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Conserved domains on  [gi|374255386|emb|CCF77257|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain and ankyrin repeat-containing protein( domain architecture ID 13033757)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain and ankyrin (ANK) repeat-containing protein similar to Arabidopsis thaliana regulatory proteins NPR1/NIM1 and NPR2; also contains an NPR1/NIM1 like defense protein C-terminal domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPR1_like_C pfam12313
NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. ...
 370-573 4.90e-108

NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with pfam00023, pfam00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.


:

Pssm-ID: 372037  Cd Length: 204  Bit Score: 323.08  E-value: 4.90e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  370 KRLTKADDYKTSTEDGTPSLKGGLCIEVLEHEQKLEYLsPIEASLSLPVTPEELRMRLLYYENRVALARLLFPVETETVQ 449
Cdd:pfam12313   1 KRLTRAKDYNTSTEQGKESPKDRLCIEILEQEERRNPL-PGEASVSLAMAADDLRMRLLYLENRVALARLLFPAEAKVAM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  450 GIAKLEETCEFTASSLEPDHHIGEKRTSLDLNMAPFQIHEKHLSRLRALCKTVELGKRYFKRCS--LDHFMDtEDLNHLA 527
Cdd:pfam12313  80 DIAQVDGTSEFTGSSSSPSKGTGGKRTAVDLNETPFKQKEEHLSRMRALSKTVELGKRFFPRCSevLDKFMD-DDLPDLA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 374255386  528 SVEEDTPEKRLQKKQRYMELQETLMKTFSEDKEECGKSSTPKPTSA 573
Cdd:pfam12313 159 FLEKGTPEEQRQKRQRFMELQEDVQKAFSKDKEEKAKSSLSSSSSS 204
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 50-194 7.87e-74

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 232.58  E-value: 7.87e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  50 KLLSNCLESVFDSPETFYSDAKLVLAGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQLKEIARDYEVGFDSVV 129
Cdd:cd18310    1 KKLSSDLENLLDSPDLFYSDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIPGGIVGYDAFM 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 374255386 130 AVLAYVYSGRVRSPPKGASACVDDDCCHVACRSKVDFMVEVLYLSFVFQIQELVTLYERQFLEIV 194
Cdd:cd18310   81 LVLSYLYSGRLRLVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
270-387 6.17e-14

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 6.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386 270 IYKALDSDDVELVKMLLLEG----HTNLDEAYALHFAIAHCAVKTAYDLLELElADVNLRNPRGYTVLHVAAMRKEPKLI 345
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGadvnARDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIV 169

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 374255386 346 ISLLMKGANILDTTLDGRTALV---------IVKRL--TKADDYKTSTEDGTP 387
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHlaaenghleIVKLLleAGADVNAKDNDGKTA 222
DUF3420 super family cl13357
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
 231-271 2.01e-08

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


The actual alignment was detected with superfamily member pfam11900:

Pssm-ID: 314729  Cd Length: 47  Bit Score: 50.49  E-value: 2.01e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 374255386  231 DIELVSLEKSLPQHIFKQIIDIREALCLEP------PKLERHVKNIY 271
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLPSlspeldDLLEKRVRRIL 47
 
Name Accession Description Interval E-value
NPR1_like_C pfam12313
NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. ...
 370-573 4.90e-108

NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with pfam00023, pfam00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.


Pssm-ID: 372037  Cd Length: 204  Bit Score: 323.08  E-value: 4.90e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  370 KRLTKADDYKTSTEDGTPSLKGGLCIEVLEHEQKLEYLsPIEASLSLPVTPEELRMRLLYYENRVALARLLFPVETETVQ 449
Cdd:pfam12313   1 KRLTRAKDYNTSTEQGKESPKDRLCIEILEQEERRNPL-PGEASVSLAMAADDLRMRLLYLENRVALARLLFPAEAKVAM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  450 GIAKLEETCEFTASSLEPDHHIGEKRTSLDLNMAPFQIHEKHLSRLRALCKTVELGKRYFKRCS--LDHFMDtEDLNHLA 527
Cdd:pfam12313  80 DIAQVDGTSEFTGSSSSPSKGTGGKRTAVDLNETPFKQKEEHLSRMRALSKTVELGKRFFPRCSevLDKFMD-DDLPDLA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 374255386  528 SVEEDTPEKRLQKKQRYMELQETLMKTFSEDKEECGKSSTPKPTSA 573
Cdd:pfam12313 159 FLEKGTPEEQRQKRQRFMELQEDVQKAFSKDKEEKAKSSLSSSSSS 204
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 50-194 7.87e-74

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 232.58  E-value: 7.87e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  50 KLLSNCLESVFDSPETFYSDAKLVLAGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQLKEIARDYEVGFDSVV 129
Cdd:cd18310    1 KKLSSDLENLLDSPDLFYSDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIPGGIVGYDAFM 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 374255386 130 AVLAYVYSGRVRSPPKGASACVDDDCCHVACRSKVDFMVEVLYLSFVFQIQELVTLYERQFLEIV 194
Cdd:cd18310   81 LVLSYLYSGRLRLVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
270-387 6.17e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 6.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386 270 IYKALDSDDVELVKMLLLEG----HTNLDEAYALHFAIAHCAVKTAYDLLELElADVNLRNPRGYTVLHVAAMRKEPKLI 345
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGadvnARDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIV 169

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 374255386 346 ISLLMKGANILDTTLDGRTALV---------IVKRL--TKADDYKTSTEDGTP 387
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHlaaenghleIVKLLleAGADVNAKDNDGKTA 222
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
 231-271 2.01e-08

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


Pssm-ID: 314729  Cd Length: 47  Bit Score: 50.49  E-value: 2.01e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 374255386  231 DIELVSLEKSLPQHIFKQIIDIREALCLEP------PKLERHVKNIY 271
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLPSlspeldDLLEKRVRRIL 47
Ank_2 pfam12796
Ankyrin repeats (3 copies);
273-355 4.43e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 4.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  273 ALDSDDVELVKMLLLEGH----TNLDEAYALHFAIAHCAVKTAyDLLeLELADVNLRNpRGYTVLHVAAMRKEPKLIISL 348
Cdd:pfam12796   4 AAKNGNLELVKLLLENGAdanlQDKNGRTALHLAAKNGHLEIV-KLL-LEHADVNLKD-NGRTALHYAARSGHLEIVKLL 80


                  ....*..
gi 374255386  349 LMKGANI 355
Cdd:pfam12796  81 LEKGADI 87
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 64-188 1.25e-06

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 47.25  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386   64 ETFYSDAKLVlAGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQlkeiardyEVGFDSVVAVLAYVYSGRVRSP 143
Cdd:pfam00651   7 QGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLD--------DVSPEDFEALLEFMYTGKLISE 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 374255386  144 PKgasacvdddcchvacrskvdfMVEVLYLSFVFQIQELVTLYER 188
Cdd:pfam00651  78 EN---------------------VDDLLAAADKLQIPSLVDKCEE 101
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 69-192 1.31e-05

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 44.22  E-value: 1.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386    69 DAKLVlAGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQlkeiardyEVGFDSVVAVLAYVYSGRVRSPPKgas 148
Cdd:smart00225   1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD--------DVSPEDFRALLNFLYTGKLDLPEE--- 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 374255386   149 aCVDddcchvacrskvdfmvEVLYLSFVFQIQELVTLYERQFLE 192
Cdd:smart00225  69 -NVE----------------ELLELADYLQIPGLVELCEEFLLK 95
PHA03095 PHA03095
ankyrin-like protein; Provisional
 291-366 1.70e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.25  E-value: 1.70e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 374255386 291 TNLDEAYALHFAIAHCAVKTAY--DLLElELADVNLRNPRGYTVLHVAAMRKEPKLIISLLMKGANILDTTLDGRTAL 366
Cdd:PHA03095 218 TDMLGNTPLHSMATGSSCKRSLvlPLLI-AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
 
Name Accession Description Interval E-value
NPR1_like_C pfam12313
NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. ...
 370-573 4.90e-108

NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with pfam00023, pfam00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.


Pssm-ID: 372037  Cd Length: 204  Bit Score: 323.08  E-value: 4.90e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  370 KRLTKADDYKTSTEDGTPSLKGGLCIEVLEHEQKLEYLsPIEASLSLPVTPEELRMRLLYYENRVALARLLFPVETETVQ 449
Cdd:pfam12313   1 KRLTRAKDYNTSTEQGKESPKDRLCIEILEQEERRNPL-PGEASVSLAMAADDLRMRLLYLENRVALARLLFPAEAKVAM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  450 GIAKLEETCEFTASSLEPDHHIGEKRTSLDLNMAPFQIHEKHLSRLRALCKTVELGKRYFKRCS--LDHFMDtEDLNHLA 527
Cdd:pfam12313  80 DIAQVDGTSEFTGSSSSPSKGTGGKRTAVDLNETPFKQKEEHLSRMRALSKTVELGKRFFPRCSevLDKFMD-DDLPDLA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 374255386  528 SVEEDTPEKRLQKKQRYMELQETLMKTFSEDKEECGKSSTPKPTSA 573
Cdd:pfam12313 159 FLEKGTPEEQRQKRQRFMELQEDVQKAFSKDKEEKAKSSLSSSSSS 204
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 50-194 7.87e-74

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 232.58  E-value: 7.87e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  50 KLLSNCLESVFDSPETFYSDAKLVLAGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQLKEIARDYEVGFDSVV 129
Cdd:cd18310    1 KKLSSDLENLLDSPDLFYSDAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIPGGIVGYDAFM 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 374255386 130 AVLAYVYSGRVRSPPKGASACVDDDCCHVACRSKVDFMVEVLYLSFVFQIQELVTLYERQFLEIV 194
Cdd:cd18310   81 LVLSYLYSGRLRLVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
270-387 6.17e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 6.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386 270 IYKALDSDDVELVKMLLLEG----HTNLDEAYALHFAIAHCAVKTAYDLLELElADVNLRNPRGYTVLHVAAMRKEPKLI 345
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGadvnARDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIV 169

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 374255386 346 ISLLMKGANILDTTLDGRTALV---------IVKRL--TKADDYKTSTEDGTP 387
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHlaaenghleIVKLLleAGADVNAKDNDGKTA 222
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
270-366 9.60e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.21  E-value: 9.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386 270 IYKALDSDDVELVKMLLLEG----HTNLDEAYALHFAIAHCAVKTAYDLLELElADVNLRNPRGYTVLHVAAMRKEPKLI 345
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLEAGadvnAQDNDGNTPLHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIV 202

                         90       100
                 ....*....|....*....|.
gi 374255386 346 ISLLMKGANILDTTLDGRTAL 366
Cdd:COG0666  203 KLLLEAGADVNAKDNDGKTAL 223
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
270-387 7.29e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.35  E-value: 7.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386 270 IYKALDSDDVELVKMLLLEGH----TNLDEAYALHFAIAHCAVKTAYDLLELElADVNLRNPRGYTVLHVAAMRKEPKLI 345
Cdd:COG0666   58 LLAAALAGDLLVALLLLAAGAdinaKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 374255386 346 ISLLMKGANILDTTLDGRTALV---------IVKRL--TKADDYKTSTEDGTP 387
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTPLHlaaangnleIVKLLleAGADVNARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
273-379 2.91e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 2.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386 273 ALDSDDVELVKMLLLEG----HTNLDEAYALHFAIAHCAVKTAYDLLELElADVNLRNPRGYTVLHVAAMRKEPKLIISL 348
Cdd:COG0666  160 AAANGNLEIVKLLLEAGadvnARDNDGETPLHLAAENGHLEIVKLLLEAG-ADVNAKDNDGKTALDLAAENGNLEIVKLL 238

                         90       100       110
                 ....*....|....*....|....*....|.
gi 374255386 349 LMKGANILDTTLDGRTALVIVKRLTKADDYK 379
Cdd:COG0666  239 LEAGADLNAKDKDGLTALLLAAAAGAALIVK 269
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
 231-271 2.01e-08

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


Pssm-ID: 314729  Cd Length: 47  Bit Score: 50.49  E-value: 2.01e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 374255386  231 DIELVSLEKSLPQHIFKQIIDIREALCLEP------PKLERHVKNIY 271
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLPSlspeldDLLEKRVRRIL 47
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 56-140 1.96e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 49.55  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  56 LESVFDSPEtfYSDAK-LVLAGGREVSFHRCILSARIPVFKSALATvKEQKSSTTVKLQLKEIarDYEVgfdsVVAVLAY 134
Cdd:cd18294    5 MKSLINNPE--FSDVKfLVGPERQEIFAHKCILAARCEVFRAMFLT-GPQKESTQSPLVLSDI--EPEV----FRAVLEF 75


                 ....*.
gi 374255386 135 VYSGRV 140
Cdd:cd18294   76 IYTNCV 81
Ank_2 pfam12796
Ankyrin repeats (3 copies);
273-355 4.43e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 4.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  273 ALDSDDVELVKMLLLEGH----TNLDEAYALHFAIAHCAVKTAyDLLeLELADVNLRNpRGYTVLHVAAMRKEPKLIISL 348
Cdd:pfam12796   4 AAKNGNLELVKLLLENGAdanlQDKNGRTALHLAAKNGHLEIV-KLL-LEHADVNLKD-NGRTALHYAARSGHLEIVKLL 80


                  ....*..
gi 374255386  349 LMKGANI 355
Cdd:pfam12796  81 LEKGADI 87
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-140 1.11e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 46.78  E-value: 1.11e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 374255386  67 YSDAKLVlAGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQlkeiardyEVGFDSVVAVLAYVYSGRV 140
Cdd:cd18186    1 LCDVTLV-VGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELD--------DVSPEAFEALLDYIYTGEL 65
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 64-188 1.25e-06

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 47.25  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386   64 ETFYSDAKLVlAGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQlkeiardyEVGFDSVVAVLAYVYSGRVRSP 143
Cdd:pfam00651   7 QGELCDVTLV-VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLD--------DVSPEDFEALLEFMYTGKLISE 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 374255386  144 PKgasacvdddcchvacrskvdfMVEVLYLSFVFQIQELVTLYER 188
Cdd:pfam00651  78 EN---------------------VDDLLAAADKLQIPSLVDKCEE 101
Ank_2 pfam12796
Ankyrin repeats (3 copies);
299-366 2.52e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 2.52e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 374255386  299 LHFAIAHCAVKTAYDLLELElADVNLRNPRGYTVLHVAAMRKEPKlIISLLMKGANIlDTTLDGRTAL 366
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLE-IVKLLLEHADV-NLKDNGRTAL 65
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
263-387 3.11e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.18  E-value: 3.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386 263 LERHVKNIYKALDSDDVELVKMLLLEGHTNLDEAYALHFAIAHCAVKTAYDLLELELADVNLRNPRGYTVLHVAAMRKEP 342
Cdd:COG0666   21 LALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDL 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 374255386 343 KLIISLLMKGANILDTTLDGRTALV---------IVKRLTK--ADDYKTSTEDGTP 387
Cdd:COG0666  101 EIVKLLLEAGADVNARDKDGETPLHlaayngnleIVKLLLEagADVNAQDNDGNTP 156
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-140 4.73e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 46.08  E-value: 4.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  45 EVSALKLLSNCLESVFDSPEtfYSDAKLVLaGGREVSFHRCILSARIPVFKSALAT-VKEqksSTTVKLQLKEIARdyeV 123
Cdd:cd18287    2 EIDHVHFLSEDIGALFLNEE--YSDVTFVV-EEKRFPAHRVILAARSEYFRALLYGgMRE---SQQSEIELKDTNA---E 72

                         90
                 ....*....|....*..
gi 374255386 124 GFDsvvAVLAYVYSGRV 140
Cdd:cd18287   73 AFK---ALLKYIYTGRL 86
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 69-192 1.31e-05

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 44.22  E-value: 1.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386    69 DAKLVlAGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQlkeiardyEVGFDSVVAVLAYVYSGRVRSPPKgas 148
Cdd:smart00225   1 DVTLV-VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD--------DVSPEDFRALLNFLYTGKLDLPEE--- 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 374255386   149 aCVDddcchvacrskvdfmvEVLYLSFVFQIQELVTLYERQFLE 192
Cdd:smart00225  69 -NVE----------------ELLELADYLQIPGLVELCEEFLLK 95
Ank_5 pfam13857
Ankyrin repeats (many copies);
314-366 8.36e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 8.36e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 374255386  314 LLELELADVNLRNPRGYTVLHVAAMRKEPKLIISLLMKGANILDTTLDGRTAL 366
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 291-366 1.70e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.25  E-value: 1.70e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 374255386 291 TNLDEAYALHFAIAHCAVKTAY--DLLElELADVNLRNPRGYTVLHVAAMRKEPKLIISLLMKGANILDTTLDGRTAL 366
Cdd:PHA03095 218 TDMLGNTPLHSMATGSSCKRSLvlPLLI-AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-161 1.17e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 39.15  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  35 DYPTEFLtppevsalkllSNCLESvfdspeTFYSDAKLVLAGgREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQL 114
Cdd:cd18295    4 DYYDEFL-----------RRLLEQ------GSYSDVTFNVHG-ESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPL 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 374255386 115 keiardyeVGFDSVVAVLAYVYSGRVRSPpkgasacVD--DDCCHVA--CR 161
Cdd:cd18295   66 --------VNPDAFRALLQYLYTGRLEIH-------VDdvEDCKRLAkqCR 101
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 67-141 1.81e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 38.09  E-value: 1.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 374255386  67 YSDAKLVLaGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQlkeiardyEVGFDSVVAVLAYVYSGRVR 141
Cdd:cd18314    6 FSDVVLCV-GDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLE--------DVEPEIFETVLKYMYTGQVT 71
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-156 4.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 37.23  E-value: 4.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  54 NCLESVFDSPETfySDAKLVLaGGREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQlkeiARDYEVGFdsvvAVLA 133
Cdd:cd18298    1 DSLRKAFNDPRT--SDLKFRV-DGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEID----QYSYPVYY----AFLR 69

                         90       100
                 ....*....|....*....|...
gi 374255386 134 YVYSGRVRSPPKGASACVDDDCC 156
Cdd:cd18298   70 YLYTDQVDLPPEDAIGLLDLANS 92
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-150 7.86e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 36.86  E-value: 7.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 374255386  51 LLSNCLESVFDSPetFYSDAKLVLAGgREVSFHRCILSARIPVFKSALATVKEQKSSTTVKLQlkeiardyEVGFDSVVA 130
Cdd:cd18344    9 MLTDDLGELWENS--LFTDCCLLVAG-HEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIH--------DLDPQVFKE 77

                         90       100
                 ....*....|....*....|
gi 374255386 131 VLAYVYSGRVRSPPKGASAC 150
Cdd:cd18344   78 MMGFIYTGKAPHLHSHSMAC 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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