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Conserved domains on  [gi|804741487|emb|CQZ43421|]
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N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Salmonella enterica subsp. enterica serovar Typhi]

Protein Classification

HemK/PrmC family methyltransferase( domain architecture ID 11483836)

HemK/PrmC family methyltransferase is a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; such as peptide chain release factor N(5)-glutamine methyltransferase that methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0003676|GO:0032259|GO:1904047
PubMed:  12741815|12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-275 5.09e-136

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


:

Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 384.90  E-value: 5.09e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   1 MDFQHWLHEAVNQLRDsdsPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSL 80
Cdd:PRK09328   2 MTIAEALREATARLAS---PRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  81 PLFVSPATLIPRPDTECLVEQALARLP-VKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIR 159
Cdd:PRK09328  79 DFKVSPGVLIPRPETEELVEWALEALLlKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 160 NVRILQSCWFSALSGQQFDMIVSNPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNARQMLTPGGFLLLEH 238
Cdd:PRK09328 159 RVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEI 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 804741487 239 GWRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGRF 275
Cdd:PRK09328 239 GYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-275 5.09e-136

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 384.90  E-value: 5.09e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   1 MDFQHWLHEAVNQLRDsdsPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSL 80
Cdd:PRK09328   2 MTIAEALREATARLAS---PRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  81 PLFVSPATLIPRPDTECLVEQALARLP-VKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIR 159
Cdd:PRK09328  79 DFKVSPGVLIPRPETEELVEWALEALLlKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 160 NVRILQSCWFSALSGQQFDMIVSNPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNARQMLTPGGFLLLEH 238
Cdd:PRK09328 159 RVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEI 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 804741487 239 GWRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGRF 275
Cdd:PRK09328 239 GYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-274 2.29e-128

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 365.63  E-value: 2.29e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   1 MDFQHWLHEAVNQLRD--SDSPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFW 78
Cdd:COG2890    1 MTIRELLRWAAARLAAagVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  79 SLPLFVSPATLIPRPDTECLVEQALARLP-VKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLA 157
Cdd:COG2890   81 GLEFKVDPGVLIPRPETEELVELALALLPaGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 158 IRN-VRILQSCWFSALSG-QQFDMIVSNPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNARQMLTPGGFL 234
Cdd:COG2890  161 LEDrVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 804741487 235 LLEHGWRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGR 274
Cdd:COG2890  241 LLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVAR 280
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 23-272 6.41e-128

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 363.33  E-value: 6.41e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   23 DAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSLPLFVSPATLIPRPDTECLVEQA 102
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  103 LARLPVKTcRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGQQFDMIVS 182
Cdd:TIGR03534  81 LERLKKGP-RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  183 NPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNARQMLTPGGFLLLEHGWRQGEAVRAAFRRSGYTDVETC 261
Cdd:TIGR03534 160 NPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETR 239

                         250
                  ....*....|.
gi 804741487  262 RDYGGNERVAC 272
Cdd:TIGR03534 240 KDLAGKDRVVL 250
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 112-236 8.03e-18

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 78.79  E-value: 8.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  112 RILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGQQFDMIVSNPPYIDAQD 191
Cdd:pfam05175  34 KVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVEDGKFDLIISNPPFHAGLA 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 804741487  192 PHLSegdvrfeprsalVADEngmadlthIIDNARQMLTPGGFLLL 236
Cdd:pfam05175 114 TTYN------------VAQR--------FIADAKRHLRPGGELWI 138
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 112-237 1.88e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 73.23  E-value: 1.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 112 RILDLGTGTGAIALALAcERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSAL--SGQQFDMIVSNPPYIDa 189
Cdd:cd02440    1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPpeADESFDVIISDPPLHH- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 804741487 190 qdphlsegdvrfeprsalvadenGMADLTHIIDNARQMLTPGGFLLLE 237
Cdd:cd02440   79 -----------------------LVEDLARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 1-275 5.09e-136

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 384.90  E-value: 5.09e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   1 MDFQHWLHEAVNQLRDsdsPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSL 80
Cdd:PRK09328   2 MTIAEALREATARLAS---PRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  81 PLFVSPATLIPRPDTECLVEQALARLP-VKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIR 159
Cdd:PRK09328  79 DFKVSPGVLIPRPETEELVEWALEALLlKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 160 NVRILQSCWFSALSGQQFDMIVSNPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNARQMLTPGGFLLLEH 238
Cdd:PRK09328 159 RVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEI 238

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 804741487 239 GWRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGRF 275
Cdd:PRK09328 239 GYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 1-274 2.29e-128

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 365.63  E-value: 2.29e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   1 MDFQHWLHEAVNQLRD--SDSPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFW 78
Cdd:COG2890    1 MTIRELLRWAAARLAAagVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  79 SLPLFVSPATLIPRPDTECLVEQALARLP-VKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLA 157
Cdd:COG2890   81 GLEFKVDPGVLIPRPETEELVELALALLPaGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 158 IRN-VRILQSCWFSALSG-QQFDMIVSNPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNARQMLTPGGFL 234
Cdd:COG2890  161 LEDrVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 804741487 235 LLEHGWRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGR 274
Cdd:COG2890  241 LLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVAR 280
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 23-272 6.41e-128

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 363.33  E-value: 6.41e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   23 DAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSLPLFVSPATLIPRPDTECLVEQA 102
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  103 LARLPVKTcRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGQQFDMIVS 182
Cdd:TIGR03534  81 LERLKKGP-RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  183 NPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNARQMLTPGGFLLLEHGWRQGEAVRAAFRRSGYTDVETC 261
Cdd:TIGR03534 160 NPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETR 239

                         250
                  ....*....|.
gi 804741487  262 RDYGGNERVAC 272
Cdd:TIGR03534 240 KDLAGKDRVVL 250
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 1-274 5.06e-118

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 339.71  E-value: 5.06e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487    1 MDFQHWLHEAVNQLRDSDSPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSL 80
Cdd:TIGR00536   4 QEFLRWASSALSRAIARENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKGVPVAYLLGSKEFYGL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   81 PLFVSPATLIPRPDTECLVEQALARLPVK--TCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAI 158
Cdd:TIGR00536  84 EFFVNEHVLIPRPETEELVEKALASLISQppILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  159 -RNVRILQSCWFSALSGQQFDMIVSNPPYIDAQDPHLSEGDVRFEPRSALVADENGMADLTHIIDNARQMLTPGGFLLLE 237
Cdd:TIGR00536 164 eHRVEFIQSNLFEPLAGQKIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYLKPNGFLVCE 243

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 804741487  238 HG-WRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGR 274
Cdd:TIGR00536 244 IGnWQQKSLKELLRIKFTWYDVENGRDLNGKERVVLGF 281
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 1-275 1.32e-62

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 203.00  E-value: 1.32e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   1 MDFQHWLheAVNQLrdsdsPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSL 80
Cdd:PRK14966 151 MTFDEWL--GLSKL-----PKNEARMLLQYASEYTRVQLLTRGGEEMPDEVRQRADRLAQRRLNGEPVAYILGVREFYGR 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  81 PLFVSPATLIPRPDTECLVEQALARLPvKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRn 160
Cdd:PRK14966 224 RFAVNPNVLIPRPETEHLVEAVLARLP-ENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAADLGAR- 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 161 VRILQSCWFSA--LSGQQFDMIVSNPPYIDAQDPHLSEGDVRFEPRSALVADENGMADLTHIIDNARQMLTPGGFLLLEH 238
Cdd:PRK14966 302 VEFAHGSWFDTdmPSEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEH 381

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 804741487 239 GWRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGRF 275
Cdd:PRK14966 382 GFDQGAAVRGVLAENGFSGVETLPDLAGLDRVTLGKY 418
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 18-270 7.62e-50

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 171.59  E-value: 7.62e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  18 DSPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSLPLFVSPATLIPRPDTEC 97
Cdd:PRK01544  22 SSPQLEARILLQHVINKPIEYLLINLDEQLNEAEIEAFEKLLERRLKHEPIAYITGVKEFYSREFIVNKHVLIPRSDTEV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  98 LVEQAL-------------------------ARLPVKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRN 152
Cdd:PRK01544 102 LVDVVFqchsresgnpekkqlnpcfrgndisSNCNDKFLNILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSN 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 153 A-EHLAIRNVRILQSCWFSALSGQQFDMIVSNPPYID-AQDPHLSEGDVRFEPRSALVADENGMADLTHIIDNARQMLTP 230
Cdd:PRK01544 182 AiKYEVTDRIQIIHSNWFENIEKQKFDFIVSNPPYIShSEKSEMAIETINYEPSIALFAEEDGLQAYFIIAENAKQFLKP 261

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 804741487 231 GGFLLLEHGWRQGEAVRAAFRRSGYTDVETCRDYGGNERV 270
Cdd:PRK01544 262 NGKIILEIGFKQEEAVTQIFLDHGYNIESVYKDLQGHSRV 301
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 67-239 9.70e-38

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 134.18  E-value: 9.70e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   67 PIAYLTGLREFWSLPLFVSPATLIPRPDTECLVEQALARL----PVKtcRILDLGTGTGAIALALACERPDCEVTAVDRM 142
Cdd:TIGR03533  77 PVAYLTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWlepePVK--RILDLCTGSGCIAIACAYAFPEAEVDAVDIS 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  143 PDAVALAIRN-AEHLAIRNVRILQSCWFSALSGQQFDMIVSNPPYIDAQD----PHlsegDVRFEPRSALVADENGMaDL 217
Cdd:TIGR03533 155 PDALAVAEINiERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDmadlPA----EYHHEPELALASGEDGL-DL 229

                         170       180
                  ....*....|....*....|...
gi 804741487  218 TH-IIDNARQMLTPGGFLLLEHG 239
Cdd:TIGR03533 230 VRrILAEAADHLNENGVLVVEVG 252
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 112-254 9.58e-25

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 98.68  E-value: 9.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 112 RILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRN-VRILQSC---WFSALSGQQFDMIVSNPPYI 187
Cdd:COG4123   40 RVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDlkeFAAELPPGSFDLVVSNPPYF 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 804741487 188 DAQDPHLSEGDVRfepRSALVADENGMADLthiIDNARQMLTPGGFLLLEHGWRQGEAVRAAFRRSG 254
Cdd:COG4123  120 KAGSGRKSPDEAR---AIARHEDALTLEDL---IRAAARLLKPGGRFALIHPAERLAEILAALRKYG 180
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 112-236 4.00e-24

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 96.03  E-value: 4.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 112 RILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGQQFDMIVSNPPYidaqd 191
Cdd:COG2813   52 RVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSNPPF----- 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 804741487 192 pHlsegdvrfeprsalvADENGMADLTH-IIDNARQMLTPGGFLLL 236
Cdd:COG2813  127 -H---------------AGRAVDKEVAHaLIADAARHLRPGGELWL 156
PrmC_rel_meth TIGR03704
putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein ...
 61-263 4.11e-24

putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274733 [Multi-domain]  Cd Length: 251  Bit Score: 97.55  E-value: 4.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   61 RRKQGEPIAYLTGLREFWSLPLFVSPATLIPRPDTECLVEQALARLPVKTCR--ILDLGTGTGAIALALACERPDCEVTA 138
Cdd:TIGR03704  36 RRVAGLPLEHVLGWAEFCGLRIAVDPGVFVPRRRTEFLVDEAAALARPRSGTlvVVDLCCGSGAVGAALAAALDGIELHA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  139 VDRMPDAVALAIRNaehLAIRNVRILQSCWFSALSGQ---QFDMIVSNPPYIDAQDPHLSEGDVRF-EPRSALVADENGM 214
Cdd:TIGR03704 116 ADIDPAAVRCARRN---LADAGGTVHEGDLYDALPTAlrgRVDILAANAPYVPTDAIALMPPEARDhEPRVALDGGADGL 192

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 804741487  215 ADLTHIIDNARQMLTPGGFLLLEHGWRQGEAVRAAFRRSGY-TDVETCRD 263
Cdd:TIGR03704 193 DVLRRVAAGAPDWLAPGGHLLVETSERQAPLAVEAFARAGLiARVASSEE 242
PRK14967 PRK14967
putative methyltransferase; Provisional
 91-238 1.62e-21

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 89.73  E-value: 1.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  91 PRPDTECLVEQALARLPVKTCRILDLGTGTGAIALAlACERPDCEVTAVDRMPDAVALAIRNAEhLAIRNVRILQSCWFS 170
Cdd:PRK14967  18 PQEDTQLLADALAAEGLGPGRRVLDLCTGSGALAVA-AAAAGAGSVTAVDISRRAVRSARLNAL-LAGVDVDVRRGDWAR 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 804741487 171 ALSGQQFDMIVSNPPYIdaqdPHLSEGDVRFEPRSALVADENGMADLTHIIDNARQMLTPGGFLLLEH 238
Cdd:PRK14967  96 AVEFRPFDVVVSNPPYV----PAPPDAPPSRGPARAWDAGPDGRAVLDRLCDAAPALLAPGGSLLLVQ 159
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 112-236 8.03e-18

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 78.79  E-value: 8.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  112 RILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGQQFDMIVSNPPYIDAQD 191
Cdd:pfam05175  34 KVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVEDGKFDLIISNPPFHAGLA 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 804741487  192 PHLSegdvrfeprsalVADEngmadlthIIDNARQMLTPGGFLLL 236
Cdd:pfam05175 114 TTYN------------VAQR--------FIADAKRHLRPGGELWI 138
PRK14968 PRK14968
putative methyltransferase; Provisional
 91-236 8.19e-17

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 76.48  E-value: 8.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  91 PRPDTECLVEQALARlpvKTCRILDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLAIRN--VRILQSCW 168
Cdd:PRK14968   8 PAEDSFLLAENAVDK---KGDRVLEVGTGSGIVAIVAA--KNGKKVVGVDINPYAVECAKCNAKLNNIRNngVEVIRSDL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 804741487 169 FSALSGQQFDMIVSNPPYIdaqdPHLSEGDVRFEPRSALVADENGMADLTHIIDNARQMLTPGGFLLL 236
Cdd:PRK14968  83 FEPFRGDKFDVILFNPPYL----PTEEEEEWDDWLNYALSGGKDGREVIDRFLDEVGRYLKPGGRILL 146
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 112-237 1.88e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 73.23  E-value: 1.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 112 RILDLGTGTGAIALALAcERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSAL--SGQQFDMIVSNPPYIDa 189
Cdd:cd02440    1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPpeADESFDVIISDPPLHH- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 804741487 190 qdphlsegdvrfeprsalvadenGMADLTHIIDNARQMLTPGGFLLLE 237
Cdd:cd02440   79 -----------------------LVEDLARFLEEARRLLKPGGVLVLT 103
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 6-73 6.52e-16

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 70.59  E-value: 6.52e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487    6 WLHEAVNQLRDS--DSPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTG 73
Cdd:pfam17827   2 ALRWASSRLKEAgiESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
102-237 1.76e-13

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 67.33  E-value: 1.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 102 ALARLPVKTCR-ILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGqQFDMI 180
Cdd:PRK08287  23 ALSKLELHRAKhLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGNIDIIPGEAPIELPG-KADAI 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 804741487 181 vsnppYIDAQDPHLSEgdvrfeprsalvadengmadlthIIDNARQMLTPGG-----FLLLE 237
Cdd:PRK08287 102 -----FIGGSGGNLTA-----------------------IIDWSLAHLHPGGrlvltFILLE 135
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 111-244 9.40e-13

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 64.36  E-value: 9.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  111 CRILDLGTGTGAIALALACE-RPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFS---ALSGQQFDMIVSNppy 186
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEElGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEElpeLLEDDKFDVVISN--- 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 804741487  187 idaqdphlsegdvrfeprSALvadeNGMADLTHIIDNARQMLTPGGFLLLEHGWRQGE 244
Cdd:pfam13847  82 ------------------CVL----NHIPDPDKVLQEILRVLKPGGRLIISDPDSLAE 117
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 100-256 8.49e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.55  E-value: 8.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 100 EQALARLPVKTC-RILDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLAIrNVRILQSCWFS-ALSGQQF 177
Cdd:COG2226   12 EALLAALGLRPGaRVLDLGCGTGRLALALA--ERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDlPFPDGSF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 178 DMIVSNppyidaqdphlsegdvrfeprSALvadeNGMADLTHIIDNARQMLTPGG-FLLLEHGWRQGEAVRAAFRRSGYT 256
Cdd:COG2226   89 DLVISS---------------------FVL----HHLPDPERALAEIARVLKPGGrLVVVDFSPPDLAELEELLAEAGFE 143
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 99-237 8.96e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 60.80  E-value: 8.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  99 VEQALARLPVKTCRILDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLairNVRILQSCWFS-ALSGQQF 177
Cdd:COG2227   14 LAALLARLLPAGGRVLDVGCGTGRLALALA--RRGADVTGVDISPEALEIARERAAEL---NVDFVQGDLEDlPLEDGSF 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 178 DMIVSNppyidaqdphlsegDVrFEPrsalvadengMADLTHIIDNARQMLTPGGFLLLE 237
Cdd:COG2227   89 DLVICS--------------EV-LEH----------LPDPAALLRELARLLKPGGLLLLS 123
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
112-238 2.99e-11

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 58.68  E-value: 2.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 112 RILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQscwFSAlsGQQFDMIVSNppyidaqd 191
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVRFVVADLRD---LDP--PEPFDLVVSN-------- 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 804741487 192 phlsegdvrfeprSALvadeNGMADLTHIIDNARQMLTPGGFLLLEH 238
Cdd:COG4106   71 -------------AAL----HWLPDHAALLARLAAALAPGGVLAVQV 100
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 95-185 6.96e-11

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 61.73  E-value: 6.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  95 TECLVEQALARL-PVKTCRILDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALS 173
Cdd:COG2265  218 AEALYAAALEWLdLTGGERVLDLYCGVGTFALPLA--RRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLP 295

                         90
                 ....*....|....*.
gi 804741487 174 ----GQQFDMIVSNPP 185
Cdd:COG2265  296 ellwGGRPDVVVLDPP 311
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 101-237 1.36e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 59.54  E-value: 1.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 101 QALARLPvKTCRILDLGTGTGAIALALAcERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQS--CWFSALSGQQFD 178
Cdd:COG0500   19 ALLERLP-KGGRVLDLGCGTGRNLLALA-ARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAdlAELDPLPAESFD 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 804741487 179 MIVSNpPYIDAQDPhlsegdvrfeprsalvadengmADLTHIIDNARQMLTPGGFLLLE 237
Cdd:COG0500   97 LVVAF-GVLHHLPP----------------------EEREALLRELARALKPGGVLLLS 132
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 113-232 4.98e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 55.26  E-value: 4.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  113 ILDLGTGTGAIALALAcERPDCEVTAVDRMPDAVALAIRNAEHLAIrNVRILQsCWFSALS--GQQFDMIVSNPPYIdaq 190
Cdd:pfam13649   1 VLDLGCGTGRLTLALA-RRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQ-GDAEDLPfpDGSFDLVVSSGVLH--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 804741487  191 dpHLSEgdvrfeprsalvadengmADLTHIIDNARQMLTPGG 232
Cdd:pfam13649  75 --HLPD------------------PDLEAALREIARVLKPGG 96
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
97-263 9.95e-10

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 57.88  E-value: 9.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  97 CLveQALARLPVKTCRILDLGTGTG--AIALALaceRPDCEVTAVDRMPDAVALAIRNAEhlaiRN-----VRILQScwf 169
Cdd:COG2264  138 CL--EALEKLLKPGKTVLDVGCGSGilAIAAAK---LGAKRVLAVDIDPVAVEAARENAE----LNgvedrIEVVLG--- 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 170 SALSGQQFDMIVSNppyidaqdphlsegdvrfeprsaLVADEngmadLTHIIDNARQMLTPGGFL----LLEHgwrQGEA 245
Cdd:COG2264  206 DLLEDGPYDLVVAN-----------------------ILANP-----LIELAPDLAALLKPGGYLilsgILEE---QADE 254

                        170
                 ....*....|....*...
gi 804741487 246 VRAAFRRSGYTDVETCRD 263
Cdd:COG2264  255 VLAAYEAAGFELVERRER 272
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 98-236 2.89e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 54.94  E-value: 2.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  98 LVEQALARLPVK-TCRILDLGTGTGAIALALAcERPDCEVTAVDRMPDAVALAIRNAEHLAIRN-VRILQSCWFSALSGQ 175
Cdd:COG2230   39 KLDLILRKLGLKpGMRVLDIGCGWGGLALYLA-RRYGVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDLPADG 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 804741487 176 QFDMIVSnppyIDAqdphlsegdvrFEprsaLVADENgmadLTHIIDNARQMLTPGGFLLL 236
Cdd:COG2230  118 QFDAIVS----IGM-----------FE----HVGPEN----YPAYFAKVARLLKPGGRLLL 155
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 102-165 3.22e-09

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 57.10  E-value: 3.22e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 804741487 102 ALARL-PVKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQ 165
Cdd:COG2242  239 TLAKLaLRPGDVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVPNVEVVE 303
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
112-210 2.32e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 52.98  E-value: 2.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 112 RILDLGTGTGAIALALACERPDcEVTAVDRMPDAVALAIRNAEHLAiRNVRILQSCWFSALSGQQFDMIVSNPPYiDAQD 191
Cdd:COG2263   48 TVLDLGCGTGMLAIGAALLGAK-KVVGVDIDPEALEIARENAERLG-VRVDFIRADVTRIPLGGSVDTVVMNPPF-GAQR 124

                         90
                 ....*....|....*....
gi 804741487 192 PHLsegDVRFEPRSALVAD 210
Cdd:COG2263  125 RHA---DRPFLEKALEIAA 140
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 101-271 3.56e-07

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 49.03  E-value: 3.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 101 QALARLpVKTCRILDLGTGTG--AIALALACeRPDCEVTAVDRMPDAVALAIRN------AEHLAIRNVRILQscWFSAL 172
Cdd:COG4122    9 YLLARL-LGAKRILEIGTGTGysTLWLARAL-PDDGRLTTIEIDPERAAIARENfaraglADRIRLILGDALE--VLPRL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 173 SGQQFDMIvsnppYIDAqDPHlsegdvrfeprsalvadengmaDLTHIIDNARQMLTPGGFLLLEHGWRQGEAVRAAFRR 252
Cdd:COG4122   85 ADGPFDLV-----FIDA-DKS----------------------NYPDYLELALPLLRPGGLIVADNVLWHGRVADPARRD 136

                        170
                 ....*....|....*....
gi 804741487 253 sgyTDVETCRDYggNERVA 271
Cdd:COG4122  137 ---PSTRAIREF--NEYLR 150
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
112-188 5.12e-07

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 49.94  E-value: 5.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 112 RILDLGTGTGAIALALACERPDCEVTavdrMPDAVALAIRNAEH-LAIRNV--RILQSCWFSALSGQqFDMIVSNPPYID 188
Cdd:PRK09489 199 KVLDVGCGAGVLSAVLARHSPKIRLT----LSDVSAAALESSRAtLAANGLegEVFASNVFSDIKGR-FDMIISNPPFHD 273
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 114-234 1.30e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 45.82  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  114 LDLGTGTGAIALALACERPDCEVTAVDRMPDAVALA---IRNAEHLAIRNVRILQsCWFSALSGQQFDMIVSNppyidaq 190
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAArerLAALGLLNAVRVELFQ-LDLGELDPGSFDVVVAS------- 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 804741487  191 dphlsegdvrfeprSALVAdengMADLTHIIDNARQMLTPGGFL 234
Cdd:pfam08242  73 --------------NVLHH----LADPRAVLRNIRRLLKPGGVL 98
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 111-265 2.78e-06

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 46.61  E-value: 2.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 111 CRILDLGTGTGAIAL-ALA--CERpdceVTAVDRMPDAVALAIRNAEHL-AIRNVRILQS---CWFSALSGQQFDMIVSN 183
Cdd:COG0742   43 ARVLDLFAGSGALGLeALSrgAAS----VVFVEKDRKAAAVIRKNLEKLgLEDRARVIRGdalRFLKRLAGEPFDLVFLD 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 184 PPYidaqdphlsegdvrfeprsalvADENGMADLTHIIDNarQMLTPGGFLLLEHGWRQGEAVRAAfrrsGYTDVETcRD 263
Cdd:COG0742  119 PPY----------------------AKGLLEKALELLAEN--GLLAPGGLIVVEHSKREELPELPA----GLELLKE-RK 169


                 ..
gi 804741487 264 YG 265
Cdd:COG0742  170 YG 171
PRK06202 PRK06202
hypothetical protein; Provisional
 100-183 5.93e-06

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 46.15  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 100 EQALARLPVKTCRILDLGTGTGAIALALAC----ERPDCEVTAVDRMPDAVALAIRNAehlAIRNVRILQsCWFSALS-- 173
Cdd:PRK06202  51 LLRPALSADRPLTLLDIGCGGGDLAIDLARwarrDGLRLEVTAIDPDPRAVAFARANP---RRPGVTFRQ-AVSDELVae 126

                         90
                 ....*....|
gi 804741487 174 GQQFDMIVSN 183
Cdd:PRK06202 127 GERFDVVTSN 136
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
97-260 5.97e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 46.30  E-value: 5.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  97 CLveQALARLPVKTCRILDLGTGTG--AIALA-LACErpdcEVTAVDRMPDAVALAIRNAEhlaiRN-VRILqscwFSAL 172
Cdd:PRK00517 109 CL--EALEKLVLPGKTVLDVGCGSGilAIAAAkLGAK----KVLAVDIDPQAVEAARENAE----LNgVELN----VYLP 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 173 SGQ-QFDMIVSNppyIDAqDPHLsegdvrfeprsalvadengmadltHIIDNARQMLTPGGFLLL----EhgwRQGEAVR 247
Cdd:PRK00517 175 QGDlKADVIVAN---ILA-NPLL------------------------ELAPDLARLLKPGGRLILsgilE---EQADEVL 223

                        170
                 ....*....|...
gi 804741487 248 AAFRRSGYTDVET 260
Cdd:PRK00517 224 EAYEEAGFTLDEV 236
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
98-254 1.51e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 44.60  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  98 LVEQALARLP-VKTCRILDLGTGTGAIALALAcERPDcEVTAVDRMPDAVALAIRNA--EHLAIRNVRILQScwfsalSG 174
Cdd:COG4976   34 LAEELLARLPpGPFGRVLDLGCGTGLLGEALR-PRGY-RLTGVDLSEEMLAKAREKGvyDRLLVADLADLAE------PD 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 175 QQFDMIVSNppyidaqdphlsegDVrfeprsaLVAdengMADLTHIIDNARQMLTPGGFLLLE--------HGWRQGEAV 246
Cdd:COG4976  106 GRFDLIVAA--------------DV-------LTY----LGDLAAVFAGVARALKPGGLFIFSvedadgsgRYAHSLDYV 160


                 ....*...
gi 804741487 247 RAAFRRSG 254
Cdd:COG4976  161 RDLLAAAG 168
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
105-165 2.51e-05

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 44.22  E-value: 2.51e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 804741487 105 RLPVKTCrILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQ 165
Cdd:PRK07402  37 RLEPDSV-LWDIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKNVEVIE 96
PRK15001 PRK15001
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
113-186 4.45e-05

23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;


Pssm-ID: 184963 [Multi-domain]  Cd Length: 378  Bit Score: 44.25  E-value: 4.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 113 ILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEhlaiRNV-RILQSCWF---SALSGQQ---FDMIVSNPP 185
Cdd:PRK15001 232 IVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVE----TNMpEALDRCEFminNALSGVEpfrFNAVLCNPP 307


                 .
gi 804741487 186 Y 186
Cdd:PRK15001 308 F 308
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
111-238 5.25e-05

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 43.00  E-value: 5.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  111 CRILDLGTGTGAIALALACeRPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCW--FSALSGQ--QFDMIVSNPPY 186
Cdd:pfam03602  43 ARVLDLFAGSGALGLEALS-RGAKRVTLVEKDKRAVQILKENLQLLGLPGAVLVMDALlaLLRLAGKgpVFDIVFLDPPY 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 804741487  187 idaqdphlseGDVRFEPRSALVADengmadlthiidnaRQMLTPGGFLLLEH 238
Cdd:pfam03602 122 ----------AKGLIEEVLDLLAE--------------KGWLKPNALIYVET 149
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 101-165 1.16e-04

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 42.00  E-value: 1.16e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 804741487 101 QALArlPVKTCRILDLGTGTG---AIALALACErpdceVTAVDRMPDAVALAIRNAEHLAIRNVRILQ 165
Cdd:COG2518   60 EALD--LKPGDRVLEIGTGSGyqaAVLARLAGR-----VYSVERDPELAERARERLAALGYDNVTVRV 120
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 112-254 1.24e-04

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 42.86  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 112 RILDLGTGTGAIALALA---CErpdcEVTAVDRMPDAVALAIRNAE--HLAIRnVRILQS-CwFSAL-----SGQQFDMI 180
Cdd:COG1092  219 RVLNLFSYTGGFSVHAAaggAK----SVTSVDLSATALEWAKENAAlnGLDDR-HEFVQAdA-FDWLrelarEGERFDLI 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 181 VSNPPyidaqdphlsegdvRFEPRSAlvADENGMADLTHIIDNARQMLTPGGFLLL--------EHGWRqgEAVRAAFRR 252
Cdd:COG1092  293 ILDPP--------------AFAKSKK--DLFDAQRDYKDLNRLALKLLAPGGILVTsscsrhfsLDLFL--EILARAARD 354


                 ..
gi 804741487 253 SG 254
Cdd:COG1092  355 AG 356
RsmG COG0357
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ...
 101-182 2.19e-04

16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440126  Cd Length: 211  Bit Score: 41.29  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 101 QALARLPVKTCRILDLGTGTG--AIALALAceRPDCEVTAVDRMP---DAVALAIRnaeHLAIRNVRILQSCWFSALSGQ 175
Cdd:COG0357   59 ALLPLLPKEGARVLDVGSGAGfpGIPLAIA--RPDLQVTLVDSLGkkiAFLREVVR---ELGLKNVTVVHGRAEELAPRE 133


                 ....*..
gi 804741487 176 QFDMIVS 182
Cdd:COG0357  134 KFDVVTA 140
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 102-181 2.82e-04

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 41.48  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 102 ALARLPVKTCRILDLGTGTGAIALALACERPDC-EVTAVDRMPDAVALA---IRNAEHLAIRNVRILQSCWFSALSGQQF 177
Cdd:COG5459   73 AEAGPDFAPLTVLDVGAGPGTAAWAAADAWPSLlDATLLERSAAALALGrrlARAAANPALETAEWRLADLAAALPAPPA 152


                 ....
gi 804741487 178 DMIV 181
Cdd:COG5459  153 DLVV 156
Methyltransf_4 pfam02390
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ...
 113-193 5.32e-04

Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.


Pssm-ID: 367068  Cd Length: 173  Bit Score: 39.97  E-value: 5.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  113 ILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQS----CWFSALSGQQFDMIVSNPPyid 188
Cdd:pfam02390   5 FLEIGCGMGGFLVAMAKANPDKNFIGIEIRVPGVAKALKKIDALGLQNLRILCGnaldVLPNYFPPGSLQKIFINFP--- 81


                  ....*
gi 804741487  189 aqDPH 193
Cdd:pfam02390  82 --DPW 84
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
168-256 5.39e-04

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 40.29  E-value: 5.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 168 WFSALSGQQFDMIVSNPPYIDAQDPHLSEGDVRFEPrsalvADENGMADLTHIIDNARQMLTPGGFLLLEHGWRQGEAVR 247
Cdd:COG0863   10 VLKELPDESVDLIVTDPPYNLGKKYGLGRREIGNEL-----SFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYISRLI 84


                 ....*....
gi 804741487 248 AAFRRSGYT 256
Cdd:COG0863   85 AALRDAGFK 93
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
115-185 7.02e-04

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 40.24  E-value: 7.02e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 804741487 115 DLGTGTGAiaLALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRilqscwFSALSGQQF--------DMIVSNPP 185
Cdd:PRK03522 179 DLFCGVGG--FGLHCATPGMQLTGIEISAEAIACAKQSAAELGLTNVQ------FQALDSTQFataqgevpDLVLVNPP 249
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 97-252 1.18e-03

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 39.56  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487   97 CLveQALARLPVKTCRILDLGTGTGAIALA---LACErpdcEVTAVDRMPDAVALAIRNAEHLAIRNvrILQSCWFSALS 173
Cdd:pfam06325 151 CL--EALERLVKPGESVLDVGCGSGILAIAalkLGAK----KVVGVDIDPVAVRAAKENAELNGVEA--RLEVYLPGDLP 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  174 GQQFDMIVSNppyIdaqdphLSEGDVRFEPR-SALVADEnGMADLTHIIDNARQM----LTPgGFLLLEHgWRQGEAVRA 248
Cdd:pfam06325 223 KEKADVVVAN---I------LADPLIELAPDiYALVKPG-GYLILSGILKEQAQMvaeaYSQ-GFELITV-EHREEWVCI 290


                  ....
gi 804741487  249 AFRR 252
Cdd:pfam06325 291 VGKK 294
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
90-161 2.15e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 38.26  E-value: 2.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 804741487  90 IPRPDTECLVEQALArlPVKTCRILDLGTGTG---AIaLALACERpdceVTAVDRMPDAVALAIRNAEHLAIRNV 161
Cdd:PRK00312  61 ISQPYMVARMTELLE--LKPGDRVLEIGTGSGyqaAV-LAHLVRR----VFSVERIKTLQWEAKRRLKQLGLHNV 128
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 111-181 5.07e-03

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 36.93  E-value: 5.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 804741487  111 CRILDLGTGTGAIALALACERPDCEVTAVDRmPDAVALAIRNAEHLAIRN---VRIL---QSCWFSALSGQQFDMIV 181
Cdd:pfam10294  48 LNVLELGSGTGLVGIAVALLLPGASVTITDL-EEALELLKKNIELNALSSkvvVKVLdwgENLPPDLFDGHPVDLIL 123
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 114-162 6.20e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 35.33  E-value: 6.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 804741487  114 LDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLAIRNVR 162
Cdd:pfam08241   1 LDVGCGTGLLTELLA--RLGARVTGVDISPEMLELAREKAPREGLTFVV 47
PRK08317 PRK08317
hypothetical protein; Provisional
 92-154 6.26e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 37.22  E-value: 6.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 804741487  92 RPDTECLVEQALARLPVKTC-RILDLGTGTGAIALALACE-RPDCEVTAVDRMPDAVALAIRNAE 154
Cdd:PRK08317   1 LPDFRRYRARTFELLAVQPGdRVLDVGCGPGNDARELARRvGPEGRVVGIDRSEAMLALAKERAA 65
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
91-232 6.56e-03

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 37.09  E-value: 6.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487  91 PRPDTECLVEQALarlPVKTCRILDLGTGTGAIALALA--------CERPDCEVTAVDRMPDAVALAIRNaehLAIRNV- 161
Cdd:COG0286   28 PREVVRLMVELLD---PKPGETVYDPACGSGGFLVEAAeylkehggDERKKLSLYGQEINPTTYRLAKMN---LLLHGIg 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 804741487 162 --RILQSCWFSALSGQ--QFDMIVSNPPYIDAQDPHLSEGDvrFEPRSALVADENGMAD---LTHIIdnarQMLTPGG 232
Cdd:COG0286  102 dpNIELGDTLSNDGDEleKFDVVLANPPFGGKWKKEELKDD--LLGRFGYGLPPKSNADllfLQHIL----SLLKPGG 173
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 107-186 7.98e-03

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 37.03  E-value: 7.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 804741487 107 PVKTCRILDLGTGTGAIALALAcERPDcEVTAVDRMPDAVALAirnAEHLAIR-NVRILQS----CWFSALSGQQFDMIV 181
Cdd:COG0030   35 ITPGDTVLEIGPGLGALTRALL-ERAA-RVTAVEIDRRLAAIL---RETFAAYpNLTVIEGdalkVDLPALAAGEPLKVV 109


                 ....*
gi 804741487 182 SNPPY 186
Cdd:COG0030  110 GNLPY 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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