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Conserved domains on  [gi|997484969|emb|CXW75505|]
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Mn-dependent transcriptional regulator MntR [Staphylococcus aureus]

Protein Classification

metal-dependent transcriptional regulator( domain architecture ID 11442488)

metal-dependent transcriptional regulator may be activated by one or more from a variety of metal ions such as Mn, Cd, Co, Ni, and Fe, among others, and may function as an activator or repressor of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-133 2.55e-48

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


:

Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 154.59  E-value: 2.55e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 997484969   1 MLTEEKEDYLKAILTNNGDKNFVTNKILSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGVRLTEDGLTHTLDIIKRHRLL 80
Cdd:COG1321    3 MLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRLL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 997484969  81 ELFLIEILKYNWEEVHQEAEILEHRISDLFVERLDSLLNFPETCPHGGVIPRN 133
Cdd:COG1321   83 ERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPDA 135
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 142-214 3.21e-09

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


:

Pssm-ID: 461133  Cd Length: 74  Bit Score: 51.82  E-value: 3.21e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 997484969  142 TTILNYEPGDIVTIKRVRDKT-DLLIYLSSKDISIGNEVEIVSKDEMNKVIIIKRNDNVIIVSYENAMNMFAEK 214
Cdd:pfam04023   1 MPLSELKEGETARIVRIRDGDpELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVEP 74
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-133 2.55e-48

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 154.59  E-value: 2.55e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 997484969   1 MLTEEKEDYLKAILTNNGDKNFVTNKILSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGVRLTEDGLTHTLDIIKRHRLL 80
Cdd:COG1321    3 MLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRLL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 997484969  81 ELFLIEILKYNWEEVHQEAEILEHRISDLFVERLDSLLNFPETCPHGGVIPRN 133
Cdd:COG1321   83 ERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPDA 135
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 28-119 1.18e-27

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 100.37  E-value: 1.18e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 997484969    28 LSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGVRLTEDGLTHTLDIIKRHRLLELFLIEILKYNWEEVHQEAEILEHRIS 107
Cdd:smart00529   4 IAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVLGVDEEEVHEEAERLEHVLS 83

                           90
                   ....*....|..
gi 997484969   108 DLFVERLDSLLN 119
Cdd:smart00529  84 DELEDRLDRFLG 95
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 63-131 1.43e-20

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 81.36  E-value: 1.43e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 997484969   63 TEDGLTHTLDIIKRHRLLELFLIEILKYNWEEVHQEAEILEHRISDLFVERLDSLLNFPETCPHGGVIP 131
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVDVLGVDWDEVHEEAERLEHALSDELIDRLDEFLGFPETCPHGDPIP 69
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 142-214 3.21e-09

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 51.82  E-value: 3.21e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 997484969  142 TTILNYEPGDIVTIKRVRDKT-DLLIYLSSKDISIGNEVEIVSKDEMNKVIIIKRNDNVIIVSYENAMNMFAEK 214
Cdd:pfam04023   1 MPLSELKEGETARIVRIRDGDpELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVEP 74
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
7-78 5.17e-06

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 44.62  E-value: 5.17e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 997484969   7 EDYLKAI---LTNNGDKNFVTnkiLSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGVRLTEDGLTHTLDIIKRHR 78
Cdd:PRK11050  36 EDYVELIadlIAEVGEARQVD---IAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQ 107
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 142-214 1.75e-05

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 41.40  E-value: 1.75e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 997484969   142 TTILNYEPGDIVTIKRVRDKT-DLLIYLSSKDISIGNEVEIVSKDEMNKVIIIKRNDnvIIVSYENAMNMFAEK 214
Cdd:smart00899   1 MPLSELKPGEKARIVRIRDEDpELLRRLLELGLVPGTEVTVLRKAPFGPLVVRVGGE--LALRREEAEKIFVEP 72
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
148-214 9.30e-03

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 33.95  E-value: 9.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 997484969 148 EPGDIVTIKRVRDKTDLLIYLSSKDISIGNEVEIVSKDEMNKVIIIKRNDNVIIVSYENAMNMFAEK 214
Cdd:COG1918    7 KPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVEP 73
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-133 2.55e-48

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 154.59  E-value: 2.55e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 997484969   1 MLTEEKEDYLKAILTNNGDKNFVTNKILSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGVRLTEDGLTHTLDIIKRHRLL 80
Cdd:COG1321    3 MLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHRLL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 997484969  81 ELFLIEILKYNWEEVHQEAEILEHRISDLFVERLDSLLNFPETCPHGGVIPRN 133
Cdd:COG1321   83 ERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPDA 135
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 28-119 1.18e-27

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 100.37  E-value: 1.18e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 997484969    28 LSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGVRLTEDGLTHTLDIIKRHRLLELFLIEILKYNWEEVHQEAEILEHRIS 107
Cdd:smart00529   4 IAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVLGVDEEEVHEEAERLEHVLS 83

                           90
                   ....*....|..
gi 997484969   108 DLFVERLDSLLN 119
Cdd:smart00529  84 DELEDRLDRFLG 95
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 63-131 1.43e-20

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 81.36  E-value: 1.43e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 997484969   63 TEDGLTHTLDIIKRHRLLELFLIEILKYNWEEVHQEAEILEHRISDLFVERLDSLLNFPETCPHGGVIP 131
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVDVLGVDWDEVHEEAERLEHALSDELIDRLDEFLGFPETCPHGDPIP 69
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 4-60 3.26e-20

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 80.11  E-value: 3.26e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 997484969    4 EEKEDYLKAILTNNGDKNFVTNKILSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGV 60
Cdd:pfam01325   1 ESTEDYLETIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 142-214 3.21e-09

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 51.82  E-value: 3.21e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 997484969  142 TTILNYEPGDIVTIKRVRDKT-DLLIYLSSKDISIGNEVEIVSKDEMNKVIIIKRNDNVIIVSYENAMNMFAEK 214
Cdd:pfam04023   1 MPLSELKEGETARIVRIRDGDpELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVEP 74
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
7-78 5.17e-06

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 44.62  E-value: 5.17e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 997484969   7 EDYLKAI---LTNNGDKNFVTnkiLSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGVRLTEDGLTHTLDIIKRHR 78
Cdd:PRK11050  36 EDYVELIadlIAEVGEARQVD---IAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQ 107
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
23-78 1.01e-05

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 43.81  E-value: 1.01e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 997484969  23 VTNKILSQFLNIKPPSVSEMVGRLEKAGYVETKP------YKGVRLTEDGLTHTLDIIKRHR 78
Cdd:COG1846   53 LTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPdpedrrAVLVRLTEKGRALLEEARPALE 114
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 142-214 1.75e-05

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 41.40  E-value: 1.75e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 997484969   142 TTILNYEPGDIVTIKRVRDKT-DLLIYLSSKDISIGNEVEIVSKDEMNKVIIIKRNDnvIIVSYENAMNMFAEK 214
Cdd:smart00899   1 MPLSELKPGEKARIVRIRDEDpELLRRLLELGLVPGTEVTVLRKAPFGPLVVRVGGE--LALRREEAEKIFVEP 72
PRK03902 PRK03902
transcriptional regulator MntR;
1-66 2.24e-05

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 42.68  E-value: 2.24e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 997484969   1 MLTEEKEDYLKAILTNNGDKNFVTNKILSQFLNIKPPSVSEMVGRLEKAGYVETKPYKGVRLTEDG 66
Cdd:PRK03902   1 MPTPSMEDYIEQIYLLIEEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKG 66
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-56 1.27e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 36.03  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*....
gi 997484969   28 LSQFLNIKPPSVSEMVGRLEKAGYVETKP 56
Cdd:pfam12802  25 LARRLGISKQTVSRLVKRLEAKGLVEREP 53
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
28-66 2.38e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.03  E-value: 2.38e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 997484969    28 LSQFLNIKPPSVSEMVGRLEKAGYVETKPYKG------VRLTEDG 66
Cdd:smart00347  30 LAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEdrrsvlVSLTEEG 74
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
148-214 9.30e-03

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 33.95  E-value: 9.30e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 997484969 148 EPGDIVTIKRVRDKTDLLIYLSSKDISIGNEVEIVSKDEMNKVIIIKRNDNVIIVSYENAMNMFAEK 214
Cdd:COG1918    7 KPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVEP 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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