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Conserved domains on  [gi|300570895|emb|CBV17343|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

Bax inhibitor 1 family protein( domain architecture ID 1847)

Bax inhibitor 1 family protein similar to Saccharomyces cerevisiae Bax inhibitor 1 that links the unfolded protein response and programmed cell death, and mediates mitochondrial-dependent apoptosis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BI-1-like super family cl00473
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
31-247 5.39e-79

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


The actual alignment was detected with superfamily member cd10429:

Pssm-ID: 469783  Cd Length: 233  Bit Score: 237.50  E-value: 5.39e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  31 NPELRWGFIRKVYSIIAFQLLATVAVAATVVTVRPIALFFATTglgLALYIVIIITPLIVLCPLYYYHQKHPVNYLLLGI 110
Cdd:cd10429   23 EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSH---PWLFLISLIGSLILLIALYWKRHSHPVNLILLSL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 111 FTLALAFVVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAARKGYDFnflGPFLFGALTVLIFFALIQILFPLGRVSV 190
Cdd:cd10429  100 FTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSF---GALLFILLWALILLALIFQFFPYSPTFE 176
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 300570895 191 MIYGCLVSIIFCGYIVYDTDNLIKRHTYDEYIWAAVSLYLDIINLFLYLLTVLRALQ 247
Cdd:cd10429  177 LVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
31-247 5.39e-79

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 237.50  E-value: 5.39e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  31 NPELRWGFIRKVYSIIAFQLLATVAVAATVVTVRPIALFFATTglgLALYIVIIITPLIVLCPLYYYHQKHPVNYLLLGI 110
Cdd:cd10429   23 EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSH---PWLFLISLIGSLILLIALYWKRHSHPVNLILLSL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 111 FTLALAFVVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAARKGYDFnflGPFLFGALTVLIFFALIQILFPLGRVSV 190
Cdd:cd10429  100 FTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSF---GALLFILLWALILLALIFQFFPYSPTFE 176
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 300570895 191 MIYGCLVSIIFCGYIVYDTDNLIKRHTYDEYIWAAVSLYLDIINLFLYLLTVLRALQ 247
Cdd:cd10429  177 LVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
36-243 9.66e-35

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 123.44  E-value: 9.66e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895   36 WGFIRKVYSIIAFQLLATVAVAATVVTVRPIALFFATTGLGLALYIVIIITPLIVLCPLYYYHQKHPVNYLLLGIFTLAL 115
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  116 AFVVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAarkGYDFNFLGPFLFGALTVLIFFALIQILFPlGRVSVMIYGC 195
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTT---KRDLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAISY 156
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 300570895  196 LVSIIFCGYIVYDTDNLIKRH-TYDEY--IWAAVSLYLDIINLFLYLLTVL 243
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYgEYGDYdaILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
38-240 2.75e-18

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 80.61  E-value: 2.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  38 FIRKVYSIIAFQLLATVAVAATVVTVRPIALFFATTGLglaLYIVIIITPLIVLCPLYYYHQKH--PVNYLLLGIFT--- 112
Cdd:COG0670   22 VLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPG---LFWVLLIAPLGLVFLLSKLANRAnsAAALALLFAYTalm 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 113 -LALAFVVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAARkgyDFNFLGPFLFGALTVLIFFALIQILFPLGRVSVM 191
Cdd:COG0670   99 gLTLSPILLVYTGLSGPASIAQAFGGTAATFGGLSLYGYTTKR---DLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLA 175
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 300570895 192 IyGCLVSIIFCGYIVYDTDNLIKRH-TYDEYIWAAVSLYLDIINLFLYLL 240
Cdd:COG0670  176 I-SVAGVLLFSGLTLYDTQRIKHGYeTNKQYIMAALSLYLDFINLFLSLL 224
 
Name Accession Description Interval E-value
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
31-247 5.39e-79

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 237.50  E-value: 5.39e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  31 NPELRWGFIRKVYSIIAFQLLATVAVAATVVTVRPIALFFATTglgLALYIVIIITPLIVLCPLYYYHQKHPVNYLLLGI 110
Cdd:cd10429   23 EPEIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSH---PWLFLISLIGSLILLIALYWKRHSHPVNLILLSL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 111 FTLALAFVVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAARKGYDFnflGPFLFGALTVLIFFALIQILFPLGRVSV 190
Cdd:cd10429  100 FTLCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSF---GALLFILLWALILLALIFQFFPYSPTFE 176
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 300570895 191 MIYGCLVSIIFCGYIVYDTDNLIKRHTYDEYIWAAVSLYLDIINLFLYLLTVLRALQ 247
Cdd:cd10429  177 LVYAGLGALLFSGYIVYDTQLIMKRLSPDEYILAAISLYLDIINLFLSILRILAAMN 233
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
30-243 2.09e-36

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 128.04  E-value: 2.09e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  30 ENPELRWGFIRKVYSIIAFQLLATVAVAATVVTVRPIALFF-ATTGLGLALYIVIIITpLIVLCPLYYYHQKHPVNYLLL 108
Cdd:cd10428    3 DDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVrKNPWLYYVSYIVFFIT-YIALACCEGLRRRFPWNLILL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 109 GIFTLALAFVVGLTCAFTNGKVILESVILTSVVVLSLTLYtfwAARKGYDFNFLGPFLFGALTVLIFFALIQILFPlGRV 188
Cdd:cd10428   82 GIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLF---AFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFY-VKW 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 300570895 189 SVMIYGCLVSIIFCGYIVYDTDNLIKRHTY----DEYIWAAVSLYLDIINLFLYLLTVL 243
Cdd:cd10428  158 LHIVYASLGALLFSLYLAVDTQLLMGGRKYelspEEYIFAALNIYVDIVNIFLYILQLI 216
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
36-243 9.66e-35

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 123.44  E-value: 9.66e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895   36 WGFIRKVYSIIAFQLLATVAVAATVVTVRPIALFFATTGLGLALYIVIIITPLIVLCPLYYYHQKHPVNYLLLGIFTLAL 115
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYSSNVALLLLLAFTLLM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  116 AFVVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAarkGYDFNFLGPFLFGALTVLIFFALIQILFPlGRVSVMIYGC 195
Cdd:pfam01027  81 GLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTT---KRDLSFLGGFLFAGLIGLIVASLVNIFLP-SSALSLAISY 156
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 300570895  196 LVSIIFCGYIVYDTDNLIKRH-TYDEY--IWAAVSLYLDIINLFLYLLTVL 243
Cdd:pfam01027 157 LGVLLFSGFILYDTQRIIKRYgEYGDYdaILAALSLYLDFINLFLSLLRIL 207
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
38-243 5.32e-20

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 84.77  E-value: 5.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  38 FIRKVYSIIAFQLLATVAVAATVvtvrpiaLFFATTGLGLALYIVIIITPLIVLCPLYYYHQKHPVNYLLLGIFTLALAF 117
Cdd:cd06181    5 FLRKVYMILALQLLLTAATATAF-------TVCDPGWYWSPALMGLLTSMLALMATAAMIRAKMPVNLILLFGFTGLMGY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 118 VVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAARkgyDFNFLGPFLFGALTVLIFFALIQILFPL-GRVSVMIYGCL 196
Cdd:cd06181   78 VVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARK---DFLFLGGPLMAGLGFLLLSFLLNTFFYSpWLHLVAAAVGL 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 300570895 197 VsiIFCGYIVYDTDNLIKR--HTYDEYIWAAVSLYLDIINLFLYLLTVL 243
Cdd:cd06181  155 V--LFCGFLLYDTQLIIHKaeVGPEDYINACISLYLDIINIFIRLLTIL 201
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
38-240 2.48e-18

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 80.30  E-value: 2.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  38 FIRKVYSIIAFQLLATVAVAATVVTVRPIALFFATtglglALYIVIIITPLIVLCPLYY--YHQKHPVNYLLLGIFTLAL 115
Cdd:cd10432    5 FMKKVYGLMAAGLLLTAVGAYVGASTPALLLIAGS-----PLMWVLLIAELALVFGLSFriNKMSVATALPLFFAFAALT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 116 AFVVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAARkgyDFNFLGPFLFGALTVLIFFALIQILFPLGRVSvMIYGC 195
Cdd:cd10432   80 GLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKK---DLSFLGSFLFMGLIGLIIASLVNIFLQSSALQ-FAISA 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 300570895 196 LVSIIFCGYIVYDTDNLIKRH-------TYDEYIWAAVSLYLDIINLFLYLL 240
Cdd:cd10432  156 IGVLIFSGLIAYDTQRIKRMYeagggesGYKDAIMGALSLYLDFINLFLFLL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
38-240 2.75e-18

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 80.61  E-value: 2.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  38 FIRKVYSIIAFQLLATVAVAATVVTVRPIALFFATTGLglaLYIVIIITPLIVLCPLYYYHQKH--PVNYLLLGIFT--- 112
Cdd:COG0670   22 VLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPG---LFWVLLIAPLGLVFLLSKLANRAnsAAALALLFAYTalm 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 113 -LALAFVVGLTCAFTNGKVILESVILTSVVVLSLTLYTFWAARkgyDFNFLGPFLFGALTVLIFFALIQILFPLGRVSVM 191
Cdd:COG0670   99 gLTLSPILLVYTGLSGPASIAQAFGGTAATFGGLSLYGYTTKR---DLSFLGSFLFMGLIGLIIASLVNIFLQSPALSLA 175
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 300570895 192 IyGCLVSIIFCGYIVYDTDNLIKRH-TYDEYIWAAVSLYLDIINLFLYLL 240
Cdd:COG0670  176 I-SVAGVLLFSGLTLYDTQRIKHGYeTNKQYIMAALSLYLDFINLFLSLL 224
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
110-246 3.60e-11

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 60.68  E-value: 3.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 110 IFTLALAFVVGLT--------CAFTNG-KVILESVILTSVVVLSLTLYTFWAARkgyDFNFLGPFLFGALTVLIFFALIQ 180
Cdd:cd10433   63 VLVFAFTGFMGYTlgpilnmyLALPNGgQIIMTALGGTAAIFFGLSAYALTTKK---DFSFLGGFLFVGAIVLLLAAVAN 139
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300570895 181 ILFPLGRVSVMIyGCLVSIIFCGYIVYDTDNLIKRHTyDEYIWAAVSLYLDIINLFLYLLTVLRAL 246
Cdd:cd10433  140 IFLQIPALSLAI-SAAFVLFSSGFILYDTSRIIHGGE-TNYIMATVSLYVSIYNLFVSLLNLLGAF 203
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
108-243 2.69e-08

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 52.61  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 108 LGIFtLALAFVVGLT-------CAFTNGKVILESVILTSVVVLSLTLYTFWAARKGYdfNFLGPFLFGALTVLIFFALIQ 180
Cdd:cd10430   68 LGLL-LGFAFLTGASlgplldlVIAINPSIIVTAFLGTAVIFACFSLAALLAKRREY--LYLGGLLSSALSILLLVSLAN 144
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300570895 181 ILF-PLGRVSVMIYGCLVsiIFCGYIVYDTDNLIKR--HTYDEYIWAAVSLYLDIINLFLYLLTVL 243
Cdd:cd10430  145 IFGgSKFLFQAELYLGLL--VFCGFVLFDTQMIIEKaeNGDRDYIWHALDLFVDFVALFRRLLIIL 208
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
90-243 8.11e-06

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 45.83  E-value: 8.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895  90 VLCPLYYYHQKHPVNYLLLGIFTLALAFVVGLTCaFTNGKVILESVILTSVVVLSLTlyTFWAARKGYDFNFLGPFLFGA 169
Cdd:cd10431   95 MLVRSYTYPENPGAKHLAWLGHSGVQGAVLAPLC-FLGGPLLIRAALYTAGIVGGLS--TVAACAPSEKFLYMGGPLAIG 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300570895 170 LTVLIFFALIQILFPLGRV------SVMIYGCLVsiIFCGYIVYDTDNLIKR---------HTYDEyIWAAVSLYLDIIN 234
Cdd:cd10431  172 LGVVFASSLGSMFLPPTTAlgaglySVSLYGGLV--LFGGFLLYDTQKIIKRaethplygvRKYDP-INASMSIYMDTIN 248

                 ....*....
gi 300570895 235 LFLYLLTVL 243
Cdd:cd10431  249 IFIRLVTIL 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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