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Conserved domains on  [gi|995641728|emb|CXP05608|]
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truncated transposase for IS1272 [Staphylococcus aureus]

Protein Classification

transposase( domain architecture ID 1750109)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0004803|GO:0032196

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS1182 super family cl41317
IS1182 family transposase; Members of this family are transposases of the IS1182 family. ...
 22-162 2.81e-38

IS1182 family transposase; Members of this family are transposases of the IS1182 family. About two-thirds of the members of this family have an extra domain between the middle and the C-terminal domain, about 50 amino acids in size and containing four invariant Cys residues.


The actual alignment was detected with superfamily member NF033551:

Pssm-ID: 468080 [Multi-domain]  Cd Length: 437  Bit Score: 136.30  E-value: 2.81e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995641728  22 QNWKYDEFNDEFICPNNKRIGFKryayrnDRYGFKRDFKLYERDDCSACSLRHQCMKpnlKSNKKIMKNYNWEYFKAQIN 101
Cdd:NF033551 305 DDFRYDEEDDTYICPAGQRLTFK------TTSREGYREYRFDPEDCRGCPLREQCTK---SKEGRVVTRHIHEDLLEEAR 375

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 995641728 102 QKLSEPETKKIYSQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALNIRKIAA 162
Cdd:NF033551 376 ARLKTEEGKELYRKRKATVERVFAELKQWHGLRRFRLRGLEKVRAELLLTALAHNLKRLAA 436
 
Name Accession Description Interval E-value
transpos_IS1182 NF033551
IS1182 family transposase; Members of this family are transposases of the IS1182 family. ...
 22-162 2.81e-38

IS1182 family transposase; Members of this family are transposases of the IS1182 family. About two-thirds of the members of this family have an extra domain between the middle and the C-terminal domain, about 50 amino acids in size and containing four invariant Cys residues.


Pssm-ID: 468080 [Multi-domain]  Cd Length: 437  Bit Score: 136.30  E-value: 2.81e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995641728  22 QNWKYDEFNDEFICPNNKRIGFKryayrnDRYGFKRDFKLYERDDCSACSLRHQCMKpnlKSNKKIMKNYNWEYFKAQIN 101
Cdd:NF033551 305 DDFRYDEEDDTYICPAGQRLTFK------TTSREGYREYRFDPEDCRGCPLREQCTK---SKEGRVVTRHIHEDLLEEAR 375

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 995641728 102 QKLSEPETKKIYSQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALNIRKIAA 162
Cdd:NF033551 376 ARLKTEEGKELYRKRKATVERVFAELKQWHGLRRFRLRGLEKVRAELLLTALAHNLKRLAA 436
DDE_Tnp_1_6 pfam13751
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
 34-161 9.64e-22

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.


Pssm-ID: 433453 [Multi-domain]  Cd Length: 125  Bit Score: 85.47  E-value: 9.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995641728   34 ICPNNKRIGFKrYAYRNDRYGFKRDFKLYERDDCSACSLRHQCMKPnlKSNKKIMKNYNWEYFKAQINQKLSEPETKKIY 113
Cdd:pfam13751   1 ICPAGKKLTLS-TTYREGGNGYKREVARYRCEDCRGCPLREQCTKS--KKGRVLTIRPELNELLRQARERIKSEAGKALY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 995641728  114 SQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALNIRKIA 161
Cdd:pfam13751  78 RRRAITVEGTFAQIKRNLGLRRFRYRGLAKVTLQFLLTAAAHNLKKLH 125
IS5 COG3039
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
82-159 5.00e-04

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 39.85  E-value: 5.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995641728  82 KSNKKIMKNYNWEYF---KAQINQKLSEPETK--KIYSQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALN 156
Cdd:COG3039  226 AEKREELKARGIRWHiarKPGRNKPLSELQKRrnRRKAKVRAKVEHPFGVIKRLFGYKKVRYRGLAKNTAQLFLLAALYN 305


                 ...
gi 995641728 157 IRK 159
Cdd:COG3039  306 LKR 308
 
Name Accession Description Interval E-value
transpos_IS1182 NF033551
IS1182 family transposase; Members of this family are transposases of the IS1182 family. ...
 22-162 2.81e-38

IS1182 family transposase; Members of this family are transposases of the IS1182 family. About two-thirds of the members of this family have an extra domain between the middle and the C-terminal domain, about 50 amino acids in size and containing four invariant Cys residues.


Pssm-ID: 468080 [Multi-domain]  Cd Length: 437  Bit Score: 136.30  E-value: 2.81e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995641728  22 QNWKYDEFNDEFICPNNKRIGFKryayrnDRYGFKRDFKLYERDDCSACSLRHQCMKpnlKSNKKIMKNYNWEYFKAQIN 101
Cdd:NF033551 305 DDFRYDEEDDTYICPAGQRLTFK------TTSREGYREYRFDPEDCRGCPLREQCTK---SKEGRVVTRHIHEDLLEEAR 375

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 995641728 102 QKLSEPETKKIYSQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALNIRKIAA 162
Cdd:NF033551 376 ARLKTEEGKELYRKRKATVERVFAELKQWHGLRRFRLRGLEKVRAELLLTALAHNLKRLAA 436
DDE_Tnp_1_6 pfam13751
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
 34-161 9.64e-22

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.


Pssm-ID: 433453 [Multi-domain]  Cd Length: 125  Bit Score: 85.47  E-value: 9.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995641728   34 ICPNNKRIGFKrYAYRNDRYGFKRDFKLYERDDCSACSLRHQCMKPnlKSNKKIMKNYNWEYFKAQINQKLSEPETKKIY 113
Cdd:pfam13751   1 ICPAGKKLTLS-TTYREGGNGYKREVARYRCEDCRGCPLREQCTKS--KKGRVLTIRPELNELLRQARERIKSEAGKALY 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 995641728  114 SQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALNIRKIA 161
Cdd:pfam13751  78 RRRAITVEGTFAQIKRNLGLRRFRYRGLAKVTLQFLLTAAAHNLKKLH 125
DDE_Tnp_1 pfam01609
Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. ...
 93-156 1.46e-07

Transposase DDE domain; Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.


Pssm-ID: 376573 [Multi-domain]  Cd Length: 196  Bit Score: 49.55  E-value: 1.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 995641728   93 WEYFKAQINQKLSEPETKKIYSQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALN 156
Cdd:pfam01609 133 VDKLKGRVNSTLLSAETLAELYRRRWQIERVFKWLKRVFGLDRLRYRGLNAVEAELLLLALAYN 196
IS5 COG3039
Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];
82-159 5.00e-04

Transposase and inactivated derivatives, IS5 family [Mobilome: prophages, transposons];


Pssm-ID: 442273 [Multi-domain]  Cd Length: 316  Bit Score: 39.85  E-value: 5.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 995641728  82 KSNKKIMKNYNWEYF---KAQINQKLSEPETK--KIYSQRKIDVEPVFGFMKAILGFTRMSVRGINKVKRELGFVLMALN 156
Cdd:COG3039  226 AEKREELKARGIRWHiarKPGRNKPLSELQKRrnRRKAKVRAKVEHPFGVIKRLFGYKKVRYRGLAKNTAQLFLLAALYN 305


                 ...
gi 995641728 157 IRK 159
Cdd:COG3039  306 LKR 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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