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Conserved domains on  [gi|800309297|emb|CFD26666|]
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Putative CRISPR-associated metal-dependent deoxyribonuclease Cas1 [Mycobacterium tuberculosis]

Protein Classification

CRISPR-associated endonuclease Cas1( domain architecture ID 10794500)

CRISPR associated endonuclease Cas1 is one of the most conserved DNA endonucleases in CRISPR-Cas systems. Cas1 mediates the adaptation process in cooperation with another ssRNA-specific endonuclease Cas2. In addition to anti-viral immunity, Cas1 is also involved in many processes including chromosome segregation and recombinational repair of DNA double-strand breaks.

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
cas1 TIGR00287
CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the ...
3-325 7.94e-116

CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the most universal CRISPR system protein. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is a metal-dependent DNA-specific endonuclease.


:

Pssm-ID: 272998  Cd Length: 323  Bit Score: 338.16  E-value: 7.94e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297    3 QLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTP-DV 81
Cdd:TIGR00287   1 TLYVLEYGSYLSRKGNTLVVEKEGKKKWNIPVANVDCIVLFGGVSISSAAIRLLAKRGIDIVFFGGDGNYVGRLSPQeSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   82 SYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRT----MKHSLAWVDrsgSLAELNGFEGN 157
Cdd:TIGR00287  81 STVELRLAQVKAYLDEEKRLKLAKEFVSGKIANQAALLKYLTRRREDLRSYLEeyesLMKELASAD---SIEELMGIEGN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  158 AAKAYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVW 237
Cdd:TIGR00287 158 AARAYYAALAQLLPDEFGFNGRSKRPPKDPFNALLSYGYSLLYSNVLTAIYIAGLDPYIGFLHTDRSGRPSLVLDLMEEF 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  238 RAPIIDDTVLRLIADGVVDTRAFSKNSdtGAVFATREATRSIARAFGNRIARTATYIKGDPhRYTFQYALDLQLQSLVRV 317
Cdd:TIGR00287 238 KPQIVDRLVFSLINRNIITEEDFEKIS--NGVYLGEEGRKKFLQAFEERLQTTVTHPGLNR-RVSYLDIIILQARKLAKA 314

                  ....*...
gi 800309297  318 IEAGHPAR 325
Cdd:TIGR00287 315 LRGEERYR 322
 
Name Accession Description Interval E-value
cas1 TIGR00287
CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the ...
3-325 7.94e-116

CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the most universal CRISPR system protein. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is a metal-dependent DNA-specific endonuclease.


Pssm-ID: 272998  Cd Length: 323  Bit Score: 338.16  E-value: 7.94e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297    3 QLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTP-DV 81
Cdd:TIGR00287   1 TLYVLEYGSYLSRKGNTLVVEKEGKKKWNIPVANVDCIVLFGGVSISSAAIRLLAKRGIDIVFFGGDGNYVGRLSPQeSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   82 SYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRT----MKHSLAWVDrsgSLAELNGFEGN 157
Cdd:TIGR00287  81 STVELRLAQVKAYLDEEKRLKLAKEFVSGKIANQAALLKYLTRRREDLRSYLEeyesLMKELASAD---SIEELMGIEGN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  158 AAKAYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVW 237
Cdd:TIGR00287 158 AARAYYAALAQLLPDEFGFNGRSKRPPKDPFNALLSYGYSLLYSNVLTAIYIAGLDPYIGFLHTDRSGRPSLVLDLMEEF 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  238 RAPIIDDTVLRLIADGVVDTRAFSKNSdtGAVFATREATRSIARAFGNRIARTATYIKGDPhRYTFQYALDLQLQSLVRV 317
Cdd:TIGR00287 238 KPQIVDRLVFSLINRNIITEEDFEKIS--NGVYLGEEGRKKFLQAFEERLQTTVTHPGLNR-RVSYLDIIILQARKLAKA 314

                  ....*...
gi 800309297  318 IEAGHPAR 325
Cdd:TIGR00287 315 LRGEERYR 322
Cas1_I-II-III cd09636
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
4-260 6.10e-99

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187767  Cd Length: 260  Bit Score: 292.66  E-value: 6.10e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   4 LYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTP-DVS 82
Cdd:cd09636    1 LYVLEYGSYLSRKGNTLVVEKEGELKKNIPVANVDCIVIFGGVSISSAAIRELAKRGIDIVFLGGDGNYLGRLYPPePGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  83 YAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRTMK--HSLAWVDRSGSLAELNGFEGNAAK 160
Cdd:cd09636   81 SVFTRRAQYKAYLNPAKRLKLAREFVEGKLANQAALLRYLTRRREDLKSELAEYiaELLKELDNANSIEELMGIEGNAAR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297 161 AYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAP 240
Cdd:cd09636  161 AYYAALAQLLPDEFGFNGRSRRPPKDPFNALLSYGYSLLYSNVLTAIYIAGLDPYIGFLHTDRSGRPSLVLDLMEEFRPQ 240
                        250       260
                 ....*....|....*....|
gi 800309297 241 IIDDTVLRLIADGVVDTRAF 260
Cdd:cd09636  241 IVDRLVFSLINRGIITPEDF 260
Cas_Cas1 pfam01867
CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats ...
4-283 1.78e-91

CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.


Pssm-ID: 460366  Cd Length: 283  Bit Score: 274.33  E-value: 1.78e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297    4 LYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPDVSY 83
Cdd:pfam01867   1 LYVTTPGAYLSRKGETLVVEKEGEEKKRIPLEDVEQIVIFGNVSISTAALRLLAERGIPVHFLSYYGRYLGRLYPEVSGN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   84 APRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIR---AHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAK 160
Cdd:pfam01867  81 VLLRRAQYRAYDDEEKRLELARSFVAGKLRNQRTVLRrynRDRKDEALEEAIEELEELLKKLERADSIDELRGIEGNAAR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  161 AYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAP 240
Cdd:pfam01867 161 AYFSAFDELLPKEFGFEGRSRRPPLDPVNALLSFGYTLLYSDVLSALEAVGLDPYIGFLHEDRPGRPSLALDLMEEFRPV 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 800309297  241 IIDDTVLRLIADGVVDTRAFSKNSdtGAVFATREATRSIARAF 283
Cdd:pfam01867 241 IVDRLVLSLINRGQITPKDFEKRE--NGVLLNDEGRKKFLKAY 281
Cas1 COG1518
CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated ...
4-319 4.69e-91

CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated integrase Cas1 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 441127  Cd Length: 329  Bit Score: 275.16  E-value: 4.69e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   4 LYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPD-VS 82
Cdd:COG1518    2 LYITEPGAYLSRKGNTLVVEKEDEEKKRVPLEDIEQIVLFGEVSLSTALLRFLAENGIPVHFLDYYGRYLGRLLPREsGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  83 YAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIR--AHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAK 160
Cdd:COG1518   82 NVLLRRAQYQAYLDEEKRLALARSIVRGKIRNQRAVLRryGRRRKEDLEEAIERLEELLKRLEEADSIDELRGIEGNAAR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297 161 AYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAP 240
Cdd:COG1518  162 IYFSALDGLLPEDFRFEGRSRRPPRDPVNALLSFGYTLLYSDVLSAIYAAGLDPYIGFLHEPRPGRPSLALDLMEEFRPI 241
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 800309297 241 IIDDTVLRLIADGVVDTRAFSKnsDTGAVFATREATRSIARAFGNRIARTATYIKGDpHRYTFQYALDLQLQSLVRVIE 319
Cdd:COG1518  242 LVDRLVLSLINRGQITPKDFEK--ELGGVLLTEEGRKKFLEAFEERLQETIKHPFLG-RKVSYRRLIRLQARKLAKHLR 317
 
Name Accession Description Interval E-value
cas1 TIGR00287
CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the ...
3-325 7.94e-116

CRISPR-associated endonuclease Cas1; This model identifies CRISPR-associated protein Cas1, the most universal CRISPR system protein. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Cas1 is a metal-dependent DNA-specific endonuclease.


Pssm-ID: 272998  Cd Length: 323  Bit Score: 338.16  E-value: 7.94e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297    3 QLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTP-DV 81
Cdd:TIGR00287   1 TLYVLEYGSYLSRKGNTLVVEKEGKKKWNIPVANVDCIVLFGGVSISSAAIRLLAKRGIDIVFFGGDGNYVGRLSPQeSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   82 SYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRT----MKHSLAWVDrsgSLAELNGFEGN 157
Cdd:TIGR00287  81 STVELRLAQVKAYLDEEKRLKLAKEFVSGKIANQAALLKYLTRRREDLRSYLEeyesLMKELASAD---SIEELMGIEGN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  158 AAKAYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVW 237
Cdd:TIGR00287 158 AARAYYAALAQLLPDEFGFNGRSKRPPKDPFNALLSYGYSLLYSNVLTAIYIAGLDPYIGFLHTDRSGRPSLVLDLMEEF 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  238 RAPIIDDTVLRLIADGVVDTRAFSKNSdtGAVFATREATRSIARAFGNRIARTATYIKGDPhRYTFQYALDLQLQSLVRV 317
Cdd:TIGR00287 238 KPQIVDRLVFSLINRNIITEEDFEKIS--NGVYLGEEGRKKFLQAFEERLQTTVTHPGLNR-RVSYLDIIILQARKLAKA 314

                  ....*...
gi 800309297  318 IEAGHPAR 325
Cdd:TIGR00287 315 LRGEERYR 322
Cas1_I-II-III cd09636
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
4-260 6.10e-99

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187767  Cd Length: 260  Bit Score: 292.66  E-value: 6.10e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   4 LYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTP-DVS 82
Cdd:cd09636    1 LYVLEYGSYLSRKGNTLVVEKEGELKKNIPVANVDCIVIFGGVSISSAAIRELAKRGIDIVFLGGDGNYLGRLYPPePGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  83 YAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRTMK--HSLAWVDRSGSLAELNGFEGNAAK 160
Cdd:cd09636   81 SVFTRRAQYKAYLNPAKRLKLAREFVEGKLANQAALLRYLTRRREDLKSELAEYiaELLKELDNANSIEELMGIEGNAAR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297 161 AYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAP 240
Cdd:cd09636  161 AYYAALAQLLPDEFGFNGRSRRPPKDPFNALLSYGYSLLYSNVLTAIYIAGLDPYIGFLHTDRSGRPSLVLDLMEEFRPQ 240
                        250       260
                 ....*....|....*....|
gi 800309297 241 IIDDTVLRLIADGVVDTRAF 260
Cdd:cd09636  241 IVDRLVFSLINRGIITPEDF 260
Cas1_I-II-III cd09634
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
4-319 3.58e-96

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187766  Cd Length: 317  Bit Score: 287.59  E-value: 3.58e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   4 LYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPD-VS 82
Cdd:cd09634    3 LYITTPGAYLSRKGNRLVVEKEDEKKKRIPLEDIDSIVIFGNVSISTAALRLLAENGIPVHFLDYYGRYLGRLYPPEgGR 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  83 YAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALI-RAHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAKA 161
Cdd:cd09634   83 SVLLRRAQYEAYLDPEKRLELAREIVRGKIRNQRRVLkRYARDGKELLLALAELEELLEKLDKAKSIEELRGIEGNAAKI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297 162 YFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPI 241
Cdd:cd09634  163 YFEALFQLLPKEFRFEGRSRRPPKDPVNALLSYGYSLLYSAVLSAIVAAGLDPYIGFLHEDRPGRPSLALDLMEEFRPII 242
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 800309297 242 IDDTVLRLIADGVVDTRAFSKnsDTGAVFATREATRSIARAFGNRIARTATYIKGdpHRYTFQYALDLQLQSLVRVIE 319
Cdd:cd09634  243 VDRLVLSLINKGQIKKKDFEK--ELGGVLLTEEGRKKLIEALEERLKETIKHYLG--RKVSYRRLIRLQAYKLAKHLR 316
Cas_Cas1 pfam01867
CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats ...
4-283 1.78e-91

CRISPR associated protein Cas1; Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein. Cas1 may be involved in linking DNA segments to CRISPR.


Pssm-ID: 460366  Cd Length: 283  Bit Score: 274.33  E-value: 1.78e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297    4 LYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPDVSY 83
Cdd:pfam01867   1 LYVTTPGAYLSRKGETLVVEKEGEEKKRIPLEDVEQIVIFGNVSISTAALRLLAERGIPVHFLSYYGRYLGRLYPEVSGN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   84 APRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIR---AHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAK 160
Cdd:pfam01867  81 VLLRRAQYRAYDDEEKRLELARSFVAGKLRNQRTVLRrynRDRKDEALEEAIEELEELLKKLERADSIDELRGIEGNAAR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  161 AYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAP 240
Cdd:pfam01867 161 AYFSAFDELLPKEFGFEGRSRRPPLDPVNALLSFGYTLLYSDVLSALEAVGLDPYIGFLHEDRPGRPSLALDLMEEFRPV 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 800309297  241 IIDDTVLRLIADGVVDTRAFSKNSdtGAVFATREATRSIARAF 283
Cdd:pfam01867 241 IVDRLVLSLINRGQITPKDFEKRE--NGVLLNDEGRKKFLKAY 281
Cas1 COG1518
CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated ...
4-319 4.69e-91

CRISPR-Cas system-associated integrase Cas1 [Defense mechanisms]; CRISPR-Cas system-associated integrase Cas1 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 441127  Cd Length: 329  Bit Score: 275.16  E-value: 4.69e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   4 LYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPD-VS 82
Cdd:COG1518    2 LYITEPGAYLSRKGNTLVVEKEDEEKKRVPLEDIEQIVLFGEVSLSTALLRFLAENGIPVHFLDYYGRYLGRLLPREsGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  83 YAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIR--AHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAK 160
Cdd:COG1518   82 NVLLRRAQYQAYLDEEKRLALARSIVRGKIRNQRAVLRryGRRRKEDLEEAIERLEELLKRLEEADSIDELRGIEGNAAR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297 161 AYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAP 240
Cdd:COG1518  162 IYFSALDGLLPEDFRFEGRSRRPPRDPVNALLSFGYTLLYSDVLSAIYAAGLDPYIGFLHEPRPGRPSLALDLMEEFRPI 241
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 800309297 241 IIDDTVLRLIADGVVDTRAFSKnsDTGAVFATREATRSIARAFGNRIARTATYIKGDpHRYTFQYALDLQLQSLVRVIE 319
Cdd:COG1518  242 LVDRLVLSLINRGQITPKDFEK--ELGGVLLTEEGRKKFLEAFEERLQETIKHPFLG-RKVSYRRLIRLQARKLAKHLR 317
Cas1_I-C cd09721
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
20-286 1.13e-54

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187852  Cd Length: 338  Bit Score: 182.05  E-value: 1.13e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  20 VIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPdVSYAPRLRQQVHR-TDDPA 98
Cdd:cd09721   21 VVVEVEGEKKARVPLHHLGGIVCFGNVGLSPFLMGRCAEDGISLVFLTENGRFLARVEGP-VSGNVLLRRAQYRaADDPE 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  99 FCLSLSKRIVSRKILNQ-QALIRA---HTSGQDVA---ESIRTMKHSLAWVDRSGSLAELNGFEGNAAKAYFTALGHLVP 171
Cdd:cd09721  100 RSLAIARSIVAGKIRNArQVLLRAardHGEEDDRAaleAAADRLAVALRRLQRADDLDELRGIEGEAARLYFAVFDHLLR 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297 172 QE---FAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPIIDDTVLR 248
Cdd:cd09721  180 QDapaFRFDGRSRRPPLDPVNALLSFLYTLLTHDCRSALEGVGLDPAVGFLHRDRPGRPSLALDLMEEFRAVLADRLALS 259
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 800309297 249 LIADGVVDTRAFSKnSDTGAVFATREATRSIARAFGNR 286
Cdd:cd09721  260 LINRGQLTAKDFEV-REGGAVLLTDDARKTVLVAYQER 296
cas1_DVULG TIGR03640
CRISPR-associated endonuclease Cas1, subtype I-C/DVULG; The CRISPR-associated protein Cas1 is ...
20-286 1.83e-54

CRISPR-associated endonuclease Cas1, subtype I-C/DVULG; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.


Pssm-ID: 188360  Cd Length: 340  Bit Score: 181.28  E-value: 1.83e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   20 VIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPdVSYAPRLRQQVHR-TDDPA 98
Cdd:TIGR03640  22 VVVEVEGEKKARVPLHHLGGIVCFGNVGLSPFLMGRCAEDGISLVFLTENGRFLARVEGP-VSGNVLLRRAQYRaADDPE 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   99 FCLSLSKRIVSRKILNQQALI----RAHTSGQDVA---ESIRTMKHSLAWVDRSGSLAELNGFEGNAAKAYFTALGHLVP 171
Cdd:TIGR03640 101 RSLAIARSIVAGKIRNARQVLlraaRDHGEEDDAAaleAAADRLAVALRRLQRADDLDSLRGIEGEAARLYFAVFDHLLR 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  172 QE---FAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPIIDDTVLR 248
Cdd:TIGR03640 181 QDrpaFRFDGRSRRPPLDPVNALLSFLYTLLTHDCRSALEGVGLDPAVGFLHRDRPGRPSLALDLMEEFRAVLADRLALS 260
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 800309297  249 LIADGVVDTRAFSKnSDTGAVFATREATRSIARAFGNR 286
Cdd:TIGR03640 261 LINRGQLTAKDFEV-REGGAVLLTDDARKTVLVAYQER 297
cas1_CYANO TIGR04093
CRISPR-associated endonuclease Cas1, subtype CYANO; The CRISPR-associated protein Cas1 is ...
4-286 1.83e-53

CRISPR-associated endonuclease Cas1, subtype CYANO; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes a clade of Cas1 limited to the CYANO subtype of CRISPR/Cas system and most often the type found there.


Pssm-ID: 274976  Cd Length: 323  Bit Score: 178.39  E-value: 1.83e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297    4 LYVSDSVSRISFADGRVIVwSEELGESQ---YPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRIsTPD 80
Cdd:TIGR04093   3 LYITQPDAKISKDDGRIIV-VDSDGEEKvasFPLIKVETIVVFGEATLTTPALAHLLERGIVLHYLTRFGKYFGSL-VPE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   81 VSYAPRLRQQVHRT-DDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIrtmkhsLAWVDRSGSLAELNGFEGNAA 159
Cdd:TIGR04093  81 LTRNTILRVAQHQAhISPQQRLAIAREIVRGKLRNSRTMLYRRGRKQTKIPEL------EKPVDDKNSLDSLRGLEGEAA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  160 KAYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRA 239
Cdd:TIGR04093 155 AIYFGCLSDLLPDEWSFHGRTRRPPTDPVNALLSLGYALLRTQVLSALRIVGLDPYIGFLHVDRHGRPALALDLMEEFRP 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 800309297  240 PIIDDTVLRLIADGVVDTRAFskNSDTGAVFATREATRSIARAFGNR 286
Cdd:TIGR04093 235 IIVDAVVLRLINRKMLKPKDF--QEEPGAVRLKDEAFKLFLGKFEEK 279
Cas1_I-B cd09722
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
33-316 4.16e-33

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain


Pssm-ID: 187853  Cd Length: 320  Bit Score: 124.63  E-value: 4.16e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  33 PIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGristpdvSYAPR--------LRQQVHRTDDPAFCLSLS 104
Cdd:cd09722   29 PVENIDEIYVFGEVSLNSKALSFLSKKGIPIHFFNYYGYYSG-------SFYPReslnsgylIVKQVEHYLDSEKRLELA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297 105 KRIVSRKILN-QQALIRAHTSGQDVAESIRTMKHSLAWVDrsgSLAELNGFEGNAAKAYFTALGHLVPQEFAFQGRSTRP 183
Cdd:cd09722  102 RSFVEGAAHNmRRVLKYYKDRGDDLDDYLDEIEEQKESAN---SINELMGVEGNIRKTYYSAFDEILKDEFRFEKRTRRP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297 184 PLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPIIDDTVLRLIADGVVDTRAFSKn 263
Cdd:cd09722  179 PKNELNALISFGNSLLYTTVLSEIYKTHLNPTISYLHEPSERRFSLALDIAEIFKPIIVDRLIFRLVNKKIIKEKHFEK- 257
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 800309297 264 sDTGAVFATREATRSIARAFGNRIARTatyIKgdpHR-----YTFQYALDLQLQSLVR 316
Cdd:cd09722  258 -DLNGVLLNEEGRKKFVKEFEEKLKTT---IK---HRklkrkVSYRRLIRLELYKLIK 308
cas1_HMARI TIGR03641
CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP; The CRISPR-associated protein ...
33-316 1.96e-32

CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.


Pssm-ID: 274695  Cd Length: 320  Bit Score: 123.10  E-value: 1.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   33 PIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGristpdvSYAPR--------LRQQVHRTDDPAFCLSLS 104
Cdd:TIGR03641  30 PVENIDEIYVFGEVSLNSKALSFLSKKGIPIHFFNYYGYYSG-------SFYPReslnsgylIVKQVEHYLDSEKRLELA 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  105 KRIVSRKILNQQALIRAHTSGQDVAESIRTMKHSLAwvdRSGSLAELNGFEGNAAKAYFTALGHLVPQEFAFQGRSTRPP 184
Cdd:TIGR03641 103 RSFVEGAAHNMRRVLKYYKKRGKDLDKIEAYLESLK---EAKSINELMGVEGNIRKTYYSAFDEILPKGFRFEKRTRRPP 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  185 LDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPIIDDTVLRLIADGVVDTRAFSKns 264
Cdd:TIGR03641 180 KNELNALISFGNSLLYTTVLSEIYKTHLNPTISYLHEPSERRFSLALDIAEIFKPIIVDRLIFRLVNKKIIKEKHFEK-- 257
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 800309297  265 DTGAVFATREATRSIARAFGNRIARTatyIKgdpHR-----YTFQYALDLQLQSLVR 316
Cdd:TIGR03641 258 DLNGVLLNEEGRKKFIKEFEEKLKTT---IK---HRklkrkVSYRRLIRLELYKLIK 308
cas1_NMENI TIGR03639
CRISPR-associated endonuclease Cas1, subtype II/NMENI; The CRISPR-associated protein Cas1 is ...
4-250 1.31e-17

CRISPR-associated endonuclease Cas1, subtype II/NMENI; The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.


Pssm-ID: 274694  Cd Length: 278  Bit Score: 81.53  E-value: 1.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297    4 LYVSDSvSRISFADGRVIVWSEElGESQYPIETLDGItLFGRP--TMTTPFIVEMLkrERDIQLFTTDghyqgRISTPDV 81
Cdd:TIGR03639   4 VEISNH-EKLSLKLNQLVIKKDG-EEVTLPLEDIDVI-LIENPqiTISSALLSALA--ENNIALIFCD-----EKHLPVG 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   82 SYAP---------RLRQQVHRTDDpaFCLSLSKRIVSRKILNQQALIrAHTSGQDVAESIRTMKHSLawvdRSGslaELN 152
Cdd:TIGR03639  74 QLLPfyghhrslkRLKLQIDWSLP--LKKQLWQKIIKQKILNQAFVL-EKLNLDEDSEKLENLANKV----ESG---DKT 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  153 GFEGNAAKAYFTALghlvpqeFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASD 232
Cdd:TIGR03639 144 NREAHAAKLYFKTL-------FGKDFSRDDDGEDPINAALNYGYAILRSAVARALVKSGLLPRLGIFHKSEYNPFNLADD 216
                         250
                  ....*....|....*...
gi 800309297  233 LMEVWRaPIIDDTVLRLI 250
Cdd:TIGR03639 217 LMEPFR-PLVDYLVYELL 233
Cas1_II cd09720
CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short ...
4-256 9.09e-17

CRISPR/Cas system-associated protein Cas1; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.


Pssm-ID: 187851  Cd Length: 275  Bit Score: 78.83  E-value: 9.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297   4 LYVSDSvSRISFADGRVIVWSEElGESQYPIETLDGItLFGRP--TMTTPFIVEMLkrERDIQLFTTDGHYQgristPDV 81
Cdd:cd09720    4 VEISNH-EKLSLKLNQLVVKKDN-GRITLPLEDIDVI-LIENPqvTISAALLNALA--ENNIALIFCDEKHL-----PVG 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297  82 SYAP---------RLRQQVHRTDDpaFCLSLSKRIVSRKILNQQALIrAHTSGQDVAESIRTMKHSLawvdRSGslaELN 152
Cdd:cd09720   74 QLLPfyghhrslkRLKLQIKWSDP--FKKRLWQKIIKQKILNQAFVL-EKLGIFEDAEKLKNLANKV----ESG---DKT 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 800309297 153 GFEGNAAKAYFTALghlVPQEFAfqgRSTRppLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASD 232
Cdd:cd09720  144 NREAHAAKLYFKTL---FGEDFS---RDDN--GDPINAALNYGYSILRSAVARALVKAGLLPRLGIFHKSEYNPFNLADD 215
                        250       260
                 ....*....|....*....|....
gi 800309297 233 LMEVWRaPIIDDTVLRLIADGVVD 256
Cdd:cd09720  216 LMEPFR-PLVDYLVYELLFESREE 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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