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Conserved domains on  [gi|351050847|emb|CCD65460|]
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G-protein coupled receptor str-33 [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 9-316 1.60e-102

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 303.61  E-value: 1.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847    9 SRTIAEFAFLTALVCNSLLIYLTARRTKNITGAYKYMIILFALLGLIFSCTEMLARPFVHNFNASFVYFSLSNDLSEFKS 88
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847   89 LVQMLLVLYSGLYSSLISFVAVQFIYRYMVLVNANLLEsWFTGWKLVFWVFYVIFFGFAWSASVYFCLFPDTYSYNYIRT 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLK-YFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLRE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847  169 EFKDVYNIGVDRVAIFILVAYEKhPSSEEYKLRPASVIMIAGTISILVIQYSIMLFCGASMHRQMNEKLKNFSPDNQRLQ 248
Cdd:pfam10326 160 ELLENYNLDIDEVAYVGPVYYPT-DENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 351050847  249 KQFFKTLLLQISVPTVLFHMPIFPVLLGPFFNFEISAESGIIYSLFSLYPPIDGLIIMTVVTDYRIAL 316
Cdd:pfam10326 239 KQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 9-316 1.60e-102

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 303.61  E-value: 1.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847    9 SRTIAEFAFLTALVCNSLLIYLTARRTKNITGAYKYMIILFALLGLIFSCTEMLARPFVHNFNASFVYFSLSNDLSEFKS 88
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847   89 LVQMLLVLYSGLYSSLISFVAVQFIYRYMVLVNANLLEsWFTGWKLVFWVFYVIFFGFAWSASVYFCLFPDTYSYNYIRT 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLK-YFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLRE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847  169 EFKDVYNIGVDRVAIFILVAYEKhPSSEEYKLRPASVIMIAGTISILVIQYSIMLFCGASMHRQMNEKLKNFSPDNQRLQ 248
Cdd:pfam10326 160 ELLENYNLDIDEVAYVGPVYYPT-DENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 351050847  249 KQFFKTLLLQISVPTVLFHMPIFPVLLGPFFNFEISAESGIIYSLFSLYPPIDGLIIMTVVTDYRIAL 316
Cdd:pfam10326 239 KQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 9-316 1.60e-102

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 303.61  E-value: 1.60e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847    9 SRTIAEFAFLTALVCNSLLIYLTARRTKNITGAYKYMIILFALLGLIFSCTEMLARPFVHNFNASFVYFSLSNDLSEFKS 88
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847   89 LVQMLLVLYSGLYSSLISFVAVQFIYRYMVLVNANLLEsWFTGWKLVFWVFYVIFFGFAWSASVYFCLFPDTYSYNYIRT 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLK-YFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLRE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847  169 EFKDVYNIGVDRVAIFILVAYEKhPSSEEYKLRPASVIMIAGTISILVIQYSIMLFCGASMHRQMNEKLKNFSPDNQRLQ 248
Cdd:pfam10326 160 ELLENYNLDIDEVAYVGPVYYPT-DENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQ 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 351050847  249 KQFFKTLLLQISVPTVLFHMPIFPVLLGPFFNFEISAESGIIYSLFSLYPPIDGLIIMTVVTDYRIAL 316
Cdd:pfam10326 239 KQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 20-313 2.06e-37

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 136.22  E-value: 2.06e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847   20 ALVCNSLLIYLTARRTKNITGAYKYMIILFALLGLIFSCTEMLARPFVHNFNASFVYFSLSNDLSEFKSLVQMLLVLYSG 99
Cdd:pfam10319  18 SFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELGQHALSARCS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847  100 LYSSLISFVAVQFIYRYMVLVNANLLESWFTGWKLVFWVFYVIFFGFAWSASVYFCLFPDTYSYNYIRTEFKDVYNIGVD 179
Cdd:pfam10319  98 FISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGVDSM 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847  180 RVAIFILVAYEkhpSSEEYKLRPASVIMIAGTISILVIqySIMLFCGASMHRQMNEKLKNFSPDNQRLQKQFFKTLLLQI 259
Cdd:pfam10319 178 DINMLGALYWE---ASDETVFRSWLGILLLTVISVYSI--ILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQT 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 351050847  260 SVPTVLFHMPIFPVLLGPFFNFEISaeSGIIY---SLFSLYPPIDGLIIMTVVTDYR 313
Cdd:pfam10319 253 IIPICISFSPCVLAWYSPIFGIDLG--RWNNYlevIALSAFPFIDPLAIILCLPVYR 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 17-313 1.07e-06

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 49.47  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847   17 FLTALVCNSLLIYLTARRTKNITGAYKYMIILFALLGLIFSCTEMLA--RPFVHNFNASFVYFSLSNDLSEFKSLVQMLL 94
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTqqRIIPNGVSMALISYGPCKYFGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847   95 VLYSGLYSSLISFVAvqFIYRYMVLVNANlleswFTGWKLVFWVFYVIFFGFAWSASVYFclfpdtysynyIRTEFKDVY 174
Cdd:pfam10317  89 LQHFLLHSGWSLLLT--FYYRYYILKHVD-----PKRKKLILLIIIHYIPSLSQLIVIFL-----------SPTDFLPVE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847  175 NIGVDRVAIFILVAYEKHPSSEEYKLrPASVIMIAGTISILVIqYSIMLFCGASMHRQMNEKLKNFSPDNQRLQKQFFKT 254
Cdd:pfam10317 151 ALTKELHPNYNLTDYTVTGFSDLQSF-PALINTLIMTIPVFPI-PIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKG 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 351050847  255 LLLQISVPTVLFHMPIFPVLLGPFFNFEISAESGIIYSLFSLYPPIDGLIIMTVVTDYR 313
Cdd:pfam10317 229 LTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYR 287
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 89-320 1.69e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 42.92  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847   89 LVQMLLVLYSGLYSSLISFvavqFIYRYMVLVNANLLESWftGWKLVFWVFYVIFFGFAWSASVYFcLFPD-TYSYNYIR 167
Cdd:pfam10318  88 QFYIGVTSLALVGVSIILL----FENRYSILFTNKKRITW--KKTRVLYLIFNYIIALLFLIPIYL-NIPDqEAAKLKVL 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050847  168 TEFKDVYNIGVDRVAIFILvayekhpsSEEYKLrpaSVIMIAGTISILVIQysiMLFCGASMHRQMNEKLKNF-SPDNQR 246
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVL--------AIDSTY---FLICIVLLILILIIQ---ILFFVFLTIYYLFKSVKSSlSKKTRK 226

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 351050847  247 LQKQFFKTLLLQISVPTVLFHMPIFPVLLGPFFNFEISAESGIIYSLFSLYPPIDGLIIMTVVTDYRIALTELF 320
Cdd:pfam10318 227 LQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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