NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|373220497|emb|CCD73995|]
View 

Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 12-315 5.40e-113

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 330.19  E-value: 5.40e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   12 QCSSLICAIVFNSLLIYLIITKSPKKMGNYKALMIYFSTFSMVFAVIDMIVQPFIHSYGSCFFMIMSIKDWPFTVEMAQI 91
Cdd:pfam10326   5 QYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   92 ALSILCGCGGVTPFLIAIHFIYRFFALERKGNLKYFSGTYLFMWFLIPIAGGINWFHLSWFYYRRNDKTTEYIKEAVLEN 171
Cdd:pfam10326  85 LLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLEN 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497  172 FGLHMNETVYSAALFYPADEHGVPNLDIKIFISYVILSFSMVIPFAVMLVAGVKSHSQIKKLIEQGeCDYTKRLQLQLYK 251
Cdd:pfam10326 165 YNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQLFK 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 373220497  252 ALLVQTFLPIFLFFMPMGALFSAPLFHIDIGSWSYLTTYLYALYPAVDPLPIMFIVQEYRNAFI 315
Cdd:pfam10326 244 ALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 12-315 5.40e-113

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 330.19  E-value: 5.40e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   12 QCSSLICAIVFNSLLIYLIITKSPKKMGNYKALMIYFSTFSMVFAVIDMIVQPFIHSYGSCFFMIMSIKDWPFTVEMAQI 91
Cdd:pfam10326   5 QYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   92 ALSILCGCGGVTPFLIAIHFIYRFFALERKGNLKYFSGTYLFMWFLIPIAGGINWFHLSWFYYRRNDKTTEYIKEAVLEN 171
Cdd:pfam10326  85 LLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLEN 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497  172 FGLHMNETVYSAALFYPADEHGVPNLDIKIFISYVILSFSMVIPFAVMLVAGVKSHSQIKKLIEQGeCDYTKRLQLQLYK 251
Cdd:pfam10326 165 YNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQLFK 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 373220497  252 ALLVQTFLPIFLFFMPMGALFSAPLFHIDIGSWSYLTTYLYALYPAVDPLPIMFIVQEYRNAFI 315
Cdd:pfam10326 244 ALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 12-315 5.40e-113

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 330.19  E-value: 5.40e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   12 QCSSLICAIVFNSLLIYLIITKSPKKMGNYKALMIYFSTFSMVFAVIDMIVQPFIHSYGSCFFMIMSIKDWPFTVEMAQI 91
Cdd:pfam10326   5 QYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   92 ALSILCGCGGVTPFLIAIHFIYRFFALERKGNLKYFSGTYLFMWFLIPIAGGINWFHLSWFYYRRNDKTTEYIKEAVLEN 171
Cdd:pfam10326  85 LLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLEN 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497  172 FGLHMNETVYSAALFYPADEHGVPNLDIKIFISYVILSFSMVIPFAVMLVAGVKSHSQIKKLIEQGeCDYTKRLQLQLYK 251
Cdd:pfam10326 165 YNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQLFK 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 373220497  252 ALLVQTFLPIFLFFMPMGALFSAPLFHIDIGSWSYLTTYLYALYPAVDPLPIMFIVQEYRNAFI 315
Cdd:pfam10326 244 ALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 17-314 3.70e-48

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 164.34  E-value: 3.70e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   17 ICAIVFNSLLIYLIITKSPKKMGNYKALMIYFSTFSMVFAVIDMIVQPFIHSYGSCFFMImsIKDWPF--TVEMAQIALS 94
Cdd:pfam10319  16 VLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVF--VSDGPFfeYSELGQHALS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   95 ILCGCGGVTPFLIAIHFIYRFFALERKGNL-KYFSGTYLFMWFLIPIAGGINWFHLSWFYYRRNDKTTEYIKEAVLENFG 173
Cdd:pfam10319  94 ARCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497  174 LHMNETVYSAALFYPADEHGVPNLDIKIFISYVILSFSMVipfaVMLVAGVKSHSQIKKlIEQGECDYTKRLQLQLYKAL 253
Cdd:pfam10319 174 VDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSII----LYIVLGYKIMRKLNK-MSVTMSKKTKRLQKQLLKAL 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 373220497  254 LVQTFLPIFLFFMPMGALFSAPLFHIDIGSW-SYLTTYLYALYPAVDPLPIMFIVQEYRNAF 314
Cdd:pfam10319 249 IVQTIIPICISFSPCVLAWYSPIFGIDLGRWnNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 17-315 4.36e-12

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 65.65  E-value: 4.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   17 ICAIVFNSLLIYLIITKSPKKMGNYKALMIYFSTFSMVFAVIDMIVQP---------FIHSYGSCFFmimsikdwpFTVE 87
Cdd:pfam10317  10 ILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQriipngvsmALISYGPCKY---------FGPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   88 MAQIALSILCGCGGVTPFLIAIHFIYRFFALeRKGNLKYFSGTYLFMWFLIPIAgginwFHLSWFYYRRNDKTT-EYIKE 166
Cdd:pfam10317  81 FCYSGYSLLQHFLLHSGWSLLLTFYYRYYIL-KHVDPKRKKLILLIIIHYIPSL-----SQLIVIFLSPTDFLPvEALTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497  167 AVLENFGLHMNETVYSAALFYPAdehgvpnldikIFISYVILSFSMVIPFAVMLVAGVKSHSQIKKLiEQGECDYTKRLQ 246
Cdd:pfam10317 155 ELHPNYNLTDYTVTGFSDLQSFP-----------ALINTLIMTIPVFPIPIIILILRRKILKLLNSN-SVNMSPTTKAQH 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 373220497  247 LQLYKALLVQTFLPIFLFFMPMGALFSAPLFHIDIGSWSYLTTYLYALYPAVDPLPIMFIVQEYRNAFI 315
Cdd:pfam10317 223 RQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 17-318 1.69e-09

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 57.94  E-value: 1.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   17 ICAIVFNSLLIYLIITKSPKKMGNYKALMIYFSTFSMVFAV-IDMIVQPFIHSYGSCFFMIMSIKDWPFTVEmaqIALSI 95
Cdd:pfam10318  15 VISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLsLSFLTIPYIFLPALAGYPLGLLSYLGVPTP---IQFYI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497   96 LCGCGGVTPFLIAIHFIYRFFAL---ERKGNLKYFSGTYLFMWFLIPIAGGInwfhLSWFyyrrNDKTTEYIKEAVLENF 172
Cdd:pfam10318  92 GVTSLALVGVSIILLFENRYSILftnKKRITWKKTRVLYLIFNYIIALLFLI----PIYL----NIPDQEAAKLKVLKKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373220497  173 GLHMNETVYSAALFYPADEHGVPNLDIKIFISYVILSfsmVIPFAVMLVagVKSHSQIKKLIEQGecdyTKRLQLQLYKA 252
Cdd:pfam10318 164 PCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQ---ILFFVFLTI--YYLFKSVKSSLSKK----TRKLQKKFFIA 234

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 373220497  253 LLVQTFLPIFLFFMPMGALFSAPLFHIDIGSWSYLTTYLYALYPAVDPLPIMFIVQEYRNAFIELF 318
Cdd:pfam10318 235 LIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH