|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09328 |
PRK09328 |
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional |
1-275 |
9.71e-136 |
|
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
Pssm-ID: 236467 [Multi-domain] Cd Length: 275 Bit Score: 384.13 E-value: 9.71e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 1 MDFQHWLHEAVNQLRDsdsPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSL 80
Cdd:PRK09328 2 MTIAEALREATARLAS---PRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 81 PLFVSPATLIPRPDTECLVEQALARLP-VKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIR 159
Cdd:PRK09328 79 DFKVSPGVLIPRPETEELVEWALEALLlKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLGA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 160 NVRILQSCWFSALSGQQFDMIVSNPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNACQMLTPGGFLLLEH 238
Cdd:PRK09328 159 RVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWLLLEI 238
|
250 260 270
....*....|....*....|....*....|....*..
gi 812479181 239 GWRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGRF 275
Cdd:PRK09328 239 GYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
|
|
| HemK |
COG2890 |
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ... |
1-274 |
3.22e-128 |
|
Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442135 [Multi-domain] Cd Length: 282 Bit Score: 365.24 E-value: 3.22e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 1 MDFQHWLHEAVNQLRD--SDSPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFW 78
Cdd:COG2890 1 MTIRELLRWAAARLAAagVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 79 SLPLFVSPATLIPRPDTECLVEQALARLP-VKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLA 157
Cdd:COG2890 81 GLEFKVDPGVLIPRPETEELVELALALLPaGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 158 IRN-VRILQSCWFSALSG-QQFDMIVSNPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNACQMLTPGGFL 234
Cdd:COG2890 161 LEDrVRFLQGDLFEPLPGdGRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGWL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 812479181 235 LLEHGWRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGR 274
Cdd:COG2890 241 LLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVAR 280
|
|
| RF_mod_PrmC |
TIGR03534 |
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ... |
23-272 |
8.24e-128 |
|
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]
Pssm-ID: 274634 [Multi-domain] Cd Length: 250 Bit Score: 362.94 E-value: 8.24e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 23 DAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSLPLFVSPATLIPRPDTECLVEQA 102
Cdd:TIGR03534 1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 103 LARLPVKTcRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGQQFDMIVS 182
Cdd:TIGR03534 81 LERLKKGP-RVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSGKFDLIVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 183 NPPYIDAQDPHLSEGDVR-FEPRSALVADENGMADLTHIIDNACQMLTPGGFLLLEHGWRQGEAVRAAFRRSGYTDVETC 261
Cdd:TIGR03534 160 NPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETR 239
|
250
....*....|.
gi 812479181 262 RDYGGNERVAC 272
Cdd:TIGR03534 240 KDLAGKDRVVL 250
|
|
| hemK_fam |
TIGR00536 |
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ... |
1-274 |
2.12e-117 |
|
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]
Pssm-ID: 273125 [Multi-domain] Cd Length: 284 Bit Score: 338.17 E-value: 2.12e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 1 MDFQHWLHEAVNQLRDSDSPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSL 80
Cdd:TIGR00536 4 QEFLRWASSALSRAIARENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKGVPVAYLLGSKEFYGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 81 PLFVSPATLIPRPDTECLVEQALARLPVK--TCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAI 158
Cdd:TIGR00536 84 EFFVNEHVLIPRPETEELVEKALASLISQppILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 159 -RNVRILQSCWFSALSGQQFDMIVSNPPYIDAQDPHLSEGDVRFEPRSALVADENGMADLTHIIDNACQMLTPGGFLLLE 237
Cdd:TIGR00536 164 eHRVEFIQSNLFEPLAGQKIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYLKPNGFLVCE 243
|
250 260 270
....*....|....*....|....*....|....*...
gi 812479181 238 HG-WRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGR 274
Cdd:TIGR00536 244 IGnWQQKSLKELLRIKFTWYDVENGRDLNGKERVVLGF 281
|
|
| PRK14966 |
PRK14966 |
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ... |
1-275 |
1.09e-62 |
|
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional
Pssm-ID: 184930 [Multi-domain] Cd Length: 423 Bit Score: 203.00 E-value: 1.09e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 1 MDFQHWLheAVNQLrdsdsPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSL 80
Cdd:PRK14966 151 MTFDEWL--GLSKL-----PKNEARMLLQYASEYTRVQLLTRGGEEMPDEVRQRADRLAQRRLNGEPVAYILGVREFYGR 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 81 PLFVSPATLIPRPDTECLVEQALARLPvKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRn 160
Cdd:PRK14966 224 RFAVNPNVLIPRPETEHLVEAVLARLP-ENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAADLGAR- 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 161 VRILQSCWFSA--LSGQQFDMIVSNPPYIDAQDPHLSEGDVRFEPRSALVADENGMADLTHIIDNACQMLTPGGFLLLEH 238
Cdd:PRK14966 302 VEFAHGSWFDTdmPSEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEH 381
|
250 260 270
....*....|....*....|....*....|....*..
gi 812479181 239 GWRQGEAVRAAFRRSGYTDVETCRDYGGNERVACGRF 275
Cdd:PRK14966 382 GFDQGAAVRGVLAENGFSGVETLPDLAGLDRVTLGKY 418
|
|
| PRK01544 |
PRK01544 |
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ... |
18-270 |
5.05e-49 |
|
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed
Pssm-ID: 234958 [Multi-domain] Cd Length: 506 Bit Score: 169.28 E-value: 5.05e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 18 DSPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTGLREFWSLPLFVSPATLIPRPDTEC 97
Cdd:PRK01544 22 SSPQLEARILLQHVINKPIEYLLINLDEQLNEAEIEAFEKLLERRLKHEPIAYITGVKEFYSREFIVNKHVLIPRSDTEV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 98 LVEQAL-------------------------ARLPVKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRN 152
Cdd:PRK01544 102 LVDVVFqchsresgnpekkqlnpcfrgndisSNCNDKFLNILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSN 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 153 A-EHLAIRNVRILQSCWFSALSGQQFDMIVSNPPYID-AQDPHLSEGDVRFEPRSALVADENGMADLTHIIDNACQMLTP 230
Cdd:PRK01544 182 AiKYEVTDRIQIIHSNWFENIEKQKFDFIVSNPPYIShSEKSEMAIETINYEPSIALFAEEDGLQAYFIIAENAKQFLKP 261
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 812479181 231 GGFLLLEHGWRQGEAVRAAFRRSGYTDVETCRDYGGNERV 270
Cdd:PRK01544 262 NGKIILEIGFKQEEAVTQIFLDHGYNIESVYKDLQGHSRV 301
|
|
| L3_gln_methyl |
TIGR03533 |
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ... |
67-239 |
2.22e-37 |
|
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]
Pssm-ID: 274633 [Multi-domain] Cd Length: 284 Bit Score: 133.41 E-value: 2.22e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 67 PIAYLTGLREFWSLPLFVSPATLIPRPDTECLVEQALARL----PVKtcRILDLGTGTGAIALALACERPDCEVTAVDRM 142
Cdd:TIGR03533 77 PVAYLTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWlepePVK--RILDLCTGSGCIAIACAYAFPEAEVDAVDIS 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 143 PDAVALAIRN-AEHLAIRNVRILQSCWFSALSGQQFDMIVSNPPYIDAQD----PHlsegDVRFEPRSALVADENGMaDL 217
Cdd:TIGR03533 155 PDALAVAEINiERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDmadlPA----EYHHEPELALASGEDGL-DL 229
|
170 180
....*....|....*....|...
gi 812479181 218 TH-IIDNACQMLTPGGFLLLEHG 239
Cdd:TIGR03533 230 VRrILAEAADHLNENGVLVVEVG 252
|
|
| TrmN6 |
COG4123 |
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ... |
112-254 |
2.34e-24 |
|
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443299 [Multi-domain] Cd Length: 238 Bit Score: 97.91 E-value: 2.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 112 RILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRN-VRILQSC---WFSALSGQQFDMIVSNPPYI 187
Cdd:COG4123 40 RVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDlkeFAAELPPGSFDLVVSNPPYF 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 812479181 188 DAQDPHLSEGDVRfepRSALVADENGMADLthiIDNACQMLTPGGFLLLEHGWRQGEAVRAAFRRSG 254
Cdd:COG4123 120 KAGSGRKSPDEAR---AIARHEDALTLEDL---IRAAARLLKPGGRFALIHPAERLAEILAALRKYG 180
|
|
| PrmC_rel_meth |
TIGR03704 |
putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein ... |
61-263 |
1.58e-23 |
|
putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification]
Pssm-ID: 274733 [Multi-domain] Cd Length: 251 Bit Score: 96.01 E-value: 1.58e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 61 RRKQGEPIAYLTGLREFWSLPLFVSPATLIPRPDTECLVEQALARLPVKTCR--ILDLGTGTGAIALALACERPDCEVTA 138
Cdd:TIGR03704 36 RRVAGLPLEHVLGWAEFCGLRIAVDPGVFVPRRRTEFLVDEAAALARPRSGTlvVVDLCCGSGAVGAALAAALDGIELHA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 139 VDRMPDAVALAIRNaehLAIRNVRILQSCWFSALSGQ---QFDMIVSNPPYIDAQDPHLSEGDVRF-EPRSALVADENGM 214
Cdd:TIGR03704 116 ADIDPAAVRCARRN---LADAGGTVHEGDLYDALPTAlrgRVDILAANAPYVPTDAIALMPPEARDhEPRVALDGGADGL 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 812479181 215 ADLTHIIDNACQMLTPGGFLLLEHGWRQGEAVRAAFRRSGY-TDVETCRD 263
Cdd:TIGR03704 193 DVLRRVAAGAPDWLAPGGHLLVETSERQAPLAVEAFARAGLiARVASSEE 242
|
|
| RsmC |
COG2813 |
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ... |
112-236 |
1.81e-23 |
|
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 442062 [Multi-domain] Cd Length: 191 Bit Score: 94.10 E-value: 1.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 112 RILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGQQFDMIVSNPPYidaqd 191
Cdd:COG2813 52 RVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGVPDGSFDLILSNPPF----- 126
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 812479181 192 pHlsegdvrfeprsalvADENGMADLTH-IIDNACQMLTPGGFLLL 236
Cdd:COG2813 127 -H---------------AGRAVDKEVAHaLIADAARHLRPGGELWL 156
|
|
| PRK14967 |
PRK14967 |
putative methyltransferase; Provisional |
91-238 |
1.74e-21 |
|
putative methyltransferase; Provisional
Pssm-ID: 184931 [Multi-domain] Cd Length: 223 Bit Score: 89.73 E-value: 1.74e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 91 PRPDTECLVEQALARLPVKTCRILDLGTGTGAIALAlACERPDCEVTAVDRMPDAVALAIRNAEhLAIRNVRILQSCWFS 170
Cdd:PRK14967 18 PQEDTQLLADALAAEGLGPGRRVLDLCTGSGALAVA-AAAAGAGSVTAVDISRRAVRSARLNAL-LAGVDVDVRRGDWAR 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 812479181 171 ALSGQQFDMIVSNPPYIdaqdPHLSEGDVRFEPRSALVADENGMADLTHIIDNACQMLTPGGFLLLEH 238
Cdd:PRK14967 96 AVEFRPFDVVVSNPPYV----PAPPDAPPSRGPARAWDAGPDGRAVLDRLCDAAPALLAPGGSLLLVQ 159
|
|
| MTS |
pfam05175 |
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ... |
112-236 |
8.42e-17 |
|
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.
Pssm-ID: 428349 [Multi-domain] Cd Length: 170 Bit Score: 75.70 E-value: 8.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 112 RILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGQQFDMIVSNPPYIDAQD 191
Cdd:pfam05175 34 KVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVEDGKFDLIISNPPFHAGLA 113
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 812479181 192 PHLSegdvrfeprsalVADEngmadlthIIDNACQMLTPGGFLLL 236
Cdd:pfam05175 114 TTYN------------VAQR--------FIADAKRHLRPGGELWI 138
|
|
| PRK14968 |
PRK14968 |
putative methyltransferase; Provisional |
91-236 |
1.02e-16 |
|
putative methyltransferase; Provisional
Pssm-ID: 237872 [Multi-domain] Cd Length: 188 Bit Score: 76.09 E-value: 1.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 91 PRPDTECLVEQALARlpvKTCRILDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLAIRN--VRILQSCW 168
Cdd:PRK14968 8 PAEDSFLLAENAVDK---KGDRVLEVGTGSGIVAIVAA--KNGKKVVGVDINPYAVECAKCNAKLNNIRNngVEVIRSDL 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 812479181 169 FSALSGQQFDMIVSNPPYIdaqdPHLSEGDVRFEPRSALVADENGMADLTHIIDNACQMLTPGGFLLL 236
Cdd:PRK14968 83 FEPFRGDKFDVILFNPPYL----PTEEEEEWDDWLNYALSGGKDGREVIDRFLDEVGRYLKPGGRILL 146
|
|
| PrmC_N |
pfam17827 |
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ... |
6-73 |
4.73e-16 |
|
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.
Pssm-ID: 436073 [Multi-domain] Cd Length: 71 Bit Score: 70.97 E-value: 4.73e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 6 WLHEAVNQLRDS--DSPRRDAEILLEYVTGKRRTYIMAFGETPLTDVQQQQLAELLQRRKQGEPIAYLTG 73
Cdd:pfam17827 2 ALRWASSRLKEAgiESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
|
|
| AdoMet_MTases |
cd02440 |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
112-186 |
5.28e-15 |
|
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).
Pssm-ID: 100107 [Multi-domain] Cd Length: 107 Bit Score: 69.38 E-value: 5.28e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 812479181 112 RILDLGTGTGAIALALAcERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSAL--SGQQFDMIVSNPPY 186
Cdd:cd02440 1 RVLDLGCGTGALALALA-SGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPpeADESFDVIISDPPL 76
|
|
| PRK08287 |
PRK08287 |
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase; |
102-237 |
1.90e-13 |
|
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
Pssm-ID: 181354 Cd Length: 187 Bit Score: 66.95 E-value: 1.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 102 ALARLPVKTCR-ILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALSGqQFDMI 180
Cdd:PRK08287 23 ALSKLELHRAKhLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGNIDIIPGEAPIELPG-KADAI 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 812479181 181 vsnppYIDAQDPHLSEgdvrfeprsalvadengmadlthIIDNACQMLTPGG-----FLLLE 237
Cdd:PRK08287 102 -----FIGGSGGNLTA-----------------------IIDWSLAHLHPGGrlvltFILLE 135
|
|
| Methyltransf_31 |
pfam13847 |
Methyltransferase domain; This family appears to have methyltransferase activity. |
111-244 |
3.88e-13 |
|
Methyltransferase domain; This family appears to have methyltransferase activity.
Pssm-ID: 463998 [Multi-domain] Cd Length: 150 Bit Score: 65.52 E-value: 3.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 111 CRILDLGTGTGAIALALACE-RPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFS---ALSGQQFDMIVSNppy 186
Cdd:pfam13847 5 MRVLDLGCGTGHLSFELAEElGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEElpeLLEDDKFDVVISN--- 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 812479181 187 idaqdphlsegdvrfeprSALvadeNGMADLTHIIDNACQMLTPGGFLLLEHGWRQGE 244
Cdd:pfam13847 82 ------------------CVL----NHIPDPDKVLQEILRVLKPGGRLIISDPDSLAE 117
|
|
| UbiG |
COG2227 |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ... |
99-237 |
2.08e-11 |
|
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis
Pssm-ID: 441829 [Multi-domain] Cd Length: 126 Bit Score: 60.03 E-value: 2.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 99 VEQALARLPVKTCRILDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLairNVRILQSCWFS-ALSGQQF 177
Cdd:COG2227 14 LAALLARLLPAGGRVLDVGCGTGRLALALA--RRGADVTGVDISPEALEIARERAAEL---NVDFVQGDLEDlPLEDGSF 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 178 DMIVSNppyidaqdphlsegDVrFEPrsalvadengMADLTHIIDNACQMLTPGGFLLLE 237
Cdd:COG2227 89 DLVICS--------------EV-LEH----------LPDPAALLRELARLLKPGGLLLLS 123
|
|
| UbiE |
COG2226 |
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ... |
100-256 |
4.04e-11 |
|
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 441828 [Multi-domain] Cd Length: 143 Bit Score: 59.62 E-value: 4.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 100 EQALARLPVKTC-RILDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLAIrNVRILQSCWFS-ALSGQQF 177
Cdd:COG2226 12 EALLAALGLRPGaRVLDLGCGTGRLALALA--ERGARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDlPFPDGSF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 178 DMIVSNppyidaqdphlsegdvrfeprSALvadeNGMADLTHIIDNACQMLTPGG-FLLLEHGWRQGEAVRAAFRRSGYT 256
Cdd:COG2226 89 DLVISS---------------------FVL----HHLPDPERALAEIARVLKPGGrLVVVDFSPPDLAELEELLAEAGFE 143
|
|
| TrmA |
COG2265 |
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ... |
95-185 |
6.05e-11 |
|
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 441866 [Multi-domain] Cd Length: 377 Bit Score: 62.12 E-value: 6.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 95 TECLVEQALARL-PVKTCRILDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCWFSALS 173
Cdd:COG2265 218 AEALYAAALEWLdLTGGERVLDLYCGVGTFALPLA--RRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLP 295
|
90
....*....|....*.
gi 812479181 174 ----GQQFDMIVSNPP 185
Cdd:COG2265 296 ellwGGRPDVVVLDPP 311
|
|
| Tam |
COG4106 |
Trans-aconitate methyltransferase [Energy production and conversion]; |
112-238 |
9.14e-11 |
|
Trans-aconitate methyltransferase [Energy production and conversion];
Pssm-ID: 443282 [Multi-domain] Cd Length: 100 Bit Score: 57.53 E-value: 9.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 112 RILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQscwFSAlsGQQFDMIVSNppyidaqd 191
Cdd:COG4106 4 RVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVRFVVADLRD---LDP--PEPFDLVVSN-------- 70
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 812479181 192 phlsegdvrfeprSALvadeNGMADLTHIIDNACQMLTPGGFLLLEH 238
Cdd:COG4106 71 -------------AAL----HWLPDHAALLARLAAALAPGGVLAVQV 100
|
|
| SmtA |
COG0500 |
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ... |
101-237 |
4.00e-10 |
|
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];
Pssm-ID: 440266 [Multi-domain] Cd Length: 199 Bit Score: 58.00 E-value: 4.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 101 QALARLPvKTCRILDLGTGTGAIALALAcERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQS--CWFSALSGQQFD 178
Cdd:COG0500 19 ALLERLP-KGGRVLDLGCGTGRNLLALA-ARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVAdlAELDPLPAESFD 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 812479181 179 MIVSNpPYIDAQDPhlsegdvrfeprsalvadengmADLTHIIDNACQMLTPGGFLLLE 237
Cdd:COG0500 97 LVVAF-GVLHHLPP----------------------EEREALLRELARALKPGGVLLLS 132
|
|
| PrmA |
COG2264 |
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis]; |
97-263 |
8.97e-10 |
|
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441865 [Multi-domain] Cd Length: 284 Bit Score: 57.88 E-value: 8.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 97 CLveQALARLPVKTCRILDLGTGTG--AIALALaceRPDCEVTAVDRMPDAVALAIRNAEhlaiRN-----VRILQScwf 169
Cdd:COG2264 138 CL--EALEKLLKPGKTVLDVGCGSGilAIAAAK---LGAKRVLAVDIDPVAVEAARENAE----LNgvedrIEVVLG--- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 170 SALSGQQFDMIVSNppyidaqdphlsegdvrfeprsaLVADEngmadLTHIIDNACQMLTPGGFL----LLEHgwrQGEA 245
Cdd:COG2264 206 DLLEDGPYDLVVAN-----------------------ILANP-----LIELAPDLAALLKPGGYLilsgILEE---QADE 254
|
170
....*....|....*...
gi 812479181 246 VRAAFRRSGYTDVETCRD 263
Cdd:COG2264 255 VLAAYEAAGFELVERRER 272
|
|
| Methyltransf_25 |
pfam13649 |
Methyltransferase domain; This family appears to be a methyltransferase domain. |
113-183 |
1.34e-09 |
|
Methyltransferase domain; This family appears to be a methyltransferase domain.
Pssm-ID: 463945 [Multi-domain] Cd Length: 96 Bit Score: 54.11 E-value: 1.34e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 812479181 113 ILDLGTGTGAIALALAcERPDCEVTAVDRMPDAVALAIRNAEHLAIrNVRILQsCWFSALS--GQQFDMIVSN 183
Cdd:pfam13649 1 VLDLGCGTGRLTLALA-RRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQ-GDAEDLPfpDGSFDLVVSS 70
|
|
| CobL |
COG2242 |
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ... |
102-165 |
2.56e-09 |
|
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 441843 [Multi-domain] Cd Length: 403 Bit Score: 57.10 E-value: 2.56e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 812479181 102 ALARL-PVKTCRILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQ 165
Cdd:COG2242 239 TLAKLaLRPGDVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVPNVEVVE 303
|
|
| Cfa |
COG2230 |
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ... |
98-182 |
1.05e-08 |
|
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];
Pssm-ID: 441831 [Multi-domain] Cd Length: 158 Bit Score: 53.01 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 98 LVEQALARLPVK-TCRILDLGTGTGAIALALAcERPDCEVTAVDRMPDAVALAIRNAEHLAIRN-VRILQSCWFSALSGQ 175
Cdd:COG2230 39 KLDLILRKLGLKpGMRVLDIGCGWGGLALYLA-RRYGVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDLPADG 117
|
....*..
gi 812479181 176 QFDMIVS 182
Cdd:COG2230 118 QFDAIVS 124
|
|
| COG2263 |
COG2263 |
Predicted RNA methylase [General function prediction only]; |
112-210 |
2.05e-08 |
|
Predicted RNA methylase [General function prediction only];
Pssm-ID: 441864 [Multi-domain] Cd Length: 199 Bit Score: 52.98 E-value: 2.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 112 RILDLGTGTGAIALALACERPDcEVTAVDRMPDAVALAIRNAEHLAiRNVRILQSCWFSALSGQQFDMIVSNPPYiDAQD 191
Cdd:COG2263 48 TVLDLGCGTGMLAIGAALLGAK-KVVGVDIDPEALEIARENAERLG-VRVDFIRADVTRIPLGGSVDTVVMNPPF-GAQR 124
|
90
....*....|....*....
gi 812479181 192 PHLsegDVRFEPRSALVAD 210
Cdd:COG2263 125 RHA---DRPFLEKALEIAA 140
|
|
| rsmC |
PRK09489 |
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC; |
112-188 |
4.72e-07 |
|
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
Pssm-ID: 181902 [Multi-domain] Cd Length: 342 Bit Score: 50.32 E-value: 4.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 112 RILDLGTGTGAIALALACERPDCEVTavdrMPDAVALAIRNAEH-LAIRNV--RILQSCWFSALSGQqFDMIVSNPPYID 188
Cdd:PRK09489 199 KVLDVGCGAGVLSAVLARHSPKIRLT----LSDVSAAALESSRAtLAANGLegEVFASNVFSDIKGR-FDMIISNPPFHD 273
|
|
| TrmR |
COG4122 |
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ... |
101-271 |
6.51e-07 |
|
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 443298 Cd Length: 173 Bit Score: 48.26 E-value: 6.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 101 QALARLpVKTCRILDLGTGTG--AIALALACeRPDCEVTAVDRMPDAVALAIRN------AEHLAIRNVRILQscWFSAL 172
Cdd:COG4122 9 YLLARL-LGAKRILEIGTGTGysTLWLARAL-PDDGRLTTIEIDPERAAIARENfaraglADRIRLILGDALE--VLPRL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 173 SGQQFDMIvsnppYIDAqDPHlsegdvrfeprsalvadengmaDLTHIIDNACQMLTPGGFLLLEHGWRQGEAVRAAFRR 252
Cdd:COG4122 85 ADGPFDLV-----FIDA-DKS----------------------NYPDYLELALPLLRPGGLIVADNVLWHGRVADPARRD 136
|
170
....*....|....*....
gi 812479181 253 sgyTDVETCRDYggNERVA 271
Cdd:COG4122 137 ---PSTRAIREF--NEYLR 150
|
|
| RsmD |
COG0742 |
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ... |
111-265 |
2.28e-06 |
|
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440505 [Multi-domain] Cd Length: 183 Bit Score: 47.00 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 111 CRILDLGTGTGAIAL-ALA--CERpdceVTAVDRMPDAVALAIRNAEHL-AIRNVRILQS---CWFSALSGQQFDMIVSN 183
Cdd:COG0742 43 ARVLDLFAGSGALGLeALSrgAAS----VVFVEKDRKAAAVIRKNLEKLgLEDRARVIRGdalRFLKRLAGEPFDLVFLD 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 184 PPYidaqdphlsegdvrfeprsalvADENGMADLTHIIDNacQMLTPGGFLLLEHGWRQGEAVRAAfrrsGYTDVETcRD 263
Cdd:COG0742 119 PPY----------------------AKGLLEKALELLAEN--GLLAPGGLIVVEHSKREELPELPA----GLELLKE-RK 169
|
..
gi 812479181 264 YG 265
Cdd:COG0742 170 YG 171
|
|
| PRK06202 |
PRK06202 |
hypothetical protein; Provisional |
100-183 |
4.62e-06 |
|
hypothetical protein; Provisional
Pssm-ID: 180466 [Multi-domain] Cd Length: 232 Bit Score: 46.53 E-value: 4.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 100 EQALARLPVKTCRILDLGTGTGAIALALAC----ERPDCEVTAVDRMPDAVALAIRNAehlAIRNVRILQsCWFSALS-- 173
Cdd:PRK06202 51 LLRPALSADRPLTLLDIGCGGGDLAIDLARwarrDGLRLEVTAIDPDPRAVAFARANP---RRPGVTFRQ-AVSDELVae 126
|
90
....*....|
gi 812479181 174 GQQFDMIVSN 183
Cdd:PRK06202 127 GERFDVVTSN 136
|
|
| prmA |
PRK00517 |
50S ribosomal protein L11 methyltransferase; |
97-260 |
6.14e-06 |
|
50S ribosomal protein L11 methyltransferase;
Pssm-ID: 234786 [Multi-domain] Cd Length: 250 Bit Score: 46.30 E-value: 6.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 97 CLveQALARLPVKTCRILDLGTGTG--AIALA-LACErpdcEVTAVDRMPDAVALAIRNAEhlaiRN-VRILqscwFSAL 172
Cdd:PRK00517 109 CL--EALEKLVLPGKTVLDVGCGSGilAIAAAkLGAK----KVLAVDIDPQAVEAARENAE----LNgVELN----VYLP 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 173 SGQ-QFDMIVSNppyIDAqDPHLsegdvrfeprsalvadengmadltHIIDNACQMLTPGGFLLL----EhgwRQGEAVR 247
Cdd:PRK00517 175 QGDlKADVIVAN---ILA-NPLL------------------------ELAPDLARLLKPGGRLILsgilE---EQADEVL 223
|
170
....*....|...
gi 812479181 248 AAFRRSGYTDVET 260
Cdd:PRK00517 224 EAYEEAGFTLDEV 236
|
|
| PRK07402 |
PRK07402 |
precorrin-6Y C5,15-methyltransferase subunit CbiT; |
105-165 |
2.41e-05 |
|
precorrin-6Y C5,15-methyltransferase subunit CbiT;
Pssm-ID: 180961 Cd Length: 196 Bit Score: 44.22 E-value: 2.41e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 812479181 105 RLPVKTCrILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQ 165
Cdd:PRK07402 37 RLEPDSV-LWDIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKNVEVIE 96
|
|
| COG4976 |
COG4976 |
Predicted methyltransferase, contains TPR repeat [General function prediction only]; |
98-254 |
3.44e-05 |
|
Predicted methyltransferase, contains TPR repeat [General function prediction only];
Pssm-ID: 444001 [Multi-domain] Cd Length: 181 Bit Score: 43.45 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 98 LVEQALARLP-VKTCRILDLGTGTGAIALALAcERPDcEVTAVDRMPDAVALAIRNA--EHLAIRNVRILQScwfsalSG 174
Cdd:COG4976 34 LAEELLARLPpGPFGRVLDLGCGTGLLGEALR-PRGY-RLTGVDLSEEMLAKAREKGvyDRLLVADLADLAE------PD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 175 QQFDMIVSNppyidaqdphlsegDVrfeprsaLVAdengMADLTHIIDNACQMLTPGGFLLLE--------HGWRQGEAV 246
Cdd:COG4976 106 GRFDLIVAA--------------DV-------LTY----LGDLAAVFAGVARALKPGGLFIFSvedadgsgRYAHSLDYV 160
|
....*...
gi 812479181 247 RAAFRRSG 254
Cdd:COG4976 161 RDLLAAAG 168
|
|
| Methyltransf_12 |
pfam08242 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
114-234 |
4.21e-05 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 400515 [Multi-domain] Cd Length: 98 Bit Score: 41.58 E-value: 4.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 114 LDLGTGTGAIALALACERPDCEVTAVDRMPDAVALA---IRNAEHLAIRNVRILQsCWFSALSGQQFDMIVSNppyidaq 190
Cdd:pfam08242 1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAArerLAALGLLNAVRVELFQ-LDLGELDPGSFDVVVAS------- 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 812479181 191 dphlsegdvrfeprSALVAdengMADLTHIIDNACQMLTPGGFL 234
Cdd:pfam08242 73 --------------NVLHH----LADPRAVLRNIRRLLKPGGVL 98
|
|
| PRK15001 |
PRK15001 |
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG; |
113-186 |
4.45e-05 |
|
23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG;
Pssm-ID: 184963 [Multi-domain] Cd Length: 378 Bit Score: 44.25 E-value: 4.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 113 ILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEhlaiRNV-RILQSCWF---SALSGQQ---FDMIVSNPP 185
Cdd:PRK15001 232 IVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVE----TNMpEALDRCEFminNALSGVEpfrFNAVLCNPP 307
|
.
gi 812479181 186 Y 186
Cdd:PRK15001 308 F 308
|
|
| Cons_hypoth95 |
pfam03602 |
Conserved hypothetical protein 95; |
111-238 |
6.97e-05 |
|
Conserved hypothetical protein 95;
Pssm-ID: 427391 [Multi-domain] Cd Length: 179 Bit Score: 42.61 E-value: 6.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 111 CRILDLGTGTGAIALALACeRPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQSCW--FSALSGQ--QFDMIVSNPPY 186
Cdd:pfam03602 43 ARVLDLFAGSGALGLEALS-RGAKRVTLVEKDKRAVQILKENLQLLGLPGAVLVMDALlaLLRLAGKgpVFDIVFLDPPY 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 812479181 187 idaqdphlseGDVRFEPRSALVADEngmadlthiidnacQMLTPGGFLLLEH 238
Cdd:pfam03602 122 ----------AKGLIEEVLDLLAEK--------------GWLKPNALIYVET 149
|
|
| RlmK |
COG1092 |
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ... |
112-254 |
8.56e-05 |
|
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification
Pssm-ID: 440709 [Multi-domain] Cd Length: 392 Bit Score: 43.25 E-value: 8.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 112 RILDLGTGTGAIALALA---CErpdcEVTAVDRMPDAVALAIRNAE--HLAIRnVRILQS-CwFSAL-----SGQQFDMI 180
Cdd:COG1092 219 RVLNLFSYTGGFSVHAAaggAK----SVTSVDLSATALEWAKENAAlnGLDDR-HEFVQAdA-FDWLrelarEGERFDLI 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 181 VSNPPyidaqdphlsegdvRFEPRSAlvADENGMADLTHIIDNACQMLTPGGFLLL--------EHGWRqgEAVRAAFRR 252
Cdd:COG1092 293 ILDPP--------------AFAKSKK--DLFDAQRDYKDLNRLALKLLAPGGILVTsscsrhfsLDLFL--EILARAARD 354
|
..
gi 812479181 253 SG 254
Cdd:COG1092 355 AG 356
|
|
| Pcm |
COG2518 |
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ... |
101-165 |
1.00e-04 |
|
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 442008 [Multi-domain] Cd Length: 197 Bit Score: 42.38 E-value: 1.00e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 812479181 101 QALArlPVKTCRILDLGTGTG---AIALALACErpdceVTAVDRMPDAVALAIRNAEHLAIRNVRILQ 165
Cdd:COG2518 60 EALD--LKPGDRVLEIGTGSGyqaAVLARLAGR-----VYSVERDPELAERARERLAALGYDNVTVRV 120
|
|
| RsmG |
COG0357 |
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ... |
101-182 |
1.85e-04 |
|
16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) [Translation, ribosomal structure and biogenesis]; 16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B) is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 440126 Cd Length: 211 Bit Score: 41.68 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 101 QALARLPVKTCRILDLGTGTG--AIALALAceRPDCEVTAVDRMP---DAVALAIRnaeHLAIRNVRILQSCWFSALSGQ 175
Cdd:COG0357 59 ALLPLLPKEGARVLDVGSGAGfpGIPLAIA--RPDLQVTLVDSLGkkiAFLREVVR---ELGLKNVTVVHGRAEELAPRE 133
|
....*..
gi 812479181 176 QFDMIVS 182
Cdd:COG0357 134 KFDVVTA 140
|
|
| Rsm22 |
COG5459 |
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ... |
102-181 |
2.25e-04 |
|
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins
Pssm-ID: 444210 [Multi-domain] Cd Length: 306 Bit Score: 41.86 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 102 ALARLPVKTCRILDLGTGTGAIALALACERPDC-EVTAVDRMPDAVALA---IRNAEHLAIRNVRILQSCWFSALSGQQF 177
Cdd:COG5459 73 AEAGPDFAPLTVLDVGAGPGTAAWAAADAWPSLlDATLLERSAAALALGrrlARAAANPALETAEWRLADLAAALPAPPA 152
|
....
gi 812479181 178 DMIV 181
Cdd:COG5459 153 DLVV 156
|
|
| Methyltransf_4 |
pfam02390 |
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ... |
113-193 |
5.32e-04 |
|
Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.
Pssm-ID: 367068 Cd Length: 173 Bit Score: 39.97 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 113 ILDLGTGTGAIALALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRILQS----CWFSALSGQQFDMIVSNPPyid 188
Cdd:pfam02390 5 FLEIGCGMGGFLVAMAKANPDKNFIGIEIRVPGVAKALKKIDALGLQNLRILCGnaldVLPNYFPPGSLQKIFINFP--- 81
|
....*
gi 812479181 189 aqDPH 193
Cdd:pfam02390 82 --DPW 84
|
|
| rumB |
PRK03522 |
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC; |
115-185 |
6.71e-04 |
|
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
Pssm-ID: 235128 [Multi-domain] Cd Length: 315 Bit Score: 40.62 E-value: 6.71e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 812479181 115 DLGTGTGAiaLALACERPDCEVTAVDRMPDAVALAIRNAEHLAIRNVRilqscwFSALSGQQF--------DMIVSNPP 185
Cdd:PRK03522 179 DLFCGVGG--FGLHCATPGMQLTGIEISAEAIACAKQSAAELGLTNVQ------FQALDSTQFataqgevpDLVLVNPP 249
|
|
| Trm5 |
COG2520 |
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ... |
112-265 |
1.41e-03 |
|
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification
Pssm-ID: 442010 [Multi-domain] Cd Length: 333 Bit Score: 39.46 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 112 RILDLGTGTGAIALALACERPdCEVTAVDRMPDAVALAIRNAE--HLAiRNVRILQ---SCWFSALSGqQFDMIVSNPPY 186
Cdd:COG2520 183 RVLDMFAGVGPFSIPIAKRSG-AKVVAIDINPDAVEYLKENIRlnKVE-DRVTPILgdaREVAPELEG-KADRIIMNLPH 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 187 IdaqdphlsegdvrfeprsalvADEngmadlthIIDNACQMLTPGGFLLL------EHGWRQG-EAVRAAFRRSGYT--- 256
Cdd:COG2520 260 S---------------------ADE--------FLDAALRALKPGGVIHYyeivpeEDPFERAeERIEEAAEEAGYEvei 310
|
170
....*....|
gi 812479181 257 -DVETCRDYG 265
Cdd:COG2520 311 lEKRRVKSYS 320
|
|
| pcm |
PRK00312 |
protein-L-isoaspartate(D-aspartate) O-methyltransferase; |
90-161 |
1.92e-03 |
|
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
Pssm-ID: 178974 [Multi-domain] Cd Length: 212 Bit Score: 38.65 E-value: 1.92e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 812479181 90 IPRPDTECLVEQALArlPVKTCRILDLGTGTG---AIaLALACERpdceVTAVDRMPDAVALAIRNAEHLAIRNV 161
Cdd:PRK00312 61 ISQPYMVARMTELLE--LKPGDRVLEIGTGSGyqaAV-LAHLVRR----VFSVERIKTLQWEAKRRLKQLGLHNV 128
|
|
| YhdJ |
COG0863 |
DNA modification methylase [Replication, recombination and repair]; |
168-256 |
2.31e-03 |
|
DNA modification methylase [Replication, recombination and repair];
Pssm-ID: 440623 Cd Length: 236 Bit Score: 38.37 E-value: 2.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 168 WFSALSGQQFDMIVSNPPYIDAQDPHLSEGDVRFEPrsalvADENGMADLTHIIDNACQMLTPGGFLLLEHGWRQGEAVR 247
Cdd:COG0863 10 VLKELPDESVDLIVTDPPYNLGKKYGLGRREIGNEL-----SFEEYLEFLREWLAECYRVLKPGGSLYVNIGDRYISRLI 84
|
....*....
gi 812479181 248 AAFRRSGYT 256
Cdd:COG0863 85 AALRDAGFK 93
|
|
| PrmA |
pfam06325 |
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ... |
97-252 |
3.07e-03 |
|
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.
Pssm-ID: 428888 [Multi-domain] Cd Length: 294 Bit Score: 38.40 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 97 CLveQALARLPVKTCRILDLGTGTGAIALA---LACErpdcEVTAVDRMPDAVALAIRNAEHLAIRNvrILQSCWFSALS 173
Cdd:pfam06325 151 CL--EALERLVKPGESVLDVGCGSGILAIAalkLGAK----KVVGVDIDPVAVRAAKENAELNGVEA--RLEVYLPGDLP 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 174 GQQFDMIVSNppyIdaqdphLSEGDVRFEPR-SALVADEnGMADLTHIIDNACQM----LTPgGFLLLEHgWRQGEAVRA 248
Cdd:pfam06325 223 KEKADVVVAN---I------LADPLIELAPDiYALVKPG-GYLILSGILKEQAQMvaeaYSQ-GFELITV-EHREEWVCI 290
|
....
gi 812479181 249 AFRR 252
Cdd:pfam06325 291 VGKK 294
|
|
| Methyltransf_16 |
pfam10294 |
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ... |
111-181 |
5.07e-03 |
|
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.
Pssm-ID: 313513 Cd Length: 172 Bit Score: 36.93 E-value: 5.07e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 812479181 111 CRILDLGTGTGAIALALACERPDCEVTAVDRmPDAVALAIRNAEHLAIRN---VRIL---QSCWFSALSGQQFDMIV 181
Cdd:pfam10294 48 LNVLELGSGTGLVGIAVALLLPGASVTITDL-EEALELLKKNIELNALSSkvvVKVLdwgENLPPDLFDGHPVDLIL 123
|
|
| PRK08317 |
PRK08317 |
hypothetical protein; Provisional |
92-154 |
5.77e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 181382 [Multi-domain] Cd Length: 241 Bit Score: 37.22 E-value: 5.77e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 812479181 92 RPDTECLVEQALARLPVKTC-RILDLGTGTGAIALALACE-RPDCEVTAVDRMPDAVALAIRNAE 154
Cdd:PRK08317 1 LPDFRRYRARTFELLAVQPGdRVLDVGCGPGNDARELARRvGPEGRVVGIDRSEAMLALAKERAA 65
|
|
| PRK15128 |
PRK15128 |
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI; |
104-235 |
6.02e-03 |
|
23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI;
Pssm-ID: 185082 [Multi-domain] Cd Length: 396 Bit Score: 37.89 E-value: 6.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 104 ARLPVKTCRILDLGTGTGAIALAL---ACErpdcEVTAVDRMPDAVALAIRNAE--HLAIRNVRILQSCWFSAL-----S 173
Cdd:PRK15128 215 TRRYVENKRVLNCFSYTGGFAVSAlmgGCS----QVVSVDTSQEALDIARQNVElnKLDLSKAEFVRDDVFKLLrtyrdR 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 812479181 174 GQQFDMIVSNPPyidaqdphlsegdvRF-EPRSALVADENGMADLTHIidnACQMLTPGGFLL 235
Cdd:PRK15128 291 GEKFDVIVMDPP--------------KFvENKSQLMGACRGYKDINML---AIQLLNPGGILL 336
|
|
| Methyltransf_11 |
pfam08241 |
Methyltransferase domain; Members of this family are SAM dependent methyltransferases. |
114-162 |
6.20e-03 |
|
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
Pssm-ID: 462406 [Multi-domain] Cd Length: 94 Bit Score: 35.33 E-value: 6.20e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 812479181 114 LDLGTGTGAIALALAceRPDCEVTAVDRMPDAVALAIRNAEHLAIRNVR 162
Cdd:pfam08241 1 LDVGCGTGLLTELLA--RLGARVTGVDISPEMLELAREKAPREGLTFVV 47
|
|
| HsdM |
COG0286 |
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms]; |
91-232 |
6.56e-03 |
|
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
Pssm-ID: 440055 [Multi-domain] Cd Length: 243 Bit Score: 37.09 E-value: 6.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 91 PRPDTECLVEQALarlPVKTCRILDLGTGTGAIALALA--------CERPDCEVTAVDRMPDAVALAIRNaehLAIRNV- 161
Cdd:COG0286 28 PREVVRLMVELLD---PKPGETVYDPACGSGGFLVEAAeylkehggDERKKLSLYGQEINPTTYRLAKMN---LLLHGIg 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 812479181 162 --RILQSCWFSALSGQ--QFDMIVSNPPYIDAQDPHLSEGDvrFEPRSALVADENGMAD---LTHIIdnacQMLTPGG 232
Cdd:COG0286 102 dpNIELGDTLSNDGDEleKFDVVLANPPFGGKWKKEELKDD--LLGRFGYGLPPKSNADllfLQHIL----SLLKPGG 173
|
|
| RsmA |
COG0030 |
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ... |
107-186 |
6.85e-03 |
|
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification
Pssm-ID: 439801 [Multi-domain] Cd Length: 270 Bit Score: 37.03 E-value: 6.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479181 107 PVKTCRILDLGTGTGAIALALAcERPDcEVTAVDRMPDAVALAirnAEHLAIR-NVRILQS----CWFSALSGQQFDMIV 181
Cdd:COG0030 35 ITPGDTVLEIGPGLGALTRALL-ERAA-RVTAVEIDRRLAAIL---RETFAAYpNLTVIEGdalkVDLPALAAGEPLKVV 109
|
....*
gi 812479181 182 SNPPY 186
Cdd:COG0030 110 GNLPY 114
|
|
| |
