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Conserved domains on  [gi|311823559|emb|CBX86384|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 11145292)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins; similar to phosphatidylinositol transfer proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
127-288 3.78e-39

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 137.82  E-value: 3.78e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559   127 DLEGKVAYM---RGYDKEGHPVCYNAYGVFKEKEMyervfgdeeKLNKFLRWRVQVLERGVKmLHFKPGGVNSIIQVTDL 203
Cdd:smart00516   1 ELELLKAYIpggRGYDKDGRPVLIERAGRFDLKSV---------TLEELLRYLVYVLEKILQ-EEKKTGGIEGFTVIFDL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559   204 KDMPKRELRVASNQ-ILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSKeGNAAETLYKFIRPEDI 282
Cdd:smart00516  71 KGLSMSNPDLSVLRkILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVG-NDSKEELLEYIDKEQL 149

                   ....*.
gi 311823559   283 PVQYGG 288
Cdd:smart00516 150 PEELGG 155
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
52-105 3.66e-07

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


:

Pssm-ID: 461043  Cd Length: 53  Bit Score: 46.50  E-value: 3.66e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 311823559   52 LQELKEKL--SASSSKASSMWgvslLGGDDKADVILLKFLRARDFKVADSLRMLEK 105
Cdd:pfam03765   2 YDELLELLkdEDEETDREKFW----LTREDHDDVCLLRFLRARKWDVEKAIKMLED 53
 
Name Accession Description Interval E-value
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
127-288 3.78e-39

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 137.82  E-value: 3.78e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559   127 DLEGKVAYM---RGYDKEGHPVCYNAYGVFKEKEMyervfgdeeKLNKFLRWRVQVLERGVKmLHFKPGGVNSIIQVTDL 203
Cdd:smart00516   1 ELELLKAYIpggRGYDKDGRPVLIERAGRFDLKSV---------TLEELLRYLVYVLEKILQ-EEKKTGGIEGFTVIFDL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559   204 KDMPKRELRVASNQ-ILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSKeGNAAETLYKFIRPEDI 282
Cdd:smart00516  71 KGLSMSNPDLSVLRkILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVG-NDSKEELLEYIDKEQL 149

                   ....*.
gi 311823559   283 PVQYGG 288
Cdd:smart00516 150 PEELGG 155
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
125-289 5.97e-33

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 121.29  E-value: 5.97e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559 125 FKDLEGKVAYMRGYDKEGHPVCYNAYGVFKEKEMyervfgdeeKLNKFLRWRVQVLERGVKMLHFkpgGVNSIIQVTDLK 204
Cdd:cd00170    4 LLELLGGIGYLGGRDKEGRPVLVFRAGWDPPKLL---------DLEELLRYLVYLLEKALRELEE---QVEGFVVIIDLK 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559 205 DMPKRELRVAS--NQILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSkeGNAAETLYKFIRPEDI 282
Cdd:cd00170   72 GFSLSNLSDLSllKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFL--GSDLEELLEYIDPDQL 149

                 ....*..
gi 311823559 283 PVQYGGL 289
Cdd:cd00170  150 PKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
130-288 8.59e-30

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 112.74  E-value: 8.59e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559  130 GKVAYMRGYDKEGHPVCYNAYGVFKEKEMyervfgDEEKLNKFLRWrvqVLERGVKMLHfkPGGVNSIIQVTDLKD---- 205
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKS------SEEELVRFLVL---VLERALLLMP--EGQVEGLTVIIDLKGlsls 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559  206 -MPKRELRVAsNQILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSKEGNaAETLYKFIRPEDIPV 284
Cdd:pfam00650  70 nMDWWSISLL-KKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSN-EEELEKYIPPEQLPK 147

                  ....
gi 311823559  285 QYGG 288
Cdd:pfam00650 148 EYGG 151
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
52-105 3.66e-07

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 46.50  E-value: 3.66e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 311823559   52 LQELKEKL--SASSSKASSMWgvslLGGDDKADVILLKFLRARDFKVADSLRMLEK 105
Cdd:pfam03765   2 YDELLELLkdEDEETDREKFW----LTREDHDDVCLLRFLRARKWDVEKAIKMLED 53
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
82-106 9.38e-06

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 42.54  E-value: 9.38e-06
                           10        20
                   ....*....|....*....|....*
gi 311823559    82 DVILLKFLRARDFKVADSLRMLEKC 106
Cdd:smart01100  24 DAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
127-288 3.78e-39

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 137.82  E-value: 3.78e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559   127 DLEGKVAYM---RGYDKEGHPVCYNAYGVFKEKEMyervfgdeeKLNKFLRWRVQVLERGVKmLHFKPGGVNSIIQVTDL 203
Cdd:smart00516   1 ELELLKAYIpggRGYDKDGRPVLIERAGRFDLKSV---------TLEELLRYLVYVLEKILQ-EEKKTGGIEGFTVIFDL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559   204 KDMPKRELRVASNQ-ILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSKeGNAAETLYKFIRPEDI 282
Cdd:smart00516  71 KGLSMSNPDLSVLRkILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVG-NDSKEELLEYIDKEQL 149

                   ....*.
gi 311823559   283 PVQYGG 288
Cdd:smart00516 150 PEELGG 155
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
125-289 5.97e-33

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 121.29  E-value: 5.97e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559 125 FKDLEGKVAYMRGYDKEGHPVCYNAYGVFKEKEMyervfgdeeKLNKFLRWRVQVLERGVKMLHFkpgGVNSIIQVTDLK 204
Cdd:cd00170    4 LLELLGGIGYLGGRDKEGRPVLVFRAGWDPPKLL---------DLEELLRYLVYLLEKALRELEE---QVEGFVVIIDLK 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559 205 DMPKRELRVAS--NQILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSkeGNAAETLYKFIRPEDI 282
Cdd:cd00170   72 GFSLSNLSDLSllKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFL--GSDLEELLEYIDPDQL 149

                 ....*..
gi 311823559 283 PVQYGGL 289
Cdd:cd00170  150 PKELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
130-288 8.59e-30

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 112.74  E-value: 8.59e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559  130 GKVAYMRGYDKEGHPVCYNAYGVFKEKEMyervfgDEEKLNKFLRWrvqVLERGVKMLHfkPGGVNSIIQVTDLKD---- 205
Cdd:pfam00650   1 GGKVYLHGRDKEGRPVLYLRLGRHDPKKS------SEEELVRFLVL---VLERALLLMP--EGQVEGLTVIIDLKGlsls 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311823559  206 -MPKRELRVAsNQILSLFQDNYPELVATKIFINVPWYFSVIYSMFSPFLTQRTKSKFVMSKEGNaAETLYKFIRPEDIPV 284
Cdd:pfam00650  70 nMDWWSISLL-KKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSN-EEELEKYIPPEQLPK 147

                  ....
gi 311823559  285 QYGG 288
Cdd:pfam00650 148 EYGG 151
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
52-105 3.66e-07

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 46.50  E-value: 3.66e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 311823559   52 LQELKEKL--SASSSKASSMWgvslLGGDDKADVILLKFLRARDFKVADSLRMLEK 105
Cdd:pfam03765   2 YDELLELLkdEDEETDREKFW----LTREDHDDVCLLRFLRARKWDVEKAIKMLED 53
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
82-106 9.38e-06

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 42.54  E-value: 9.38e-06
                           10        20
                   ....*....|....*....|....*
gi 311823559    82 DVILLKFLRARDFKVADSLRMLEKC 106
Cdd:smart01100  24 DAFLLRFLRARKFDVEKAKEMLEKY 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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