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Conserved domains on  [gi|674595118|emb|CDS26173|]
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expressed protein [Hymenolepis microstoma]

Protein Classification

PH domain-containing protein( domain architecture ID 10643714)

Pleckstrin homology (PH) domain-containing protein may be involved in targeting a protein to the appropriate cellular location or interacting with a binding partner

CATH:  2.30.29.30
Gene Ontology:  GO:0005515
PubMed:  22728242|17233582|15493994

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3416 super family cl47320
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
159-230 3.60e-05

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


The actual alignment was detected with superfamily member COG3416:

Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 44.63  E-value: 3.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 674595118 159 PGTF--GVFPGPSQPAgyPPMQPQPMGVPYggvpmQPVPPGAPPYGAYPQQPNAYPPPGVQPGPSYPGGvaGGF 230
Cdd:COG3416   82 SGGFlsGLFGGGQRPP--PAPQPSQPGPQQ-----QPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSGG--GGF 146
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 4-116 1.29e-03

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


:

Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 37.91  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674595118     4 VIKEGYIEIWSEE-NKSFRPIYAKLNSNGD--FQWQDAADSPYPIRSIDIKAVSAflafgavlnqvpRKPQSFTESDVDR 80
Cdd:smart00233   1 VIKEGWLYKKSGGgKKSWKKRYFVLFNSTLlyYKSKKDKKSYKPKGSIDLSGCTV------------REAPDPDSSKKPH 68

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 674595118    81 SFGIpheSNPDTVVTFFRCINKAEMGAWMECINKLL 116
Cdd:smart00233  69 CFEI---KTSDRKTLLLQAESEEEREKWVEALRKAI 101
 
Name Accession Description Interval E-value
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
159-230 3.60e-05

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 44.63  E-value: 3.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 674595118 159 PGTF--GVFPGPSQPAgyPPMQPQPMGVPYggvpmQPVPPGAPPYGAYPQQPNAYPPPGVQPGPSYPGGvaGGF 230
Cdd:COG3416   82 SGGFlsGLFGGGQRPP--PAPQPSQPGPQQ-----QPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSGG--GGF 146
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 123-247 2.69e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.72  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674595118  123 SQPQIVSQNVSAVSAGPYDSYGSYPPPQPNSGPPPLPGTFGVFPGPSQPAGYPP-------MQPQPMGVPYGGVPMQPVP 195
Cdd:pfam09770 210 PAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVtilqrpqSPQPDPAQPSIQPQAQQFH 289

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 674595118  196 PGAPPYGAYP----QQPNAyPPPGVQPGPSYPGGVAGGFYPGGHQPMVPGQQGLPQ 247
Cdd:pfam09770 290 QQPPPVPVQPtqilQNPNR-LSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAP 344
PHA03247 PHA03247
large tegument protein UL36; Provisional
 159-247 1.11e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674595118  159 PGTFGVFPGPSQPAGYPPMQPQPMGVPYGGVPMQPVPPgappygaYPQQPNAYPPPGVQPGPSYPGGVAGGFYPGGHQPM 238
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP-------PPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967


                  ....*....
gi 674595118  239 VPGQQGLPQ 247
Cdd:PHA03247 2968 VPGRVAVPR 2976
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 175-249 1.22e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.56  E-value: 1.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 674595118  175 PPMQPQPMGVPYGGVPMQPVPPGAPPYGAYPQQPNAYPPPGVQPGPSYPGGVAGgfyPGGHQPMVPGQQGLPQNV 249
Cdd:TIGR01628 380 PRMRQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLAPMNAVRAPSRNAQ 451
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 4-116 1.29e-03

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 37.91  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674595118     4 VIKEGYIEIWSEE-NKSFRPIYAKLNSNGD--FQWQDAADSPYPIRSIDIKAVSAflafgavlnqvpRKPQSFTESDVDR 80
Cdd:smart00233   1 VIKEGWLYKKSGGgKKSWKKRYFVLFNSTLlyYKSKKDKKSYKPKGSIDLSGCTV------------REAPDPDSSKKPH 68

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 674595118    81 SFGIpheSNPDTVVTFFRCINKAEMGAWMECINKLL 116
Cdd:smart00233  69 CFEI---KTSDRKTLLLQAESEEEREKWVEALRKAI 101
 
Name Accession Description Interval E-value
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
159-230 3.60e-05

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 44.63  E-value: 3.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 674595118 159 PGTF--GVFPGPSQPAgyPPMQPQPMGVPYggvpmQPVPPGAPPYGAYPQQPNAYPPPGVQPGPSYPGGvaGGF 230
Cdd:COG3416   82 SGGFlsGLFGGGQRPP--PAPQPSQPGPQQ-----QPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSGG--GGF 146
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 123-247 2.69e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.72  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674595118  123 SQPQIVSQNVSAVSAGPYDSYGSYPPPQPNSGPPPLPGTFGVFPGPSQPAGYPP-------MQPQPMGVPYGGVPMQPVP 195
Cdd:pfam09770 210 PAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVtilqrpqSPQPDPAQPSIQPQAQQFH 289

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 674595118  196 PGAPPYGAYP----QQPNAyPPPGVQPGPSYPGGVAGGFYPGGHQPMVPGQQGLPQ 247
Cdd:pfam09770 290 QQPPPVPVQPtqilQNPNR-LSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAP 344
PHA03247 PHA03247
large tegument protein UL36; Provisional
 159-247 1.11e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674595118  159 PGTFGVFPGPSQPAGYPPMQPQPMGVPYGGVPMQPVPPgappygaYPQQPNAYPPPGVQPGPSYPGGVAGGFYPGGHQPM 238
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP-------PPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGAL 2967


                  ....*....
gi 674595118  239 VPGQQGLPQ 247
Cdd:PHA03247 2968 VPGRVAVPR 2976
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 175-249 1.22e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.56  E-value: 1.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 674595118  175 PPMQPQPMGVPYGGVPMQPVPPGAPPYGAYPQQPNAYPPPGVQPGPSYPGGVAGgfyPGGHQPMVPGQQGLPQNV 249
Cdd:TIGR01628 380 PRMRQLPMGSPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLAPMNAVRAPSRNAQ 451
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 4-116 1.29e-03

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 37.91  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674595118     4 VIKEGYIEIWSEE-NKSFRPIYAKLNSNGD--FQWQDAADSPYPIRSIDIKAVSAflafgavlnqvpRKPQSFTESDVDR 80
Cdd:smart00233   1 VIKEGWLYKKSGGgKKSWKKRYFVLFNSTLlyYKSKKDKKSYKPKGSIDLSGCTV------------REAPDPDSSKKPH 68

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 674595118    81 SFGIpheSNPDTVVTFFRCINKAEMGAWMECINKLL 116
Cdd:smart00233  69 CFEI---KTSDRKTLLLQAESEEEREKWVEALRKAI 101
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 166-229 2.46e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 39.72  E-value: 2.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 674595118 166 PGPSQPAGYPPMQPQPMGVPYGGVPMQPVPPGAPPYGAYP----QQPNAYPPPGVQPGPSYPGGVAGG 229
Cdd:PRK14965 382 PAPPSAAWGAPTPAAPAAPPPAAAPPVPPAAPARPAAARPapapAPPAAAAPPARSADPAAAASAGDR 449
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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