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Conserved domains on  [gi|351020596|emb|CCD62569|]
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Uncharacterized protein CELE_C06E1.9 [Caenorhabditis elegans]

Protein Classification

ASCC2 family CUE domain-containing protein( domain architecture ID 10198858)

ASCC2 family CUE domain-containing protein similar to human activating signal cointegrator 1 complex subunit 2 (ASCC2) that plays a role in DNA damage repair as component of the ASCC complex

CATH:  1.10.8.10
Gene Ontology:  GO:0043130
PubMed:  12628920|12787494
SCOP:  4003786

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
336-373 4.84e-10

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


:

Pssm-ID: 270547  Cd Length: 40  Bit Score: 55.06  E-value: 4.84e-10
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 351020596 336 RAQIASIREILPHFSAEFVHLALRHFSYDSEVTLASLL 373
Cdd:cd14364    1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALL 38
 
Name Accession Description Interval E-value
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
336-373 4.84e-10

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


Pssm-ID: 270547  Cd Length: 40  Bit Score: 55.06  E-value: 4.84e-10
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 351020596 336 RAQIASIREILPHFSAEFVHLALRHFSYDSEVTLASLL 373
Cdd:cd14364    1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALL 38
 
Name Accession Description Interval E-value
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
336-373 4.84e-10

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


Pssm-ID: 270547  Cd Length: 40  Bit Score: 55.06  E-value: 4.84e-10
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 351020596 336 RAQIASIREILPHFSAEFVHLALRHFSYDSEVTLASLL 373
Cdd:cd14364    1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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