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Conserved domains on  [gi|812534179|emb|CGA50183|]
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2-dehydro-3-deoxyphosphooctonate aldolase [Salmonella enterica subsp. enterica serovar Typhi]

Protein Classification

3-deoxy-8-phosphooctulonate synthase( domain architecture ID 10012268)

3-deoxy-8-phosphooctulonate synthase catalyzes the condensation reaction between arabinose 5-phosphate and phosphoenolpyruvate to synthesize 3-deoxy-D-manno-octulosonate-8-phosphate (KDO8P), the precursor of the 8-carbon sugar KDO, which is an essential component of gram-negative bacterial lipopolysaccharides

Gene Ontology:  GO:0019294|GO:0008676
SCOP:  4003245

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-274 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


:

Pssm-ID: 235363  Cd Length: 264  Bit Score: 526.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   9 GDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTF 88
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  89 GVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCDR 168
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 169 GANFGYDNLVVDMLGFSVMKKVsgNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDPANAK 248
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRET--GAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNAL 238

                        250       260
                 ....*....|....*....|....*.
gi 812534179 249 CDGPSALPLAKLEQFLTQIKAIDDLV 274
Cdd:PRK05198 239 SDGPNMLPLDKLEPLLEQLKAIDDLV 264
 
Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-274 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 235363  Cd Length: 264  Bit Score: 526.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   9 GDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTF 88
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  89 GVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCDR 168
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 169 GANFGYDNLVVDMLGFSVMKKVsgNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDPANAK 248
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRET--GAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNAL 238

                        250       260
                 ....*....|....*....|....*.
gi 812534179 249 CDGPSALPLAKLEQFLTQIKAIDDLV 274
Cdd:PRK05198 239 SDGPNMLPLDKLEPLLEQLKAIDDLV 264
KdsA COG2877
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope ...
 8-274 0e+00

3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 442124  Cd Length: 265  Bit Score: 511.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   8 IGDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQT 87
Cdd:COG2877    1 IGGIEVGNDKPLFLIAGPCVIESEDLALEIAEKLKEITDKLGIPYIFKASFDKANRSSIDSFRGPGLEEGLKILAEVKEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  88 FGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCD 167
Cdd:COG2877   81 FGVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVEKVREAGNDNILLTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 168 RGANFGYDNLVVDMLGFSVMKKvsGNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDPANA 247
Cdd:COG2877  161 RGTSFGYNNLVVDMRSLPIMRE--TGYPVVFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVDGLFMETHPDPDKA 238

                        250       260
                 ....*....|....*....|....*..
gi 812534179 248 KCDGPSALPLAKLEQFLTQIKAIDDLV 274
Cdd:COG2877  239 LSDGPNMLPLDKLEELLEQLKAIDELV 265
KDO8P_synth TIGR01362
3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate ...
 18-276 8.90e-163

3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 130429  Cd Length: 258  Bit Score: 452.20  E-value: 8.90e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   18 PFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTFGVKVITDVH 97
Cdd:TIGR01362   2 KFFLIAGPCVIESEDHALRVAEKLKELTSKLGVPFIFKSSFDKANRSSIHSFRGPGLEEGLKILQKVKEEFGVPILTDVH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   98 EASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCDRGANFGYDNL 177
Cdd:TIGR01362  82 ESSQCEPVAEVVDIIQIPAFLCRQTDLLVAAAKTGRIVNVKKGQFLSPWDMKNVVEKVLSTGNKNILLCERGTSFGYNNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  178 VVDMLGFSVMKKVsgNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDPANAKCDGPSALPL 257
Cdd:TIGR01362 162 VVDMRSLPIMREL--GCPVIFDATHSVQQPGGLGGASGGLREFVPTLARAAVAVGIDGLFMETHPDPKNAKSDGPNMLPL 239

                         250
                  ....*....|....*....
gi 812534179  258 AKLEQFLTQIKAIDDLVKS 276
Cdd:TIGR01362 240 SELEGLLEKLLAIDALTKS 258
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 4-276 5.74e-86

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 258.02  E-value: 5.74e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179    4 KVVNIGDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSsIHSYRGPGLEEGMKIFQE 83
Cdd:pfam00793   3 PISLKQDIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLKLIIIMRAYFEKPRTS-PVGFKGLGNDPDLNILFR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   84 LKQTFGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFH-EGGNDK 162
Cdd:pfam00793  82 IKDGLGLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLfLGVTKG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  163 VILCDRGANFGY--DNLVVDMLGFSVMKKVSGNSPVIFDVTHALQCRDpfgaasGGRRGQVTELARAGMAVGLAGLFLES 240
Cdd:pfam00793 162 NILCERGIRGGEgpNRNTLDVSAVAILKEETGHLPVMVDVSHANGRKD------GGRQPLVLPLAKAAIAVGIDGLMIEV 235

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 812534179  241 HPDPANAKCDGPSALPLAKLEQFLTQIKAIDDLVKS 276
Cdd:pfam00793 236 HPNPGNALSDGPQQLKYGKSETDACILWELTELLLE 271
BagF_FevY NF041229
phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;
63-263 5.48e-26

phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;


Pssm-ID: 469132 [Multi-domain]  Cd Length: 340  Bit Score: 104.73  E-value: 5.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  63 RSSIHSYRGPGlEEGMKIFQELKQTFGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGavinvkKPQF 142
Cdd:NF041229 129 RTSPYAFQGLG-EAGLKILADVRAETGLPIVTEVVDAHDVELVASYADMLQIGTRNAQNFALLQAVGDVG------KPVM 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 143 VSPGQMGNI------VDKFHEGGNDKVILCDRGANfGYDNLVVDMLGFSVMKKVSGNS--PVIFDVTHalqcrdpfgaaS 214
Cdd:NF041229 202 LKRGMSGTIeewlmaAEYVAQRGNLDIVLCERGIR-TFETATRNTLDIAAVPIVQRLShlPVIVDPSH-----------S 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 812534179 215 GGRRGQVTELARAGMAVGLAGLFLESHPDPANAKCDGPSALPLAKLEQF 263
Cdd:NF041229 270 GGRRDLVLPLTRAALAVGADGVIVDVHPDPRTALCDGPQALVHEDLEEL 318
 
Name Accession Description Interval E-value
PRK05198 PRK05198
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-274 0e+00

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 235363  Cd Length: 264  Bit Score: 526.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   9 GDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTF 88
Cdd:PRK05198   1 GDIEVGNDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKASFDKANRSSIHSFRGPGLEEGLKILQEVKETF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  89 GVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCDR 168
Cdd:PRK05198  81 GVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNIKKGQFLAPWDMKNVVDKVREAGNDKIILCER 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 169 GANFGYDNLVVDMLGFSVMKKVsgNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDPANAK 248
Cdd:PRK05198 161 GTSFGYNNLVVDMRGLPIMRET--GAPVIFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVAGLFIETHPDPDNAL 238

                        250       260
                 ....*....|....*....|....*.
gi 812534179 249 CDGPSALPLAKLEQFLTQIKAIDDLV 274
Cdd:PRK05198 239 SDGPNMLPLDKLEPLLEQLKAIDDLV 264
PRK12457 PRK12457
3-deoxy-8-phosphooctulonate synthase;
5-281 0e+00

3-deoxy-8-phosphooctulonate synthase;


Pssm-ID: 237105  Cd Length: 281  Bit Score: 522.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   5 VVNIGDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQEL 84
Cdd:PRK12457   3 VAISPGITVGNDLPFVLFGGINVLESLDFTLDVCGEYVEVTRKLGIPFVFKASFDKANRSSIHSYRGVGLDEGLRIFEEV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  85 KQTFGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVI 164
Cdd:PRK12457  83 KARFGVPVITDVHEVEQAAPVAEVADVLQVPAFLARQTDLVVAIAKTGKPVNIKKPQFMSPTQMKHVVSKCREAGNDRVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 165 LCDRGANFGYDNLVVDMLGFSVMKKVSGNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDP 244
Cdd:PRK12457 163 LCERGSSFGYDNLVVDMLGFRQMKRTTGDLPVIFDVTHSLQCRDPLGAASGGRRRQVLDLARAGMAVGLAGLFLEAHPDP 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 812534179 245 ANAKCDGPSALPLAKLEQFLTQIKAIDDLVKSFDELD 281
Cdd:PRK12457 243 DRARCDGPSALPLDQLEPFLSQVKALDDLVKSFPPLD 279
KdsA COG2877
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope ...
 8-274 0e+00

3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 442124  Cd Length: 265  Bit Score: 511.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   8 IGDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQT 87
Cdd:COG2877    1 IGGIEVGNDKPLFLIAGPCVIESEDLALEIAEKLKEITDKLGIPYIFKASFDKANRSSIDSFRGPGLEEGLKILAEVKEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  88 FGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCD 167
Cdd:COG2877   81 FGVPVLTDVHEPEQAAPVAEVVDVLQIPAFLCRQTDLLVAAAKTGKVVNVKKGQFLAPWDMKNVVEKVREAGNDNILLTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 168 RGANFGYDNLVVDMLGFSVMKKvsGNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDPANA 247
Cdd:COG2877  161 RGTSFGYNNLVVDMRSLPIMRE--TGYPVVFDATHSVQLPGGQGGSSGGQREFVPVLARAAVAVGVDGLFMETHPDPDKA 238

                        250       260
                 ....*....|....*....|....*..
gi 812534179 248 KCDGPSALPLAKLEQFLTQIKAIDDLV 274
Cdd:COG2877  239 LSDGPNMLPLDKLEELLEQLKAIDELV 265
KDO8P_synth TIGR01362
3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate ...
 18-276 8.90e-163

3-deoxy-8-phosphooctulonate synthase; This model describes 3-deoxy-8-phosphooctulonate synthase. Alternate names include 2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 130429  Cd Length: 258  Bit Score: 452.20  E-value: 8.90e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   18 PFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTFGVKVITDVH 97
Cdd:TIGR01362   2 KFFLIAGPCVIESEDHALRVAEKLKELTSKLGVPFIFKSSFDKANRSSIHSFRGPGLEEGLKILQKVKEEFGVPILTDVH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   98 EASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCDRGANFGYDNL 177
Cdd:TIGR01362  82 ESSQCEPVAEVVDIIQIPAFLCRQTDLLVAAAKTGRIVNVKKGQFLSPWDMKNVVEKVLSTGNKNILLCERGTSFGYNNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  178 VVDMLGFSVMKKVsgNSPVIFDVTHALQCRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPDPANAKCDGPSALPL 257
Cdd:TIGR01362 162 VVDMRSLPIMREL--GCPVIFDATHSVQQPGGLGGASGGLREFVPTLARAAVAVGIDGLFMETHPDPKNAKSDGPNMLPL 239

                         250
                  ....*....|....*....
gi 812534179  258 AKLEQFLTQIKAIDDLVKS 276
Cdd:TIGR01362 240 SELEGLLEKLLAIDALTKS 258
PLN03033 PLN03033
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
 9-275 9.80e-96

2-dehydro-3-deoxyphosphooctonate aldolase; Provisional


Pssm-ID: 178601  Cd Length: 290  Bit Score: 283.67  E-value: 9.80e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   9 GDIKVANdlPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTF 88
Cdd:PLN03033   9 NQLKAAE--PFFLLAGPNVIESEEHILRMAKHIKDISTKLGLPLVFKSSFDKANRTSSKSFRGPGMAEGLKILEKVKVAY 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  89 GVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFHEGGNDKVILCDR 168
Cdd:PLN03033  87 DLPIVTDVHESSQCEAVGKVADIIQIPAFLCRQTDLLVAAAKTGKIINIKKGQFCAPSVMRNSAEKVRLAGNPNVMVCER 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 169 GANFGYDNLVVDMLGFSVMKKvsGNSPVIFDVTHALQ-----CRDPFGAASGGRRGQVTELARAGMAVGLAGLFLESHPD 243
Cdd:PLN03033 167 GTMFGYNDLIVDPRNLEWMRE--ANCPVVADITHSLQqpagkKLDGGGVASGGLRELIPCIARTAVAVGVDGIFMEVHDD 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 812534179 244 PANAKCDGPSALPLAKLEQFLTQIKAIDDLVK 275
Cdd:PLN03033 245 PLSAPVDGPTQWPLRHLEELLEELIAIARVTK 276
DAHP_synth_1 pfam00793
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 4-276 5.74e-86

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


Pssm-ID: 395641  Cd Length: 271  Bit Score: 258.02  E-value: 5.74e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179    4 KVVNIGDIKVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSsIHSYRGPGLEEGMKIFQE 83
Cdd:pfam00793   3 PISLKQDIIIGKDDRLLVIAGPCSIEDPEAAMEYARRLKKLGAKLKLIIIMRAYFEKPRTS-PVGFKGLGNDPDLNILFR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   84 LKQTFGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFH-EGGNDK 162
Cdd:pfam00793  82 IKDGLGLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLfLGVTKG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  163 VILCDRGANFGY--DNLVVDMLGFSVMKKVSGNSPVIFDVTHALQCRDpfgaasGGRRGQVTELARAGMAVGLAGLFLES 240
Cdd:pfam00793 162 NILCERGIRGGEgpNRNTLDVSAVAILKEETGHLPVMVDVSHANGRKD------GGRQPLVLPLAKAAIAVGIDGLMIEV 235

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 812534179  241 HPDPANAKCDGPSALPLAKLEQFLTQIKAIDDLVKS 276
Cdd:pfam00793 236 HPNPGNALSDGPQQLKYGKSETDACILWELTELLLE 271
PRK08673 PRK08673
3-deoxy-7-phosphoheptulonate synthase; Reviewed
 5-275 6.90e-31

3-deoxy-7-phosphoheptulonate synthase; Reviewed


Pssm-ID: 181535 [Multi-domain]  Cd Length: 335  Bit Score: 117.68  E-value: 6.90e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   5 VVNIGDIKVANDLPFVLFGGMNVlESRDLAMRICEhyvtVTQKLGIPY----VFKAsfdkanRSSIHSYRGPGlEEGMKI 80
Cdd:PRK08673  81 VVKVGDVEIGGGKPVVIAGPCSV-ESEEQILEIAR----AVKEAGAQIlrggAFKP------RTSPYSFQGLG-EEGLKL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  81 FQELKQTFGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTgavinvKKPQFVSPGqMGNIVDKF----- 155
Cdd:PRK08673 149 LAEAREETGLPIVTEVMDPRDVELVAEYVDILQIGARNMQNFDLLKEVGKT------NKPVLLKRG-MSATIEEWlmaae 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 156 --HEGGNDKVILCDRG----ANFGYDNLvvDMLGFSVMKKVSgNSPVIFDVTHAlqcrdpfgaasGGRRGQVTELARAGM 229
Cdd:PRK08673 222 yiLAEGNPNVILCERGirtfETATRNTL--DLSAVPVIKKLT-HLPVIVDPSHA-----------TGKRDLVEPLALAAV 287

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 812534179 230 AVGLAGLFLESHPDPANAKCDGPSALPLAKLEQFLTQIKAIDDLVK 275
Cdd:PRK08673 288 AAGADGLIVEVHPDPEKALSDGPQSLTPEEFEELMKKLRAIAEALG 333
AroGA COG2876
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ...
 5-274 2.65e-30

3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 442123  Cd Length: 283  Bit Score: 114.78  E-value: 2.65e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   5 VVNIGDIKVANDlPFVLFGGMNVLESRDLAMRICEHYVTVTQKL---GipyVFKAsfdkanRSSIHSYRGPGlEEGMKIF 81
Cdd:COG2876   28 VVDVGGVKIGGG-ELVVIAGPCAVESEEQILETAKAVKAAGAKIlrgG---AFKP------RTSPYSFQGLG-EEGLKLL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  82 QELKQTFGVKVITDVHEASQAQPVADVVDVIQLPAflaR--Q-TDLVEAMAKTGavinvkKPQFVSPGqMGNIVDKF--- 155
Cdd:COG2876   97 AEAREETGLPVVTEVMDPRDVELVAEYADILQIGA---RnmQnFELLKEVGRTG------KPVLLKRG-LSATIEEWlma 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 156 ----HEGGNDKVILCDRG--------ANfgydnlVVDMLGFSVMKKVSgNSPVIFDVTHAlqcrdpfgaasGGRRGQVTE 223
Cdd:COG2876  167 aeyiLSEGNPNVILCERGirtfetatRN------TLDLSAVPVLKELT-HLPVIVDPSHA-----------TGRRDLVPP 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 812534179 224 LARAGMAVGLAGLFLESHPDPANAKCDGPSALPLAKLEQFLTQIKAIDDLV 274
Cdd:COG2876  229 MAKAAVAAGADGLMIEVHPDPEKALSDGPQSLTPEEFAELMEELRKLAEAV 279
BagF_FevY NF041229
phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;
63-263 5.48e-26

phospho-2-dehydro-3-deoxyheptonate aldolase BagF/FevY;


Pssm-ID: 469132 [Multi-domain]  Cd Length: 340  Bit Score: 104.73  E-value: 5.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  63 RSSIHSYRGPGlEEGMKIFQELKQTFGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGavinvkKPQF 142
Cdd:NF041229 129 RTSPYAFQGLG-EAGLKILADVRAETGLPIVTEVVDAHDVELVASYADMLQIGTRNAQNFALLQAVGDVG------KPVM 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 143 VSPGQMGNI------VDKFHEGGNDKVILCDRGANfGYDNLVVDMLGFSVMKKVSGNS--PVIFDVTHalqcrdpfgaaS 214
Cdd:NF041229 202 LKRGMSGTIeewlmaAEYVAQRGNLDIVLCERGIR-TFETATRNTLDIAAVPIVQRLShlPVIVDPSH-----------S 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 812534179 215 GGRRGQVTELARAGMAVGLAGLFLESHPDPANAKCDGPSALPLAKLEQF 263
Cdd:NF041229 270 GGRRDLVLPLTRAALAVGADGVIVDVHPDPRTALCDGPQALVHEDLEEL 318
PRK12595 PRK12595
bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed
 4-276 1.78e-21

bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed


Pssm-ID: 183614 [Multi-domain]  Cd Length: 360  Bit Score: 92.35  E-value: 1.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179   4 KVVNIGDIKVANDLPFVLFGGMNVlESRdlamricEHYVTVTQKL---GIPYVFKASFDKanRSSIHSYRGPGlEEGMKI 80
Cdd:PRK12595 105 TIVDVKGEVIGDGNQSFIFGPCSV-ESY-------EQVEAVAKALkakGLKLLRGGAFKP--RTSPYDFQGLG-VEGLKI 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  81 FQELKQTFGVKVITDVHEASQAQPVADVVDVIQLPAFLARQTDLVEAMAKTgavinvKKPQFVSPGQMGNIVDKFHEG-- 158
Cdd:PRK12595 174 LKQVADEYGLAVISEIVNPADVEVALDYVDVIQIGARNMQNFELLKAAGRV------NKPVLLKRGLSATIEEFIYAAey 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 159 ----GNDKVILCDRGANfGYDNLVVDMLGFS---VMKKVSgNSPVIFDVTHalqcrdpfgaaSGGRRGQVTELARAGMAV 231
Cdd:PRK12595 248 imsqGNGQIILCERGIR-TYEKATRNTLDISavpILKQET-HLPVMVDVTH-----------STGRRDLLLPTAKAALAI 314

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 812534179 232 GLAGLFLESHPDPANAKCDGPSALPLAKLEQFLTQIKAIDDLVKS 276
Cdd:PRK12595 315 GADGVMAEVHPDPAVALSDSAQQMDIPEFDRFLDELKPLANKLNA 359
PRK13396 PRK13396
3-deoxy-7-phosphoheptulonate synthase; Provisional
 63-275 1.54e-15

3-deoxy-7-phosphoheptulonate synthase; Provisional


Pssm-ID: 237376 [Multi-domain]  Cd Length: 352  Bit Score: 75.56  E-value: 1.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179  63 RSSIHSYRGPGlEEGMKIFQELKQTFGVKVITDVHEASQAQPVADVVDVIQLPAflaRQTDLVEAMAKTGAVinvKKPQF 142
Cdd:PRK13396 140 RTSPYAFQGHG-ESALELLAAAREATGLGIITEVMDAADLEKIAEVADVIQVGA---RNMQNFSLLKKVGAQ---DKPVL 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 812534179 143 VSPGQMGNIVDKFHE------GGNDKVILCDRGANFGYDNLVVDMLGFSVMkkvsgnsPVIFDVTHALQCRDPfgAASGG 216
Cdd:PRK13396 213 LKRGMAATIDEWLMAaeyilaAGNPNVILCERGIRTFDRQYTRNTLDLSVI-------PVLRSLTHLPIMIDP--SHGTG 283

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 812534179 217 RRGQVTELARAGMAVGLAGLFLESHPDPANAKCDGPSALPLAKLEQFLTQIKAIDDLVK 275
Cdd:PRK13396 284 KSEYVPSMAMAAIAAGTDSLMIEVHPNPAKALSDGPQSLTPDRFDRLMQELAVIGKTVG 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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