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2-oxoglutarate dehydrogenase E1 component [Staphylococcus aureus]
Protein Classification
2-oxoglutarate dehydrogenase subunit E1 ( domain architecture ID 11484076 )
2-oxoglutarate dehydrogenase subunit E1 catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
1-929
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1389.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 1 M TNER K EVSEAPVN FGAN LGLMLD LY DDF L Q DP S SV P E DLQVL F STIKNDDSI V P ----------- A LKSTS S QNSDGTI 69
Cdd:PRK09404 1 M NSAM K AWLDSSFL FGAN AAYIEE LY EQY L K DP D SV D E EWRAF F DGLPGVAPD V A hsavresfrrl A KPARV S SAVSDPQ 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 70 KR V MR LI DNI R QY GHL K A DIY P VNPP KR KH VP K L EIEDFD L DQQT L EGISAGIVSDHFAD i YDNAY E A I LRME K R Y K G P I 149
Cdd:PRK09404 81 VK V LQ LI NAY R FR GHL A A NLD P LGLW KR PD VP E L DPAFYG L TEAD L DRTFNTGSLALGKE - TATLR E I I EALK K T Y C G S I 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 150 AF EY T HI NNNT ER G WL KR RIE TPYK v TLNNN EK R A LFKQ L AYV EGFE KY LH KN FVG A KRFS I EG VDA L V PML QRT I TI A A 229
Cdd:PRK09404 160 GV EY M HI SDPE ER R WL QQ RIE SGRP - SFSAE EK K A ILER L TAA EGFE RF LH TK FVG Q KRFS L EG GES L I PML DEI I RR A G 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 230 K E G I K N I Q IGMAHRGRLNVL TH VL E KP YEMMIS EF MH tdpm K FL P EDG slqlta GWT GDVKYHLG GIKTTDSY G TMQRIA 309
Cdd:PRK09404 239 K L G V K E I V IGMAHRGRLNVL VN VL G KP PRDLFA EF EG ---- K HG P DEV ------ LGS GDVKYHLG FSSDRETD G GEVHLS 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 310 LA N NPSHLEIV A PVVEG RT RA A QD DTQR agap TT D HH K AM PI I IHGDAA YP GQG INF ET M NL GN L K GY S TGG SL HI IT NN 389
Cdd:PRK09404 309 LA F NPSHLEIV N PVVEG SV RA R QD RRGD ---- GQ D RK K VL PI L IHGDAA FA GQG VVA ET L NL SQ L R GY R TGG TI HI VI NN 384
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 390 R IGFTT E P I D A RST T Y S TDVAK GYDV PIFHVN A DD V EA TIE A IDI A M E F R KE F H KDVVIDLV G YRR F GHNE M DEPS I T N P 469
Cdd:PRK09404 385 Q IGFTT S P P D D RST P Y C TDVAK MVQA PIFHVN G DD P EA VVF A TRL A L E Y R QK F K KDVVIDLV C YRR H GHNE G DEPS F T Q P 464
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 470 VP Y QN I R KH DSVEYVFGK KLV N EGVI S E D E MHSFIEQVQKE L RQAHDKINKADKM D NPDMEKPAD L ALPL - QADEQSFTF 548
Cdd:PRK09404 465 LM Y KK I K KH PTTRELYAD KLV A EGVI T E E E ADEMVNEYRDA L DAGFEVVKEWRPA D WLAGDWSPY L GHEW d DPVDTGVPL 544
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 549 DH LKE INDA L L T Y P D GF NILK K LN K V LE K R H E PFN k EDGLV DW AQ AE Q LAFA TI L QD G T P I RL T GQDS E RGTFSHRHAVL 628
Cdd:PRK09404 545 ER LKE LAEK L T T V P E GF KVHP K VK K I LE D R R E MAE - GEKPI DW GM AE A LAFA SL L DE G Y P V RL S GQDS G RGTFSHRHAVL 623
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 629 HD EQ TGETY T PL H H VPDQK A T F DIHN SPLSE A AV V GFEYGY NVENKKSFN IWEAQ Y GDFAN MS Q MIF D N F LF S SRS KWG E 708
Cdd:PRK09404 624 HD QK TGETY I PL N H LSEGQ A S F EVYD SPLSE E AV L GFEYGY STAEPNTLV IWEAQ F GDFAN GA Q VVI D Q F IS S GEQ KWG R 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 709 R SGL TLF LPH A YEGQGPEHSSARLERFLQL A AE N N CT V V N LSSSSN YFHLLR A QA A sld SEQMR PLVVM S PKSLLR NKTV 788
Cdd:PRK09404 704 L SGL VML LPH G YEGQGPEHSSARLERFLQL C AE D N MQ V C N PTTPAQ YFHLLR R QA L --- RPFRK PLVVM T PKSLLR HPLA 780
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 789 AKPID E FTS G G F E P ILTESYQA D -- KV TK V I L AT GK MFI DL K EA LA K NPDES V LL V A IE R LYPFP E EE IE A L LA QL PN LE 866
Cdd:PRK09404 781 VSSLE E LAE G S F Q P VIGDIDEL D pk KV KR V V L CS GK VYY DL L EA RR K RGIDD V AI V R IE Q LYPFP H EE LA A E LA KY PN AK 860
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 925923456 867 EV S W V QEEPKNQGAW LYVYPYVKVLVADKYD L S Y H GR IQR A A PA E G DGEI HK LV Q NKII E N AL 929
Cdd:PRK09404 861 EV V W C QEEPKNQGAW YFIQHHLEEVLPEGQK L R Y A GR PAS A S PA V G YMSL HK KQ Q EALV E D AL 923
Name
Accession
Description
Interval
E-value
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
1-929
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1389.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 1 M TNER K EVSEAPVN FGAN LGLMLD LY DDF L Q DP S SV P E DLQVL F STIKNDDSI V P ----------- A LKSTS S QNSDGTI 69
Cdd:PRK09404 1 M NSAM K AWLDSSFL FGAN AAYIEE LY EQY L K DP D SV D E EWRAF F DGLPGVAPD V A hsavresfrrl A KPARV S SAVSDPQ 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 70 KR V MR LI DNI R QY GHL K A DIY P VNPP KR KH VP K L EIEDFD L DQQT L EGISAGIVSDHFAD i YDNAY E A I LRME K R Y K G P I 149
Cdd:PRK09404 81 VK V LQ LI NAY R FR GHL A A NLD P LGLW KR PD VP E L DPAFYG L TEAD L DRTFNTGSLALGKE - TATLR E I I EALK K T Y C G S I 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 150 AF EY T HI NNNT ER G WL KR RIE TPYK v TLNNN EK R A LFKQ L AYV EGFE KY LH KN FVG A KRFS I EG VDA L V PML QRT I TI A A 229
Cdd:PRK09404 160 GV EY M HI SDPE ER R WL QQ RIE SGRP - SFSAE EK K A ILER L TAA EGFE RF LH TK FVG Q KRFS L EG GES L I PML DEI I RR A G 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 230 K E G I K N I Q IGMAHRGRLNVL TH VL E KP YEMMIS EF MH tdpm K FL P EDG slqlta GWT GDVKYHLG GIKTTDSY G TMQRIA 309
Cdd:PRK09404 239 K L G V K E I V IGMAHRGRLNVL VN VL G KP PRDLFA EF EG ---- K HG P DEV ------ LGS GDVKYHLG FSSDRETD G GEVHLS 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 310 LA N NPSHLEIV A PVVEG RT RA A QD DTQR agap TT D HH K AM PI I IHGDAA YP GQG INF ET M NL GN L K GY S TGG SL HI IT NN 389
Cdd:PRK09404 309 LA F NPSHLEIV N PVVEG SV RA R QD RRGD ---- GQ D RK K VL PI L IHGDAA FA GQG VVA ET L NL SQ L R GY R TGG TI HI VI NN 384
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 390 R IGFTT E P I D A RST T Y S TDVAK GYDV PIFHVN A DD V EA TIE A IDI A M E F R KE F H KDVVIDLV G YRR F GHNE M DEPS I T N P 469
Cdd:PRK09404 385 Q IGFTT S P P D D RST P Y C TDVAK MVQA PIFHVN G DD P EA VVF A TRL A L E Y R QK F K KDVVIDLV C YRR H GHNE G DEPS F T Q P 464
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 470 VP Y QN I R KH DSVEYVFGK KLV N EGVI S E D E MHSFIEQVQKE L RQAHDKINKADKM D NPDMEKPAD L ALPL - QADEQSFTF 548
Cdd:PRK09404 465 LM Y KK I K KH PTTRELYAD KLV A EGVI T E E E ADEMVNEYRDA L DAGFEVVKEWRPA D WLAGDWSPY L GHEW d DPVDTGVPL 544
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 549 DH LKE INDA L L T Y P D GF NILK K LN K V LE K R H E PFN k EDGLV DW AQ AE Q LAFA TI L QD G T P I RL T GQDS E RGTFSHRHAVL 628
Cdd:PRK09404 545 ER LKE LAEK L T T V P E GF KVHP K VK K I LE D R R E MAE - GEKPI DW GM AE A LAFA SL L DE G Y P V RL S GQDS G RGTFSHRHAVL 623
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 629 HD EQ TGETY T PL H H VPDQK A T F DIHN SPLSE A AV V GFEYGY NVENKKSFN IWEAQ Y GDFAN MS Q MIF D N F LF S SRS KWG E 708
Cdd:PRK09404 624 HD QK TGETY I PL N H LSEGQ A S F EVYD SPLSE E AV L GFEYGY STAEPNTLV IWEAQ F GDFAN GA Q VVI D Q F IS S GEQ KWG R 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 709 R SGL TLF LPH A YEGQGPEHSSARLERFLQL A AE N N CT V V N LSSSSN YFHLLR A QA A sld SEQMR PLVVM S PKSLLR NKTV 788
Cdd:PRK09404 704 L SGL VML LPH G YEGQGPEHSSARLERFLQL C AE D N MQ V C N PTTPAQ YFHLLR R QA L --- RPFRK PLVVM T PKSLLR HPLA 780
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 789 AKPID E FTS G G F E P ILTESYQA D -- KV TK V I L AT GK MFI DL K EA LA K NPDES V LL V A IE R LYPFP E EE IE A L LA QL PN LE 866
Cdd:PRK09404 781 VSSLE E LAE G S F Q P VIGDIDEL D pk KV KR V V L CS GK VYY DL L EA RR K RGIDD V AI V R IE Q LYPFP H EE LA A E LA KY PN AK 860
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 925923456 867 EV S W V QEEPKNQGAW LYVYPYVKVLVADKYD L S Y H GR IQR A A PA E G DGEI HK LV Q NKII E N AL 929
Cdd:PRK09404 861 EV V W C QEEPKNQGAW YFIQHHLEEVLPEGQK L R Y A GR PAS A S PA V G YMSL HK KQ Q EALV E D AL 923
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
15-930
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1130.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 15 F GAN LGLMLD LY DDF L Q DP S SV PEDLQVL F STIKNDDSIV ------------------ PALKSTSSQNSDGTI K -- RV MR 74
Cdd:COG0567 13 S GAN AAYIEE LY EQY L E DP D SV DPSWRAF F DGLPDVPGAR dfahspireefrklakng AGAAASAAADPEAAR K qv RV LQ 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 75 LI DNI R QY GHL K A DIY P VNPPK R KH VP K L EIEDFD L DQQT L E ----- G ISA G IVSDHFAD I YD nayeail RMEKR Y K G P I 149
Cdd:COG0567 93 LI NAY R VR GHL F A KLD P LGLRE R PY VP E L DPAFYG L TEAD L D tvfnt G SLL G LETATLRE I IA ------- ALKET Y C G S I 165
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 150 AF EY T HI NNNT E RG W LKR R I E TPY - KVTLNNN EK RALFKQ L AYV EGFEK Y LH KNF VG A KRFS I EG VDA L V P M L QRT I TI A 228
Cdd:COG0567 166 GV EY M HI SDPE E KR W IQE R L E STR n RPSFSAE EK KRILEK L TAA EGFEK F LH TKY VG Q KRFS L EG GES L I P A L DEL I ER A 245
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 229 AKE G I K N I Q IGMAHRGRLNVL THV L E KP YEMMI SEF mhtdpmkflp E DG S LQLTA G w T GDVKYHLG G --- IK T TD sy G TM 305
Cdd:COG0567 246 GEL G V K E I V IGMAHRGRLNVL VNI L G KP PRDIF SEF ---------- E GK S AEDVL G - S GDVKYHLG F ssd VE T PG -- G KV 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 306 q RIA LA N NPSHLEIV A PVVEG RT RA A QD dtq R A G ap T TD HH K AM PI I IHGDAA YP GQG INF ET M N LGN L K GY S TGG SL HI 385
Cdd:COG0567 313 - HLS LA F NPSHLEIV N PVVEG SV RA R QD --- R R G -- D TD RD K VL PI L IHGDAA FA GQG VVY ET L N MSQ L R GY R TGG TI HI 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 386 IT NN R IGFTT E P I DARS T TY S TDVAK GYDV PIFHVN A DD V EA TIEAIDI A MEF R KE F H KDVVIDLV G YRR F GHNE M DEP S 465
Cdd:COG0567 387 VI NN Q IGFTT S P R DARS S TY C TDVAK MVQA PIFHVN G DD P EA VVFVARL A LDY R QK F K KDVVIDLV C YRR H GHNE G DEP A 466
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 466 I T N P VP Y QN I R KH DSVEYVFGK KLV N EGVI SED E mhsf IEQVQK E L R Q A H D --------- K I NKAD KMD --------- NP 527
Cdd:COG0567 467 F T Q P LM Y KK I K KH PTTREIYAD KLV A EGVI TAE E ---- ADEMVD E Y R A A L D egfevvkey K P NKAD WLE gdwspyrrl GE 542
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 528 D MEK P A D LAL PL qadeqsftf DH LKE INDA L L T Y P D GF NILK K LN K V LE K R HEPFNK E DG L v DW AQ AE Q LA F A TI L QD G T 607
Cdd:COG0567 543 D WDD P V D TGV PL --------- EK LKE LGEK L T T L P E GF KLHP K VE K I LE D R RKMAEG E KP L - DW GM AE A LA Y A SL L DE G Y 612
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 608 P I RL T GQDS E RGTFSHRHAVLHD EQ TGETY T PL H H VPDQK A T F DIH NS P LSE A AV V GFEYGY NVENKKSFN IWEAQ Y GDF 687
Cdd:COG0567 613 P V RL S GQDS G RGTFSHRHAVLHD QK TGETY V PL N H LSEGQ A R F EVY NS L LSE E AV L GFEYGY ALAEPNTLV IWEAQ F GDF 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 688 AN MS Q MIF D N F LF S SR SKWG ER SGL TLF LPH A YEGQGPEHSSARLERFLQL A AE N N CT V V N LSSSSN YFHLLR A Q AAS ld 767
Cdd:COG0567 693 AN GA Q VVI D Q F IS S GE SKWG RL SGL VML LPH G YEGQGPEHSSARLERFLQL C AE D N MQ V C N PTTPAQ YFHLLR R Q MKR -- 770
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 768 se QM R - PL V VM S PKSLLR N K TVAKPID E FTS G G F EPILTESYQA D -- KV TK V I L AT GK MFI DL K E ALAKNPDES V LL V A I 844
Cdd:COG0567 771 -- PF R k PL I VM T PKSLLR H K LAVSSLE E LAE G S F QEVIDDTDEL D pk KV KR V V L CS GK VYY DL L E ERRERGRDD V AI V R I 848
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 845 E R LYPFPEEE IE A L LA QL PN LE EV S W V QEEPKN Q GAW LYVYPYVKVLVADKYD L S Y H GR IQR A A PA E G DGEI HK LV Q NKI 924
Cdd:COG0567 849 E Q LYPFPEEE LA A E LA KY PN AK EV V W C QEEPKN M GAW YFIQHRLEEVLPKGQR L R Y A GR PAS A S PA T G YMSV HK AE Q KAL 928
....*.
gi 925923456 925 I E N AL K 930
Cdd:COG0567 929 V E E AL G 934
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
16-929
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 960.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 16 GAN LGLMLD LY D D F L Q DP S SV PEDLQVL F STIKNDD siv PA LKSTS S Q ----------- N S D G T ----------- IKR V M 73
Cdd:TIGR00239 4 GAN QSYIEE LY E D Y L T DP D SV DASWRST F DQLPGPG --- PA PDQFH S P trsyfrrlakd A S R G S vtisdpdtnvs QVK V L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 74 R LI DNI R QY GHL K A DIY P VNPPKRKH VP K L EIEDFD L DQQT L E --- G I SAG i VS DHF A DIYDNAY E AILRMEKR Y K G P I A 150
Cdd:TIGR00239 81 Q LI RAY R FR GHL H A NLD P LGLKQQDK VP E L DLSFYG L TEAD L Q etf N I GSF - VS GKD A TMKLSNL E LLQALKQT Y C G S I G 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 151 F EY T HI NNNT E RG WL KR RIE TPYKVTL N NN EK RALFKQ L AYV EGFE KY L HKN F V GAKRFS I EG V DALVPML QRT I TIAAK 230
Cdd:TIGR00239 160 A EY M HI TSTE E KR WL QQ RIE SGERAQF N SE EK KRFLSR L TAA EGFE RF L GAK F P GAKRFS L EG L DALVPML KEI I RHSVN 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 231 E G IKNIQI GMAHRGRLNVL TH VL E KP Y E MMI SEF MHT d PMKF LP ED gslqltagw TGDVKYH L G GI --- K TTD sy G TMQR 307
Cdd:TIGR00239 240 S G TRDVVL GMAHRGRLNVL VN VL G KP P E DIF SEF AGK - HKSH LP DG --------- TGDVKYH M G RF ssd F TTD -- G KLVH 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 308 I ALA N NPSHLEIV A PVV E G R TRA AQ D dtqr AGAPTTDHH K AMP I I IHGDAA YP GQG INF ET M N LGN L K GYS T GG SL HII T 387
Cdd:TIGR00239 308 L ALA F NPSHLEIV S PVV I G S TRA RL D ---- RLNDSPEST K VLA I L IHGDAA FA GQG VVQ ET L N MSK L R GYS V GG TI HII I 383
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 388 NN R IGFTT E P I DARST T Y ST D V AK GYDV PIFHVNADD V EA TIE A IDI A M E F R KE F HK DV V IDLVGYRR F GHNE M DEPS I T 467
Cdd:TIGR00239 384 NN Q IGFTT N P L DARST P Y CS D L AK MIQA PIFHVNADD P EA VAF A TRL A V E Y R NT F KR DV F IDLVGYRR H GHNE A DEPS A T 463
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 468 N P VP YQ N I R KH DSVEY V FGK KLV N EGV IS E DEMHSFIEQVQKE L RQ A HDKINKADK M DNPDMEKPAD L ALPLQADEQS - F 546
Cdd:TIGR00239 464 Q P LM YQ K I K KH PTPRK V YAD KLV S EGV AT E EDVTEMVNLYRDA L EA A DCVVPSWRE M NTASFTWSPE L NHEWDEEYPN k V 543
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 547 TFDH L K E INDALLTY P D G FNILKKLN K VLEK R HEPFNKEDG L V DW AQ AE Q LAFAT ILQ DG T P I RL T G Q DSERGTF SH RHA 626
Cdd:TIGR00239 544 EMKR L Q E LAKRISEV P E G VEMHSRVA K IYFD R TKAMAAGEK L F DW GG AE N LAFAT LVD DG I P V RL S G E DSERGTF FQ RHA 623
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 627 VLHD EQT G E TYTPL H H VPDQKAT F DIH NS P LSE AA V V GFEYGY NVENKKSFN IWEAQ Y GDFAN MS Q MIF D N F LF S SRS KW 706
Cdd:TIGR00239 624 VLHD QSN G S TYTPL Q H LHNGQGA F RVW NS V LSE ES V L GFEYGY ATTSPRTLV IWEAQ F GDFAN GA Q VVI D Q F IS S GEQ KW 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 707 G ER SGL TLF LPH A YEGQGPEHSS A RLERFLQLAAE N N CT V VNLSSSSNY FH L LR A QA A sld SEQM RPLVVMSPKSLLR NK 786
Cdd:TIGR00239 704 G QM SGL VML LPH G YEGQGPEHSS G RLERFLQLAAE Q N MQ V CVPTTPAQV FH I LR R QA L --- RGMR RPLVVMSPKSLLR HP 780
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 787 TVAKPID E FTS G G F E P ILT E SYQA ------ DK V TKVI L AT GK MFI DL K E ALA KN PDES V LL V A IE R LYPFP EEEIEAL L A 860
Cdd:TIGR00239 781 LAVSSLE E LAE G T F Q P VIG E IEES glsldp EG V KRLV L CS GK VYY DL H E QRR KN GQKD V AI V R IE Q LYPFP HKAVKEV L Q 860
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 925923456 861 Q L PNL E E VS W V QEEP K N Q GAW L Y VY P YVKVLVADKYDLS Y H GR IQR A A PA E G DGEI H KLV Q NKIIEN AL 929
Cdd:TIGR00239 861 Q Y PNL K E IV W C QEEP L N M GAW Y Y SQ P HLREVIPEGVSVR Y A GR PAS A S PA V G YMSL H QKQ Q QDLLND AL 929
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
195-472
3.24e-134
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 402.68
E-value: 3.24e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 195 FE KY L HKN F V G A KRF SI EG VDA L V P M L QRT I TI AA KE G IKNIQ IGMAHRGRLNVL TH VL E KP Y E MMI SEF mhtdpmkflp 274
Cdd:cd02016 1 FE QF L ATK F P G Q KRF GL EG AES L I P A L DEL I DR AA EL G VEEVV IGMAHRGRLNVL AN VL G KP L E QIF SEF ---------- 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 275 e D G SLQLTAGW -- T GDVKYHLG GIKT -- T D S YGTM q RIA LA N NPSHLE I V A PVV E G R TRA A QD dtq RA G A pt TDHH K AM P 350
Cdd:cd02016 71 - E G KSEFPEDD eg S GDVKYHLG YSSD rk T P S GKKV - HLS LA P NPSHLE A V N PVV M G K TRA K QD --- YR G D -- GERD K VL P 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 351 I I IHGDAA YP GQG INF ET M NL G NL K GY S TGG SL HI IT NN R IGFTT E P I D A RS TT Y S TDVAK GYDV PIFHVN A DD V EA TIE 430
Cdd:cd02016 144 I L IHGDAA FA GQG VVY ET L NL S NL P GY T TGG TI HI VV NN Q IGFTT D P R D S RS SP Y C TDVAK MIGA PIFHVN G DD P EA VVR 223
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 925923456 431 A IDI A M E F R KE F H KDVVIDLV G YRR F GHNE M DEPS I T N P VP Y 472
Cdd:cd02016 224 A TRL A L E Y R QK F K KDVVIDLV C YRR H GHNE L DEPS F T Q P LM Y 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
212-527
3.75e-59
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 204.48
E-value: 3.75e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 212 EGVDA L VP M LQRTITIAAKE GI KNIQIGM A HRGRLN V LTHVLEK P YEMM I SEFMHT d PMKFLPEDGSLQLT A GWT G D V KY 291
Cdd:pfam00676 1 RRMMT L RR M EDARDALYKRQ GI RGFYHLY A GQEAAQ V GIAAALE P GDYI I PGYRDH - GNLLARGLSLEEIF A ELY G R V AK 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 292 HL GG IKTTDSYGTMQ R IALA N NPSHLEI va P VVE G RTR AA Q ddtqragapt TDHH K AMP I IIH GD A A y PG QG IN FE TM N L 371
Cdd:pfam00676 80 GK GG SMHGYYGAKGN R FYGG N GILGAQV -- P LGA G IAL AA K ---------- YRGK K EVA I TLY GD G A - AN QG DF FE GL N F 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 372 GN L KGYST ggs LHIIT NN RI G FT T EPID A RST T YST D V A K GY DV P IF HV NAD D VE A TIE A IDI A M E FRKEFHKDVV I D LV 451
Cdd:pfam00676 147 AA L WKLPV --- IFVCE NN QY G IS T PAER A SAS T TYA D R A R GY GI P GL HV DGM D PL A VYQ A SKF A A E RARTGKGPFL I E LV 223
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925923456 452 G YR RF GH NEM D E PS ITNPV - P Y QNI RK HDSVEYV F GKK LV NE GV I SE D E MHSFIEQ V Q KE LRQ A HD K I n KADKMDN P 527
Cdd:pfam00676 224 T YR YG GH SMS D D PS TYRTR d E Y EEV RK KKDPIQR F KEH LV SK GV W SE E E LKAIEKE V R KE VEE A FK K A - ESAPEPH P 299
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
654-784
1.18e-19
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 86.00
E-value: 1.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 654 NSPLS E A A V VGF EY G YNVENKK sfn IWEAQYGD F ANMSQMIFDNFL fssrs KW G ERSGLTLFLPHAYE G Q - GP E H S S ARL 732
Cdd:smart00861 19 DTGIA E Q A M VGF AA G LALHGLR --- PVVEIFFT F FDRAKDQIRSAG ----- AS G NVPVVFRHDGGGGV G E d GP T H H S IED 90
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 925923456 733 E - RFLQLA aen NCT VV NL S SSSNYFH LLRA QAASLD seqm RPLVVMSP KSL L R 784
Cdd:smart00861 91 E a LLRAIP --- GLK VV AP S DPAEAKG LLRA AIRDDG ---- PVVIRLER KSL Y R 136
Name
Accession
Description
Interval
E-value
sucA
PRK09404 2-oxoglutarate dehydrogenase E1 component; Reviewed
1-929
0e+00
2-oxoglutarate dehydrogenase E1 component; Reviewed
Pssm-ID: 236499 [Multi-domain]
Cd Length: 924
Bit Score: 1389.84
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 1 M TNER K EVSEAPVN FGAN LGLMLD LY DDF L Q DP S SV P E DLQVL F STIKNDDSI V P ----------- A LKSTS S QNSDGTI 69
Cdd:PRK09404 1 M NSAM K AWLDSSFL FGAN AAYIEE LY EQY L K DP D SV D E EWRAF F DGLPGVAPD V A hsavresfrrl A KPARV S SAVSDPQ 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 70 KR V MR LI DNI R QY GHL K A DIY P VNPP KR KH VP K L EIEDFD L DQQT L EGISAGIVSDHFAD i YDNAY E A I LRME K R Y K G P I 149
Cdd:PRK09404 81 VK V LQ LI NAY R FR GHL A A NLD P LGLW KR PD VP E L DPAFYG L TEAD L DRTFNTGSLALGKE - TATLR E I I EALK K T Y C G S I 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 150 AF EY T HI NNNT ER G WL KR RIE TPYK v TLNNN EK R A LFKQ L AYV EGFE KY LH KN FVG A KRFS I EG VDA L V PML QRT I TI A A 229
Cdd:PRK09404 160 GV EY M HI SDPE ER R WL QQ RIE SGRP - SFSAE EK K A ILER L TAA EGFE RF LH TK FVG Q KRFS L EG GES L I PML DEI I RR A G 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 230 K E G I K N I Q IGMAHRGRLNVL TH VL E KP YEMMIS EF MH tdpm K FL P EDG slqlta GWT GDVKYHLG GIKTTDSY G TMQRIA 309
Cdd:PRK09404 239 K L G V K E I V IGMAHRGRLNVL VN VL G KP PRDLFA EF EG ---- K HG P DEV ------ LGS GDVKYHLG FSSDRETD G GEVHLS 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 310 LA N NPSHLEIV A PVVEG RT RA A QD DTQR agap TT D HH K AM PI I IHGDAA YP GQG INF ET M NL GN L K GY S TGG SL HI IT NN 389
Cdd:PRK09404 309 LA F NPSHLEIV N PVVEG SV RA R QD RRGD ---- GQ D RK K VL PI L IHGDAA FA GQG VVA ET L NL SQ L R GY R TGG TI HI VI NN 384
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 390 R IGFTT E P I D A RST T Y S TDVAK GYDV PIFHVN A DD V EA TIE A IDI A M E F R KE F H KDVVIDLV G YRR F GHNE M DEPS I T N P 469
Cdd:PRK09404 385 Q IGFTT S P P D D RST P Y C TDVAK MVQA PIFHVN G DD P EA VVF A TRL A L E Y R QK F K KDVVIDLV C YRR H GHNE G DEPS F T Q P 464
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 470 VP Y QN I R KH DSVEYVFGK KLV N EGVI S E D E MHSFIEQVQKE L RQAHDKINKADKM D NPDMEKPAD L ALPL - QADEQSFTF 548
Cdd:PRK09404 465 LM Y KK I K KH PTTRELYAD KLV A EGVI T E E E ADEMVNEYRDA L DAGFEVVKEWRPA D WLAGDWSPY L GHEW d DPVDTGVPL 544
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 549 DH LKE INDA L L T Y P D GF NILK K LN K V LE K R H E PFN k EDGLV DW AQ AE Q LAFA TI L QD G T P I RL T GQDS E RGTFSHRHAVL 628
Cdd:PRK09404 545 ER LKE LAEK L T T V P E GF KVHP K VK K I LE D R R E MAE - GEKPI DW GM AE A LAFA SL L DE G Y P V RL S GQDS G RGTFSHRHAVL 623
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 629 HD EQ TGETY T PL H H VPDQK A T F DIHN SPLSE A AV V GFEYGY NVENKKSFN IWEAQ Y GDFAN MS Q MIF D N F LF S SRS KWG E 708
Cdd:PRK09404 624 HD QK TGETY I PL N H LSEGQ A S F EVYD SPLSE E AV L GFEYGY STAEPNTLV IWEAQ F GDFAN GA Q VVI D Q F IS S GEQ KWG R 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 709 R SGL TLF LPH A YEGQGPEHSSARLERFLQL A AE N N CT V V N LSSSSN YFHLLR A QA A sld SEQMR PLVVM S PKSLLR NKTV 788
Cdd:PRK09404 704 L SGL VML LPH G YEGQGPEHSSARLERFLQL C AE D N MQ V C N PTTPAQ YFHLLR R QA L --- RPFRK PLVVM T PKSLLR HPLA 780
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 789 AKPID E FTS G G F E P ILTESYQA D -- KV TK V I L AT GK MFI DL K EA LA K NPDES V LL V A IE R LYPFP E EE IE A L LA QL PN LE 866
Cdd:PRK09404 781 VSSLE E LAE G S F Q P VIGDIDEL D pk KV KR V V L CS GK VYY DL L EA RR K RGIDD V AI V R IE Q LYPFP H EE LA A E LA KY PN AK 860
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 925923456 867 EV S W V QEEPKNQGAW LYVYPYVKVLVADKYD L S Y H GR IQR A A PA E G DGEI HK LV Q NKII E N AL 929
Cdd:PRK09404 861 EV V W C QEEPKNQGAW YFIQHHLEEVLPEGQK L R Y A GR PAS A S PA V G YMSL HK KQ Q EALV E D AL 923
SucA
COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes ...
15-930
0e+00
2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440333 [Multi-domain]
Cd Length: 935
Bit Score: 1130.17
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 15 F GAN LGLMLD LY DDF L Q DP S SV PEDLQVL F STIKNDDSIV ------------------ PALKSTSSQNSDGTI K -- RV MR 74
Cdd:COG0567 13 S GAN AAYIEE LY EQY L E DP D SV DPSWRAF F DGLPDVPGAR dfahspireefrklakng AGAAASAAADPEAAR K qv RV LQ 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 75 LI DNI R QY GHL K A DIY P VNPPK R KH VP K L EIEDFD L DQQT L E ----- G ISA G IVSDHFAD I YD nayeail RMEKR Y K G P I 149
Cdd:COG0567 93 LI NAY R VR GHL F A KLD P LGLRE R PY VP E L DPAFYG L TEAD L D tvfnt G SLL G LETATLRE I IA ------- ALKET Y C G S I 165
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 150 AF EY T HI NNNT E RG W LKR R I E TPY - KVTLNNN EK RALFKQ L AYV EGFEK Y LH KNF VG A KRFS I EG VDA L V P M L QRT I TI A 228
Cdd:COG0567 166 GV EY M HI SDPE E KR W IQE R L E STR n RPSFSAE EK KRILEK L TAA EGFEK F LH TKY VG Q KRFS L EG GES L I P A L DEL I ER A 245
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 229 AKE G I K N I Q IGMAHRGRLNVL THV L E KP YEMMI SEF mhtdpmkflp E DG S LQLTA G w T GDVKYHLG G --- IK T TD sy G TM 305
Cdd:COG0567 246 GEL G V K E I V IGMAHRGRLNVL VNI L G KP PRDIF SEF ---------- E GK S AEDVL G - S GDVKYHLG F ssd VE T PG -- G KV 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 306 q RIA LA N NPSHLEIV A PVVEG RT RA A QD dtq R A G ap T TD HH K AM PI I IHGDAA YP GQG INF ET M N LGN L K GY S TGG SL HI 385
Cdd:COG0567 313 - HLS LA F NPSHLEIV N PVVEG SV RA R QD --- R R G -- D TD RD K VL PI L IHGDAA FA GQG VVY ET L N MSQ L R GY R TGG TI HI 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 386 IT NN R IGFTT E P I DARS T TY S TDVAK GYDV PIFHVN A DD V EA TIEAIDI A MEF R KE F H KDVVIDLV G YRR F GHNE M DEP S 465
Cdd:COG0567 387 VI NN Q IGFTT S P R DARS S TY C TDVAK MVQA PIFHVN G DD P EA VVFVARL A LDY R QK F K KDVVIDLV C YRR H GHNE G DEP A 466
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 466 I T N P VP Y QN I R KH DSVEYVFGK KLV N EGVI SED E mhsf IEQVQK E L R Q A H D --------- K I NKAD KMD --------- NP 527
Cdd:COG0567 467 F T Q P LM Y KK I K KH PTTREIYAD KLV A EGVI TAE E ---- ADEMVD E Y R A A L D egfevvkey K P NKAD WLE gdwspyrrl GE 542
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 528 D MEK P A D LAL PL qadeqsftf DH LKE INDA L L T Y P D GF NILK K LN K V LE K R HEPFNK E DG L v DW AQ AE Q LA F A TI L QD G T 607
Cdd:COG0567 543 D WDD P V D TGV PL --------- EK LKE LGEK L T T L P E GF KLHP K VE K I LE D R RKMAEG E KP L - DW GM AE A LA Y A SL L DE G Y 612
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 608 P I RL T GQDS E RGTFSHRHAVLHD EQ TGETY T PL H H VPDQK A T F DIH NS P LSE A AV V GFEYGY NVENKKSFN IWEAQ Y GDF 687
Cdd:COG0567 613 P V RL S GQDS G RGTFSHRHAVLHD QK TGETY V PL N H LSEGQ A R F EVY NS L LSE E AV L GFEYGY ALAEPNTLV IWEAQ F GDF 692
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 688 AN MS Q MIF D N F LF S SR SKWG ER SGL TLF LPH A YEGQGPEHSSARLERFLQL A AE N N CT V V N LSSSSN YFHLLR A Q AAS ld 767
Cdd:COG0567 693 AN GA Q VVI D Q F IS S GE SKWG RL SGL VML LPH G YEGQGPEHSSARLERFLQL C AE D N MQ V C N PTTPAQ YFHLLR R Q MKR -- 770
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 768 se QM R - PL V VM S PKSLLR N K TVAKPID E FTS G G F EPILTESYQA D -- KV TK V I L AT GK MFI DL K E ALAKNPDES V LL V A I 844
Cdd:COG0567 771 -- PF R k PL I VM T PKSLLR H K LAVSSLE E LAE G S F QEVIDDTDEL D pk KV KR V V L CS GK VYY DL L E ERRERGRDD V AI V R I 848
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 845 E R LYPFPEEE IE A L LA QL PN LE EV S W V QEEPKN Q GAW LYVYPYVKVLVADKYD L S Y H GR IQR A A PA E G DGEI HK LV Q NKI 924
Cdd:COG0567 849 E Q LYPFPEEE LA A E LA KY PN AK EV V W C QEEPKN M GAW YFIQHRLEEVLPKGQR L R Y A GR PAS A S PA T G YMSV HK AE Q KAL 928
....*.
gi 925923456 925 I E N AL K 930
Cdd:COG0567 929 V E E AL G 934
2oxo_dh_E1
TIGR00239 2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists ...
16-929
0e+00
2-oxoglutarate dehydrogenase, E1 component; The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase. [Energy metabolism, TCA cycle]
Pssm-ID: 161785 [Multi-domain]
Cd Length: 929
Bit Score: 960.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 16 GAN LGLMLD LY D D F L Q DP S SV PEDLQVL F STIKNDD siv PA LKSTS S Q ----------- N S D G T ----------- IKR V M 73
Cdd:TIGR00239 4 GAN QSYIEE LY E D Y L T DP D SV DASWRST F DQLPGPG --- PA PDQFH S P trsyfrrlakd A S R G S vtisdpdtnvs QVK V L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 74 R LI DNI R QY GHL K A DIY P VNPPKRKH VP K L EIEDFD L DQQT L E --- G I SAG i VS DHF A DIYDNAY E AILRMEKR Y K G P I A 150
Cdd:TIGR00239 81 Q LI RAY R FR GHL H A NLD P LGLKQQDK VP E L DLSFYG L TEAD L Q etf N I GSF - VS GKD A TMKLSNL E LLQALKQT Y C G S I G 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 151 F EY T HI NNNT E RG WL KR RIE TPYKVTL N NN EK RALFKQ L AYV EGFE KY L HKN F V GAKRFS I EG V DALVPML QRT I TIAAK 230
Cdd:TIGR00239 160 A EY M HI TSTE E KR WL QQ RIE SGERAQF N SE EK KRFLSR L TAA EGFE RF L GAK F P GAKRFS L EG L DALVPML KEI I RHSVN 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 231 E G IKNIQI GMAHRGRLNVL TH VL E KP Y E MMI SEF MHT d PMKF LP ED gslqltagw TGDVKYH L G GI --- K TTD sy G TMQR 307
Cdd:TIGR00239 240 S G TRDVVL GMAHRGRLNVL VN VL G KP P E DIF SEF AGK - HKSH LP DG --------- TGDVKYH M G RF ssd F TTD -- G KLVH 307
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 308 I ALA N NPSHLEIV A PVV E G R TRA AQ D dtqr AGAPTTDHH K AMP I I IHGDAA YP GQG INF ET M N LGN L K GYS T GG SL HII T 387
Cdd:TIGR00239 308 L ALA F NPSHLEIV S PVV I G S TRA RL D ---- RLNDSPEST K VLA I L IHGDAA FA GQG VVQ ET L N MSK L R GYS V GG TI HII I 383
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 388 NN R IGFTT E P I DARST T Y ST D V AK GYDV PIFHVNADD V EA TIE A IDI A M E F R KE F HK DV V IDLVGYRR F GHNE M DEPS I T 467
Cdd:TIGR00239 384 NN Q IGFTT N P L DARST P Y CS D L AK MIQA PIFHVNADD P EA VAF A TRL A V E Y R NT F KR DV F IDLVGYRR H GHNE A DEPS A T 463
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 468 N P VP YQ N I R KH DSVEY V FGK KLV N EGV IS E DEMHSFIEQVQKE L RQ A HDKINKADK M DNPDMEKPAD L ALPLQADEQS - F 546
Cdd:TIGR00239 464 Q P LM YQ K I K KH PTPRK V YAD KLV S EGV AT E EDVTEMVNLYRDA L EA A DCVVPSWRE M NTASFTWSPE L NHEWDEEYPN k V 543
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 547 TFDH L K E INDALLTY P D G FNILKKLN K VLEK R HEPFNKEDG L V DW AQ AE Q LAFAT ILQ DG T P I RL T G Q DSERGTF SH RHA 626
Cdd:TIGR00239 544 EMKR L Q E LAKRISEV P E G VEMHSRVA K IYFD R TKAMAAGEK L F DW GG AE N LAFAT LVD DG I P V RL S G E DSERGTF FQ RHA 623
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 627 VLHD EQT G E TYTPL H H VPDQKAT F DIH NS P LSE AA V V GFEYGY NVENKKSFN IWEAQ Y GDFAN MS Q MIF D N F LF S SRS KW 706
Cdd:TIGR00239 624 VLHD QSN G S TYTPL Q H LHNGQGA F RVW NS V LSE ES V L GFEYGY ATTSPRTLV IWEAQ F GDFAN GA Q VVI D Q F IS S GEQ KW 703
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 707 G ER SGL TLF LPH A YEGQGPEHSS A RLERFLQLAAE N N CT V VNLSSSSNY FH L LR A QA A sld SEQM RPLVVMSPKSLLR NK 786
Cdd:TIGR00239 704 G QM SGL VML LPH G YEGQGPEHSS G RLERFLQLAAE Q N MQ V CVPTTPAQV FH I LR R QA L --- RGMR RPLVVMSPKSLLR HP 780
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 787 TVAKPID E FTS G G F E P ILT E SYQA ------ DK V TKVI L AT GK MFI DL K E ALA KN PDES V LL V A IE R LYPFP EEEIEAL L A 860
Cdd:TIGR00239 781 LAVSSLE E LAE G T F Q P VIG E IEES glsldp EG V KRLV L CS GK VYY DL H E QRR KN GQKD V AI V R IE Q LYPFP HKAVKEV L Q 860
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 925923456 861 Q L PNL E E VS W V QEEP K N Q GAW L Y VY P YVKVLVADKYDLS Y H GR IQR A A PA E G DGEI H KLV Q NKIIEN AL 929
Cdd:TIGR00239 861 Q Y PNL K E IV W C QEEP L N M GAW Y Y SQ P HLREVIPEGVSVR Y A GR PAS A S PA V G YMSL H QKQ Q QDLLND AL 929
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
71-929
0e+00
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 958.96
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 71 RVM R LI DNI R QY GHL K AD IY P VNPPK R K H v P K L EIED ----- F DLD QQTLE G ISA G IVSDHFA DI YD nayea I LR me KR Y 145
Cdd:PRK12270 388 RVM E LI HAY R VR GHL M AD TD P LEYRQ R S H - P D L DVLT hgltl W DLD REFPV G GFG G KERMKLR DI LG ----- V LR -- DS Y 459
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 146 KGPIAF EY T HI NNNTE R G WL KR R I E T P YK v TLNNN E KRALFKQ L AYV E G FE KY L HKNF VG A KRFS I EG VDA L V P M L QRTI 225
Cdd:PRK12270 460 CRTVGI EY M HI QDPEQ R R WL QE R V E R P HE - KPTRE E QKRILSK L NAA E A FE TF L QTKY VG Q KRFS L EG GES L I P L L DAVL 538
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 226 TI AA KE G IKNIQ IGMAHRGRLNVL THVLE KPY EMMIS EF M - HT DP M kflpedgslql T A GWT GDVKYHLG -- G IK T TDS y 302
Cdd:PRK12270 539 DQ AA EH G LDEVV IGMAHRGRLNVL ANIVG KPY SQIFR EF E g NL DP R ----------- S A QGS GDVKYHLG ae G TF T QMF - 606
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 303 G TMQRIA LA N NPSHLE I V A PV V EG RT RA A QD DTQRAGA pttd HHKAM PI II HGDAA YP GQG INF ET M NL GN L K GY S TGG S 382
Cdd:PRK12270 607 G DEIKVS LA A NPSHLE A V D PV L EG IV RA K QD RLDKGEE ---- GFTVL PI LL HGDAA FA GQG VVA ET L NL SQ L R GY R TGG T 682
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 383 L HI IT NN RI GFTT E P IDA RS TT Y S TDVAK GYDV PIFHVN A DD V EA TIEAIDI A M E F R KE FHKDVVIDLV G YRR F GHNE M D 462
Cdd:PRK12270 683 I HI VV NN QV GFTT A P ESS RS SE Y A TDVAK MIQA PIFHVN G DD P EA VVRVARL A F E Y R QR FHKDVVIDLV C YRR R GHNE G D 762
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 463 E PS I T N P VP Y QN I RKHD SV EYVFGKK L VNE G V I SED E MHSFIEQV Q KE L RQAHDKINK A D K MDNPDM E KPADLAL P LQAD 542
Cdd:PRK12270 763 D PS M T Q P LM Y DL I DAKR SV RKLYTEA L IGR G D I TVE E AEQALRDY Q GQ L ERVFNEVRE A E K KPPEPP E SVESDQG P PAGV 842
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 543 EQSFTFDH L KE I N DA LLTY P D GF NILK KL NKV LEKR H E PF nk ED G LV DWA QA E Q LAF ATI L QD GTP I RL T GQDS E RGTFS 622
Cdd:PRK12270 843 DTAVSAEV L ER I G DA HVNL P E GF TVHP KL KPL LEKR R E MA -- RE G GI DWA FG E L LAF GSL L LE GTP V RL S GQDS R RGTFS 920
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 623 H RHAVL H D EQ TGE T YTPL HHVP D QKAT F DIHN S P LSE A A VV GFEYGY N VE NKKSFNI WEAQ Y GDFAN MS Q M I F D N F LF S S 702
Cdd:PRK12270 921 Q RHAVL I D RE TGE E YTPL QNLS D DQGK F LVYD S L LSE Y A AM GFEYGY S VE RPDALVL WEAQ F GDFAN GA Q T I I D E F IS S G 1000
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 703 RS KWG E RSG LT L F LPH A YEGQGP E HSSAR L ERFLQL A AE N N C TV VNL S SSS NYFHLLR A QA as L DSEQ m RPLVV MS PKS L 782
Cdd:PRK12270 1001 EA KWG Q RSG VV L L LPH G YEGQGP D HSSAR I ERFLQL C AE G N M TV AQP S TPA NYFHLLR R QA -- L SGPR - RPLVV FT PKS M 1077
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 783 LR N K TVAKPIDE FT S G G F E P ILTESYQA D -- KV TK V I L AT GK MFI DL KEALA K NPDESVLL V AI E R LYP F P EE E IEAL LA 860
Cdd:PRK12270 1078 LR L K AAVSDVED FT E G K F R P VIDDPTVD D ga KV RR V L L CS GK LYY DL AARRE K DGRDDTAI V RV E Q LYP L P RA E LREA LA 1157
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 925923456 861 QL PN LE EV S WVQEEP K NQGAW LYVYPYVKV L VA D KYD L SYHG R IQR A A PA E G DGEI H KLV Q NKIIEN A L 929
Cdd:PRK12270 1158 RY PN AT EV V WVQEEP A NQGAW PFMALNLPE L LP D GRR L RRVS R PAS A S PA T G SAKV H AVE Q QELLDE A F 1226
TPP_E1_OGDC_like
cd02016 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed ...
195-472
3.24e-134
Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of the tricarboxylic acid cycle.
Pssm-ID: 238974 [Multi-domain]
Cd Length: 265
Bit Score: 402.68
E-value: 3.24e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 195 FE KY L HKN F V G A KRF SI EG VDA L V P M L QRT I TI AA KE G IKNIQ IGMAHRGRLNVL TH VL E KP Y E MMI SEF mhtdpmkflp 274
Cdd:cd02016 1 FE QF L ATK F P G Q KRF GL EG AES L I P A L DEL I DR AA EL G VEEVV IGMAHRGRLNVL AN VL G KP L E QIF SEF ---------- 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 275 e D G SLQLTAGW -- T GDVKYHLG GIKT -- T D S YGTM q RIA LA N NPSHLE I V A PVV E G R TRA A QD dtq RA G A pt TDHH K AM P 350
Cdd:cd02016 71 - E G KSEFPEDD eg S GDVKYHLG YSSD rk T P S GKKV - HLS LA P NPSHLE A V N PVV M G K TRA K QD --- YR G D -- GERD K VL P 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 351 I I IHGDAA YP GQG INF ET M NL G NL K GY S TGG SL HI IT NN R IGFTT E P I D A RS TT Y S TDVAK GYDV PIFHVN A DD V EA TIE 430
Cdd:cd02016 144 I L IHGDAA FA GQG VVY ET L NL S NL P GY T TGG TI HI VV NN Q IGFTT D P R D S RS SP Y C TDVAK MIGA PIFHVN G DD P EA VVR 223
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 925923456 431 A IDI A M E F R KE F H KDVVIDLV G YRR F GHNE M DEPS I T N P VP Y 472
Cdd:cd02016 224 A TRL A L E Y R QK F K KDVVIDLV C YRR H GHNE L DEPS F T Q P LM Y 265
E1_dh
pfam00676 Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family ...
212-527
3.75e-59
Dehydrogenase E1 component; This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.
Pssm-ID: 395548 [Multi-domain]
Cd Length: 300
Bit Score: 204.48
E-value: 3.75e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 212 EGVDA L VP M LQRTITIAAKE GI KNIQIGM A HRGRLN V LTHVLEK P YEMM I SEFMHT d PMKFLPEDGSLQLT A GWT G D V KY 291
Cdd:pfam00676 1 RRMMT L RR M EDARDALYKRQ GI RGFYHLY A GQEAAQ V GIAAALE P GDYI I PGYRDH - GNLLARGLSLEEIF A ELY G R V AK 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 292 HL GG IKTTDSYGTMQ R IALA N NPSHLEI va P VVE G RTR AA Q ddtqragapt TDHH K AMP I IIH GD A A y PG QG IN FE TM N L 371
Cdd:pfam00676 80 GK GG SMHGYYGAKGN R FYGG N GILGAQV -- P LGA G IAL AA K ---------- YRGK K EVA I TLY GD G A - AN QG DF FE GL N F 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 372 GN L KGYST ggs LHIIT NN RI G FT T EPID A RST T YST D V A K GY DV P IF HV NAD D VE A TIE A IDI A M E FRKEFHKDVV I D LV 451
Cdd:pfam00676 147 AA L WKLPV --- IFVCE NN QY G IS T PAER A SAS T TYA D R A R GY GI P GL HV DGM D PL A VYQ A SKF A A E RARTGKGPFL I E LV 223
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925923456 452 G YR RF GH NEM D E PS ITNPV - P Y QNI RK HDSVEYV F GKK LV NE GV I SE D E MHSFIEQ V Q KE LRQ A HD K I n KADKMDN P 527
Cdd:pfam00676 224 T YR YG GH SMS D D PS TYRTR d E Y EEV RK KKDPIQR F KEH LV SK GV W SE E E LKAIEKE V R KE VEE A FK K A - ESAPEPH P 299
Transket_pyr
pfam02779 Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate ...
589-784
1.60e-44
Transketolase, pyrimidine binding domain; This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.
Pssm-ID: 460692 [Multi-domain]
Cd Length: 174
Bit Score: 158.48
E-value: 1.60e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 589 VDWAQ A EQL A F A TILQDGTPIRLT G Q D SER GTF SHRHAV LH DEQT G E tytplhhvpdqkatfd IHNSPLS E A A V VGF EY G 668
Cdd:pfam02779 3 IATRK A SGE A L A ELAKRDPRVVGG G A D LAG GTF TVTKGL LH PQGA G R ---------------- VIDTGIA E Q A M VGF AN G 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 669 YNVENKK s FNIW EA QYG DF A N msqm IF D NFLFSSRSKWGERSG - LTLFL P HAYEGQ GP E H S S ARLER FL QLAA en NCT VV 747
Cdd:pfam02779 67 MALHGPL - LPPV EA TFS DF L N ---- RA D DAIRHGAALGKLPVP f VVTRD P IGVGED GP T H Q S VEDLA FL RAIP -- GLK VV 139
170 180 190
....*....|....*....|....*....|....*..
gi 925923456 748 NL S SSSNYFH LLRA QAASLDS eqm R P L V VMS P KS LLR 784
Cdd:pfam02779 140 RP S DAAETKG LLRA AIRRDGR --- K P V V LRL P RQ LLR 173
OxoGdeHyase_C
pfam16870 2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately ...
791-929
8.65e-37
2-oxoglutarate dehydrogenase C-terminal; OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, pfam02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase.
Pssm-ID: 465289 [Multi-domain]
Cd Length: 147
Bit Score: 135.26
E-value: 8.65e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 791 PID EFT S G G - F EPILTESY --- QAD KV TK V I L AT GK MFI DL - KE ALAKNPDES V LL V A IE R LYPFP EEEIEAL L AQL PN L 865
Cdd:pfam16870 3 SLE EFT P G T h F QRVIPDPE plv DPE KV KR V V L CS GK VYY DL l KE REERGGIKD V AI V R IE Q LYPFP FDLLKEE L DKY PN A 82
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 925923456 866 E E VS W V QEEPKNQGAW LY V Y P YV - K VL VADKYD L S Y H GR IQR A A PA E G DGEI H KLV Q NKIIEN A L 929
Cdd:pfam16870 83 A E IV W C QEEPKNQGAW SF V Q P RL e T VL NETGHR L R Y A GR PPS A S PA T G SKSV H LAE Q EALLDD A F 147
Transket_pyr
smart00861 Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer ...
654-784
1.18e-19
Transketolase, pyrimidine binding domain; Transketolase (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways. TK requires thiamine pyrophosphate as a cofactor. In most sources where TK has been purified, it is a homodimer of approximately 70 Kd subunits. TK sequences from a variety of eukaryotic and prokaryotic sources show that the enzyme has been evolutionarily conserved. In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
Pssm-ID: 214865 [Multi-domain]
Cd Length: 136
Bit Score: 86.00
E-value: 1.18e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 654 NSPLS E A A V VGF EY G YNVENKK sfn IWEAQYGD F ANMSQMIFDNFL fssrs KW G ERSGLTLFLPHAYE G Q - GP E H S S ARL 732
Cdd:smart00861 19 DTGIA E Q A M VGF AA G LALHGLR --- PVVEIFFT F FDRAKDQIRSAG ----- AS G NVPVVFRHDGGGGV G E d GP T H H S IED 90
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 925923456 733 E - RFLQLA aen NCT VV NL S SSSNYFH LLRA QAASLD seqm RPLVVMSP KSL L R 784
Cdd:smart00861 91 E a LLRAIP --- GLK VV AP S DPAEAKG LLRA AIRDDG ---- PVVIRLER KSL Y R 136
TPP_E1_PDC_ADC_BCADC
cd02000 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; ...
355-514
6.67e-09
Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).
Pssm-ID: 238958 [Multi-domain]
Cd Length: 293
Bit Score: 58.28
E-value: 6.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 355 GD A A Y p GQ G INF E TM N LG nlkgystgg S L H ------ IIT NN RIGFT T e P IDA rs T T YS T DV A K --- G Y DV P IFH V NAD DV 425
Cdd:cd02000 134 GD G A T - NE G DFH E AL N FA --------- A L W klpvif VCE NN GYAIS T - P TSR -- Q T AG T SI A D raa A Y GI P GIR V DGN DV 200
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925923456 426 ---- EA TI EA IDI A mef R KE f HKDVV I DL V G YR RF GH NEM D E PS I tnpvp Y ------ QNIR K H D SVE y VFG K K L VNE G VI 495
Cdd:cd02000 201 lavy EA AK EA VER A --- R AG - GGPTL I EA V T YR LG GH STS D D PS R ----- Y rtkeev EEWK K R D PIL - RLR K Y L IEA G IL 270
170
....*....|....*....
gi 925923456 496 S E D E MHSFIEQ V QK E LRQ A 514
Cdd:cd02000 271 T E E E LAAIEAE V KA E VEE A 289
2-oxogl_dehyd_N
pfam16078 2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of ...
15-50
1.51e-03
2-oxoglutarate dehydrogenase N-terminus; This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases.
Pssm-ID: 465008 [Multi-domain]
Cd Length: 41
Bit Score: 37.13
E-value: 1.51e-03
10 20 30
....*....|....*....|....*....|....*.
gi 925923456 15 F GAN LGLMLD LY DDF L Q DPSSV PEDLQVL F STIKND 50
Cdd:pfam16078 5 S GAN AAYIEE LY EQY L K DPSSV DPSWRAY F DNLDDG 40
Frr
COG0233 Ribosome recycling factor [Translation, ribosomal structure and biogenesis];
474-524
4.39e-03
Ribosome recycling factor [Translation, ribosomal structure and biogenesis];
Pssm-ID: 440003
Cd Length: 185
Bit Score: 39.25
E-value: 4.39e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 925923456 474 NIR KH -- D SV eyvfg KKL VNEGV ISEDE MHSFIEQV QK elrq AH DK - I N K A D KM 524
Cdd:COG0233 130 NIR RD an D DL ----- KKL EKDKE ISEDE LKRAEDEI QK ---- LT DK y I K K I D EL 174
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
14-63
5.54e-03
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 40.64
E-value: 5.54e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 925923456 14 N FG A N LG L MLDL Y DDF L Q DP S SV PEDLQVL F STIKNDDSIV P ALKSTSSQ 63
Cdd:PRK12270 3 E FG Q N EW L VEEM Y QQY L A DP N SV DPSWREF F ADYGPGSTAA P TAAAAAAA 52
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
