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Conserved domains on  [gi|804913287|emb|CRA91792|]
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secreted effector protein [Salmonella enterica subsp. enterica serovar Typhi]

Protein Classification

SPI-2 type III secretion system effector E3 ubiquitin transferase SspH2( domain architecture ID 11487764)

SPI-2 type III secretion system effector E3 ubiquitin transferase SspH2 is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway

CATH:  3.80.10.10
EC:  2.3.2.27
Gene Ontology:  GO:0016567|GO:0004842|GO:0030254|GO:0061630
SCOP:  4003209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
1-788 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


:

Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 1600.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAY 80
Cdd:PRK15387   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160
Cdd:PRK15387  81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAAVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240
Cdd:PRK15387 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320
Cdd:PRK15387 241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400
Cdd:PRK15387 321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIR 480
Cdd:PRK15387 401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIR 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560
Cdd:PRK15387 481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640
Cdd:PRK15387 561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 641 EIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPKRVNALRE 720
Cdd:PRK15387 641 EIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALRE 720

                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 804913287 721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
Cdd:PRK15387 721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
 
Name Accession Description Interval E-value
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
1-788 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 1600.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAY 80
Cdd:PRK15387   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160
Cdd:PRK15387  81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAAVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240
Cdd:PRK15387 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320
Cdd:PRK15387 241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400
Cdd:PRK15387 321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIR 480
Cdd:PRK15387 401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIR 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560
Cdd:PRK15387 481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640
Cdd:PRK15387 561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 641 EIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPKRVNALRE 720
Cdd:PRK15387 641 EIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALRE 720

                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 804913287 721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
Cdd:PRK15387 721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 502-714 9.40e-85

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 268.05  E-value: 9.40e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  502 WLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDA-GFKAQISSWLAQLAEDEALRANTFAMATEATSSC 580
Cdd:pfam14496   1 WLQACAELRPERLAAWRALEAEEGAAAFFRFLARLRETASFRNDAeALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  581 EDRVTFFLHQMKNVQLVHNAEKGQYDND-LAALVATGREMFRLGKLEQIAREKVRTLALVDEIEVWLAYQNKLKKSLGLT 659
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNrLAALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 804913287  660 SVTSEMRFFDVSGVTVTDLQDAELQVKAAE-KSEFREWILQWGPLHRVLERKAPKR 714
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
222-517 2.50e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 2.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 222 AHITTLVIPDNNLTSLPAL---PPELRTLEVSGNQLTSLPvlppgllelsifsNPLTHLPALPSglckLWIFGNQLTSLP 298
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLP-------------EPLGNLTNLKS----LDLSNNQLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 299 V----LPpGLQELSVSDNQLASLPALPSELC---KLWAYNNQLTSLP----TLPSgLQELSVSDNQLASLPTLP--SELY 365
Cdd:COG4886  176 EelgnLT-NLKELDLSNNQITDLPEPLGNLTnleELDLSGNQLTDLPeplaNLTN-LETLDLSNNQLTDLPELGnlTNLE 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 366 KLWAYNNRLTSLPALP--SGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIH 443
Cdd:COG4886  254 ELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 804913287 444 LSSETTVNLEGNPLSERTLQALREITSAPGYS--GPIIRFDMAGASAPRETRALHLAAADWLVPAREGEPAPADRW 517
Cdd:COG4886  334 LVTLTTLALSLSLLALLTLLLLLNLLSLLLTLllTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 284-458 6.27e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 6.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 284 LCKLWIFGNQLTSLPVLP--PGLQELSVSDNQLASLP---ALPSeLCKLWAYNNQLTSLPTL--PSGLQELSVSDNQLAS 356
Cdd:cd21340   26 LKVLYLYDNKITKIENLEflTNLTHLYLQNNQIEKIEnleNLVN-LKKLYLGGNRISVVEGLenLTNLEELHIENQRLPP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 357 lptlpselyklwayNNRLT----SLPALPSGLKELIVSGNRLTSLPVLP--SELKELMVSGNRLTSLpmlpsgllslsvy 430
Cdd:cd21340  105 --------------GEKLTfdprSLAALSNSLRVLNISGNNIDSLEPLAplRNLEQLDASNNQISDL------------- 157

                        170       180
                 ....*....|....*....|....*...
gi 804913287 431 rNQLTRLPESLIHLsseTTVNLEGNPLS 458
Cdd:cd21340  158 -EELLDLLSSWPSL---RELDLTGNPVC 181
 
Name Accession Description Interval E-value
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
1-788 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 1600.20  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAY 80
Cdd:PRK15387   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160
Cdd:PRK15387  81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAAVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240
Cdd:PRK15387 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320
Cdd:PRK15387 241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400
Cdd:PRK15387 321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIR 480
Cdd:PRK15387 401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIR 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560
Cdd:PRK15387 481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640
Cdd:PRK15387 561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 641 EIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPKRVNALRE 720
Cdd:PRK15387 641 EIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALRE 720

                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 804913287 721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
Cdd:PRK15387 721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
12-785 0e+00

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 650.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  12 ATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAYAGWEESIHSGQ 91
Cdd:PRK15370   9 STARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAYADNIQYSR 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  92 HGENYFCILDEDSQEILSVTLDDAGnYTVNCQGYSETHrlTLDTAqGEEgtghAEGASGTfrtsflpattapQTPAEYDA 171
Cdd:PRK15370  89 GGADQYCILSENSQEILSIVFNTEG-YTVEGGGKSVTY--TRVTE-SEQ----ASSASGS------------KDAVNYEL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 172 VWSAWRRAAPAEESRGRAAAVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPA-LPPELRTLEVS 250
Cdd:PRK15370 149 IWSEWVKEAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPEnLQGNIKTLYAN 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 251 GNQLTSLP-VLPPGLLELSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLP-VLPPGLQELSVSDNQLASLPA-LPSELCK 326
Cdd:PRK15370 229 SNQLTSIPaTLPDTIQEMELSINRITELPErLPSALQSLDLFHNKISCLPeNLPEELRYLSVYDNSIRTLPAhLPSGITH 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 327 LWAYNNQLTSLP-TLPSGLQELSVSDNQLASLPTlpselyklwaynnrltslpALPSGLKELIVSGNRLTSLP-VLPSEL 404
Cdd:PRK15370 309 LNVQSNSLTALPeTLPPGLKTLEAGENALTSLPA-------------------SLPPELQVLDVSKNQITVLPeTLPPTI 369

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 405 KELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPESLIHLSSE----TTVNLEGNPLSERTLQALREITSAPGYSGPII 479
Cdd:PRK15370 370 TTLDVSRNALTNLPEnLPAALQIMQASRNNLVRLPESLPHFRGEgpqpTRIIVEYNPFSERTIQNMQRLMSSVGYQGPRV 449

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 480 RFDMAGASAPRETRALHLAAADWLVPAREGEpapADRWHMFGQEDNADAFSLFLDRLSETENfIKDAGFKAQISSWLAQL 559
Cdd:PRK15370 450 LFAMGDFSIVRVTRPLHQAVQGWLTNLEEED---VNQWRAFETEVNAAAFSMFLDRLSDTQN-TRHPDFKEQVSAWLMRL 525

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 560 AEDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALV 639
Cdd:PRK15370 526 AEDSALRETAFIIAMDATISCEDRVTLAYHQMQEATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFI 605

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 640 DEIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPKRVNALR 719
Cdd:PRK15370 606 DEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGITESDLDEAEIRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMM 685

                        730       740       750       760       770       780       790
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 720 EKQIsDYEET--YRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGL--RPLVEEMLGSYLNVQW 785
Cdd:PRK15370 686 AKRA-ECIETdeYQSRVNAELEALGIAGDPDAERMAGMRIMEEINQTLFTEImeNILLKKEVSSLMSAYW 754
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 502-714 9.40e-85

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 268.05  E-value: 9.40e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  502 WLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDA-GFKAQISSWLAQLAEDEALRANTFAMATEATSSC 580
Cdd:pfam14496   1 WLQACAELRPERLAAWRALEAEEGAAAFFRFLARLRETASFRNDAeALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  581 EDRVTFFLHQMKNVQLVHNAEKGQYDND-LAALVATGREMFRLGKLEQIAREKVRTLALVDEIEVWLAYQNKLKKSLGLT 659
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNrLAALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 804913287  660 SVTSEMRFFDVSGVTVTDLQDAELQVKAAE-KSEFREWILQWGPLHRVLERKAPKR 714
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
PRK15372 PRK15372
type III secretion system effector SseI;
31-142 1.42e-67

type III secretion system effector SseI;


Pssm-ID: 185270  Cd Length: 292  Bit Score: 225.39  E-value: 1.42e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  31 MSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAYAGWEESIHSGQHGENYFCILDEDSQEILSV 110
Cdd:PRK15372   1 MSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTLAYDGWEENIHSGLHGENYFCILDEDSQEILSV 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 804913287 111 TLDDAGNYTVNCQGYSETHRLTLDTAQGEEGT 142
Cdd:PRK15372  81 TLDDVGNYTVNCQGYSETHHLTMATEPGVERT 112
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
222-517 2.50e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 2.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 222 AHITTLVIPDNNLTSLPAL---PPELRTLEVSGNQLTSLPvlppgllelsifsNPLTHLPALPSglckLWIFGNQLTSLP 298
Cdd:COG4886  113 TNLESLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLP-------------EPLGNLTNLKS----LDLSNNQLTDLP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 299 V----LPpGLQELSVSDNQLASLPALPSELC---KLWAYNNQLTSLP----TLPSgLQELSVSDNQLASLPTLP--SELY 365
Cdd:COG4886  176 EelgnLT-NLKELDLSNNQITDLPEPLGNLTnleELDLSGNQLTDLPeplaNLTN-LETLDLSNNQLTDLPELGnlTNLE 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 366 KLWAYNNRLTSLPALP--SGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIH 443
Cdd:COG4886  254 ELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 804913287 444 LSSETTVNLEGNPLSERTLQALREITSAPGYS--GPIIRFDMAGASAPRETRALHLAAADWLVPAREGEPAPADRW 517
Cdd:COG4886  334 LVTLTTLALSLSLLALLTLLLLLNLLSLLLTLllTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
205-469 5.65e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 5.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 205 VLNVGESGLTTLPDCLPA--HITTLVIPDNNLTSLPA-LP--PELRTLEVSGNQLTSLPV----LPpGLLELSIFSNPLT 275
Cdd:COG4886  117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEpLGnlTNLKSLDLSNNQLTDLPEelgnLT-NLKELDLSNNQIT 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 276 HLPALPSGLC---KLWIFGNQLTSLPV-LP--PGLQELSVSDNQLASLPALP--SELCKLWAYNNQLTSLPTLP--SGLQ 345
Cdd:COG4886  196 DLPEPLGNLTnleELDLSGNQLTDLPEpLAnlTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQLTDLPPLAnlTNLK 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 346 ELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLL 425
Cdd:COG4886  276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 804913287 426 SLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREIT 469
Cdd:COG4886  356 LNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
207-459 1.15e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 1.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 207 NVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCK 286
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 287 LWIFGNQLTSLPVLPPGLQELSVSDNQ-LASLPALPSelckLWAYNNQLTSLPT----LPSgLQELSVSDNQLASLPT-- 359
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLES----LDLSGNQLTDLPEelanLTN-LKELDLSNNQLTDLPEpl 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 360 --LPSeLYKLWAYNNRLTSLPA----LPSgLKELIVSGNRLTSLPvlpSELKELmvsgnrltslpmlpSGLLSLSVYRNQ 433
Cdd:COG4886  156 gnLTN-LKSLDLSNNQLTDLPEelgnLTN-LKELDLSNNQITDLP---EPLGNL--------------TNLEELDLSGNQ 216

                        250       260
                 ....*....|....*....|....*.
gi 804913287 434 LTRLPESLIHLSSETTVNLEGNPLSE 459
Cdd:COG4886  217 LTDLPEPLANLTNLETLDLSNNQLTD 242
PRK15381 PRK15381
type III secretion system effector;
1-113 7.84e-14

type III secretion system effector;


Pssm-ID: 185279  Cd Length: 408  Bit Score: 74.31  E-value: 7.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICH-PPAGTTREDVINRFELLRTLA 79
Cdd:PRK15381   1 MPLSVGQGYFTSSISSEKFNAIKESARLPELSLWEKIKAYFFTTHHAEALECIFNLYHhQELNLTPVQVRGAYIKLRALA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 804913287  80 YAGWEES--IHSGQHGENyFCILDEDSQEILSVTLD 113
Cdd:PRK15381  81 SQGCKEQfiIESQEHADK-LIIKDDNGENILSIEVE 115
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 284-458 6.27e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 6.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 284 LCKLWIFGNQLTSLPVLP--PGLQELSVSDNQLASLP---ALPSeLCKLWAYNNQLTSLPTL--PSGLQELSVSDNQLAS 356
Cdd:cd21340   26 LKVLYLYDNKITKIENLEflTNLTHLYLQNNQIEKIEnleNLVN-LKKLYLGGNRISVVEGLenLTNLEELHIENQRLPP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 357 lptlpselyklwayNNRLT----SLPALPSGLKELIVSGNRLTSLPVLP--SELKELMVSGNRLTSLpmlpsgllslsvy 430
Cdd:cd21340  105 --------------GEKLTfdprSLAALSNSLRVLNISGNNIDSLEPLAplRNLEQLDASNNQISDL------------- 157

                        170       180
                 ....*....|....*....|....*...
gi 804913287 431 rNQLTRLPESLIHLsseTTVNLEGNPLS 458
Cdd:cd21340  158 -EELLDLLSSWPSL---RELDLTGNPVC 181
PRK15386 PRK15386
type III secretion effector GogB;
347-429 1.53e-07

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 54.49  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 347 LSVSDNQLASLPTLPSELYKLWAYN-NRLTSLP-ALPSGLKELIVSgnRLTSLPVLPSELKELMVSGNRLTSLPMLPSGL 424
Cdd:PRK15386  57 LYIKDCDIESLPVLPNELTEITIENcNNLTTLPgSIPEGLEKLTVC--HCPEISGLPESVRSLEIKGSATDSIKNVPNGL 134


                 ....*
gi 804913287 425 LSLSV 429
Cdd:PRK15386 135 TSLSI 139
PRK15386 PRK15386
type III secretion effector GogB;
227-353 6.90e-07

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 52.56  E-value: 6.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 227 LVIPDNNLTSLPALPPELRTLEVSG-NQLTSLP-VLPPGLLELSIFSNPltHLPALPSGLCKLWIFGNQLTSLPVLPPGL 304
Cdd:PRK15386  57 LYIKDCDIESLPVLPNELTEITIENcNNLTTLPgSIPEGLEKLTVCHCP--EISGLPESVRSLEIKGSATDSIKNVPNGL 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 804913287 305 QELSVSD----NQLASLPALPSELCKLWAYNNQLTSLPT-LPSGLQELSVSDNQ 353
Cdd:PRK15386 135 TSLSINSynpeNQARIDNLISPSLKTLSLTGCSNIILPEkLPESLQSITLHIEQ 188
PRK15386 PRK15386
type III secretion effector GogB;
287-469 3.38e-05

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 47.17  E-value: 3.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 287 LWIFGNQLTSLPVLPPGLQELSVSD-NQLASLP-ALPSELCKLWAynNQLTSLPTLPSGLQELSVSDNQLASLPTLPSEL 364
Cdd:PRK15386  57 LYIKDCDIESLPVLPNELTEITIENcNNLTTLPgSIPEGLEKLTV--CHCPEISGLPESVRSLEIKGSATDSIKNVPNGL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 365 YKLwaynnrltSLpalpsglkELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPESLIH 443
Cdd:PRK15386 135 TSL--------SI--------NSYNPENQARIDNLISPSLKTLSLTGCSNIILPEkLPESLQSITLHIEQKTTWNISFEG 198

                        170       180
                 ....*....|....*....|....*.
gi 804913287 444 LSSETTVNLEGNPLSERTLQALREIT 469
Cdd:PRK15386 199 FPDGLDIDLQNSVLLSPDVFKDKNIT 224
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 301-472 3.62e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 3.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 301 PPGLQELSVSDNQLASLP-ALPSELCKLwaynnqltslpTLPSGLQELSVSDNQL--ASLPTLPS--------ELYKLwa 369
Cdd:cd00116   50 QPSLKELCLSLNETGRIPrGLQSLLQGL-----------TKGCGLQELDLSDNALgpDGCGVLESllrssslqELKLN-- 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 370 yNNRL---------TSLPALPSGLKELIVSGNRLTS---------LPVLPSeLKELMVSGNRLT---------SLPMLpS 422
Cdd:cd00116  117 -NNGLgdrglrllaKGLKDLPPALEKLVLGRNRLEGascealakaLRANRD-LKELNLANNGIGdagiralaeGLKAN-C 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 804913287 423 GLLSLSVYRNQLTR-----LPESLIHLSSETTVNLEGNPLSERTLQALREITSAP 472
Cdd:cd00116  194 NLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGAAALASALLSP 248
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
206-382 3.84e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 3.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 206 LNVGESGLTTLPD--CLPaHITTLVIPDNNLTSLPALP--PELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALP 281
Cdd:COG4886  233 LDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 282 SGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLP 361
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391

                        170       180
                 ....*....|....*....|.
gi 804913287 362 SELYKLWAYNNRLTSLPALPS 382
Cdd:COG4886  392 LLLTTTAGVLLLTLALLDAVN 412
PRK15386 PRK15386
type III secretion effector GogB;
213-313 5.34e-05

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 46.40  E-value: 5.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 213 LTTLPDCLPAHITTLVIpdNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFS-NPLTHL---PALPSGLCKLW 288
Cdd:PRK15386  85 LTTLPGSIPEGLEKLTV--CHCPEISGLPESVRSLEIKGSATDSIKNVPNGLTSLSINSyNPENQAridNLISPSLKTLS 162

                         90       100
                 ....*....|....*....|....*.
gi 804913287 289 IFGNQLTSLPV-LPPGLQELSVSDNQ 313
Cdd:PRK15386 163 LTGCSNIILPEkLPESLQSITLHIEQ 188
LRR_8 pfam13855
Leucine rich repeat;
402-457 5.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 5.40e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 804913287  402 SELKELMVSGNRLTSLPM-----LPSgLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPL 457
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafkgLSN-LKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
sifA PRK09498
type III secretion system effector SifA;
1-111 5.04e-04

type III secretion system effector SifA;


Pssm-ID: 181911  Cd Length: 336  Bit Score: 43.08  E-value: 5.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287   1 MPFHIGSGCLPATI--SNRRIYRIAWSDTppemsSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTL 78
Cdd:PRK09498   1 MPITIGNGFLKSEIltNSPRNTKEAWWKV-----LWEKIKDFFFSTGKAKADRCLHEMLFADRAPTRERLTEIFFELKEL 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 804913287  79 AYAGWEESIHSGQHGEN----YFCILDEDSQ-EILSVT 111
Cdd:PRK09498  76 ACASQRDRFQVHNPHENdatiILRIMDQNEEnELLRIT 113
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 277-395 5.76e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 277 LPALPSGLCKLWIFGNQLTSLP------VLP--PGLQELSVSDNQL------ASLPALP--SELCKLWAYNNQLTS---- 336
Cdd:cd00116  132 LKDLPPALEKLVLGRNRLEGAScealakALRanRDLKELNLANNGIgdagirALAEGLKanCNLEVLDLNNNGLTDegas 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287 337 -----LPTLPSgLQELSVSDNQLAS---------LPTLPSELYKLWAYNNRLT---------SLPALPSgLKELIVSGNR 393
Cdd:cd00116  212 alaetLASLKS-LEVLNLGDNNLTDagaaalasaLLSPNISLLTLSLSCNDITddgakdlaeVLAEKES-LLELDLRGNK 289


                 ..
gi 804913287 394 LT 395
Cdd:cd00116  290 FG 291
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 260-456 1.43e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.17  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  260 LPPGLLELSIFSNPLTHLPA--LPSGLCKLWIFGNQLTSL--PVLP-PGLQELSV--SDNqLASLP--ALPSELCKLwaY 330
Cdd:PLN03210  587 LPPKLRLLRWDKYPLRCMPSnfRPENLVKLQMQGSKLEKLwdGVHSlTGLRNIDLrgSKN-LKEIPdlSMATNLETL--K 663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  331 NNQLTSLPTLPSGLQELsvsdNQLAS--------LPTLPS--ELYKLWAYN----NRLTSLPALPSGLKELIVSGnrlTS 396
Cdd:PLN03210  664 LSDCSSLVELPSSIQYL----NKLEDldmsrcenLEILPTgiNLKSLYRLNlsgcSRLKSFPDISTNISWLDLDE---TA 736

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804913287  397 LPVLPSELK-----EL----MVSGNR------LTSL-PMLPSGLLSLSVYRNQ-LTRLPES------LIHLSSETTVNLE 453
Cdd:PLN03210  737 IEEFPSNLRlenldELilceMKSEKLwervqpLTPLmTMLSPSLTRLFLSDIPsLVELPSSiqnlhkLEHLEIENCINLE 816


                  ...
gi 804913287  454 GNP 456
Cdd:PLN03210  817 TLP 819
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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