11749 208 RTNTEV-GRDITLDELRAGYdavF-IGTGAG-----------------LPRFLGIPGENLggvysavdF-LTRVNQAVAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 143 YRRFKDKDVLISGGGNTALDWAHdIAKI--AKSVTVVYR--KEDVSG-----HEAMKTLVTdLNVKLCPKtRIKylvgnD 213
Cdd:PRK11749 268 YDLPVGKRVVVIGGGNTAMDAAR-TAKRlgAESVTIVYRrgREEMPAseeevEHAKEEGVE-FEWLAAPV-EIL-----G 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 214 DETHISEVVLEHVESGD--------------THTVKFDDVIISHGFDRcNTLLSETSSKLDM-HDDCRVKGFGNTTTSIP 278
Cdd:PRK11749 340 DEGRVTGVEFVRMELGEpdasgrrrvpiegsEFTLPADLVIKAIGQTP-NPLILSTTPGLELnRWGTIIADDETGRTSLP 418

                        330       340
                 ....*....|....*....|....*....
gi 995475898 279 GIYACGDIVYHDAkshLIASAFSDGANAA 307
Cdd:PRK11749 419 GVFAGGDIVTGAA---TVVWAVGDGKDAA 444
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 6-109 4.63e-06

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 47.98  E-value: 4.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898    6 IIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIY------------PEKIIWDIGGiAPKPCHEIL-----KDTI- 67
Cdd:TIGR00275   2 IIGGGAAGLMAAITAARAGLSVLLLEKNKKIGKKLLISgggrcnltnscpTPEFVAYYPR-NGKFLRSALsrfsnKDLId 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 995475898   68 ---KQGLYFK--------P---------------------EVHLNERVVDIRKKAERhFEVETEaGEIYTSKAV 109
Cdd:TIGR00275  81 ffeSLGLELKveedgrvfPcsdsaadvldallnelkelgvEILTNSKVKSIEKEDGG-FGVETS-GGEYEADKV 152
 
Name Accession Description Interval E-value
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
3-316 2.66e-68

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 216.14  E-value: 2.66e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   3 DVTIIGGGPSGLYASFYAGLRDMSVRLIDvQSELGGKMRIYPEkiIWDIGGIAPK-PCHEILKDTIKQGLYFKPEVHLnE 81
Cdd:COG0492    2 DVVIIGAGPAGLTAAIYAARAGLKTLVIE-GGEPGGQLATTKE--IENYPGFPEGiSGPELAERLREQAERFGAEILL-E 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  82 RVVDIRKkAERHFEVETEAGEIYTSKAV-----IiaigagiiNPKQLDVKGVERYQLTNLHY--VVQSYRrFKDKDVLIS 154
Cdd:COG0492   78 EVTSVDK-DDGPFRVTTDDGTEYEAKAViiatgA--------GPRKLGLPGEEEFEGRGVSYcaTCDGFF-FRGKDVVVV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 155 GGGNTALDWAHDIAKIAKSVTVVYRKEDVSGHEAMKTLVTDL-NVKLCPKTRIKYLVGNDdetHISEVVLEHVESGDTHT 233
Cdd:COG0492  148 GGGDSALEEALYLTKFASKVTLIHRRDELRASKILVERLRANpKIEVLWNTEVTEIEGDG---RVEGVTLKNVKTGEEKE 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 234 VKFDDVIISHGFDRCNTLLSETSskLDMHDDCRVKGFGNTTTSIPGIYACGDIVYHdaKSHLIASAFSDGANAANLAKTY 313
Cdd:COG0492  225 LEVDGVFVAIGLKPNTELLKGLG--LELDEDGYIVVDEDMETSVPGVFAAGDVRDY--KYRQAATAAGEGAIAALSAARY 300


                 ...
gi 995475898 314 IQP 316
Cdd:COG0492  301 LEP 303
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 2-286 1.89e-18

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 84.29  E-value: 1.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898    2 KDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSE-LGGKMRIYpeKIIWDIGGIApkpchEILKDTIKqgLYFKPEVHLN 80
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIEDEGTcPYGGCVLS--KALLGAAEAP-----EIASLWAD--LYKRKEEVVK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   81 ERVVDIRKKAERH-FEVETEAGEIYTSKAVIIAIGAGIIN---------PKQLDVKGVERYQLTNLHYvVQSYRRFKDKD 150
Cdd:pfam07992  72 KLNNGIEVLLGTEvVSIDPGAKKVVLEELVDGDGETITYDrlviatgarPRLPPIPGVELNVGFLVRT-LDSAEALRLKL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  151 ----VLISGGGNTALDWAHDIAKIAKSVTVVYRKEDVSGH------EAMKTLVTDLNVKLCPKTRIKYLVGNDDethISE 220
Cdd:pfam07992 151 lpkrVVVVGGGYIGVELAAALAKLGKEVTLIEALDRLLRAfdeeisAALEKALEKNGVEVRLGTSVKEIIGDGD---GVE 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 995475898  221 VVLehvesGDTHTVKFDDVIISHGFdRCNTLLSETSS-KLDMHDDCRVKGFGNttTSIPGIYACGDI 286
Cdd:pfam07992 228 VIL-----KDGTEIDADLVVVAIGR-RPNTELLEAAGlELDERGGIVVDEYLR--TSVPGIYAAGDC 286
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-179 8.43e-16

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 77.60  E-value: 8.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   1 MKDVTIIGGGPSGLYASFYagLRDM--SVRLIDVQSELGG--------------KMRIY--PEKIIW-DIGGIAPKPchE 61
Cdd:COG2072    6 HVDVVVIGAGQAGLAAAYH--LRRAgiDFVVLEKADDVGGtwrdnrypglrldtPSHLYslPFFPNWsDDPDFPTGD--E 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  62 I---LKDTIKQ-GLYfkPEVHLNERVVDIR-KKAERHFEVETEAGEIYTSKAViiaigagiiNPKQLDVKGVERYQLTNL 136
Cdd:COG2072   82 IlayLEAYADKfGLR--RPIRFGTEVTSARwDEADGRWTVTTDDGETLTARFVvvat-gplsRPKIPDIPGLEDFAGEQL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 995475898 137 HyvVQSYRR---FKDKDVLISGGGNTALDWAHDIAKIAKSVTVVYR 179
Cdd:COG2072  159 H--SADWRNpvdLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQR 202
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 2-307 5.05e-14

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 72.47  E-value: 5.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   2 KDVTIIGGGPSGLYASFYagLRDM--SVRLIDVQSELGGKMRiYpekiiwdigGIA----PKpchEILKDTIKQ----GL 71
Cdd:COG0493  122 KKVAVVGSGPAGLAAAYQ--LARAghEVTVFEALDKPGGLLR-Y---------GIPefrlPK---DVLDREIELiealGV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  72 yfkpEVHLNERV-VDIR-KKAERHFE---VETEAGEiytskaviiaigagiinPKQLDVKGVEryqLTNLH----YVVQS 142
Cdd:COG0493  187 ----EFRTNVEVgKDITlDELLEEFDavfLATGAGK-----------------PRDLGIPGED---LKGVHsamdFLTAV 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 143 YRR-------FKDKDVLISGGGNTALdwahDIAKI-----AKSVTVVYRKedvsGHEAMKTLVTDL------NVKLCPKT 204
Cdd:COG0493  243 NLGeapdtilAVGKRVVVIGGGNTAM----DCARTalrlgAESVTIVYRR----TREEMPASKEEVeealeeGVEFLFLV 314

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 205 RIKYLVGNDDEtHISEVVLEHVE---------------SGDTHTVKFDDVIISHGFDRcNTLLSETSSKLDMHDDCRVKG 269
Cdd:COG0493  315 APVEIIGDENG-RVTGLECVRMElgepdesgrrrpvpiEGSEFTLPADLVILAIGQTP-DPSGLEEELGLELDKRGTIVV 392

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 995475898 270 FGNT-TTSIPGIYACGDIVYhdaKSHLIASAFSDGANAA 307
Cdd:COG0493  393 DEETyQTSLPGVFAGGDAVR---GPSLVVWAIAEGRKAA 428
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 2-307 3.09e-13

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 70.21  E-value: 3.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   2 KDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRiYpekiiwdigGIA----PKpchEILK---DTIKQ-GLYF 73
Cdd:PRK11749 141 KKVAVIGAGPAGLTAAHRLARKGYDVTIFEARDKAGGLLR-Y---------GIPefrlPK---DIVDrevERLLKlGVEI 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  74 KPEVHLnERVVDIRKKAERH---FeVETEAGeiytskaviiaigagiiNPKQLDVKGVER--------YqLTNLHYVVQS 142
Cdd:PRK11749 208 RTNTEV-GRDITLDELRAGYdavF-IGTGAG-----------------LPRFLGIPGENLggvysavdF-LTRVNQAVAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 143 YRRFKDKDVLISGGGNTALDWAHdIAKI--AKSVTVVYR--KEDVSG-----HEAMKTLVTdLNVKLCPKtRIKylvgnD 213
Cdd:PRK11749 268 YDLPVGKRVVVIGGGNTAMDAAR-TAKRlgAESVTIVYRrgREEMPAseeevEHAKEEGVE-FEWLAAPV-EIL-----G 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 214 DETHISEVVLEHVESGD--------------THTVKFDDVIISHGFDRcNTLLSETSSKLDM-HDDCRVKGFGNTTTSIP 278
Cdd:PRK11749 340 DEGRVTGVEFVRMELGEpdasgrrrvpiegsEFTLPADLVIKAIGQTP-NPLILSTTPGLELnRWGTIIADDETGRTSLP 418

                        330       340
                 ....*....|....*....|....*....
gi 995475898 279 GIYACGDIVYHDAkshLIASAFSDGANAA 307
Cdd:PRK11749 419 GVFAGGDIVTGAA---TVVWAVGDGKDAA 444
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
72-246 6.26e-11

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 62.24  E-value: 6.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   72 YFKPEVHLNERVVDIrKKAERHFEVETEAGEiYTSKAVIIAIGAGIiNPKQLDVKgveryQLTNLHYVVQSYRRFKDKDV 151
Cdd:pfam13738  87 HFELPINLFEEVTSV-KKEDDGFVVTTSKGT-YQARYVIIATGEFD-FPNKLGVP-----ELPKHYSYVKDFHPYAGQKV 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  152 LISGGGNTALDWAHDIAKIAKSVTVVYRKE-------DVSGH------EAMKTLVTDLNVKLCPKTRIKylvgndDETHI 218
Cdd:pfam13738 159 VVIGGYNSAVDAALELVRKGARVTVLYRGSewedrdsDPSYSlspdtlNRLEELVKNGKIKAHFNAEVK------EITEV 232

                         170       180
                  ....*....|....*....|....*...
gi 995475898  219 SEVVLEHVESGDTHTVKfDDVIISHGFD 246
Cdd:pfam13738 233 DVSYKVHTEDGRKVTSN-DDPILATGYH 259
PRK12831 PRK12831
putative oxidoreductase; Provisional
 149-316 1.07e-08

putative oxidoreductase; Provisional


Pssm-ID: 183780 [Multi-domain]  Cd Length: 464  Bit Score: 56.18  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 149 KDVLISGGGNTALDWAHDIAKIAKSVTVVYR---------KEDVsgHEAM------------KTLVTDLNVKLCPKTRIK 207
Cdd:PRK12831 282 KKVAVVGGGNVAMDAARTALRLGAEVHIVYRrseeelparVEEV--HHAKeegvifdlltnpVEILGDENGWVKGMKCIK 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 208 YLVGNDDET-HISEVVLEhvesGDTHTVKFDDVIISHGfDRCNTLLSETSSKLDMHDDCRVKGFGNT-TTSIPGIYACGD 285
Cdd:PRK12831 360 MELGEPDASgRRRPVEIE----GSEFVLEVDTVIMSLG-TSPNPLISSTTKGLKINKRGCIVADEETgLTSKEGVFAGGD 434

                        170       180       190
                 ....*....|....*....|....*....|.
gi 995475898 286 IVYHDAKSHLiasAFSDGANAANLAKTYIQP 316
Cdd:PRK12831 435 AVTGAATVIL---AMGAGKKAAKAIDEYLSK 462
PRK12778 PRK12778
bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate ...
 149-315 4.80e-08

bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate synthase;


Pssm-ID: 237200 [Multi-domain]  Cd Length: 752  Bit Score: 54.75  E-value: 4.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 149 KDVLISGGGNTALDWAHDIAKI-AKSVTVVYRKedvsGHEAMKTLVTDlnVKLCPKTRIKYL-------VGNDDETHISE 220
Cdd:PRK12778 571 KKVAVVGGGNTAMDSARTAKRLgAERVTIVYRR----SEEEMPARLEE--VKHAKEEGIEFLtlhnpieYLADEKGWVKQ 644

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 221 VVLEHVE---------------SGDTHTVKFDDVIISHGFDRcNTLLSETSSKLDMHDDCRVKGFGNTTTSIPGIYACGD 285
Cdd:PRK12778 645 VVLQKMElgepdasgrrrpvaiPGSTFTVDVDLVIVSVGVSP-NPLVPSSIPGLELNRKGTIVVDEEMQSSIPGIYAGGD 723

                        170       180       190
                 ....*....|....*....|....*....|
gi 995475898 286 IVYHDAKSHLiasAFSDGANAANLAKTYIQ 315
Cdd:PRK12778 724 IVRGGATVIL---AMGDGKRAAAAIDEYLS 750
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 1-53 1.59e-07

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 52.53  E-value: 1.59e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 995475898   1 MKDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIYPEK-IIWDIGG 53
Cdd:COG1232    1 MKRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGLIRTVEVDgFRIDRGP 54
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 2-287 1.80e-07

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 52.57  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   2 KDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRiYpekiiwdigGIA----PKpchEILKDTIKQGLYFKPEV 77
Cdd:PRK12771 138 KRVAVIGGGPAGLSAAYHLRRMGHAVTIFEAGPKLGGMMR-Y---------GIPayrlPR---EVLDAEIQRILDLGVEV 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  78 HLNERV-VDI-RKKAERHFE-----VETEAGeiytskaviiaigagiinpKQLDVKGVERYQLTN----LHYVVQSYRRF 146
Cdd:PRK12771 205 RLGVRVgEDItLEQLEGEFDavfvaIGAQLG-------------------KRLPIPGEDAAGVLDavdfLRAVGEGEPPF 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 147 KDKDVLISGGGNTALDWAHdIAKI--AKSVTVVYR--KEDVSGHEA-----------MKTLVTDLNVklcpktrikyLVG 211
Cdd:PRK12771 266 LGKRVVVIGGGNTAMDAAR-TARRlgAEEVTIVYRrtREDMPAHDEeieealregveINWLRTPVEI----------EGD 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 212 NDDETHISEVVLE----------HVESGDTHTVKFDDVIISHGFDrCNTLLSETSSKLDMHDDCRVKGFGNTTTSIPGIY 281
Cdd:PRK12771 335 ENGATGLRVITVEkmeldedgrpSPVTGEEETLEADLVVLAIGQD-IDSAGLESVPGVEVGRGVVQVDPNFMMTGRPGVF 413


                 ....*.
gi 995475898 282 ACGDIV 287
Cdd:PRK12771 414 AGGDMV 419
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
76-310 2.00e-07

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 52.07  E-value: 2.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  76 EVHLNERVVDIRkkAERHfEVETEAGEIYT---------SKaviiaigagiinPKQLDVKGVEryqLTNLHYV--VQSYR 144
Cdd:COG1251   72 DLRLGTRVTAID--RAAR-TVTLADGETLPydklvlatgSR------------PRVPPIPGAD---LPGVFTLrtLDDAD 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 145 RFKD-----KDVLISGGGNTALDWAHDIAKIAKSVTVVYRKE-------DVSGHEAMKTLVTDLNVKLCPKTRIKYLVGN 212
Cdd:COG1251  134 ALRAalapgKRVVVIGGGLIGLEAAAALRKRGLEVTVVERAPrllprqlDEEAGALLQRLLEALGVEVRLGTGVTEIEGD 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 213 DdetHISEVVLEhvesgDTHTVKFDDVIISHGFdRCNT-LLSEtsSKLDMH------DDCRvkgfgnttTSIPGIYACGD 285
Cdd:COG1251  214 D---RVTGVRLA-----DGEELPADLVVVAIGV-RPNTeLARA--AGLAVDrgivvdDYLR--------TSDPDIYAAGD 274

                        250       260       270
                 ....*....|....*....|....*....|..
gi 995475898 286 IVYHD------AKSHLIASAFSDGANAA-NLA 310
Cdd:COG1251  275 CAEHPgpvygrRVLELVAPAYEQARVAAaNLA 306
PRK12779 PRK12779
putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; ...
 147-285 6.02e-07

putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Provisional


Pssm-ID: 183740 [Multi-domain]  Cd Length: 944  Bit Score: 51.37  E-value: 6.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 147 KDKDVLISGGGNTALDWAHDIAKIAKSVTVVYRKEdvsgHEAMKTLVTDLNVKLCPKTRIKYLVG-----NDDETH-ISE 220
Cdd:PRK12779 446 KGKEVFVIGGGNTAMDAARTAKRLGGNVTIVYRRT----KSEMPARVEELHHALEEGINLAVLRAprefiGDDHTHfVTH 521

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 221 VVLEHVE--------------SGDTHTVKFDDVIISHGfDRCNTLLSETSSKLDMHDDCRVK-GFGNTTTSIPGIYACGD 285
Cdd:PRK12779 522 ALLDVNElgepdksgrrspkpTGEIERVPVDLVIMALG-NTANPIMKDAEPGLKTNKWGTIEvEKGSQRTSIKGVYSGGD 600
PRK15317 PRK15317
alkyl hydroperoxide reductase subunit F; Provisional
 3-307 1.13e-06

alkyl hydroperoxide reductase subunit F; Provisional


Pssm-ID: 237942 [Multi-domain]  Cd Length: 517  Bit Score: 50.16  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   3 DVTIIGGGPSGLYASFYA---GLRdmsVRLidVQSELGGK----MRIypEKIIwdigGIA----PKPCHEiLKDTIKQgl 71
Cdd:PRK15317 213 DVLVVGGGPAGAAAAIYAarkGIR---TGI--VAERFGGQvldtMGI--ENFI----SVPetegPKLAAA-LEEHVKE-- 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  72 YfkpEVHL--NERVVDIRKKAERHfEVETEAGEIYTSKAVIIAIGAgiiNPKQLDVKGVERYqltnlhyvvqsyrR---- 145
Cdd:PRK15317 279 Y---DVDImnLQRASKLEPAAGLI-EVELANGAVLKAKTVILATGA---RWRNMNVPGEDEY-------------Rnkgv 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 146 ----------FKDKDVLISGGGNTALDWAHDIAKIAKSVTVVyrkEDVSGHEAMKTLVTDL----NVKLCPKTRIKYLVG 211
Cdd:PRK15317 339 aycphcdgplFKGKRVAVIGGGNSGVEAAIDLAGIVKHVTVL---EFAPELKADQVLQDKLrslpNVTIITNAQTTEVTG 415

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 212 NDDetHISEVVLEHVESGDTHTVKFDDVIISHGfdrcntLLSET-----SSKLDMHDDCRVKGFGNttTSIPGIYACGD- 285
Cdd:PRK15317 416 DGD--KVTGLTYKDRTTGEEHHLELEGVFVQIG------LVPNTewlkgTVELNRRGEIIVDARGA--TSVPGVFAAGDc 485

                        330       340
                 ....*....|....*....|....
gi 995475898 286 --IVYhdaKSHLIasAFSDGANAA 307
Cdd:PRK15317 486 ttVPY---KQIII--AMGEGAKAA 504
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 76-310 1.55e-06

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 49.04  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  76 EVHLNERVVDIRKKAERhfeVETEAGEIYT---------SKaviiaigagiinPKQLDVKGVER---YQLTNLH---YVV 140
Cdd:COG0446   52 DVRTGTEVTAIDPEAKT---VTLRDGETLSydklvlatgAR------------PRPPPIPGLDLpgvFTLRTLDdadALR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 141 QSYRRFKDKDVLISGGGNTALDWAHDIAKIAKSVTVVYRK--------EDVSghEAMKTLVTDLNVKLCPKTRIKYLVGN 212
Cdd:COG0446  117 EALKEFKGKRAVVIGGGPIGLELAEALRKRGLKVTLVERAprllgvldPEMA--ALLEEELREHGVELRLGETVVAIDGD 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 213 DDEThisevvlehVESGDTHTVKFDDVIISHGFdRCNTLLSEtSSKLDMHDDC--RVKGFGNTttSIPGIYACGDIV--- 287
Cdd:COG0446  195 DKVA---------VTLTDGEEIPADLVVVAPGV-RPNTELAK-DAGLALGERGwiKVDETLQT--SDPDVYAAGDCAevp 261

                        250       260       270
                 ....*....|....*....|....*....|
gi 995475898 288 -YHDAKSHLIASAfsDGAN------AANLA 310
Cdd:COG0446  262 hPVTGKTVYIPLA--SAANkqgrvaAENIL 289
TIGR00275 TIGR00275
flavoprotein, HI0933 family; The model when searched with a partial length search brings in ...
 6-109 4.63e-06

flavoprotein, HI0933 family; The model when searched with a partial length search brings in proteins with a dinucleotide-binding motif (Rossman fold) over the initial 40 residues of the model, including oxidoreductases and dehydrogenases. Partially characterized members include an FAD-binding protein from Bacillus cereus and flavoprotein HI0933 from Haemophilus influenzae. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272992 [Multi-domain]  Cd Length: 400  Bit Score: 47.98  E-value: 4.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898    6 IIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIY------------PEKIIWDIGGiAPKPCHEIL-----KDTI- 67
Cdd:TIGR00275   2 IIGGGAAGLMAAITAARAGLSVLLLEKNKKIGKKLLISgggrcnltnscpTPEFVAYYPR-NGKFLRSALsrfsnKDLId 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 995475898   68 ---KQGLYFK--------P---------------------EVHLNERVVDIRKKAERhFEVETEaGEIYTSKAV 109
Cdd:TIGR00275  81 ffeSLGLELKveedgrvfPcsdsaadvldallnelkelgvEILTNSKVKSIEKEDGG-FGVETS-GGEYEADKV 152
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 151-214 8.19e-06

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 43.35  E-value: 8.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  151 VLISGGGNTALDWAHDIAKIAKSVTVVYR------KEDVSGHEAMKTLVTDLNVKLCPKTRIKYLVGNDD 214
Cdd:pfam00070   2 VVVVGGGYIGLELAGALARLGSKVTVVERrdrllpGFDPEIAKILQEKLEKNGIEFLLNTTVEAIEGNGD 71
HI0933_like pfam03486
HI0933-like protein;
2-109 1.02e-05

HI0933-like protein;


Pssm-ID: 427330 [Multi-domain]  Cd Length: 406  Bit Score: 46.81  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898    2 KDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIY-------------PEKIIWDIGGiAPKPCHEIL----- 63
Cdd:pfam03486   1 FDVIVIGGGAAGLMAAISAAKRGRRVLLIEKGKKLGRKILISgggrcnvtnlseePDNFLSRYPG-NPKFLKSALsrftp 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 995475898   64 KDTI----KQGLYFKPE-----------------------------VHLNERVVDIRKKAERHFEVETEAGEIYTSKAV 109
Cdd:pfam03486  80 WDFIaffeSLGVPLKEEdhgrlfpdsdkasdivdallnelkelgvkIRLRTRVLSVEKDDDGRFRVKTGGEELEADSLV 158
PRK10262 PRK10262
thioredoxin reductase; Provisional
 6-320 3.13e-05

thioredoxin reductase; Provisional


Pssm-ID: 182343 [Multi-domain]  Cd Length: 321  Bit Score: 45.05  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   6 IIGGGPSGLYASFYAGLRDMSVRLIdVQSELGGKMRIYPEKIIWD------IGGIAPKPCHEilkdtikQGLYFKPEV-- 77
Cdd:PRK10262  11 ILGSGPAGYTAAVYAARANLQPVLI-TGMEKGGQLTTTTEVENWPgdpndlTGPLLMERMHE-------HATKFETEIif 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  78 -HLNErvVDIRKkaeRHFEVETEAGEiYTSKAVIIAIGAgiiNPKQLDVKGVERYQLTNLHYVVQSYRRF-KDKDVLISG 155
Cdd:PRK10262  83 dHINK--VDLQN---RPFRLTGDSGE-YTCDALIIATGA---SARYLGLPSEEAFKGRGVSACATCDGFFyRNQKVAVIG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 156 GGNTALDWAHDIAKIAKSVTVVYRKEdvsGHEAMKTLVTDL-------NVKLCPKTRIKYLVGndDETHISEVVLEHVES 228
Cdd:PRK10262 154 GGNTAVEEALYLSNIASEVHLIHRRD---GFRAEKILIKRLmdkvengNIILHTNRTLEEVTG--DQMGVTGVRLRDTQN 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 229 GDT-HTVKFDDVIISHGFDRcNTLLSETSSKLDmHDDCRVKG--FGNTT-TSIPGIYACGDIVYHDAKSHLIASAfsDGA 304
Cdd:PRK10262 229 SDNiESLDVAGLFVAIGHSP-NTAIFEGQLELE-NGYIKVQSgiHGNATqTSIPGVFAAGDVMDHIYRQAITSAG--TGC 304

                        330
                 ....*....|....*.
gi 995475898 305 NAANLAKTYIQPDANA 320
Cdd:PRK10262 305 MAALDAERYLDGLADA 320
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 2-315 3.75e-05

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 44.98  E-value: 3.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   2 KDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMriypekiiwdIGGIapkPCHEILKDTIKQGL---------- 71
Cdd:PRK12770  19 KKVAIIGAGPAGLAAAGYLACLGYEVHVYDKLPEPGGLM----------LFGI---PEFRIPIERVREGVkeleeagvvf 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  72 YFKPEV------------HLNERVVDIRKKAERHfevetEAGEIYTSkaviiaigagIINPKQL-----DVKGVE----- 129
Cdd:PRK12770  86 HTRTKVccgeplheeegdEFVERIVSLEELVKKY-----DAVLIATG----------TWKSRKLgipgeDLPGVYsaley 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 130 --RYQLTNLHYVVQ-SYRRFKDKDVLISGGGNTALDWAHDIAKI-AKSVTVVYR---KEDVSGHEAMKTLVtDLNVK--- 199
Cdd:PRK12770 151 lfRIRAAKLGYLPWeKVPPVEGKKVVVVGAGLTAVDAALEAVLLgAEKVYLAYRrtiNEAPAGKYEIERLI-ARGVEfle 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 200 LCPKTRI------------KYLVGNDDETHISEVVlehVESGDTHTVKFDDVIISHGfDRCNTLLSETSSKLDMHDDCRV 267
Cdd:PRK12770 230 LVTPVRIigegrvegvelaKMRLGEPDESGRPRPV---PIPGSEFVLEADTVVFAIG-EIPTPPFAKECLGIELNRKGEI 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 995475898 268 KGFGNTTTSIPGIYACGDIVYHDAKshlIASAFSDGANAANLAKTYIQ 315
Cdd:PRK12770 306 VVDEKHMTSREGVFAAGDVVTGPSK---IGKAIKSGLRAAQSIHEWLD 350
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
6-46 5.35e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 40.59  E-value: 5.35e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 995475898    6 IIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIYPEK 46
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRVP 41
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 2-180 9.96e-05

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 43.95  E-value: 9.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   2 KDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRiY-------PEKIIwdIGGIAPKpchEILKDTIKQGLYFK 74
Cdd:PRK12814 194 KKVAIIGAGPAGLTAAYYLLRKGHDVTIFDANEQAGGMMR-YgiprfrlPESVI--DADIAPL---RAMGAEFRFNTVFG 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  75 PEVHLNErvvdIRKKaerhFEVETEAgeIYTSKAviiaigagiinpKQLDVKGVERYQLTN----LHYVVQSYRRFKDKD 150
Cdd:PRK12814 268 RDITLEE----LQKE----FDAVLLA--VGAQKA------------SKMGIPGEELPGVISgidfLRNVALGTALHPGKK 325

                        170       180       190
                 ....*....|....*....|....*....|.
gi 995475898 151 VLISGGGNTALDWAHDIAKI-AKSVTVVYRK 180
Cdd:PRK12814 326 VVVIGGGNTAIDAARTALRLgAESVTILYRR 356
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 3-318 1.58e-04

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 43.24  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   3 DVTIIGGGPSGLYASFYAGLRDMSVRLIDvQSELGG----------KMRIYPEKIIWDIGGIAPKpcheilkdtikqGLY 72
Cdd:PRK06292   5 DVIVIGAGPAGYVAARRAAKLGKKVALIE-KGPLGGtclnvgcipsKALIAAAEAFHEAKHAEEF------------GIH 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  73 FkPEVHLN-ERVVDiRKKAERHFEVE-TEAGEIYTSKAVIIAIGAGIINPKQLDVKGvERYQLtnlHYVV---------- 140
Cdd:PRK06292  72 A-DGPKIDfKKVMA-RVRRERDRFVGgVVEGLEKKPKIDKIKGTARFVDPNTVEVNG-ERIEA---KNIViatgsrvppi 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 141 -QSYRRFKD---------------KDVLISGGGNTALDWAHDIAKIAKSVTVVYRKE--------DVSGhEAMKTLVTDL 196
Cdd:PRK06292 146 pGVWLILGDrlltsddafeldklpKSLAVIGGGVIGLELGQALSRLGVKVTVFERGDrilpledpEVSK-QAQKILSKEF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 197 NVKLcpKTRIKyLVGNDDEthisEVVLEHVESGDTHTVKFDDVIISHGfDRCNT--L-LSETSSKLDmhDDCRVKGFGNT 273
Cdd:PRK06292 225 KIKL--GAKVT-SVEKSGD----EKVEELEKGGKTETIEADYVLVATG-RRPNTdgLgLENTGIELD--ERGRPVVDEHT 294

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 995475898 274 TTSIPGIYACGDIV-----YHDAKSH-LIAsafsdGANAANLAKTYIQPDA 318
Cdd:PRK06292 295 QTSVPGIYAAGDVNgkpplLHEAADEgRIA-----AENAAGDVAGGVRYHP 340
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 66-310 3.30e-04

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 42.33  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  66 TIKQGLyfkpEVHLNERVVDIRKKAE----RHFEVETEAGEIYTSKAVIIAIGAGIINPKQLDVKGVerYQLTNLH---Y 138
Cdd:PRK09564  66 FIKSGI----DVKTEHEVVKVDAKNKtitvKNLKTGSIFNDTYDKLMIATGARPIIPPIKNINLENV--YTLKSMEdglA 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 139 VVQSYRRFKDKDVLISGGGNTALDWAHDIAKIAKSVTVVYRKEDVSGH-------EAMKTLVTDLNVKLCPKTRIKYLVG 211
Cdd:PRK09564 140 LKELLKDEEIKNIVIIGAGFIGLEAVEAAKHLGKNVRIIQLEDRILPDsfdkeitDVMEEELRENGVELHLNEFVKSLIG 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 212 NDDETHISEvvlehvesgDTHTVKFDDVIISHGFDRCNTLLSETSSKLDMHDDCRVKGFGNttTSIPGIYACGD--IVYH 289
Cdd:PRK09564 220 EDKVEGVVT---------DKGEYEADVVIVATGVKPNTEFLEDTGLKTLKNGAIIVDEYGE--TSIENIYAAGDcaTIYN 288

                        250       260
                 ....*....|....*....|....*..
gi 995475898 290 DAKSHLIASAFSDGAN------AANLA 310
Cdd:PRK09564 289 IVSNKNVYVPLATTANklgrmvGENLA 315
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 3-287 7.04e-04

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 41.23  E-value: 7.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   3 DVTIIGGGPSGLYASFYAGLRDMSVRLIDvQSELGG----------KMRIYPEKIIWDIG-----GIAPKPCHEILKDTI 67
Cdd:COG1249    5 DLVVIGAGPGGYVAAIRAAQLGLKVALVE-KGRLGGtclnvgcipsKALLHAAEVAHEARhaaefGISAGAPSVDWAALM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  68 KqglyfkpevHLNERVVDIRKKAERHFE------------------VETEAGEIYTSKAV------IiaigagiinPKQL 123
Cdd:COG1249   84 A---------RKDKVVDRLRGGVEELLKkngvdvirgrarfvdphtVEVTGGETLTADHIviatgsR---------PRVP 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 124 DVKGV--ERY----QLTNLHYVVQSyrrfkdkdVLISGGGNTALDWAHDIAKIAKSVTVVYRK--------EDVSghEAM 189
Cdd:COG1249  146 PIPGLdeVRVltsdEALELEELPKS--------LVVIGGGYIGLEFAQIFARLGSEVTLVERGdrllpgedPEIS--EAL 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 190 KTLVTDLNVKLCPKTRIKYLVGNDDETHIsevvleHVESGDT-HTVKFDDVIISHGFdRCNT--L-LSETSSKLDMH--- 262
Cdd:COG1249  216 EKALEKEGIDILTGAKVTSVEKTGDGVTV------TLEDGGGeEAVEADKVLVATGR-RPNTdgLgLEAAGVELDERggi 288

                        330       340
                 ....*....|....*....|....*...
gi 995475898 263 ---DDCRvkgfgnttTSIPGIYACGDIV 287
Cdd:COG1249  289 kvdEYLR--------TSVPGIYAIGDVT 308
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 4-307 9.62e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 41.16  E-value: 9.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898   4 VTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRIypekiiwdigGIAPkpcHEILKDTIKQ--------GLYFkp 75
Cdd:PRK12809 313 VAVIGAGPAGLGCADILARAGVQVDVFDRHPEIGGMLTF----------GIPP---FKLDKTVLSQrreiftamGIDF-- 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898  76 evHLNERV---VDIRKKAERHFEVETEAGEIYTSKA---------VIIAIGAGIINPKQL-DVKGVERYQLTNLhyvvqs 142
Cdd:PRK12809 378 --HLNCEIgrdITFSDLTSEYDAVFIGVGTYGMMRAdlphedapgVIQALPFLTAHTRQLmGLPESEEYPLTDV------ 449

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 143 yrrfKDKDVLISGGGNTALDWAH-DIAKIAKSVTVVYRKEDVSGHEAMKTLVT--DLNVKLCPKTRIKYLVGNDDE--TH 217
Cdd:PRK12809 450 ----EGKRVVVLGGGDTTMDCLRtSIRLNAASVTCAYRRDEVSMPGSRKEVVNarEEGVEFQFNVQPQYIACDEDGrlTA 525

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995475898 218 ISEVVLEHVE------------SGDTHTVKFDDVIISHGFDRCNT-LLSETSSKLDMHDDCRV--KGFGNTTTSIPGIYA 282
Cdd:PRK12809 526 VGLIRTAMGEpgpdgrrrprpvAGSEFELPADVLIMAFGFQAHAMpWLQGSGIKLDKWGLIQTgdVGYLPTQTHLKKVFA 605

                        330       340
                 ....*....|....*....|....*
gi 995475898 283 CGDIVYhdaKSHLIASAFSDGANAA 307
Cdd:PRK12809 606 GGDAVH---GADLVVTAMAAGRQAA 627
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-41 5.84e-03

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 38.29  E-value: 5.84e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 995475898   1 MKDVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMR 41
Cdd:COG1233    3 MYDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRAR 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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