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Conserved domains on  [gi|925779525|emb|CUG29093|]
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indole-3-glycerol phosphate synthase [Staphylococcus aureus]

Protein Classification

indole-3-glycerol phosphate synthase TrpC( domain architecture ID 10011355)

indole-3-glycerol-phosphate synthase (IGPS) TrpC is an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water

EC:  4.1.1.48
Gene Ontology:  GO:0004425|GO:0000162

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-257 4.87e-107

indole-3-glycerol phosphate synthase TrpC;


:

Pssm-ID: 234710  Cd Length: 260  Bit Score: 310.16  E-value: 4.87e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   1 MTILSEIVKYKQSLLQNGYYQDKLNTLKSVKIQNK--KSFINAIeKEPKLAIIAEIKSKSPTVNDL-PERDLSQQISDYD 77
Cdd:PRK00278   2 MDILDKIVAYKREEVAARKAQVPLAELKARAAAAPppRDFAAAL-RAGKPAVIAEVKKASPSKGVIrEDFDPVEIAKAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  78 QYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQN 157
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 158 LEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIG 237
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLAKAGADAVLVG 240

                        250       260
                 ....*....|....*....|
gi 925779525 238 EALMRCDNLSEFLPQLKMQK 257
Cdd:PRK00278 241 ESLMRADDPGAALRELLGAK 260
 
Name Accession Description Interval E-value
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-257 4.87e-107

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 310.16  E-value: 4.87e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   1 MTILSEIVKYKQSLLQNGYYQDKLNTLKSVKIQNK--KSFINAIeKEPKLAIIAEIKSKSPTVNDL-PERDLSQQISDYD 77
Cdd:PRK00278   2 MDILDKIVAYKREEVAARKAQVPLAELKARAAAAPppRDFAAAL-RAGKPAVIAEVKKASPSKGVIrEDFDPVEIAKAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  78 QYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQN 157
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 158 LEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIG 237
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLAKAGADAVLVG 240

                        250       260
                 ....*....|....*....|
gi 925779525 238 EALMRCDNLSEFLPQLKMQK 257
Cdd:PRK00278 241 ESLMRADDPGAALRELLGAK 260
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-253 1.68e-97

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 285.77  E-value: 1.68e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   2 TILSEIVKYKQSLLQNGYYQDKLNTLKSvKIQNKK---SFINAIEKEPKLAIIAEIKSKSPTVNDLPER-DLSQQISDYD 77
Cdd:COG0134    2 TILDKIVAHKREEVAARKARVPLAELEA-RAAAAPpprDFAAALRAAGGPAVIAEIKKASPSKGLIREDfDPAEIARAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  78 QYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQN 157
Cdd:COG0134   81 AGGAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 158 LEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIG 237
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLAAAGADAFLVG 240

                        250
                 ....*....|....*.
gi 925779525 238 EALMRCDNLSEFLPQL 253
Cdd:COG0134  241 EALMRAPDPGAALREL 256
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 38-253 4.91e-94

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 275.50  E-value: 4.91e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  38 FINAIEKEPKLAIIAEIKSKSPTVNDL-PERDLSQQISDYDQYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDF 116
Cdd:cd00331    1 FKAALKRPGGLGVIAEVKRASPSKGLIrEDFDPVEIAKAYEKAGAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 117 IIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVE 196
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 925779525 197 HTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIGEALMRCDNLSEFLPQL 253
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLAEAGADAVLIGESLMRAPDPGAALREL 217
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
4-250 4.28e-78

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 236.42  E-value: 4.28e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525    4 LSEIVKYKQSLLQNGYYQDKLNTLKSVKIQN-KKSFINAI-EKEPKLAIIAEIKSKSPTVNDL-PERDLSQQISDYDQYG 80
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAARAPpTRSFYDALrESRGRPALIAEVKKASPSKGLIrEDFDPAEIARVYEAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   81 ANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEV 160
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  161 LVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIGEAL 240
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKEHGANAFLVGESL 240

                         250
                  ....*....|
gi 925779525  241 MRCDNLSEFL 250
Cdd:pfam00218 241 MRQEDVRAAI 250
Indglycph_syn_Halo_TrpC NF041303
indole-3-glycerol phosphate synthase;
36-244 8.59e-43

indole-3-glycerol phosphate synthase;


Pssm-ID: 469200  Cd Length: 250  Bit Score: 145.89  E-value: 8.59e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  36 KSFINAI---EKEPKLAIIAEIKSKSPTVNDLPERD---LSQQISDYdqyGANAVSILTDEKYFGGSFERLQALTTKTTL 109
Cdd:NF041303  32 RSLPDAFaaaEADGRVPVIAEVKPTSPTTDGTRDDDpveLAEAMVAG---GAAALSVLTEPEHFGGSPETLRRVREAVDV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 110 PVLCKDFIIDPLQIDVAKqagASMILLIVNILSDkQLKDLYNYAISQNLEVLVEVHDRHELERAYKVNAKLIGVNNRDLK 189
Cdd:NF041303 109 PVLRKDFLLREAQLDAVE---ADVVLLIARFVGD-DLEGLVAAARERGFQPLVEVHTRAELERALDAGADIIGVNNRDLA 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 925779525 190 RFVTNVEHTNTIL----ENKKTnhyYISESGIHDASDVRKILHSGIDGLLIGEALMRCD 244
Cdd:NF041303 185 KLEVDLGTFESVAphvpDDDVT---LIAESGISTPADVRRMREAGADALLVGSAIMDGD 240
 
Name Accession Description Interval E-value
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-257 4.87e-107

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 310.16  E-value: 4.87e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   1 MTILSEIVKYKQSLLQNGYYQDKLNTLKSVKIQNK--KSFINAIeKEPKLAIIAEIKSKSPTVNDL-PERDLSQQISDYD 77
Cdd:PRK00278   2 MDILDKIVAYKREEVAARKAQVPLAELKARAAAAPppRDFAAAL-RAGKPAVIAEVKKASPSKGVIrEDFDPVEIAKAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  78 QYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQN 157
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 158 LEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIG 237
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLAKAGADAVLVG 240

                        250       260
                 ....*....|....*....|
gi 925779525 238 EALMRCDNLSEFLPQLKMQK 257
Cdd:PRK00278 241 ESLMRADDPGAALRELLGAK 260
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-253 1.68e-97

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 285.77  E-value: 1.68e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   2 TILSEIVKYKQSLLQNGYYQDKLNTLKSvKIQNKK---SFINAIEKEPKLAIIAEIKSKSPTVNDLPER-DLSQQISDYD 77
Cdd:COG0134    2 TILDKIVAHKREEVAARKARVPLAELEA-RAAAAPpprDFAAALRAAGGPAVIAEIKKASPSKGLIREDfDPAEIARAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  78 QYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQN 157
Cdd:COG0134   81 AGGAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 158 LEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIG 237
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLAAAGADAFLVG 240

                        250
                 ....*....|....*.
gi 925779525 238 EALMRCDNLSEFLPQL 253
Cdd:COG0134  241 EALMRAPDPGAALREL 256
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 38-253 4.91e-94

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 275.50  E-value: 4.91e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  38 FINAIEKEPKLAIIAEIKSKSPTVNDL-PERDLSQQISDYDQYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDF 116
Cdd:cd00331    1 FKAALKRPGGLGVIAEVKRASPSKGLIrEDFDPVEIAKAYEKAGAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 117 IIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVE 196
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 925779525 197 HTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIGEALMRCDNLSEFLPQL 253
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLAEAGADAVLIGESLMRAPDPGAALREL 217
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
4-250 4.28e-78

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 236.42  E-value: 4.28e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525    4 LSEIVKYKQSLLQNGYYQDKLNTLKSVKIQN-KKSFINAI-EKEPKLAIIAEIKSKSPTVNDL-PERDLSQQISDYDQYG 80
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAARAPpTRSFYDALrESRGRPALIAEVKKASPSKGLIrEDFDPAEIARVYEAAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   81 ANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEV 160
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  161 LVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKILHSGIDGLLIGEAL 240
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKEHGANAFLVGESL 240

                         250
                  ....*....|
gi 925779525  241 MRCDNLSEFL 250
Cdd:pfam00218 241 MRQEDVRAAI 250
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 2-246 5.08e-59

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 193.49  E-value: 5.08e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   2 TILSEIVKYKQSLLQNGYYQDKLNTLKSvKIQN-KKSFINAIeKEPKLAIIAEIKSKSPTV----NDLperDLSQQISDY 76
Cdd:PRK09427   5 TVLAKIVADKAIWVAARKQQQPLASFQN-EIQPsDRSFYDAL-KGPKTAFILECKKASPSKglirDDF---DPAEIARVY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  77 DQYgANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQ 156
Cdd:PRK09427  80 KHY-ASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 157 NLEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKiLHSGIDGLLI 236
Cdd:PRK09427 159 NMGVLTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRE-LSPFANGFLI 237

                        250
                 ....*....|
gi 925779525 237 GEALMRCDNL 246
Cdd:PRK09427 238 GSSLMAEDDL 247
Indglycph_syn_Halo_TrpC NF041303
indole-3-glycerol phosphate synthase;
36-244 8.59e-43

indole-3-glycerol phosphate synthase;


Pssm-ID: 469200  Cd Length: 250  Bit Score: 145.89  E-value: 8.59e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  36 KSFINAI---EKEPKLAIIAEIKSKSPTVNDLPERD---LSQQISDYdqyGANAVSILTDEKYFGGSFERLQALTTKTTL 109
Cdd:NF041303  32 RSLPDAFaaaEADGRVPVIAEVKPTSPTTDGTRDDDpveLAEAMVAG---GAAALSVLTEPEHFGGSPETLRRVREAVDV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 110 PVLCKDFIIDPLQIDVAKqagASMILLIVNILSDkQLKDLYNYAISQNLEVLVEVHDRHELERAYKVNAKLIGVNNRDLK 189
Cdd:NF041303 109 PVLRKDFLLREAQLDAVE---ADVVLLIARFVGD-DLEGLVAAARERGFQPLVEVHTRAELERALDAGADIIGVNNRDLA 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 925779525 190 RFVTNVEHTNTIL----ENKKTnhyYISESGIHDASDVRKILHSGIDGLLIGEALMRCD 244
Cdd:NF041303 185 KLEVDLGTFESVAphvpDDDVT---LIAESGISTPADVRRMREAGADALLVGSAIMDGD 240
PLN02460 PLN02460
indole-3-glycerol-phosphate synthase
 3-245 1.16e-42

indole-3-glycerol-phosphate synthase


Pssm-ID: 215254  Cd Length: 338  Bit Score: 148.00  E-value: 1.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   3 ILSEIVKYKQSLLQNGYYQDKLNTLKSVkIQN---KKSFINAIEKEPKL----AIIAEIKSKSPTVNDLPERDLSQQISD 75
Cdd:PLN02460  68 ILEEIVWYKDVEVAQMKERKPLYLLKKA-LQNappARDFVGALRAAHKRtgqpGLIAEVKKASPSRGVLRENFDPVEIAQ 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  76 -YDQYGANAVSILTDEKYFGGSFERLQAL-TTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYA 153
Cdd:PLN02460 147 aYEKGGAACLSVLTDEKYFQGSFENLEAIrNAGVKCPLLCKEFIVDAWQIYYARSKGADAILLIAAVLPDLDIKYMLKIC 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 154 ISQNLEVLVEVHDRHELERAYKVNA-KLIGVNNRDLKRFVTNVEHTNTILEN------KKTNHYYISESGIHDASDVRKI 226
Cdd:PLN02460 227 KSLGMAALIEVHDEREMDRVLGIEGvELIGINNRSLETFEVDISNTKKLLEGergeqiREKGIIVVGESGLFTPDDVAYV 306

                        250
                 ....*....|....*....
gi 925779525 227 LHSGIDGLLIGEALMRCDN 245
Cdd:PLN02460 307 QNAGVKAVLVGESLVKQDD 325
PRK13957 PRK13957
indole-3-glycerol-phosphate synthase; Provisional
 3-246 3.61e-41

indole-3-glycerol-phosphate synthase; Provisional


Pssm-ID: 140013  Cd Length: 247  Bit Score: 141.56  E-value: 3.61e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   3 ILSEIVKYKQSLLQNgyyQDKLNTLKSVKIQNKKSFinaieKEPKLAIIAEIKSKSPTVNDL-PERDLSQQISDYDQYGA 81
Cdd:PRK13957   4 VLREIIETKQNEIEK---ISRWDPLPDRGLPLRDSL-----KSRSFSIIAECKRKSPSAGELrADYHPVQIAKTYETLGA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  82 NAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVL 161
Cdd:PRK13957  76 SAISVLTDQSYFGGSLEDLKSVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPSQIKSFLKHASSLGMDVL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 162 VEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKiLHSGIDGLLIGEALM 241
Cdd:PRK13957 156 VEVHTEDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVAAFLPPNIVKVGESGIESRSDLDK-FRKLVDAALIGTYFM 234


                 ....*
gi 925779525 242 RCDNL 246
Cdd:PRK13957 235 EKKDI 239
PRK13802 PRK13802
bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional
 1-245 1.84e-39

bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 184335 [Multi-domain]  Cd Length: 695  Bit Score: 145.17  E-value: 1.84e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525   1 MTILSEIVKykqsllqnGYYQDKLNTLKSVKIQNKKSF-------INA---IEKEPKLAIIAEIKSKSPT---VNDLPer 67
Cdd:PRK13802   1 MSVLDELVA--------GALEDQRTRELTVSLEEVKKAaaaapapIDAtrwLKRADGIPVIAEIKRASPSkghLSDIP-- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  68 DLSQQISDYDQYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLK 147
Cdd:PRK13802  71 DPAALAREYEQGGASAISVLTEGRRFLGSLDDFDKVRAAVHIPVLRKDFIVTDYQIWEARAHGADLVLLIVAALDDAQLK 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 148 DLYNYAISQNLEVLVEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKTNHYYISESGIHDASDVRKIL 227
Cdd:PRK13802 151 HLLDLAHELGMTVLVETHTREEIERAIAAGAKVIGINARNLKDLKVDVNKYNELAADLPDDVIKVAESGVFGAVEVEDYA 230

                        250
                 ....*....|....*...
gi 925779525 228 HSGIDGLLIGEALMRCDN 245
Cdd:PRK13802 231 RAGADAVLVGEGVATADD 248
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
 65-237 9.89e-08

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 51.05  E-value: 9.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525  65 PERDLSQQISDYDQYGANAVSILTDEKYFGGSFERLQALTT----KTTLPVLCKDFIIDPLQI-----DVAKQAGASMIL 135
Cdd:cd04722   10 PSGDPVELAKAAAEAGADAIIVGTRSSDPEEAETDDKEVLKevaaETDLPLGVQLAINDAAAAvdiaaAAARAAGADGVE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925779525 136 LIVNILSD--------KQLKDLYNyaisqNLEVLVEVHDRHELERAYKVNAKLIGVN--NRD---LKRFVTNVEHTNTIL 202
Cdd:cd04722   90 IHGAVGYLaredleliRELREAVP-----DVKVVVKLSPTGELAAAAAEEAGVDEVGlgNGGgggGGRDAVPIADLLLIL 164

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 925779525 203 ENKKTNHYYISESGIHDASDVRKILHSGIDGLLIG 237
Cdd:cd04722  165 AKRGSKVPVIAGGGINDPEDAAEALALGADGVIVG 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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