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Conserved domains on  [gi|812479177|emb|CGC87632|]
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isopentenyl monophosphate kinase [Salmonella enterica subsp. enterica serovar Typhi]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 17614445)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-283 2.92e-141

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


:

Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 399.19  E-value: 2.92e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177    1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRHDGEIHLLTPVTGVENEDNLIVRAARLLMKVASE 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKNFANS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   81 SgrLPAGSGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:TIGR00154  81 K--IKSLDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEII 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  161 TPV-NPPEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRS----------IDTLLKCEFSNDCEVIARKRFREVDAALSWL 229
Cdd:TIGR00154 159 TPFeDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAkewlkkisleCLQLLDSNGLNDLEKVALKRHTEVAQALNWL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 812479177  230 LEY--APSRLTGTGACVFAEFDTESCARQVLEQAPEWLNAFVAKGVNLSPLHRELL 283
Cdd:TIGR00154 239 LEYglAPERMSGSGPCVFALFDMESEAEQVLEQAPEWLNGFVAKGYNVSPIGRAML 294
 
Name Accession Description Interval E-value
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-283 2.92e-141

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 399.19  E-value: 2.92e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177    1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRHDGEIHLLTPVTGVENEDNLIVRAARLLMKVASE 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKNFANS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   81 SgrLPAGSGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:TIGR00154  81 K--IKSLDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEII 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  161 TPV-NPPEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRS----------IDTLLKCEFSNDCEVIARKRFREVDAALSWL 229
Cdd:TIGR00154 159 TPFeDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAkewlkkisleCLQLLDSNGLNDLEKVALKRHTEVAQALNWL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 812479177  230 LEY--APSRLTGTGACVFAEFDTESCARQVLEQAPEWLNAFVAKGVNLSPLHRELL 283
Cdd:TIGR00154 239 LEYglAPERMSGSGPCVFALFDMESEAEQVLEQAPEWLNGFVAKGYNVSPIGRAML 294
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-274 2.23e-122

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 350.58  E-value: 2.23e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   2 MTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRHDGEIHLLTPVTGV-ENEDNLIVRAARLLmkvASE 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVpTDEDNLVYRAARLL---QEA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  81 SGRLPagsGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:COG1947   78 TGIPP---GVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177 161 TPVNP-PEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRSIDTLLKC----------EFSNDCEVIARKRFREVDAALSWL 229
Cdd:COG1947  155 TPLPPlPELWLVLVKPGVGVSTAEVYRALDLTRDTPPPDIDALLAAlaagdaalaaLLRNDLEPVAFKLYPEIAEVLEAL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 812479177 230 LEYA--PSRLTGTGACVFAEFDTESCARQVLEQAPEWLNAFVAKGVN 274
Cdd:COG1947  235 LEAGalAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVARTLN 281
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-264 1.48e-53

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 175.81  E-value: 1.48e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPrhdGEIHLLTpVTG------VENEDNLIVRAARLL 74
Cdd:PRK14608   5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEP---AEALSLT-VSGpfaaglGDGDDNLVLRAARAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  75 MKVASEsgrlPAGSGAdISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAE 154
Cdd:PRK14608  81 RARVGP----GLPPGA-FHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177 155 GVGEILTPVNP-PEKWYLVAHPGVSIPTPVIFK------DPQLPRNT-PKRSIDTLLKC--EFSNDCEVIARKRFREVDA 224
Cdd:PRK14608 156 GIGEELTPLPGlPSLPAVLVNPGVPVATPDVFRalglrdGPPLPGAPdPLASADALLAAlaATRNDLEPPALALAPVIGE 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 812479177 225 ALSWLLEYAPSRLT---GTGACVFAEFDTESCARQ----VLEQAPEW 264
Cdd:PRK14608 236 VLAALRAQPGALLArmsGSGATCFALFADEAAAEAaaaaIAAAHPGW 282
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 91-148 1.12e-04

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 39.45  E-value: 1.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 812479177   91 DISIEKRLPMGGGLGGGSSNAATVLVALNHLW-----QCGLSIDELATLGLTLGADVPVFVRG 148
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGGRGGGMDVAASLYG 63
 
Name Accession Description Interval E-value
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 1-283 2.92e-141

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 399.19  E-value: 2.92e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177    1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRHDGEIHLLTPVTGVENEDNLIVRAARLLMKVASE 80
Cdd:TIGR00154   1 MRHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISVRSDDDIRLLKGDFDVPLEENLAYRAAQLLKNFANS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   81 SgrLPAGSGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:TIGR00154  81 K--IKSLDGVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEII 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  161 TPV-NPPEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRS----------IDTLLKCEFSNDCEVIARKRFREVDAALSWL 229
Cdd:TIGR00154 159 TPFeDPPEKWVVIAKPHVSVSTPVVYQAYKLPRNTPKRAkewlkkisleCLQLLDSNGLNDLEKVALKRHTEVAQALNWL 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 812479177  230 LEY--APSRLTGTGACVFAEFDTESCARQVLEQAPEWLNAFVAKGVNLSPLHRELL 283
Cdd:TIGR00154 239 LEYglAPERMSGSGPCVFALFDMESEAEQVLEQAPEWLNGFVAKGYNVSPIGRAML 294
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 2-274 2.23e-122

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 350.58  E-value: 2.23e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   2 MTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRHDGEIHLLTPVTGV-ENEDNLIVRAARLLmkvASE 80
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAGVpTDEDNLVYRAARLL---QEA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  81 SGRLPagsGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAEGVGEIL 160
Cdd:COG1947   78 TGIPP---GVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177 161 TPVNP-PEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRSIDTLLKC----------EFSNDCEVIARKRFREVDAALSWL 229
Cdd:COG1947  155 TPLPPlPELWLVLVKPGVGVSTAEVYRALDLTRDTPPPDIDALLAAlaagdaalaaLLRNDLEPVAFKLYPEIAEVLEAL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 812479177 230 LEYA--PSRLTGTGACVFAEFDTESCARQVLEQAPEWLNAFVAKGVN 274
Cdd:COG1947  235 LEAGalAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVARTLN 281
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 1-264 1.48e-53

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 175.81  E-value: 1.48e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   1 MMTHWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPrhdGEIHLLTpVTG------VENEDNLIVRAARLL 74
Cdd:PRK14608   5 PSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEP---AEALSLT-VSGpfaaglGDGDDNLVLRAARAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  75 MKVASEsgrlPAGSGAdISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAE 154
Cdd:PRK14608  81 RARVGP----GLPPGA-FHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177 155 GVGEILTPVNP-PEKWYLVAHPGVSIPTPVIFK------DPQLPRNT-PKRSIDTLLKC--EFSNDCEVIARKRFREVDA 224
Cdd:PRK14608 156 GIGEELTPLPGlPSLPAVLVNPGVPVATPDVFRalglrdGPPLPGAPdPLASADALLAAlaATRNDLEPPALALAPVIGE 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 812479177 225 ALSWLLEYAPSRLT---GTGACVFAEFDTESCARQ----VLEQAPEW 264
Cdd:PRK14608 236 VLAALRAQPGALLArmsGSGATCFALFADEAAAEAaaaaIAAAHPGW 282
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
7-246 1.64e-34

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 126.02  E-value: 1.64e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   7 SPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRHDGEIHLLTPVtgVENEDNLIVRAARLLMKVaseSGRLPA 86
Cdd:PRK14611   6 SPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKEHHTLEVKTSSPQ--IKEEENIVYKALRLFERY---TGIDIN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  87 GSgadISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAEGVGEILTPVNPP 166
Cdd:PRK14611  81 YS---IFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLEKP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177 167 --EKWYLVaHPGVSIPTPVIFKDPQLPRNTPKRSIDTLLKC----EFSNDCEVI-------ARKRFREVDAALSWL--LE 231
Cdd:PRK14611 158 isREITLV-YPNIKSSTGRVYSKVTKQILTNKEDLNIIISLlregEEKKIEEVIentlgeiALELYPEIKEVYRFLeyLG 236

                        250
                 ....*....|....*
gi 812479177 232 YAPsRLTGTGACVFA 246
Cdd:PRK14611 237 YKP-FVSGSGSSVYV 250
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 8-186 2.96e-27

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 107.28  E-value: 2.96e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   8 PAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPrhDGEIHLLTPVTGVE----NEDNLIVRAARLLmkvASESGR 83
Cdd:PRK03188   6 PAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTA--ADVLSVEVSGEGADqvptDESNLAWRAAELL---AEHVGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  84 LPagsGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRGHAAFAEGVGEILTPV 163
Cdd:PRK03188  81 AP---DVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPV 157

                        170       180
                 ....*....|....*....|....*.
gi 812479177 164 NPPEKWYLV---AHPGVSipTPVIFK 186
Cdd:PRK03188 158 LARGTFHWVlafADGGLS--TPAVFR 181
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 9-186 3.53e-20

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 87.32  E-value: 3.53e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   9 AKLNLFLYITGQRaDGYHTLQTLFQFL-DYGDTLHIEPRHDGEIHLLTPVtGVENEDNLIVRAARLLMKVASESGRLPAG 87
Cdd:PRK04181   7 AKVNIFLKILGKR-GNYHELISRFVLVkDLFDEIEFVPKSAESFELIGNF-DCPLEENIIYKAYQELKNKGFSNELIEFF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  88 SGADISIEKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSIDELATLGLTLGADVPVFVRG-HAAFAEGVGEILTPVN-- 164
Cdd:PRK04181  85 KKKAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGEIVEEFEee 164

                        170       180
                 ....*....|....*....|...
gi 812479177 165 PPE-KWYLvahPGVSIPTPVIFK 186
Cdd:PRK04181 165 ILNlEIFT---PNIFCSTKAVYK 184
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
7-260 1.07e-19

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 86.49  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   7 SPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTLHIEPRHDGEIHLLTpvtgveneDNLIVRAARLLMKVASESGRL-- 84
Cdd:PRK14613   3 SPAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVFELFS--------TNEIILEKRKLYDQVSERGDIkq 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  85 --------------PAGSGADISIEKRLPMGGGLGGGSSNAATVlvaLNHL--WQCGLSIDELATLGLTLGADVPVFVRG 148
Cdd:PRK14613  75 nilyktfikarslfPELPGVKIHLTKRISPAGGLGGGSTNAASL---LNFLfsWRNFFTSDEMQVFAKEIGSDVPFFLGE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177 149 HAAFAEGVGEILTPVNPPEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRS----------IDTL-------LKCEFSNDC 211
Cdd:PRK14613 152 GHAFVTGKGEIMEEIEVHKGQGILALTPQVMNTGEMYALLKKPLQESASQkngntlsedlISSLkvgdwvsLQGRLENDF 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 812479177 212 EVIARKRFREVDAALSWLLEYAPS--RLTGTGACVFAEFDTESCARQVLEQ 260
Cdd:PRK14613 232 EPVAFQLHPELGVLKDKFLEFGSSycSLTGSGSSMYGLVQGLEIQEELLPR 282
PRK01212 PRK01212
homoserine kinase; Provisional
 35-181 1.52e-05

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 45.52  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  35 LDYGDTLHIEPRHDGEIHLLTPVTGVE-------NEDNLIVRAARLLMKVASESGrlpagsGADISIEKRLPMggglggg 107
Cdd:PRK01212  26 LSLYDEVLVGDVVSVEAEFSIEVIGEGadklpldPEKNLVYQAALKFLEKLGKPP------GLRIELEKNIPLgrg--lg 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177 108 SSNAATV--LVALNHLWQCGLSIDEL---ATL--------------GLTLGADVPvfvrghaafaegvGEILTPVNPPEK 168
Cdd:PRK01212  98 SSAASIVagLVAANELAGLPLSKEELlqlATEgeghpdnvapallgGLVLALEEN-------------GVISVKIPVFDD 164

                        170
                 ....*....|....
gi 812479177 169 WYLV-AHPGVSIPT 181
Cdd:PRK01212 165 LKWVvAIPNIELST 178
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 91-148 1.12e-04

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 39.45  E-value: 1.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 812479177   91 DISIEKRLPMGGGLGGGSSNAATVLVALNHLW-----QCGLSIDELATLGLTLGADVPVFVRG 148
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFglplaKLALEAEELAGGGRGGGMDVAASLYG 63
PRK03926 PRK03926
mevalonate kinase; Provisional
 59-135 1.55e-03

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 39.27  E-value: 1.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 812479177  59 GVENEDNLIVRAARLLMKVASESgrlpagSGADISIEKRLPMGGGLGggSSNAATV--LVALNHLWQCGLSIDELATLG 135
Cdd:PRK03926  51 GKTGEKHPYVSAAIEKMREEADK------DGVTVSITSQIPVGSGLG--SSAAVTVatIGALNRLLGLGLSLEEIAKLG 121
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 188-267 2.46e-03

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 36.29  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  188 PQLPRNTPKRSIDTLLKCEFSNDCEVIARKRFREVDAALSWLLEY-APSRLTGT--GACVFAEFDTESCARQVLEQAPEW 264
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLEPLLVVGILPPELDELLEALLELgLGAKLSGSggGPTVFALFKDEDDAEEVARALREA 82


                  ...
gi 812479177  265 LNA 267
Cdd:pfam08544  83 GKK 85
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
4-204 4.13e-03

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 37.91  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177   4 HWPSPAKLNLFLYITGQRAD-GYHTLQTLFQFL-DYGDTLHIEP--RHDGEIHLLtpvtgveNEDNLIVRAARLLMKVAS 79
Cdd:PRK05905   2 KYKSYAKINLGLSIYKKCKKvTKHKLESIFILVeNVYDDIEIEKieKNIDDIHYF-------DETNEILVYSRLILVKTL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812479177  80 E--SGRLPAGSGADISIEKRLPMGGGLGGGSSNAAtvlVALNHLWQCG----LSIDELATlglTLGADVPVFVRGH-AAF 152
Cdd:PRK05905  75 EwlRDKYNIKNHFKIKIKKRIPIGSGLGSGSSNAA---VLMKWILEFEgineINYKDVVN---KLGSDIPFFLSGYkTAY 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 812479177 153 AEGVGEILTPV-NPPEKWYLVAHPGVSIPTPVIFKDPQLPRNTPKRSIDTLLK 204
Cdd:PRK05905 149 ISDYGSQVEDLiGQFKLTYKVIFMNVNVSTKKVFEKFDDNQHVIKNNFKTIIK 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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