|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
39-471 |
6.69e-161 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 462.43 E-value: 6.69e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 39 EAKAQMIYSLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSGFAFMVGLSGSLETLCGQGFGAKRYRMLG 118
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 119 VHLQSSCIVSLVFSILITIFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIFSFV 198
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 199 PLVINIATAYVLVYVAGLGFIGAPIATSISLWIAFLSLGTYVMCSEKFKETWTGFSLESFRYIVINLTLSLPSAAMVCLE 278
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 279 YWAFEILVFLAGVMPnPEINTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLALGVV 358
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 359 IVLLVGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPIAAFCGFKL 438
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|...
gi 257661660 439 KFYAKGLWIGLICGIFCQSSSLLLMTIFRKWTK 471
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDK 432
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
39-468 |
4.16e-54 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 187.32 E-value: 4.16e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 39 EAKAQMIYSLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANS-WATVsgFAFMVGLSGSLETLCGQGFGAKRYRML 117
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSlWFPV--FTFGMGLLLAVTPLVAQAHGAGDRRRI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 118 GVHLQSSCIVSLVFSILITIFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIFSF 197
Cdd:cd13131 79 RRAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 198 VPLVINIATAYVLVY----VAGLGFIGAPIATSISLWIAFLSLGTYVMCSEKFKE-----TWTGFSLESFRYIvinLTLS 268
Cdd:cd13131 159 LALVLNIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRyrlfaRFWRPDWARLKEL---LRLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 269 LPSAAMVCLEYWAFEILVFLAGvmpnpEINTSLVA---ICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSV 345
Cdd:cd13131 236 LPIGLTIFFEVSLFAAVALLMG-----RLGTTVLAahqIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 346 SVKLSLVLALGVVIVLLVGHDGWVGLFS-DSYVIkeEFASLRFFLAASITL-DSIQGVLSGVARGCGWQRLVTVINLATF 423
Cdd:cd13131 311 GLGLGVGFAALTALLLLLFPEQIAGLYTnDPAVI--ALAASLLVFAALFQLfDGIQVVAAGALRGYKDTRVPFLLALISY 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 257661660 424 YLIGMPIAAFCGFKLKFYAKGLWIGLICGIFCqsSSLLLMTIFRK 468
Cdd:cd13131 389 WGIGLPLGYLLAFTTGLGAFGVWIGLIIGLAL--AAILLLWRFRR 431
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
49-374 |
9.45e-51 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 175.90 E-value: 9.45e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 49 PMILTNVFYYCIPITSVMFASHLGQLELAGATLANSwATVSGFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCIVS 128
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSS-VFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 129 LVFSILITIFWFFTES-IFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIFSFVPLVINIATA 207
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDpLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 208 YVLVYV--AGLGFIGAPIATSISLWIAFLSLGTYVMCSEKFKETWTGFSLESFRYIVINLTLSLPSAAMVCLEYWAFEIL 285
Cdd:TIGR00797 160 YILIFGkfGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 286 VFLAGvmPNPEINTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLALGVVIVLLVGH 365
Cdd:TIGR00797 240 ALLVA--RLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317
|
....*....
gi 257661660 366 DGWVGLFSD 374
Cdd:TIGR00797 318 EFIARLFTN 326
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
46-463 |
2.18e-49 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 174.56 E-value: 2.18e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 46 YSLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSgFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSC 125
Cdd:COG0534 13 LALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVLGQAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 126 IVSLVFSILITIF-WFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIFSFVPLVINI 204
Cdd:COG0534 92 LLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 205 ATAYVLVYVAGLGFIGAPIATSISLWIAFLSLGTYVMcsekFKETWTGFSLESFR----YIVINLTLSLPSAAMVCLEYW 280
Cdd:COG0534 172 VLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLF----RKRSLLRLRLRDLRpdrkILKRILRIGLPAGLQQLAESL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 281 AFEILVFLAGVMPNPEIntSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLALGVVIV 360
Cdd:COG0534 248 GFLVLNALVARLGTAAV--AAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 361 LLVGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPIAAFCGFkLKF 440
Cdd:COG0534 326 LFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LGL 404
|
410 420
....*....|....*....|...
gi 257661660 441 YAKGLWIGLICGIFCQSSSLLLM 463
Cdd:COG0534 405 GLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
47-470 |
1.68e-39 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 147.66 E-value: 1.68e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVsGFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCI 126
Cdd:cd13137 7 AWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWL-LLVLNMALGTGTVALVSQSYGAGDYERARRALGQSLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 127 VSLVFSILITIF-WFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQ---NILRfCQTQSIIaPLVIFSFVpLVI 202
Cdd:cd13137 86 LALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLvgnAALR-GAGDTKT-PMYIMIIV-NVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 203 NIATAYVLVY----VAGLGFIGAPIATSISLWIAFLsLGTYVMCSEK----FKETWTGFSLESFRYIvinLTLSLPSAAM 274
Cdd:cd13137 163 NIVLDYVLIFglwgFPGLGVAGAALATVISRVVGAL-LLLFLLLRGRlpikISFKGFRLDRKIIKKL---LRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 275 VCLeyWAFEILVFLAGVMPNPEINTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLA 354
Cdd:cd13137 239 QLL--RSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFM 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 355 LGVVIVLLVGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPIAAFC 434
Cdd:cd13137 317 GLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLL 396
|
410 420 430
....*....|....*....|....*....|....*.
gi 257661660 435 GFKLKFYAKGLWIGLICGIFCQSSSLLLMTIFRKWT 470
Cdd:cd13137 397 GFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-469 |
3.58e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 144.21 E-value: 3.58e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVsGFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCI 126
Cdd:cd13133 11 ALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFA-ILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQGLY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 127 VSLVFS-ILITIFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYgFLQNILR-FCQTQSIIAPLVIFSFVPLVINI 204
Cdd:cd13133 90 FSLLLApLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFS-LLGAALRaFFSGIGRTRVVMVANLVMVVVNI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 205 ATAYVLVYVAG----LGFIGAPIATSISLWIAFLSLGTYVMCSEKFKET----WTGFSLESFRYIvinLTLSLPSAAMVC 276
Cdd:cd13133 169 VLDYALIFGKLgfpaMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFglrrAWRFDRELLRRI---LRLGLPSGLQFF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 277 LEYWAFEILVFLAGVMPnpEINTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLALG 356
Cdd:cd13133 246 LDVGAFTVFFLLIGRLG--TTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 357 VVIVLLVGHDGWVGLFS---DSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPIAAF 433
Cdd:cd13133 324 LGILFLLFPELLLSIFTpgaDFALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYL 403
|
410 420 430
....*....|....*....|....*....|....*.
gi 257661660 434 cGFKLKFYAKGLWIGLICGIFCQSSSLLLMTIFRKW 469
Cdd:cd13133 404 -LVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
38-468 |
1.73e-35 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 137.25 E-value: 1.73e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 38 EEAKAQMIYSLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANS-WATVsgFAFMVGLSGSLETLCGQGFGAKRYRM 116
Cdd:PRK01766 9 SEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSiWLPV--ILFGHGLLLALTPIVAQLNGAGRRER 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 117 LGVHLQSSCIVSLVFSILI-TIFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIF 195
Cdd:PRK01766 87 IAHQVRQGLWLALFLSVLImLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 196 SFVPLVINIATAYVLVY----VAGLGFIGAPIATSISLWIAFLSLGTYVMCSEKFKE--TWTGFSLESFRYIVINLTLSL 269
Cdd:PRK01766 167 GFLGLLINIPLNYIFIYgkfgFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDfrLFKGLYKPDWAVIKRLLKLGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 270 PSAAMVCLEYWAFEILVFLAGvmpnpEINTSLVA---ICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVS 346
Cdd:PRK01766 247 PIGLAIFFEVSLFAVVTLLVS-----PLGTVTVAahqIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 347 VKLSLVLALGVVIVLLVGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLI 426
Cdd:PRK01766 322 LAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVL 401
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 257661660 427 GMPIAAFCGFKLKFYAKGLWIGLICGIFcqSSSLLLMTIFRK 468
Cdd:PRK01766 402 GLPLGYILALTDPMGPFGFWIGLIIGLT--AAAILLLLRLRK 441
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
47-462 |
3.07e-29 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 118.97 E-value: 3.07e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSwATVSGFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCI 126
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFP-LIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 127 VSLVFSILITIF-WFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIFSFVPLVINIA 205
Cdd:cd12082 80 LAILLGLLLAALlLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 206 TAYVLVY---VAGLGFIGAPIATSISLWIAFLSLGTYVMCSEKFKETWTGFSLESFRYIVINLTLSLPSAAMVCLEYWAF 282
Cdd:cd12082 160 LDPLLIFglgPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 283 EILVFLAGVMPNPEInTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLALGVVIVLL 362
Cdd:cd12082 240 LIIVAIVAAFGGAAA-LAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 363 VGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPiAAFCGFKLKFYA 442
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLP-LAYVLAYLGLGL 397
|
410 420
....*....|....*....|
gi 257661660 443 KGLWIGLICGIFCQSSSLLL 462
Cdd:cd12082 398 YGIWLALVISLILAALVLLL 417
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
41-471 |
3.79e-26 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 110.24 E-value: 3.79e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 41 KAQMIYSLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSGFAFMVGLSGSLETLCGQGFGAKRYRMLGVH 120
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 121 LQSSCIVSLVFSILITIF-WFFTESIFGLLRQDPSISKQAALYMKYQA---PGLLAYGFLQNILRfcqtqSI---IAPLv 193
Cdd:cd13138 83 VGTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYLRICFlgiPFIFGYNAYSAILR-----GLgdsKTPL- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 194 IFSFVPLVINIATAYVLVYVAGLGFIGAPIATSISLWIAFLSLGTYVmcseKFKETWTGFSLESFRY----IVINLTLSL 269
Cdd:cd13138 157 YFVIIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYL----RKKKLPFKLSLKDFRFdkeiLKEILKIGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 270 PSAAMvcleywafEILVFLAGVMPNPEIN------TSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKAT 343
Cdd:cd13138 233 PSALQ--------QSLVSISFLIINSIVNsygvvaSAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 344 SVSVKLSLVLALGVVIVLLVGHDGWVGLF-SDSYVIKEEFASLRFFLAASITLdSIQGVLSGVARGCGWQRLVTVINLAT 422
Cdd:cd13138 305 RTGIIISLIIGLIIILLVFFFAPQLLGLFtSDPEVIEIGAEYLRIYSIDYILF-GILFVFNGLFRGLGKTKFPMIISILR 383
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 257661660 423 FYLIGMPIAAFCGFKLKFYAKGLWIGLICGIFCqsSSLLLMTIFRKWTK 471
Cdd:cd13138 384 LWLVRIPLAYLLSRLTGLGLFGIWLAMPISNIL--SAIICIIYYRKGRW 430
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
49-209 |
1.08e-24 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 99.95 E-value: 1.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 49 PMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSgFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCIVS 128
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 129 LVFSILITIF-WFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIFSFVPLVINIATA 207
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 257661660 208 YV 209
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-451 |
5.14e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 101.04 E-value: 5.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANswaTVSGFAFMV--GLSGSLETLCGQGFGAKRYRMLGVHLQSS 124
Cdd:cd13134 9 AWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVAN---QILFLLILIfsFISTGTSILIAQYLGAKDKKKARQIAGVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 125 CIVSLVFSILIT-IFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGF---LQNILRfcQTQSIIAPLVIfSFVPL 200
Cdd:cd13134 86 LLFNLLLGLVFSlLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALsltLSAILR--SHGRTKIPMYV-SLIMN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 201 VINIATAYVLVYVAG----LGFIGAPIATSISLWIAFLSLGTYVMCSEKFKETWTGFSLESFRYIVINLTLSLPSAamvc 276
Cdd:cd13134 163 ILNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSA---- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 277 LEY--WAFEILVFLA--GVMPNPEINTslVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLV 352
Cdd:cd13134 239 GEElsYNLSQTVITAfiARLGTAALAA--RTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 353 LALGVVIVLLVGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPIAA 432
Cdd:cd13134 317 VSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAY 396
|
410
....*....|....*....
gi 257661660 433 FCGFKLKFYAKGLWIGLIC 451
Cdd:cd13134 397 LLGIVLGLGLLGVWIAFAA 415
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-450 |
2.40e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 93.03 E-value: 2.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLanSWATV-SGFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSC 125
Cdd:cd13142 17 AWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSI--SWPLIfLFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 126 IVSLVFSILITIF-WFFTESIF-GLLRQDPSISKQAALYMKYQAPGL-LAYGFL--QNILRfcqtqSI---IAPLVIfSF 197
Cdd:cd13142 95 SFVIILSLILAVLgYILSRPLLlLLIGAPEEVYPLALAYLRIIFLGLpFMFIFFvfNSLLR-----GIgdtKTPMKI-MF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 198 VPLVINIATAYVLVY----VAGLGFIGAPIATSISLWIAfLSLGTYVMCSEK--FKETWTGFSLEsFRYIVINLTLSLPS 271
Cdd:cd13142 169 GSVLLNVILDPLLIFgigpFPGLGVAGAALATVISRGIA-AVIGLYLLFKGRvgLKISLRDLKPD-WEWLKKIFRIGLPS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 272 AAMVCLEYWAFEILVFLAGVMPnpeinTSLVA---ICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVK 348
Cdd:cd13142 247 SIEQSARALGFTVMTALVAGFG-----TVVVAaygIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAAL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 349 L-SLVLALGVVIVLLVGhDGWVGLF-SDSYVIKEEFASLRFFlAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLI 426
Cdd:cd13142 322 LiFLILVIGGVLAFLFA-EPIVRVFiNDPEVIKEGADFLRIV-APSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVI 399
|
410 420
....*....|....*....|....
gi 257661660 427 GMPIAAFCGFKLKFYAKGLWIGLI 450
Cdd:cd13142 400 RIPLAYLLAYVLGLGVTGIWIAMA 423
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
46-431 |
2.02e-17 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 84.10 E-value: 2.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 46 YSLPMILTNVFYYCIPITSVMFASHL-GQLELAGATLANSWAT-VSGFAFMVGLSGSleTLCGQGFGAKRYRMLGVHLQS 123
Cdd:cd13143 9 FALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKANRIFST 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 124 SCIVSLVFSILITI-FWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGF---LQNILRfCQTQSIIAPLVIFSFVp 199
Cdd:cd13143 87 ALLLSLILGLLLTIlGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILssvLNNLLR-AEGKPKLAMLGMLIGA- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 200 lVINIATAYVLVYVAGLGFIGAPIATSISLWIAFLSLGTYVMCSEKFKETWTGFSLESFRYIVINLTLSLPSAAMvcleY 279
Cdd:cd13143 165 -VLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLM----Q 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 280 WAFEILVFLAGVMPNPEINTSLVA---ICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLALG 356
Cdd:cd13143 240 LSSSVVTIVLNLTLLGYGGDIGVAafgIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLV 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 257661660 357 VVIVLLVGHDGWVGLFS-DSYVIKEEFASLRFFLAASItLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPIA 431
Cdd:cd13143 320 LFLILLLFPEQIVSLFTdDPELIALAARILRIFLLAFP-LAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLL 394
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-387 |
2.16e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 84.27 E-value: 2.16e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANS--WATVSgfaFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSS 124
Cdd:cd13135 7 AIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTpfNTITG---FLGSISIGFTILGSQSVGAKDIKRINDYAISS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 125 CIVSLVFSILITIFWFFTES-IFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIFSFVPLVIN 203
Cdd:cd13135 84 IVYNSIIGVILFLLWLFGARiIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 204 IATAYVLVY----VAGLGFIGAPIATSISLWIAFLSLGTYVMCSEKFKETWTGFSLESFRYI--VINLTLSLPSAamvcL 277
Cdd:cd13135 164 VILDYVLIFgnfgFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRpyKFTIKLGLPLG----G 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 278 EYWAFEILVFLAGVMPN--PEINTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLAL 355
Cdd:cd13135 240 EEFLWNIGNLAVIRILNriGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYI 319
|
330 340 350
....*....|....*....|....*....|...
gi 257661660 356 GVVIVLLVGHDGWVGLFS-DSYVIKEEFASLRF 387
Cdd:cd13135 320 AAAIVFLAFPYKILSLFTnDPELINYSIPYLIF 352
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
270-431 |
7.69e-17 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 77.61 E-value: 7.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 270 PSAAMVCLEYWAFEILVFLAGVMPnpEINTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKL 349
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 350 SLVLALGVVIVLLVGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATfYLIGMP 429
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157
|
..
gi 257661660 430 IA 431
Cdd:pfam01554 158 LN 159
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-407 |
7.18e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 79.49 E-value: 7.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLAnswatvsgfAFMVGLSGSL--------ETLCGQGFGAKRYRMLG 118
Cdd:cd13140 11 ALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTA---------GFFVWLAYALallskigaQVKVSQSIGAKDEKEAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 119 VHLQSSCIVSLVFSILITIF-WFFTESIFGLLR-QDPSISKQAALYMKYQAPGLLAYgFLQNILrfcqTQSIIA------ 190
Cdd:cd13140 82 KYARNALQLNLLLGILYGLLlLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFS-FLNPVF----TGIFNAlgdskt 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 191 PLVIfSFVPLVINIATAYVLVYVAG----LGFIGAPIATSISLWIAFLSLGTYVMCSEKFKETWTGFSLESFRYIVINLT 266
Cdd:cd13140 157 PFII-NAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 267 LSLPSAAMVCLeyWAFeILVFLAGVMpnpeinTSL--VAICVNT-----EAISYMLTYGLSAAASTRVSNELGAGNVKGA 339
Cdd:cd13140 236 LGLPVALQSIL--FAL-ISMILARII------ASFgpVAIAAQKvgsqiESISWMTAEGFSTALAAFVGQNYGAGKYDRI 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 257661660 340 KKATSVSVKLSLVLALGVVIVLLVGHDGWVGLF-SDSYVIKEEFASLR------FFLAASITldsIQGVLSGVAR 407
Cdd:cd13140 307 RKGYKTALKIASAIGLFATLLLFFFGEPLFSLFiPDPETIAIGVDYLRilgfsqLFMCLEIT---TTGAFNGLGR 378
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
47-462 |
3.30e-13 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 71.05 E-value: 3.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVfyyCIPITS---VMFASHLGQL-ELAGATLAnswATVSGFAFMVG--LSGSLETLCGQGFGAKRYRMLGVH 120
Cdd:cd13136 9 ALPAILSNI---TVPLLGlvdTAVVGHLGSAaYLGAVALG---TTIFNTLFWLFgfLRMGTTGLVAQALGAGDREEAIAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 121 LQSSCIVSLVFSILITIFWF-FTESIFGLLRQDPSISKQAALYMKYQAPG----LLAYGFLQNILRFCQTQsiiAPLVIf 195
Cdd:cd13136 83 LVRALLLALAIGLLLILLQSpLLALALLLLGASAAVAALARQYLRIRILGapavLLNYVATGWFRGLQDTR---TPLIL- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 196 SFVPLVINIATAYVLVYVAGLGFIGAPIATSISLWIAFLSLGtyVMCSEKFKETWTGFSLESF------RYIVINLTLSL 269
Cdd:cd13136 159 QIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGL--WLLRRRVRLLGKSLSRRLPskaalkRLFKLNRDIFI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 270 PSAAMVCleywAFEILVFLAGVMPNPEINTslVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKL 349
Cdd:cd13136 237 RTLALLA----AFLFFTALAARLGDVILAA--NQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQW 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 350 SLVLALGVVIVLLVGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRlvtvinlatfYLIGMP 429
Cdd:cd13136 311 GLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTR----------YLRNSM 380
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 257661660 430 IAAFCGFKLKFYA-------KGLWIGLICGIFCQSSSLLL 462
Cdd:cd13136 381 LVSLAVFLPLLFLlvplwgnHGLWLALILFMLLRGLTLAL 420
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
39-462 |
5.74e-13 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 70.54 E-value: 5.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 39 EAKAQMIYSLPMILTNVFYYCIPITSVMFASHLGQLELAGATL-ANSWATVSgfAFMVGLSGSLETLCGQGFGAKRYRML 117
Cdd:PRK00187 8 ELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLgAASYSFVS--IFCVGVIAAVGTLVAIRHGAGDIEGA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 118 GVHLQSSCIVSLVFSILITIFWFFTESIFGLLRQDPSISKQAALYMK---YQAPGLLAYGFLQNilrFCQTQSIIAPLVI 194
Cdd:PRK00187 86 TRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHllpFALPGYLSFMALRG---FTSALGRAGPVMV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 195 FSFVPLVINIATAYVLVY----VAGLGFIGAPIATSISLWIAFLSLGTYVMCSEKFKE--TWTGFSLESFRYIVINLTLS 268
Cdd:PRK00187 163 ISLAGAVANLLLNYALIEgwfgLPKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAypLRKGLSRPSRAALRELWRLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 269 LPSAAMVCLEYWAFEILVFLAGVMPNPEINTSLVAIcvNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVK 348
Cdd:PRK00187 243 LPIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIAL--QIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 349 LSLVLALGVVIVLLVGHDGWVGLFSD-----SYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATF 423
Cdd:PRK00187 321 FGAVVMLLFAGLFWLLPEAIIGLFLDrndpaFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACY 400
|
410 420 430
....*....|....*....|....*....|....*....
gi 257661660 424 YLIGMPIAAFCGFKLKFYAKGLWIGLICGIFCQSSSLLL 462
Cdd:PRK00187 401 WLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVALTL 439
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
21-239 |
8.20e-13 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 69.79 E-value: 8.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 21 RGRRSRSSTLVQKVIDVEEAKAQMIYSLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSgFAFMVGLSGS 100
Cdd:COG0534 209 RKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 101 LETLCGQGFGAKRYRMLGVHLQSSCIVSLVFSILIT-IFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGF---L 176
Cdd:COG0534 288 AQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLAlLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLqfvL 367
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257661660 177 QNILRfcQTQSIIAPLVIFSFVPLVINIATAYVLVYvAGLGFIGAPIATSISLWIAFLSLGTY 239
Cdd:COG0534 368 SGALR--GAGDTRFPMIISLLRLWLVRLPLAYLLAF-LGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
41-448 |
1.69e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 63.01 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 41 KAQMIYSLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSgFAFMVGLSGSLETLCGQGFGAKRYRMLGVH 120
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIV-YSIAIGLSMAATALVARRIGEKDPEGAGFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 121 LQSSCIVSLVFS-ILITIFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLA--YGFLQN-ILRFCQTQSIIAPLVIFS 196
Cdd:cd13139 93 AVQAILLGVALSlILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFimLLFLINgIFRGAGDAAIAMRSLWLA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 197 FVplvINIATAYVLVYvaGLGFI------GAPIATSISLWIAFLsLGTYVMCSEKFKETwTGFSLESFRYIVINLTLSLP 270
Cdd:cd13139 173 NG---LNIILDPLFIF--GLGPIpamgvtGAAIATTIGRSIGVL-YQLYHLFKGKGRIQ-IRRRHLKLDWAIIKKIIKIA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 271 SAAMVcleYWAFEILVFLAGVMPNPEINTSLVA---ICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSV 347
Cdd:cd13139 246 VGGIL---QFLIASSSWIFLVRIIAEFGSTALAgytIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 348 KLSLVLALGVVIVLLVGHDGWVGLFS-DSYVIKEEFASLRFFLAASITLdSIQGVLSGVARGCGWQRLVTVINLATFYLI 426
Cdd:cd13139 323 KYNMVFLGIVSLVFFLFAEPLVSFFTtDPEVIAIAVEALRIISLGYIFY-GYGMVLSQAFNGAGDTKTPTLINLVGFWLF 401
|
410 420
....*....|....*....|..
gi 257661660 427 GMPIAAFCGFKLKFYAKGLWIG 448
Cdd:cd13139 402 QIPLAYLLARHLNLGPKGVFIA 423
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
62-407 |
6.47e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 57.99 E-value: 6.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 62 ITSVMFASHLGQLELAGATLANSwATVSGFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCIVSLVFSILITIF-WF 140
Cdd:cd13145 30 VVDTFFAGKISTEALAALSLSFP-IFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIgLF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 141 FTESIFGLLRQDPSISKQAALYMK---YQAPGLLAYGFLQNILR-FCQTQSIIAPLVIFSFVPLVINIATAYVLVYVAGL 216
Cdd:cd13145 109 AAPPLFRLLGAEGDYLDLALEYMDvifAGSIFFLLNFGLNGILNaQGDTKSYRNFLIIGFFLNIILDPLFIFGGGGIPAM 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 217 GFIGAPIATSISLWIAFLSLGTYVMCSEKFKETWTGFSLESFRYIVINLTLSLPSA-AMVCLeywAFEILVFLAGVMPNP 295
Cdd:cd13145 189 GVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQGFPASlNMMTI---GLGIFVITYFVGQFG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 296 EINTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLALGVVIVLLVGHDGWVGLFS-D 374
Cdd:cd13145 266 DEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEPLMSLFTnD 345
|
330 340 350
....*....|....*....|....*....|....*.
gi 257661660 375 SYVIKEEFASLR---FFLAASITLDSIQGVLSGVAR 407
Cdd:cd13145 346 PAVIAIGAGYLRidaLIFYAYVVLFISVSVLQGLKR 381
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
21-240 |
3.11e-08 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 55.79 E-value: 3.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 21 RGRRSRSSTLVQKVIDVEEAKAQMIYSLPMILTNVFYYCIPITSVMFASHL-GQLELAGATLANSWATVSgFAFMVGLSG 99
Cdd:cd12082 199 KGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFgGAAALAAYTVAFRIASLA-FMPALGLAQ 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 100 SLETLCGQGFGAKRYRMLGVHLQSSCIVSLVFSILIT-IFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQN 178
Cdd:cd12082 278 AALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGlLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYV 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257661660 179 ILRFCQ-TQSIIAPLVIFSFVPLVINIATAYVLVYvAGLGFIGAPIATSISLWIAFLSLGTYV 240
Cdd:cd12082 358 LQAGFQaAGRTLKSLIVSLLSYWVVRLPLAYVLAY-LGLGLYGIWLALVISLILAALVLLLFF 419
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
91-234 |
3.81e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 55.28 E-value: 3.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 91 FAFMVGLSGSLETLCGQGFGAKRY-RMLGVHLQSSCIVSLVFSILITIFWFFTESIFGLLRQDPSISKQAALYMKYQAPG 169
Cdd:cd13142 286 FLPAFGLARATSTMVGQNLGAGQIdRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPS 365
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 257661660 170 LLAYGFLQNILR-FCQTQSIIAPLVIFSFVPLVINIATAYVLVYVAGLGFIGAPIATSISLWIAFL 234
Cdd:cd13142 366 FPFFGLFQVINGaFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAAL 431
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
91-360 |
2.12e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 53.17 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 91 FAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCIVSLVFSILITIF-WFFTESIFGLLRQDPSISKQAALYMKYQAPG 169
Cdd:cd13146 60 LALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLgYIFAEPLLQLLGAKGLLLEYALEYFYYSLPG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 170 LLAYGFLQNILRFCQTQSIIAPLVIFSFVPLVINIATAYVLVYVAGLGFIGAPIATSISLWIAFLSLgTYVMCSEKFKET 249
Cdd:cd13146 140 VPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYL-LYVFLIGKSNVT 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 250 wTGFSLESFRYIVINLTLSLPSAAMVCLEYWAFEILVFLAGVMPNPEINTSLVAICVNTEAISYMLTYGLSAAASTRVSN 329
Cdd:cd13146 219 -IHIKLSNISSSVIVEILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQ 297
|
250 260 270
....*....|....*....|....*....|....*
gi 257661660 330 ELGAGNVKGA----KKATSVSVKLSLVLALGVVIV 360
Cdd:cd13146 298 NWGRGNYDRMlqilMTAVILGIVVVLVLVLGYVLV 332
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
58-228 |
1.02e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 51.07 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 58 YCIPITSVMF----ASHLGQLELAGATLANSwatVSGFAFMV--GLSGSLETLCGQGFGAKRYRMLGVHLQSSCIVSLVF 131
Cdd:cd13139 252 FLIASSSWIFlvriIAEFGSTALAGYTIAIR---IIMFALLPawGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVF 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 132 SILITIFWF-FTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILR-FCQTQSIIAPLVIFSFVPLVINIATAYV 209
Cdd:cd13139 329 LGIVSLVFFlFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQaFNGAGDTKTPTLINLVGFWLFQIPLAYL 408
|
170
....*....|....*....
gi 257661660 210 LVYVAGLGFIGAPIATSIS 228
Cdd:cd13139 409 LARHLNLGPKGVFIAIPIA 427
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-235 |
7.54e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 48.27 E-value: 7.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 46 YSLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSgFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSC 125
Cdd:cd13134 233 IGLPSAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFV-FLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 126 IVSLVFSILIT-IFWFFTESIFGLLRQDPSISKQAALYmkyqapgLLAYGFLQ----------NILRfcQTQSIIAPLVI 194
Cdd:cd13134 312 KIGLLVSLAVAlLLALFREPILGLFTDDPEIIALGKTL-------LLISILLEpgrafnivliGSLR--AAGDARFPVLI 382
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 257661660 195 FSFVPLVINIATAYVLVYVAGLGFIGapiatsisLWIAFLS 235
Cdd:cd13134 383 GIISMWGISVPLAYLLGIVLGLGLLG--------VWIAFAA 415
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-446 |
9.73e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 48.00 E-value: 9.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSgFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCI 126
Cdd:cd13144 14 SIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANKAANNGLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 127 VSLVFSILITIFWFF-TESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQS-IIAPLvIFSFVPLVINI 204
Cdd:cd13144 93 LALLSYLLFLLLGLFgVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGnTITPM-IAQLIGAIINI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 205 ATAYVLVY----VAGLGFIGAPIATSISLWIAFLslgtYVMCSEKFKETWTGFSLESFR----YIVINLTLSLPSAAMVC 276
Cdd:cd13144 172 ILDPILIFglfgFPAMGIAGAAIATVIGQILAMF----LAFFFLLRKNKDVQPDLRLFRpslrIIKEIYAVGLPSIIMQA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 277 LeywaFEILVFLAGV--MPNPEINTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLA 354
Cdd:cd13144 248 I----SSVMVFGLNKilAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIM 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 355 LGVVIVLLVGHDGWVGLF-SDSYVIKEEFASLRfFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPIAAF 433
Cdd:cd13144 324 LAGGLLFQLFPDQLLGLFnASEEMLAIGVPALR-IISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAWL 402
|
410
....*....|...
gi 257661660 434 cgFKLKFYAKGLW 446
Cdd:cd13144 403 --LAKMFGLNGVW 413
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
95-241 |
1.92e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 43.74 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 95 VGLSGSLETLCGQGFGAKRYRMLGVHLQSSCIVSLVFSILITIF-WFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAY 173
Cdd:cd13145 287 IGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFlLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAY 366
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257661660 174 GFLQNILRFCQ-TQSIIAPLVIFSFVPLVINIATAYVLVYVAGLGFIGAPIATSISLWIAFLSLGTYVM 241
Cdd:cd13145 367 VVLFISVSVLQgLKRPIFALWIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTR 435
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-246 |
5.07e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 42.30 E-value: 5.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSgFAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCI 126
Cdd:cd13141 17 ALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFV-MALTQVLNVGTAALVSHAVGRKDQGEANAVFNQSLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 127 VSLVFSILITIF-WFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFLQNILRFCQTQSIIAPLVIFSFVPLVINIA 205
Cdd:cd13141 96 LAAVLGLVVLVLgYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVLLNII 175
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 257661660 206 TAYVLVYVAG----LGFIGAPIATSISLWIAFLSLGTYVMCSEKF 246
Cdd:cd13141 176 LAPILITGWGtgraLGVAGAGLASSISVAIAVVLLLYYFLRLEKY 220
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
94-220 |
6.03e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 42.00 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 94 MVGLSGSLETLCGQGFGAKRY-RMLGVHLQSSCIVSLVFSILITIFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLA 172
Cdd:cd13146 284 IFAISSALLTIAGQNWGRGNYdRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPF 363
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 257661660 173 YGFLQNILRFCQTQSIIAPLVIFSFVPL-VINIATAYVLVYVAGLGFIG 220
Cdd:cd13146 364 VAISILVTEFFQAIGKAWPSLLLTLIRHvFLSVPVVYLLAYVFGKGITG 412
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
91-471 |
1.10e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 41.37 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 91 FAFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCIVSLVFSILITI-FWFFTESIFGLLrqdpSISKQAALYMKYQAPG 169
Cdd:cd13147 58 IGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSILLGLIISIILTIvLLPFLEPILVLM----GAGEVLDLAVDYGRII 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 170 LL-AYGFLQN-----ILRF-CQTQSIIAPLVIFSfvplVINIATAYVLVYVAGLGFIGAPIATSISLWIAFLSLGtYVMC 242
Cdd:cd13147 134 FLgSIFLIFNnvaygILRGeGDTKRAMYAMVAGS----ILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLL-YWFF 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 243 SEkfKETWTGFSLESFRY---IVIN-LTLSLP-SAAMVCLEYWAFEILVFLAGVMPNPEINTSLVAICVNTEAISYMLty 317
Cdd:cd13147 209 VK--KDTYVSLSLKNFKFdkkIVKDiLKVGIPaSLEQLIMSVLMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLI-- 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 318 GLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVLALGVVIVLLVGHDGWVGLFSDSYVIKEEFASLRFFLA-ASITLD 396
Cdd:cd13147 285 GIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILIFIFAPQIAYLFTYSEESAHLAPEIVAFLRiMCLFLP 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 397 SIQ-GVLSG-VARGCGWQR---LVTVINLATFYLIgmpIAAFCGFKLKFYAKGLWIGLICGIFCqsSSLLLMTIFRKWTK 471
Cdd:cd13147 365 FVPfGMMSSsMFQGIGKGLtslIITILRELIFQVL---FAYLFAIVLGLGLFGVWWGIVLGNAI--GSIVGYLWARLYIK 439
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
47-234 |
1.49e-03 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 40.88 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVfyyCIPITSVMFASHLGQLE----LAGATLAnswATVSGFAFMVGLSGSLET--LCGQGFGAKRYRMLGVH 120
Cdd:PRK10367 15 ALPMIFSNI---TVPLLGLVDTAVIGHLDspvyLGGVAVG---ATATSFLFMLLLFLRMSTtgLTAQAFGAKNPQALARA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 121 LQSSCIVSLVFSILITIFWF-FTESIFGLLRQDPSISKQAALYMKYQ---APGLLAYGFLQNILrfCQTQSIIAPlVIFS 196
Cdd:PRK10367 89 LVQPLLLALGAGALIALLRTpLIDLALHIVGGSEAVLEQARRFLEIRwlsAPASLANLVLLGWL--LGVQYARAP-VILL 165
|
170 180 190
....*....|....*....|....*....|....*...
gi 257661660 197 FVPLVINIATAYVLVYVAGLGFIGAPIATSISLWIAFL 234
Cdd:PRK10367 166 VVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLL 203
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
47-431 |
2.84e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 39.98 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 47 SLPMILTNVFYYCIPITSVMFASHLGQLELAGATLANSWATVSGFaFMVGLSGSLETLCGQGFGAKRYRMLGVHLQSSCI 126
Cdd:cd13149 15 TLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNS-LTIGLGIGASAVISRAIGAGDRNKAKRLATDSLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 127 VSLVFSILI-TIFWFFTESIFGLLRQDPSISKQAALYMKYQAPGLLAYGFL---QNILRfcQTQSIIAPLVIFSFVPLVi 202
Cdd:cd13149 94 LSLLLSVIVsLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPmvgNAIIR--ATGDTKRPSLVMLGAALV- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 203 NIATAYVLVY----VAGLGFIGAPIATSISlWIAFLSLGTYVMcseKFKETWTGFSLESFRYIVIN----LTLSLPSA-A 273
Cdd:cd13149 171 NVILDPILIFgfgpIPGMGIAGAAIATVIS-RALGLGAALYFL---HYHHRLIDFSEPSLKALFRSwkdiLSIGIPAAlS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257661660 274 MVCLEYWAFEILVFLAGVMPNPeinTSLVAICVNTEAISYMLTYGLSAAASTRVSNELGAGNVKGAKKATSVSVKLSLVL 353
Cdd:cd13149 247 NILTPLSAAFITALVATYGPAA---VAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIY 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 257661660 354 ALGVVIVLLVGHDGWVGLFSDSYVIKEEFASLRFFLAASITLDSIQGVLSGVARGCGWQRLVTVINLATFYLIGMPIA 431
Cdd:cd13149 324 GAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLA 401
|
|
| |
