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Conserved domains on  [gi|888226520|emb|CLT66665|]
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NLP/P60 family protein [Mycobacterium tuberculosis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NlpC_inact_RipD NF033743
NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member ...
 10-168 1.73e-87

NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member Rv1566c from Mycobacterium tuberculosis, is a catalytically inactive paralog of the peptidoglycan endopeptidases RipA and RipB. A catalytically important Cys and His pair is replaced by Ala-83 and Ser-132.


:

Pssm-ID: 468164 [Multi-domain]  Cd Length: 177  Bit Score: 256.15  E-value: 1.73e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  10 FAIGLAMMlapMVAAPGLAAADPATRPVDYQQITDVVIARGLSQRGVPFSWAGGGISGPTRGTG---------------T 74
Cdd:NF033743   6 LVIGLALL---GLATPGLASADPVPRPADNQQAIDVVIARALSQRGVPFSYGGGNANGPTRGTGagpaalnlpgaapgaP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  75 GINTVGFDASGLIQYAYAGAGLKLPRSSGQMYKVGQKVLPQQARKGDLIFYGPEGTQSVALYLGKGQMLEVGD-VVQVSP 153
Cdd:NF033743  83 GPNVVGFDASGLMVYAFAGAGVKLPRSSGEQYKVGQKVLPAQALPGDLIFYGPEGTQSVALFLGNGQMLEATDpGVTVSP 162

                        170
                 ....*....|....*
gi 888226520 154 VRTNGMTPYLVRVLG 168
Cdd:NF033743 163 VRTNGMAPYLVRIIG 177
PRK12757 super family cl36177
cell division protein FtsN; Provisional
 149-223 3.88e-06

cell division protein FtsN; Provisional


The actual alignment was detected with superfamily member PRK12757:

Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 46.57  E-value: 3.88e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 888226520 149 VQVSPVRTNGMTPYLVRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQ-APVQQAPVQPPP 223
Cdd:PRK12757 100 TQLSEVPYNEQTPQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTTAPVQPQTPAPVRTQPaAPVTQAVEAPKV 175
 
Name Accession Description Interval E-value
NlpC_inact_RipD NF033743
NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member ...
 10-168 1.73e-87

NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member Rv1566c from Mycobacterium tuberculosis, is a catalytically inactive paralog of the peptidoglycan endopeptidases RipA and RipB. A catalytically important Cys and His pair is replaced by Ala-83 and Ser-132.


Pssm-ID: 468164 [Multi-domain]  Cd Length: 177  Bit Score: 256.15  E-value: 1.73e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  10 FAIGLAMMlapMVAAPGLAAADPATRPVDYQQITDVVIARGLSQRGVPFSWAGGGISGPTRGTG---------------T 74
Cdd:NF033743   6 LVIGLALL---GLATPGLASADPVPRPADNQQAIDVVIARALSQRGVPFSYGGGNANGPTRGTGagpaalnlpgaapgaP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  75 GINTVGFDASGLIQYAYAGAGLKLPRSSGQMYKVGQKVLPQQARKGDLIFYGPEGTQSVALYLGKGQMLEVGD-VVQVSP 153
Cdd:NF033743  83 GPNVVGFDASGLMVYAFAGAGVKLPRSSGEQYKVGQKVLPAQALPGDLIFYGPEGTQSVALFLGNGQMLEATDpGVTVSP 162

                        170
                 ....*....|....*
gi 888226520 154 VRTNGMTPYLVRVLG 168
Cdd:NF033743 163 VRTNGMAPYLVRIIG 177
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 55-167 2.24e-33

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 116.23  E-value: 2.24e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520   55 GVPFSWAGGGISGptrgtgtgintvgFDASGLIQYAYAGAGLKLPRSSGQMYKVGQK-VLPQQARKGDLIFYGPEG-TQS 132
Cdd:pfam00877   1 GVPYRWGGGSPSG-------------FDCSGLVRYAFAKVGIELPRSSGQQYNAGKKtIPKSEPQRGDLVFFGTGKgISH 67

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 888226520  133 VALYLGKGQMLEV--GDVVQVSPVRTNGMTPYLVRVL 167
Cdd:pfam00877  68 VGIYLGNGQMLHAstGGGVSISSLNGGYWQKRLVGVR 104
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
23-157 7.54e-22

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 89.76  E-value: 7.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  23 AAPGLAAADPATRPVDYQQITDVVIARGLSQRGVPFSWAGggiSGPTrgtgtgintvGFDASGLIQYAYAGAGLKLPRSS 102
Cdd:COG0791   80 KAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGG---TSPS----------GFDCSGLVQYVYRQAGISLPRTS 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520 103 GQMYKVGQKVLPQQARKGDLIFYG-PEGTQS-VALYLGKGQMLEV---GDVVQVSPVRTN 157
Cdd:COG0791  147 ADQAAAGTPVSRSELQPGDLVFFRtGGGGIShVGIYLGNGKFIHAsssGKGVRISSLDSP 206
PRK13914 PRK13914
invasion associated endopeptidase;
46-164 2.08e-15

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 74.45  E-value: 2.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  46 VIARGLSQRGVPFSWAGggiSGPTRgtgtgintvgFDASGLIQYAYAGAGLKLPRSSGQMYKVGQKVLPQQARKGDLIF- 124
Cdd:PRK13914 369 IIAEAQKHLGKAYSWGG---NGPTT----------FDCSGYTKYVFAKAGISLPRTSGAQYASTTRISESQAKPGDLVFf 435

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 888226520 125 -YGpEGTQSVALYLGKGQMLEVGDV-VQVSPVRTNGMTPYLV 164
Cdd:PRK13914 436 dYG-SGISHVGIYVGNGQMINAQDNgVKYDNIHGSGWGKYLV 476
PRK12757 PRK12757
cell division protein FtsN; Provisional
 149-223 3.88e-06

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 46.57  E-value: 3.88e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 888226520 149 VQVSPVRTNGMTPYLVRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQ-APVQQAPVQPPP 223
Cdd:PRK12757 100 TQLSEVPYNEQTPQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTTAPVQPQTPAPVRTQPaAPVTQAVEAPKV 175
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 170-230 9.07e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.02  E-value: 9.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 888226520  170 QPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPPPFGTARSR 230
Cdd:pfam09770 224 APPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQ 284
ZipA COG3115
Cell division protein ZipA, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 170-223 4.30e-03

Cell division protein ZipA, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442349 [Multi-domain]  Cd Length: 298  Bit Score: 37.36  E-value: 4.30e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 888226520 170 QPTPVQQ--APVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPPP 223
Cdd:COG3115  100 EPVRWAGtaAAVEPAPEQEAYEEAGPAGESAEQEDAPAEEPEAEAPAEEALAAELC 155
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 146-221 4.61e-03

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 37.22  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520 146 GDVVQVSPVRTNG-MTPylvrvLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQ------APVQQAPV----QQAPVQQAPV 214
Cdd:cd21974  115 ADPVPVSPPPVLCqMLP-----VSSSSGVIVAFLKAPQQPSPQPQKPALPQPqvvlvgGQVPQGPVmlvvPQPAVPQPYV 189


                 ....*..
gi 888226520 215 QQAPVQP 221
Cdd:cd21974  190 QPTVVTP 196
 
Name Accession Description Interval E-value
NlpC_inact_RipD NF033743
NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member ...
 10-168 1.73e-87

NlpC/P60 family peptidoglycan-binding protein RipD; RipD proteins, such as founding member Rv1566c from Mycobacterium tuberculosis, is a catalytically inactive paralog of the peptidoglycan endopeptidases RipA and RipB. A catalytically important Cys and His pair is replaced by Ala-83 and Ser-132.


Pssm-ID: 468164 [Multi-domain]  Cd Length: 177  Bit Score: 256.15  E-value: 1.73e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  10 FAIGLAMMlapMVAAPGLAAADPATRPVDYQQITDVVIARGLSQRGVPFSWAGGGISGPTRGTG---------------T 74
Cdd:NF033743   6 LVIGLALL---GLATPGLASADPVPRPADNQQAIDVVIARALSQRGVPFSYGGGNANGPTRGTGagpaalnlpgaapgaP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  75 GINTVGFDASGLIQYAYAGAGLKLPRSSGQMYKVGQKVLPQQARKGDLIFYGPEGTQSVALYLGKGQMLEVGD-VVQVSP 153
Cdd:NF033743  83 GPNVVGFDASGLMVYAFAGAGVKLPRSSGEQYKVGQKVLPAQALPGDLIFYGPEGTQSVALFLGNGQMLEATDpGVTVSP 162

                        170
                 ....*....|....*
gi 888226520 154 VRTNGMTPYLVRVLG 168
Cdd:NF033743 163 VRTNGMAPYLVRIIG 177
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 55-167 2.24e-33

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 116.23  E-value: 2.24e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520   55 GVPFSWAGGGISGptrgtgtgintvgFDASGLIQYAYAGAGLKLPRSSGQMYKVGQK-VLPQQARKGDLIFYGPEG-TQS 132
Cdd:pfam00877   1 GVPYRWGGGSPSG-------------FDCSGLVRYAFAKVGIELPRSSGQQYNAGKKtIPKSEPQRGDLVFFGTGKgISH 67

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 888226520  133 VALYLGKGQMLEV--GDVVQVSPVRTNGMTPYLVRVL 167
Cdd:pfam00877  68 VGIYLGNGQMLHAstGGGVSISSLNGGYWQKRLVGVR 104
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
23-157 7.54e-22

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 89.76  E-value: 7.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  23 AAPGLAAADPATRPVDYQQITDVVIARGLSQRGVPFSWAGggiSGPTrgtgtgintvGFDASGLIQYAYAGAGLKLPRSS 102
Cdd:COG0791   80 KAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGG---TSPS----------GFDCSGLVQYVYRQAGISLPRTS 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520 103 GQMYKVGQKVLPQQARKGDLIFYG-PEGTQS-VALYLGKGQMLEV---GDVVQVSPVRTN 157
Cdd:COG0791  147 ADQAAAGTPVSRSELQPGDLVFFRtGGGGIShVGIYLGNGKFIHAsssGKGVRISSLDSP 206
PRK13914 PRK13914
invasion associated endopeptidase;
46-164 2.08e-15

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 74.45  E-value: 2.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520  46 VIARGLSQRGVPFSWAGggiSGPTRgtgtgintvgFDASGLIQYAYAGAGLKLPRSSGQMYKVGQKVLPQQARKGDLIF- 124
Cdd:PRK13914 369 IIAEAQKHLGKAYSWGG---NGPTT----------FDCSGYTKYVFAKAGISLPRTSGAQYASTTRISESQAKPGDLVFf 435

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 888226520 125 -YGpEGTQSVALYLGKGQMLEVGDV-VQVSPVRTNGMTPYLV 164
Cdd:PRK13914 436 dYG-SGISHVGIYVGNGQMINAQDNgVKYDNIHGSGWGKYLV 476
PRK12757 PRK12757
cell division protein FtsN; Provisional
 149-223 3.88e-06

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 46.57  E-value: 3.88e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 888226520 149 VQVSPVRTNGMTPYLVRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQ-APVQQAPVQPPP 223
Cdd:PRK12757 100 TQLSEVPYNEQTPQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTTAPVQPQTPAPVRTQPaAPVTQAVEAPKV 175
PHA03160 PHA03160
hypothetical protein; Provisional
 171-218 5.75e-05

hypothetical protein; Provisional


Pssm-ID: 165431  Cd Length: 499  Bit Score: 43.54  E-value: 5.75e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 888226520 171 PTPV---QQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQA---PVQQAPVQQAP 218
Cdd:PHA03160 413 LPPLacsQQLPMQPLHVQQAPMQAPHVAPPPMQPPHVQQPrvlPSTDGASNEAP 466
PHA03160 PHA03160
hypothetical protein; Provisional
 176-221 6.07e-05

hypothetical protein; Provisional


Pssm-ID: 165431  Cd Length: 499  Bit Score: 43.54  E-value: 6.07e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 888226520 176 QAPVQPAPV-QQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQP 221
Cdd:PHA03160 410 HHLLPPLACsQQLPMQPLHVQQAPMQAPHVAPPPMQPPHVQQPRVLP 456
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 159-223 8.51e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.93  E-value: 8.51e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 888226520 159 MTpyLVRVLGTQP-TPVQQAPVQPAPVQQAPVQQA---PVQQAPVQQAPVQQAPVQQAPVQQAPVQPPP 223
Cdd:PRK07994 351 MT--LLRMLAFHPaAPLPEPEVPPQSAAPAASAQAtaaPTAAVAPPQAPAVPPPPASAPQQAPAVPLPE 417
PHA03160 PHA03160
hypothetical protein; Provisional
 176-222 8.59e-05

hypothetical protein; Provisional


Pssm-ID: 165431  Cd Length: 499  Bit Score: 43.15  E-value: 8.59e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 888226520 176 QAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPP 222
Cdd:PHA03160 406 PKNDHHLLPPLACSQQLPMQPLHVQQAPMQAPHVAPPPMQPPHVQQP 452
PHA03160 PHA03160
hypothetical protein; Provisional
 181-228 1.69e-04

hypothetical protein; Provisional


Pssm-ID: 165431  Cd Length: 499  Bit Score: 42.00  E-value: 1.69e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 888226520 181 PAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPPPFGTAR 228
Cdd:PHA03160 406 PKNDHHLLPPLACSQQLPMQPLHVQQAPMQAPHVAPPPMQPPHVQQPR 453
PRK08119 PRK08119
flagellar motor switch protein; Validated
 143-230 2.44e-04

flagellar motor switch protein; Validated


Pssm-ID: 236154 [Multi-domain]  Cd Length: 382  Bit Score: 41.39  E-value: 2.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520 143 LEVGDVV-----QVSPVRT-----NGMtpyLVRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAP-------VQ 205
Cdd:PRK08119 197 LKIGELIdseimQLLPVDFakelvAIL---LGEEEEEEEEVEEEEAQASPAAEPATAQAAPAPKQEQQQAPpqrqepeKE 273

                         90       100
                 ....*....|....*....|....*
gi 888226520 206 QAPVQQAPVQQAPVQPPPFGTARSR 230
Cdd:PRK08119 274 AQPVNVQPAQFQSFDPPPLATTEPR 298
PHA03247 PHA03247
large tegument protein UL36; Provisional
 170-223 6.10e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 6.10e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 888226520  170 QPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPPP 223
Cdd:PHA03247 2894 STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
169-222 7.68e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 7.68e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 888226520 169 TQPTPVQQAPVQPAPVQ---QAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPP 222
Cdd:PRK14971 384 TQPAAAPQPSAAAAASPspsQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPP 440
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 170-230 9.07e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.02  E-value: 9.07e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 888226520  170 QPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPPPFGTARSR 230
Cdd:pfam09770 224 APPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQ 284
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
80-141 1.00e-03

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 38.98  E-value: 1.00e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 888226520  80 GFDASGLIQYAYAGA-GLKLPRSSGQMYKVGQKVLPQQARKGDLI-FYGPEGTQSVALYLGKGQ 141
Cdd:PRK10838  91 GIDCSAFVQRTFREQfGLELPRSTYEQQEMGKSVSRSKLRTGDLVlFRAGSTGRHVGIYIGNNQ 154
PHA03160 PHA03160
hypothetical protein; Provisional
 170-214 1.59e-03

hypothetical protein; Provisional


Pssm-ID: 165431  Cd Length: 499  Bit Score: 39.30  E-value: 1.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 888226520 170 QPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPV 214
Cdd:PHA03160 410 HHLLPPLACSQQLPMQPLHVQQAPMQAPHVAPPPMQPPHVQQPRV 454
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 170-223 2.15e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 38.91  E-value: 2.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 888226520  170 QPTPVQQAPVQP----APVQQAPVQQAPVQQAPVQQAPVQQ-APVQQAPVQQAPVQPPP 223
Cdd:PRK10263  770 QPVAPQPQYQQPqqpvAPQPQYQQPQQPVAPQPQYQQPQQPvAPQPQYQQPQQPVAPQP 828
rne PRK10811
ribonuclease E; Reviewed
 170-223 2.52e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 38.48  E-value: 2.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 888226520  170 QPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQ----APVQQAPV---QPPP 223
Cdd:PRK10811  972 EPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATVEHnhatAPMTRAPApeyVPEA 1032
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 151-222 4.21e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 37.87  E-value: 4.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 888226520 151 VSPVRTNGMTPYLVRVLGTQPTPVQQAPVQPAPVQQAPV-QQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPP 222
Cdd:PRK14950 379 VRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVaPPVPHTPESAPKLTRAAIPVDEKPKYTPPAPPK 451
PHA03247 PHA03247
large tegument protein UL36; Provisional
 146-223 4.26e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.00  E-value: 4.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 888226520  146 GDVVQVSPVRTNGMTPYLVRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPPP 223
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
ZipA COG3115
Cell division protein ZipA, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
 170-223 4.30e-03

Cell division protein ZipA, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442349 [Multi-domain]  Cd Length: 298  Bit Score: 37.36  E-value: 4.30e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 888226520 170 QPTPVQQ--APVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPPP 223
Cdd:COG3115  100 EPVRWAGtaAAVEPAPEQEAYEEAGPAGESAEQEDAPAEEPEAEAPAEEALAAELC 155
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 176-224 4.36e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 37.71  E-value: 4.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 888226520  176 QAPVQPAPVQQAPVQQaPVQQAPVQQAPVQQAPVQ---QAPVQQAPVQPPPF 224
Cdd:pfam09770 206 QAKKPAQQPAPAPAQP-PAAPPAQQAQQQQQFPPQiqqQQQPQQQPQQPQQH 256
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 146-221 4.61e-03

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 37.22  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520 146 GDVVQVSPVRTNG-MTPylvrvLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQ------APVQQAPV----QQAPVQQAPV 214
Cdd:cd21974  115 ADPVPVSPPPVLCqMLP-----VSSSSGVIVAFLKAPQQPSPQPQKPALPQPqvvlvgGQVPQGPVmlvvPQPAVPQPYV 189


                 ....*..
gi 888226520 215 QQAPVQP 221
Cdd:cd21974  190 QPTVVTP 196
PRK12757 PRK12757
cell division protein FtsN; Provisional
 169-227 4.91e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 37.33  E-value: 4.91e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520 169 TQPTPVQQAPVQPAPVQQAPvQQAPVQQAPVQQAPVQQAPVQ-QAPVQQAPVQPPPFGTA 227
Cdd:PRK12757 111 TPQVPRSTVQIQQQAQQQQP-PATTAQPQPVTPPRQTTAPVQpQTPAPVRTQPAAPVTQA 169
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 168-227 5.26e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 37.41  E-value: 5.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520 168 GTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPvqQAPVQPPPFGTA 227
Cdd:PRK14965 381 APAPPSAAWGAPTPAAPAAPPPAAAPPVPPAAPARPAAARPAPAPA--PPAAAAPPARSA 438
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 144-230 5.35e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 37.54  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 888226520 144 EVGDVVQVSPVRTNGMTPYLVRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQ-QAPVQQAPVQQAPVQQAPVQQAPVQPP 222
Cdd:PRK07994 363 APLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPlPETTSQLLAARQQLQRAQGATKAKKSE 442


                 ....*...
gi 888226520 223 PFGTARSR 230
Cdd:PRK07994 443 PAAASRAR 450
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 153-223 5.73e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 37.76  E-value: 5.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 888226520  153 PVRTNGMTPYLVRVLGTQPTPVQQAPVQPAPVQQAPVQQ----APVQQAPVQQAPVQQAPVQQAPvqQAPVQPPP 223
Cdd:PRK10263  743 PLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPqqpvAPQPQYQQPQQPVAPQPQYQQP--QQPVAPQP 815
valS PRK14900
valyl-tRNA synthetase; Provisional
 150-220 5.86e-03

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 37.66  E-value: 5.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 888226520  150 QVSPVRTNGMTPYLVRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQ 220
Cdd:PRK14900  958 QAATAVASGIEKVAEAVRKTVRRSVKKAAATRAAMKKKVAKKAPAKKAAAKKAAAKKAAAKKKVAKKAPAK 1028
PHA03378 PHA03378
EBNA-3B; Provisional
 150-227 6.09e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 37.35  E-value: 6.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 888226520 150 QVSPVRTNGMTPYLVRVLGTQPTPVQQAPVQPAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQQAPVQPPPFGTA 227
Cdd:PHA03378 708 AAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPA 785
PHA01929 PHA01929
putative scaffolding protein
 170-227 7.22e-03

putative scaffolding protein


Pssm-ID: 177328  Cd Length: 306  Bit Score: 36.96  E-value: 7.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 888226520 170 QPTPVQQAPVQPAPVQQAPVQQA--PVQQ-APVQQAPVQQAPVQQAPVQQAPVQPPPFGTA 227
Cdd:PHA01929  28 QPNPVIQPQAPVQPGQPGAPQQLaiPTQQpQPVPTSAMTPHVVQQAPAQPAPAAPPAAGAA 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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