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Conserved domains on  [gi|524688476|emb|CDD93796|]
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conserved hypothetical membrane protein [Akkermansia sp. CAG:344]

Protein Classification

vWA domain-containing protein( domain architecture ID 10541096)

vWA (von Willebrand factor type A) domain-containing protein with an aerotolerance regulator N-terminal domain; may be involved in one of a wide variety of important cellular functions, including basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and immune defenses

CATH:  3.40.50.410
PubMed:  12579041|10830113|12388743
SCOP:  3000832

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BatA pfam07584
Aerotolerance regulator N-terminal; These proteins share a highly-conserved sequence at their ...
 1-76 9.57e-21

Aerotolerance regulator N-terminal; These proteins share a highly-conserved sequence at their N-terminus. They include several proteins from Rhodopirellula baltica and also several from proteobacteria. The proteins are produced by the Batl operon which appears to be important in pathogenicity and aerotolerance. This family is the conserved N-terminus, but the full length proteins carry multiple membrane-spanning domains. BatA ensures bacterial survival in the early stages of the infection process, when the infected sites are aerobic, and is produced under conditions of oxidative stress.


:

Pssm-ID: 429551 [Multi-domain]  Cd Length: 76  Bit Score: 86.43  E-value: 9.57e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 524688476    1 MSFTSPWLLWALFAASIPIIIHLVNRWRHRSVHWAAMEFLLRAARETRGTKKLLHYLILALRVLAVAALVTAFARP 76
Cdd:pfam07584   1 MSFLNPLLLWALLLLPLPILLHYLLRRRPRRVPFPSLRLLKGLPRRLRRRSRLRPWLLLLLRLLALALLILALARP 76
VWA_2 pfam13519
von Willebrand factor type A domain;
92-179 5.09e-03

von Willebrand factor type A domain;


:

Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 36.89  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524688476   92 VLLVLDRSASMDARPDKTNSLRDAIpPLVESTFAQLGHCRLSLLDSATGTVTQIP----APEALADLTVSKTTDGGADIP 167
Cdd:pfam13519   1 LVFVLDTSGSMRNGDYGPTRLEAAK-DAVLALLKSLPGDRVGLVTFGDGPEVLIPltkdRAKILRALRRLEPKGGGTNLA 79

                          90
                  ....*....|..
gi 524688476  168 ALLQKAIPYLEE 179
Cdd:pfam13519  80 AALQLARAALKH 91
 
Name Accession Description Interval E-value
BatA pfam07584
Aerotolerance regulator N-terminal; These proteins share a highly-conserved sequence at their ...
 1-76 9.57e-21

Aerotolerance regulator N-terminal; These proteins share a highly-conserved sequence at their N-terminus. They include several proteins from Rhodopirellula baltica and also several from proteobacteria. The proteins are produced by the Batl operon which appears to be important in pathogenicity and aerotolerance. This family is the conserved N-terminus, but the full length proteins carry multiple membrane-spanning domains. BatA ensures bacterial survival in the early stages of the infection process, when the infected sites are aerobic, and is produced under conditions of oxidative stress.


Pssm-ID: 429551 [Multi-domain]  Cd Length: 76  Bit Score: 86.43  E-value: 9.57e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 524688476    1 MSFTSPWLLWALFAASIPIIIHLVNRWRHRSVHWAAMEFLLRAARETRGTKKLLHYLILALRVLAVAALVTAFARP 76
Cdd:pfam07584   1 MSFLNPLLLWALLLLPLPILLHYLLRRRPRRVPFPSLRLLKGLPRRLRRRSRLRPWLLLLLRLLALALLILALARP 76
two_anch TIGR02226
N-terminal double-transmembrane domain; This model represents a prokaryotic N-terminal region ...
 1-80 3.65e-19

N-terminal double-transmembrane domain; This model represents a prokaryotic N-terminal region of about 80 amino acids. The predicted membrane topology by TMHMM puts the N-terminus outside and spans the membrane twice, with a cytosolic region of about 25 amino acids between the two transmembrane regions. Member proteins tend to be between 600 and 1000 amino acids in length. [Hypothetical proteins, Domain]


Pssm-ID: 131281  Cd Length: 82  Bit Score: 82.40  E-value: 3.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524688476    1 MSFTSPWLLWALFAASIPIIIHLVNRWRHRSVHWAAMEFLLRAARETRGTKKLLHYLILALRVLAVAALVTAFARPLLSS 80
Cdd:TIGR02226   1 MSFLNPALLAGLLAAVLPLLIHLLRRRPPRPVDFPALRFLREVPKRERSRSRLDQWWLLALRLLALAALAIALARPLLNP 80
VWA_2 pfam13519
von Willebrand factor type A domain;
92-179 5.09e-03

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 36.89  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524688476   92 VLLVLDRSASMDARPDKTNSLRDAIpPLVESTFAQLGHCRLSLLDSATGTVTQIP----APEALADLTVSKTTDGGADIP 167
Cdd:pfam13519   1 LVFVLDTSGSMRNGDYGPTRLEAAK-DAVLALLKSLPGDRVGLVTFGDGPEVLIPltkdRAKILRALRRLEPKGGGTNLA 79

                          90
                  ....*....|..
gi 524688476  168 ALLQKAIPYLEE 179
Cdd:pfam13519  80 AALQLARAALKH 91
ViaA COG2425
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ...
 6-217 9.13e-03

Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown];


Pssm-ID: 441973 [Multi-domain]  Cd Length: 263  Bit Score: 38.51  E-value: 9.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524688476   6 PWLLWALFAASIPIIIHLVN----RWRHRSVHWAAMEFLLRAARETRGTKKLLHYLILALRVLAVAALVTAFARPLLssf 81
Cdd:COG2425   43 RAALLALLLLLLRAALALLTllagLVLLALDALLLAALLAALLDALLLAVLLLALLLLAALLLLAAPASAAVPLLEG--- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524688476  82 fgwgssglnEVLLVLDRSASMDArpDKTNSLRDAIPPLVESTFAQLgHCRLSLLDSA---TGTVTQIPAPEALADLTVSK 158
Cdd:COG2425  120 ---------PVVLCVDTSGSMAG--SKEAAAKAAALALLRALRPNR-RFGVILFDTEvveDLPLTADDGLEDAIEFLSGL 187

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 524688476 159 TTDGGADIPALLQKAIPYLEESGSGKTEIWIASDMQAssWRPDSPLWPGVRQ-----RLAALAI 217
Cdd:COG2425  188 FAGGGTDIAPALRAALELLEEPDYRNADIVLITDGEA--GVSPEELLREVRAkesgvRLFTVAI 249
 
Name Accession Description Interval E-value
BatA pfam07584
Aerotolerance regulator N-terminal; These proteins share a highly-conserved sequence at their ...
 1-76 9.57e-21

Aerotolerance regulator N-terminal; These proteins share a highly-conserved sequence at their N-terminus. They include several proteins from Rhodopirellula baltica and also several from proteobacteria. The proteins are produced by the Batl operon which appears to be important in pathogenicity and aerotolerance. This family is the conserved N-terminus, but the full length proteins carry multiple membrane-spanning domains. BatA ensures bacterial survival in the early stages of the infection process, when the infected sites are aerobic, and is produced under conditions of oxidative stress.


Pssm-ID: 429551 [Multi-domain]  Cd Length: 76  Bit Score: 86.43  E-value: 9.57e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 524688476    1 MSFTSPWLLWALFAASIPIIIHLVNRWRHRSVHWAAMEFLLRAARETRGTKKLLHYLILALRVLAVAALVTAFARP 76
Cdd:pfam07584   1 MSFLNPLLLWALLLLPLPILLHYLLRRRPRRVPFPSLRLLKGLPRRLRRRSRLRPWLLLLLRLLALALLILALARP 76
two_anch TIGR02226
N-terminal double-transmembrane domain; This model represents a prokaryotic N-terminal region ...
 1-80 3.65e-19

N-terminal double-transmembrane domain; This model represents a prokaryotic N-terminal region of about 80 amino acids. The predicted membrane topology by TMHMM puts the N-terminus outside and spans the membrane twice, with a cytosolic region of about 25 amino acids between the two transmembrane regions. Member proteins tend to be between 600 and 1000 amino acids in length. [Hypothetical proteins, Domain]


Pssm-ID: 131281  Cd Length: 82  Bit Score: 82.40  E-value: 3.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524688476    1 MSFTSPWLLWALFAASIPIIIHLVNRWRHRSVHWAAMEFLLRAARETRGTKKLLHYLILALRVLAVAALVTAFARPLLSS 80
Cdd:TIGR02226   1 MSFLNPALLAGLLAAVLPLLIHLLRRRPPRPVDFPALRFLREVPKRERSRSRLDQWWLLALRLLALAALAIALARPLLNP 80
VWA_2 pfam13519
von Willebrand factor type A domain;
92-179 5.09e-03

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 36.89  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524688476   92 VLLVLDRSASMDARPDKTNSLRDAIpPLVESTFAQLGHCRLSLLDSATGTVTQIP----APEALADLTVSKTTDGGADIP 167
Cdd:pfam13519   1 LVFVLDTSGSMRNGDYGPTRLEAAK-DAVLALLKSLPGDRVGLVTFGDGPEVLIPltkdRAKILRALRRLEPKGGGTNLA 79

                          90
                  ....*....|..
gi 524688476  168 ALLQKAIPYLEE 179
Cdd:pfam13519  80 AALQLARAALKH 91
ViaA COG2425
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ...
 6-217 9.13e-03

Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown];


Pssm-ID: 441973 [Multi-domain]  Cd Length: 263  Bit Score: 38.51  E-value: 9.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524688476   6 PWLLWALFAASIPIIIHLVN----RWRHRSVHWAAMEFLLRAARETRGTKKLLHYLILALRVLAVAALVTAFARPLLssf 81
Cdd:COG2425   43 RAALLALLLLLLRAALALLTllagLVLLALDALLLAALLAALLDALLLAVLLLALLLLAALLLLAAPASAAVPLLEG--- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 524688476  82 fgwgssglnEVLLVLDRSASMDArpDKTNSLRDAIPPLVESTFAQLgHCRLSLLDSA---TGTVTQIPAPEALADLTVSK 158
Cdd:COG2425  120 ---------PVVLCVDTSGSMAG--SKEAAAKAAALALLRALRPNR-RFGVILFDTEvveDLPLTADDGLEDAIEFLSGL 187

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 524688476 159 TTDGGADIPALLQKAIPYLEESGSGKTEIWIASDMQAssWRPDSPLWPGVRQ-----RLAALAI 217
Cdd:COG2425  188 FAGGGTDIAPALRAALELLEEPDYRNADIVLITDGEA--GVSPEELLREVRAkesgvRLFTVAI 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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