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Conserved domains on  [gi|805023975|emb|CRC84818|]
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ATPase [Mycobacterium tuberculosis]

Protein Classification

CDC48 family AAA ATPase( domain architecture ID 1001098)

CDC48 family AAA ATPase is involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus; similar to yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC48 super family cl36852
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 22-688 8.47e-125

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


The actual alignment was detected with superfamily member TIGR01243:

Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 388.88  E-value: 8.47e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975   22 DSRRGVVRLHPNAIAALGIREWDAVSLTGSR--TTAAVAGLAAADTAVGTVLLDDVTLSNAGLREGTEVIVSPVTVYGAR 99
Cdd:TIGR01243  13 DVGRGIVRIDRQTAARLGVEPGDFVEIEKGDrsVVAIVWPLRPDDEGRGIIRMDGYLRANAGVTIGDTVTVERAEVKEAK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  100 SVTLSGST-LATQSVPPVTLRQALLGKVMTVGDAVsllprdlgpgtstsaasralaaAVGISWTSELLTVTGVDPDGPVS 178
Cdd:TIGR01243  93 KVVLAPTQpIRFGRDFVDYVKEFLLGKPISKGETV----------------------IVPVLEGALPFVVVSTQPAGFVY 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  179 VQPNSLVTWgagVPAAMGTSTAGQVsissPEIQIEELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGV 258
Cdd:TIGR01243 151 VTEATEVEI---REKPVREEIERKV----PKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGT 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  259 GKATLVRAVCD--GRRLVTLDGPEIGALAAGD---RVKAVASavQAVRHEGGVLLITDADALLPAAAEPVASL---ILSE 330
Cdd:TIGR01243 224 GKTLLAKAVANeaGAYFISINGPEIMSKYYGEseeRLREIFK--EAEENAPSIIFIDEIDAIAPKREEVTGEVekrVVAQ 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  331 LRTAV----ATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTG-DLNLDEIASRTPGFV 405
Cdd:TIGR01243 302 LLTLMdglkGRGRVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMPLAeDVDLDKLAEVTHGFV 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  406 VADLAALVREAALRAASRASADGRPPM--------------LHQDDLLGALTVIRPlsrSASDE--VTVGDVTLDDVGDM 469
Cdd:TIGR01243 382 GADLAALAKEAAMAALRRFIREGKINFeaeeipaevlkelkVTMKDFMEALKMVEP---SAIREvlVEVPNVRWSDIGGL 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  470 AAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVREL 549
Cdd:TIGR01243 459 EEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREI 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  550 FRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVF 629
Cdd:TIGR01243 539 FRKARQAAPAIIFFDEIDAIAPARGARFDTSVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLIL 618

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975  630 VEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSI 688
Cdd:TIGR01243 619 VPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESI 677
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 22-688 8.47e-125

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 388.88  E-value: 8.47e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975   22 DSRRGVVRLHPNAIAALGIREWDAVSLTGSR--TTAAVAGLAAADTAVGTVLLDDVTLSNAGLREGTEVIVSPVTVYGAR 99
Cdd:TIGR01243  13 DVGRGIVRIDRQTAARLGVEPGDFVEIEKGDrsVVAIVWPLRPDDEGRGIIRMDGYLRANAGVTIGDTVTVERAEVKEAK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  100 SVTLSGST-LATQSVPPVTLRQALLGKVMTVGDAVsllprdlgpgtstsaasralaaAVGISWTSELLTVTGVDPDGPVS 178
Cdd:TIGR01243  93 KVVLAPTQpIRFGRDFVDYVKEFLLGKPISKGETV----------------------IVPVLEGALPFVVVSTQPAGFVY 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  179 VQPNSLVTWgagVPAAMGTSTAGQVsissPEIQIEELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGV 258
Cdd:TIGR01243 151 VTEATEVEI---REKPVREEIERKV----PKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGT 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  259 GKATLVRAVCD--GRRLVTLDGPEIGALAAGD---RVKAVASavQAVRHEGGVLLITDADALLPAAAEPVASL---ILSE 330
Cdd:TIGR01243 224 GKTLLAKAVANeaGAYFISINGPEIMSKYYGEseeRLREIFK--EAEENAPSIIFIDEIDAIAPKREEVTGEVekrVVAQ 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  331 LRTAV----ATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTG-DLNLDEIASRTPGFV 405
Cdd:TIGR01243 302 LLTLMdglkGRGRVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMPLAeDVDLDKLAEVTHGFV 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  406 VADLAALVREAALRAASRASADGRPPM--------------LHQDDLLGALTVIRPlsrSASDE--VTVGDVTLDDVGDM 469
Cdd:TIGR01243 382 GADLAALAKEAAMAALRRFIREGKINFeaeeipaevlkelkVTMKDFMEALKMVEP---SAIREvlVEVPNVRWSDIGGL 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  470 AAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVREL 549
Cdd:TIGR01243 459 EEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREI 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  550 FRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVF 629
Cdd:TIGR01243 539 FRKARQAAPAIIFFDEIDAIAPARGARFDTSVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLIL 618

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975  630 VEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSI 688
Cdd:TIGR01243 619 VPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESI 677
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 395-710 4.88e-104

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 321.19  E-value: 4.88e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 395 DEIASRTPGFVVADLAALVREAALRAASRASADGRPPMLHQDDLLGALTVIRPLSRSASDEVTVGDVTLDDVGDMAAAKQ 474
Cdd:COG1222    9 ENIKALLALIDALQERLGVELALLLQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 475 ALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALAstGQLSVH--AVKGSELMDKWVGSSEKAVRELFRR 552
Cdd:COG1222   89 EIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVA--GELGAPfiRVRGSELVSKYIGEGARNVREVFEL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 553 ARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFVEP 632
Cdd:COG1222  167 AREKAPSIIFIDEIDAIAARRTDDGTSGEVQRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLRPGRFDRVIEVPL 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 805023975 633 PDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSIDAanVTAADLATARETVRASLD 710
Cdd:COG1222  247 PDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIREGRDT--VTMEDLEKAIEKVKKKTE 322
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 472-630 1.51e-93

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 287.64  E-value: 1.51e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 472 AKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFR 551
Cdd:cd19511    1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975 552 RARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFV 630
Cdd:cd19511   81 KARQAAPCIIFFDEIDSLAPRRGQSDSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIYV 159
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 460-716 2.13e-71

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 237.81  E-value: 2.13e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 460 DVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWV 539
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 540 GSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGvsDRVVA----ALLTELDGIDPLRDVVMLGATNRPDLID 615
Cdd:PRK03992 207 GEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSG--DREVQrtlmQLLAEMDGFDPRGNVKIIAATNRIDILD 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 616 PALLRPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRsiDAANVTA 695
Cdd:PRK03992 285 PAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMNLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD--DRTEVTM 362

                        250       260
                 ....*....|....*....|.
gi 805023975 696 ADLATARETVRASLDPLQVAS 716
Cdd:PRK03992 363 EDFLKAIEKVMGKEEKDSMEE 383
cell_div_CdvC NF041006
cell division protein CdvC;
461-685 1.18e-46

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 169.92  E-value: 1.18e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 461 VTLDDVGDMAAAKQALTEAVLWPLQHPDTFArLGVepPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVG 540
Cdd:NF041006 100 VTFSDIVGLEDVKEALKEAIVYPSKRPDLFP-LGW--PRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLG 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 541 SSEKAVRELFRRARDSA-----PSLVFLDELDALAprrgQSFDSGVSD--RVVAALLTELDGI---DPLRDVVMLGATNR 610
Cdd:NF041006 177 EAEKNVAKIFKKAREKSkeegkPAIIFIDEIDALL----GVYSSEVGGevRVRNQFLKEMDGLqdkSENYHVYVIGATNK 252

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805023975 611 PDLIDPALLRpgRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMR 685
Cdd:NF041006 253 PWRLDEPFLR--RFQKRIYIPLPDREQRLELLKYYTSKIKLENDVDLDELAEMTEGYTASDIRDIVQAAHMRVVK 325
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 501-631 4.23e-43

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 151.98  E-value: 4.23e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  501 VLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSg 580
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDS- 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 805023975  581 VSDRVVAALLTELDGIDPL-RDVVMLGATNRPDLIDPALLrpGRLERLVFVE 631
Cdd:pfam00004  80 ESRRVVNQLLTELDGFTSSnSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 497-634 1.33e-14

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 71.64  E-value: 1.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975   497 PPRGVLLYGPPGCGKTFVVRALA---STGQLSVHAVKGSELM--------------DKWVGSSEKAVRELFRRARDSAPS 559
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALArelGPPGGGVIYIDGEDILeevldqllliivggKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805023975   560 LVFLDELDALAPRRGQsfdsgvSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPgRLERLVFVEPPD 634
Cdd:smart00382  81 VLILDEITSLLDAEQE------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 22-688 8.47e-125

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 388.88  E-value: 8.47e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975   22 DSRRGVVRLHPNAIAALGIREWDAVSLTGSR--TTAAVAGLAAADTAVGTVLLDDVTLSNAGLREGTEVIVSPVTVYGAR 99
Cdd:TIGR01243  13 DVGRGIVRIDRQTAARLGVEPGDFVEIEKGDrsVVAIVWPLRPDDEGRGIIRMDGYLRANAGVTIGDTVTVERAEVKEAK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  100 SVTLSGST-LATQSVPPVTLRQALLGKVMTVGDAVsllprdlgpgtstsaasralaaAVGISWTSELLTVTGVDPDGPVS 178
Cdd:TIGR01243  93 KVVLAPTQpIRFGRDFVDYVKEFLLGKPISKGETV----------------------IVPVLEGALPFVVVSTQPAGFVY 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  179 VQPNSLVTWgagVPAAMGTSTAGQVsissPEIQIEELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGV 258
Cdd:TIGR01243 151 VTEATEVEI---REKPVREEIERKV----PKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGT 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  259 GKATLVRAVCD--GRRLVTLDGPEIGALAAGD---RVKAVASavQAVRHEGGVLLITDADALLPAAAEPVASL---ILSE 330
Cdd:TIGR01243 224 GKTLLAKAVANeaGAYFISINGPEIMSKYYGEseeRLREIFK--EAEENAPSIIFIDEIDAIAPKREEVTGEVekrVVAQ 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  331 LRTAV----ATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTG-DLNLDEIASRTPGFV 405
Cdd:TIGR01243 302 LLTLMdglkGRGRVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMPLAeDVDLDKLAEVTHGFV 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  406 VADLAALVREAALRAASRASADGRPPM--------------LHQDDLLGALTVIRPlsrSASDE--VTVGDVTLDDVGDM 469
Cdd:TIGR01243 382 GADLAALAKEAAMAALRRFIREGKINFeaeeipaevlkelkVTMKDFMEALKMVEP---SAIREvlVEVPNVRWSDIGGL 458

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  470 AAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVREL 549
Cdd:TIGR01243 459 EEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREI 538

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  550 FRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVF 629
Cdd:TIGR01243 539 FRKARQAAPAIIFFDEIDAIAPARGARFDTSVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLIL 618

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975  630 VEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSI 688
Cdd:TIGR01243 619 VPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESI 677
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 395-710 4.88e-104

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 321.19  E-value: 4.88e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 395 DEIASRTPGFVVADLAALVREAALRAASRASADGRPPMLHQDDLLGALTVIRPLSRSASDEVTVGDVTLDDVGDMAAAKQ 474
Cdd:COG1222    9 ENIKALLALIDALQERLGVELALLLQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 475 ALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALAstGQLSVH--AVKGSELMDKWVGSSEKAVRELFRR 552
Cdd:COG1222   89 EIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVA--GELGAPfiRVRGSELVSKYIGEGARNVREVFEL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 553 ARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFVEP 632
Cdd:COG1222  167 AREKAPSIIFIDEIDAIAARRTDDGTSGEVQRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLRPGRFDRVIEVPL 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 805023975 633 PDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSIDAanVTAADLATARETVRASLD 710
Cdd:COG1222  247 PDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIREGRDT--VTMEDLEKAIEKVKKKTE 322
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 472-630 1.51e-93

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 287.64  E-value: 1.51e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 472 AKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFR 551
Cdd:cd19511    1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975 552 RARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFV 630
Cdd:cd19511   81 KARQAAPCIIFFDEIDSLAPRRGQSDSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIYV 159
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 331-709 3.13e-83

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 269.47  E-value: 3.13e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 331 LRTAVATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTGDLNLDEIASRTPGFVVADLA 410
Cdd:COG0464   23 LRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLLL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 411 ALVREAALRAASRASADGRPPMLHQDDLLGALTVIRPLSRSASDEV-TVGDVTLDDVGDMAAAKQALTEAVLWPLQHPDT 489
Cdd:COG0464  103 LLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELlELREAILDDLGGLEEVKEELRELVALPLKRPEL 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 490 FARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDELDAL 569
Cdd:COG0464  183 REEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADAL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 570 APRRGQSfDSGVSDRVVAALLTELDGIDPlrDVVMLGATNRPDLIDPALLRpgRLERLVFVEPPDAAARREILRTAGKSI 649
Cdd:COG0464  263 AGKRGEV-GDGVGRRVVNTLLTEMEELRS--DVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRKR 337

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 650 PLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRrsIDAANVTAADLATARETVRASL 709
Cdd:COG0464  338 PLDEDVDLEELAEATEGLSGADIRNVVRRAALQALR--LGREPVTTEDLLEALEREDIFL 395
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 472-630 2.72e-73

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 234.70  E-value: 2.72e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 472 AKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFR 551
Cdd:cd19529    1 VKQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975 552 RARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFV 630
Cdd:cd19529   81 KARQVAPCVIFFDEIDSIAPRRGTTGDSGVTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 460-716 2.13e-71

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 237.81  E-value: 2.13e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 460 DVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWV 539
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 540 GSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGvsDRVVA----ALLTELDGIDPLRDVVMLGATNRPDLID 615
Cdd:PRK03992 207 GEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSG--DREVQrtlmQLLAEMDGFDPRGNVKIIAATNRIDILD 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 616 PALLRPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRsiDAANVTA 695
Cdd:PRK03992 285 PAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKMNLADDVDLEELAELTEGASGADLKAICTEAGMFAIRD--DRTEVTM 362

                        250       260
                 ....*....|....*....|.
gi 805023975 696 ADLATARETVRASLDPLQVAS 716
Cdd:PRK03992 363 EDFLKAIEKVMGKEEKDSMEE 383
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 445-714 1.07e-70

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 245.20  E-value: 1.07e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  445 IRPLSRSASDEVTVGDVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQL 524
Cdd:TIGR01243 159 IREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGA 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  525 SVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSgVSDRVVAALLTELDGIDPLRDVVM 604
Cdd:TIGR01243 239 YFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGE-VEKRVVAQLLTLMDGLKGRGRVIV 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  605 LGATNRPDLIDPALLRPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAM 684
Cdd:TIGR01243 318 IGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLDKLAEVTHGFVGADLAALAKEAAMAAL 397

                         250       260       270
                  ....*....|....*....|....*....|
gi 805023975  685 RRSIDAANVTaadlATARETVRASLDPLQV 714
Cdd:TIGR01243 398 RRFIREGKIN----FEAEEIPAEVLKELKV 423
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
 460-705 4.48e-67

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 225.45  E-value: 4.48e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  460 DVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWV 539
Cdd:TIGR01242 118 NVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVRKYI 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  540 GSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGVSD--RVVAALLTELDGIDPLRDVVMLGATNRPDLIDPA 617
Cdd:TIGR01242 198 GEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRTDSGTSGDREvqRTLMQLLAELDGFDPRGNVKVIAATNRPDILDPA 277

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  618 LLRPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSIDAanVTAAD 697
Cdd:TIGR01242 278 LLRPGRFDRIIEVPLPDFEGRLEILKIHTRKMKLAEDVDLEAIAKMTEGASGADLKAICTEAGMFAIREERDY--VTMDD 355


                  ....*...
gi 805023975  698 LATARETV 705
Cdd:TIGR01242 356 FIKAVEKV 363
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 461-709 6.47e-63

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 218.31  E-value: 6.47e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  461 VTLDDVGDMAAAKQALTEAVLWpLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVG 540
Cdd:TIGR01241  52 VTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  541 SSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDR--VVAALLTELDGIDPLRDVVMLGATNRPDLIDPAL 618
Cdd:TIGR01241 131 VGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGNDEReqTLNQLLVEMDGFGTNTGVIVIAATNRPDVLDPAL 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  619 LRPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSIDAanVTAADL 698
Cdd:TIGR01241 211 LRPGRFDRQVVVDLPDIKGREEILKVHAKNKKLAPDVDLKAVARRTPGFSGADLANLLNEAALLAARKNKTE--ITMNDI 288

                         250
                  ....*....|.
gi 805023975  699 ATARETVRASL 709
Cdd:TIGR01241 289 EEAIDRVIAGP 299
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 473-630 3.17e-61

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 202.74  E-value: 3.17e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 473 KQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRR 552
Cdd:cd19528    2 KRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 553 ARDSAPSLVFLDELDALAPRRGQSFD--SGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFV 630
Cdd:cd19528   82 ARAAAPCVLFFDELDSIAKARGGNIGdaGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 161
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 465-628 2.99e-60

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 200.21  E-value: 2.99e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 465 DVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEK 544
Cdd:cd19503    1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 545 AVRELFRRARDSAPSLVFLDELDALAPRRGQSfDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRL 624
Cdd:cd19503   81 NLREIFEEARSHAPSIIFIDEIDALAPKREED-QREVERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPGRF 159


                 ....
gi 805023975 625 ERLV 628
Cdd:cd19503  160 DREV 163
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 472-629 3.40e-59

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 196.88  E-value: 3.40e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 472 AKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFR 551
Cdd:cd19526    1 VKKALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 805023975 552 RARDSAPSLVFLDELDALAPRRGQSfDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVF 629
Cdd:cd19526   81 RAQSAKPCILFFDEFDSIAPKRGHD-STGVTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 460-686 1.30e-58

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 203.84  E-value: 1.30e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 460 DVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWV 539
Cdd:PTZ00454 141 DVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYL 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 540 GSSEKAVRELFRRARDSAPSLVFLDELDALAPRRgqsFDSGVS-----DRVVAALLTELDGIDPLRDVVMLGATNRPDLI 614
Cdd:PTZ00454 221 GEGPRMVRDVFRLARENAPSIIFIDEVDSIATKR---FDAQTGadrevQRILLELLNQMDGFDQTTNVKVIMATNRADTL 297

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 805023975 615 DPALLRPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRR 686
Cdd:PTZ00454 298 DPALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKMNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRK 369
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 473-630 7.05e-58

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 193.47  E-value: 7.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 473 KQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRR 552
Cdd:cd19530    5 REELTMSILRPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQR 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 805023975 553 ARDSAPSLVFLDELDALAPRRGQSfDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFV 630
Cdd:cd19530   85 ARASAPCVIFFDEVDALVPKRGDG-GSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKTLYV 161
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 462-628 2.36e-57

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 192.55  E-value: 2.36e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 462 TLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGS 541
Cdd:cd19502    1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 542 SEKAVRELFRRARDSAPSLVFLDELDALAPRRgqsFDSGVS-----DRVVAALLTELDGIDPLRDVVMLGATNRPDLIDP 616
Cdd:cd19502   81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKR---FDSGTGgdrevQRTMLELLNQLDGFDPRGNIKVIMATNRPDILDP 157

                        170
                 ....*....|..
gi 805023975 617 ALLRPGRLERLV 628
Cdd:cd19502  158 ALLRPGRFDRKI 169
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 462-705 3.38e-57

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 201.15  E-value: 3.38e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 462 TLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGS 541
Cdd:PTZ00361 181 SYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGD 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 542 SEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGVSD--RVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALL 619
Cdd:PTZ00361 261 GPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKEiqRTMLELLNQLDGFDSRGDVKVIMATNRIESLDPALI 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 620 RPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSidAANVTAADLA 699
Cdd:PTZ00361 341 RPGRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIMAKDELSGADIKAICTEAGLLALRER--RMKVTQADFR 418


                 ....*.
gi 805023975 700 TARETV 705
Cdd:PTZ00361 419 KAKEKV 424
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
461-707 1.11e-55

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 200.26  E-value: 1.11e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 461 VTLDDVGDMAAAKQALTEAVLWpLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALAstGQLSVH--AVKGSELMDKW 538
Cdd:COG0465  139 VTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVA--GEAGVPffSISGSDFVEMF 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 539 VGSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDR--VVAALLTELDGIDPLRDVVMLGATNRPDLIDP 616
Cdd:COG0465  216 VGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGGHDEReqTLNQLLVEMDGFEGNEGVIVIAATNRPDVLDP 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 617 ALLRPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRsiDAANVTAA 696
Cdd:COG0465  296 ALLRPGRFDRQVVVDLPDVKGREAILKVHARKKPLAPDVDLEVIARRTPGFSGADLANLVNEAALLAARR--NKKAVTME 373

                        250
                 ....*....|.
gi 805023975 697 DLATARETVRA 707
Cdd:COG0465  374 DFEEAIDRVIA 384
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 465-626 3.50e-53

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 181.10  E-value: 3.50e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 465 DVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEK 544
Cdd:cd19519    1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 545 AVRELFRRARDSAPSLVFLDELDALAPRRGQSfDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRL 624
Cdd:cd19519   81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKT-HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRF 159


                 ..
gi 805023975 625 ER 626
Cdd:cd19519  160 DR 161
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 472-630 3.02e-52

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 178.25  E-value: 3.02e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 472 AKQALTEAVLWPLQHPDTFaRLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFR 551
Cdd:cd19481    1 LKASLREAVEAPRRGSRLR-RYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975 552 RARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFV 630
Cdd:cd19481   80 RARRLAPCILFIDEIDAIGRKRDSSGESGELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIEF 158
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
463-701 1.11e-51

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 179.69  E-value: 1.11e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 463 LDDVGDMAAAKQALTEAVLWpLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSS 542
Cdd:COG1223    1 LDDVVGQEEAKKKLKLIIKE-LRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGET 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 543 EKAVRELFRRARdSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDplRDVVMLGATNRPDLIDPALLRpg 622
Cdd:COG1223   80 ARNLRKLFDFAR-RAPCVIFFDEFDAIAKDRGDQNDVGEVKRVVNALLQELDGLP--SGSVVIAATNHPELLDSALWR-- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 623 RLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADcvalLREAALTAMRRSI--DAANVTAADLAT 700
Cdd:COG1223  155 RFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLEGLSGAD----IEKVLKTALKKAIleDREKVTKEDLEE 230


                 .
gi 805023975 701 A 701
Cdd:COG1223  231 A 231
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 473-630 1.54e-51

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 176.16  E-value: 1.54e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 473 KQALTEAVLWPLQHPDTFArLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRR 552
Cdd:cd19527    2 KKEILDTIQLPLEHPELFS-SGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 553 ARDSAPSLVFLDELDALAPRRGQSFDS-GVSDRVVAALLTELDGI-DPLRDVVMLGATNRPDLIDPALLRPGRLERLVFV 630
Cdd:cd19527   81 ARDAKPCVIFFDELDSLAPSRGNSGDSgGVMDRVVSQLLAELDGMsSSGQDVFVIGATNRPDLLDPALLRPGRFDKLLYL 160
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
 458-697 1.59e-51

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 187.22  E-value: 1.59e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  458 VGDVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHA--------- 528
Cdd:TIGR03689 176 VPDVTYADIGGLGSQIEQIRDAVELPFLHPELYREYGLKPPKGVLLYGPPGCGKTLIAKAVANSLAARIGAegggksyfl 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  529 -VKGSELMDKWVGSSEKAVRELFRRARDSA----PSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGIDPLRDVV 603
Cdd:TIGR03689 256 nIKGPELLNKYVGETERQIRLIFQRAREKAsegrPVIVFFDEMDSLFRTRGSGVSSDVETTVVPQLLAEIDGVESLDNVI 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  604 MLGATNRPDLIDPALLRPGRLERLVFVEPPDAAARREILRTAgksipLSSDVDLDEVAAGLDGYSAADCVALLREA--AL 681
Cdd:TIGR03689 336 VIGASNREDMIDPAILRPGRLDVKIRIERPDAEAAADIFAKY-----LTDDLPLPEDLAAHDGDREATAAALIQRVvdAL 410

                         250
                  ....*....|....*.
gi 805023975  682 TAMRRSIDAANVTAAD 697
Cdd:TIGR03689 411 YARSEANRYVEVTYAN 426
ftsH CHL00176
cell division protein; Validated
 460-702 4.13e-51

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 188.72  E-value: 4.13e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 460 DVTLDDVGDMAAAKQALTEAVLWpLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWV 539
Cdd:CHL00176 179 GITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFV 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 540 GSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGqsfdSGV------SDRVVAALLTELDGIDPLRDVVMLGATNRPDL 613
Cdd:CHL00176 258 GVGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRG----AGIgggndeREQTLNQLLTEMDGFKGNKGVIVIAATNRVDI 333

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 614 IDPALLRPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMRRSIDAANV 693
Cdd:CHL00176 334 LDAALLRPGRFDRQITVSLPDREGRLDILKVHARNKKLSPDVSLELIARRTPGFSGADLANLLNEAAILTARRKKATITM 413


                 ....*....
gi 805023975 694 TAADLATAR 702
Cdd:CHL00176 414 KEIDTAIDR 422
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 461-630 3.58e-49

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 170.11  E-value: 3.58e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 461 VTLDDVGDMAAAKQALTEAVLWpLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVG 540
Cdd:cd19501    1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 541 SSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDR--VVAALLTELDGIDPLRDVVMLGATNRPDLIDPAL 618
Cdd:cd19501   80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHDEReqTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPAL 159

                        170
                 ....*....|..
gi 805023975 619 LRPGRLERLVFV 630
Cdd:cd19501  160 LRPGRFDRQVYV 171
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
462-685 8.38e-49

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 182.16  E-value: 8.38e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 462 TLDDVGDMAAAKQALTEAVLWpLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGS 541
Cdd:PRK10733 150 TFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGV 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 542 SEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDR--VVAALLTELDGIDPLRDVVMLGATNRPDLIDPALL 619
Cdd:PRK10733 229 GASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGHDEReqTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALL 308

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 805023975 620 RPGRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMR 685
Cdd:PRK10733 309 RPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAAR 374
cell_div_CdvC NF041006
cell division protein CdvC;
461-685 1.18e-46

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 169.92  E-value: 1.18e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 461 VTLDDVGDMAAAKQALTEAVLWPLQHPDTFArLGVepPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVG 540
Cdd:NF041006 100 VTFSDIVGLEDVKEALKEAIVYPSKRPDLFP-LGW--PRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLG 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 541 SSEKAVRELFRRARDSA-----PSLVFLDELDALAprrgQSFDSGVSD--RVVAALLTELDGI---DPLRDVVMLGATNR 610
Cdd:NF041006 177 EAEKNVAKIFKKAREKSkeegkPAIIFIDEIDALL----GVYSSEVGGevRVRNQFLKEMDGLqdkSENYHVYVIGATNK 252

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805023975 611 PDLIDPALLRpgRLERLVFVEPPDAAARREILRTAGKSIPLSSDVDLDEVAAGLDGYSAADCVALLREAALTAMR 685
Cdd:NF041006 253 PWRLDEPFLR--RFQKRIYIPLPDREQRLELLKYYTSKIKLENDVDLDELAEMTEGYTASDIRDIVQAAHMRVVK 325
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 466-630 1.70e-45

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 159.83  E-value: 1.70e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 466 VGDMAAAKQALTEAVLWPLQHPDTFaRLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKA 545
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLF-PGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 546 VRELFRRARDSAPSLVFLDELDALAPRRGQSfDSGVSDRVVAALLTELDGI--DPLRDVVMLGATNRPDLIDPALLRpgR 623
Cdd:cd19509   80 VRALFALARELQPSIIFIDEIDSLLSERGSG-EHEASRRVKTEFLVQMDGVlnKPEDRVLVLGATNRPWELDEAFLR--R 156


                 ....*..
gi 805023975 624 LERLVFV 630
Cdd:cd19509  157 FEKRIYI 163
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 465-626 1.39e-44

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 157.67  E-value: 1.39e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 465 DVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALA---STG--QLSVHAVKGSELMDKWV 539
Cdd:cd19517    1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAaecSKGgqKVSFFMRKGADCLSKWV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 540 GSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSgVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALL 619
Cdd:cd19517   81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQ-IHASIVSTLLALMDGLDNRGQVVVIGATNRPDALDPALR 159


                 ....*..
gi 805023975 620 RPGRLER 626
Cdd:cd19517  160 RPGRFDR 166
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 465-626 7.74e-44

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 155.64  E-value: 7.74e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 465 DVGDMAAAKQALTEAVLWPLQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEK 544
Cdd:cd19518    1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 545 AVRELFRRARDSAPSLVFLDELDALAPRRgQSFDSGVSDRVVAALLTELDGIDPLRD----VVMLGATNRPDLIDPALLR 620
Cdd:cd19518   81 KIRELFDQAISNAPCIVFIDEIDAITPKR-ESAQREMERRIVSQLLTCMDELNNEKTaggpVLVIGATNRPDSLDPALRR 159


                 ....*.
gi 805023975 621 PGRLER 626
Cdd:cd19518  160 AGRFDR 165
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 501-631 4.23e-43

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 151.98  E-value: 4.23e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  501 VLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSg 580
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDS- 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 805023975  581 VSDRVVAALLTELDGIDPL-RDVVMLGATNRPDLIDPALLrpGRLERLVFVE 631
Cdd:pfam00004  80 ESRRVVNQLLTELDGFTSSnSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 487-625 7.17e-37

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 136.08  E-value: 7.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 487 PDTFARLGVEPPRGVLLYGPPGCGKTFVVRALAST-GQLSVHAVKGSELMDKWVGSSEKAVRELFRRAR--------DSA 557
Cdd:cd19504   24 PEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMlNAREPKIVNGPEILNKYVGESEANIRKLFADAEeeqrrlgaNSG 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975 558 PSLVFLDELDALAPRRGQSFD-SGVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLE 625
Cdd:cd19504  104 LHIIIFDEIDAICKQRGSMAGsTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRKDLIDEALLRPGRLE 172
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 465-630 1.09e-36

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 135.50  E-value: 1.09e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 465 DVGDMAAAKQALTEAVLWPLQHPDTFArlGVEPP-RGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSE 543
Cdd:cd19522    1 DIADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 544 KAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDGI-------DPLRDVVMLGATNRPDLIDP 616
Cdd:cd19522   79 KLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKSELLVQMDGVggasendDPSKMVMVLAATNFPWDIDE 158

                        170
                 ....*....|....
gi 805023975 617 ALLRpgRLERLVFV 630
Cdd:cd19522  159 ALRR--RLEKRIYI 170
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 460-630 1.11e-36

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 135.37  E-value: 1.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 460 DVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARlGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWV 539
Cdd:cd19521    3 NVKWEDVAGLEGAKEALKEAVILPVKFPHLFTG-NRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 540 GSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSfDSGVSDRVVAALLTELDGIDPLRD-VVMLGATNRPDLIDPAL 618
Cdd:cd19521   82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEG-ESEASRRIKTELLVQMNGVGNDSQgVLVLGATNIPWQLDSAI 160

                        170
                 ....*....|..
gi 805023975 619 LRpgRLERLVFV 630
Cdd:cd19521  161 RR--RFEKRIYI 170
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 460-630 3.10e-36

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 134.73  E-value: 3.10e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 460 DVTLDDVGDMAAAKQALTEAVLWPLQHPDTFARLGVePPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWV 539
Cdd:cd19525   18 PINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRG-PPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 540 GSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSfDSGVSDRVVAALLTELDGIDPLRD--VVMLGATNRPDLIDPA 617
Cdd:cd19525   97 GEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEG-EHESSRRIKTEFLVQLDGATTSSEdrILVVGATNRPQEIDEA 175

                        170
                 ....*....|...
gi 805023975 618 LLRpgRLERLVFV 630
Cdd:cd19525  176 ARR--RLVKRLYI 186
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 465-625 5.93e-34

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 127.54  E-value: 5.93e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 465 DVGDMAAAKQALTEAVLWPLQHPDTFARLGV-EPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSE 543
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 544 KAVRELFRRARDSAPSLVFLDELDALAPRRgQSFDSGVSDRVVAALLTELDGI--DPLRDVVMLGATNRPDLIDPALLR- 620
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR-SSTDHEATAMMKAEFMSLWDGLstDGNCRVIVMGATNRPQDLDEAILRr 159


                 ....*.
gi 805023975 621 -PGRLE 625
Cdd:cd19520  160 mPKRFH 165
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 465-630 2.18e-31

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 120.34  E-value: 2.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 465 DVGDMAAAKQALTEAVLWPLQHPDTFARLGVePPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEK 544
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFTGLRA-PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 545 AVRELFRRARDSAPSLVFLDELDALAPRRGQSfDSGVSDRVVAALLTELDGI--DPLRDVVMLGATNRPDLIDPALLRpg 622
Cdd:cd19524   80 LVRALFAVARELQPSIIFIDEVDSLLSERSEG-EHEASRRLKTEFLIEFDGVqsNGDDRVLVMGATNRPQELDDAVLR-- 156


                 ....*...
gi 805023975 623 RLERLVFV 630
Cdd:cd19524  157 RFTKRVYV 164
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 465-620 2.36e-23

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 97.26  E-value: 2.36e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 465 DVGDMAAAKQALTEAVLWPLQHPDTFARLgVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEK 544
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAFSGL-LRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEK 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 805023975 545 AVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGvsDRVVAALLTELDGI--DPLRDVVMLGATNRPDLIDPALLR 620
Cdd:cd19523   80 ILQASFLAARCRQPSVLFISDLDALLSSQDDEASPV--GRLQVELLAQLDGVlgSGEDGVLVVCTTSKPEEIDESLRR 155
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 496-632 3.23e-23

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 96.45  E-value: 3.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 496 EPPRGVLLYGPPGCGKTFVVRALA---STGQLSVHAVKGSELMDKWVGSSEK---AVRELFRRARDSAPSLVFLDELDAL 569
Cdd:cd00009   17 PPPKNLLLYGPPGTGKTTLARAIAnelFRPGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPGVLFIDEIDSL 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 805023975 570 APRrgqsfdsgVSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFVEP 632
Cdd:cd00009   97 SRG--------AQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIPL 151
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 492-630 5.84e-19

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 84.34  E-value: 5.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 492 RLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWVGSSEKAVRELFRRARDSAPSLVFLDELDALAP 571
Cdd:cd19507   25 AYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEKGFS 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975 572 RRGQSFDSGVSDRVVAALLTELDgiDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFV 630
Cdd:cd19507  105 NADSKGDSGTSSRVLGTFLTWLQ--EKKKPVFVVATANNVQSLPPELLRKGRFDEIFFV 161
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 484-630 4.87e-17

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 78.55  E-value: 4.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 484 LQHPDTFARLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSElmdkwVGSSEKAVRELFRRARDSapSLVFL 563
Cdd:cd19510    9 IKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSE-----VVLTDDRLNHLLNTAPKQ--SIILL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 805023975 564 DELDA---LAPRRGQS-FDSGVSDRV-VAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLVFV 630
Cdd:cd19510   82 EDIDAafeSREHNKKNpSAYGGLSRVtFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
ycf46 CHL00195
Ycf46; Provisional
 460-727 3.53e-16

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 81.99  E-value: 3.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 460 DVTLDDVGDMAAAKQalteavlWPLQHPDTFAR----LGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELM 535
Cdd:CHL00195 224 NEKISDIGGLDNLKD-------WLKKRSTSFSKqasnYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLF 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 536 DKWVGSSEKAVRELFRRARDSAPSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTELDgiDPLRDVVMLGATNRPDLID 615
Cdd:CHL00195 297 GGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFSNSESKGDSGTTNRVLATFITWLS--EKKSPVFVVATANNIDLLP 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 616 PALLRPGRLERLVFVEPPDAAARREILRTAGKSI-PLS-SDVDLDEVAAGLDGYSAADcvalLREAALTAMRRSIDAA-N 692
Cdd:CHL00195 375 LEILRKGRFDEIFFLDLPSLEEREKIFKIHLQKFrPKSwKKYDIKKLSKLSNKFSGAE----IEQSIIEAMYIAFYEKrE 450

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 805023975 693 VTAADLATA-RETV-RASLDPLQVASLRKFGTKGDLR 727
Cdd:CHL00195 451 FTTDDILLAlKQFIpLAQTEKEQIEALQNWASSGRIR 487
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 201-415 1.24e-14

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 75.81  E-value: 1.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 201 GQVSISSPEIQIEELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDG 278
Cdd:COG1222   66 TAVPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGelGAPFIRVRG 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 279 PE-----IGALAAgdRVKAVASAvqAVRHEGGVLLI--------TDADALLPAAAEPVASLILSELRTAVATAGVVLIAT 345
Cdd:COG1222  146 SElvskyIGEGAR--NVREVFEL--AREKAPSIIFIdeidaiaaRRTDDGTSGEVQRTVNQLLAELDGFESRGDVLIIAA 221

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 805023975 346 SARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPT-GDLNLDEIASRTPGFVVADLAALVRE 415
Cdd:COG1222  222 TNRPDLLDPALLRPGRFDRVIEVPLPDEEAREEILKIHLRDMPLaDDVDLDKLAKLTEGFSGADLKAIVTE 292
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 497-634 1.33e-14

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 71.64  E-value: 1.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975   497 PPRGVLLYGPPGCGKTFVVRALA---STGQLSVHAVKGSELM--------------DKWVGSSEKAVRELFRRARDSAPS 559
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALArelGPPGGGVIYIDGEDILeevldqllliivggKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805023975   560 LVFLDELDALAPRRGQsfdsgvSDRVVAALLTELDGIDPLRDVVMLGATNRPDLIDPALLRPgRLERLVFVEPPD 634
Cdd:smart00382  81 VLILDEITSLLDAEQE------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
188-415 1.69e-14

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 77.00  E-value: 1.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 188 GAGVPAAM--GTSTAGQVSISSPEIQIEELKG---AQPQAAKLTEWLKlaldEPHLLQTLGAGTNLGVLVSGPAGVGKAT 262
Cdd:PRK10733 125 GGGGKGAMsfGKSKARMLTEDQIKTTFADVAGcdeAKEEVAELVEYLR----EPSRFQKLGGKIPKGVLMVGPPGTGKTL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 263 LVRAVCDGRRL--VTLDGPE-------IGALAAGDRVKAVASA---------VQAVRHEGGVLLitdadALLPAAAEPVA 324
Cdd:PRK10733 201 LAKAIAGEAKVpfFTISGSDfvemfvgVGASRVRDMFEQAKKAapciifideIDAVGRQRGAGL-----GGGHDEREQTL 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 325 SLILSELRTAVATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTG-DLNLDEIASRTPG 403
Cdd:PRK10733 276 NQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLApDIDAAIIARGTPG 355

                        250
                 ....*....|..
gi 805023975 404 FVVADLAALVRE 415
Cdd:PRK10733 356 FSGADLANLVNE 367
CDC48_N smart01073
Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...
 12-93 4.33e-14

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases is a substrate 185-residue recognition domain.


Pssm-ID: 215012 [Multi-domain]  Cd Length: 82  Bit Score: 68.02  E-value: 4.33e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975    12 LTARLNTSAVDSRRGVVRLHPNAIAALGIREWDAVSLTGSRTTAAVAGLAAADTAVGTVLLDDVTLSNAGLREGTEVIVS 91
Cdd:smart01073   1 LRVAEAPSDEDVGRGIARLSPEDMDELGLFPGDYVLITGKRRTVAIVWPAYPEDPGGIIRIDGVQRKNAGVSIGDTVTVR 80


                   ..
gi 805023975    92 PV 93
Cdd:smart01073  81 KA 82
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 209-443 6.84e-14

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 74.18  E-value: 6.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 209 EIQIEELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALAA 286
Cdd:COG0464  153 EAILDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGelGLPLIEVDLSDLVSKYV 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 287 GDRVKAVASAVQAVR-HEGGVLLIT---DADALLPAAAEPVASLILSELRTAVA--TAGVVLIATSARPDQLDarlrsPE 360
Cdd:COG0464  233 GETEKNLREVFDKARgLAPCVLFIDeadALAGKRGEVGDGVGRRVVNTLLTEMEelRSDVVVIAATNRPDLLD-----PA 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 361 L---CDRELGLPLPDAATRKSLLEALLNPVP-TGDLNLDEIASRTPGFVVADLAALVREAALRAASRASadgrpPMLHQD 436
Cdd:COG0464  308 LlrrFDEIIFFPLPDAEERLEIFRIHLRKRPlDEDVDLEELAEATEGLSGADIRNVVRRAALQALRLGR-----EPVTTE 382


                 ....*..
gi 805023975 437 DLLGALT 443
Cdd:COG0464  383 DLLEALE 389
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 250-370 1.04e-12

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 65.69  E-value: 1.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  250 VLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALAAGDRVKAVASAVQAVRHEG-GVLLI-------TDADALLPAA 319
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKelGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLApCVIFIdeidalaGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 805023975  320 AEPVASLILSEL-RTAVATAGVVLIATSARPDQLDARLRSpeLCDRELGLPL 370
Cdd:pfam00004  81 SRRVVNQLLTELdGFTSSNSKVIVIAATNRPDKLDPALLG--RFDRIIEFPL 130
CDC48_N pfam02359
Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel ...
 22-95 4.73e-12

Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases pfam00004 is a substrate 185-residue recognition domain.


Pssm-ID: 426738  Cd Length: 85  Bit Score: 62.21  E-value: 4.73e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805023975   22 DSRRGVVRLHPNAIAALGIREWDAVSLTGSRTTAAVA-GLAAADTAVGTVLLDDVTLSNAGLREGTEVIVSPVTV 95
Cdd:pfam02359  11 DVGRGIARLNPEDMEELGLFPGDVVEIKGKRKTVAIVwSAYPEDEGPGIIRMDGVTRKNAGVSIGDTVTVRPAEV 85
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 499-618 2.65e-11

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 63.23  E-value: 2.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 499 RGVLLYGPPGCGKTFVVRALAStgQLSVH-----------AVKGSELMDKWVGSSEKAVRELFRRAR---DSAPSLVFL- 563
Cdd:cd19508   53 RLVLLHGPPGTGKTSLCKALAQ--KLSIRlssryrygqliEINSHSLFSKWFSESGKLVTKMFQKIQeliDDKDALVFVl 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 564 -DELDALAPRRgQSFDSGV--SD--RVVAALLTELDGIDPLRDVVMLGATNRPDLIDPAL 618
Cdd:cd19508  131 iDEVESLAAAR-SASSSGTepSDaiRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAF 189
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 214-365 6.47e-11

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 61.54  E-value: 6.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 214 ELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALAAGDRVK 291
Cdd:cd19503    1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANeaGANFLSISGPSIVSKYLGESEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 292 AVASAVQAVRHEGGVLL----ITDADALLPAAAEPVASLILSELRT----AVATAGVVLIATSARPDQLDARLRSPELCD 363
Cdd:cd19503   81 NLREIFEEARSHAPSIIfideIDALAPKREEDQREVERRVVAQLLTlmdgMSSRGKVVVIAATNRPDAIDPALRRPGRFD 160


                 ..
gi 805023975 364 RE 365
Cdd:cd19503  161 RE 162
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 214-369 1.93e-09

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 57.06  E-value: 1.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 214 ELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALAAGDRVK 291
Cdd:cd19519    1 DIGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANetGAFFFLINGPEIMSKLAGESES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 292 AVASAV-QAVRHEGGVLLITDADALLPAAAE---PVASLILSELRTAV----ATAGVVLIATSARPDQLDARLRSPELCD 363
Cdd:cd19519   81 NLRKAFeEAEKNAPAIIFIDEIDAIAPKREKthgEVERRIVSQLLTLMdglkQRAHVIVMAATNRPNSIDPALRRFGRFD 160


                 ....*.
gi 805023975 364 RELGLP 369
Cdd:cd19519  161 REIDIG 166
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 654-698 7.29e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 51.77  E-value: 7.29e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 805023975  654 DVDLDEVAAGLDGYSAADCVALLREAALTAMRRSIDAanVTAADL 698
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEA--VTQEDL 43
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
336-415 1.22e-08

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 58.12  E-value: 1.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 336 ATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTG-DLNLDEIASRTPGFVVADLAALVR 414
Cdd:COG0465  277 GNEGVIVIAATNRPDVLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARKKPLApDVDLEVIARRTPGFSGADLANLVN 356


                 .
gi 805023975 415 E 415
Cdd:COG0465  357 E 357
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 225-359 4.27e-08

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 53.06  E-value: 4.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 225 LTEWLKLALDEPHL---LQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALAAGDRVKAVASAVQ- 298
Cdd:cd19481    1 LKASLREAVEAPRRgsrLRRYGLGLPKGILLYGPPGTGKTLLAKALAGelGLPLIVVKLSSLLSKYVGESEKNLRKIFEr 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975 299 AVRHEGGVLLI--------TDADALLPAAAEPVASLILSELRTAVATAGVVLIATSARPDQLDARLRSP 359
Cdd:cd19481   81 ARRLAPCILFIdeidaigrKRDSSGESGELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRP 149
ftsH CHL00176
cell division protein; Validated
 212-415 1.89e-07

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 54.67  E-value: 1.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 212 IEELKgaqpqaAKLTEWLKLaLDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVC----------DGRRLVTLdgpEI 281
Cdd:CHL00176 188 IEEAK------EEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAgeaevpffsiSGSEFVEM---FV 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 282 GALAAgdRV-----KAVASA--------VQAVRHEGGVllitdADALLPAAAEPVASLILSELRTAVATAGVVLIATSAR 348
Cdd:CHL00176 258 GVGAA--RVrdlfkKAKENSpcivfideIDAVGRQRGA-----GIGGGNDEREQTLNQLLTEMDGFKGNKGVIVIAATNR 330

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 805023975 349 PDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTG-DLNLDEIASRTPGFVVADLAALVRE 415
Cdd:CHL00176 331 VDILDAALLRPGRFDRQITVSLPDREGRLDILKVHARNKKLSpDVSLELIARRTPGFSGADLANLLNE 398
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 225-366 2.00e-07

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 51.34  E-value: 2.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 225 LTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALAAGDRVKAVASAVQAVRH 302
Cdd:cd19529    5 LKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATesNANFISVKGPELLSKWVGESEKAIREIFRKARQ 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 805023975 303 ---------EGGVLLITDADALLPAAAEPVASLILSELRTAVATAGVVLIATSARPDQLDARLRSPELCDREL 366
Cdd:cd19529   85 vapcviffdEIDSIAPRRGTTGDSGVTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLI 157
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
496-706 2.36e-07

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 53.70  E-value: 2.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 496 EPPRGVLLYGPPGCGKTFVVRALAStgQLSVHAVKGSELM-----DKWVGSSEKAV-RELFRRARDSAPslvfldeldal 569
Cdd:COG1474   49 ERPSNVLIYGPTGTGKTAVAKYVLE--ELEEEAEERGVDVrvvyvNCRQASTRYRVlSRILEELGSGED----------- 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 570 APRRGQSFDSgVSDRVVAALLTE-------LDGIDPLRD---------------------VVMLGATNRPDLI---DPAL 618
Cdd:COG1474  116 IPSTGLSTDE-LFDRLYEALDERdgvlvvvLDEIDYLVDdegddllyqllraneelegarVGVIGISNDLEFLenlDPRV 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 619 LRPGRLERLVFvEPPDAAARREILRT----AGKSIPLSSDVdLDEVAAgldgYSAADC------VALLREAALTAMRRsi 688
Cdd:COG1474  195 KSSLGEEEIVF-PPYDADELRDILEDraelAFYDGVLSDEV-IPLIAA----LAAQEHgdarkaIDLLRVAGEIAERE-- 266

                        250
                 ....*....|....*...
gi 805023975 689 DAANVTAADLATARETVR 706
Cdd:COG1474  267 GSDRVTEEHVREAREKIE 284
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 492-628 6.88e-07

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 49.68  E-value: 6.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 492 RLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSELMDKWV-----------GSSEKAVREL---FRRARDSA 557
Cdd:cd19505    6 RLGLSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYNKPdfgnddwidgmLILKESLHRLnlqFELAKAMS 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 805023975 558 PSLVFLDELDALAPRRGQSFDSGVSDRVVAALLTEL---DGIDPLRDVVMLGATNRPDLIDPALLRPGRLERLV 628
Cdd:cd19505   86 PCIIWIPNIHELNVNRSTQNLEEDPKLLLGLLLNYLsrdFEKSSTRNILVIASTHIPQKVDPALIAPNRLDTCI 159
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 499-618 1.40e-06

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 48.68  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 499 RGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGSEL--MDKwvgSSEKAVRELFRRARDSAPSL-VFLDELDALAPRRGQ 575
Cdd:cd19512   23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVapMGR---EGVTAIHKVFDWANTSRRGLlLFVDEADAFLRKRST 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 805023975 576 SFDSGVSDRVVAALLTELDgiDPLRDVVMLGATNRPDLIDPAL 618
Cdd:cd19512  100 EKISEDLRAALNAFLYRTG--EQSNKFMLVLASNQPEQFDWAI 140
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 224-359 6.28e-06

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 46.73  E-value: 6.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 224 KLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALAAG----------DRVK 291
Cdd:cd19528    4 ELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANecQANFISVKGPELLTMWFGeseanvrdifDKAR 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805023975 292 AVASAV-------QAVRHEGGvllitdADALLPAAAEPVASLILSELRTAVATAGVVLIATSARPDQLDARLRSP 359
Cdd:cd19528   84 AAAPCVlffdeldSIAKARGG------NIGDAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRP 152
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 224-364 8.35e-06

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 46.51  E-value: 8.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 224 KLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCDGRRL--VTLDGPEIGALAAGDRVKAVASAVQAVR 301
Cdd:cd19511    4 ELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLnfISVKGPELFSKYVGESERAVREIFQKAR 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 805023975 302 H---------EGGVLLITDADALLPAAAEPVASLILSELRTAVATAGVVLIATSARPDQLDARLRSPELCDR 364
Cdd:cd19511   84 QaapciiffdEIDSLAPRRGQSDSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDK 155
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 238-370 1.10e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 45.99  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 238 LLQTLGAGTNLGVLVSGPAGVGKATLVRAVC-----DGRRLVTLDGPEIGALAAGDR----VKAVASAVQAVRHEGGVLL 308
Cdd:cd00009   10 LREALELPPPKNLLLYGPPGTGKTTLARAIAnelfrPGAPFLYLNASDLLEGLVVAElfghFLVRLLFELAEKAKPGVLF 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 805023975 309 ITDADALLPAAAEPVASLILSELRTAVATAGVVLIATSARPDQLDARLRSPELCDRELGLPL 370
Cdd:cd00009   90 IDEIDSLSRGAQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIPL 151
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 236-366 1.25e-05

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 45.94  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 236 PHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALAAGDRVKAVASAVQAVRHEGGVL------ 307
Cdd:cd19530   19 PDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANesGANFISVKGPELLNKYVGESERAVRQVFQRARASAPCViffdev 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 805023975 308 --LITDADALLPAAAEPVASLILSELRTAVATAGVVLIATSARPDQLDARLRSPELCDREL 366
Cdd:cd19530   99 daLVPKRGDGGSWASERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKTL 159
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 205-415 1.31e-05

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 48.29  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 205 ISSPEIQIEELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVC---------------- 268
Cdd:PRK03992 123 IESPNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAhetnatfirvvgselv 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 269 -----DGRRLVTldgpEIGALAagdRVKAVA-------SAVQAVRHEGGvllitdadalLPAAAEPVASL--ILSELRTA 334
Cdd:PRK03992 203 qkfigEGARLVR----ELFELA---REKAPSiifideiDAIAAKRTDSG----------TSGDREVQRTLmqLLAEMDGF 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 335 VATAGVVLIATSARPDQLDARLRSPELCDRELGLPLPDAATRKSLLEallnpVPT------GDLNLDEIASRTPGFVVAD 408
Cdd:PRK03992 266 DPRGNVKIIAATNRIDILDPAILRPGRFDRIIEVPLPDEEGRLEILK-----IHTrkmnlaDDVDLEELAELTEGASGAD 340


                 ....*..
gi 805023975 409 LAALVRE 415
Cdd:PRK03992 341 LKAICTE 347
PRK04195 PRK04195
replication factor C large subunit; Provisional
 462-574 1.45e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 48.38  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 462 TLDDVGDMAAAKQALTE-AVLWplqhpdtfarLGVEPPRGVLLYGPPGCGKTFVVRALASTGQLSVHAVKGS-----ELM 535
Cdd:PRK04195  12 TLSDVVGNEKAKEQLREwIESW----------LKGKPKKALLLYGPPGVGKTSLAHALANDYGWEVIELNASdqrtaDVI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 805023975 536 DKWVGSSEKaVRELFRRARdsapSLVFLDELDALAPR--RG 574
Cdd:PRK04195  82 ERVAGEAAT-SGSLFGARR----KLILLDEVDGIHGNedRG 117
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 500-620 2.68e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 44.59  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  500 GVLLYGPPGCGKTFVVRALAS-TGQLSVHAVKGS------ELMDKW---VGSSEKAVRELFRRARDSApsLVFLDELDAL 569
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAaLSNRPVFYVQLTrdtteeDLFGRRnidPGGASWVDGPLVRAAREGE--IAVLDEINRA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 805023975  570 APRRGQSFDSGVSDRVVaaLLTELDGID--PLRDVVMLGATNRPDL----IDPALLR 620
Cdd:pfam07728  79 NPDVLNSLLSLLDERRL--LLPDGGELVkaAPDGFRLIATMNPLDRglneLSPALRS 133
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 208-415 3.20e-05

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 47.07  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 208 PEIQIEELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALA 285
Cdd:PTZ00454 140 PDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHhtTATFIRVVGSEFVQKY 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 286 AGDRVKAVASAVQAVRHEGGVLL-------ITDADALLPAAAEPVASLILSELRTAV----ATAGVVLIATSARPDQLDA 354
Cdd:PTZ00454 220 LGEGPRMVRDVFRLARENAPSIIfidevdsIATKRFDAQTGADREVQRILLELLNQMdgfdQTTNVKVIMATNRADTLDP 299

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 805023975 355 RLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTG-DLNLDEIASRTPGFVVADLAALVRE 415
Cdd:PTZ00454 300 ALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKMNLSeEVDLEDFVSRPEKISAADIAAICQE 361
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 391-415 8.96e-05

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 40.21  E-value: 8.96e-05
                          10        20
                  ....*....|....*....|....*
gi 805023975  391 DLNLDEIASRTPGFVVADLAALVRE 415
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCRE 25
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 501-571 3.70e-04

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 43.51  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 501 VLLYGPPGCGKTFVVRALASTGQLSVHAVKGselmdkwVGSSEKAVRELFRRARDSA----PSLVFLDEL--------DA 568
Cdd:COG2256   52 MILWGPPGTGKTTLARLIANATDAEFVALSA-------VTSGVKDIREVIEEARERRaygrRTILFVDEIhrfnkaqqDA 124


                 ...
gi 805023975 569 LAP 571
Cdd:COG2256  125 LLP 127
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 214-368 7.06e-04

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 40.85  E-value: 7.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 214 ELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCD--GRRLVTLDGPEIGALAAGD--- 288
Cdd:cd19518    1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGelKVPFLKISATEIVSGVSGEsee 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 289 RVKAVASavQAVRHEGGVLL------ITDADALLPAAAEP--VASLI--LSELR-TAVATAGVVLIATSARPDQLDARLR 357
Cdd:cd19518   81 KIRELFD--QAISNAPCIVFideidaITPKRESAQREMERriVSQLLtcMDELNnEKTAGGPVLVIGATNRPDSLDPALR 158

                        170
                 ....*....|.
gi 805023975 358 SPELCDRELGL 368
Cdd:cd19518  159 RAGRFDREICL 169
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 501-571 1.21e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 41.99  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 501 VLLYGPPGCGKTFVVRALASTGQLSVHAVKGselmdkwVGSSEKAVRELFRRARDSAPS----LVFLDEL--------DA 568
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSA-------VTSGVKDLREVIEEARQRRSAgrrtILFIDEIhrfnkaqqDA 111


                 ...
gi 805023975 569 LAP 571
Cdd:PRK13342 112 LLP 114
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 213-267 2.34e-03

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 39.63  E-value: 2.34e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 805023975 213 EELKGAQPQAAKLTEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAV 267
Cdd:cd19502    3 EDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAV 57
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 498-576 2.58e-03

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 39.67  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 498 PRGVLLYGPPGCGKTFVVRALASTGQ---LSVHAVKGSELmdKWVGssekavRELFRRARDSAPSLVFLDELDALAPRRG 574
Cdd:cd19498   46 PKNILMIGPTGVGKTEIARRLAKLAGapfIKVEATKFTEV--GYVG------RDVESIIRDLVEGIVFIDEIDKIAKRGG 117


                 ..
gi 805023975 575 QS 576
Cdd:cd19498  118 SS 119
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 225-368 4.91e-03

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 38.26  E-value: 4.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 225 LTEWLKLALDEPHLLqTLGAGTNLGVLVSGPAGVGKATLVRAVCDGRRL--VTLDGPEIGALAAGDRVKAVASAVQAVRH 302
Cdd:cd19527    5 ILDTIQLPLEHPELF-SSGLRKRSGILLYGPPGTGKTLLAKAIATECSLnfLSVKGPELINMYIGESEANVREVFQKARD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 303 -----------------------EGGVLlitdadallpaaaEPVASLILSELR-TAVATAGVVLIATSARPDQLDARLRS 358
Cdd:cd19527   84 akpcviffdeldslapsrgnsgdSGGVM-------------DRVVSQLLAELDgMSSSGQDVFVIGATNRPDLLDPALLR 150

                        170
                 ....*....|
gi 805023975 359 PELCDRELGL 368
Cdd:cd19527  151 PGRFDKLLYL 160
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 501-519 7.67e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 39.37  E-value: 7.67e-03
                         10
                 ....*....|....*....
gi 805023975 501 VLLYGPPGCGKTFVVRALA 519
Cdd:COG1401  224 VILAGPPGTGKTYLARRLA 242
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 501-571 8.55e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 37.95  E-value: 8.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975  501 VLLYGPPGCGKTFVVRALASTGQLSVHAVK---GSELMDKW-----VGSSEKAVR-----ELFRRARDSAPSLVFLDELD 567
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELLFGDERALIridMSEYMEEHsvsrlIGAPPGYVGyeeggQLTEAVRRKPYSIVLIDEIE 85


                  ....
gi 805023975  568 ALAP 571
Cdd:pfam07724  86 KAHP 89
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 205-415 9.55e-03

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 38.98  E-value: 9.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 205 ISSPEIQIEELKgaqpqaakltEWLKLALDEPHLLQTLGAGTNLGVLVSGPAGVGKATLVRAVCDGR-----RLVtldGP 279
Cdd:PTZ00361 185 IGGLEQQIQEIK----------EAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETsatflRVV---GS 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 280 EIGALAAGDRVKAVASAVQ-AVRHEGGVLLI-------TDADALLPAAAEPVASLILsELRTAV----ATAGVVLIATSA 347
Cdd:PTZ00361 252 ELIQKYLGDGPKLVRELFRvAEENAPSIVFIdeidaigTKRYDATSGGEKEIQRTML-ELLNQLdgfdSRGDVKVIMATN 330

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805023975 348 RPDQLDARLRSPELCDRELGLPLPDAATRKSLLEALLNPVPTG-DLNLDEIASRTPGFVVADLAALVRE 415
Cdd:PTZ00361 331 RIESLDPALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAeDVDLEEFIMAKDELSGADIKAICTE 399
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 491-567 9.77e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 37.93  E-value: 9.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805023975 491 ARLGVEPPR---GVLLY-GPPGCGKTFVVRALAST---GQLSVHAVKGSELMDK------------WVGSSEKAVreLFR 551
Cdd:cd19499   30 ARAGLSDPNrpiGSFLFlGPTGVGKTELAKALAELlfgDEDNLIRIDMSEYMEKhsvsrligappgYVGYTEGGQ--LTE 107

                         90
                 ....*....|....*.
gi 805023975 552 RARDSAPSLVFLDELD 567
Cdd:cd19499  108 AVRRKPYSVVLLDEIE 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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