NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|887957238|emb|CLR06869|]
View 

low molecular weight T-cell antigen [Mycobacterium tuberculosis]

Protein Classification

hemophore-related protein( domain architecture ID 10025313)

hemophore-related protein belonging to the Rv0203/Rv1174c family, similar to Mycobacterium tuberculosis low molecular weight T-cell antigen

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
MTB_hemophore TIGR04529
hemophore-related protein, Rv0203/Rv1174c family; Members of this family occur as paralogs in ...
39-110 9.46e-16

hemophore-related protein, Rv0203/Rv1174c family; Members of this family occur as paralogs in most Mycobacterium strains, including 2 in M. tuberculosis, 6 in M. avium, and 9 in M. smegmatis. Members have a cleaved N-terminal signal peptide and exactly two Cys residues in the mature protein, both at invariant positions. The best characterized member, Rv0203, is a hemophore, that is, a secreted polypeptide that binds heme and delivers it to a transport system for import. Hemophores are protein analogs of siderophores, natural products that chelate non-heme iron and deliver it to receptors for transport. The unrelated HasA family of hemophores has been described in Gram-negative bacteria such as Yersinia pestis and Pseudomonas aeruginosa. [Transport and binding proteins, Other]


:

Pssm-ID: 275322  Cd Length: 77  Bit Score: 66.16  E-value: 9.46e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 887957238   39 CNYGQVVAALNATDPGAAAQFNASPVAQSYLRNFLAAPPPQR-AAMAAQLQAVPGAAQYI----GLVESVAGSCNNY 110
Cdd:TIGR04529   1 CTAAQVAAALSAVAPAAAAYLDAHPDANQFLTAFLAQPPDQRqAAVQAYFDANPQVAAELrairQPLTDLANTCGNY 77
 
Name Accession Description Interval E-value
MTB_hemophore TIGR04529
hemophore-related protein, Rv0203/Rv1174c family; Members of this family occur as paralogs in ...
39-110 9.46e-16

hemophore-related protein, Rv0203/Rv1174c family; Members of this family occur as paralogs in most Mycobacterium strains, including 2 in M. tuberculosis, 6 in M. avium, and 9 in M. smegmatis. Members have a cleaved N-terminal signal peptide and exactly two Cys residues in the mature protein, both at invariant positions. The best characterized member, Rv0203, is a hemophore, that is, a secreted polypeptide that binds heme and delivers it to a transport system for import. Hemophores are protein analogs of siderophores, natural products that chelate non-heme iron and deliver it to receptors for transport. The unrelated HasA family of hemophores has been described in Gram-negative bacteria such as Yersinia pestis and Pseudomonas aeruginosa. [Transport and binding proteins, Other]


Pssm-ID: 275322  Cd Length: 77  Bit Score: 66.16  E-value: 9.46e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 887957238   39 CNYGQVVAALNATDPGAAAQFNASPVAQSYLRNFLAAPPPQR-AAMAAQLQAVPGAAQYI----GLVESVAGSCNNY 110
Cdd:TIGR04529   1 CTAAQVAAALSAVAPAAAAYLDAHPDANQFLTAFLAQPPDQRqAAVQAYFDANPQVAAELrairQPLTDLANTCGNY 77
 
Name Accession Description Interval E-value
MTB_hemophore TIGR04529
hemophore-related protein, Rv0203/Rv1174c family; Members of this family occur as paralogs in ...
39-110 9.46e-16

hemophore-related protein, Rv0203/Rv1174c family; Members of this family occur as paralogs in most Mycobacterium strains, including 2 in M. tuberculosis, 6 in M. avium, and 9 in M. smegmatis. Members have a cleaved N-terminal signal peptide and exactly two Cys residues in the mature protein, both at invariant positions. The best characterized member, Rv0203, is a hemophore, that is, a secreted polypeptide that binds heme and delivers it to a transport system for import. Hemophores are protein analogs of siderophores, natural products that chelate non-heme iron and deliver it to receptors for transport. The unrelated HasA family of hemophores has been described in Gram-negative bacteria such as Yersinia pestis and Pseudomonas aeruginosa. [Transport and binding proteins, Other]


Pssm-ID: 275322  Cd Length: 77  Bit Score: 66.16  E-value: 9.46e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 887957238   39 CNYGQVVAALNATDPGAAAQFNASPVAQSYLRNFLAAPPPQR-AAMAAQLQAVPGAAQYI----GLVESVAGSCNNY 110
Cdd:TIGR04529   1 CTAAQVAAALSAVAPAAAAYLDAHPDANQFLTAFLAQPPDQRqAAVQAYFDANPQVAAELrairQPLTDLANTCGNY 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH