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Conserved domains on  [gi|373219735|emb|CCD69848|]
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Glutamate-rich WD repeat-containing protein 1 [Caenorhabditis elegans]

Protein Classification

WD repeat RBAP46/RBAP48/MSI1 family protein( domain architecture ID 12115235)

WD repeat RBAP46/RBAP48/MSI1 family protein binds histones, similar to human histone-binding proteins RBBP4 and RBBP7

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042393
PubMed:  10322433|30069656|29026209|21468892
SCOP:  4005630|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-399 6.03e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 6.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 164 HYGGINRIRSDRLGDSTVCAcwSDQGRVQVWNITDAlnythgmsgesktevqkidRPLFTNNGSGKEGYGLAWSSlktgD 243
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATG-------------------LLLRTLTGHTGAVRSVAFSP----D 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 244 ---LATGDIIKKIYLWQMKEGGQWAVganpLTGHKKSVEDLAWSPTETgLLASCSADGSIKLWDTRSapkDACVCTVqKA 320
Cdd:COG2319  132 gktLASGSADGTVRLWDLATGKLLRT----LTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLAT---GKLLRTL-TG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 321 HESDVNVISWNRHENLIVSGGDDGELKIWSLKTiqfGQPVALFKYHNSPITSVDWHPHETTtfMASGEDDQT-TIWDIAT 399
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT---GKLLRTLTGHSGSVRSVAFSPDGRL--LASGSADGTvRLWDLAT 277
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 54-122 3.79e-10

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


:

Pssm-ID: 463513  Cd Length: 69  Bit Score: 55.66  E-value: 3.79e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 373219735   54 GEELDFDPSA---YKLFHSFNSDWPCLSFDVVKDglgENRTQFPAECYIVSGTQADKPRDNEIIVMGLKNLT 122
Cdd:pfam12265   1 EEYLIWKKNApflYDMLHTHALEWPSLSFDWFPD---TSEGKNYTVQRLLLGTQTSGAEQNYLYVAKVSLPS 69
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-399 6.03e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 6.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 164 HYGGINRIRSDRLGDSTVCAcwSDQGRVQVWNITDAlnythgmsgesktevqkidRPLFTNNGSGKEGYGLAWSSlktgD 243
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATG-------------------LLLRTLTGHTGAVRSVAFSP----D 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 244 ---LATGDIIKKIYLWQMKEGGQWAVganpLTGHKKSVEDLAWSPTETgLLASCSADGSIKLWDTRSapkDACVCTVqKA 320
Cdd:COG2319  132 gktLASGSADGTVRLWDLATGKLLRT----LTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLAT---GKLLRTL-TG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 321 HESDVNVISWNRHENLIVSGGDDGELKIWSLKTiqfGQPVALFKYHNSPITSVDWHPHETTtfMASGEDDQT-TIWDIAT 399
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT---GKLLRTLTGHSGSVRSVAFSPDGRL--LASGSADGTvRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-401 1.25e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 182 CACWSDQGR----------VQVWNITDalnythgmsgesktevqkiDRPLFTNNGSGKEGYGLAWSSlKTGDLATGDIIK 251
Cdd:cd00200   14 CVAFSPDGKllatgsgdgtIKVWDLET-------------------GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 252 KIYLWQMKEGGQwavgANPLTGHKKSVEDLAWSPTETgLLASCSADGSIKLWDTRSAPKdacvCTVQKAHESDVNVISWN 331
Cdd:cd00200   74 TIRLWDLETGEC----VRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKC----LTTLRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 332 RHENLIVSGGDDGELKIWSLKTiqfGQPVALFKYHNSPITSVDWHPhETTTFMASGEDDQTTIWDIATEA 401
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRT---GKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGK 210
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 54-122 3.79e-10

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 55.66  E-value: 3.79e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 373219735   54 GEELDFDPSA---YKLFHSFNSDWPCLSFDVVKDglgENRTQFPAECYIVSGTQADKPRDNEIIVMGLKNLT 122
Cdd:pfam12265   1 EEYLIWKKNApflYDMLHTHALEWPSLSFDWFPD---TSEGKNYTVQRLLLGTQTSGAEQNYLYVAKVSLPS 69
PTZ00420 PTZ00420
coronin; Provisional
 256-352 1.19e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.19  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 256 WQMKEGGqwAVGA--------NP----LTGHKKSVEDLAWSPTETGLLASCSADGSIKLWDTRSapKDACVCTVQ----- 318
Cdd:PTZ00420  45 WEVEGGG--LIGAirlenqmrKPpvikLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPH--NDESVKEIKdpqci 120

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 373219735 319 -KAHESDVNVISWNRHENLIV-SGGDDGELKIWSLK 352
Cdd:PTZ00420 121 lKGHKKKISIIDWNPMNYYIMcSSGFDSFVNIWDIE 156
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-304 1.58e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 373219735   271 LTGHKKSVEDLAWSPTETgLLASCSADGSIKLWD 304
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
271-304 5.86e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 5.86e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 373219735  271 LTGHKKSVEDLAWSPTETgLLASCSADGSIKLWD 304
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
164-399 6.03e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 6.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 164 HYGGINRIRSDRLGDSTVCAcwSDQGRVQVWNITDAlnythgmsgesktevqkidRPLFTNNGSGKEGYGLAWSSlktgD 243
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATG-------------------LLLRTLTGHTGAVRSVAFSP----D 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 244 ---LATGDIIKKIYLWQMKEGGQWAVganpLTGHKKSVEDLAWSPTETgLLASCSADGSIKLWDTRSapkDACVCTVqKA 320
Cdd:COG2319  132 gktLASGSADGTVRLWDLATGKLLRT----LTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLAT---GKLLRTL-TG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 321 HESDVNVISWNRHENLIVSGGDDGELKIWSLKTiqfGQPVALFKYHNSPITSVDWHPHETTtfMASGEDDQT-TIWDIAT 399
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT---GKLLRTLTGHSGSVRSVAFSPDGRL--LASGSADGTvRLWDLAT 277
WD40 COG2319
WD40 repeat [General function prediction only];
178-399 1.24e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 1.24e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 178 DSTVCACWSDQGRVQVWNITDAlnythgmsgesktevqkidRPLFTNNGSGKEGYGLAWSSlktgD---LATGDIIKKIY 254
Cdd:COG2319  215 DGKLLASGSADGTVRLWDLATG-------------------KLLRTLTGHSGSVRSVAFSP----DgrlLASGSADGTVR 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 255 LWQMKEGGQWAVganpLTGHKKSVEDLAWSPTETgLLASCSADGSIKLWDTRSApkdACVCTVqKAHESDVNVISWNRHE 334
Cdd:COG2319  272 LWDLATGELLRT----LTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATG---KLLRTL-TGHTGAVRSVAFSPDG 342

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 373219735 335 NLIVSGGDDGELKIWSLKTiqfGQPVALFKYHNSPITSVDWHPHETTtfMASGEDDQT-TIWDIAT 399
Cdd:COG2319  343 KTLASGSDDGTVRLWDLAT---GELLRTLTGHTGAVTSVAFSPDGRT--LASGSADGTvRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-401 1.25e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.88  E-value: 1.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 182 CACWSDQGR----------VQVWNITDalnythgmsgesktevqkiDRPLFTNNGSGKEGYGLAWSSlKTGDLATGDIIK 251
Cdd:cd00200   14 CVAFSPDGKllatgsgdgtIKVWDLET-------------------GELLRTLKGHTGPVRDVAASA-DGTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 252 KIYLWQMKEGGQwavgANPLTGHKKSVEDLAWSPTETgLLASCSADGSIKLWDTRSAPKdacvCTVQKAHESDVNVISWN 331
Cdd:cd00200   74 TIRLWDLETGEC----VRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKC----LTTLRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 332 RHENLIVSGGDDGELKIWSLKTiqfGQPVALFKYHNSPITSVDWHPhETTTFMASGEDDQTTIWDIATEA 401
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRT---GKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGK 210
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-396 1.42e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 1.42e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 178 DSTVCACWSDqGRVQVWNITdalnythgmSGESKTEVQkidrplftnngsGKEGYGLAWSSLKTGD-LATGDIIKKIYLW 256
Cdd:cd00200  105 GRILSSSSRD-KTIKVWDVE---------TGKCLTTLR------------GHTDWVNSVAFSPDGTfVASSSQDGTIKLW 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 257 QMKEGGQWAVganpLTGHKKSVEDLAWSPTEtGLLASCSADGSIKLWDTRSapkDACVCTVQkAHESDVNVISWNRHENL 336
Cdd:cd00200  163 DLRTGKCVAT----LTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLST---GKCLGTLR-GHENGVNSVAFSPDGYL 233

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 373219735 337 IVSGGDDGELKIWSLKTiqfGQPVALFKYHNSPITSVDWHPheTTTFMASGEDDQTT-IWD 396
Cdd:cd00200  234 LASGSEDGTIRVWDLRT---GECVQTLSGHTNSVTSLAWSP--DGKRLASGSADGTIrIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 271-399 4.41e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 4.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 271 LTGHKKSVEDLAWSPtETGLLASCSADGSIKLWDTrsapKDACVCTVQKAHESDVNVISWNRHENLIVSGGDDGELKIWS 350
Cdd:cd00200    5 LKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDL----ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 373219735 351 LKTiqfGQPVALFKYHNSPITSVDWHPHetTTFMASGEDDQTT-IWDIAT 399
Cdd:cd00200   80 LET---GECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIkVWDVET 124
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 319-431 2.99e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 2.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 319 KAHESDVNVISWNRHENLIVSGGDDGELKIWSLKTiqfGQPVALFKYHNSPITSVDWHPHetTTFMASGEDDQTT-IWDI 397
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASAD--GTYLASGSSDKTIrLWDL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 373219735 398 ATEADGQTnIEGvppqlmfvHmgQNEVKEVHWHQ 431
Cdd:cd00200   81 ETGECVRT-LTG--------H--TSYVSSVAFSP 103
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 54-122 3.79e-10

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 55.66  E-value: 3.79e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 373219735   54 GEELDFDPSA---YKLFHSFNSDWPCLSFDVVKDglgENRTQFPAECYIVSGTQADKPRDNEIIVMGLKNLT 122
Cdd:pfam12265   1 EEYLIWKKNApflYDMLHTHALEWPSLSFDWFPD---TSEGKNYTVQRLLLGTQTSGAEQNYLYVAKVSLPS 69
WD40 COG2319
WD40 repeat [General function prediction only];
263-399 2.64e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 2.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 263 QWAVGANPLTGHKKSVEDLAWSPTeTGLLASCSADGSIKLWDTRSAPKDAcvctVQKAHESDVNVISWNRHENLIVSGGD 342
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPD-GARLAAGAGDLTLLLLDAAAGALLA----TLLGHTAAVLSVAFSPDGRLLASASA 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 373219735 343 DGELKIWSLKTiqfGQPVALFKYHNSPITSVDWHPHETTtfMASGEDDQT-TIWDIAT 399
Cdd:COG2319   99 DGTVRLWDLAT---GLLLRTLTGHTGAVRSVAFSPDGKT--LASGSADGTvRLWDLAT 151
PTZ00420 PTZ00420
coronin; Provisional
 256-352 1.19e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 54.19  E-value: 1.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 256 WQMKEGGqwAVGA--------NP----LTGHKKSVEDLAWSPTETGLLASCSADGSIKLWDTRSapKDACVCTVQ----- 318
Cdd:PTZ00420  45 WEVEGGG--LIGAirlenqmrKPpvikLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPH--NDESVKEIKdpqci 120

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 373219735 319 -KAHESDVNVISWNRHENLIV-SGGDDGELKIWSLK 352
Cdd:PTZ00420 121 lKGHKKKISIIDWNPMNYYIMcSSGFDSFVNIWDIE 156
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-304 1.58e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.58e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 373219735   271 LTGHKKSVEDLAWSPTETgLLASCSADGSIKLWD 304
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
271-304 5.86e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 5.86e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 373219735  271 LTGHKKSVEDLAWSPTETgLLASCSADGSIKLWD 304
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 314-350 1.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.22e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 373219735   314 VCTVQKAHESDVNVISWNRHENLIVSGGDDGELKIWS 350
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 233-403 3.25e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 3.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 233 GLAWSSLKTGDLATGDIIKKIYLW---------QMKEggqwavganpltgHKKSVEDLAWSPTETGLLASCSADGSIKLW 303
Cdd:PLN00181 537 GICWNSYIKSQVASSNFEGVVQVWdvarsqlvtEMKE-------------HEKRVWSIDYSSADPTLLASGSDDGSVKLW 603

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 304 DTRSA------PKDACVCTVQKAHESDVNviswnrhenlIVSGGDDGELKIWSLKTIQFgqPVALFKYHNSPITSVDWhp 377
Cdd:PLN00181 604 SINQGvsigtiKTKANICCVQFPSESGRS----------LAFGSADHKVYYYDLRNPKL--PLCTMIGHSKTVSYVRF-- 669

                        170       180
                 ....*....|....*....|....*.
gi 373219735 378 HETTTFMASGEDDQTTIWDIATEADG 403
Cdd:PLN00181 670 VDSSTLVSSSTDNTLKLWDLSMSISG 695
WD40 pfam00400
WD domain, G-beta repeat;
319-350 1.64e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.64e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 373219735  319 KAHESDVNVISWNRHENLIVSGGDDGELKIWS 350
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 281-375 3.02e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735  281 LAWSPTeTGLLASCSADGSI--------KLWDTrsapkdacvctVQKAHESDVNVISWNRHENLIVSGGDDGELKIWSLK 352
Cdd:pfam12894   1 MSWCPT-MDLIALATEDGELllhrlnwqRVWTL-----------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAE 68

                          90       100
                  ....*....|....*....|...
gi 373219735  353 TiqfGQPVALFKYHNSPITSVDW 375
Cdd:pfam12894  69 N---GKIVHHFSAGSDLITCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 357-396 8.20e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 8.20e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 373219735   357 GQPVALFKYHNSPITSVDWHPHEttTFMASGEDDQT-TIWD 396
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDG--KYLASGSDDGTiKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 266-376 1.39e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219735 266 VGANP--LTGHKKSVEDLAWSPTETGLLASCSADGSIKLWDTrsaPKDACVCTVQ------KAHESDVNVISWN-RHENL 336
Cdd:PTZ00421  64 LASNPpiLLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGI---PEEGLTQNISdpivhlQGHTKKVGIVSFHpSAMNV 140

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 373219735 337 IVSGGDDGELKIWSLKTiqfGQPVALFKYHNSPITSVDWH 376
Cdd:PTZ00421 141 LASAGADMVVNVWDVER---GKAVEVIKCHSDQITSLEWN 177
WD40 pfam00400
WD domain, G-beta repeat;
357-396 2.16e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 373219735  357 GQPVALFKYHNSPITSVDWHPHEttTFMASGEDDQT-TIWD 396
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG--KLLASGSDDGTvKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 271-348 2.50e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.26  E-value: 2.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 373219735 271 LTGHKKSVEDLAWSPTETGLLASCSADGSIKLWDTRSapkdACVCTVQKAHESDVNVISWNRHENLIVSGGDDGELKI 348
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER----GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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