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Conserved domains on  [gi|996919736|emb|CXQ06916|]
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sugar kinase [Staphylococcus aureus]

Protein Classification

NAD(P)H-hydrate dehydratase( domain architecture ID 10000556)

ADP-dependent NAD(P)H-hydrate dehydratase catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 9-270 1.39e-93

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


:

Pssm-ID: 439833  Cd Length: 280  Bit Score: 277.00  E-value: 1.39e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   9 IPKRKENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTKMLTKMIEM 88
Cdd:COG0063   14 LPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVPESAAPAVAAALPELMVIPLPEEDELLELLER 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  89 TDSILIGPGLGVDFKGNNAITFLLQNIQphQNLIVDGDAITIFSKLKPQL--PTCRVIFTPHLKEWERLSGIPIEEQTYE 166
Cdd:COG0063   94 ADAVVIGPGLGRDEETRELLRALLEAAD--KPLVLDADALNLLAEDPELLaaLPAPTVLTPHPGEFARLLGCSVAEIQAD 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 167 R---NREAVDRLGATVVLKKHGTEIFFKDED-FKLTIGSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIG 242
Cdd:COG0063  172 RleaAREAAKRYGAVVVLKGAGTVIAAPDGRvYINPTGNPGLATAGSGDVLAGIIAGLLAQGLDPFEAAAAGVYLHGLAG 251

                        250       260
                 ....*....|....*....|....*....
gi 996919736 243 ENLAKD-MYVVPPSRLINEIPYAMKQLES 270
Cdd:COG0063  252 DLAAEErGRGLLASDLIEALPAALRELLE 280
 
Name Accession Description Interval E-value
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 9-270 1.39e-93

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 277.00  E-value: 1.39e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   9 IPKRKENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTKMLTKMIEM 88
Cdd:COG0063   14 LPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVPESAAPAVAAALPELMVIPLPEEDELLELLER 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  89 TDSILIGPGLGVDFKGNNAITFLLQNIQphQNLIVDGDAITIFSKLKPQL--PTCRVIFTPHLKEWERLSGIPIEEQTYE 166
Cdd:COG0063   94 ADAVVIGPGLGRDEETRELLRALLEAAD--KPLVLDADALNLLAEDPELLaaLPAPTVLTPHPGEFARLLGCSVAEIQAD 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 167 R---NREAVDRLGATVVLKKHGTEIFFKDED-FKLTIGSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIG 242
Cdd:COG0063  172 RleaAREAAKRYGAVVVLKGAGTVIAAPDGRvYINPTGNPGLATAGSGDVLAGIIAGLLAQGLDPFEAAAAGVYLHGLAG 251

                        250       260
                 ....*....|....*....|....*....
gi 996919736 243 ENLAKD-MYVVPPSRLINEIPYAMKQLES 270
Cdd:COG0063  252 DLAAEErGRGLLASDLIEALPAALRELLE 280
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 14-262 9.09e-89

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 264.09  E-value: 9.09e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  14 ENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTK--MLTKMIEMTDS 91
Cdd:cd01171    1 PDSHKGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATPPEAAAVIKSYSPELMVHPLLETDieELLELLERADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  92 ILIGPGLGVDFKGNNAITFLLQNIQPhqnLIVDGDAITIFSK-LKPQLPTCRVIFTPHLKEWERLSGIPIEEQTYER--- 167
Cdd:cd01171   81 VVIGPGLGRDEEAAEILEKALAKDKP---LVLDADALNLLADePSLIKRYGPVVLTPHPGEFARLLGALVEEIQADRlaa 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 168 NREAVDRLGATVVLKKHGTEIFFKDEDFKL-TIGSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIGENLA 246
Cdd:cd01171  158 AREAAAKLGATVVLKGAVTVIADPDGRVYVnPTGNPGLATGGSGDVLAGIIAALLAQGLSPLEAAALAVYLHGLAGDLAA 237

                        250
                 ....*....|....*..
gi 996919736 247 KDM-YVVPPSRLINEIP 262
Cdd:cd01171  238 KKKgAGLTAADLVAEIP 254
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 24-262 7.87e-61

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 192.19  E-value: 7.87e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   24 ILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTKMLTKMIEMTDSILIGPGLGVDFK 103
Cdd:pfam01256   1 VLVIGGSKDYTGAPLLAALAALRSGAGLVSVATDSEAIAVLKSPLPEVMVHPLPETSSILEKLSRYDAVVIGPGLGRDEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  104 GNNAITFLLQNIQPhqnLIVDGDAITIFSKL-KPQLPTCRVIFTPHLKEWERLSGIPI--EEQTYERNREAVDRLGATVV 180
Cdd:pfam01256  81 GKAALEEVLAKDCP---LVIDADALNLLAINnEKPAREGPTVLTPHPGEFERLCGLAGilGDDRLEAARELAQKLNGTIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  181 LKKHGTEIFFKDED-FKLTIGSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIGENLAKDMYV-VPPSRLI 258
Cdd:pfam01256 158 LKGNVTVIAAPGGEvWINSTGNSALAKGGSGDVLAGLIGGLLAQNEDPYDAAIAAAWLHGAASDLAAENHGVyMLPTLLS 237


                  ....
gi 996919736  259 NEIP 262
Cdd:pfam01256 238 KIIP 241
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 9-267 6.81e-57

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 183.35  E-value: 6.81e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736    9 IPKRKENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTK-MLTKMIE 87
Cdd:TIGR00196  12 LPLRDPNSHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVAAPENVITLINSVSPELIVHRLMWKVdEDEELLE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   88 MTDSILIGPGLGVDFKGNNAITFLLQNIQPhqnLIVDGDAitIFSKLKPQLPTCRVIFTPHLKEWERLSGIPIEE-QTYE 166
Cdd:TIGR00196  92 RYDVVVIGPGLGQDPSFKKAVEEVLELDKP---VVLDADA--LNLLTYNQKREGEVILTPHPGEFKRLLGVNEIQgDRLE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  167 RNREAVDRLGATVVLKKHGTEIFFKDEDFKLTI-GSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIGENL 245
Cdd:TIGR00196 167 AAQDIAQKLQAVVVLKGAADVIAAPDGDLWINKtGNAALAKGGTGDVLAGLIGGLLAQNLDPFDAACNAAFAHGLAGDLA 246

                         250       260
                  ....*....|....*....|....
gi 996919736  246 AKD--MYVVPPSRLINEIPYAMKQ 267
Cdd:TIGR00196 247 LKNhgAYGLTALDLIEKIPRVCKR 270
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 9-230 1.19e-40

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 146.74  E-value: 1.19e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   9 IPKRKENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDtKMLTKMIEM 88
Cdd:PRK10565 242 LKPRRPTSHKGDHGRLLIIGGDHGTAGAIRMAGEAALRSGAGLVRVLTRSENIAPLLTARPELMVHELTP-DSLEESLEW 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  89 TDSILIGPGLGVDFKGNNAITfLLQNIQphQNLIVDGDAITIFSkLKPQLPTCRVIfTPHLKEWERLSGIPIEEQTYER- 167
Cdd:PRK10565 321 ADVVVIGPGLGQQEWGKKALQ-KVENFR--KPMLWDADALNLLA-INPDKRHNRVI-TPHPGEAARLLGCSVAEIESDRl 395

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 996919736 168 --NREAVDRLGATVVLKKHGTEIffKDEDFKLTI---GSPAMATGGMGDTLAGMITSFVGQFDNLKEA 230
Cdd:PRK10565 396 lsARRLVKRYGGVVVLKGAGTVI--AAEPDALAIidvGNAGMASGGMGDVLSGIIGALLGQKLSPYDA 461
 
Name Accession Description Interval E-value
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 9-270 1.39e-93

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 277.00  E-value: 1.39e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   9 IPKRKENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTKMLTKMIEM 88
Cdd:COG0063   14 LPPRPPDSHKGSRGHVLVIGGSRGYPGAAVLAARAALRAGAGLVTVAVPESAAPAVAAALPELMVIPLPEEDELLELLER 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  89 TDSILIGPGLGVDFKGNNAITFLLQNIQphQNLIVDGDAITIFSKLKPQL--PTCRVIFTPHLKEWERLSGIPIEEQTYE 166
Cdd:COG0063   94 ADAVVIGPGLGRDEETRELLRALLEAAD--KPLVLDADALNLLAEDPELLaaLPAPTVLTPHPGEFARLLGCSVAEIQAD 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 167 R---NREAVDRLGATVVLKKHGTEIFFKDED-FKLTIGSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIG 242
Cdd:COG0063  172 RleaAREAAKRYGAVVVLKGAGTVIAAPDGRvYINPTGNPGLATAGSGDVLAGIIAGLLAQGLDPFEAAAAGVYLHGLAG 251

                        250       260
                 ....*....|....*....|....*....
gi 996919736 243 ENLAKD-MYVVPPSRLINEIPYAMKQLES 270
Cdd:COG0063  252 DLAAEErGRGLLASDLIEALPAALRELLE 280
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 14-262 9.09e-89

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 264.09  E-value: 9.09e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  14 ENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTK--MLTKMIEMTDS 91
Cdd:cd01171    1 PDSHKGSRGRVLVIGGSRGYTGAAYLAALAALRAGAGLVTVATPPEAAAVIKSYSPELMVHPLLETDieELLELLERADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  92 ILIGPGLGVDFKGNNAITFLLQNIQPhqnLIVDGDAITIFSK-LKPQLPTCRVIFTPHLKEWERLSGIPIEEQTYER--- 167
Cdd:cd01171   81 VVIGPGLGRDEEAAEILEKALAKDKP---LVLDADALNLLADePSLIKRYGPVVLTPHPGEFARLLGALVEEIQADRlaa 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 168 NREAVDRLGATVVLKKHGTEIFFKDEDFKL-TIGSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIGENLA 246
Cdd:cd01171  158 AREAAAKLGATVVLKGAVTVIADPDGRVYVnPTGNPGLATGGSGDVLAGIIAALLAQGLSPLEAAALAVYLHGLAGDLAA 237

                        250
                 ....*....|....*..
gi 996919736 247 KDM-YVVPPSRLINEIP 262
Cdd:cd01171  238 KKKgAGLTAADLVAEIP 254
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 24-262 7.87e-61

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 192.19  E-value: 7.87e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   24 ILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTKMLTKMIEMTDSILIGPGLGVDFK 103
Cdd:pfam01256   1 VLVIGGSKDYTGAPLLAALAALRSGAGLVSVATDSEAIAVLKSPLPEVMVHPLPETSSILEKLSRYDAVVIGPGLGRDEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  104 GNNAITFLLQNIQPhqnLIVDGDAITIFSKL-KPQLPTCRVIFTPHLKEWERLSGIPI--EEQTYERNREAVDRLGATVV 180
Cdd:pfam01256  81 GKAALEEVLAKDCP---LVIDADALNLLAINnEKPAREGPTVLTPHPGEFERLCGLAGilGDDRLEAARELAQKLNGTIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  181 LKKHGTEIFFKDED-FKLTIGSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIGENLAKDMYV-VPPSRLI 258
Cdd:pfam01256 158 LKGNVTVIAAPGGEvWINSTGNSALAKGGSGDVLAGLIGGLLAQNEDPYDAAIAAAWLHGAASDLAAENHGVyMLPTLLS 237


                  ....
gi 996919736  259 NEIP 262
Cdd:pfam01256 238 KIIP 241
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 9-267 6.81e-57

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 183.35  E-value: 6.81e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736    9 IPKRKENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTK-MLTKMIE 87
Cdd:TIGR00196  12 LPLRDPNSHKGQYGRVLIIGGSDDYSGAPLLAALAALRAGAGLVTVAAPENVITLINSVSPELIVHRLMWKVdEDEELLE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   88 MTDSILIGPGLGVDFKGNNAITFLLQNIQPhqnLIVDGDAitIFSKLKPQLPTCRVIFTPHLKEWERLSGIPIEE-QTYE 166
Cdd:TIGR00196  92 RYDVVVIGPGLGQDPSFKKAVEEVLELDKP---VVLDADA--LNLLTYNQKREGEVILTPHPGEFKRLLGVNEIQgDRLE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  167 RNREAVDRLGATVVLKKHGTEIFFKDEDFKLTI-GSPAMATGGMGDTLAGMITSFVGQFDNLKEAVMSATYTHSFIGENL 245
Cdd:TIGR00196 167 AAQDIAQKLQAVVVLKGAADVIAAPDGDLWINKtGNAALAKGGTGDVLAGLIGGLLAQNLDPFDAACNAAFAHGLAGDLA 246

                         250       260
                  ....*....|....*....|....
gi 996919736  246 AKD--MYVVPPSRLINEIPYAMKQ 267
Cdd:TIGR00196 247 LKNhgAYGLTALDLIEKIPRVCKR 270
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 9-230 1.19e-40

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 146.74  E-value: 1.19e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   9 IPKRKENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDtKMLTKMIEM 88
Cdd:PRK10565 242 LKPRRPTSHKGDHGRLLIIGGDHGTAGAIRMAGEAALRSGAGLVRVLTRSENIAPLLTARPELMVHELTP-DSLEESLEW 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  89 TDSILIGPGLGVDFKGNNAITfLLQNIQphQNLIVDGDAITIFSkLKPQLPTCRVIfTPHLKEWERLSGIPIEEQTYER- 167
Cdd:PRK10565 321 ADVVVIGPGLGQQEWGKKALQ-KVENFR--KPMLWDADALNLLA-INPDKRHNRVI-TPHPGEAARLLGCSVAEIESDRl 395

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 996919736 168 --NREAVDRLGATVVLKKHGTEIffKDEDFKLTI---GSPAMATGGMGDTLAGMITSFVGQFDNLKEA 230
Cdd:PRK10565 396 lsARRLVKRYGGVVVLKGAGTVI--AAEPDALAIidvGNAGMASGGMGDVLSGIIGALLGQKLSPYDA 461
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 9-223 8.17e-15

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 73.75  E-value: 8.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736   9 IPKRKENSHKGDYGKILLIGGSANLGGAIMLAARACVFSGSGLITVATHPTNHSALHSRCPEAMVIDINDTKMLTKMIEM 88
Cdd:COG0062  231 LPPRRRSHHKGGGGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAALLAALPEAMALALDDDEELLLLLAA 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  89 TDSILIGPGLGVDFKGNNAITFLLQNIQPHQNLIVDGDAITIFSKLKPQLPTCRV---IFTPHLKEWERLSGIPIEEQTY 165
Cdd:COG0062  311 AVVVAGGGGGGGGGAGGGLLLLLLLLLLLLVLLAAALLLLLALAAALLLLLLLPPplaAALLLLRLLTELLELRAAAAAL 390

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 996919736 166 ERNREAVDRLGATVVLKKHGTEIFFKDEDFKLTIGSPAMATGGMGDTLAGMITSFVGQ 223
Cdd:COG0062  391 LAAAAAAAAVAAAAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGLLA 448
Phos_pyr_kin pfam08543
Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate ...
 123-253 4.37e-07

Phosphomethylpyrimidine kinase; This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes.


Pssm-ID: 430062 [Multi-domain]  Cd Length: 246  Bit Score: 49.79  E-value: 4.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  123 VDGDAI-TIFSKLkpqLPTCRVIfTPHLKEWERLSGIPIE-EQTYERNREAVDRLGATVVLKK--HGTE-------IFFK 191
Cdd:pfam08543 104 LDDEAIeALKEEL---LPLATLI-TPNLPEAEALTGRKIKtLEDMKEAAKKLLALGAKAVLIKggHLEGeeavvtdVLYD 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 996919736  192 DEDFkLTIGSPAMATG---GMGDTLAGMITSFVGQFDNLKEAVMSAT-YTHSFIGENLAKDMYVVP 253
Cdd:pfam08543 180 GGGF-YTLEAPRIPTKnthGTGCTLSAAIAANLAKGLSLPEAVREAKeYVTEAIRDALNLGKGHGP 244
PRK06427 PRK06427
bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed
 116-234 1.42e-05

bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed


Pssm-ID: 180561 [Multi-domain]  Cd Length: 266  Bit Score: 45.12  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 116 QPHQNLIVD-------------GDAI-TIFSKLkpqLPTCRVIfTPHLKEWERLSGIPI--EEQTYERNREAVDRLGATV 179
Cdd:PRK06427  98 YPIPPVVLDpvmiaksgdpllaDDAVaALRERL---LPLATLI-TPNLPEAEALTGLPIadTEDEMKAAARALHALGCKA 173

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 996919736 180 VLKK--------HGTEIFFkDEDFKLTIGSPAMATG---GMGDTLAGMITSFVGQFDNLKEAVMSA 234
Cdd:PRK06427 174 VLIKgghlldgeESVDWLF-DGEGEERFSAPRIPTKnthGTGCTLSAAIAAELAKGASLLDAVQTA 238
PRK12616 PRK12616
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
23-253 2.10e-04

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 183624  Cd Length: 270  Bit Score: 41.95  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  23 KILLIGGSANLGGAIMLA-----ARACVFSGSGL-ITVATHPTNHSalhsrcpEAMVIDINDTKMLTKMIEMTDsiligp 96
Cdd:PRK12616   5 KALTIAGSDSSGGAGIQAdlktfQEKNVYGMTALtVVVAMDPENSW-------DHQVFPIDTDTIRAQLSTIVD------ 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  97 GLGVD------FKGNNAITFLLQNIQPHQ--NLIVD------GDAITIFSK----LKPQLPTCRVIFTPHLKEWERLSGI 158
Cdd:PRK12616  72 GIGVDamktgmLPTVDIIELAADTIKEKQlkNVVIDpvmvckGANEVLYPEhaeaLREQLAPLATVITPNLFEAGQLSGM 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 159 PiEEQTYERNREAVDR---LGATVVLKKHG--------TEIFFKDEDFKL----TIGSPamATGGMGDTLAGMITSFVGQ 223
Cdd:PRK12616 152 G-EIKTVEQMKEAAKKiheLGAQYVVITGGgklkhekaVDVLYDGETAEVleseMIDTP--YTHGAGCTFSAAVTAELAK 228

                        250       260       270
                 ....*....|....*....|....*....|.
gi 996919736 224 FDNLKEAVMSA-TYTHSFIGENLAKDMYVVP 253
Cdd:PRK12616 229 GSEVKEAIYAAkEFITAAIKESFPLNQYVGP 259
pyridoxal_pyridoxamine_kinase cd01173
Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5 ...
 144-237 2.10e-03

Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and require its precursors in the form of vitamin B6 (pyridoxal, pyridoxine, and pyridoxamine) from their diet. Pyridoxal kinase encoding genes are also found in many other species including yeast and bacteria.


Pssm-ID: 238578 [Multi-domain]  Cd Length: 254  Bit Score: 38.72  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 144 IFTPHLKEWERLSGIPIEEQtyERNREAVDRL----GATVVLkkhgTEIFFKDEDFKLTIGSPAMATG------------ 207
Cdd:cd01173  139 IITPNQFELELLTGKKINDL--EDAKAAARALhakgPKTVVV----TSVELADDDRIEMLGSTATEAWlvqrpkipfpay 212

                         90       100       110
                 ....*....|....*....|....*....|..
gi 996919736 208 --GMGDTLAGMITSFVGQFDNLKEAVMSATYT 237
Cdd:cd01173  213 fnGTGDLFAALLLARLLKGKSLAEALEKALNF 244
PRK12412 PRK12412
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
23-253 2.75e-03

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 183512 [Multi-domain]  Cd Length: 268  Bit Score: 38.41  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  23 KILLIGGSANLGGAIMLA-----ARACVFSGSGLITVATHPTNHSALHSRCPeamvIDINDTK-MLTKMIEmtdsiligp 96
Cdd:PRK12412   3 KALTIAGSDTSGGAGIQAdlktfQELGVYGMTSLTTIVTMDPHNGWAHNVFP----IPASTLKpQLETTIE--------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736  97 GLGVD------FKGNNAITFLLQNIQPHQ--NLIVDGDAITIFSK--LKPQLPTC--------RVIFTPHLKEWERLSGI 158
Cdd:PRK12412  70 GVGVDalktgmLGSVEIIEMVAETIEKHNfkNVVVDPVMVCKGADeaLHPETNDClrdvlvpkALVVTPNLFEAYQLSGV 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 159 PIEeqTYERNREAVDR---LGATVVLKKHGTEI--------FFKDEDFKLTIGS--PAMATGGMGDTLAGMITSFVGQFD 225
Cdd:PRK12412 150 KIN--SLEDMKEAAKKihaLGAKYVLIKGGSKLgtetaidvLYDGETFDLLESEkiDTTNTHGAGCTYSAAITAELAKGK 227

                        250       260
                 ....*....|....*....|....*....
gi 996919736 226 NLKEAVMSA-TYTHSFIGENLAKDMYVVP 253
Cdd:PRK12412 228 PVKEAVKTAkEFITAAIRYSFKINEYVGP 256
PRK12413 PRK12413
bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;
138-234 5.79e-03

bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase;


Pssm-ID: 183513 [Multi-domain]  Cd Length: 253  Bit Score: 37.35  E-value: 5.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 138 LPTCRVIfTPHLKEWERLSGIPIEeqTYERNREAVD---RLGA-TVVLK-------KHGTEIFFKDEDFKlTIGSPAMAT 206
Cdd:PRK12413 127 FPYVTVI-TPNLVEAELLSGKEIK--TLEDMKEAAKklyDLGAkAVVIKggnrlsqKKAIDLFYDGKEFV-ILESPVLEK 202

                         90       100       110
                 ....*....|....*....|....*....|
gi 996919736 207 G--GMGDTLAGMITSFVGQFDNLKEAVMSA 234
Cdd:PRK12413 203 NniGAGCTFASSIASQLVKGKSPLEAVKNS 232
ThiD COG0351
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; ...
 116-241 8.15e-03

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [Coenzyme transport and metabolism]; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase is part of the Pathway/BioSystem: Thiamine biosynthesis


Pssm-ID: 440120 [Multi-domain]  Cd Length: 254  Bit Score: 36.94  E-value: 8.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996919736 116 QPHQNLIVD-------------GDAI-TIFSKLkpqLPTCRVIfTPHLKEWERLSGIPIEeqTYERNREAVDRLGAT--- 178
Cdd:COG0351   91 YPLVPVVLDpvmvaksgdrlldEDAVeALRELL---LPLATVV-TPNLPEAEALLGIEIT--TLDDMREAAKALLELgak 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 996919736 179 -VVLK------KHGTEIFFKDEDFkLTIGSPAMATG---GMGDTLAGMITSFVGQFDNLKEAVMSA-TYTHSFI 241
Cdd:COG0351  165 aVLVKgghlpgDEAVDVLYDGDGV-REFSAPRIDTGnthGTGCTLSSAIAALLAKGLDLEEAVREAkEYVTQAI 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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