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Insulin-degrading enzyme [Caenorhabditis elegans]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
16-951
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 760.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 16 I V K GAQ D A R E YR GLE L T NG IR VLLVSDP TT DKSAAAL D V K VG HLM DP WELP GLAHF C EHMLFLGT A KYP SEN EY SK F LAA 95
Cdd:COG1025 35 I I K SPN D P R Q YR AIT L D NG LK VLLVSDP QA DKSAAAL A V P VG SFD DP DDQQ GLAHF L EHMLFLGT K KYP EPG EY QE F ISK 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 96 H A GS S NA Y T SSDH TNY H F D V KP D Q L PG ALDRF VQ FF LS P Q F TESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 175
Cdd:COG1025 115 H G GS H NA S T ATER TNY Y F E V EN D A L EE ALDRF AD FF AA P L F DPEYVD RE RN AV NA E YTLKRSD D GR R IY QV HKETLN P A H 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 176 DYGK F GT GN KQ TL led AR K K G IEP RD A LL Q F HKKW YS SDI M TCCIVGKEP L NV LE S y L GTLE F D AI E N KKVERKVWEEFP 255
Cdd:COG1025 195 PFSR F SV GN LE TL --- SD K P G SKL RD E LL A F YQRY YS ANL M KLVLYSNQS L DE LE K - L ARQT F G AI P N RNLSVPPITVPL 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 256 Y G P D QL AKR I DV VP I K DT R LVSIS FP F P DLNGEFL S Q P GH YIS H L I G H EG P GSLL SE LK RL G WVS SL QSDSHTQAAG FG V 335
Cdd:COG1025 271 Y T P E QL GII I HI VP L K PR R QLRLE FP I P NNQAYYR S K P LT YIS Y L L G N EG E GSLL DW LK KQ G LAE SL SAGGGISGRN FG D 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 336 YNVTMD L STE GL E H V DEII QLM F N YI GMLQSA G PKQ W VH DE L A E L SAVK FRF KD K EQ PM TMAINVAASLQYI P F E HI L SS 415
Cdd:COG1025 351 FSISVS L TDK GL A H R DEII AAV F A YI ELIRQQ G IQE W YF DE Q A Q L LELA FRF QE K TR PM DYVSWLSDNMLRY P V E DV L DA 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 416 R YL LTKYE P ER I KEL L SM L S P A N MQVRVV S Q kfk GQEGNTNEPV Y G T EMK V TD I SP E TMK K YEN A LKTS hh AL H LPE K N E 495
Cdd:COG1025 431 D YL MDGFD P AA I RAR L AQ L T P E N ARIWLI S P --- DVPTDKTAYW Y D T PYS V DP I TQ E QLA K WQQ A SQNP -- AL S LPE L N P 505
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 496 YI ATN F DQKPRES v KNEH P R L IS D DGWS R V W FKQ D DEYNM PK QETK L A L TT P MVAQNP R MSL L SS L WLWC L S D T L A E ET Y 575
Cdd:COG1025 506 YI PDD F SLIKLDK - ESAK P E L LV D EPGL R L W YMP D QYFAE PK ADIY L S L RN P QAVDSA R NQV L TR L LDYL L N D A L N E LS Y 584
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 576 N A DL AGL KCQ L ESSPF G vqmrvsnrreaerhas LTL HVY G YDE KQ ALFAKH L ANRMTN F KIDKT RF DVLFES L K R A L T N H 655
Cdd:COG1025 585 Q A SV AGL SYS L YAHQG G ---------------- LTL SAS G FTQ KQ PKLLEA L LDQLAS F EPTEE RF AQAKSQ L L R Q L D N A 648
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 656 AFSQ PY - L L TQHYNQ LL IVDK v WSK E Q LLA VCD S V TL E D VQG F AKEM LQ AF H M E LF V H GN ST E KE A I QL SKE L MDV L KSA 734
Cdd:COG1025 649 EKAK PY s Q L FSPLSR LL QPPY - FER E E LLA ALE S I TL Q D LRA F REQL LQ QL H L E ML V V GN LS E EQ A K QL ADS L KKQ L APN 727
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 735 APNSR P lyrnehn P R RELQ L NNGDEYVYRHLQKTH D VGCVEV t YQ I G VQNTYDN A VVG L ID Q L I REPA FN T LRT N E A LGY 814
Cdd:COG1025 728 GTGEE P ------- R R QVVD L DKSGSLNLEKACDHT D SALLIY - YQ S G YDSLASM A LSS L LG Q I I SPWF FN Q LRT E E Q LGY 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 815 I V WT G S r LNC G TVA - L NVI VQ G P - K S VDHV LERI EV FL ESVRKEIAEMPQ EEF DNQVS G M I AR L E E KPKT LS SRFR R F W N 892
Cdd:COG1025 800 V V GA G Y - MPL G RQP g L GFY VQ S P v A S PAYL LERI DD FL KQFEERLLALSE EEF AQYKQ G L I NQ L L E PDQN LS EEAQ R L W V 878
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 373219410 893 E I ECRQYN F AR RE EEV A LL K TIKKD D VLEL F DKKIRKDAAE R rk L AVFVH G KNEDQEAV 951
Cdd:COG1025 879 D I GNGDFE F DT RE KLI A AV K KLTRA D LIDF F QQAVIAPQGL R -- L LSQSQ G TKHSKADE 935
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
16-951
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 760.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 16 I V K GAQ D A R E YR GLE L T NG IR VLLVSDP TT DKSAAAL D V K VG HLM DP WELP GLAHF C EHMLFLGT A KYP SEN EY SK F LAA 95
Cdd:COG1025 35 I I K SPN D P R Q YR AIT L D NG LK VLLVSDP QA DKSAAAL A V P VG SFD DP DDQQ GLAHF L EHMLFLGT K KYP EPG EY QE F ISK 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 96 H A GS S NA Y T SSDH TNY H F D V KP D Q L PG ALDRF VQ FF LS P Q F TESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 175
Cdd:COG1025 115 H G GS H NA S T ATER TNY Y F E V EN D A L EE ALDRF AD FF AA P L F DPEYVD RE RN AV NA E YTLKRSD D GR R IY QV HKETLN P A H 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 176 DYGK F GT GN KQ TL led AR K K G IEP RD A LL Q F HKKW YS SDI M TCCIVGKEP L NV LE S y L GTLE F D AI E N KKVERKVWEEFP 255
Cdd:COG1025 195 PFSR F SV GN LE TL --- SD K P G SKL RD E LL A F YQRY YS ANL M KLVLYSNQS L DE LE K - L ARQT F G AI P N RNLSVPPITVPL 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 256 Y G P D QL AKR I DV VP I K DT R LVSIS FP F P DLNGEFL S Q P GH YIS H L I G H EG P GSLL SE LK RL G WVS SL QSDSHTQAAG FG V 335
Cdd:COG1025 271 Y T P E QL GII I HI VP L K PR R QLRLE FP I P NNQAYYR S K P LT YIS Y L L G N EG E GSLL DW LK KQ G LAE SL SAGGGISGRN FG D 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 336 YNVTMD L STE GL E H V DEII QLM F N YI GMLQSA G PKQ W VH DE L A E L SAVK FRF KD K EQ PM TMAINVAASLQYI P F E HI L SS 415
Cdd:COG1025 351 FSISVS L TDK GL A H R DEII AAV F A YI ELIRQQ G IQE W YF DE Q A Q L LELA FRF QE K TR PM DYVSWLSDNMLRY P V E DV L DA 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 416 R YL LTKYE P ER I KEL L SM L S P A N MQVRVV S Q kfk GQEGNTNEPV Y G T EMK V TD I SP E TMK K YEN A LKTS hh AL H LPE K N E 495
Cdd:COG1025 431 D YL MDGFD P AA I RAR L AQ L T P E N ARIWLI S P --- DVPTDKTAYW Y D T PYS V DP I TQ E QLA K WQQ A SQNP -- AL S LPE L N P 505
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 496 YI ATN F DQKPRES v KNEH P R L IS D DGWS R V W FKQ D DEYNM PK QETK L A L TT P MVAQNP R MSL L SS L WLWC L S D T L A E ET Y 575
Cdd:COG1025 506 YI PDD F SLIKLDK - ESAK P E L LV D EPGL R L W YMP D QYFAE PK ADIY L S L RN P QAVDSA R NQV L TR L LDYL L N D A L N E LS Y 584
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 576 N A DL AGL KCQ L ESSPF G vqmrvsnrreaerhas LTL HVY G YDE KQ ALFAKH L ANRMTN F KIDKT RF DVLFES L K R A L T N H 655
Cdd:COG1025 585 Q A SV AGL SYS L YAHQG G ---------------- LTL SAS G FTQ KQ PKLLEA L LDQLAS F EPTEE RF AQAKSQ L L R Q L D N A 648
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 656 AFSQ PY - L L TQHYNQ LL IVDK v WSK E Q LLA VCD S V TL E D VQG F AKEM LQ AF H M E LF V H GN ST E KE A I QL SKE L MDV L KSA 734
Cdd:COG1025 649 EKAK PY s Q L FSPLSR LL QPPY - FER E E LLA ALE S I TL Q D LRA F REQL LQ QL H L E ML V V GN LS E EQ A K QL ADS L KKQ L APN 727
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 735 APNSR P lyrnehn P R RELQ L NNGDEYVYRHLQKTH D VGCVEV t YQ I G VQNTYDN A VVG L ID Q L I REPA FN T LRT N E A LGY 814
Cdd:COG1025 728 GTGEE P ------- R R QVVD L DKSGSLNLEKACDHT D SALLIY - YQ S G YDSLASM A LSS L LG Q I I SPWF FN Q LRT E E Q LGY 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 815 I V WT G S r LNC G TVA - L NVI VQ G P - K S VDHV LERI EV FL ESVRKEIAEMPQ EEF DNQVS G M I AR L E E KPKT LS SRFR R F W N 892
Cdd:COG1025 800 V V GA G Y - MPL G RQP g L GFY VQ S P v A S PAYL LERI DD FL KQFEERLLALSE EEF AQYKQ G L I NQ L L E PDQN LS EEAQ R L W V 878
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 373219410 893 E I ECRQYN F AR RE EEV A LL K TIKKD D VLEL F DKKIRKDAAE R rk L AVFVH G KNEDQEAV 951
Cdd:COG1025 879 D I GNGDFE F DT RE KLI A AV K KLTRA D LIDF F QQAVIAPQGL R -- L LSQSQ G TKHSKADE 935
PRK15101
PRK15101 protease3; Provisional
16-929
8.56e-104
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 346.96
E-value: 8.56e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 16 I V K GAQ D A R E Y RGLE L T NG IR VLLVSDP TTD KS A AAL DVK VG H L M DP WELP GLAH FC EHM LFL G TA KYP SENEYSK FL AA 95
Cdd:PRK15101 34 I R K SEK D P R Q Y QAIR L D NG MT VLLVSDP QAV KS L AAL ALP VG S L E DP DAQQ GLAH YL EHM VLM G SK KYP QPDSLAE FL KK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 96 H A GS S NA Y T S S DH T NYHFD V KP D Q LP G A L DR FVQFFLS P QFTESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 175
Cdd:PRK15101 114 H G GS H NA S T A S YR T AFYLE V EN D A LP P A V DR LADAIAE P LLDPKNAD RE RN AV NA E LTMARSR D GM R MA QV SAETIN P A H 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 176 DYGK F GT GN KQ TL LE dar K K G IEPR DAL LQ F HKKW YS SDI M TCC I VGKE PL NV L ES y L GTLE F DAIE NK KVERKVWEEFP 255
Cdd:PRK15101 194 PGSR F SG GN LE TL SD --- K P G SKLQ DAL VD F YQRY YS ANL M KAV I YSNQ PL PE L AK - L AADT F GRVP NK NASVPEITVPV 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 256 YGPD Q LAKR I DV VP IKDTRLVSIS F PFPDLNGE F L S QPGH YIS H LIG HEG PG S L LSE L KRL G WVSSLQSDSHTQAAG - F G 334
Cdd:PRK15101 270 VTDA Q KGII I HY VP AQPRKVLRVE F RIDNNSAK F R S KTDE YIS Y LIG NRS PG T L SDW L QKQ G LAEGISAGADPMVDR n S G 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 335 V YNVTMD L STE GL EHV D EIIQLM F N Y IGM L QSA G PKQWVH DELA ELSAVK FR FKDKEQP M TMAINV A ASLQYI P F EH I L S 414
Cdd:PRK15101 350 V FAISVS L TDK GL AQR D QVVAAI F S Y LNL L REK G IDKSYF DELA HVLDLD FR YPSITRD M DYIEWL A DTMLRV P V EH T L D 429
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 415 SR Y LLTK Y E P ER IK EL L SMLS P A N MQVRVV S QKFK gqegn T N EPV Y GTEM -- K V TD IS PE T MKKY ena LKTSHH - AL H LP 491
Cdd:PRK15101 430 AP Y IADR Y D P KA IK AR L AEMT P Q N ARIWYI S PQEP ----- H N KTA Y FVDA py Q V DK IS EQ T FADW --- QQKAQN i AL S LP 501
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 492 E K N E YI ATN F DQ - K PRESV K ne HP R LI S D DGWS RV WFKQDDEY - NM PK QETK L A L TT P MVAQNP R MSL L SS L WLWCLSDT 569
Cdd:PRK15101 502 E L N P YI PDD F SL i K ADKAY K -- HP E LI V D EPGL RV VYMPSQYF a DE PK ADIS L V L RN P KAMDSA R NQV L FA L NDYLAGLA 579
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 570 L AEETYN A DLA G LKCQL e SSPF G VQMRVS nrreaerhasltlhvy GY DEKQALFAKH L ANRMTN F KID ------- K TRF d 642
Cdd:PRK15101 580 L DQLSNQ A SVG G ISFST - NANN G LMVNAN ---------------- GY TQRLPQLLQA L LEGYFS F TPT eeqlaqa K SWY - 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 643 vl F E S L KR A LTNH A FS Q PYLLT Q HYN Q L livd KVWSKEQLLAVCD S V TL E DV QGFAKEM L QAFHM E LF V H GN S TE KEAIQ 722
Cdd:PRK15101 642 -- R E Q L DS A EKGK A YE Q AIMPA Q MLS Q V ---- PYFERDERRKLLP S I TL K DV LAYRDAL L SGATP E FL V V GN L TE EQVTT 715
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 723 L SKELMDV L KS aap NSRPLY R NEHNPRREL Q LN N gdeyvyrh LQ K T -- HDVGCVEVT Y qig V QNT YD N ---- A VVG L ID Q 796
Cdd:PRK15101 716 L ARDVQKQ L GA --- DGTEWW R GKDVVVDKK Q SV N -------- FE K A gs STDSALAAV Y --- V PTG YD E yqss A YSS L LG Q 781
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 797 L I REPAF N T LRT N E A LGY I V WT g SRLNC G - TVALNVIV Q GP - K SVDHVLE R IEV F LESVRKEIAE M PQ EEF DNQVSGM I A 874
Cdd:PRK15101 782 I I QPWFY N Q LRT E E Q LGY A V FA - FPMSV G r QWGMGFLL Q SN d K QPAYLWQ R YQA F FPQAEAKLRA M KP EEF AQYQQAL I N 860
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*
gi 373219410 875 R L EEK P K TL SSRFR R FWNEIECRQYN F AR R EEEV A LL K TIKKDDVLEL F DKKIRK 929
Cdd:PRK15101 861 Q L LQA P Q TL GEEAS R LSKDFDRGNMR F DS R DKII A QI K LLTPQKLADF F HQAVIE 915
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
385-685
1.00e-85
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 277.53
E-value: 1.00e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 385 FRF KD K EQ P MTMAINV A ASL Q YI P F E H ILS SR YLL TK Y E PE R I K ELL SM L S P A N MQVRV VS QK F K G q E GNTN EP V YGTE M 464
Cdd:pfam16187 1 FRF QE K SP P SDYVSSL A SNM Q PY P P E D ILS GD YLL RE Y D PE L I Q ELL DY L T P E N ARITL VS KE F E G - E TDQK EP W YGTE Y 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 465 K V TD I SP E TM KK YE NA LKT s HHA LHLPE K N EY I A T N FD Q K PR E SVK - NEH P R LI S D DGW SR V W F K Q DD EYNM PK QETK L A 543
Cdd:pfam16187 80 S V EP I PE E LL KK WK NA PEP - NPE LHLPE P N PF I P T D FD L K KK E VKE p AKY P V LI R D TPL SR L W Y K K DD TFWV PK ANIY L S 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 544 L TT P MVAQN PR MSL L SS L WLWC L S D T L A E ET Y N A D LAGL KCQ L ESSPF G vqmrvsnrreaerhas LTL H V Y GY DE K QALF 623
Cdd:pfam16187 159 L RS P LAYSS PR NAV L TR L YVEL L K D S L N E YA Y D A E LAGL SYS L SATER G ---------------- LTL S V S GY ND K LPVL 222
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 373219410 624 AKHLANRMTN F K ID KT RF DVLF E S L K R ALT N H A FS QPY LLTQH Y NQL L IVDKV W SK E QL L AV 685
Cdd:pfam16187 223 LEKILEKLRD F E ID PD RF EIIK E Q L L R SYK N F A LE QPY QQAFD Y LLY L LEERS W TP E EK L EA 284
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
27-413
1.39e-30
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 129.22
E-value: 1.39e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 27 R GLE L T NG I RV L L VSD P TTDKS AA A L D V KV G HLMD P WEL PGLAHF C EH M LFLG TAKYPSENEYSKFLAAHA G SS NA Y T SS 106
Cdd:TIGR02110 1 R RIT L P NG L RV H L YHQ P DAKRA AA L L R V AA G SHDE P SAW PGLAHF L EH L LFLG GERFQGDDRLMPWVQRQG G QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 107 DH T NYH F DVKPDQ L PGA L D R FVQFFLS P QF T ESATE RE VCAVDS E HS nnlnnd L W R fl QVDRSRSK -------- P GH DYG 178
Cdd:TIGR02110 81 RT T AFF F ELPAAA L AAG L A R LCDMLAR P LL T AEDQQ RE REVLEA E YI ------ A W Q -- NDADTLRE aalldalq A GH PLR 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 179 K F GT G NKQT L LEDAR kkgi EPRD AL LQ FH KKW Y SSDI M TCCIV G KEP L NV LE SYLGTLEFDAIENKKVERKVWEEF - PYG 257
Cdd:TIGR02110 153 R F HA G SRDS L ALPNT ---- AFQQ AL RD FH RRH Y QAGN M QLWLQ G PQS L DE LE QLAARFGASLAAGGECAQAPPAPL l RFD 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 258 PDQ LA KRI dvvpik DT RL V s IS F PFPD L NGE f LSQPGHYISHLIGH E G PG S LL SE L KRL G WVS S LQSDSHT Q A AG FGVYN 337
Cdd:TIGR02110 229 RLT LA GGS ------ EP RL W - LL F ALAG L PAT - ARDNVTLLCEFLQD E A PG G LL AQ L RER G LAE S VAATWLY Q D AG QALLA 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 338 VTMDLSTEGLEHVDE I I QL MFNYI G M L QS - AGPK Q WV H -------------- DE LA E L SAVKFR F KDKEQPMTMAINVA A 402
Cdd:TIGR02110 301 LEFSARCISAAAAQQ I E QL LTQWL G A L AE q TWAE Q LE H yaqlaqrrfqtlal SP LA Q L RGRALG F ALGCALPDALTDFL A 380
410
....*....|.
gi 373219410 403 S LQ YI P FEHI L 413
Cdd:TIGR02110 381 A LQ DC P RTRL L 391
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
16-951
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 760.93
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 16 I V K GAQ D A R E YR GLE L T NG IR VLLVSDP TT DKSAAAL D V K VG HLM DP WELP GLAHF C EHMLFLGT A KYP SEN EY SK F LAA 95
Cdd:COG1025 35 I I K SPN D P R Q YR AIT L D NG LK VLLVSDP QA DKSAAAL A V P VG SFD DP DDQQ GLAHF L EHMLFLGT K KYP EPG EY QE F ISK 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 96 H A GS S NA Y T SSDH TNY H F D V KP D Q L PG ALDRF VQ FF LS P Q F TESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 175
Cdd:COG1025 115 H G GS H NA S T ATER TNY Y F E V EN D A L EE ALDRF AD FF AA P L F DPEYVD RE RN AV NA E YTLKRSD D GR R IY QV HKETLN P A H 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 176 DYGK F GT GN KQ TL led AR K K G IEP RD A LL Q F HKKW YS SDI M TCCIVGKEP L NV LE S y L GTLE F D AI E N KKVERKVWEEFP 255
Cdd:COG1025 195 PFSR F SV GN LE TL --- SD K P G SKL RD E LL A F YQRY YS ANL M KLVLYSNQS L DE LE K - L ARQT F G AI P N RNLSVPPITVPL 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 256 Y G P D QL AKR I DV VP I K DT R LVSIS FP F P DLNGEFL S Q P GH YIS H L I G H EG P GSLL SE LK RL G WVS SL QSDSHTQAAG FG V 335
Cdd:COG1025 271 Y T P E QL GII I HI VP L K PR R QLRLE FP I P NNQAYYR S K P LT YIS Y L L G N EG E GSLL DW LK KQ G LAE SL SAGGGISGRN FG D 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 336 YNVTMD L STE GL E H V DEII QLM F N YI GMLQSA G PKQ W VH DE L A E L SAVK FRF KD K EQ PM TMAINVAASLQYI P F E HI L SS 415
Cdd:COG1025 351 FSISVS L TDK GL A H R DEII AAV F A YI ELIRQQ G IQE W YF DE Q A Q L LELA FRF QE K TR PM DYVSWLSDNMLRY P V E DV L DA 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 416 R YL LTKYE P ER I KEL L SM L S P A N MQVRVV S Q kfk GQEGNTNEPV Y G T EMK V TD I SP E TMK K YEN A LKTS hh AL H LPE K N E 495
Cdd:COG1025 431 D YL MDGFD P AA I RAR L AQ L T P E N ARIWLI S P --- DVPTDKTAYW Y D T PYS V DP I TQ E QLA K WQQ A SQNP -- AL S LPE L N P 505
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 496 YI ATN F DQKPRES v KNEH P R L IS D DGWS R V W FKQ D DEYNM PK QETK L A L TT P MVAQNP R MSL L SS L WLWC L S D T L A E ET Y 575
Cdd:COG1025 506 YI PDD F SLIKLDK - ESAK P E L LV D EPGL R L W YMP D QYFAE PK ADIY L S L RN P QAVDSA R NQV L TR L LDYL L N D A L N E LS Y 584
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 576 N A DL AGL KCQ L ESSPF G vqmrvsnrreaerhas LTL HVY G YDE KQ ALFAKH L ANRMTN F KIDKT RF DVLFES L K R A L T N H 655
Cdd:COG1025 585 Q A SV AGL SYS L YAHQG G ---------------- LTL SAS G FTQ KQ PKLLEA L LDQLAS F EPTEE RF AQAKSQ L L R Q L D N A 648
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 656 AFSQ PY - L L TQHYNQ LL IVDK v WSK E Q LLA VCD S V TL E D VQG F AKEM LQ AF H M E LF V H GN ST E KE A I QL SKE L MDV L KSA 734
Cdd:COG1025 649 EKAK PY s Q L FSPLSR LL QPPY - FER E E LLA ALE S I TL Q D LRA F REQL LQ QL H L E ML V V GN LS E EQ A K QL ADS L KKQ L APN 727
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 735 APNSR P lyrnehn P R RELQ L NNGDEYVYRHLQKTH D VGCVEV t YQ I G VQNTYDN A VVG L ID Q L I REPA FN T LRT N E A LGY 814
Cdd:COG1025 728 GTGEE P ------- R R QVVD L DKSGSLNLEKACDHT D SALLIY - YQ S G YDSLASM A LSS L LG Q I I SPWF FN Q LRT E E Q LGY 799
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 815 I V WT G S r LNC G TVA - L NVI VQ G P - K S VDHV LERI EV FL ESVRKEIAEMPQ EEF DNQVS G M I AR L E E KPKT LS SRFR R F W N 892
Cdd:COG1025 800 V V GA G Y - MPL G RQP g L GFY VQ S P v A S PAYL LERI DD FL KQFEERLLALSE EEF AQYKQ G L I NQ L L E PDQN LS EEAQ R L W V 878
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 373219410 893 E I ECRQYN F AR RE EEV A LL K TIKKD D VLEL F DKKIRKDAAE R rk L AVFVH G KNEDQEAV 951
Cdd:COG1025 879 D I GNGDFE F DT RE KLI A AV K KLTRA D LIDF F QQAVIAPQGL R -- L LSQSQ G TKHSKADE 935
PRK15101
PRK15101 protease3; Provisional
16-929
8.56e-104
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 346.96
E-value: 8.56e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 16 I V K GAQ D A R E Y RGLE L T NG IR VLLVSDP TTD KS A AAL DVK VG H L M DP WELP GLAH FC EHM LFL G TA KYP SENEYSK FL AA 95
Cdd:PRK15101 34 I R K SEK D P R Q Y QAIR L D NG MT VLLVSDP QAV KS L AAL ALP VG S L E DP DAQQ GLAH YL EHM VLM G SK KYP QPDSLAE FL KK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 96 H A GS S NA Y T S S DH T NYHFD V KP D Q LP G A L DR FVQFFLS P QFTESATE RE VC AV DS E HSNNLNN D LW R FL QV DRSRSK P G H 175
Cdd:PRK15101 114 H G GS H NA S T A S YR T AFYLE V EN D A LP P A V DR LADAIAE P LLDPKNAD RE RN AV NA E LTMARSR D GM R MA QV SAETIN P A H 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 176 DYGK F GT GN KQ TL LE dar K K G IEPR DAL LQ F HKKW YS SDI M TCC I VGKE PL NV L ES y L GTLE F DAIE NK KVERKVWEEFP 255
Cdd:PRK15101 194 PGSR F SG GN LE TL SD --- K P G SKLQ DAL VD F YQRY YS ANL M KAV I YSNQ PL PE L AK - L AADT F GRVP NK NASVPEITVPV 269
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 256 YGPD Q LAKR I DV VP IKDTRLVSIS F PFPDLNGE F L S QPGH YIS H LIG HEG PG S L LSE L KRL G WVSSLQSDSHTQAAG - F G 334
Cdd:PRK15101 270 VTDA Q KGII I HY VP AQPRKVLRVE F RIDNNSAK F R S KTDE YIS Y LIG NRS PG T L SDW L QKQ G LAEGISAGADPMVDR n S G 349
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 335 V YNVTMD L STE GL EHV D EIIQLM F N Y IGM L QSA G PKQWVH DELA ELSAVK FR FKDKEQP M TMAINV A ASLQYI P F EH I L S 414
Cdd:PRK15101 350 V FAISVS L TDK GL AQR D QVVAAI F S Y LNL L REK G IDKSYF DELA HVLDLD FR YPSITRD M DYIEWL A DTMLRV P V EH T L D 429
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 415 SR Y LLTK Y E P ER IK EL L SMLS P A N MQVRVV S QKFK gqegn T N EPV Y GTEM -- K V TD IS PE T MKKY ena LKTSHH - AL H LP 491
Cdd:PRK15101 430 AP Y IADR Y D P KA IK AR L AEMT P Q N ARIWYI S PQEP ----- H N KTA Y FVDA py Q V DK IS EQ T FADW --- QQKAQN i AL S LP 501
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 492 E K N E YI ATN F DQ - K PRESV K ne HP R LI S D DGWS RV WFKQDDEY - NM PK QETK L A L TT P MVAQNP R MSL L SS L WLWCLSDT 569
Cdd:PRK15101 502 E L N P YI PDD F SL i K ADKAY K -- HP E LI V D EPGL RV VYMPSQYF a DE PK ADIS L V L RN P KAMDSA R NQV L FA L NDYLAGLA 579
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 570 L AEETYN A DLA G LKCQL e SSPF G VQMRVS nrreaerhasltlhvy GY DEKQALFAKH L ANRMTN F KID ------- K TRF d 642
Cdd:PRK15101 580 L DQLSNQ A SVG G ISFST - NANN G LMVNAN ---------------- GY TQRLPQLLQA L LEGYFS F TPT eeqlaqa K SWY - 641
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 643 vl F E S L KR A LTNH A FS Q PYLLT Q HYN Q L livd KVWSKEQLLAVCD S V TL E DV QGFAKEM L QAFHM E LF V H GN S TE KEAIQ 722
Cdd:PRK15101 642 -- R E Q L DS A EKGK A YE Q AIMPA Q MLS Q V ---- PYFERDERRKLLP S I TL K DV LAYRDAL L SGATP E FL V V GN L TE EQVTT 715
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 723 L SKELMDV L KS aap NSRPLY R NEHNPRREL Q LN N gdeyvyrh LQ K T -- HDVGCVEVT Y qig V QNT YD N ---- A VVG L ID Q 796
Cdd:PRK15101 716 L ARDVQKQ L GA --- DGTEWW R GKDVVVDKK Q SV N -------- FE K A gs STDSALAAV Y --- V PTG YD E yqss A YSS L LG Q 781
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 797 L I REPAF N T LRT N E A LGY I V WT g SRLNC G - TVALNVIV Q GP - K SVDHVLE R IEV F LESVRKEIAE M PQ EEF DNQVSGM I A 874
Cdd:PRK15101 782 I I QPWFY N Q LRT E E Q LGY A V FA - FPMSV G r QWGMGFLL Q SN d K QPAYLWQ R YQA F FPQAEAKLRA M KP EEF AQYQQAL I N 860
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*
gi 373219410 875 R L EEK P K TL SSRFR R FWNEIECRQYN F AR R EEEV A LL K TIKKDDVLEL F DKKIRK 929
Cdd:PRK15101 861 Q L LQA P Q TL GEEAS R LSKDFDRGNMR F DS R DKII A QI K LLTPQKLADF F HQAVIE 915
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
385-685
1.00e-85
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 277.53
E-value: 1.00e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 385 FRF KD K EQ P MTMAINV A ASL Q YI P F E H ILS SR YLL TK Y E PE R I K ELL SM L S P A N MQVRV VS QK F K G q E GNTN EP V YGTE M 464
Cdd:pfam16187 1 FRF QE K SP P SDYVSSL A SNM Q PY P P E D ILS GD YLL RE Y D PE L I Q ELL DY L T P E N ARITL VS KE F E G - E TDQK EP W YGTE Y 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 465 K V TD I SP E TM KK YE NA LKT s HHA LHLPE K N EY I A T N FD Q K PR E SVK - NEH P R LI S D DGW SR V W F K Q DD EYNM PK QETK L A 543
Cdd:pfam16187 80 S V EP I PE E LL KK WK NA PEP - NPE LHLPE P N PF I P T D FD L K KK E VKE p AKY P V LI R D TPL SR L W Y K K DD TFWV PK ANIY L S 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 544 L TT P MVAQN PR MSL L SS L WLWC L S D T L A E ET Y N A D LAGL KCQ L ESSPF G vqmrvsnrreaerhas LTL H V Y GY DE K QALF 623
Cdd:pfam16187 159 L RS P LAYSS PR NAV L TR L YVEL L K D S L N E YA Y D A E LAGL SYS L SATER G ---------------- LTL S V S GY ND K LPVL 222
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 373219410 624 AKHLANRMTN F K ID KT RF DVLF E S L K R ALT N H A FS QPY LLTQH Y NQL L IVDKV W SK E QL L AV 685
Cdd:pfam16187 223 LEKILEKLRD F E ID PD RF EIIK E Q L L R SYK N F A LE QPY QQAFD Y LLY L LEERS W TP E EK L EA 284
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
36-174
2.42e-47
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 165.94
E-value: 2.42e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 36 RV LLV SDP TT D K S AAA L DVKV G HLMD P WELP GLAHF C EHM L F L GT A KYPS e NE YSKF L AAHA GS S NA Y TS SDH T N Y HFD V 115
Cdd:pfam00675 1 RV ASE SDP PA D T S TVG L WIDA G SRYE P DNNN GLAHF L EHM A F K GT K KYPS - NE LEEE L EKLG GS L NA F TS REN T V Y YAE V 79
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 116 KP D Q LP G A L DR FVQ FF LS P Q FTES AT ER ------- EV C AVDSE HSN ---- NL NNDLW R FLQVD RS RSK PG 174
Cdd:pfam00675 80 LN D D LP K A V DR LAD FF RN P L FTES EI ER erlvvly EV E AVDSE PQL vvle NL HAAAY R NTPLG RS LLG PG 149
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
16-444
1.00e-42
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 161.63
E-value: 1.00e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 16 IVKG A Q D AR E YR gle L T NG I RV L LV S DP TTDKSAAA L D V K VG HLMD P WELP GLAHF C EHMLF L GT A K YPS e N E YSKF L A A 95
Cdd:COG0612 8 APAA A P D VE E FT --- L P NG L RV I LV P DP EAPVVSVR L W V R VG SRDE P PGKT GLAHF L EHMLF K GT K K RSA - G E IAEE L E A 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 96 HA GS S NA Y TS S D H T N Y HFD V KPDQ L PG AL DRFVQFF L S P Q F T E SAT ERE VCA V DS E HSNNLNNDLWRFLQVDRSRSKPG H 175
Cdd:COG0612 84 LG GS L NA F TS F D Y T V Y YLS V LSED L EL AL ELLADRL L N P T F D E EEL ERE RGV V LE E IRRYEDDPDGLAFEALLAALYGD H 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 176 D YG KFGT G NKQTL ledark KG I e P R DA L LQ F H K KW Y SSDIMTCCI VG ---- K E P L NVL E S Y L G T L E fdai ENKKVE R KV w 251
Cdd:COG0612 164 P YG RPII G TEESI ------ EA I - T R ED L RA F Y K RY Y RPNNAVLVV VG dvdp E E V L ALV E K Y F G D L P ---- AGPAPP R PD - 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 252 eef P YG P D Q LAK R ID VV PIK D TRL -- VSISF P F P DLNG eflsq P GH Y ISHLIGH --- E G PG S L L SELK R -- L G WVS S LQ S 324
Cdd:COG0612 232 --- P AE P P Q TGP R RV VV DDP D AEQ ah ILLGY P G P ARDD ----- P DY Y ALDVLNE ilg G G FS S R L FQEL R ek K G LAY S VG S 303
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 325 d S HTQAAGF G VYNVTMDLST egl EHVD E IIQLMFNYIGM L QSA G PKQ wvhdel A EL SAV K FRFK ----- DK E QPMTM A IN 399
Cdd:COG0612 304 - S FSPYRDA G LFTIYAGTAP --- DKLE E ALAAILEELER L AKE G VTE ------ E EL ERA K NQLL gslal SL E SNSGL A SQ 373
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 373219410 400 VAASLQ Y ipfeh ILSSR YL LTKY E ------ P E RIKELL - SM L S P A N MQ V R VV 444
Cdd:COG0612 374 LGRYEL Y ----- GGDLD YL EEYL E rieavt A E DVQAVA r KY L D P D N LV V V VV 420
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
27-413
1.39e-30
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 129.22
E-value: 1.39e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 27 R GLE L T NG I RV L L VSD P TTDKS AA A L D V KV G HLMD P WEL PGLAHF C EH M LFLG TAKYPSENEYSKFLAAHA G SS NA Y T SS 106
Cdd:TIGR02110 1 R RIT L P NG L RV H L YHQ P DAKRA AA L L R V AA G SHDE P SAW PGLAHF L EH L LFLG GERFQGDDRLMPWVQRQG G QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 107 DH T NYH F DVKPDQ L PGA L D R FVQFFLS P QF T ESATE RE VCAVDS E HS nnlnnd L W R fl QVDRSRSK -------- P GH DYG 178
Cdd:TIGR02110 81 RT T AFF F ELPAAA L AAG L A R LCDMLAR P LL T AEDQQ RE REVLEA E YI ------ A W Q -- NDADTLRE aalldalq A GH PLR 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 179 K F GT G NKQT L LEDAR kkgi EPRD AL LQ FH KKW Y SSDI M TCCIV G KEP L NV LE SYLGTLEFDAIENKKVERKVWEEF - PYG 257
Cdd:TIGR02110 153 R F HA G SRDS L ALPNT ---- AFQQ AL RD FH RRH Y QAGN M QLWLQ G PQS L DE LE QLAARFGASLAAGGECAQAPPAPL l RFD 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 258 PDQ LA KRI dvvpik DT RL V s IS F PFPD L NGE f LSQPGHYISHLIGH E G PG S LL SE L KRL G WVS S LQSDSHT Q A AG FGVYN 337
Cdd:TIGR02110 229 RLT LA GGS ------ EP RL W - LL F ALAG L PAT - ARDNVTLLCEFLQD E A PG G LL AQ L RER G LAE S VAATWLY Q D AG QALLA 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 338 VTMDLSTEGLEHVDE I I QL MFNYI G M L QS - AGPK Q WV H -------------- DE LA E L SAVKFR F KDKEQPMTMAINVA A 402
Cdd:TIGR02110 301 LEFSARCISAAAAQQ I E QL LTQWL G A L AE q TWAE Q LE H yaqlaqrrfqtlal SP LA Q L RGRALG F ALGCALPDALTDFL A 380
410
....*....|.
gi 373219410 403 S LQ YI P FEHI L 413
Cdd:TIGR02110 381 A LQ DC P RTRL L 391
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
200-377
1.20e-29
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 116.34
E-value: 1.20e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 200 R DA L LQ F H KK W YS S D I M TCC IVG KEP ---- L NVL E S Y L G T L EF daie NK K VE rkv WEEF P YG P DQ L AK R ID VVP I KD TRL 275
Cdd:pfam05193 4 R ED L RD F Y KK H YS P D N M VLV IVG DVD heel L DLA E K Y F G D L PA ---- SP K GK --- PRPP P LE P AK L KG R EV VVP K KD EPQ 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 276 -- VSIS FP F P D LN GEFL S QPGHYISH L I G HEGPGS L LS EL K - RL G WVS S LQ S d SHTQAAGF G VYNVTMDLST egl E H VDE 352
Cdd:pfam05193 77 ah LALA FP G P P LN NDED S LALDVLNE L L G GGMSSR L FQ EL R e KE G LAY S VS S - FNDSYSDS G LFGIYATVDP --- E N VDE 152
170 180
....*....|....*....|....*
gi 373219410 353 I I Q L MFNYIGM L QSA G PKQWVHDEL 377
Cdd:pfam05193 153 V I E L ILEELEK L AQE G VTEEELERA 177
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
688-872
7.37e-19
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 85.14
E-value: 7.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 688 S V T L ED VQG F A K EMLQAFH M E L FVH G NSTEK E AIQ L SKELMDV L KSAAPNSRP lyrneh N P RR E LQLNN G D E Y V YRHLQK 767
Cdd:pfam05193 1 S L T R ED LRD F Y K KHYSPDN M V L VIV G DVDHE E LLD L AEKYFGD L PASPKGKPR ------ P P PL E PAKLK G R E V V VPKKDE 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 373219410 768 th DVGCVEVTYQI - GVQ N TY D NAVVGLIDQ L IREPA ---- F NT LR TN E A L G Y I V WTGSRLNCGTVALNVIVQG pk SVDH V 842
Cdd:pfam05193 75 -- PQAHLALAFPG p PLN N DE D SLALDVLNE L LGGGM ssrl F QE LR EK E G L A Y S V SSFNDSYSDSGLFGIYATV -- DPEN V 150
170 180 190
....*....|....*....|....*....|.
gi 373219410 843 L E R IE VF LE SVR K EIA E - MPQ EE FDNQVSGM 872
Cdd:pfam05193 151 D E V IE LI LE ELE K LAQ E g VTE EE LERAKNQL 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
