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Conserved domains on  [gi|351050281|emb|CCD64823|]
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Arrestin C-terminal-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

arrestin family protein( domain architecture ID 10448464)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen); similar to Homo sapiens beta-arrestin-1 and arrestin domain-containing protein

CATH:  2.60.40.840
Gene Ontology:  GO:0005515
PubMed:  7720881|7833798|35563378
SCOP:  4007521

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 9-158 1.10e-64

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


:

Pssm-ID: 425619  Cd Length: 148  Bit Score: 204.83  E-value: 1.10e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281    9 VIFDQPDEVFFPGQPISGRVVLTTKENYKARAVNIKILGLAHTSWKNYENACkfNGSSISirpRSIHYSANVNYLDYTQL 88
Cdd:pfam00339   3 IEFDKPDGVYFPGETVTGRVLLENEEPKKARAVKIELRGKARTGWEESEVRK--EGLTFR---KDLYYKGTEVYLPTETS 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351050281   89 LWTC-EDGKNELAAGEYVWPFSYTLPTSIPPSFEGKYGYVRYTVKVEVDRPWRKDKAKKMCITVSPLLDLN 158
Cdd:pfam00339  78 LWGSkTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 183-327 2.46e-28

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


:

Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 108.97  E-value: 2.46e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281   183 GILEMSLNIPKTGFVPGETVPLNVHLINHSSTSVNNIKAQMLQQCKFTGYKSGATynyggdfernEKMSDKIQRIKFDTK 262
Cdd:smart01017   3 GPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVSSDGPVK----------RSLAEKSKEKKADRK 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281   263 KVVKVCQKLEVPAKNEHKFVLELRIPSVTPTInQFSPVITVEYILQVNVD-----GLVRCESSILLGSVP 327
Cdd:smart01017  73 TLVKELDGGPVLPGNKDKFEGQLKVPPLPPTS-RTCRLIKVEYKLKVKLRlsgkhSELRLELPITIGTVP 141
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 9-158 1.10e-64

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 204.83  E-value: 1.10e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281    9 VIFDQPDEVFFPGQPISGRVVLTTKENYKARAVNIKILGLAHTSWKNYENACkfNGSSISirpRSIHYSANVNYLDYTQL 88
Cdd:pfam00339   3 IEFDKPDGVYFPGETVTGRVLLENEEPKKARAVKIELRGKARTGWEESEVRK--EGLTFR---KDLYYKGTEVYLPTETS 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351050281   89 LWTC-EDGKNELAAGEYVWPFSYTLPTSIPPSFEGKYGYVRYTVKVEVDRPWRKDKAKKMCITVSPLLDLN 158
Cdd:pfam00339  78 LWGSkTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 183-327 2.46e-28

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 108.97  E-value: 2.46e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281   183 GILEMSLNIPKTGFVPGETVPLNVHLINHSSTSVNNIKAQMLQQCKFTGYKSGATynyggdfernEKMSDKIQRIKFDTK 262
Cdd:smart01017   3 GPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVSSDGPVK----------RSLAEKSKEKKADRK 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281   263 KVVKVCQKLEVPAKNEHKFVLELRIPSVTPTInQFSPVITVEYILQVNVD-----GLVRCESSILLGSVP 327
Cdd:smart01017  73 TLVKELDGGPVLPGNKDKFEGQLKVPPLPPTS-RTCRLIKVEYKLKVKLRlsgkhSELRLELPITIGTVP 141
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 183-328 3.29e-22

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 92.00  E-value: 3.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281  183 GILEMSLNIPKTGFVPGETVPLNVHLINHSSTSVNNIKAQMLQQCKFtgyksgatynyggdferneKMSDKIQRIKFDTK 262
Cdd:pfam02752   3 GKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTY-------------------KAKTPLGESKREER 63

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 351050281  263 KVVKV-CQKLEVPAKNEHKFVLELRIP-SVTPTINQfSPVITVEYILQVNVD-----GLVRCESSILLGSVPI 328
Cdd:pfam02752  64 VVAKEkNPGVAPGSKDKWEKELQLQIPtDLPPSSTK-CKIIKVEYKLKVTVDlsgsaSELRLELPITIGTSPL 135
ART10-like cd22952
Arrestin-related trafficking adapter 10 and similar proteins; Arrestin-related trafficking ...
 7-138 7.87e-04

Arrestin-related trafficking adapter 10 and similar proteins; Arrestin-related trafficking adaptors (ARTs) function by targeting specific plasma membrane proteins to the endocytic system. They contain multiple PY motifs that are required for recruitment of Rsp5/Nedd4-like ubiquitin ligase which modifies the cargoes. It has been proposed that ARTs remodel the cell surface in response to environmental cues and may serve as part of a quality-control system at the plasma membrane, targeting damaged and misfolded membrane proteins for ubiquitination and subsequent degradation in the lysosome/vacuole. The specific target protein for ART10 is not yet known.


Pssm-ID: 438568 [Multi-domain]  Cd Length: 409  Bit Score: 41.58  E-value: 7.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281   7 LKVIFDQPDEVFFPGQPISGRVVLTTKENYKARAVNIKILGLAHTSWKNYENackfNGSSISIRPRSIHYSANVnyLDYT 86
Cdd:cd22952    2 VRILLDDNGEFYTNLDVISGRVILKLTKSESISAIVVKLEGESRTRLKVPKG----NYNGQNDRGRTATEVHKL--LYKV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281  87 QLLW----TCEDGKNE---LAAGEYVWPFSYTLP----------------------------------TSIPPSFEGKYG 125
Cdd:cd22952   76 QQVFpppnVRSVSSSKsftLTPGEYEYPFEFKIPfnnscsdphskstsgglggslmdglppsfnrhvkKTLPPSLTGFPG 155

                        170
                 ....*....|....*
gi 351050281 126 Y--VRYTVKVEVDRP 138
Cdd:cd22952  156 EaeIRYYVKVTVQRP 170
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 9-158 1.10e-64

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 204.83  E-value: 1.10e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281    9 VIFDQPDEVFFPGQPISGRVVLTTKENYKARAVNIKILGLAHTSWKNYENACkfNGSSISirpRSIHYSANVNYLDYTQL 88
Cdd:pfam00339   3 IEFDKPDGVYFPGETVTGRVLLENEEPKKARAVKIELRGKARTGWEESEVRK--EGLTFR---KDLYYKGTEVYLPTETS 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 351050281   89 LWTC-EDGKNELAAGEYVWPFSYTLPTSIPPSFEGKYGYVRYTVKVEVDRPWRKDKAKKMCITVSPLLDLN 158
Cdd:pfam00339  78 LWGSkTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 183-327 2.46e-28

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 108.97  E-value: 2.46e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281   183 GILEMSLNIPKTGFVPGETVPLNVHLINHSSTSVNNIKAQMLQQCKFTGYKSGATynyggdfernEKMSDKIQRIKFDTK 262
Cdd:smart01017   3 GPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVSSDGPVK----------RSLAEKSKEKKADRK 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281   263 KVVKVCQKLEVPAKNEHKFVLELRIPSVTPTInQFSPVITVEYILQVNVD-----GLVRCESSILLGSVP 327
Cdd:smart01017  73 TLVKELDGGPVLPGNKDKFEGQLKVPPLPPTS-RTCRLIKVEYKLKVKLRlsgkhSELRLELPITIGTVP 141
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 183-328 3.29e-22

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 92.00  E-value: 3.29e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281  183 GILEMSLNIPKTGFVPGETVPLNVHLINHSSTSVNNIKAQMLQQCKFtgyksgatynyggdferneKMSDKIQRIKFDTK 262
Cdd:pfam02752   3 GKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTY-------------------KAKTPLGESKREER 63

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 351050281  263 KVVKV-CQKLEVPAKNEHKFVLELRIP-SVTPTINQfSPVITVEYILQVNVD-----GLVRCESSILLGSVPI 328
Cdd:pfam02752  64 VVAKEkNPGVAPGSKDKWEKELQLQIPtDLPPSSTK-CKIIKVEYKLKVTVDlsgsaSELRLELPITIGTSPL 135
ART10-like cd22952
Arrestin-related trafficking adapter 10 and similar proteins; Arrestin-related trafficking ...
 7-138 7.87e-04

Arrestin-related trafficking adapter 10 and similar proteins; Arrestin-related trafficking adaptors (ARTs) function by targeting specific plasma membrane proteins to the endocytic system. They contain multiple PY motifs that are required for recruitment of Rsp5/Nedd4-like ubiquitin ligase which modifies the cargoes. It has been proposed that ARTs remodel the cell surface in response to environmental cues and may serve as part of a quality-control system at the plasma membrane, targeting damaged and misfolded membrane proteins for ubiquitination and subsequent degradation in the lysosome/vacuole. The specific target protein for ART10 is not yet known.


Pssm-ID: 438568 [Multi-domain]  Cd Length: 409  Bit Score: 41.58  E-value: 7.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281   7 LKVIFDQPDEVFFPGQPISGRVVLTTKENYKARAVNIKILGLAHTSWKNYENackfNGSSISIRPRSIHYSANVnyLDYT 86
Cdd:cd22952    2 VRILLDDNGEFYTNLDVISGRVILKLTKSESISAIVVKLEGESRTRLKVPKG----NYNGQNDRGRTATEVHKL--LYKV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 351050281  87 QLLW----TCEDGKNE---LAAGEYVWPFSYTLP----------------------------------TSIPPSFEGKYG 125
Cdd:cd22952   76 QQVFpppnVRSVSSSKsftLTPGEYEYPFEFKIPfnnscsdphskstsgglggslmdglppsfnrhvkKTLPPSLTGFPG 155

                        170
                 ....*....|....*
gi 351050281 126 Y--VRYTVKVEVDRP 138
Cdd:cd22952  156 EaeIRYYVKVTVQRP 170
LDB19 pfam13002
Arrestin_N terminal like; This is a family of proteins related to the Arrestin_N terminal ...
 90-129 3.62e-03

Arrestin_N terminal like; This is a family of proteins related to the Arrestin_N terminal family.


Pssm-ID: 404030  Cd Length: 183  Bit Score: 38.31  E-value: 3.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 351050281   90 WTCEDGKNELAAGEYVWPFSYTLPTSIPPSFEGKYGYVRY 129
Cdd:pfam13002  32 WDIQKNTTDLSVGSHSYPFSYLFPGSLPASTSNSETQVKY 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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