|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
75-514 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 652.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 75 VSHALVVIFLEYFAWGLLTVPVINVLAETFPTNKFLMNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPI 154
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 155 PCLKISPWWYFSLFSLSGLFSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATI 234
Cdd:cd17387 81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 235 VSVADVIFIVLFVPESLPSRRNTGSVSQITPnevfnWQSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYL 314
Cdd:cd17387 161 VALLDICFILLAVPESLPEKMRPASWGAPIS-----WEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 315 KLVVGFSPEAVAMYIGLVGILSVVAQTGFLHCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSITY 394
Cdd:cd17387 236 KQVMGFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITF 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 395 PSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLFDVDLEDEKSTGgalslvaprkipekilaptrness 474
Cdd:cd17387 316 PAISALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQ------------------------ 371
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 351064453 475 wIQQQVDRAAAFDWQFIPGPPFLIGAMMVLFALLINSTLP 514
Cdd:cd17387 372 -SSKQRMQNPSLEGAIIPGPPFLFGAISVLLAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
78-440 |
3.22e-55 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 189.71 E-value: 3.22e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLtVPVINVLAETF--PTNKFLMNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIP 155
Cdd:cd17330 1 LFLVVFLDALGFGIV-FPVLPFYVREFnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 156 CLKISP--WWYFSLFSLSGLFSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLAT 233
Cdd:cd17330 80 LLGLSRnlWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 234 IVSVADVIFIVLFVPeslpsrrntgsvsqitpnevfnwqsadpfgslrivwedkLVLQLATIVFLSYLPESGQFSCFFVY 313
Cdd:cd17330 160 ALALLNLVLVLFFLP---------------------------------------PLRRLLLVYFLIALAFAGLESVFSLF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 314 LKLVVGFSPEAVAMYIGLVGILSVVAQTGFLHCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQY-WMMWSAGVLAAMSSI 392
Cdd:cd17330 201 LKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVpLLVLAAAILAFGTGI 280
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 351064453 393 TYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLFD 440
Cdd:cd17330 281 VFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG 328
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
78-439 |
6.80e-42 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 154.72 E-value: 6.80e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLtVPVINVLAETF---PTNKFLMNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPI 154
Cdd:cd17388 4 ILVTVLLDAMGIGLI-MPVLPTLLREFvgdSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 155 PCLKISP--WWYFSLFSLSGLFSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEvYGDSLVVLLA 232
Cdd:cd17388 83 LLMAFAPtlWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 233 TIVSVADVIFIVLFVPESLPSRRNTGsvsqitpnevFNWQSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFV 312
Cdd:cd17388 162 AGLNGLNFLLGLFVLPESLPPERRRA----------FRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 313 YLKLVVGFSPEAVAMYIGLVGILSVVAQTGFLHCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSI 392
Cdd:cd17388 232 FTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGI 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 351064453 393 TYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLF 439
Cdd:cd17388 312 AGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
79-439 |
7.25e-34 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 132.31 E-value: 7.25e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 79 LVVIFLEYFAWGLLtVPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLI--LTVLCTCMPIPC 156
Cdd:cd17325 2 SLALFLDMLGYGII-IPILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLlgLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 157 LKISPWWYFSLFSLSGLFS-VTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIV 235
Cdd:cd17325 80 FATSYWQLLLARFLQGLASaAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 236 SVADVIFIVLFVPESLPSRRNTGSvsqitpnevfnwQSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLK 315
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAV------------SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 316 LVVGFSPEAVAMYIGLVGILSVVAQTGFLHcLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMW-SAGVLAAMSSITY 394
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGK-LSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLlLLALLGLGLGLVF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 351064453 395 PSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLF 439
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
79-423 |
9.78e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.78 E-value: 9.78e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 79 LVVIFLEYFAWGLLTvPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCT--CMPIPC 156
Cdd:COG2814 16 ALGAFLSGLGIGIVL-PALPLIAADLGASPAQA-GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFalGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 157 LKISPWWYFSLFSLSGLFS-VTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIV 235
Cdd:COG2814 94 LAPSLWLLLAARFLQGLGAgALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 236 SVADVIFIVLFVPESLPSRRntgsvsqitpnevfnwqsADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLK 315
Cdd:COG2814 174 ALLALLLLLRLLPESRPAAR------------------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 316 LVVGFSPEAVAMYIGLVGILSVVAQTGFLHcLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMS-SITY 394
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGR-LADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLF 314
|
330 340
....*....|....*....|....*....
gi 351064453 395 PSISAFVSILSDKDKQGTVQGVITGIRGL 423
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
113-439 |
9.44e-26 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 108.85 E-value: 9.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWGRKAFLIL-TVLCTCMPIPCLKI-SPWWYFSLFSLSGLF-SVTFSVILAYVADIT 189
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAgLLLRALGFALLGFAhSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 190 DKSERSSAYGLVSATFAASLVTSPALGAYISEvYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRNTGSVSQitpnevf 269
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEI------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 270 nwqsadpFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGLVGILSVVAQTGFLHcLTS 349
Cdd:cd17329 190 -------LRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVAR-LVE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 350 RFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSITY-PSISAFVSILSDKDKQGTVQGVITGIRGLCTGFG 428
Cdd:cd17329 262 RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVfPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIG 341
|
330
....*....|.
gi 351064453 429 PALFGTVFYLF 439
Cdd:cd17329 342 PLVGGLLLDLL 352
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
79-429 |
1.19e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 105.19 E-value: 1.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 79 LVVIFLEYFAWGLLTVPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVL--CTCMPIPC 156
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEI-GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLlfALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 157 LKISPWWYFSLFSLSGLF-SVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIV 235
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 236 SVADVIFIVLFVPESLPSRRNTGSVSQITPNEVFNWQSADPFGSLRIVWedkLVLQLATIVFLSYLPesgqfscffvYLK 315
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL---LLFGFAFFGLLTYLP----------LYQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 316 LVVGFSPEAVAMYIGLVGILSVVAQtGFLHCLTSRFGTKHTITLGLIFQLI---QLTWYGLGTQYWMMWSAGVLAAMS-S 391
Cdd:pfam07690 228 EVLGLSALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfG 306
|
330 340 350
....*....|....*....|....*....|....*...
gi 351064453 392 ITYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGP 429
Cdd:pfam07690 307 LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
78-439 |
6.30e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 100.58 E-value: 6.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLTVPVINVLAETFPTNKFLmnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCM--PIP 155
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQL--GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALgaLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 156 CLKISPWWYFSLFSLSGLF-SVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSL--VVLLA 232
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGsGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWraVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 233 TIVSVADVIFIVLFVPESLPSRRNTGSVSQITPNevfnwqsadpFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFV 312
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASSKSV----------LKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 313 YLKLVVGFSPEAVAMYIGLVGILSVVAQTGFLHCLTSRFGTKHTITLGLIFQLIQLTWYGLG-TQYWMMWSAGVLAAMSS 391
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLApSLLLLLLLLLLLGFGLG 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 351064453 392 ITYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLF 439
Cdd:cd06174 309 GLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
111-441 |
1.38e-20 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 93.82 E-value: 1.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 111 MNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCLKI--SPWWYFsLFSLSGLFSVTFSVILAYVADI 188
Cdd:cd17331 36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFasSVPMLF-LSRLPSVFMHAMQAAQMVVTDL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 189 TDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPE-SLPSRRNTGSVSQITPNE 267
Cdd:cd17331 115 TDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSnTKSKREKEAKESASPPSV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 268 VFNWQsadpfgsLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGLVGILSVVAQTGFLHCL 347
Cdd:cd17331 195 FNLKE-------ILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 348 TSRFGTKHTITLGLIFQLIQLTWYGL-GTQYWMMWSAGVLAAMSSITYPSISAFVSILSDKDKQGTVQGVITGIRGLCTG 426
Cdd:cd17331 268 TKRFGERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRT 347
|
330
....*....|....*
gi 351064453 427 FGPALFGTVFYLFDV 441
Cdd:cd17331 348 VSPTIGGALLQAYGF 362
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
107-439 |
3.69e-18 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 86.56 E-value: 3.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 107 NKFLMNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLctcmpipCLKISP--WWY---FSLFSLS----GLFSVT 177
Cdd:cd17389 61 NSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMI-------GLAISYalWAVsrsFTIFLLSrivgGISKGN 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 178 FSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYIS------EVYGDSLVVLLATIVSVADVIFIVLFVPESL 251
Cdd:cd17389 134 VSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFAsftrslGEVFFSMPALFALVLALADLLFIFFFLPETL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 252 PSRRNtgsvsqitpnevfnwqsadpfgslRIVWEDKLVLQL-----ATIVFLSYlpESGQFScffvylklvvgfSPEAVA 326
Cdd:cd17389 214 PSNLR------------------------RLGLVYFLYLFLfsgleFTLTFLTH--QRFQYT------------SMQQGK 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 327 MYIgLVGILSVVAQTGFLHCLTSRfGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAM-SSITYPSISAFVSILS 405
Cdd:cd17389 256 MFF-FIGIIMALVQGGYVRRIKPG-KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYG 333
|
330 340 350
....*....|....*....|....*....|....
gi 351064453 406 DKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLF 439
Cdd:cd17389 334 SDDQKGTVMGIFRSLGALARALGPIVACTVYWLA 367
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
113-436 |
9.78e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 84.91 E-value: 9.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCLKISPWWYFSLFS--LSGLF-SVTFSVILAYVADIT 189
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLAraLAGLAhGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 190 DKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRntgsvsqitpnevf 269
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP-------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 270 nwQSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGLVGILSVVAQTGFLHcLTS 349
Cdd:cd17324 183 --GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR-LAD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 350 RFGTKhTITLGLIFQLIQLTWYGLGTQYWMMWSAG--VLAAMSSITYPSISAFVSILSDKDKqGTVQGVITGIRGLCTGF 427
Cdd:cd17324 260 RGGRR-ALLIALLLLAAALLLLTLLGPSPLLLLVGlvLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGAL 337
|
....*....
gi 351064453 428 GPALFGTVF 436
Cdd:cd17324 338 GAALGGLVL 346
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
80-379 |
2.16e-17 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 83.82 E-value: 2.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 80 VVIFLEYFAWGLLtVPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCLKI 159
Cdd:cd17390 3 LVGFLDLFGVSMI-LPLLSTHIRSLGASPTVI-GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 160 SPWWYFSLFS--LSGLFSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVY-GDSLVVLLATIVS 236
Cdd:cd17390 81 STSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDgGFYYVALLCSAIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 237 VADVIFIVLFVPEslpsrrntgsvsqitpnevfnwqsadpFGSLRIVwedKLVLQLATIVFlsylpesgqFSCFFVYLKL 316
Cdd:cd17390 161 ILNAGLVWFLLSK---------------------------LWDLLLV---RFLMGFSVLLF---------RSNFSLYLEE 201
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 351064453 317 VVGFSPEAVAMYIGLVGILSVVAQtGFLHCLTSRFGTKHTITLGLIF--QLIQLTWYGLGTQYWM 379
Cdd:cd17390 202 RFDLSPKTIGYLISYSGVLGALSG-FLVGRILKLYKNNEYLLLLHSFilLALSLLGLALAPSIWL 265
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
113-439 |
2.76e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 84.18 E-value: 2.76e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSD----VWGRKAFLIL-----TVLCTCM---PIPCLKISPWWYFSLFSLsgLFSVTFSV 180
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILigaipLALSFVLlftAPDLSPTGKLIYALVTYL--LLGLAYTL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 181 I----LAYVADIT-DKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDS------LVVLLATIVSVADVIFIVLFVPE 249
Cdd:COG2211 127 VnipySALGAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDaalgyrLTALIFAVLGLLAFLLTFFGTKE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 250 SLPSRRNTGSVSQitpnevfnwqsadpfgSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYI 329
Cdd:COG2211 207 RPVPEEEKVSLKE----------------SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 330 GLVGILSVVAQTGFLHcLTSRFGTKHTITLGLIFQ---LIQLTWYGLGTQYWMMWSAGVLAAMSSITYPSISAFVSILSD 406
Cdd:COG2211 271 ALYFLAALLGAPLWPR-LAKRFGKKKAFIIGLLLAalgLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVD 349
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 351064453 407 KDKQ-------GTVQGVITGIRGLCTGFGPALFGTVFYLF 439
Cdd:COG2211 350 YDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
78-436 |
3.32e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 80.70 E-value: 3.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLTVpVINVLAETF---PTNKFLMNGLVlgvkGLLSFLSAPLVGALSDVWG-RKAFLILTVLctcMP 153
Cdd:COG2223 10 ATLAFFLAFGVWYLWSV-LAPPLAEEFglsAAQLGLLFAIP----VLVGALLRIPLGFLVDRFGpRRVLLIGLLL---LG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 154 IPCL----KISPWWYFSLFSLSGLFS-VTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLV 228
Cdd:COG2223 82 IGLLllalAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 229 VLLATIVSVADVIFIVLFVPESLPSRRNTGSVSQITPNEVFnwqsadpfgSLRIVWedkLVLQLATIVFLSYLPESGQFS 308
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAL---------RDPRFW---LLSLLYFGTFGSFIGFSSWLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 309 cffVYLKLVVGFSPEAVAMYIGLVGILSVVAQTGFLHcLTSRFGTKHTITLGLIFQLIQLTW--YGLGTQYWMMWSAGVL 386
Cdd:COG2223 230 ---PYLVDQFGLSAATAGLLAALFALLGALGRPLGGW-LSDRIGGRRVLLIVFALMALGLLLlaLALGSLWLFLVLFLLL 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 351064453 387 AAMSSITYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVF 436
Cdd:COG2223 306 GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
113-441 |
9.25e-15 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 76.11 E-value: 9.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILT-------VLCTCMPIPCLKISPWWYFSLFSLSGLFSVTFSVIL-AY 184
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 185 VADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVAdVIFIVLFVPESLPSRRNTGSvsqit 264
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL-SALLLLFIRRPPPAAPGESS----- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 265 pnevfNWQSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGLVGILSVVAqTGFL 344
Cdd:cd06173 191 -----SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 345 HCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSITY-PSISAFVSILSDKDKQGTVQGVITGIRGL 423
Cdd:cd06173 265 GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSG 344
|
330
....*....|....*...
gi 351064453 424 CTGFGPALFGTVFYLFDV 441
Cdd:cd06173 345 AMPLGALLAGLLADALGL 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
78-247 |
9.56e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.08 E-value: 9.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLtVPVINVLAETFPTNKFLMNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCL 157
Cdd:cd17325 204 LFLAIFVLAFAFGAL-EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 158 KISP--WWYFSLFSLSGL-FSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATI 234
Cdd:cd17325 283 PLATsfWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
|
170
....*....|...
gi 351064453 235 VSVADVIFIVLFV 247
Cdd:cd17325 363 LLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
74-435 |
1.87e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 75.28 E-value: 1.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 74 SVSHALVVIFLEYFAWGLLT---VPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCT 150
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATalwGPLIPALKDAFGLSDAQA-GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 151 CMPIPCLKISPWWYF---SLFSLSGLFSVTFSVILAYVADITDKSeRSSAYGLVSATFAASLVTSPALGAYISEVYGDSL 227
Cdd:COG0738 84 ALGLLLFALAPSYPLlllALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 228 VVLLATIVSVADVIFIVLFVPESLPSRRNTGSvsqitpnevfnwQSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQF 307
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEE------------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 308 SCFFVYLKLVVGFSPEAVAMYIGLVGILSVVAQ--TGFlhcLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWM-MWSAG 384
Cdd:COG0738 231 DWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRflGGF---LLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLaLIGLA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 351064453 385 VLAAMSSITYPSISAFVSILSDKDKQGTVqGVITGIRGLCTGFGPALFGTV 435
Cdd:COG0738 308 LVGLGLSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFL 357
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
79-436 |
5.40e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 73.40 E-value: 5.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 79 LVVIFLEYFAWGLLtVPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLI--LTVLCTCMPIPC 156
Cdd:cd17489 2 LLANFFFFLSFYLL-LPVLPLYAHDLGGSEAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLigLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 157 LKISPWWYFSLFSLSGL-FSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIV 235
Cdd:cd17489 80 LATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 236 SVAdVIFIVLFVPESLPSRRNTGSVSQITPNEVFNwqsadpfgslrivwedKLVLQLATIVFLSYLPESGQFScfFVYLK 315
Cdd:cd17489 160 ALL-ALLLVFLVKDPPPVAAEEAEAGTRAFRRLVE----------------KKVLPPALILFLASIAYGAIST--FLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 316 LVVGFSPEAvAMYIGLVGILSVVAQTgFLHCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWM-MWSAGVLAAMSSITY 394
Cdd:cd17489 221 AAERGISNA-GLFFTVYAIALLLSRP-FSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMlLLAAVLYGLGFGLLF 298
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 351064453 395 PSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVF 436
Cdd:cd17489 299 PALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
92-440 |
1.70e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 72.22 E-value: 1.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 92 LTVPVINVLAETFPTNKFlMNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLIltvlctcmpiPCLKIspwwyFSLFSLS 171
Cdd:cd17474 17 IVDPILPAIAEALGASPA-QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLL----------PGLLL-----FGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 172 GLFSVTFSVILAY------------------VADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLAT 233
Cdd:cd17474 81 CGLSDSFALLLAGralqgigaaglgplaltlIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 234 IVSVAdVIFIVLFVPESLPSRRNTgsvsqitpnevfnwqSADPFGSLRIVWEDKLVLQLATIVFLSYLpesgQFSCFFVY 313
Cdd:cd17474 161 LIPVA-FLAILFLLPEPKEKAKSS---------------SATKLRDLKKALRGRGLLTFLVSAFLYFF----LYFAFLTY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 314 LKLVVGFSPEAVAMYIGLV----GILSVVAQTGFLHCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAM 389
Cdd:cd17474 221 LPFLLELLYGISPIIIGLLfagwSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGL 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 351064453 390 SS-ITYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLFD 440
Cdd:cd17474 301 GLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
78-436 |
1.28e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 69.13 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLTVpVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCT--CMPIP 155
Cdd:COG2271 15 LFLAYFLNYLDRSNLSV-AAPPLQADLGLSAAQL-GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWglATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 156 CLKISPWWYFSLFSLSGLF-SVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATI 234
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 235 VSVADVIFIVLFvpeslpsrrntgsvsqitpnevfnwqsadpfgslrivwedklvlqLATIVFLSYLPESGQFSCFFVYL 314
Cdd:COG2271 173 PGLLLALLRFWL---------------------------------------------LALAYFLVYFALYGFLTWLPTYL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 315 KLVVGFSPEAVAMYIGLVGILSVVAQTGFLHcLTSRFGTKHTITLGLIFQLIQLTWYGL---GTQYWMMWSAGVLAAMSS 391
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGW-LSDRLGRRRKLVLAIGLLLAALALLLLallPSPALAIALLFLAGFGLG 286
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 351064453 392 ITYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVF 436
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
81-436 |
2.73e-12 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 68.46 E-value: 2.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 81 VIFLEYFAWGLLTVPVINVLAetfpTNKFLMNGLVLGvkGLLSFLSAPLVGALSDVWGRKAFLILTVL-----CTCMPIP 155
Cdd:cd17386 7 IVFLYMFASVLSGPVTQNFVY----AANFYLYMNLMG--SIPPLFSSLFLGSWSDRYGRKPPLLMSLVglllsSLILVLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 156 CL---KISPWWYFS---LFSLSGLFSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVV 229
Cdd:cd17386 81 VYfttVPSVWWFYLsaiPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 230 LLATIVSVADVIFIVLFVpeslpsrrntgsvsqitpnevfnwqsadpfgslrivwedKLVLQLATIVFLSYLPESGQFSC 309
Cdd:cd17386 161 SISAALLLIALLYILFFL---------------------------------------TLLILLLLAAFLTIFVLSGESDV 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 310 FFVYLKL-----VVGFSP-EAVAMYIGLVGILSVVAqtgFLHCLTsRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSA 383
Cdd:cd17386 202 LYLFVLEkfawnVKDFSYfSTLGSLIYLTGMLGGVL---LLRCLL-KMSDSTLAMLGLASHILSSLLFAFATNTWMMYLA 277
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 351064453 384 GVLAAMSSITYPSISAFVSILSDKDKQGTVQGVItgirGLCTGFGPALFGTVF 436
Cdd:cd17386 278 AVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLL----SVLESLSPLVASPIY 326
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
129-439 |
1.40e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 62.98 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 129 LVGALSDVWGRK--------AFLILTVLCTCMPipclkiSPWWYFSLFSLSGLFSVTFSVI-LAYVADITDKSERSSAYG 199
Cdd:cd17320 53 LYGPLSDRFGRRpvllagllLFILASLLCALAS------SIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 200 LVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRNTGSVSQItpnevfnwqsadpFGS 279
Cdd:cd17320 127 LLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSL-------------LRA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 280 LRIVWEDK------LVLQLATIVFLSYLPESGqfscfFVYLKlVVGFSPEAVAMYIGLVGILSVVAqTGFLHCLTSRFGT 353
Cdd:cd17320 194 YKRVLKNRrflgyaLALGLSFAGLFAYLAAAP-----FIYIE-QLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGP 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 354 KHTITLGLIFQ------LIQLTWYGLGTQYWMMWSAGVLAAMSSITYPSISAFVSILSDKDK------QGTVQGVITGIR 421
Cdd:cd17320 267 RRLLRLGLLLLlaaalvLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAgtasalLGFLQFLIGALA 346
|
330
....*....|....*...
gi 351064453 422 GLCTGFGPALFGTVFYLF 439
Cdd:cd17320 347 GALVGLLPNGTALPMGLL 364
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
113-433 |
1.79e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 62.67 E-value: 1.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWGrkAFLILTVLCTCMPIPCLKI----SPWWYFSLFSLSGLF--SVTFSVILAYVA 186
Cdd:cd17355 41 SLAFTVGLLAFGLAQPFVGRLLDRFG--PRRVMLLGLLLLAAGLVLLalatSLWQLYLLWGLLGGGgaGTLAAVAFATVA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 187 DITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVAdVIFIVLFVPESLPSRRNTGSVSQITPn 266
Cdd:cd17355 119 AWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALL-VLVPVLLLLRRRPADLALRAYDDASP- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 267 evfnwqsADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLvVGFSPEAVAMYIGLVGILSVVAQTGFLHc 346
Cdd:cd17355 197 -------ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGW- 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 347 LTSRFGTKHTITLGLIFQLIQLTWYGLGT-QYWMMWSAGVLAAMSSITY-PSISAFVSILSDKDKQGTVQGVITGIRGLC 424
Cdd:cd17355 268 LGDRYSPRRLLAASYALRALGLALLLLLPfPPLALLLFAALFGLGWGATvPLTAALAARYFGARSYGTLFGLVFAPHQLG 347
|
....*....
gi 351064453 425 TGFGPALFG 433
Cdd:cd17355 348 SALGPWLGG 356
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
92-417 |
2.94e-10 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 62.23 E-value: 2.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 92 LTVPVINVLAETFPTNKFLMNGLVLGVKGLL-SFLSAPLvGALSDVWGRKA--------FLILTVLCTcmpipcLKISPW 162
Cdd:cd17472 14 LVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPvilfglllFIAGSLLAA------YATSIY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 163 WYFSLFSLSGLFSVTfSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIF 242
Cdd:cd17472 87 GLILGRALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 243 IVLFVPESLPSRRNTGSVSQITPNEVFNWqsadpfgslrivwedklvlQLATIVFLSYLPESGQFSCFFV---YLKLVVG 319
Cdd:cd17472 166 LLFFVPDPPKIVQISEKEKKKLKKLLKNK-------------------RLLRLDFSIFILHFVLMAFFYIlplLLTQLGG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 320 FSPE-------AVAMYIGLVGILSVVAQTgflhcltsRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMS-- 390
Cdd:cd17472 227 GKGQlwkvylpAILIGFILMVPFVIYAEK--------KGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIgf 298
|
330 340
....*....|....*....|....*..
gi 351064453 391 SITYPSISAFVSILSDKDKQGTVQGVI 417
Cdd:cd17472 299 NLLEALLPSLVSKIAPKEYRGTAMGIY 325
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
113-440 |
7.62e-10 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 60.94 E-value: 7.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWGRK-----AFLILTVLCTCMpIPCLKISPWWYFSLFSLSGLFSVTFSVIL--AYV 185
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKkpflaFFTLLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 186 ADITDKSE--RSSAYG--------LVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESlPSRR 255
Cdd:COG2270 134 PDIATPEEigRVSGLGwalgylggVLLLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPER-PRPG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 256 NTGSVSQITpnEVFnwqsADPFGSLRIVWEDKLVLQ-----------LATIVFLSylpesgqfscfFVYLKLVVGFSPEA 324
Cdd:COG2270 213 PAPPRGAVR--AGF----RELRRTLRELRRYRDLLRfllayffyrdgVQTVIAFA-----------GIYAAGVLGFSTTE 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 325 VAMYIGLVGILSVVAQTGFLHcLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSITYPSIS-AFVSI 403
Cdd:COG2270 276 LIVFGLLVQIVAALGALLFGR-LDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLAR 354
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 351064453 404 LSDKDKQG------TVQGVITGIrglctgFGPALFGTVFYLFD 440
Cdd:COG2270 355 LIPPGREAeffglyALSGKAASF------LGPLLFGLVTQLTG 391
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
90-418 |
1.30e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.28 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 90 GLLTVPVINVLAETFPTNKFLMNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLctcmpipclkispwwYFSLFS 169
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLL---------------LYGIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 170 LSGLFSVTFSVILAY------------------VADITDKSERSSAYGLVSATFAASLVTSPALGAYISE--------VY 223
Cdd:cd17473 80 VAGLFLDSLYALLASrallgigvagimtlatalIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEigwrapflVY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 224 GDSLVVLlativsvadvIFIVLFVPEslPSRRNTGSVSQITpnevfnwQSADPFGSLRIVWedklvlqLATIVFLSYLpe 303
Cdd:cd17473 160 LLALPVL----------ILVLLFLPE--PARKSKSAASPGA-------ATAAALPWKRVLP-------IYFLAFLAML-- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 304 sgQFSCFFVYLKLVV----GFSPEAVAMYIGLVGILSVVAQTGFLHcLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWM 379
Cdd:cd17473 212 --LFYVIPIQLPFLLqergGGSAALIGLALAIASLAGAIGALLFGR-LKRRLGKRRLLAIGFALMALGFLLLALASGLWV 288
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 351064453 380 MWSAGVLAAM-SSITYPSISAFVSILSDKDKQGTVQGVIT 418
Cdd:cd17473 289 VLLGAILAGLgFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
113-437 |
1.66e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 1.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWG-RKAFLILTVLCTCM---PIPCLKISPWWYFSLFSLSGLFS---VTF--SVILA 183
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLfflSLFFVAQIFWLLLLLVILGAFFSapvVPLvdSITLQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 184 YVADITDKserssaYGLV----SATFAAslvTSPALGAYI--SEVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRnt 257
Cdd:cd17335 115 YLGEERER------YGKQrlwgSIGFGI---AALLVGILIdrSSTYKNYTIAFYVFAVLMLLALLLALKFPFRPKHPE-- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 258 gsvsqitpnevfnwqSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLvVGFSPeavaMYIGLVGILSV 337
Cdd:cd17335 184 ---------------PNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQD-LGGSK----TLIGLLWTVGV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 338 VAQTG---FLHCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMS-SITYPSISAFVSILSDKDKQGTV 413
Cdd:cd17335 244 VSEIPfffFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTfALVWAAAVSYASAAAPPGLRATA 323
|
330 340
....*....|....*....|....*
gi 351064453 414 QGVITGIR-GLCTGFGpALFGTVFY 437
Cdd:cd17335 324 QGLLQGLYfGLGGGLG-SLIGGYLY 347
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
114-244 |
5.14e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 58.32 E-value: 5.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 114 LVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCmpIPCL----KISPWWYFSLFSLSGLF-SVTFSVILAYVADI 188
Cdd:cd17370 238 LLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLA--LAYLgfalGSSLWLLLLGFILWGLYmGAQESIERAAVADL 315
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 351064453 189 TDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIV 244
Cdd:cd17370 316 VPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
78-249 |
2.77e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.03 E-value: 2.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLTVPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCL 157
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA-GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 158 KI----SPWWYFSLFSLSGLFS-VTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLA 232
Cdd:COG2271 264 LLallpSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLL 343
|
170
....*....|....*..
gi 351064453 233 TIVSVADVIFIVLFVPE 249
Cdd:COG2271 344 AALALLAALLALLLLRE 360
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
78-344 |
5.66e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 54.43 E-value: 5.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLTVpVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLIL--------TVLC 149
Cdd:COG0477 19 LALGTFLEGLDFTIVNV-ALPSIAADLGASSAQL-GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIglllfglaSLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 150 TCMPipclkiSPWWYFSLFSLSGLF-SVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLV 228
Cdd:COG0477 97 GLAP------SPELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 229 VLLATIVSVAdVIFIVLFVPESlpsrRNTGSVSQITPNEVFNWQSADPFGSLRIVWEDKLVLQLATIVFLSYLPESGQFS 308
Cdd:COG0477 171 FLINAPLGLL-ALVLRLRLPES----RGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260 270
....*....|....*....|....*....|....*.
gi 351064453 309 CFFVYLKLVVGFSPEAVAMYIGLVGILSVVAQTGFL 344
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLL 281
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
113-435 |
1.10e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 54.19 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCLKISP--WWYFSLFSLSGLFSVTFSVILAYVADITD 190
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTnvWQLLILRLLQGVFSGYVPNATALIASQTP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 191 KSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPES-LPSRRNTgsvsQITPNEVf 269
Cdd:cd17391 119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDfKPVEKKK----MVSTKEV- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 270 nWQSADPFGSLRIVWEDKLVLQLATIVFLSYLPesgqfscffVYLKLVVGFSPEaVAMYIGLV----GILSVVAqTGFLH 345
Cdd:cd17391 194 -WNSVPNPSLLISLFVTTFIIQLANQSIEPILT---------LYIRQLMGDASN-LAFISGLVfsatGVSSLLS-APRLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 346 CLTSRFGTKHTITLGLIF--------QLIQLTWYGLGTQYWMMWSAGVLAamssityPSISAFVSILSDKDKQGTVQGVI 417
Cdd:cd17391 262 KLGDRIGHHRILLGALLAsallyipqAFVQTPWQLGILRFLLGLATGGLL-------PAINSLLAKITPKEVAGRIFGYN 334
|
330
....*....|....*...
gi 351064453 418 TGIRGLCTGFGPALFGTV 435
Cdd:cd17391 335 QSFQYLGNVAGPLLGSAI 352
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
128-439 |
3.20e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.56 E-value: 3.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 128 PLVGALSDVWGRK--------AFLILTVLCTCMPipclkiSPWWYFSLFSLSGLF-SVTFSVILAYVADITDKSERSSAY 198
Cdd:cd17321 49 LLAGRLGDRFGRKrvfliglaLFGLASLLCALAP------SLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRAL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 199 GLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFvpeslpsrrntgSVSQITPnevfnwqsadpfg 278
Cdd:cd17321 123 GLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTF------------SGAVLAA------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 279 slrivwedkLVLQLATIVFLSYLPesgqfscffVYLKLVVGFSPEAVAMYIGLVGILSVVAqTGFLHCLTSRFGTKHTIT 358
Cdd:cd17321 178 ---------FLLGAALGGLLFLLP---------LYLQGVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 359 LGLIFQ---LIQLTWYGLGTQYW-MMWSAGVLAAMSSITYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGT 434
Cdd:cd17321 239 AGLLLTavgLLLLALLGADSSVWlLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGA 318
|
....*
gi 351064453 435 VFYLF 439
Cdd:cd17321 319 LLTAG 323
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
110-455 |
7.88e-07 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 51.54 E-value: 7.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 110 LMNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPclkispwwYFSLFSLSglfSVTFSVILayvaDIT 189
Cdd:pfam13347 72 LLSAIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIP--------YWSLGPEL---TRDYDERT----SLT 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 190 DKSERSSAYGLVSATFAASLVTSPaLGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRNtgsvsqiTPNEVF 269
Cdd:pfam13347 137 SYRSFFSVGGGLLAAALAFPLVLI-LGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSK-------EDTGQK 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 270 NWQSAdpFGSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFspEAVAMYIGLVGILSVVAQTGFLHCLTS 349
Cdd:pfam13347 209 EAGSL--LDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGN--GFAASAFPLVFTIGALLGIPLWPPLAK 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 350 RFGTKHTITLGLIFQLIqltwyGLGTQYWM----MWSAGVLAAMSSITYPSI-SAFVSILSDKDKQGTVQ------GVIT 418
Cdd:pfam13347 285 RIGKKNTYILGALITIA-----GFALALLLgpnnTLLFLVLYIIIGFGYGSSfFLPWSMLADVVDYGELRtgkrreGTFF 359
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 351064453 419 GIRGLC----TGFGPALFGTVFYLFDVDLEDEKSTGGALSL 455
Cdd:pfam13347 360 AMWSFIsklaTGVGLGVSGLLLSAFGYNAGDSVQSPQAVTA 400
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
113-257 |
1.13e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.03 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWGRK-----AFLILTVLCTCMPIPclKISPWWYFSLFSLSGLF-SVTFSVILAYVA 186
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRrvlliVFALMALGLLLLALA--LGSLWLFLVLFLLLGLAlGGGNGAVFALVP 321
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351064453 187 DITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRNT 257
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
113-431 |
2.26e-06 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 49.94 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWG-RKAFLILTVLC-TCMPIPCLKISP----WWYFSLFSLSGLFSVTfSVILAYVA 186
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILaAVLFLSVLFIPIsltfWWLALLVVLFSFFWNA-ILPQFEVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 187 DITDKSERSSAYGLV----SATFAaslVTSPALGAYISEVYGDSLVVLLAtivsvadVIFIVLFVpeslpsrrntgsVSQ 262
Cdd:pfam12832 116 TLQHLGEKRKDYGRQrlwgSVGFA---LSVFGLGALFDHYSVGLLPSVLF-------YLFAALML------------LSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 263 ITPNEVFNWQSADPFGSLRIVWE---DKLVLQLATIVFLSYLPESGQFSCFFVYLKlVVGFSPEAVAMYIGlVGILSVVA 339
Cdd:pfam12832 174 LLPLAPPEMEYESKGGSKAVFWNllkQPEVIIFFLAAFLLGFSHGPFYTFLFLYLE-NLGASNTLLGALWA-LGVVAEIP 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 340 QTGFLHCLTSRFGtkHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSITYPSISA----FVSILSDKDKQGTVQG 415
Cdd:pfam12832 252 LFFYAHRLLRRFG--HRNLLIIALLLTALRWLLYAFFVENPWLVLPIQFLHAISFGLTHAaaieYVRRIFPGSLQGTGQA 329
|
330
....*....|....*.
gi 351064453 416 VITGIrglCTGFGPAL 431
Cdd:pfam12832 330 LYSGL---YFGLGGAL 342
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
95-362 |
4.65e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.09 E-value: 4.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 95 PVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCLKISP--WWYFSLFSLSG 172
Cdd:cd17478 17 ALLPLLIAKLGLSYAQA-GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPnyWLLLLLVALAG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 173 LFSVTFSVILAYVADITDKSERSSAYGLVSA--TFAASLvtSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPES 250
Cdd:cd17478 96 IGSAAFHPEGARLASQAAGGRRGLAMSIFSVggNLGFAL--GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 251 LPSRRNTGSVSQITPNEVFNWqsadpfgslrivwedKLVLQLATIVFLSYLPESGqFSCFFVYLKLVVGFSPEAVAMYIG 330
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVW---------------RALLLLLIIVFLRSWVLSS-LTTFLPFYLVQRGYSLVFAGLLLS 237
|
250 260 270
....*....|....*....|....*....|..
gi 351064453 331 LVGILSVVAQTGFLHcLTSRFGTKHTITLGLI 362
Cdd:cd17478 238 LFLFAGAIGTLIGGP-LSDRFGRRRVIIASLL 268
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
94-445 |
5.17e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 48.73 E-value: 5.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 94 VPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCLKISPWWYFSLFS--LS 171
Cdd:cd17504 16 SPALPTIQREFGTSAAAV-SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGraLQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 172 GLFSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVAdVIFIVLFVPESL 251
Cdd:cd17504 95 GIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL-LAALVPLIDLRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 252 PSRRNTGSVSQITpnevfnwqsadpfgslrivwedkLVLQLAT---IVFLSYLPESGQFSCFfvylklvvGFSPEAVAMY 328
Cdd:cd17504 174 LRRRNVLLANITA-----------------------LLAGFGMfmvFQLLPQLLQLPTPTGF--------GLGITEAGLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 329 IGLVGILSVVAQ--TGFlhcLTSRFGTKHTITLGLIFQLI--QLTWYGLGTQYWMMWSAGVLAAMSSITYPSISAFVSIL 404
Cdd:cd17504 223 LLPGALVMLIAGplAGR---LIARVGPRRVLLIGLVISAVglLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVES 299
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 351064453 405 SDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLFDVDLED 445
Cdd:cd17504 300 VPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITS 340
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
78-246 |
8.73e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.98 E-value: 8.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLTVPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILT-VLCTCMPIPC 156
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATS-SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGlILSGILALPL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 157 LKI---SPWWYFSLFSLSGLFSVTFSVIL-AYVADITDKSERSSAYGLVSAT-FAASLVTSPALGAYISEVYGDSLVVLL 231
Cdd:cd17316 261 FYLlsgSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLgRLGGGGAPPLIALLLASTGGTGVPALI 340
|
170
....*....|....*
gi 351064453 232 ATIVSVadVIFIVLF 246
Cdd:cd17316 341 LALLAI--VALIVAL 353
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
113-243 |
1.41e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCT---CMPIPCLKISPWWYFSLFSLSGLFSVT-FSVILAYVADI 188
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGalaALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDR 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 351064453 189 TDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFI 243
Cdd:cd17477 306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
113-433 |
1.84e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 47.21 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSD-------------VWGRKAFLILTVLCTCMPIPCLKISPWWYFSLFSLSGLFSVTFS 179
Cdd:cd17332 38 GTIFLVARIIDAINDPLMGYLIDrtrsrwgrfrpwlLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 180 V-ILAYVADIT-DKSERS--SAYGLVSATFAASLVTS--PALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESlpS 253
Cdd:cd17332 118 IpYTALIPELTdDPEERTslTSWRMFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT--R 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 254 RRNTGSVSQITPNEVFNwqsadpfgSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGLVG 333
Cdd:cd17332 196 ERVVPPEEEKSKLPLLK--------SLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 334 ILSVVAQTGFLhcLTSRFGTKHTITLGLIFQLIQLTWYGLGtQYWMMWSAGVLAAMSSITYPSISAFV-SILSD------ 406
Cdd:cd17332 268 GALLALLPWPP--LKKRFGKKKAFFIGLLLAILGLLLLFFL-PPGNLVLILVLAVLAGIGYGGANLLPwAMLADvidyge 344
|
330 340 350
....*....|....*....|....*....|.
gi 351064453 407 ----KDKQGTVQGVITGIRGLCTGFGPALFG 433
Cdd:cd17332 345 lktgKRREGIFYSVMTFFRKLGLALAGALVG 375
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
106-437 |
2.14e-05 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 46.82 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 106 TNKFLmnGLVLGVKGLLSFLSAPLVGALSDVwGRKAFLILTVLCTCMPIPCL------KISPWW-YFSLFS--LSGLFSV 176
Cdd:cd17326 34 TASFF--GWVVAAYSLGQLVFSPVFGYWSNK-TSSVKEPLIVSILIAIVGNIlyalaeYFPSNRkYVMLVArfLIGVGAG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 177 TFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGA------YISEVYGDSLVV-------LLATIVSVADVIFI 243
Cdd:cd17326 111 NVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAaftpigYPGYVIGIKLRFnmytapaWLMAILGIINIILI 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 244 VLFVPESlpsrrntgsvsqitpnevfnwqsadpfgslrIVWEDKLVLQLATIVFLSYLPesgqfscffVYLKLVVGFSPE 323
Cdd:cd17326 191 LFFFKEV-------------------------------VCIFLFFVVLFIFANLETIGT---------PLTMDMYGWTRE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 324 ----AVAMYIGLVGILSVVAQTGFLHCLTSRFGTKHTITLGLIFQLIQLTWYglgTQYWMMWSAGVLAAMSSITYPSISA 399
Cdd:cd17326 231 eavlYNGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT---LPWGITGVILFGLGYPIGNVMLYTL 307
|
330 340 350
....*....|....*....|....*....|....*...
gi 351064453 400 FVSILSDKDkQGTVQGVITGIRGLCTGFGPaLFGTVFY 437
Cdd:cd17326 308 YSKILGPKP-QGTMQGVLTASGSLARTLGP-IFVTAIY 343
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
129-405 |
3.01e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.39 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 129 LVGALSDVWG-RKAFLILTVLC---TCMPIPCLKiSPWWYFSL-FSLSGLFSVTFSVILAYVADITDKSERSSAYGLVS- 202
Cdd:cd17471 51 WLGRLSDRGGdRKPLILLALLAgalGYLLFAFLR-NYWVLLLVgVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNSv 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 203 --ATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVAdVIFIVLFVPESLPSRRNTGSVSQITPNEVFNWQSADPFGSL 280
Cdd:cd17471 130 lrAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLV-VALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAF 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 281 rivwedkLVLQLATIVFLSYLPesgqfscffVYLKLVVGFSPEAVAMYIGLVGILSVVAQTGFLHcLTSRFGTKHTITLG 360
Cdd:cd17471 209 -------TLLFAANSMYIIAMP---------LYVTNELGGSESWVGLLFGLAAALEIPIMLLAGL-LAKRFGKRRLLLAG 271
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 351064453 361 LIFQLIQLTWYGLGTQYWMMWSAGVLAAmssitypsisAFVSILS 405
Cdd:cd17471 272 FLAGVLFYLGLALATSLWQLIALQLLNA----------IFIGITA 306
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
113-436 |
5.62e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 45.63 E-value: 5.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWG--RKAFLILTVLCTCMPIPCLKISPWWYFSLFSLSGL-FSVTFSVILAYVADIT 189
Cdd:COG2807 56 GLLTTLPLLAFGLFAPLAPRLARRFGleRTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAgIAVGNVLLPGLIKRWF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 190 DKsERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRNTGSVSqitpnevf 269
Cdd:COG2807 136 PD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA-------- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 270 nwqsadpfgSLRIVWEDKLVLQLATIVFLSylpeSGQFSCFFVYLKLVV---GFSPEAVAMYIGLVGILSVVAQTgFLHC 346
Cdd:COG2807 207 ---------SLRSLWRSPLAWLLTLFFGLQ----SLLYYAVVAWLPPILrdaGLSAATAGLLLSLFQLAGIPGSL-LVPL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 347 LTSRFGTKHTI-TLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSITYPSISAFVSILSDKDKQ-GTVQGVITGIRGLC 424
Cdd:COG2807 273 LADRLGDRRPLlLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLL 352
|
330
....*....|..
gi 351064453 425 TGFGPALFGTVF 436
Cdd:COG2807 353 AALGPLLVGALH 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
78-395 |
7.51e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 7.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 78 ALVVIFLEYFAWGLLTvPVINVLAET--FPTnkfLMNGLVLGVKGLLSFLSAPLVGALSDVWG-RKAFLILTVLCTCMPI 154
Cdd:cd17477 1 LLLSVALLGLGSGLLL-PLLSLRLERegVST---ALIGLVASAYYLGILLGSPLVPRLIRRVGhIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 155 PC-LKISPWWYFSLFSLSGLFSVTFSVIL-AYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISeVYGDSLVVLLA 232
Cdd:cd17477 77 LLaLTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 233 TIVSVAdvIFIVLFVPESLPSRRNTGSvsqitpnevfnwqsadpfGSLRIVWedKLVLQLATIVFLSYLPESGQFSCFFV 312
Cdd:cd17477 156 VLLLLA--LVPLLLTRRAAPEIEEAES------------------ISLRRLL--RIAPLALLGAFVAGFLEGAFYSLLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 313 YLkLVVGFSPEAVAMYIGLVGILSVVAQTgFLHCLTSRFGTKHTITL-GLIFQLIQLTWYGLGTQYWMMW-SAGVLAAMS 390
Cdd:cd17477 214 YG-LRLGLSVAQAALLLAAFVLGGLLLQW-PLGWLADRFDRRRVLLGcALLGALAALLLPLVPGLPLALLvLLFLWGGAA 291
|
....*
gi 351064453 391 SITYP 395
Cdd:cd17477 292 GPLYT 296
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
113-433 |
7.72e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 7.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWG-RKAFLILT-VLCTCM-PIPCLKISPWWYFSLFSL----SGLFSvtfSVILAYV 185
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGyGLSALAkPLLALAGSWQLVLLLRILerlgKGIRT---PPRDALL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 186 ADITDKSERSSAYGLVSA--TFAAslVTSPALGAYISEVYGDS--LVVLLATIVSVADVIFIVLFVPESLPSRRNTGSVS 261
Cdd:cd17370 114 ADATPPSGRGKAFGLHRAldTLGA--VLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 262 qitpnevfnWQSADPFGslRIVWedkLVLQLATIVFLSYLPESgqfscFFVYLKLVVGFSPEAVAMYIGLVGILSVVAQT 341
Cdd:cd17370 192 ---------KTSLKKLP--KAFW---LYLLAVALFALGNFSFA-----FLILRAQELGLSAALIPLLYALFNLVYALAAY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 342 --GFLHcltSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMS-SITYPSISAFVSILSDKDKQGTVQGVIT 418
Cdd:cd17370 253 paGRLS---DRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFN 329
|
330
....*....|....*
gi 351064453 419 GIRGLCTGFGPALFG 433
Cdd:cd17370 330 TVVGIGWLLASLIAG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
292-439 |
1.15e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.33 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 292 LATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGLVGILSVVAQTgFLHCLTSRFGTKHTITLGLIFQLIQLTWY 371
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQP-LAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 351064453 372 GLGTQYWMMWSAGVLAAM-SSITYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLF 439
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
95-249 |
4.97e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.56 E-value: 4.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 95 PVINVLAETFPTNKFLMNgLVLGVKgLLSFLSAPLVGA-LSDVWGRKAFLILT-VLCTCMPIPC-LKISPWWYFSLFSLS 171
Cdd:cd17323 20 PALPQIAEDFHVSEEVAN-LGVSLF-VLGFGLGPLIWApLSELYGRRPVYLVSlFIFVIFQIGCaLAPNIAMLIILRFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 172 GLFSVTF-SVILAYVADITDKSERSSAYGLVS-ATFAASLVtSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPE 249
Cdd:cd17323 98 GFFGSSPlAIGAGTIADLFTPEERGKAMGVYSlGPLLGPAL-GPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPI 176
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
124-250 |
7.70e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 42.31 E-value: 7.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 124 FLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCLKISP--WWYFSLFSLSGLFSVTFSVI-LAYVADITDKSERSSAYGL 200
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPnyTVFLVFRLLVGMGIGGIWVQaVVLNTEFLPKKQRAIVGTL 220
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 351064453 201 VSATFAASLVTSPALGAYISEVYGDSLVvllatiVSVADVIFIVL--FVPES 250
Cdd:TIGR00898 221 IQVFFSLGLVLLPLVAYFIPDWRWLQLA------VSLPTFLFFLLswFVPES 266
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
83-435 |
9.98e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.43 E-value: 9.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 83 FLEYFAWGLLTVpVINVLAETFPTN-KFLMNGLVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTVLCTCMPIPCLKISP 161
Cdd:cd17316 9 FFDAYDFFLIGF-VAPVLAAEFSLGlSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 162 --WWYFSLFSLSGLF-SVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSL---VVLLATIV 235
Cdd:cd17316 88 tpILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwrILFLIGAL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 236 SVadviFIVLFVpeslpsRRNTgsvsqitpnevfnwqsadpfgslrivwedklvLQLATIVFLSYLPESGQFSCFFVYLK 315
Cdd:cd17316 168 PA----LLALLL------RRRT--------------------------------LLLILLWFFISFGYYGLTTFLPTYLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 316 LVVGFSPEAVAMYIGLVGILSVVAQTGFLHcLTSRFGTKHTITLGLIFQLIQLTWYGLGTQ---YWMMWSAGVLAAMSSI 392
Cdd:cd17316 206 TVLGLSPATSSLYLLLISLGALVGALIAGL-LSDRIGRKKTLVIGLILSGILALPLFYLLSgspTLLLLLLFILSFFVGG 284
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 351064453 393 TYPSISAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTV 435
Cdd:cd17316 285 VWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
114-246 |
1.26e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.44 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 114 LVLGVKGLLSFLSAPLVGALSDVWGRK-----AFLILTVLCTCMPIpcLKISPWWYFSLFSLSGL-FSVTFSVILAYVAD 187
Cdd:cd17353 253 LAVSILSIFNGGGRPFWGWLSDKIGRKntlsiAFLIQGVAMFLLPF--IGSVAVLFVLGVALIGFcYGGGFALFPALTAD 330
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 351064453 188 ITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLF 246
Cdd:cd17353 331 FFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
319-440 |
1.46e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.11 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 319 GFSPEAVAMYIGLVGILSVVAQTgFLHCLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAM-SSITYPSI 397
Cdd:COG2814 41 GASPAQAGLVVTAYLLGAALGAP-LAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLgAGALFPAA 119
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 351064453 398 SAFVSILSDKDKQGTVQGVITGIRGLCTGFGPALFGTVFYLFD 440
Cdd:COG2814 120 LALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
113-363 |
1.55e-03 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 40.95 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSaPLVGALSDVWGRKAF----------LILTVLCTCMPIPCLKIS-----PWWYFSL--FSLSGL-F 174
Cdd:cd06176 39 GLLIALHYLVAPLR-VWIGHRSDTHPLRGYrrtpyiwlgmLLLALGLALAPFAALLLAgaafwLGLALAVlaFLLYGIgV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 175 SVTFSVILAYVADITDKSERSSAYGLV-SATFAASLVTSPALGAYIsEVYGDSLVVLLATIVSVADVIFIVLFVPESLPS 253
Cdd:cd06176 118 GAAGTAFLALLADLTPEERRPRAVTVVwTMLILGIIVTAIVFGRLL-DPYSPERLIQVFQIVALVALLLALLALWGVERR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 254 RRNTGSVSQITPNEVFnWQsadpfgSLRIVWEDKLVLQLATIVFLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGL-- 331
Cdd:cd06176 197 RSRAALAAEEAPPETF-RE------ALRLLWASPQARRFFIFLFLSTLALFMQDVILEPFGGEVFGMSVGETTRLTAIwg 269
|
250 260 270
....*....|....*....|....*....|..
gi 351064453 332 VGILSVVAQTGFLhcLTSRFGTKHTITLGLIF 363
Cdd:cd06176 270 GGTLLGMLLAGFL--LSRRLGKKRTAALGCLL 299
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
142-247 |
2.22e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 142 FLILTVlcTCMPIPCLKiSPWWYFSLFSLSGL-FSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYIS 220
Cdd:cd17490 268 FLLLGA--YCFLIPFAP-NLTLLYLLQALNGFgTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIIS 344
|
90 100
....*....|....*....|....*..
gi 351064453 221 EVYGDSLVVLLATIVSVADVIFIVLFV 247
Cdd:cd17490 345 EAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
113-442 |
2.53e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 40.18 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 113 GLVLGVKGLLSFLSAPLVGALSDVWG-RKA-------FLILTVLCTCMPIPclKISPWWYFSLFSLSG----LFSVTFSV 180
Cdd:cd17337 35 ALLFTVYGLTVAIASWLSGVLAELFGpRRVmligliiWLVFEVLFLAFGLP--SHNYPLMLLTYGLRGfgypLFAYSFLV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 181 ILAYVadiTDKSERSSAYGLVSATFAASLvtsPALGAYIS----EVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRN 256
Cdd:cd17337 113 WITYR---TPAERLGSAVGWFWFAFTGGL---PVLGSYLAsftiPVIGEIGTLWLSLVFVALGGLIALFLVRDRTGEQPL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 257 TGSVSQITPnevfnwqsaDPFGSLRIVWEDKLVLqLATIV-FLSYLPESGQFSCFFVYLKLVVGFSPEAVAMYIGLVGIL 335
Cdd:cd17337 187 ANPSEEPLK---------ELLSGITILFRNPKIA-IGGIVrIINTLSQFGFPVFMPLYFTDTGGFSTSQWLQIWGIIFLV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 336 SVVAQTGFlHCLTSRFGTKHTITL-GLIFQLIQ--LTWYG---LGTQYWMMWSAGVLAAMSSITYPSISAFVSILSDKDK 409
Cdd:cd17337 257 NIFFNLIF-GILGDKIGWRRTVRWfGGVGCAIStlLFYYVpqlFGHNYWAALIAAILFGIGLAGFVPLSALMPSLAPEHK 335
|
330 340 350
....*....|....*....|....*....|...
gi 351064453 410 qGTVQGVITGIRGLCTGFGPALFGTVFYLFDVD 442
Cdd:cd17337 336 -GAAMSILNLGAGLSNFVGPAIVTLFLGSFGAG 367
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
54-242 |
3.53e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 39.82 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 54 VFGRKKAKDRAEKgHPYVEASVSHALVVI------FLEYFAWGLLTVPVINVLAETFPTNKFLMNGLVLgVKGLLSFLSA 127
Cdd:cd17369 204 VFRRAKEAGQVVR-APLVEVLRRHWRALLlaiglrLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVL-IASVVAAITI 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 128 PLVGALSDVWGRKA-FLILTVLCTCMPIPCLKI----SPWWYF--SLFSLSGLFSVTFSVILAYVADITDKSERSSAYGL 200
Cdd:cd17369 282 PLFGWLSDRVGRRPvYLAGALLAALFAFPFFWLldtgSTWLIVlaAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASL 361
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 351064453 201 ---VSATFAASL--VTSPALGAYISEVYGDSLVVLLATIVSVADVIF 242
Cdd:cd17369 362 gyqLGAILGGGFapLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
106-243 |
3.90e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.56 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 106 TNKFLMNGLVLGVKGLLSFLSAPLVGALSDVWG-RKAFLILTVLCTCMPIPCLKISPWWyfSLFSLSGLFSVTFSVIL-- 182
Cdd:cd17391 236 SNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGhHRILLGALLASALLYIPQAFVQTPW--QLGILRFLLGLATGGLLpa 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 351064453 183 --AYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFI 243
Cdd:cd17391 314 inSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWS 376
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
94-263 |
5.15e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 5.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 94 VPVINVLAETFPTNKFLMnGLVLGVKGLLSFLSAPLVGALSDVWG-RKAFLILTVLCTCM--PIPCLKISPWWYFSLFSL 170
Cdd:cd17490 16 VPFLSPYAESLGASLSMI-GIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLasLIMILFPSPWGLLIARFL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 171 SGLFSVTFSVILAYVADITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPES 250
Cdd:cd17490 95 SGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEER 174
|
170
....*....|...
gi 351064453 251 LPSRRNTGSVSQI 263
Cdd:cd17490 175 REKKPVLTELKEL 187
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
114-207 |
5.32e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 39.28 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 114 LVLGVKGLLSFLSAPLVGALSDVWGRKAFLILTvlcTCMPIPCLKISPWWYFS----------LFSLSGLFSVTFSVILA 183
Cdd:cd17368 262 LVTLLAGVANFIWAPLGGALSDRIGRRPVLLVI---TLAALVTLYPVFAWLTAapsfgrlllvLLVLSFFFGMYGGAMVV 338
|
90 100
....*....|....*....|....
gi 351064453 184 YVADITDKSERSSAYGLVSATFAA 207
Cdd:cd17368 339 ALVELFPVRVRSTGFSLVYALAVA 362
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
121-436 |
5.83e-03 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 39.41 E-value: 5.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 121 LLSFLSAPLVGALSDVWGRKAFLI-------------LTVLCTCMPIPCLKISPWwyfsLFSLSGLFSVTFSVILAYVAD 187
Cdd:cd17449 76 LVGLFSVTLLGPWSDSVGRRPVLIlpslglalqaavyLLVMYLQLHVAYFLIGRI----LSGLLGDFNGILAGCFAYVAD 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 188 ITDKSERSSAYGLVSATFAASLVTSPALGAYISEVYGDSLVVLLATIVSVADVIFIVLFVPESLPSRRNTGSVSQITPNE 267
Cdd:cd17449 152 VSDRRSRTFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRHHQS 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 268 VFNWQSAD-PFGSLRIVWEDKLVLQLATIVFLsylpesGQFSCFFVY-LKLVVGFSPEAVAmYIGLVGILSVVAQTGFLH 345
Cdd:cd17449 232 VVRLYVAPaPNGSRRKLALYSLALFVVVTVHF------GAKDLLVLYeLSSPLCWDSDLIG-YGSAAEHLTYLSSLLGLR 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351064453 346 CLTSRFGTKHTITLGLIFQLIQLTWYGLGTQYWMMWSAGVLAAMSSITYPSISAFVSILSDKDKQGTVQGVITGIRGLCT 425
Cdd:cd17449 305 LLQLCLEDTWVAEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASVACVEGLCS 384
|
330
....*....|.
gi 351064453 426 GFGPALFGTVF 436
Cdd:cd17449 385 LVATGIFNSLY 395
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
80-247 |
6.88e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.93 E-value: 6.88e-03
10 20 30 40 50 60 70 80
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gi 351064453 80 VVIFLEYFAWGLLT------VPVINVLAETFPTnkflmngLVLGVKGLLSFLSAPLVGALSDVWGRK------AFLILTV 147
Cdd:cd17314 213 IAIFLVLIGGFLFIanmaslVRSLQLDAPSFVT-------KLMSIYGLFNAFGRLLWGIVADFFGGRlstlsiLLTILGL 285
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90 100 110 120 130 140 150 160
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gi 351064453 148 LCTCMPIPcLKISPWWYFSLFSLSGlFSVTFSVILAYVADITDKSERSSA--YGLVSATFAASLVTSPALGAYISEVYGD 225
Cdd:cd17314 286 GLCAFLFL-LKMTPVGLVLTGSLLG-FSYGGLFTVYPATVSTVFGTESFAtlYGILLFAPAIGSILGPMLGAKFYDRTPS 363
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170 180
....*....|....*....|..
gi 351064453 226 SLVVLLATIVSVADVIFIVLFV 247
Cdd:cd17314 364 YISAVYIYAVIVFLASAILLAV 385
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