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Conserved domains on  [gi|925762059|emb|CUC82901|]
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Ubiquinone/menaquinone biosynthesis methyltransferase UbiE/ COQ5 [Staphylococcus aureus]

Protein Classification

class I SAM-dependent DNA methyltransferase( domain architecture ID 11471966)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047
PubMed:  23180741|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
4-135 2.06e-30

Predicted methyltransferase, contains TPR repeat [General function prediction only];


:

Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 111.24  E-value: 2.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   4 YAEMSLVYDQ-LTQDQPYEKWFEIVKNHCKD-----ESNILDIGCGTGSLTVQLEALG-NVTGMDLSVDMLTVAAQKSAN 76
Cdd:COG4976   11 FDQYADSYDAaLVEDLGYEAPALLAEELLARlppgpFGRVLDLGCGTGLLGEALRPRGyRLTGVDLSEEMLAKAREKGVY 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  77 VNWLEGDMTSFD-LQQQFDIItIFCDSLNYLQDetaVIETFINVYHHLTDSGVFIFDVHT 135
Cdd:COG4976   91 DRLLVADLADLAePDGRFDLI-VAADVLTYLGD---LAAVFAGVARALKPGGLFIFSVED 146
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
4-135 2.06e-30

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 111.24  E-value: 2.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   4 YAEMSLVYDQ-LTQDQPYEKWFEIVKNHCKD-----ESNILDIGCGTGSLTVQLEALG-NVTGMDLSVDMLTVAAQKSAN 76
Cdd:COG4976   11 FDQYADSYDAaLVEDLGYEAPALLAEELLARlppgpFGRVLDLGCGTGLLGEALRPRGyRLTGVDLSEEMLAKAREKGVY 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  77 VNWLEGDMTSFD-LQQQFDIItIFCDSLNYLQDetaVIETFINVYHHLTDSGVFIFDVHT 135
Cdd:COG4976   91 DRLLVADLADLAePDGRFDLI-VAADVLTYLGD---LAAVFAGVARALKPGGLFIFSVED 146
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 37-127 9.13e-17

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 72.98  E-value: 9.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   37 ILDIGCGTGSLTVQLEALGN--VTGMDLSVDMLTVAAQKSA----NVNWLEGDMTSFDLQ-QQFDIITIFCdSLNYLQDE 109
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGarVTGVDLSPEMLERARERAAeaglNVEFVQGDAEDLPFPdGSFDLVVSSG-VLHHLPDP 79

                          90
                  ....*....|....*...
gi 925762059  110 tAVIETFINVYHHLTDSG 127
Cdd:pfam13649  80 -DLEAALREIARVLKPGG 96
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 35-98 3.40e-11

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 60.94  E-value: 3.40e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 925762059  35 SNILDIGCGTGSLTVQLE----ALGNVTGMDLSVDMLTVAAQK------SANVNWLEGDMTS--FDlQQQFDIITI 98
Cdd:PRK00216  53 DKVLDLACGTGDLAIALAkavgKTGEVVGLDFSEGMLAVGREKlrdlglSGNVEFVQGDAEAlpFP-DNSFDAVTI 127
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 36-136 5.94e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.13  E-value: 5.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  36 NILDIGCGTGSLTVQLEALG--NVTGMDLSVDMLTVAAQKSA-----NVNWLEGDMTSFDLQ--QQFDIItIFCDSLNYL 106
Cdd:cd02440    1 RVLDLGCGTGALALALASGPgaRVTGVDISPVALELARKAAAalladNVEVLKGDAEELPPEadESFDVI-ISDPPLHHL 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 925762059 107 QDETAviETFINVYHHLTDSGVFIFDVHTV 136
Cdd:cd02440   80 VEDLA--RFLEEARRLLKPGGVLVLTLVLA 107
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 37-131 1.67e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 53.44  E-value: 1.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   37 ILDIGCGTGSLTVQLEALGN---VTGMDLSVDMLTVAAQK-SANVNWLEGDMTSFDLQ-QQFDIItIFCDSLNYLQDETA 111
Cdd:TIGR02072  38 VLDIGCGTGYLTRALLKRFPqaeFIALDISAGMLAQAKTKlSENVQFICGDAEKLPLEdSSFDLI-VSNLALQWCDDLSQ 116

                          90       100
                  ....*....|....*....|
gi 925762059  112 VIEtfiNVYHHLTDSGVFIF 131
Cdd:TIGR02072 117 ALS---ELARVLKPGGLLAF 133
rADc smart00650
Ribosomal RNA adenine dimethylases;
36-96 3.49e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 37.11  E-value: 3.49e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 925762059    36 NILDIGCGTGSLTVQL-EALGNVTGMDLSVDM---LTVAAQKSANVNWLEGDMTSFDL-QQQFDII 96
Cdd:smart00650  16 TVLEIGPGKGALTEELlERAKRVTAIEIDPRLaprLREKFAAADNLTVIHGDALKFDLpKLQPYKV 81
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
4-135 2.06e-30

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 111.24  E-value: 2.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   4 YAEMSLVYDQ-LTQDQPYEKWFEIVKNHCKD-----ESNILDIGCGTGSLTVQLEALG-NVTGMDLSVDMLTVAAQKSAN 76
Cdd:COG4976   11 FDQYADSYDAaLVEDLGYEAPALLAEELLARlppgpFGRVLDLGCGTGLLGEALRPRGyRLTGVDLSEEMLAKAREKGVY 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  77 VNWLEGDMTSFD-LQQQFDIItIFCDSLNYLQDetaVIETFINVYHHLTDSGVFIFDVHT 135
Cdd:COG4976   91 DRLLVADLADLAePDGRFDLI-VAADVLTYLGD---LAAVFAGVARALKPGGLFIFSVED 146
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
35-133 1.04e-23

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 91.04  E-value: 1.04e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  35 SNILDIGCGTGSLTVQLEAL---GNVTGMDLSVDMLTVAAQKSANVNWLEGDMTSFDLQQQFDIItIFCDSLNYLQDETA 111
Cdd:COG4106    3 RRVLDLGCGTGRLTALLAERfpgARVTGVDLSPEMLARARARLPNVRFVVADLRDLDPPEPFDLV-VSNAALHWLPDHAA 81

                         90       100
                 ....*....|....*....|..
gi 925762059 112 VIEtfiNVYHHLTDSGVFIFDV 133
Cdd:COG4106   82 LLA---RLAAALAPGGVLAVQV 100
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 15-133 2.78e-22

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 88.15  E-value: 2.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  15 TQDQPYEKW----FEIVKNHCKDESNILDIGCGTGSLTVQLEALG-NVTGMDLSVDMLTVAAQKSA--NVNWLEGDMTSF 87
Cdd:COG2227    2 SDPDARDFWdrrlAALLARLLPAGGRVLDVGCGTGRLALALARRGaDVTGVDISPEALEIARERAAelNVDFVQGDLEDL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 925762059  88 DLQ-QQFDIItIFCDSLNYLQDETAVIEtfiNVYHHLTDSGVFIFDV 133
Cdd:COG2227   82 PLEdGSFDLV-ICSEVLEHLPDPAALLR---ELARLLKPGGLLLLST 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 20-135 2.47e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 75.80  E-value: 2.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  20 YEKWFEIVKN-HCKDESNILDIGCGTGSLTVQL-EALGNVTGMDLSVDMLTVAAQKSA----NVNWLEGDMTSFDLQ-QQ 92
Cdd:COG2226    8 YDGREALLAAlGLRPGARVLDLGCGTGRLALALaERGARVTGVDISPEMLELARERAAeaglNVEFVVGDAEDLPFPdGS 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 925762059  93 FDIITIFCdSLNYLQDETAVIEtfiNVYHHLTDSGVFIFDVHT 135
Cdd:COG2226   88 FDLVISSF-VLHHLPDPERALA---EIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 37-127 9.13e-17

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 72.98  E-value: 9.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   37 ILDIGCGTGSLTVQLEALGN--VTGMDLSVDMLTVAAQKSA----NVNWLEGDMTSFDLQ-QQFDIITIFCdSLNYLQDE 109
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGarVTGVDLSPEMLERARERAAeaglNVEFVQGDAEDLPFPdGSFDLVVSSG-VLHHLPDP 79

                          90
                  ....*....|....*...
gi 925762059  110 tAVIETFINVYHHLTDSG 127
Cdd:pfam13649  80 -DLEAALREIARVLKPGG 96
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 18-183 8.33e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 67.63  E-value: 8.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  18 QPYEKWFEIVKNHCKDESNILDIGCGTGSLTVQLEALGN--VTGMDLSVDMLTVA-----AQKSANVNWLEGDMTSFD-- 88
Cdd:COG0500   11 LPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGgrVIGIDLSPEAIALAraraaKAGLGNVEFLVADLAELDpl 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  89 LQQQFDIItIFCDSLNYLQDETAViETFINVYHHLTDSGVFIFdVHTVYKMMtLFNNQSYIDDKGDIFLAWDAVQGDLPL 168
Cdd:COG0500   91 PAESFDLV-VAFGVLHHLPPEERE-ALLRELARALKPGGVLLL-SASDAAAA-LSLARLLLLATASLLELLLLLRLLALE 166

                        170
                 ....*....|....*
gi 925762059 169 SVYHDMTFFIRHEDE 183
Cdd:COG0500  167 LYLRALLAAAATEDL 181
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 38-129 1.92e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 61.61  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   38 LDIGCGTGSLTVQLEAL---GNVTGMDLSVDMLTVAAQK--------SANVNWLEGDMTSFDLqQQFDIITIfCDSLNYL 106
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpgLEYTGLDISPAALEAARERlaalgllnAVRVELFQLDLGELDP-GSFDVVVA-SNVLHHL 78

                          90       100
                  ....*....|....*....|...
gi 925762059  107 QDETAVIEtfiNVYHHLTDSGVF 129
Cdd:pfam08242  79 ADPRAVLR---NIRRLLKPGGVL 98
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 38-131 9.01e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 59.60  E-value: 9.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   38 LDIGCGTGSLTVQLEALG-NVTGMDLSVDMLTVAAQKS--ANVNWLEGDMTSFDLQ-QQFDIITIFcDSLNYLQD-ETAV 112
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGaRVTGVDISPEMLELAREKAprEGLTFVVGDAEDLPFPdNSFDLVLSS-EVLHHVEDpERAL 79

                          90
                  ....*....|....*....
gi 925762059  113 IEtfinVYHHLTDSGVFIF 131
Cdd:pfam08241  80 RE----IARVLKPGGILII 94
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 35-98 3.40e-11

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 60.94  E-value: 3.40e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 925762059  35 SNILDIGCGTGSLTVQLE----ALGNVTGMDLSVDMLTVAAQK------SANVNWLEGDMTS--FDlQQQFDIITI 98
Cdd:PRK00216  53 DKVLDLACGTGDLAIALAkavgKTGEVVGLDFSEGMLAVGREKlrdlglSGNVEFVQGDAEAlpFP-DNSFDAVTI 127
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 37-131 9.74e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 58.40  E-value: 9.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  37 ILDIGCGTGSLTVQL-EALG-NVTGMDLSVDMLTVAAQK------SANVNWLEGDMTSFDLQQQFDIItIFCDSLNYLQD 108
Cdd:COG2230   55 VLDIGCGWGGLALYLaRRYGvRVTGVTLSPEQLEYARERaaeaglADRVEVRLADYRDLPADGQFDAI-VSIGMFEHVGP 133

                         90       100
                 ....*....|....*....|...
gi 925762059 109 EtAVIETFINVYHHLTDSGVFIF 131
Cdd:COG2230  134 E-NYPAYFAKVARLLKPGGRLLL 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 36-136 5.94e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.13  E-value: 5.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  36 NILDIGCGTGSLTVQLEALG--NVTGMDLSVDMLTVAAQKSA-----NVNWLEGDMTSFDLQ--QQFDIItIFCDSLNYL 106
Cdd:cd02440    1 RVLDLGCGTGALALALASGPgaRVTGVDISPVALELARKAAAalladNVEVLKGDAEELPPEadESFDVI-ISDPPLHHL 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 925762059 107 QDETAviETFINVYHHLTDSGVFIFDVHTV 136
Cdd:cd02440   80 VEDLA--RFLEEARRLLKPGGVLVLTLVLA 107
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 32-130 4.44e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 53.57  E-value: 4.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   32 KDESNILDIGCGTGSLTVQLEAL----GNVTGMDLSVDMLTVAAQ-----KSANVNWLEGDMTSFDLQ---QQFDIITIF 99
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEElgpnAEVVGIDISEEAIEKAREnaqklGFDNVEFEQGDIEELPELledDKFDVVISN 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 925762059  100 CdSLNYLQDETAVIETFINVyhhLTDSGVFI 130
Cdd:pfam13847  82 C-VLNHIPDPDKVLQEILRV---LKPGGRLI 108
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 37-131 1.67e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 53.44  E-value: 1.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   37 ILDIGCGTGSLTVQLEALGN---VTGMDLSVDMLTVAAQK-SANVNWLEGDMTSFDLQ-QQFDIItIFCDSLNYLQDETA 111
Cdd:TIGR02072  38 VLDIGCGTGYLTRALLKRFPqaeFIALDISAGMLAQAKTKlSENVQFICGDAEKLPLEdSSFDLI-VSNLALQWCDDLSQ 116

                          90       100
                  ....*....|....*....|
gi 925762059  112 VIEtfiNVYHHLTDSGVFIF 131
Cdd:TIGR02072 117 ALS---ELARVLKPGGLLAF 133
NodS pfam05401
Nodulation protein S (NodS); This family consists of nodulation S (NodS) proteins. The ...
 32-131 2.66e-07

Nodulation protein S (NodS); This family consists of nodulation S (NodS) proteins. The products of the rhizobial nodulation genes are involved in the biosynthesis of lipochitin oligosaccharides (LCOs), which are host-specific signal molecules required for nodule formation. NodS is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase involved in N methylation of LCOs. NodS uses N-deacetylated chitooligosaccharides, the products of the NodBC proteins, as its methyl acceptors.


Pssm-ID: 428457  Cd Length: 201  Bit Score: 49.62  E-value: 2.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   32 KDESNILDIGCGTGSLTVQL----EALGNVTGMDLSVDMLTVAAQKSANVNWLEGDMTSFDLQQQFDIItIFCDSLNYLQ 107
Cdd:pfam05401  42 GDAADALEIGCAAGAFTEMLailcERLTVVDLMPEAIAKAQERTGKWSDIIWHECDICQFDLNAKFDLI-ICAEVLYYIH 120

                          90       100
                  ....*....|....*....|....
gi 925762059  108 DETAVIETFINVYHHLTDSGVFIF 131
Cdd:pfam05401 121 DKEELHAAIENIVQLLAPDEQFIF 144
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 37-112 1.00e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 47.91  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  37 ILDIGCGTGSLTVQLEALG-NVTGMDLSVDMLTVAAQK------SANVNWLEGDMTSfdLQQQFDiiTIFC-DSLNYLQD 108
Cdd:PRK07580  67 ILDAGCGVGSLSIPLARRGaKVVASDISPQMVEEARERapeaglAGNITFEVGDLES--LLGRFD--TVVClDVLIHYPQ 142


                 ....
gi 925762059 109 ETAV 112
Cdd:PRK07580 143 EDAA 146
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 31-136 1.66e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 46.65  E-value: 1.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   31 CKDESNILDIGCGTGSLTVQLEALG-NVTGMDLSVDMLTVAAQKSANVNwlEGDMTSFDLQQQFDIITIFcDSLNYLQDE 109
Cdd:pfam13489  20 LPSPGRVLDFGCGTGIFLRLLRAQGfSVTGVDPSPIAIERALLNVRFDQ--FDEQEAAVPAGKFDVIVAR-EVLEHVPDP 96

                          90       100
                  ....*....|....*....|....*..
gi 925762059  110 TAVIETFINvyhHLTDSGVFIFDVHTV 136
Cdd:pfam13489  97 PALLRQIAA---LLKPGGLLLLSTPLA 120
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 32-96 3.04e-06

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 47.08  E-value: 3.04e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 925762059  32 KDESNILDIGCGTG--SLTVQLEALG-NVTGMDLSVDMLTVAAQ-----KSANVNWLEGDMTSFDLQQQFDII 96
Cdd:PRK09328 107 KEPLRVLDLGTGSGaiALALAKERPDaEVTAVDISPEALAVARRnakhgLGARVEFLQGDWFEPLPGGRFDLI 179
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
33-96 3.82e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 46.05  E-value: 3.82e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  33 DESNILDIGCGTGSLTVQLEALG--NVTGMDLSVDMLTVAAQK----SANVNWLEGDMTSFDLQQQFDII 96
Cdd:COG2263   45 EGKTVLDLGCGTGMLAIGAALLGakKVVGVDIDPEALEIARENaerlGVRVDFIRADVTRIPLGGSVDTV 114
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 36-96 6.36e-06

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 45.91  E-value: 6.36e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 925762059  36 NILDIGCGTG--SLTVQLEALG-NVTGMDLSVDMLTVA---AQK---SANVNWLEGDMTS-FDLQQQFDII 96
Cdd:COG2890  115 RVLDLGTGSGaiALALAKERPDaRVTAVDISPDALAVArrnAERlglEDRVRFLQGDLFEpLPGDGRFDLI 185
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 37-103 3.56e-05

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 43.59  E-value: 3.56e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 925762059  37 ILDIGCGTGSLTVQLEALG-NVTGMDLSVDMLTVAAQKSANVNWLEGDMTSFDLQQ-QFDII-----TIFCDSL 103
Cdd:PRK10258  46 VLDAGCGPGWMSRYWRERGsQVTALDLSPPMLAQARQKDAADHYLAGDIESLPLATaTFDLAwsnlaVQWCGNL 119
PRK08317 PRK08317
hypothetical protein; Provisional
 37-108 8.02e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 42.62  E-value: 8.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  37 ILDIGCGTGSLTVQLEAL----GNVTGMDLSVDMLTVAAQKSA----NVNWLEGDMTSFDLQQQ-FDIITIfCDSLNYLQ 107
Cdd:PRK08317  23 VLDVGCGPGNDARELARRvgpeGRVVGIDRSEAMLALAKERAAglgpNVEFVRGDADGLPFPDGsFDAVRS-DRVLQHLE 101


                 .
gi 925762059 108 D 108
Cdd:PRK08317 102 D 102
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 26-97 1.72e-04

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 41.96  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059   26 IVKNHCKDEsnILDIGCGTGSLTVQLeALGN----VTGMDLSVDMLTVA---AQK---SANVNWLEGDMTSFDLQQQFDI 95
Cdd:TIGR00536 109 LISQPPILH--ILDLGTGSGCIALAL-AYEFpnaeVIAVDISPDALAVAeenAEKnqlEHRVEFIQSNLFEPLAGQKIDI 185


                  ..
gi 925762059   96 IT 97
Cdd:TIGR00536 186 IV 187
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
35-98 1.93e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 41.27  E-value: 1.93e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 925762059   35 SNILDIGCGTGSLTVQL----EALGNVTGMDLSVDMLTVAAQKS-----ANVNWLEGDMTSFDLQQ-QFDIITI 98
Cdd:pfam01209  44 NKFLDVAGGTGDWTFGLsdsaGSSGKVVGLDINENMLKEGEKKAkeegkYNIEFLQGNAEELPFEDdSFDIVTI 117
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 35-96 5.94e-04

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 39.93  E-value: 5.94e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 925762059  35 SNILDIGCGTGS---LTVQLEALGNVTGMDLSVDMLTVAAQKSANVNWLEGDMTSFDLQQQFDII 96
Cdd:PRK01683  33 RYVVDLGCGPGNsteLLVERWPAARITGIDSSPAMLAEARSRLPDCQFVEADIASWQPPQALDLI 97
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 36-116 9.83e-04

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 39.49  E-value: 9.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  36 NILDIGCGTGSLTVQLE----ALGNVTGMDLSVDMLTVAAQKS--------ANVNWLEGDMTSFDLQQ-QFDIITIFCDS 102
Cdd:PLN02233  76 RVLDLCCGSGDLAFLLSekvgSDGKVMGLDFSSEQLAVAASRQelkakscyKNIEWIEGDATDLPFDDcYFDAITMGYGL 155

                         90
                 ....*....|....
gi 925762059 103 LNYLQDETAVIETF 116
Cdd:PLN02233 156 RNVVDRLKAMQEMY 169
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
23-130 1.80e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 38.48  E-value: 1.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  23 WFEIVKNHCKDESNILDIGCGTGSLT---VQLEAlGNVTGMDLSVDMLTVAAQKSA------NVNWLEGDMTSFDLQQQF 93
Cdd:COG4076   25 FKAAIERVVKPGDVVLDIGTGSGLLSmlaARAGA-KKVYAVEVNPDIAAVARRIIAanglsdRITVINADATDLDLPEKA 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 925762059  94 DIitIFCDSL-NYLQDE--TAVIETFINVYhhLTDSGVFI 130
Cdd:COG4076  104 DV--IISEMLdTALLDEgqVPILNHARKRL--LKPGGRII 139
rADc smart00650
Ribosomal RNA adenine dimethylases;
36-96 3.49e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 37.11  E-value: 3.49e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 925762059    36 NILDIGCGTGSLTVQL-EALGNVTGMDLSVDM---LTVAAQKSANVNWLEGDMTSFDL-QQQFDII 96
Cdd:smart00650  16 TVLEIGPGKGALTEELlERAKRVTAIEIDPRLaprLREKFAAADNLTVIHGDALKFDLpKLQPYKV 81
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
36-119 4.02e-03

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 37.64  E-value: 4.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  36 NILDIGCGTGSLTVQLEALG-NVTGMDLSVDMLTVAAQkSANVNWLEGDMT---------SFDLQQQFDIItIFCDSLNY 105
Cdd:PRK11036  47 RVLDAGGGEGQTAIKLAELGhQVILCDLSAEMIQRAKQ-AAEAKGVSDNMQfihcaaqdiAQHLETPVDLI-LFHAVLEW 124

                         90
                 ....*....|....
gi 925762059 106 LQDETAVIETFINV 119
Cdd:PRK11036 125 VADPKSVLQTLWSV 138
MetW pfam07021
Methionine biosynthesis protein MetW; This family consists of several bacterial and one ...
 24-84 4.82e-03

Methionine biosynthesis protein MetW; This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalyzed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganizms the reaction is catalyzed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells.


Pssm-ID: 399779  Cd Length: 193  Bit Score: 37.05  E-value: 4.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 925762059   24 FEIVKNHCKDESNILDIGCGTGSLTVQLEALGNVTGMDLSVDMLTVAAQKSANVNWLEGDM 84
Cdd:pfam07021   4 FRYILEWIPPGSRVLDLGCGDGTLLYLLKEEKGVDGYGIELDAAGVAECVAKGLYVIQGDL 64
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 37-131 4.82e-03

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 37.24  E-value: 4.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925762059  37 ILDIGCGTGS----LTVQLEALGNVTGMDLSVDMLTVA---AQKSAN-----VNWLEGDMTSFDLQQQFDIITiFCDSLN 104
Cdd:COG5459   84 VLDVGAGPGTaawaAADAWPSLLDATLLERSAAALALGrrlARAAANpaletAEWRLADLAAALPAPPADLVV-ASYVLN 162

                         90       100
                 ....*....|....*....|....*....
gi 925762059 105 YLQDE--TAVIETFinvyhHLTDSGVFIF 131
Cdd:COG5459  163 ELADAarAALVDRL-----WLAPDGALLI 186
PRK12335 PRK12335
tellurite resistance protein TehB; Provisional
 35-96 7.18e-03

tellurite resistance protein TehB; Provisional


Pssm-ID: 183450 [Multi-domain]  Cd Length: 287  Bit Score: 36.84  E-value: 7.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925762059  35 SNILDIGCGTGSLTVQLEALG-NVTGMD---LSVDMLTVAAQK-SANVNWLEGDMTSFDLQQQFDII 96
Cdd:PRK12335 122 GKALDLGCGQGRNSLYLALLGfDVTAVDinqQSLENLQEIAEKeNLNIRTGLYDINSASIQEEYDFI 188
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 32-94 7.58e-03

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 36.64  E-value: 7.58e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925762059  32 KDESNILDIGCGTGSLTVQL-EALGNVTGMDL---SVDMLTVAAQKSANVNWLEGDMTSFDLQQQFD 94
Cdd:COG0030   36 TPGDTVLEIGPGLGALTRALlERAARVTAVEIdrrLAAILRETFAAYPNLTVIEGDALKVDLPALAA 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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