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Conserved domains on  [gi|888380748|emb|CMP74434|]
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transcriptional regulator [Mycobacterium tuberculosis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5642 super family cl47380
Uncharacterized conserved protein, DUF2384 family [Function unknown];
7-113 2.63e-13

Uncharacterized conserved protein, DUF2384 family [Function unknown];


The actual alignment was detected with superfamily member COG5642:

Pssm-ID: 444366 [Multi-domain]  Cd Length: 139  Bit Score: 61.53  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888380748   7 ASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQvvpQRLNKQ---RLIELAYVADALAEVL-PRDQANVWMFSPNRL 82
Cdd:COG5642   31 ASALDRLAELLGLSDDELAKILGISRRTLSRRKKEK---KRLSPEeseRLLRLARVLARAEEVFgDEEKARRWLRRPNRA 107

                         90       100       110
                 ....*....|....*....|....*....|..
gi 888380748  83 LEHRKPADLVR-DGEYQRVLALIDAMAEGVFV 113
Cdd:COG5642  108 LGGRTPLDLLDtEAGAELVEDLLGRIEYGVFA 139
 
Name Accession Description Interval E-value
COG5642 COG5642
Uncharacterized conserved protein, DUF2384 family [Function unknown];
7-113 2.63e-13

Uncharacterized conserved protein, DUF2384 family [Function unknown];


Pssm-ID: 444366 [Multi-domain]  Cd Length: 139  Bit Score: 61.53  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888380748   7 ASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQvvpQRLNKQ---RLIELAYVADALAEVL-PRDQANVWMFSPNRL 82
Cdd:COG5642   31 ASALDRLAELLGLSDDELAKILGISRRTLSRRKKEK---KRLSPEeseRLLRLARVLARAEEVFgDEEKARRWLRRPNRA 107

                         90       100       110
                 ....*....|....*....|....*....|..
gi 888380748  83 LEHRKPADLVR-DGEYQRVLALIDAMAEGVFV 113
Cdd:COG5642  108 LGGRTPLDLLDtEAGAELVEDLLGRIEYGVFA 139
Xre_MbcA_ParS_C pfam09722
Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal ...
 62-110 1.51e-04

Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp.. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect. These antitoxins also have a HTH domain at the N-terminal.


Pssm-ID: 462855  Cd Length: 51  Bit Score: 36.73  E-value: 1.51e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 888380748   62 ALAEVLP-RDQANVWMFSPNRLLEHRKPADLVRDGE-YQRVLALIDAMAEG 110
Cdd:pfam09722   1 AAEAVFGdDEAAARWLRTPNPALGGRTPLDLLDTEEgLRLVEDYLDRIRGG 51
TAS_TIGR02293 TIGR02293
putative toxin-antitoxin system antitoxin component, TIGR02293 family; Proteins in this family ...
 23-112 1.62e-04

putative toxin-antitoxin system antitoxin component, TIGR02293 family; Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. This family was proposed by Makarova, et al. (2009) to be the antitoxin component of a new class of type 2 toxin-antitoxin system, or addiction module. [Cellular processes, Other]


Pssm-ID: 131346 [Multi-domain]  Cd Length: 133  Bit Score: 38.21  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888380748   23 EVGDIVDASPRSVARWtagQVVPQRLNKQ---RLIELAYVADALAEVLPRD-QANVWMFSPNRLLEHRKPADLV-RDGEY 97
Cdd:TIGR02293  41 EIFKATGIPKATLQRR---KMAHQRLSSEesdRLARVARVWKAAVDVFGGDaEARQWLFRPVPGLGNRRPIDLLlTEAGA 117

                          90
                  ....*....|....*
gi 888380748   98 QRVLALIDAMAEGVF 112
Cdd:TIGR02293 118 EIVEDLLGRLEYGVY 132
 
Name Accession Description Interval E-value
COG5642 COG5642
Uncharacterized conserved protein, DUF2384 family [Function unknown];
7-113 2.63e-13

Uncharacterized conserved protein, DUF2384 family [Function unknown];


Pssm-ID: 444366 [Multi-domain]  Cd Length: 139  Bit Score: 61.53  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888380748   7 ASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQvvpQRLNKQ---RLIELAYVADALAEVL-PRDQANVWMFSPNRL 82
Cdd:COG5642   31 ASALDRLAELLGLSDDELAKILGISRRTLSRRKKEK---KRLSPEeseRLLRLARVLARAEEVFgDEEKARRWLRRPNRA 107

                         90       100       110
                 ....*....|....*....|....*....|..
gi 888380748  83 LEHRKPADLVR-DGEYQRVLALIDAMAEGVFV 113
Cdd:COG5642  108 LGGRTPLDLLDtEAGAELVEDLLGRIEYGVFA 139
Xre_MbcA_ParS_C pfam09722
Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal ...
 62-110 1.51e-04

Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp.. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect. These antitoxins also have a HTH domain at the N-terminal.


Pssm-ID: 462855  Cd Length: 51  Bit Score: 36.73  E-value: 1.51e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 888380748   62 ALAEVLP-RDQANVWMFSPNRLLEHRKPADLVRDGE-YQRVLALIDAMAEG 110
Cdd:pfam09722   1 AAEAVFGdDEAAARWLRTPNPALGGRTPLDLLDTEEgLRLVEDYLDRIRGG 51
TAS_TIGR02293 TIGR02293
putative toxin-antitoxin system antitoxin component, TIGR02293 family; Proteins in this family ...
 23-112 1.62e-04

putative toxin-antitoxin system antitoxin component, TIGR02293 family; Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. This family was proposed by Makarova, et al. (2009) to be the antitoxin component of a new class of type 2 toxin-antitoxin system, or addiction module. [Cellular processes, Other]


Pssm-ID: 131346 [Multi-domain]  Cd Length: 133  Bit Score: 38.21  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888380748   23 EVGDIVDASPRSVARWtagQVVPQRLNKQ---RLIELAYVADALAEVLPRD-QANVWMFSPNRLLEHRKPADLV-RDGEY 97
Cdd:TIGR02293  41 EIFKATGIPKATLQRR---KMAHQRLSSEesdRLARVARVWKAAVDVFGGDaEARQWLFRPVPGLGNRRPIDLLlTEAGA 117

                          90
                  ....*....|....*
gi 888380748   98 QRVLALIDAMAEGVF 112
Cdd:TIGR02293 118 EIVEDLLGRLEYGVY 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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