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Conserved domains on  [gi|351063811|emb|CCD72029|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 18324792)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 225-365 2.20e-38

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 135.01  E-value: 2.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063811  225 SFDAINDVLKSIGILSAKSVLLDWFHTFEITVLLKYFKPGILEDLTIKCLESDEEFtGNLVYLEQWKKAKNLKLSKVPNF 304
Cdd:pfam01827   3 IIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQF-EEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351063811  305 PIIVEHLDNFKslNFDFHGEPFSRDDIMKLRDeVLLKSTKFEYFSCKNVKFNTKMFVKVFD 365
Cdd:pfam01827  82 SFPIEHLFHFE--EFDIKLDSFSVEDAIKIRD-ILLKSSTFQSCTIRSPDLNPIEIAKVFD 139
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 36-84 3.71e-08

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


:

Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 49.44  E-value: 3.71e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 351063811   36 PRAVRILILHQHLQGIPVFNAYKAMNKVFGDHFMEYRHFEYWYMGLANG 84
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRSG 49
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 113-147 1.87e-06

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 44.40  E-value: 1.87e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 351063811 113 ILDKLNPIDRFAARAVCRGFKSMIDYQHSNLKTMT 147
Cdd:cd22150   12 ILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 225-365 2.20e-38

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 135.01  E-value: 2.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063811  225 SFDAINDVLKSIGILSAKSVLLDWFHTFEITVLLKYFKPGILEDLTIKCLESDEEFtGNLVYLEQWKKAKNLKLSKVPNF 304
Cdd:pfam01827   3 IIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQF-EEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351063811  305 PIIVEHLDNFKslNFDFHGEPFSRDDIMKLRDeVLLKSTKFEYFSCKNVKFNTKMFVKVFD 365
Cdd:pfam01827  82 SFPIEHLFHFE--EFDIKLDSFSVEDAIKIRD-ILLKSSTFQSCTIRSPDLNPIEIAKVFD 139
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 36-84 3.71e-08

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 49.44  E-value: 3.71e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 351063811   36 PRAVRILILHQHLQGIPVFNAYKAMNKVFGDHFMEYRHFEYWYMGLANG 84
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRSG 49
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 113-147 1.87e-06

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 44.40  E-value: 1.87e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 351063811 113 ILDKLNPIDRFAARAVCRGFKSMIDYQHSNLKTMT 147
Cdd:cd22150   12 ILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
112-145 2.41e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.27  E-value: 2.41e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 351063811   112 MILDKLNPIDRFAARAVCRGFKSMIDYQHSNLKT 145
Cdd:smart00256   8 EILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 112-144 4.66e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.82  E-value: 4.66e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 351063811  112 MILDKLNPIDRFAARAVCRGFKSMIDYQHSNLK 144
Cdd:pfam00646  11 EILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 225-365 2.20e-38

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 135.01  E-value: 2.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351063811  225 SFDAINDVLKSIGILSAKSVLLDWFHTFEITVLLKYFKPGILEDLTIKCLESDEEFtGNLVYLEQWKKAKNLKLSKVPNF 304
Cdd:pfam01827   3 IIESFLNILKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQF-EEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351063811  305 PIIVEHLDNFKslNFDFHGEPFSRDDIMKLRDeVLLKSTKFEYFSCKNVKFNTKMFVKVFD 365
Cdd:pfam01827  82 SFPIEHLFHFE--EFDIKLDSFSVEDAIKIRD-ILLKSSTFQSCTIRSPDLNPIEIAKVFD 139
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 36-84 3.71e-08

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 49.44  E-value: 3.71e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 351063811   36 PRAVRILILHQHLQGIPVFNAYKAMNKVFGDHFMEYRHFEYWYMGLANG 84
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRSG 49
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 113-147 1.87e-06

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 44.40  E-value: 1.87e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 351063811 113 ILDKLNPIDRFAARAVCRGFKSMIDYQHSNLKTMT 147
Cdd:cd22150   12 ILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
FBOX smart00256
A Receptor for Ubiquitination Targets;
112-145 2.41e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 41.27  E-value: 2.41e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 351063811   112 MILDKLNPIDRFAARAVCRGFKSMIDYQHSNLKT 145
Cdd:smart00256   8 EILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 112-144 4.66e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.82  E-value: 4.66e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 351063811  112 MILDKLNPIDRFAARAVCRGFKSMIDYQHSNLK 144
Cdd:pfam00646  11 EILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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