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Conserved domains on  [gi|875607988|emb|CGO53724|]
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transmembrane efflux protein [Salmonella enterica subsp. enterica serovar Typhi]

Protein Classification

MFS transporter( domain architecture ID 1001490)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  9529885|26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10504 super family cl32521
putative transporter; Provisional
 1-281 3.51e-58

putative transporter; Provisional


The actual alignment was detected with superfamily member PRK10504:

Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 193.02  E-value: 3.51e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988   1 MPNFTTPRRKFDMTGFFLFGLSLVLFSsgMELFGEK---IVATWIAsAIIFCSIVLLLAYIRHARRHPTPLISLSLFKTR 77
Cdd:PRK10504 185 MPNYTMQTRRFDLSGFLLLAVGMATLT--LALDGSKglgLSPLAIA-GLVAVGVVALLLYLLHARNNNRALFSLKLFRTR 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  78 TFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITvfIGLMI 157
Cdd:PRK10504 262 TFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATT--LGLAL 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 158 AQFSFQSPAMPIWMLVLP--LFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIY--- 232
Cdd:PRK10504 340 VSLLFMLVALLGWYYLLPfvLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFgqq 419

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 875607988 233 ---EGFAGTSTVeqFHYTFITMGAITIVSALMFMLLRAKDGNNLIKERHKSK 281
Cdd:PRK10504 420 hvsVDSGATHTV--FMYTYLCMALIIALPALIFARVPNDTHQNVAISRRKRS 469
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
 1-281 3.51e-58

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 193.02  E-value: 3.51e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988   1 MPNFTTPRRKFDMTGFFLFGLSLVLFSsgMELFGEK---IVATWIAsAIIFCSIVLLLAYIRHARRHPTPLISLSLFKTR 77
Cdd:PRK10504 185 MPNYTMQTRRFDLSGFLLLAVGMATLT--LALDGSKglgLSPLAIA-GLVAVGVVALLLYLLHARNNNRALFSLKLFRTR 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  78 TFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITvfIGLMI 157
Cdd:PRK10504 262 TFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATT--LGLAL 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 158 AQFSFQSPAMPIWMLVLP--LFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIY--- 232
Cdd:PRK10504 340 VSLLFMLVALLGWYYLLPfvLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFgqq 419

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 875607988 233 ---EGFAGTSTVeqFHYTFITMGAITIVSALMFMLLRAKDGNNLIKERHKSK 281
Cdd:PRK10504 420 hvsVDSGATHTV--FMYTYLCMALIIALPALIFARVPNDTHQNVAISRRKRS 469
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 66-266 2.51e-43

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 151.96  E-value: 2.51e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  66 TPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKT 145
Cdd:cd17503  167 APLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLL 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 146 LVGITVFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAIS 225
Cdd:cd17503  247 LLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALL 326

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 875607988 226 AAVLRIYEGFAGT-------------STVEQFHYTFITMGAITIVSALMFMLLR 266
Cdd:cd17503  327 ATLLTNRTQFHHSrlsellaqqvqkqALIIAFNDAFLVSAILLLVGLLLALFLR 380
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
41-220 2.95e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.07  E-value: 2.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  41 WIASAIIFCSIVLLLAYIR---HARRHPTPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGC 117
Cdd:COG2814  168 LVNAVLALLALLLLLRLLPesrPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 118 MMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFqspAMPIWMLVLPLFILGMAMSTQFTAMNTITLAD 197
Cdd:COG2814  248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                        170       180
                 ....*....|....*....|...
gi 875607988 198 LTDDNASSGNSVLAVTQQLSISL 220
Cdd:COG2814  325 APPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
41-221 1.48e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988   41 WIASAIIFCSIVLLLAYIRHARRHPTP---------LISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVgFGYP 111
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKpaeearlslIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLS 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  112 ALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMN 191
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313

                         170       180       190
                  ....*....|....*....|....*....|
gi 875607988  192 TITLADLTDDNASSGNSVLAVTQQLSISLG 221
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
PRK10504 PRK10504
putative transporter; Provisional
 1-281 3.51e-58

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 193.02  E-value: 3.51e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988   1 MPNFTTPRRKFDMTGFFLFGLSLVLFSsgMELFGEK---IVATWIAsAIIFCSIVLLLAYIRHARRHPTPLISLSLFKTR 77
Cdd:PRK10504 185 MPNYTMQTRRFDLSGFLLLAVGMATLT--LALDGSKglgLSPLAIA-GLVAVGVVALLLYLLHARNNNRALFSLKLFRTR 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  78 TFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITvfIGLMI 157
Cdd:PRK10504 262 TFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATT--LGLAL 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 158 AQFSFQSPAMPIWMLVLP--LFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIY--- 232
Cdd:PRK10504 340 VSLLFMLVALLGWYYLLPfvLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFgqq 419

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 875607988 233 ---EGFAGTSTVeqFHYTFITMGAITIVSALMFMLLRAKDGNNLIKERHKSK 281
Cdd:PRK10504 420 hvsVDSGATHTV--FMYTYLCMALIIALPALIFARVPNDTHQNVAISRRKRS 469
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 66-266 2.51e-43

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 151.96  E-value: 2.51e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  66 TPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKT 145
Cdd:cd17503  167 APLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLL 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 146 LVGITVFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAIS 225
Cdd:cd17503  247 LLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALL 326

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 875607988 226 AAVLRIYEGFAGT-------------STVEQFHYTFITMGAITIVSALMFMLLR 266
Cdd:cd17503  327 ATLLTNRTQFHHSrlsellaqqvqkqALIIAFNDAFLVSAILLLVGLLLALFLR 380
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 67-266 3.82e-20

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 89.15  E-value: 3.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  67 PLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTL 146
Cdd:cd17321  158 PIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 147 VGITVFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISA 226
Cdd:cd17321  238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 875607988 227 AVL-------------RIYEGFAGTSTVEQFHYTFITMGAITIVSALMFMLLR 266
Cdd:cd17321  318 ALLtaglsanlgdsgvAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 66-266 2.38e-14

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 72.23  E-value: 2.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  66 TPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQ----VGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLG 141
Cdd:cd17504  166 VPLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVG 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 142 YRKTLVGITVFIGLMIAQFSFQSPAmpIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLG 221
Cdd:cd17504  246 PRRVLLIGLVISAVGLLLLALLHSS--LWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIG 323

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 875607988 222 VAISAAVL---RIYEGFAGTSTVEQFHYTFITMGAITIVSALMFMLLR 266
Cdd:cd17504  324 PAIAGAILttyTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
41-220 2.95e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.07  E-value: 2.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  41 WIASAIIFCSIVLLLAYIR---HARRHPTPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGC 117
Cdd:COG2814  168 LVNAVLALLALLLLLRLLPesrPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 118 MMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFqspAMPIWMLVLPLFILGMAMSTQFTAMNTITLAD 197
Cdd:COG2814  248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                        170       180
                 ....*....|....*....|...
gi 875607988 198 LTDDNASSGNSVLAVTQQLSISL 220
Cdd:COG2814  325 APPEARGRASGLYNSAFFLGGPL 347
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 67-227 1.84e-09

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 57.57  E-value: 1.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  67 PLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTL 146
Cdd:cd17502  157 PIGGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPL 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 147 VGITVFIGLM-IAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAIS 225
Cdd:cd17502  237 IVIGTILMSVgAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT 316


                 ..
gi 875607988 226 AA 227
Cdd:cd17502  317 DV 318
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
16-265 4.14e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 53.75  E-value: 4.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  16 FFLFGLSLVLFSSGMELFGEKIVAtWIASAIIFCSIVLLLAYIRHARRHPTPLISL-----SLFKTRTFSVGIAGNLATR 90
Cdd:COG2211  163 ASVLPPPLVAAFGGDAALGYRLTA-LIFAVLGLLAFLLTFFGTKERPVPEEEKVSLkeslkALLKNRPFLLLLLAYLLFF 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  91 LGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFqSPAMPIW 170
Cdd:COG2211  242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF-LGPGNLW 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 171 MLVLPLFILGMAMSTQFTAMNTItLADLTD--------DNASSGNSVLAVTQQLSISLGVAISAAVLRIYEGFAGT---- 238
Cdd:COG2211  321 LLLVLAALAGIGLGAILVLPWAM-LADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAaqsp 399

                        250       260
                 ....*....|....*....|....*..
gi 875607988 239 STVEQFHYTFITMGAITIVSALMFMLL 265
Cdd:COG2211  400 SALTGIRLLFFLLPAVLLLLAALLLLF 426
MFS_1 pfam07690
Major Facilitator Superfamily;
41-221 1.48e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988   41 WIASAIIFCSIVLLLAYIRHARRHPTP---------LISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVgFGYP 111
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKpaeearlslIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLS 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  112 ALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMN 191
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313

                         170       180       190
                  ....*....|....*....|....*....|
gi 875607988  192 TITLADLTDDNASSGNSVLAVTQQLSISLG 221
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALG 343
PRK14995 PRK14995
SmvA family efflux MFS transporter;
23-224 1.62e-06

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 48.96  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  23 LVLFSSGMELFGEkiVATWIASAIIFCSIVLLLAYIRHARRHPTPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPL 102
Cdd:PRK14995 207 LLVYSAKTALKGF--LSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQ 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 103 MLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKT-----LVGITVFIGLMIAQFSFQSPAMPIWMLvlplf 177
Cdd:PRK14995 285 ELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVatggmALSALSFYGLAMTDFSTQQWQAWGLMA----- 359

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 875607988 178 ILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAI 224
Cdd:PRK14995 360 LLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAI 406
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 38-265 6.02e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.22  E-value: 6.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  38 VATWIASAIIFCSIVLLLAYIRHARRHPTPLISLS----------LFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVG 107
Cdd:cd06173  159 GAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLlrdlreglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 108 FGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFQSpamPIWMLVLPLFILGMAMSTQF 187
Cdd:cd06173  239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP---SLWLLLAALFLLGLAGGLFN 315

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 875607988 188 TAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLriyeGFAGTSTVeqfhytFITMGAITIVSALMFMLL 265
Cdd:cd06173  316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA----DALGLSAV------FLLAGALLLLAALLLLLL 383
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 109-228 2.90e-05

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 44.95  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 109 GYPALIAGCMMAPTALGSIIAKSTVTQVLRRLgyRKTLVGITVFIGLMIAQ--FSFQSPAMPIWMLVLPLFIL---GMAM 183
Cdd:cd17476  208 GYSPLLTSARFIPMAIGGVLAAITVGFLIARL--PPSYIMAISMVAFLVGPilFATMPVHQTYWAQAFPAMIVapfGMDF 285

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 875607988 184 StqFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAV 228
Cdd:cd17476  286 S--FPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAGTV 328
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 101-226 3.89e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 44.49  E-value: 3.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 101 PLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTL-VGITVFIGLMIAQFSFQSP-AMPIWMLVLPLFI 178
Cdd:cd17320  225 PFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLrLGLLLLLAAALVLLLAALLgGLSLWPLVAPLFL 304

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 875607988 179 LGMAMSTQFTAMNTITLADLTDDnASSGNSVLAVTQQLSISLGVAISA 226
Cdd:cd17320  305 IFFGFGLIFPNATSLALEPFPHV-AGTASALLGFLQFLIGALAGALVG 351
MFS_1 pfam07690
Major Facilitator Superfamily;
85-281 4.51e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.33  E-value: 4.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988   85 GNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFQS 164
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  165 PampIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIYEgfagtstveqF 244
Cdd:pfam07690  84 S---LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG----------W 150

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 875607988  245 HYTFITMGAITIVSALMFMLLRAKDGNNLIKERHKSK 281
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEAR 187
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
112-266 2.45e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.15  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 112 ALIAGCMMAPTALGSIIAkstvTQVLRRLGYRKTLVGITVFIGLMIAQFSFqspAMPIWMLVLPLFILGMAMSTQFTAMN 191
Cdd:COG0738   46 GLLLFAFFLGYLLASLPA----GRLIDRFGYKRGLLLGLLLMALGLLLFAL---APSYPLLLLALFLLGLGLGLLDVAAN 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 875607988 192 TItLADLTDDNASSGNSVLavtqQLSISLGVAISAAVLRIyegFAGTSTVEQFHYTFITMGAITIVSALMFMLLR 266
Cdd:COG0738  119 PY-VAALGPETAASRLNLL----HAFFSLGALLGPLLGGL---LILLGLSLSWHLPYLILAVLLLLLALLFLRSK 185
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 95-266 8.30e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 8.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  95 CVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVgitVFIGLMIAQFSFQSPAMPIWMLVL 174
Cdd:cd17473  215 VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLA---IGFALMALGFLLLALASGLWVVLL 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 175 PLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLavtqQLSISLGVAISAAVLRIYEGFAGTstveqFHYTFITMGAI 254
Cdd:cd17473  292 GAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIV----TSAFFLGQFLSPLVLGPLVNLTGG-----LSGAFLILGVL 362

                        170
                 ....*....|..
gi 875607988 255 TIVSALMFMLLR 266
Cdd:cd17473  363 ALVLAIVLLLLR 374
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 83-268 9.06e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 9.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  83 IAGNLATRLGTGCVPFLMPLMLQvGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSF 162
Cdd:cd17477    2 LLSVALLGLGSGLLLPLLSLRLE-REGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 163 qSPAMPIWMLVlpLFILGMAMSTQFTAMNTITladltddNASSGNS----VLAVtQQLSISLGVAISAAVLriyeGFAGT 238
Cdd:cd17477   81 -TDSPWVWFLL--RFVMGIGLAGLFVVSESWL-------NALATNEnrgrVLGL-YSTVLGLGFALGPLLL----ALVGT 145

                        170       180       190
                 ....*....|....*....|....*....|
gi 875607988 239 STVEqfhyTFITMGAITIVSALMFMLLRAK 268
Cdd:cd17477  146 AGAL----PFLIAAVLLLLALVPLLLTRRA 171
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 83-265 1.08e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.29  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  83 IAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSF 162
Cdd:cd17329    5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 163 qspAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIYegfagtstve 242
Cdd:cd17329   85 ---AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS---------- 151

                        170       180
                 ....*....|....*....|...
gi 875607988 243 qFHYTFITMGAITIVSALMFMLL 265
Cdd:cd17329  152 -FRLLFLAAAVLFLLAALVLLFL 173
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
98-268 1.43e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.85  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  98 FLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAqFSFQSPAMPIWMLVLPLF 177
Cdd:COG2271  201 TWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA-LLLLALLPSPALAIALLF 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 178 ILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIYegfagtstveQFHYTFITMGAITIV 257
Cdd:COG2271  280 LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT----------GYQAAFLLLAALALL 349

                        170
                 ....*....|.
gi 875607988 258 SALMFMLLRAK 268
Cdd:COG2271  350 AALLALLLLRE 360
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 18-201 2.36e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  18 LFGLSLVLFSSGMELFGEKIVATWIASAIIFCSIVLLLAYIRHARRHPTPLISLSLFKTRTFS-VGIAGNLATRLGTGCV 96
Cdd:cd17477  128 VLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIApLALLGAFVAGFLEGAF 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  97 PFLMPLMLqVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVfIGLMIAQFSFQSPAMPIWMLVLpL 176
Cdd:cd17477  208 YSLLPLYG-LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCAL-LGALAALLLPLVPGLPLALLVL-L 284

                        170       180
                 ....*....|....*....|....*
gi 875607988 177 FILGMAMstqfTAMNTITLADLTDD 201
Cdd:cd17477  285 FLWGGAA----GPLYTLALALAGDR 305
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 42-229 4.04e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 38.30  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  42 IASAIIFCSIVLLLAYIRHARRHPTPLIS--LSLFKTRTFSVGIAGNLATRLGTGCV-PFLMPLMLQVGFGYPALIAGCM 118
Cdd:cd17324  161 VLALLAALLLWRLLPSLPPKKPGSLGLLSslLLLLRNPRLRLAYLITFLLFGGFFALyTYLAPFLTDVPGFSSSAIIGLL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 119 MApTALGSIIAKSTVTQVLRRLGYRKTLVGitvFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTItLADL 198
Cdd:cd17324  241 LL-FGVAGVVGSPLAGRLADRGGRRALLIA---LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRL 315

                        170       180       190
                 ....*....|....*....|....*....|.
gi 875607988 199 TDDNASSGNSVLAVTQQLSISLGVAISAAVL 229
Cdd:cd17324  316 APEARGLASSLYLAAYNLGGALGAALGGLVL 346
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
32-212 6.04e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 37.91  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  32 LFGEKIVATWIASAIIFCSIVLLLAYI-----------RHARRHPTPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLM 100
Cdd:COG0738  154 LILLGLSLSWHLPYLILAVLLLLLALLflrsklpeieeEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 101 PLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFQSPAmpiWMLVLPLFILG 180
Cdd:COG0738  234 PLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGP---WLALIGLALVG 310

                        170       180       190
                 ....*....|....*....|....*....|..
gi 875607988 181 MAMSTQFTAMNTITLADLTDDNASSGNSVLAV 212
Cdd:COG0738  311 LGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 83-277 6.88e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 37.59  E-value: 6.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988  83 IAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMA---PTALGSIIAkstvTQVLRRLGYRKTLVG--ITVFIGLMI 157
Cdd:cd06173    5 WLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAfflPFLLFSPFA----GVLADRFDRRRLLILadLLRALLAAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 875607988 158 AQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLriyegfag 237
Cdd:cd06173   81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV-------- 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 875607988 238 tsTVEQFHYTFITMGAITIVSALMFMLLRAKDGNNLIKER 277
Cdd:cd06173  153 --ALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESS 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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