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Conserved domains on  [gi|996915547|emb|CXP68659|]
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Glucose-6-phosphate 1-dehydrogenase [Staphylococcus aureus]

Protein Classification

glucose-6-phosphate dehydrogenase( domain architecture ID 11481539)

glucose-6-phosphate dehydrogenase (NADP(+)) catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone

CATH:  3.40.50.720
EC:  1.1.1.49
Gene Ontology:  GO:0004345|GO:0050661|GO:0006006
PubMed:  39259139|24720642
SCOP:  4000091

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-492 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


:

Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 838.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   1 MSTKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVK---DTNKID 77
Cdd:PRK05722   1 MRLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARtpfDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  78 AFMEHVFYHRHDVSNEESYQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSD 157
Cdd:PRK05722  81 RFLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 158 LKSAEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGAL 237
Cdd:PRK05722 161 LASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGAL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 238 KDMVQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSN 317
Cdd:PRK05722 241 RDMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDST 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 318 TPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNT 397
Cdd:PRK05722 321 TETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 398 QGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLE 477
Cdd:PRK05722 401 EGMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEA 480

                        490
                 ....*....|....*
gi 996915547 478 SDLLLARDGNHWWDD 492
Cdd:PRK05722 481 ADALLARDGRSWREP 495
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-492 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 838.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   1 MSTKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVK---DTNKID 77
Cdd:PRK05722   1 MRLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARtpfDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  78 AFMEHVFYHRHDVSNEESYQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSD 157
Cdd:PRK05722  81 RFLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 158 LKSAEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGAL 237
Cdd:PRK05722 161 LASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGAL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 238 KDMVQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSN 317
Cdd:PRK05722 241 RDMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDST 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 318 TPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNT 397
Cdd:PRK05722 321 TETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 398 QGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLE 477
Cdd:PRK05722 401 EGMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEA 480

                        490
                 ....*....|....*
gi 996915547 478 SDLLLARDGNHWWDD 492
Cdd:PRK05722 481 ADALLARDGRSWREP 495
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 1-492 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 820.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   1 MSTKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVK---DTNKID 77
Cdd:COG0364    1 MTQMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRkpfDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  78 AFMEHVFYHRHDVSNEESYQELLDFSNELDSQFElKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSD 157
Cdd:COG0364   81 RFLERLHYVSGDFTDPEGYERLKELLEELDEERT-PGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 158 LKSAEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGAL 237
Cdd:COG0364  160 LASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 238 KDMVQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSN 317
Cdd:COG0364  240 RDMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDST 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 318 TPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNT 397
Cdd:COG0364  320 TETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPG 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 398 QGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLE 477
Cdd:COG0364  400 LGMRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEA 479

                        490
                 ....*....|....*
gi 996915547 478 SDLLLARDGNHWWDD 492
Cdd:COG0364  480 ADALLARDGRSWREP 494
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 9-491 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 660.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547    9 PCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVKDT--NKIDAFMEHVFYH 86
Cdd:TIGR00871   2 PCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEidEQWDEFAQRLSYV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   87 RHDVSNEESYQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLKSAEALNN 166
Cdd:TIGR00871  82 SGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELNK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  167 QIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDMVQNHML 246
Cdd:TIGR00871 162 ALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  247 QMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDvkKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSNTPTFVSGKL 326
Cdd:TIGR00871 242 QLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALKL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  327 TIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDK-LLDSNLLVINIQPNEGVSLHLNAKKNTQGIETEPV 405
Cdd:TIGR00871 320 EIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdANPRNALVIRIQPDEGVYLKFNAKKPGLNFETRPV 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  406 QLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMV-DPEFPNYESGTNGPLESDLLLAR 484
Cdd:TIGR00871 400 KLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANkGPSPPNYPAGSWGPKEADELIRK 479


                  ....*..
gi 996915547  485 DGNHWWD 491
Cdd:TIGR00871 480 DGRSWRK 486
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
194-490 5.60e-174

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 490.80  E-value: 5.60e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  194 VLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDMVQNHMLQMVALLAMEAPISLNSEDIRAEKVKVL 273
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  274 KSLRHFQSEDVKKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSNTPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQV 353
Cdd:pfam02781  82 RSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  354 VVEFKEVPMNLYYETDKlLDSNLLVINIQPNEGVSLHLNAKKNTQGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKG 433
Cdd:pfam02781 162 RIQFKDVPHNLFRDPGT-LPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMRG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 996915547  434 DATNFTHWEELKSTWKFVDAIQDEWNmvDPEFPNYESGTNGPLESDLLLARDGNHWW 490
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPILEAWD--EEKPPPYPAGSWGPKAADELLARDGRKWR 295
 
Name Accession Description Interval E-value
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 1-492 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 838.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   1 MSTKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVK---DTNKID 77
Cdd:PRK05722   1 MRLPRTAEPCDLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDFREVVREALKEFARtpfDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  78 AFMEHVFYHRHDVSNEESYQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSD 157
Cdd:PRK05722  81 RFLSRLYYVSGDVTDPESYERLKELLEELDEERGTGGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 158 LKSAEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGAL 237
Cdd:PRK05722 161 LASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGAL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 238 KDMVQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSN 317
Cdd:PRK05722 241 RDMVQNHLLQLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVKENTVRGQYTAGWIGGKPVPGYREEEGVNPDST 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 318 TPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNT 397
Cdd:PRK05722 321 TETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEESAEELGPNKLVIRIQPDEGISLRFNAKVPG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 398 QGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLE 477
Cdd:PRK05722 401 EGMELRPVKLDFSYSEAFGEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEA 480

                        490
                 ....*....|....*
gi 996915547 478 SDLLLARDGNHWWDD 492
Cdd:PRK05722 481 ADALLARDGRSWREP 495
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 1-492 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 820.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   1 MSTKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVK---DTNKID 77
Cdd:COG0364    1 MTQMRPAEPCDLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEFREEVREALEEFSRkpfDEEVWE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  78 AFMEHVFYHRHDVSNEESYQELLDFSNELDSQFElKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSD 157
Cdd:COG0364   81 RFLERLHYVSGDFTDPEGYERLKELLEELDEERT-PGNRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 158 LKSAEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGAL 237
Cdd:COG0364  160 LASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 238 KDMVQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSN 317
Cdd:COG0364  240 RDMVQNHLLQLLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVAENTVRGQYTAGWIGGEPVPGYREEPGVAPDST 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 318 TPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNT 397
Cdd:COG0364  320 TETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEELPPNRLVIRIQPDEGISLRFNAKVPG 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 398 QGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLE 477
Cdd:COG0364  400 LGMRLRPVSLDFSYSDAFGERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEA 479

                        490
                 ....*....|....*
gi 996915547 478 SDLLLARDGNHWWDD 492
Cdd:COG0364  480 ADALLARDGRSWREP 494
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 9-491 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 660.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547    9 PCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVKDT--NKIDAFMEHVFYH 86
Cdd:TIGR00871   2 PCILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRKVVREAIIKFETDEidEQWDEFAQRLSYV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   87 RHDVSNEESYQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLKSAEALNN 166
Cdd:TIGR00871  82 SGDVDDDESYDSLAELLEQLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDLASAQELNK 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  167 QIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDMVQNHML 246
Cdd:TIGR00871 162 ALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  247 QMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDvkKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSNTPTFVSGKL 326
Cdd:TIGR00871 242 QLLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDD--NNTVRGQYGAGEIGGVSVPGYLEEEGVDKDSNTETFAALKL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  327 TIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDK-LLDSNLLVINIQPNEGVSLHLNAKKNTQGIETEPV 405
Cdd:TIGR00871 320 EIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdANPRNALVIRIQPDEGVYLKFNAKKPGLNFETRPV 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  406 QLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMV-DPEFPNYESGTNGPLESDLLLAR 484
Cdd:TIGR00871 400 KLDFSYASRFGELLPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANkGPSPPNYPAGSWGPKEADELIRK 479


                  ....*..
gi 996915547  485 DGNHWWD 491
Cdd:TIGR00871 480 DGRSWRK 486
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
9-494 0e+00

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 597.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   9 PCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVKDtnKIDA-----FMEHV 83
Cdd:PRK12853   8 PCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQWRARVRESLRAFGAD--GFDDavwdrLAARL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  84 FYHRHDVSNEESYQELLDfsnELDSQfelkGNRLFYLAMAPQFFGVISDYLKSSGLTDtkGFKRLVIEKPFGSDLKSAEA 163
Cdd:PRK12853  86 SYVQGDVTDPADYARLAE---ALGPG----GNPVFYLAVPPSLFAPVVENLGAAGLLP--EGRRVVLEKPFGHDLASARA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 164 LNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDMVQN 243
Cdd:PRK12853 157 LNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQN 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 244 HMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVkkNFVRGQYGEGYIDGKQVKAYRDEDRVADDSNTPTFVS 323
Cdd:PRK12853 237 HLLQLLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDV--HTVRGQYTAGTVGGEPVPGYREEPGVDPDSRTETFVA 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 324 GKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDkLLDSNLLVINIQPNEGVSLHLNAKKNTQGIETE 403
Cdd:PRK12853 315 LKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTG-VEPPNRLVIRLQPDEGISLELNVKRPGPGMRLR 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 404 PVQLSYSMsaQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLESDLLLA 483
Cdd:PRK12853 394 PVELDADY--ADDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAADALLA 471

                        490
                 ....*....|.
gi 996915547 484 RDGNHWWDDIQ 494
Cdd:PRK12853 472 RDGRGWREPAA 482
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
194-490 5.60e-174

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 490.80  E-value: 5.60e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  194 VLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDMVQNHMLQMVALLAMEAPISLNSEDIRAEKVKVL 273
Cdd:pfam02781   2 VLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  274 KSLRHFQSEDVKKNFVRGQYGEGYIDGKQVKAYRDEDRVADDSNTPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQV 353
Cdd:pfam02781  82 RSLRPITPEDVEDNVVRGQYGAGWIGGEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  354 VVEFKEVPMNLYYETDKlLDSNLLVINIQPNEGVSLHLNAKKNTQGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKG 433
Cdd:pfam02781 162 RIQFKDVPHNLFRDPGT-LPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRFGERIPEAYERLLLDVMRG 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 996915547  434 DATNFTHWEELKSTWKFVDAIQDEWNmvDPEFPNYESGTNGPLESDLLLARDGNHWW 490
Cdd:pfam02781 241 DQTLFVRSDEVEAAWRIVDPILEAWD--EEKPPPYPAGSWGPKAADELLARDGRKWR 295
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 9-486 5.10e-148

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 432.15  E-value: 5.10e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   9 PCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQK---HVKDTNKIDAFMEHVFY 85
Cdd:PRK12854  11 PTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAFREHARDALDEfgaRKLDDGEWARFAKRLRY 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  86 HRHDVSNEESyQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKgfkRLVIEKPFGSDLKSAEALN 165
Cdd:PRK12854  91 VPGGFLSAGP-GALAAAVAAARAELGGDARLVHYLAVPPSAFLDVTRALGEAGLAEGS---RVVMEKPFGTDLASAEALN 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 166 NQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDMVQNHM 245
Cdd:PRK12854 167 AAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVTHL 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 246 LQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVkknfVRGQYgegyiDGkqvkaYRDEDRVADDSNTPTFVSGK 325
Cdd:PRK12854 247 FQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEV----VRGQY-----SG-----YRDEPGVAPDSTTETFVALK 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 326 LTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETD-KLLDSNLLVINIQPNEGVSLHLNAKKNTQGIETEP 404
Cdd:PRK12854 313 VWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFPAGSvGAQGPDHLTFDLADNSKVSLSFYGKRPGPGMRLDK 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 405 VQLSYSMSAQDKMNTV-DAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEwnmvDPEFPNYESGTNGPLESDLLLA 483
Cdd:PRK12854 393 LSLQFSLKDTGPKGDVlEAYERLILDALRGDHTLFTTADGIESLWEVSQPLLED----PPPVKPYAPGSWGPNAIHQLAA 468


                 ...
gi 996915547 484 RDG 486
Cdd:PRK12854 469 PDA 471
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 12-489 4.71e-145

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 426.47  E-value: 4.71e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  12 ITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDD--FRNQVKSSIQKHVKDTNKIDAFMEHVFYHRHD 89
Cdd:PTZ00309  57 IIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSDVErwKKETLARFFKRLDDRECHLEQFLKHISYISGS 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  90 VSNEESYQELLDFSNELDSQF---ELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTkGFKRLVIEKPFGSDLKSAEALNN 166
Cdd:PTZ00309 137 YDEDEDFKRLNKLIERMEEAFqgpEKGGNRLFYLALPPSVFASVCEGIHRGCMSKN-GWVRVIVEKPFGRDLESSEELSN 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 167 QIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDMVQNHML 246
Cdd:PTZ00309 216 QLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQNHLL 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 247 QMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVkknfVRGQYgEGYIDGKqVKAYRDEDRVADDSNTPTFVSGKL 326
Cdd:PTZ00309 296 QILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEEC----VLGQY-TASADGS-IPGYLEDEGVPKDSTTPTFAAAVL 369

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 327 TIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDklLDSNLLVINIQPNEGVSLHLNAKKNTQGIETEPVQ 406
Cdd:PTZ00309 370 HINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDD--TQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTE 447

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 407 LSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWK----FVDAIQDEwnMVDPEfpNYESGTNGPLESDLLL 482
Cdd:PTZ00309 448 LDLTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRiftpLLHQIDRG--EVKPE--PYPFGSRGPKEADELI 523

                        490
                 ....*....|...
gi 996915547 483 AR------DGNHW 489
Cdd:PTZ00309 524 KKngfkssKGYQW 536
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 12-491 1.98e-130

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 391.26  E-value: 1.98e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  12 ITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSS----IQKHVKDTNKIDAFMEHVFYHR 87
Cdd:PLN02333 120 ITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRNMVSKTltcrIDKRENCGEKMEEFLKRCFYHS 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  88 HDVSNEESYQELldfsnelDSQF-ELKG----NRLFYLAMAPQFFgviSDYLK--SSGLTDTKGFKRLVIEKPFGSDLKS 160
Cdd:PLN02333 200 GQYDSQEHFAEL-------DKKLkEHEGgrvsNRLFYLSIPPNIF---VDAVKcaSSSASSVNGWTRVIVEKPFGRDSES 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 161 AEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDM 240
Cdd:PLN02333 270 SAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDI 349

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 241 VQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVkknfVRGQYGEGYIDGKQVKAYRDEDRVADDSNTPT 320
Cdd:PLN02333 350 MQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDV----VIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPT 425

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 321 FVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLY---YETDKLLDSNLLVINIQPNEGVSLHLNAKKNT 397
Cdd:PLN02333 426 FAAAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLYnrnFGTDLDQATNELVIRVQPDEAIYLKINNKVPG 505

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 398 QGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWK-FVDAIQD-EWNMVDPEFpnYESGTNGP 475
Cdd:PLN02333 506 LGMRLDRSNLNLLYAARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWAlFTPLLKElEEKKIIPEY--YPYGSRGP 583

                        490
                 ....*....|....*.
gi 996915547 476 LESDLLLARDGNHWWD 491
Cdd:PLN02333 584 VGAHYLAARYKVRWGD 599
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 12-491 1.29e-127

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 383.21  E-value: 1.29e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  12 ITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSS----IQKHVKDTNKIDAFMEHVFYHR 87
Cdd:PLN02640  91 ITVVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRDMISSTltcrIDQRENCGDKMDQFLKRCFYHS 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  88 HDVSNEEsyqellDFSnELDSQFELK-----GNRLFYLAMAPQFFgviSDYLKSSGL--TDTKGFKRLVIEKPFGSDLKS 160
Cdd:PLN02640 171 GQYDSEE------DFA-ELNKKLKEKeagklSNRLFYLSIPPNIF---VDVVRCASLraSSENGWTRVIVEKPFGRDSES 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 161 AEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDM 240
Cdd:PLN02640 241 SGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDI 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 241 VQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVkknfVRGQYGEGYIDGKQVKAYRDEDRVADDSNTPT 320
Cdd:PLN02640 321 MQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDV----IVGQYKGHSKGGKSYPAYTDDPTVPKHSLTPT 396

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 321 FVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLY---YETDKLLDSNLLVINIQPNEGVSLHLNAKKNT 397
Cdd:PLN02640 397 FAAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYkrnFGTDLDKATNELVLRVQPDEAIYLKINNKVPG 476

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 398 QGIETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWK-FVDAIQD-EWNMVDPEFpnYESGTNGP 475
Cdd:PLN02640 477 LGMRLDRSDLNLLYRARYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWAlFTPLLKElEEKKIIPEL--YPYGSRGP 554

                        490
                 ....*....|....*.
gi 996915547 476 LESDLLLARDGNHWWD 491
Cdd:PLN02640 555 VGAHYLAAKYNVRWGD 570
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 10-486 2.63e-126

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 376.76  E-value: 2.63e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  10 CL-ITIFGATGDLSHRKLFPSIFHLYQQDNLDEH-IAIIGIGRRDITNDDFRNQVKSSIQKHVKD-TNKIDAFMEHVFYH 86
Cdd:PLN02539  17 CLsIIVLGASGDLAKKKTFPALFNLYRQGFLPPDeVHIFGYARSKITDEELRDRIRGYLKDEKNApAEAVSKFLQLIKYV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547  87 RHDVSNEESYQELldfsNELDSQFELKGN-------RLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLK 159
Cdd:PLN02539  97 SGAYDSEEGFRRL----DKEISEHEISKNsaegssrRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGKDLE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 160 SAEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKD 239
Cdd:PLN02539 173 SAEELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 240 MVQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVkknfVRGQYgEGyidgkqvkaYRDEDRVADDSNTP 319
Cdd:PLN02539 253 IIQNHLLQVLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEV----VLGQY-EG---------YRDDPTVPDDSNTP 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 320 TFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYEtdKLLDSNLLVINIQPNEGVSLHLNAKKntQG 399
Cdd:PLN02539 319 TFASVVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFKC--QKQGRNEFVIRLQPSEAMYMKLTVKQ--PG 394

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547 400 IETEPVQ----LSYSMSAQDkMNTVDAYENLLFDCLKGDATNFTHWEELKSTWK-FVDAIQD-EWNMVDPEfpNYESGTN 473
Cdd:PLN02539 395 LEMSTVQseldLSYGQRYQD-VVIPEAYERLILDTIRGDQQHFVRRDELKAAWEiFTPLLHRiDAGKVKPI--PYKQGSR 471

                        490
                 ....*....|...
gi 996915547 474 GPLESDLLLARDG 486
Cdd:PLN02539 472 GPAEADELLEKAG 484
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
14-191 8.70e-91

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 274.30  E-value: 8.70e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   14 IFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVK-DTNKIDAFMEHVFYHRHDVSN 92
Cdd:pfam00479   2 IFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEFKElDEEKWDRFLERLHYVSGDFDD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 996915547   93 EESYQELLDFSNELDSQfeLKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLKSAEALNNQIRKSF 172
Cdd:pfam00479  82 PESYEKLKERLEEHEDE--TRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESARELNDQLAKVF 159

                         170
                  ....*....|....*....
gi 996915547  173 KEEEIYRIDHYLGKDMVQN 191
Cdd:pfam00479 160 KEEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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