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Conserved domains on  [gi|813121957|emb|CFY30549|]
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anaerobic dimethyl sulfoxide reductase subunit B [Salmonella enterica subsp. enterica serovar Typhi]

Protein Classification

DmsB/YnfG family anaerobic dimethyl sulfoxide reductase iron-sulfur subunit( domain architecture ID 1007183)

DmsB/YnfG family anaerobic dimethyl sulfoxide reductase iron-sulfur subunit is the electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds

Gene Ontology:  GO:0051539|GO:0046872|GO:0009061|GO:0009389

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DMSO_dmsB super family cl31276
DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain ...
 3-131 1.31e-75

DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain B, of an enzyme called the anaerobic dimethyl sulfoxide reductase. Chains A and B are catalytic, while chain C is a membrane anchor.


The actual alignment was detected with superfamily member TIGR02951:

Pssm-ID: 131996 [Multi-domain]  Cd Length: 161  Bit Score: 221.53  E-value: 1.31e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957    3 QCGFYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGGSWVKEGESWHHDTFTYYLSIACNHCDEPVCVSGCPTGA 82
Cdd:TIGR02951   1 QYGFYVDQTRCSGCKTCQIACKDKNDLEVGVLFRRVYEYEGGGWTEEGEGFHPDVFAYYISISCNHCADPACVKNCPTGA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 813121957   83 MHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:TIGR02951  81 MYKREEDGLVLVDQDKCIGCRYCVWACPYGAPQYDPQQGVMGKCDGCYD 129
 
Name Accession Description Interval E-value
DMSO_dmsB TIGR02951
DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain ...
 3-131 1.31e-75

DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain B, of an enzyme called the anaerobic dimethyl sulfoxide reductase. Chains A and B are catalytic, while chain C is a membrane anchor.


Pssm-ID: 131996 [Multi-domain]  Cd Length: 161  Bit Score: 221.53  E-value: 1.31e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957    3 QCGFYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGGSWVKEGESWHHDTFTYYLSIACNHCDEPVCVSGCPTGA 82
Cdd:TIGR02951   1 QYGFYVDQTRCSGCKTCQIACKDKNDLEVGVLFRRVYEYEGGGWTEEGEGFHPDVFAYYISISCNHCADPACVKNCPTGA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 813121957   83 MHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:TIGR02951  81 MYKREEDGLVLVDQDKCIGCRYCVWACPYGAPQYDPQQGVMGKCDGCYD 129
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 5-131 1.10e-55

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 170.05  E-value: 1.10e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   5 GFYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGGSWvkegeswhHDTFTYYLSIACNHCDEPVCVSGCPTGAMH 84
Cdd:cd16371    1 GFYFDQERCIGCKACEIACKDKNDLPPGVNWRRVYEYEGGEF--------PEVFAYFLSMSCNHCENPACVKVCPTGAIT 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 813121957  85 KRkEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd16371   73 KR-EDGIVVVDQDKCIGCGYCVWACPYGAPQYNPETGKMDKCDMCVD 118
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 1-131 1.45e-48

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 153.56  E-value: 1.45e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   1 MKQCGFYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGGSWvkegeswhHDTFTYYLSIACNHCDEPVCVSGCPT 80
Cdd:COG0437    3 MKRYGMVIDLTKCIGCRACVVACKEENNLPVGVTWRRVRRYEEGEF--------PNVEWLFVPVLCNHCDDPPCVKVCPT 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 813121957  81 GAMHKRkEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:COG0437   75 GATYKR-EDGIVLVDYDKCIGCRYCVAACPYGAPRFNPETGVVEKCTFCAD 124
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
9-117 8.81e-23

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 90.88  E-value: 8.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   9 DSSRCSGCKTCQVSCKDNKDLDVGPKlrrvyeyGGGSW----------------VKEGESWHHDTFT---YYLSIACNHC 69
Cdd:PRK10882  43 DSTLCVGCQACVTKCQEINFPERNPQ-------GEQTWdnpdklspytnniikvWKSGTGVNKDQEEngyAYIKKQCMHC 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 813121957  70 DEPVCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFD 117
Cdd:PRK10882 116 VDPNCVSVCPVSALTKDPKTGIVHYDKDVCTGCRYCMVACPFNVPKYD 163
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 57-131 1.36e-21

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 82.30  E-value: 1.36e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 813121957   57 TFTYYLSIACNHCDEPVCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:pfam13247   1 VDWLFFPEQCRHCLNPPCKASCPVGAIYKDEETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAEKCDMCYD 75
 
Name Accession Description Interval E-value
DMSO_dmsB TIGR02951
DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain ...
 3-131 1.31e-75

DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain B, of an enzyme called the anaerobic dimethyl sulfoxide reductase. Chains A and B are catalytic, while chain C is a membrane anchor.


Pssm-ID: 131996 [Multi-domain]  Cd Length: 161  Bit Score: 221.53  E-value: 1.31e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957    3 QCGFYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGGSWVKEGESWHHDTFTYYLSIACNHCDEPVCVSGCPTGA 82
Cdd:TIGR02951   1 QYGFYVDQTRCSGCKTCQIACKDKNDLEVGVLFRRVYEYEGGGWTEEGEGFHPDVFAYYISISCNHCADPACVKNCPTGA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 813121957   83 MHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:TIGR02951  81 MYKREEDGLVLVDQDKCIGCRYCVWACPYGAPQYDPQQGVMGKCDGCYD 129
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 5-131 1.10e-55

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 170.05  E-value: 1.10e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   5 GFYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGGSWvkegeswhHDTFTYYLSIACNHCDEPVCVSGCPTGAMH 84
Cdd:cd16371    1 GFYFDQERCIGCKACEIACKDKNDLPPGVNWRRVYEYEGGEF--------PEVFAYFLSMSCNHCENPACVKVCPTGAIT 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 813121957  85 KRkEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd16371   73 KR-EDGIVVVDQDKCIGCGYCVWACPYGAPQYNPETGKMDKCDMCVD 118
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 1-131 1.45e-48

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 153.56  E-value: 1.45e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   1 MKQCGFYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGGSWvkegeswhHDTFTYYLSIACNHCDEPVCVSGCPT 80
Cdd:COG0437    3 MKRYGMVIDLTKCIGCRACVVACKEENNLPVGVTWRRVRRYEEGEF--------PNVEWLFVPVLCNHCDDPPCVKVCPT 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 813121957  81 GAMHKRkEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:COG0437   75 GATYKR-EDGIVLVDYDKCIGCRYCVAACPYGAPRFNPETGVVEKCTFCAD 124
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 8-131 2.80e-33

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 114.55  E-value: 2.80e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   8 VDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGGswvkegesWHHDTFTYYLSIACNHCDEPVCVSGCPTGAMHKRk 87
Cdd:cd10551    3 IDLRKCIGCGACVVACKAENNVPPGVFRNRVLEYEVG--------EYPNVKRTFLPVLCNHCENPPCVKVCPTGATYKR- 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 813121957  88 EDGLVVVDDSVCVGCRYCEMRCPYGAPQFD------------TQANVMRKCDGCLD 131
Cdd:cd10551   74 EDGIVLVDYDKCIGCRYCMAACPYGARYFNpeephefgevpvRPKGVVEKCTFCYH 129
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 7-131 9.24e-33

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 112.46  E-value: 9.24e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   7 YVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGgswvkegESWHHDTFTYYLSIACNHCDEPVCVSGCPTGAMHKR 86
Cdd:cd10553    6 YHDSKRCIGCLACEVHCKVKNNLPVGPRLCRIFAVGP-------KMVGGKPRLKFVYMSCFHCENPWCVKACPTGAMQKR 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 813121957  87 KEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd10553   79 EKDGIVYVDQELCIGCKACIEACPWGIPQWNPATGKVVKCDYCMD 123
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 6-131 1.63e-29

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 103.62  E-value: 1.63e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   6 FYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYGGGswvkegeswhhDTFTYYLSIACNHCDEPVCVSGCPTGAMHK 85
Cdd:cd04410    1 LVVDLDRCIGCGTCEVACKQEHGLRPGPDWSRIKVIEGG-----------GLERAFLPVSCMHCEDPPCVKACPTGAIYK 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 813121957  86 RkEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd04410   70 D-EDGIVLIDEDKCIGCGSCVEACPYGAIVFDPEPGKAVKCDLCGD 114
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 5-131 2.75e-29

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 104.99  E-value: 2.75e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   5 GFYVDSSRCSGCKTCQVSCKDNKDLDVGPK-----LRRVYEYGGGSW--VKEGESWHHDTFTYYLSIACNHCDEPVCVSG 77
Cdd:cd10561    1 GVLYDTTRCIGCRACEVACKEWNGLPAEDTafgpgWDNPRDLSAKTYtvIKRYEVETGGKGFVFVKRQCMHCLDPACVSA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 813121957  78 CPTGAMHKRKEdGLVVVDDSVCVGCRYCEMRCPYGAPQF--DTQANVMRKCDGCLD 131
Cdd:cd10561   81 CPVGALRKTPE-GPVTYDEDKCIGCRYCMVACPFNIPKYewDSANPKIRKCTMCYD 135
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 6-131 6.38e-28

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 100.17  E-value: 6.38e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   6 FYVDSSRCSGCKTCQVSCKDNKDL-DVGPKLRRVYEY----GGGSW----VKEGESWHHDTFTYYLSIACNHCDEPVCVS 76
Cdd:cd16366    1 FLVDTSRCTGCRACQVACKQWNGLpAEKTEFTGSYQNppdlTAHTWtlvrFYEVEKPGGDLSWLFRKDQCMHCTDAGCLA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 813121957  77 GCPTGAMHKRkEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd16366   81 ACPTGAIIRT-ETGTVVVDPETCIGCGYCVNACPFDIPRFDEETGRVAKCTLCYD 134
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 7-131 4.60e-27

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 98.14  E-value: 4.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   7 YVDSSRCSGCKTCQVSCKDNKDL---------------DVGPKLRRVYEYgggswvKEGESWHHDTFTYYLSIACNHCDE 71
Cdd:cd10562    2 LVDTSKCTACRGCQVACKQWNQLpaektpftgsyqnppDLTPNTWTLIRF------YEHEEDNGGIRWLFRKRQCMHCTD 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957  72 PVCVSGCPTGAMHKrKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd10562   76 AACVKVCPTGALYK-TENGAVVVDEDKCIGCGYCVAACPFDVPRYDETTNKITKCTLCFD 134
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 7-131 3.23e-26

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 95.40  E-value: 3.23e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   7 YVDSSRCSGCKTCQVSCK----DNKDL------DVGPKLRRVYEYGGGswvkegeswhhdtftYYLSIACNHCDEPVCVS 76
Cdd:cd10563    3 FIDEEKCLGCKLCEVACAvahsKSKDLikakleKERPRPRIRVEESGG---------------RSFPLQCRHCDEPPCVK 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 813121957  77 GCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd10563   68 ACMSGAMHKDPETGIVIHDEEKCVGCWMCVMVCPYGAIRPDKERKVALKCDLCPD 122
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 7-131 7.34e-24

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 89.26  E-value: 7.34e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   7 YVDSSRCSGCKTCQVSCkdnkDLDVGPKLR-RVYEYGGGswvkegeswhhdtftYYLSIACNHCDEPVCVSGCPTGAMHk 85
Cdd:cd16374    2 YVDPERCIGCRACEIAC----AREHSGKPRiSVEVVEDL---------------ASVPVRCRHCEDAPCMEVCPTGAIY- 61

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 813121957  86 RKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd16374   62 RDEDGAVLVDPDKCIGCGMCAMACPFGVPRFDPSLKVAVKCDLCID 107
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 7-129 1.15e-23

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 88.40  E-value: 1.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   7 YVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYgggSWVKEGeswhhdtftYYLSIACNHCDEPVCVSGCPTGAMHKR 86
Cdd:cd10550    2 VVDPEKCTGCRTCELACSLKHEGVFNPSLSRIRVV---RFEPEG---------LDVPVVCRQCEDAPCVEACPVGAISRD 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 813121957  87 KEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:cd10550   70 EETGAVVVDEDKCIGCGMCVEACPFGAIRVDPETGKAIKCDLC 112
EBDH_beta cd10555
beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene ...
 1-129 2.88e-23

beta subunit of ethylbenzene-dehydrogenase (EBDH); This subfamily includes ethylbenzene dehydrogenase (EBDH, EC 1.17.99.2), a member of the DMSO reductase family. EBDH oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. It is a heterotrimer, with the alpha subunit containing the catalytic center with a molybdenum held by two molybdopterin-guanine dinucleotides, the beta subunit containing four iron-sulfur clusters (the electron transfer subunit) and the gamma subunit containing a methionine and a lysine as axial heme ligands. During catalysis, electrons produced by substrate oxidation are transferred to a heme in the gamma subunit and then presumably to a separate cytochrome involved in nitrate respiration.


Pssm-ID: 319877 [Multi-domain]  Cd Length: 316  Bit Score: 91.98  E-value: 2.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   1 MKQCGFYVDSSRCSGCKTCQVSCK--------------DNKDLDVGPKLRRVYEYGGGSWVKEGE--------------- 51
Cdd:cd10555    2 KRQLAMVMDLNKCIGCQTCTVACKtlwtnrngreymywNNVETQPGKGYPKNWEKKGGGFKDKGElkpgiiptledygvp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957  52 ---SWHHDTFT----------------------------------YYLSIACNHCDEPVCVSGCPTGAMHKRKEDGLVVV 94
Cdd:cd10555   82 weyNHEEELFEgkggrvrpspkgdptwgpnwdedqgageypnsyyFYLPRICNHCTNPACLAACPRKAIYKREEDGIVLV 161

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 813121957  95 DDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:cd10555  162 DQDRCRGYRYCVEACPYKKIYFNPVEQKSEKCIFC 196
NarH_like cd16365
beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several ...
 2-129 3.26e-23

beta FeS subunits DMSOR NarH-like family; This subfamily contains beta FeS subunits of several DMSO reductase superfamily, including nitrate reductase A, ethylbenzene dehydrogenase and selenate reductase. DMSO Reductase (DMSOR) family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. . The beta subunits of DMSOR contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system. Nitrate reductase A contains three subunits (the catalytic subunit NarG, the catalytic subunit NarH with four [Fe-S] clusters, and integral membrane subunit NarI) and often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Ethylbenzene dehydrogenase oxidizes the hydrocarbon ethylbenzene to (S)-1-phenylethanol. Selenate reductase catalyzes reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor.


Pssm-ID: 319887 [Multi-domain]  Cd Length: 201  Bit Score: 89.56  E-value: 3.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   2 KQCGFYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRR-----VYEYGG--GSW-VKEGESWHHDTFTYYLSIACNHCDEPV 73
Cdd:cd16365    1 KQFAAVFNLNKCIGCQTCTVACKNAWTYRKGQEYMWwnnveTKPGGGypQDWeVKTIDNGGNTRFFFYLQRLCNHCTNPA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 813121957  74 CVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:cd16365   81 CLAACPRGAIYKREEDGIVLIDQKRCRGYRKCVEQCPYKKIYFNGLSRVSEKCIAC 136
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
9-117 8.81e-23

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 90.88  E-value: 8.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   9 DSSRCSGCKTCQVSCKDNKDLDVGPKlrrvyeyGGGSW----------------VKEGESWHHDTFT---YYLSIACNHC 69
Cdd:PRK10882  43 DSTLCVGCQACVTKCQEINFPERNPQ-------GEQTWdnpdklspytnniikvWKSGTGVNKDQEEngyAYIKKQCMHC 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 813121957  70 DEPVCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFD 117
Cdd:PRK10882 116 VDPNCVSVCPVSALTKDPKTGIVHYDKDVCTGCRYCMVACPFNVPKYD 163
Fer4_11 pfam13247
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 57-131 1.36e-21

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 404184 [Multi-domain]  Cd Length: 99  Bit Score: 82.30  E-value: 1.36e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 813121957   57 TFTYYLSIACNHCDEPVCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:pfam13247   1 VDWLFFPEQCRHCLNPPCKASCPVGAIYKDEETGAVLLDEKTCRGWRECVSACPYNIPRYNDETGKAEKCDMCYD 75
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 5-131 2.61e-21

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 85.13  E-value: 2.61e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   5 GFYVDSSRCSGCKTCQVSCKDNKDLDVGPklrrvYEYGGGSWVKEG----ESWHHDTFT-----------------YYLS 63
Cdd:cd10560    1 GFFTDTSICIGCKACEVACKQWNQLPADG-----YDFSGMSYDNTGdlsaSTWRHVKFIerptedgpaneggdlqwLFMS 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 813121957  64 IACNHCDEPVCVSGCPTGAMHkRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd10560   76 DVCKHCTDAGCLEACPTGAIF-RTEFGTVYIQPDICNGCGYCVAACPFGVIDRNEETGRAHKCTLCYD 142
SER_beta cd10556
Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate ...
 55-129 1.26e-20

Beta subunit of selenate reductase; This subfamily includes beta FeS subunit of selenate reductase (SER), a member of the DMSO reductase family. SER catalyzes the reduction of selenate to selenite in bacterial species that can obtain energy by respiring anaerobically with selenate as the terminal electron acceptor. The enzyme comprises three subunits SerABC, forming a heterotrimer, with the catalytic component (alpha-subunit), iron-sulfur protein (beta-subunit) and monomeric b-type heme-containing gamma subunit. Beta subunit contains coordinating one [3Fe-4S] cluster and three [4Fe-4S] clusters and functions as electron carrier.


Pssm-ID: 319878 [Multi-domain]  Cd Length: 287  Bit Score: 84.43  E-value: 1.26e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 813121957  55 HDTFTYYLSIACNHCDEPVCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:cd10556  130 HPIWFFYLPRICNHCTYPACLAACPRKAIYKREEDGIVLIDQERCRGYRECVEACPYKKPMYNPTTRVSEKCIGC 204
PRK14993 PRK14993
tetrathionate reductase subunit TtrB;
2-129 8.89e-20

tetrathionate reductase subunit TtrB;


Pssm-ID: 184955 [Multi-domain]  Cd Length: 244  Bit Score: 81.46  E-value: 8.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   2 KQCGFYVDSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEYgggswvKEGESWHHDTFTYYLSIACNHCDEPVCVSGCPTG 81
Cdd:PRK14993  42 HRYAMLIDLRRCIGCQSCTVSCTIENQTPQGAFRTTVNQY------QVQREGSQEVTNVLLPRLCNHCDNPPCVPVCPVQ 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 813121957  82 AMHKRKeDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:PRK14993 116 ATFQRE-DGIVVVDNKRCVGCAYCVQACPYDARFINHETQTADKCTFC 162
NarH_beta-like cd10557
beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes ...
 55-129 1.40e-19

beta subunit of nitrate reductase A (NarH) and similar proteins; This subfamily includes nitrate reductase A, a member of the DMSO reductase family. The respiratory nitrate reductase complex (NarGHI) from E. coli is a heterotrimer, with the catalytic subunit (NarG) with a molybdo-bis (molybdopterin guanine dinucleotide) cofactor and an [Fe-S] cluster, the electron transfer subunit (NarH) with four [Fe-S] clusters, and the integral membrane subunit (NarI) with two b-type hemes. Nitrate reductase A often forms a respiratory chain with the formate dehydrogenase via the lipid soluble quinol pool. Electron transfer from formate to nitrate is coupled to proton translocation across the cytoplasmic membrane generating proton motive force by a redox loop mechanism. Demethylmenaquinol (DMKH2) has been shown to be a good substrate for NarGHI in nitrate respiration in E. coli.


Pssm-ID: 319879 [Multi-domain]  Cd Length: 363  Bit Score: 82.41  E-value: 1.40e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 813121957  55 HDTFTYYLSIACNHCDEPVCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:cd10557  168 ENTFMFYLPRICNHCLNPACVAACPSGAIYKREEDGIVLIDQDRCRGWRMCVSACPYKKVYYNWKTGKSEKCIFC 242
TH_beta_N cd10552
N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This ...
 6-129 1.42e-19

N-terminal FeS domain of pyrogallol-phloroglucinol transhydroxylase (TH), beta subunit; This family includes the beta subunit of pyrogallol-phloroglucinol transhydroxylase (TH), a cytoplasmic molybdenum (Mo) enzyme from anaerobic microorganisms like Pelobacter acidigallici and Desulfitobacterium hafniense which catalyzes the conversion of pyrogallol to phloroglucinol, an important building block of plant polymers. TH belongs to the DMSO reductase (DMSOR) family; it is a heterodimer consisting of a large alpha catalytic subunit and a small beta FeS subunit. The beta subunit has two domains with the N-terminal domain containing three [4Fe-4S] centers and a seven-stranded, mainly antiparallel beta-barrel domain. In the anaerobic bacterium Pelobacter acidigallici, gallic acid, pyrogallol, phloroglucinol, or phloroglucinol carboxylic acid are fermented to three molecules of acetate (plus CO2), and TH is the key enzyme in the fermentation pathway, which converts pyrogallol to phloroglucinol in the absence of O2.


Pssm-ID: 319874 [Multi-domain]  Cd Length: 186  Bit Score: 79.68  E-value: 1.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   6 FYVDSSRCSGCKTCQVSCKDnkdldvgpklrrvyEYGGGSW-------VKEGESW------HHDTF----TYYLSIACNH 68
Cdd:cd10552    1 LVIDVAKCNGCYNCFLACKD--------------EHVGNDWpgyaapqPRHGHFWmrilrrERGQYpkvdVAYLPVPCNH 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 813121957  69 CDEPVCVSGCPTGAMHKRkEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:cd10552   67 CDNAPCIKAAKDGAVYKR-DDGIVIIDPEKAKGQKQLVDACPYGAIYWNEELQVPQKCTFC 126
DMSOR_beta_like cd16369
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 6-131 8.04e-19

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319891 [Multi-domain]  Cd Length: 172  Bit Score: 77.43  E-value: 8.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   6 FYVDSSRCSGCKTCQVSCKDNKDLDvgpKLRRVYEYgggsWVKEGESwhhdtfTYYLSIACNHCDEPVCVSGCPTGAMhK 85
Cdd:cd16369    4 FFIDPSRCIGCRACVAACRECGTHR---GKSMIHVD----YIDRGES------TQTAPTVCMHCEDPTCAEVCPADAI-K 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 813121957  86 RKEDGLVV-VDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd16369   70 VTEDGVVQsALKPRCIGCSNCVNACPFGVPKYDEERNLMMKCDMCYD 116
NarY COG1140
Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and ...
 56-129 1.06e-17

Nitrate reductase beta subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440755 [Multi-domain]  Cd Length: 485  Bit Score: 77.54  E-value: 1.06e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 813121957  56 DTFTYYLSIACNHCDEPVCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:COG1140  172 NTFMFYLPRICEHCLNPACVASCPSGAIYKREEDGIVLVDQDKCRGWRMCVSGCPYKKVYFNWKTGKAEKCIFC 245
PRK09898 PRK09898
ferredoxin-like protein;
11-129 7.21e-17

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 72.95  E-value: 7.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957  11 SRCSGCKTCQVSCKDNKDLDVGP-----KLRRVYEYGGGSWVKEGESWHHDTFTyylSIACNHCDEPVCVSGCPTGAMHK 85
Cdd:PRK09898  66 ARCTGCHRCEISCTNFNDGSVGTffsriKIHRNYFFGDNGVGSGGGLYGDLNYT---ADTCRQCKEPQCMNVCPIGAITW 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 813121957  86 RKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:PRK09898 143 QQKEGCITVDHKRCIGCSACTTACPWMMATVNTESKKSSKCVLC 186
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
7-131 2.15e-16

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 70.07  E-value: 2.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   7 YVDSSRCSGCKTCQVSCKDNKDLDVGPKLR---RVYEYGGGSwvkegeswhhdtftyyLSIACNHCDEPVCVSGCPTGAM 83
Cdd:COG1142    6 IADPEKCIGCRTCEAACAVAHEGEEGEPFLpriRVVRKAGVS----------------APVQCRHCEDAPCAEVCPVGAI 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 813121957  84 HKrkEDGLVVVDDSVCVGCRYCEMRCPYGA--PQFDTQANVMRKCDGCLD 131
Cdd:COG1142   70 TR--DDGAVVVDEEKCIGCGLCVLACPFGAitMVGEKSRAVAVKCDLCGG 117
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 8-131 4.71e-16

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 70.88  E-value: 4.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   8 VDSSRCSGCKTCQVSCKDNKDL-DVGPKLRRVYE----YGGGSW--VKEGESWHHDTFTYYLSI-ACNHCDEPVCVSGCP 79
Cdd:cd10558    4 IDVSKCIGCKACQVACKEWNDLrAEVGHNVGTYQnpadLSPETWtlMKFREVEDNGKLEWLIRKdGCMHCADPGCLKACP 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 813121957  80 TGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd10558   84 SPGAIVQYANGIVDFQSDKCIGCGYCIKGCPFDIPRISKDDNKMYKCTLCSD 135
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 7-129 1.36e-14

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 65.74  E-value: 1.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   7 YVDSSRCSGCKTCQVSC-----------KDNKDLDVGPKLRRVYEYGGgswvkegeswhhdtftyYLSIACNHCDEPVCV 75
Cdd:cd10554    3 IADPDKCIGCRTCEVACaaahsgkgifeAGTDGLPFLPRLRVVKTGEV-----------------TAPVQCRQCEDAPCA 65

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 813121957  76 SGCPTGAMhkRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQF-----------DTQANVMRKCDGC 129
Cdd:cd10554   66 NVCPVGAI--SQEDGVVQVDEERCIGCKLCVLACPFGAIEMapttvpgvdweRGPRAVAVKCDLC 128
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 9-129 3.54e-14

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 67.74  E-value: 3.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   9 DSSRCSGCKTCQVSCKDNKDLDVGPKLR-----RVYEYGGGSWVKegeswhhdtftyylSIACNHCDEPVCVSGCPTGAM 83
Cdd:PRK12809   8 EAAECIGCHACEIACAVAHNQENWPLSHsdfrpRIHVVGKGQAAN--------------PVACHHCNNAPCVTACPVNAL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 813121957  84 HKRKEDglVVVDDSVCVGCRYCEMRCPYGApqFDTQANVMRKCDGC 129
Cdd:PRK12809  74 TFQSDS--VQLDEQKCIGCKRCAIACPFGV--VEMVDTIAQKCDLC 115
cyt_nit_nrfC TIGR03149
cytochrome c nitrite reductase, Fe-S protein; Members of this protein family are the Fe-S ...
 9-131 7.81e-13

cytochrome c nitrite reductase, Fe-S protein; Members of this protein family are the Fe-S protein, NrfC, of a cytochrome c nitrite reductase system for which the pentaheme cytochrome c protein, NrfB (family TIGR03146) is an unambiguous marker. Members of this protein family show similarity to other ferredoxin-like proteins, including a subunit of a polysulfide reductase. [Energy metabolism, Electron transport]


Pssm-ID: 274451 [Multi-domain]  Cd Length: 225  Bit Score: 62.49  E-value: 7.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957    9 DSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEygggswvKEGESWHHDTFTYYLSIACNHCDEPVCVSGCPTGAMHKRKE 88
Cdd:TIGR03149  44 DETACIGCTACMDACREVNKVPEGVSRLEIIR-------SEPYGEFPDVEYRFFRKSCQHCDNAPCVAVCPTGASFKDEE 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 813121957   89 DGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGCLD 131
Cdd:TIGR03149 117 TGIVDVHKDLCVGCQYCIAACPYRVRFIHPVTKSADKCNFCRD 159
DMSOR_beta_like cd16368
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 66-131 2.72e-12

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319890 [Multi-domain]  Cd Length: 200  Bit Score: 60.90  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957  66 CNHCDEPVCVSGCPTGAMHKRKEdGLVVVDDSVCVGCRYCEMRCPYGAPQfdTQANV---------------MRKCDGCL 130
Cdd:cd16368   91 CMHCDNPPCAKLCPFGAARKTPE-GAVYIDDDLCFGGAKCRDVCPWHIPQ--RQAGVgiylhlapeyagggvMYKCDLCK 167


                 .
gi 813121957 131 D 131
Cdd:cd16368  168 D 168
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 9-131 6.30e-11

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 58.22  E-value: 6.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   9 DSSRCSGCKTCQVSCKDNKDLDVGPKLRRVYEygggSWVKEGESWHHDTftyylSIACNHCDEPVCVSGCPTGAMhKRKE 88
Cdd:PRK12769   8 NSQQCLGCHACEIACVMAHNDEQHVLSQHHFH----PRITVIKHQQQRS-----AVTCHHCEDAPCARSCPNGAI-SHVD 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 813121957  89 DGLVVVDDSvCVGCRYCEMRCPYGAPQFDTQA-------NVMRKCDGCLD 131
Cdd:PRK12769  78 DSIQVNQQK-CIGCKSCVVACPFGTMQIVLTPvaagkvkATAHKCDLCAG 126
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 65-131 8.00e-11

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 55.78  E-value: 8.00e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 813121957  65 ACNHCDEPVCVSGCPTGAMHkRKEDGLVVVDDSvCVGCRYCEMRCPYGAPQFDtqanVMRKCDGCLD 131
Cdd:cd16367   56 ACRHCVDPVCMIGCPTGAIH-RDDGGEVVISDA-CCGCGNCASACPYGAIQMV----RAVKCDLCAG 116
W-FDH cd10559
tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit ...
 5-131 9.38e-11

tungsten-containing formate dehydrogenase, small subunit; This subfamily contains beta subunit of Tungsten-containing formate dehydrogenase (W-FDH), a member of the DMSO reductase family. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319881 [Multi-domain]  Cd Length: 200  Bit Score: 56.67  E-value: 9.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   5 GFYVDSSRCSGCKTCQVSCKDNKDLDVGP-KLRRVYE----YGGGSW--VKEGESWHHDTFTYYLSIA--CNHCDEPVCV 75
Cdd:cd10559    1 SFLIDTTRCTACRGCQVACKQWNQLPAEQtKNTGSHQnppdLSANTYklVRFNEVRNENGKPDWLFFPdqCRHCVTPPCK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957  76 SGCP--TGAMHKRKEDGLVVVDDSVCVGCrYCEMR--CPYGAPQFDTQANVMRKCDGCLD 131
Cdd:cd10559   81 DAADmvPGAVIQDEATGAVVFTEKTAELD-FDDVLsaCPYNIPRKNEATGRIVKCDMCID 139
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 64-129 1.26e-08

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 49.58  E-value: 1.26e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 813121957  64 IACNHCDEPVCVSGCPTGAMHKRKeDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:cd16370   51 VVCRACEDPPCAEACPTGALEPRK-GGGVVLDKEKCIGCGNCVKACIVGAIFWDEETNKPIICIHC 115
PRK10330 PRK10330
electron transport protein HydN;
8-113 2.15e-08

electron transport protein HydN;


Pssm-ID: 182382 [Multi-domain]  Cd Length: 181  Bit Score: 49.89  E-value: 2.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   8 VDSSRCSGCKTCQVSC-------KDNKDLDVGPKLRRVYEYGGgswvkegeswhhdtFTYYLSIACNHCDEPVCVSGCPT 80
Cdd:PRK10330   7 ADASKCIGCRTCEVACvvshqenQDCASLTPETFLPRIHVIKG--------------VNVSTATVCRQCEDAPCANVCPN 72

                         90       100       110
                 ....*....|....*....|....*....|...
gi 813121957  81 GAMhkRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:PRK10330  73 GAI--SRDKGFVHVMQERCIGCKTCVVACPYGA 103
NapF COG1145
Ferredoxin [Energy production and conversion];
66-113 4.20e-06

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 44.33  E-value: 4.20e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 813121957  66 CNHCDepVCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:COG1145  184 CIGCG--LCVKVCPTGAIRLKDGKPQIVVDPDKCIGCGACVKVCPVGA 229
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 65-113 1.21e-05

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 40.42  E-value: 1.21e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 813121957  65 ACNHCdePVCVSGCPTGAMhkRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:COG2221   16 KCIGC--GLCVAVCPTGAI--SLDDGKLVIDEEKCIGCGACIRVCPTGA 60
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
66-126 1.36e-05

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 40.48  E-value: 1.36e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 813121957  66 CNHCDepVCVSGCPTGAMHKrkEDGLVVVDDSVCVGCRYCEMRCPYGA--PQFDTQANVMRKC 126
Cdd:COG2768   13 CIGCG--ACVKVCPVGAISI--EDGKAVIDPEKCIGCGACIEVCPVGAikIEWEEDEEFQEKM 71
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 66-113 2.22e-05

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 42.55  E-value: 2.22e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 813121957  66 CNHCDEpvCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:PRK12771 512 CFECDN--CYGACPQDAIIKLGPGRRYHFDYDKCTGCHICADVCPCGA 557
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
93-129 3.84e-05

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 41.77  E-value: 3.84e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 813121957  93 VVDDSVCVGCRYCEMRCPYGAPQFDTQANVM---RKCDGC 129
Cdd:COG1148  492 EVDPEKCTGCGRCVEVCPYGAISIDEKGVAEvnpALCKGC 531
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 66-110 4.68e-05

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 39.70  E-value: 4.68e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 813121957  66 CNHCDepVCVSGCPTGAMHKRKEDGLV------VVDDSVCVGCRYCEMRCP 110
Cdd:PRK09626  18 CKACD--ICVSVCPAGVLAMRIDPHAVlgkmikVVHPESCIGCRECELHCP 66
PRK13795 PRK13795
hypothetical protein; Provisional
 66-110 5.22e-05

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 41.52  E-value: 5.22e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 813121957  66 CNHCDepVCVSGCPTGAMHKRKEDGLVVVDDSVCVGCRYCEMRCP 110
Cdd:PRK13795 583 CVGCG--VCVGACPTGAIRIEEGKRKISVDEEKCIHCGKCTEVCP 625
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 66-113 5.56e-05

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 38.56  E-value: 5.56e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 813121957  66 CNHCDepVCVSGCPTGAMhKRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:COG1149   13 CIGCG--LCVEVCPEGAI-KLDDGGAPVVDPDLCTGCGACVGVCPTGA 57
Rli1 COG1245
Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...
 66-113 7.32e-05

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440858 [Multi-domain]  Cd Length: 592  Bit Score: 40.92  E-value: 7.32e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 813121957  66 CNHcdepVCVSGCP---TG--AMHKRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:COG1245   17 CNY----ECIKYCPvnrTGkeAIEIDEDDGKPVISEELCIGCGICVKKCPFDA 65
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 73-110 1.33e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 39.16  E-value: 1.33e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 813121957  73 VCVSGCPTG--AMHKRKEDGLVVVDDSVCVGCRYCEMRCP 110
Cdd:cd16373  104 VCVEACPTEaiAIVLEDDVLRPVVDEDKCVGCGLCEYVCP 143
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
65-113 1.37e-04

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 40.01  E-value: 1.37e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 813121957  65 ACNHCDEpvCVSGCPTGAMhkRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:COG4624   92 KCKNCYP--CVRACPVKAI--KVDDGKAEIDEEKCISCGQCVAVCPFGA 136
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 64-129 2.44e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 38.39  E-value: 2.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957  64 IACNHCDEpVCVSGCPTGAMHKRKED------GLVVVDDSVCV------GCRYCEMRCPYGAPQFDTQANVMR------K 125
Cdd:cd16373   53 GPCDLCCD-ACVEVCPTGALRPLDLEeqkvkmGVAVIDKDRCLawqggtDCGVCVEACPTEAIAIVLEDDVLRpvvdedK 131


                 ....
gi 813121957 126 CDGC 129
Cdd:cd16373  132 CVGC 135
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 66-129 2.66e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 38.09  E-value: 2.66e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 813121957  66 CNHCDEpvCVSGCPTGAMhKRKEDGLVVVDDSVCVGCRYCEMRCPYGAPQFDTQANVMRKCDGC 129
Cdd:cd16372   49 CNQCGE--CIDVCPTGAI-TRDANGVVMINKKLCVGCLMCVGFCPEGAMFKHEDYPEPFKCIAC 109
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 66-113 3.18e-04

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 38.71  E-value: 3.18e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 813121957  66 CNHCDEpvCVSGCPTGAMhKRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:PRK00783 171 CDECEK--CVEACPRGVL-ELKEGKLVVTDLLNCSLCKLCERACPGKA 215
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
74-112 4.54e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 38.38  E-value: 4.54e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 813121957  74 CVSGCPTGAMHKrkEDGLVVVDDSVCVGCRYCEMRCPYG 112
Cdd:PRK07118 147 CVAACPFDAIHI--ENGLPVVDEDKCTGCGACVKACPRN 183
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
71-131 7.02e-04

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 37.73  E-value: 7.02e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 813121957  71 EPVCVSGCPTGAMHK--RKEDGLVV-VDDSVCVGCRYCEMRCPYGAPQFDTQANvMRKCDGCLD 131
Cdd:COG0348  181 RQWCRYLCPYGAFQGllSDLSTLRVrYDRGDCIDCGLCVKVCPMGIDIRKGEIN-QSECINCGR 243
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 66-113 8.86e-04

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 35.46  E-value: 8.86e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 813121957  66 CNHCDepVCVSGCPTGAMHKRKEDG-LVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:COG1146   10 CIGCG--ACVEVCPVDVLELDEEGKkALVINPEECIGCGACELVCPVGA 56
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
8-113 9.16e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 37.61  E-value: 9.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 813121957   8 VDSSRCSGCKTCQVSCKdNKDLDVGPKLRRVYEY----GGGSWVKEgeswhhdtftyYLSIACNHCDepVCVSGCPTGAM 83
Cdd:PRK07118 165 VDEDKCTGCGACVKACP-RNVIELIPKSARVFVAcnskDKGKAVKK-----------VCEVGCIGCG--KCVKACPAGAI 230

                         90       100       110
                 ....*....|....*....|....*....|
gi 813121957  84 hkRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:PRK07118 231 --TMENNLAVIDQEKCTSCGKCVEKCPTKA 258
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 74-113 9.71e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 35.79  E-value: 9.71e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 813121957  74 CVSGCPTGAMHKrkEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:COG4231   30 CVKVCPADAIEE--GDGKAVIDPDLCIGCGSCVQVCPVDA 67
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 73-113 1.59e-03

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 35.84  E-value: 1.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 813121957  73 VCVSGCPTGAMHKRKEDGL-------VVVDDSVCVGCRYCEMRCPYGA 113
Cdd:cd10549   47 ACVEVCPTGAIELTPEGKEyvpkekeAEIDEEKCIGCGLCVKVCPVDA 94
PRK13409 PRK13409
ribosome biogenesis/translation initiation ATPase RLI;
66-113 1.61e-03

ribosome biogenesis/translation initiation ATPase RLI;


Pssm-ID: 184037 [Multi-domain]  Cd Length: 590  Bit Score: 37.10  E-value: 1.61e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 813121957  66 CNHcdepVCVSGCPTGAMHKR-----KEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:PRK13409  17 CNY----ECIKYCPVVRTGEEtieidEDDGKPVISEELCIGCGICVKKCPFDA 65
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 66-113 2.05e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 34.72  E-value: 2.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 813121957  66 CNHCDepVCVSGCPTGA--MHKRKEDGLVVVDDSVCVGCRYCEMRCPYGA 113
Cdd:COG1143    4 CIGCG--LCVRVCPVDAitIEDGEPGKVYVIDPDKCIGCGLCVEVCPTGA 51
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 74-110 3.72e-03

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 35.74  E-value: 3.72e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 813121957  74 CVSGCPTGAMHKrKEDGLVVVDDSVCVGCRYCEMRCP 110
Cdd:COG2878  145 CIKACPFDAIVG-AAKGMHTVDEDKCTGCGLCVEACP 180
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
8-84 8.23e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 34.84  E-value: 8.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 813121957   8 VDSSRCSGCKTCQVSCkdnkdldvgpklrrvyEYGGGSWVKEGESWHHDTftyylsiACNHCDepVCVSGCPTGAMH 84
Cdd:COG1148  493 VDPEKCTGCGRCVEVC----------------PYGAISIDEKGVAEVNPA-------LCKGCG--TCAAACPSGAIS 544
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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