|
Name |
Accession |
Description |
Interval |
E-value |
| Sin3 super family |
cl35027 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
13-672 |
8.28e-88 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
The actual alignment was detected with superfamily member COG5602:
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 311.47 E-value: 8.28e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 13 SQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVS-QKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRT 91
Cdd:COG5602 85 EDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPPRIPyRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAI 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 92 DTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEED----------------------------------------- 130
Cdd:COG5602 165 DTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQpngsrlhvttpqgplssppvqssyyvapcnhdqrtshptlp 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 131 ---------------DALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDL 195
Cdd:COG5602 245 sdsqpepsapshmpsDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDL 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 196 LEQFTRFLPASlpSHSAAQhSRSQAQQYSDRGSDPPLLHQMQVEKERRRERavalrgdysverydlnddktmvkiQREQR 275
Cdd:COG5602 325 LEEFKEFLPDS--SVSAEQ-STANAQKPSKRLPPIGSFSLPTAAPEQNRPS------------------------LLWES 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 276 KRLDKENRARRGRDLDDREagqdnlhhfpekrkssrraealEAYSGSASHSEKDNLKSMYKQAFvfcEKVKDRLCSQDDY 355
Cdd:COG5602 378 PRSISNISRYRADLLTSFS----------------------RNFVPIRIHMPISHLSNESEDFF---ERIKQYLKDKNLY 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 356 QTFLKCLNIFSNGIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESItdgfqrlagvmskklfssEEQLSRPMKveeke 435
Cdd:COG5602 433 HEFLKLLNLYSQKIIDKNDLVERLFAFLGSNEELIRWFKAFINYSEPE------------------KEPLRETRK----- 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 436 sehkpeleavketeqckkeymgksiqelDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSV-TSGSEDYSF 514
Cdd:COG5602 490 ----------------------------DLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHpTWASEDSGF 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 515 KHMRRNQYEESLFRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIER----LYG-DH 589
Cdd:COG5602 542 IAHRKNQYEEALFKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKvikkVYDkEH 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 590 GLDVIDILNKNPATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKEL 669
Cdd:COG5602 622 APEILEALLKKPHVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDR 701
|
...
gi 257675367 670 KEK 672
Cdd:COG5602 702 SQA 704
|
|
| Sin3a_C |
pfam16879 |
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ... |
1100-1343 |
4.81e-52 |
|
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.
:
Pssm-ID: 465294 Cd Length: 281 Bit Score: 184.73 E-value: 4.81e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1100 FYGNDDFYVLFRLHQILYERILYAKRNCS--GGELKSKN-------------------LKDTNAGDPYARFMRVLYGLLD 1158
Cdd:pfam16879 1 FFANTTIYVFFRLFQILYERLLKIKQAEEevAEEIKRRKankpakdlgliskeledfgLDLSDPEDYYPQLLELCERLID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1159 GSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYY-ENVRVLV-H 1236
Cdd:pfam16879 81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYrKQAEKLLgK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1237 EENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQ-------TELLSVSSGKKeeghdIVLQRNLTGL--- 1306
Cdd:pfam16879 161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSsyvlshpTEGVPRSKLRK-----PFLKRNLKAEree 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 257675367 1307 ---------YDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYF 1343
Cdd:pfam16879 236 eedeeeepkADAEEPEGPLEFESGLEIRICLNSYKLFYVPGTEDYF 281
|
|
| 2A1904 super family |
cl36772 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
931-1072 |
2.16e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
The actual alignment was detected with superfamily member TIGR00927:
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 42.68 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 931 LANGLRSDS-SKGTRNSDDPEGPSRNEKEEGELS-----PNGDFEDNFGVYKDHGVKSTSKPEN-SAEAEVEADAEVENE 1003
Cdd:TIGR00927 630 LSKGDVAEAeHTGERTGEEGERPTEAEGENGEESggeaeQEGETETKGENESEGEIPAERKGEQeGEGEIEAKEADHKGE 709
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257675367 1004 DDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1072
Cdd:TIGR00927 710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDE 778
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Sin3 |
COG5602 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
13-672 |
8.28e-88 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 311.47 E-value: 8.28e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 13 SQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVS-QKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRT 91
Cdd:COG5602 85 EDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPPRIPyRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAI 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 92 DTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEED----------------------------------------- 130
Cdd:COG5602 165 DTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQpngsrlhvttpqgplssppvqssyyvapcnhdqrtshptlp 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 131 ---------------DALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDL 195
Cdd:COG5602 245 sdsqpepsapshmpsDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDL 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 196 LEQFTRFLPASlpSHSAAQhSRSQAQQYSDRGSDPPLLHQMQVEKERRRERavalrgdysverydlnddktmvkiQREQR 275
Cdd:COG5602 325 LEEFKEFLPDS--SVSAEQ-STANAQKPSKRLPPIGSFSLPTAAPEQNRPS------------------------LLWES 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 276 KRLDKENRARRGRDLDDREagqdnlhhfpekrkssrraealEAYSGSASHSEKDNLKSMYKQAFvfcEKVKDRLCSQDDY 355
Cdd:COG5602 378 PRSISNISRYRADLLTSFS----------------------RNFVPIRIHMPISHLSNESEDFF---ERIKQYLKDKNLY 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 356 QTFLKCLNIFSNGIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESItdgfqrlagvmskklfssEEQLSRPMKveeke 435
Cdd:COG5602 433 HEFLKLLNLYSQKIIDKNDLVERLFAFLGSNEELIRWFKAFINYSEPE------------------KEPLRETRK----- 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 436 sehkpeleavketeqckkeymgksiqelDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSV-TSGSEDYSF 514
Cdd:COG5602 490 ----------------------------DLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHpTWASEDSGF 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 515 KHMRRNQYEESLFRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIER----LYG-DH 589
Cdd:COG5602 542 IAHRKNQYEEALFKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKvikkVYDkEH 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 590 GLDVIDILNKNPATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKEL 669
Cdd:COG5602 622 APEILEALLKKPHVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDR 701
|
...
gi 257675367 670 KEK 672
Cdd:COG5602 702 SQA 704
|
|
| Sin3a_C |
pfam16879 |
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ... |
1100-1343 |
4.81e-52 |
|
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.
Pssm-ID: 465294 Cd Length: 281 Bit Score: 184.73 E-value: 4.81e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1100 FYGNDDFYVLFRLHQILYERILYAKRNCS--GGELKSKN-------------------LKDTNAGDPYARFMRVLYGLLD 1158
Cdd:pfam16879 1 FFANTTIYVFFRLFQILYERLLKIKQAEEevAEEIKRRKankpakdlgliskeledfgLDLSDPEDYYPQLLELCERLID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1159 GSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYY-ENVRVLV-H 1236
Cdd:pfam16879 81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYrKQAEKLLgK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1237 EENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQ-------TELLSVSSGKKeeghdIVLQRNLTGL--- 1306
Cdd:pfam16879 161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSsyvlshpTEGVPRSKLRK-----PFLKRNLKAEree 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 257675367 1307 ---------YDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYF 1343
Cdd:pfam16879 236 eedeeeepkADAEEPEGPLEFESGLEIRICLNSYKLFYVPGTEDYF 281
|
|
| HDAC_interact |
smart00761 |
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ... |
467-563 |
6.65e-45 |
|
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.
Pssm-ID: 214808 [Multi-domain] Cd Length: 102 Bit Score: 157.47 E-value: 6.65e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 467 DCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDYSFKHMRRNQYEESLFRCEDDRFELDMLLESVSS 545
Cdd:smart00761 1 NCERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWaSEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSS 80
|
90
....*....|....*...
gi 257675367 546 AARSAESLLNIITEKKIS 563
Cdd:smart00761 81 TIKLLEEILNKIEDMSDE 98
|
|
| Sin3_corepress |
pfam08295 |
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms ... |
469-562 |
1.85e-39 |
|
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.
Pssm-ID: 462418 Cd Length: 97 Bit Score: 141.60 E-value: 1.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 469 ECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDY-SFKHMRRNQYEESLFRCEDDRFELDMLLESVSSA 546
Cdd:pfam08295 1 KRCGPSYRLLPKSEPQLPCSGRDELCWEVLNDEWVSHPTWaSEDSgSFVAHRKNQYEEALFRCEDERYEYDMHIESNLRT 80
|
90
....*....|....*.
gi 257675367 547 ARSAESLLNIITEKKI 562
Cdd:pfam08295 81 IKLLEPIAEKINNMSP 96
|
|
| Sin3 |
COG5602 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
1092-1341 |
5.90e-13 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 73.80 E-value: 5.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1092 ERTKDLQVFYGNDDFYVLFRLHQILYERILYAKRncsggeLKSKNLKDTNAGDPYARFMRVLYGLLDGSAENTKFEDECR 1171
Cdd:COG5602 852 EKQVIALTEFGNSLMYVFFRLRFDSYERLYEIKK------IKEAVTIGMMEPGHYENELWDSYRLIFGALTPCEFEKYLR 925
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1172 AIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYYEN-VR-VLVHEENIYRLECSSLP 1249
Cdd:COG5602 926 PFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSELFEMNSAASSKRKQDQTKYRLeVEsLLNPDEILFRFCWINKF 1005
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1250 SRLSIQLM---DNIIEKPEA-----------YAVSMDPTFASYMQTEL----LSVSSGKKEEGHDIVLQRNLTGLYdlck 1311
Cdd:COG5602 1006 KSFGIQIMkraDLTVDQSLDtqrvwkyyvqsYAIQHLTEGISYKNYKCpflcRNIEKERTVEQLVSRLQTKLLRSH---- 1081
|
250 260 270
....*....|....*....|....*....|
gi 257675367 1312 amegvEVVNGLECKMSCSSYKIAYVLDTED 1341
Cdd:COG5602 1082 -----ELVSGLQAFLCLDTFKLLYLPNTED 1106
|
|
| HN_RTEL1 |
cd13932 |
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); ... |
46-144 |
5.10e-04 |
|
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); Mouse Rtel is an essential protein required for the maintenance of both telomeric and genomic stability. RTEL1 appears to maintain genome stability by suppressing homologous recombination (HR). In vitro, purified human and insect RTEL1 have been shown to promote the disassembly of D loop recombination intermediates, in a reaction dependent upon ATP hydrolysis. Human RTEL1 is implicated in the etiology of Dyskeratosis congenital (DC, is an inherited bone marrow failure and cancer predisposition syndrome). Point mutations in its helicase domains, and truncations which result in loss of its C-terminus have been discovered in DC families. RTEL1 is also a candidate gene influencing glioma susceptibility. The C-terminal domain of RTEL1, represented here, appears similar to the N-terminal domain of the scaffolding protein harmonin.
Pssm-ID: 259826 [Multi-domain] Cd Length: 99 Bit Score: 40.72 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 46 SRRVSQKLTTNDALSYLREVKEMFqdQREKYDRFLEVMKDFKaQRTDTGGVIARVKELFKGHN--NLIYGFNTFLPkgye 123
Cdd:cd13932 8 SSSSGAKPAPESASAFLREVKQKL--SAAEYRQFSAALQAYK-TGDDFEQLLAVLAELFAEPErhPLLRGFRRFVR---- 80
|
90 100
....*....|....*....|.
gi 257675367 124 itlieeddalPKKTVEFEQAI 144
Cdd:cd13932 81 ----------PHHKKEFDERC 91
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
931-1072 |
2.16e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 42.68 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 931 LANGLRSDS-SKGTRNSDDPEGPSRNEKEEGELS-----PNGDFEDNFGVYKDHGVKSTSKPEN-SAEAEVEADAEVENE 1003
Cdd:TIGR00927 630 LSKGDVAEAeHTGERTGEEGERPTEAEGENGEESggeaeQEGETETKGENESEGEIPAERKGEQeGEGEIEAKEADHKGE 709
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257675367 1004 DDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1072
Cdd:TIGR00927 710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDE 778
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
886-1072 |
4.87e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 41.11 E-value: 4.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 886 GKEVLPGAHEIQAKPSDTLTDIHHDVDSIETVHSTQGGDVGNSIVLANG---LRSDSSKGTRNSDDPEGPSRNEKEEGEL 962
Cdd:PHA03169 34 GRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGekeERGQGGPSGSGSESVGSPTPSPSGSAEE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 963 SPNGDFEDNFGVYKDHGVKSTSKPEnsaeaeveadaevenEDDADDVDSENASEASGTESGGDVCSQ--DEDREEENGEH 1040
Cdd:PHA03169 114 LASGLSPENTSGSSPESPASHSPPP---------------SPPSHPGPHEPAPPESHNPSPNQQPSSflQPSHEDSPEEP 178
|
170 180 190
....*....|....*....|....*....|..
gi 257675367 1041 DEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1072
Cdd:PHA03169 179 EPPTSEPEPDSPGPPQSETPTSSPPPQSPPDE 210
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Sin3 |
COG5602 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
13-672 |
8.28e-88 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 311.47 E-value: 8.28e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 13 SQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVS-QKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRT 91
Cdd:COG5602 85 EDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPPRIPyRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAI 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 92 DTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEED----------------------------------------- 130
Cdd:COG5602 165 DTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQpngsrlhvttpqgplssppvqssyyvapcnhdqrtshptlp 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 131 ---------------DALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDL 195
Cdd:COG5602 245 sdsqpepsapshmpsDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDL 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 196 LEQFTRFLPASlpSHSAAQhSRSQAQQYSDRGSDPPLLHQMQVEKERRRERavalrgdysverydlnddktmvkiQREQR 275
Cdd:COG5602 325 LEEFKEFLPDS--SVSAEQ-STANAQKPSKRLPPIGSFSLPTAAPEQNRPS------------------------LLWES 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 276 KRLDKENRARRGRDLDDREagqdnlhhfpekrkssrraealEAYSGSASHSEKDNLKSMYKQAFvfcEKVKDRLCSQDDY 355
Cdd:COG5602 378 PRSISNISRYRADLLTSFS----------------------RNFVPIRIHMPISHLSNESEDFF---ERIKQYLKDKNLY 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 356 QTFLKCLNIFSNGIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESItdgfqrlagvmskklfssEEQLSRPMKveeke 435
Cdd:COG5602 433 HEFLKLLNLYSQKIIDKNDLVERLFAFLGSNEELIRWFKAFINYSEPE------------------KEPLRETRK----- 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 436 sehkpeleavketeqckkeymgksiqelDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSV-TSGSEDYSF 514
Cdd:COG5602 490 ----------------------------DLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHpTWASEDSGF 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 515 KHMRRNQYEESLFRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIER----LYG-DH 589
Cdd:COG5602 542 IAHRKNQYEEALFKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKvikkVYDkEH 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 590 GLDVIDILNKNPATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKEL 669
Cdd:COG5602 622 APEILEALLKKPHVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDR 701
|
...
gi 257675367 670 KEK 672
Cdd:COG5602 702 SQA 704
|
|
| Sin3a_C |
pfam16879 |
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ... |
1100-1343 |
4.81e-52 |
|
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.
Pssm-ID: 465294 Cd Length: 281 Bit Score: 184.73 E-value: 4.81e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1100 FYGNDDFYVLFRLHQILYERILYAKRNCS--GGELKSKN-------------------LKDTNAGDPYARFMRVLYGLLD 1158
Cdd:pfam16879 1 FFANTTIYVFFRLFQILYERLLKIKQAEEevAEEIKRRKankpakdlgliskeledfgLDLSDPEDYYPQLLELCERLID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1159 GSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYY-ENVRVLV-H 1236
Cdd:pfam16879 81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYrKQAEKLLgK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1237 EENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQ-------TELLSVSSGKKeeghdIVLQRNLTGL--- 1306
Cdd:pfam16879 161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSsyvlshpTEGVPRSKLRK-----PFLKRNLKAEree 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 257675367 1307 ---------YDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYF 1343
Cdd:pfam16879 236 eedeeeepkADAEEPEGPLEFESGLEIRICLNSYKLFYVPGTEDYF 281
|
|
| HDAC_interact |
smart00761 |
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ... |
467-563 |
6.65e-45 |
|
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.
Pssm-ID: 214808 [Multi-domain] Cd Length: 102 Bit Score: 157.47 E-value: 6.65e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 467 DCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDYSFKHMRRNQYEESLFRCEDDRFELDMLLESVSS 545
Cdd:smart00761 1 NCERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWaSEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSS 80
|
90
....*....|....*...
gi 257675367 546 AARSAESLLNIITEKKIS 563
Cdd:smart00761 81 TIKLLEEILNKIEDMSDE 98
|
|
| Sin3_corepress |
pfam08295 |
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms ... |
469-562 |
1.85e-39 |
|
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.
Pssm-ID: 462418 Cd Length: 97 Bit Score: 141.60 E-value: 1.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 469 ECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDY-SFKHMRRNQYEESLFRCEDDRFELDMLLESVSSA 546
Cdd:pfam08295 1 KRCGPSYRLLPKSEPQLPCSGRDELCWEVLNDEWVSHPTWaSEDSgSFVAHRKNQYEEALFRCEDERYEYDMHIESNLRT 80
|
90
....*....|....*.
gi 257675367 547 ARSAESLLNIITEKKI 562
Cdd:pfam08295 81 IKLLEPIAEKINNMSP 96
|
|
| PAH |
pfam02671 |
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ... |
159-203 |
1.79e-15 |
|
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.
Pssm-ID: 460645 [Multi-domain] Cd Length: 45 Bit Score: 71.30 E-value: 1.79e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 257675367 159 HVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDLLEQFTRFL 203
Cdd:pfam02671 1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
|
|
| PAH |
pfam02671 |
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ... |
74-118 |
3.15e-15 |
|
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.
Pssm-ID: 460645 [Multi-domain] Cd Length: 45 Bit Score: 70.53 E-value: 3.15e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 257675367 74 EKYDRFLEVMKDFKAQRTDTGGVIARVKELFKGHNNLIYGFNTFL 118
Cdd:pfam02671 1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
|
|
| PAH |
pfam02671 |
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ... |
353-397 |
2.24e-13 |
|
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.
Pssm-ID: 460645 [Multi-domain] Cd Length: 45 Bit Score: 65.52 E-value: 2.24e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 257675367 353 DDYQTFLKCLNIFSNGIIQRKDLQNLVSDLLGKFPDLMDEFNQFF 397
Cdd:pfam02671 1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
|
|
| Sin3 |
COG5602 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
1092-1341 |
5.90e-13 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 73.80 E-value: 5.90e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1092 ERTKDLQVFYGNDDFYVLFRLHQILYERILYAKRncsggeLKSKNLKDTNAGDPYARFMRVLYGLLDGSAENTKFEDECR 1171
Cdd:COG5602 852 EKQVIALTEFGNSLMYVFFRLRFDSYERLYEIKK------IKEAVTIGMMEPGHYENELWDSYRLIFGALTPCEFEKYLR 925
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1172 AIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYYEN-VR-VLVHEENIYRLECSSLP 1249
Cdd:COG5602 926 PFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSELFEMNSAASSKRKQDQTKYRLeVEsLLNPDEILFRFCWINKF 1005
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 1250 SRLSIQLM---DNIIEKPEA-----------YAVSMDPTFASYMQTEL----LSVSSGKKEEGHDIVLQRNLTGLYdlck 1311
Cdd:COG5602 1006 KSFGIQIMkraDLTVDQSLDtqrvwkyyvqsYAIQHLTEGISYKNYKCpflcRNIEKERTVEQLVSRLQTKLLRSH---- 1081
|
250 260 270
....*....|....*....|....*....|
gi 257675367 1312 amegvEVVNGLECKMSCSSYKIAYVLDTED 1341
Cdd:COG5602 1082 -----ELVSGLQAFLCLDTFKLLYLPNTED 1106
|
|
| HN_RTEL1 |
cd13932 |
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); ... |
46-144 |
5.10e-04 |
|
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); Mouse Rtel is an essential protein required for the maintenance of both telomeric and genomic stability. RTEL1 appears to maintain genome stability by suppressing homologous recombination (HR). In vitro, purified human and insect RTEL1 have been shown to promote the disassembly of D loop recombination intermediates, in a reaction dependent upon ATP hydrolysis. Human RTEL1 is implicated in the etiology of Dyskeratosis congenital (DC, is an inherited bone marrow failure and cancer predisposition syndrome). Point mutations in its helicase domains, and truncations which result in loss of its C-terminus have been discovered in DC families. RTEL1 is also a candidate gene influencing glioma susceptibility. The C-terminal domain of RTEL1, represented here, appears similar to the N-terminal domain of the scaffolding protein harmonin.
Pssm-ID: 259826 [Multi-domain] Cd Length: 99 Bit Score: 40.72 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 46 SRRVSQKLTTNDALSYLREVKEMFqdQREKYDRFLEVMKDFKaQRTDTGGVIARVKELFKGHN--NLIYGFNTFLPkgye 123
Cdd:cd13932 8 SSSSGAKPAPESASAFLREVKQKL--SAAEYRQFSAALQAYK-TGDDFEQLLAVLAELFAEPErhPLLRGFRRFVR---- 80
|
90 100
....*....|....*....|.
gi 257675367 124 itlieeddalPKKTVEFEQAI 144
Cdd:cd13932 81 ----------PHHKKEFDERC 91
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
931-1072 |
2.16e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 42.68 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 931 LANGLRSDS-SKGTRNSDDPEGPSRNEKEEGELS-----PNGDFEDNFGVYKDHGVKSTSKPEN-SAEAEVEADAEVENE 1003
Cdd:TIGR00927 630 LSKGDVAEAeHTGERTGEEGERPTEAEGENGEESggeaeQEGETETKGENESEGEIPAERKGEQeGEGEIEAKEADHKGE 709
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257675367 1004 DDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1072
Cdd:TIGR00927 710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDE 778
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
886-1072 |
4.87e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 41.11 E-value: 4.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 886 GKEVLPGAHEIQAKPSDTLTDIHHDVDSIETVHSTQGGDVGNSIVLANG---LRSDSSKGTRNSDDPEGPSRNEKEEGEL 962
Cdd:PHA03169 34 GRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGekeERGQGGPSGSGSESVGSPTPSPSGSAEE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 963 SPNGDFEDNFGVYKDHGVKSTSKPEnsaeaeveadaevenEDDADDVDSENASEASGTESGGDVCSQ--DEDREEENGEH 1040
Cdd:PHA03169 114 LASGLSPENTSGSSPESPASHSPPP---------------SPPSHPGPHEPAPPESHNPSPNQQPSSflQPSHEDSPEEP 178
|
170 180 190
....*....|....*....|....*....|..
gi 257675367 1041 DEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1072
Cdd:PHA03169 179 EPPTSEPEPDSPGPPQSETPTSSPPPQSPPDE 210
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
915-1055 |
5.69e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 40.72 E-value: 5.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257675367 915 ETVHSTQGGDVGNSIVLANGLR-SDSSKGTRNSDDPEGPSRNEKEEGELSPNGDFEDNFGVYKDHGvKSTSKPENSAEAE 993
Cdd:PHA03169 98 ESVGSPTPSPSGSAEELASGLSpENTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQP-SSFLQPSHEDSPE 176
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 257675367 994 VEADAEVENEDDADDV-DSENASEASGTESGGDvcSQDEDREEENGEHDEIDGK--AESEGEAEG 1055
Cdd:PHA03169 177 EPEPPTSEPEPDSPGPpQSETPTSSPPPQSPPD--EPGEPQSPTPQQAPSPNTQqaVEHEDEPTE 239
|
|
| |
