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Conserved domains on  [gi|225878001|emb|CAX65049|]
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Ig-like and fibronectin type-III domain-containing protein 2 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 189-280 6.11e-19

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


:

Pssm-ID: 460293  Cd Length: 98  Bit Score: 83.34  E-value: 6.11e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   189 CCQEKGISPLCRGMCKPSEMDQ---HHFDPTSCKtDDYKHFLSCATedGTRSHVHCCKTQLVPSFCYDFCSG------DF 259
Cdd:pfam01682    1 CCSEKGVPSSCLSLCSYDAINKdalLLFLAPRCP-PELPKILRCAA--DGRDHTPCCKRRGVPDKCLGFCPGnvdllsDV 77

                           90       100
                   ....*....|....*....|.
gi 225878001   260 QMLRRSHRLCLYYLPEIFSCL 280
Cdd:pfam01682   78 TPLDKSYLFCLSYFENIKQCF 98
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 484-577 7.11e-17

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


:

Pssm-ID: 460293  Cd Length: 98  Bit Score: 77.56  E-value: 7.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   484 CCTDANVTSFCSSkMCNVAEDPSSFSTITIATTCRAEWPKVSPCIADGRNHTDCCLKKGVQHDCLEICSGSTKELGVHS- 562
Cdd:pfam01682    1 CCSEKGVPSSCLS-LCSYDAINKDALLLFLAPRCPPELPKILRCAADGRDHTPCCKRRGVPDKCLGFCPGNVDLLSDVTp 79

                           90       100
                   ....*....|....*....|
gi 225878001   563 -----VLCLNlDLQAIYQCI 577
Cdd:pfam01682   80 ldksyLFCLS-YFENIKQCF 98
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 825-911 3.30e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.53  E-value: 3.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  825 PAAVRNVEVSSISKDSATISWE---DLEANIIVFRVQLFEKGGN---LIKTENSSADIFRFIDLEPNKDYSVRVTAINFL 898
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGdwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 225878001  899 GEGPPSWNATFTT 911
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 585-675 4.13e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 4.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  585 PSAPGNVTISELTAHSVTVQWTEPNSNAHLVENYTLFIRKNEHGEAVR-TVKNVISPHVEL-GLDPDSEYVLTLQSHSAN 662
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLtGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 225878001  663 GTSLPSTAKLFST 675
Cdd:cd00063    81 GESPPSESVTVTT 93
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 1223-1306 5.10e-15

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


:

Pssm-ID: 460293  Cd Length: 98  Bit Score: 72.17  E-value: 5.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  1223 CCEDEGITGDCLQACNIGR----TSLSIKNQNCTRFAVSLLKCASDIRDHSDCCIASGVTSKCLPLCSGDSFSP------ 1292
Cdd:pfam01682    1 CCSEKGVPSSCLSLCSYDAinkdALLLFLAPRCPPELPKILRCAADGRDHTPCCKRRGVPDKCLGFCPGNVDLLsdvtpl 80

                           90
                   ....*....|....*..
gi 225878001  1293 ---DIDCSEHAVSIMTC 1306
Cdd:pfam01682   81 dksYLFCLSYFENIKQC 97
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 737-817 8.45e-13

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


:

Pssm-ID: 460293  Cd Length: 98  Bit Score: 65.62  E-value: 8.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   737 CCKEQKMPESCMSSCQYNMT--------LPESCKENLNTWVQCASEGHDHLRCCLQEEVSKPCQTACM---------HPF 799
Cdd:pfam01682    1 CCSEKGVPSSCLSLCSYDAInkdalllfLAPRCPPELPKILRCAADGRDHTPCCKRRGVPDKCLGFCPgnvdllsdvTPL 80

                           90
                   ....*....|....*...
gi 225878001   800 TVPADECFSEVSKYRTCF 817
Cdd:pfam01682   81 DKSYLFCLSYFENIKQCF 98
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
823-1025 8.64e-10

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.48  E-value: 8.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  823 ALPAAVRNVEVSSISKDSATISWEDLEANIIVFRVQLFEKGGNLIKTENSSADIFrFIDLEPNKDYSVRVTAINFLGEGP 902
Cdd:COG3401   141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDG-GGDIEPGTTYYYRVAATDTGGESA 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  903 PSWNATFTTKPAQiyegdrPVAPEKLRISWNSGPRVNVTWDPVSvrrnAEVVTkpiEYTIYYlDTEQSSTWTTL-RTNQT 981
Cdd:COG3401   220 PSNEVSVTTPTTP------PSAPTGLTATADTPGSVTLSWDPVT----ESDAT---GYRVYR-SNSGDGPFTKVaTVTTT 285

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 225878001  982 WVVMRDLRKDALYYVYVTAK-EDNRTSRSSSIITILAQKDSPGLP 1025
Cdd:COG3401   286 SYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAAP 330
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1117-1197 3.58e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20946:

Pssm-ID: 472250  Cd Length: 102  Bit Score: 47.15  E-value: 3.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001 1117 SVTMKKDKIRVLDDQSVEIECIYRGGGLDPKISFEKDGKKASRGFLNLKKTEAGYV-------AKWHIRKVKQEDAGFYK 1189
Cdd:cd20946     1 TVPSSQQVVTVVENQEVILSCKTPKKTSSPRVEWKKLQRDVTFVVFQNNKIQGDYKgraeilgTNITIKNVTRSDSGKYR 80


                  ....*...
gi 225878001 1190 CVVTSSDG 1197
Cdd:cd20946    81 CEVSARSD 88
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 413-467 1.24e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 1.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 225878001  413 TNSTTIREFAFQNVNTTErcVTLSDLRSSTRYIVYVTARNEYGTSVPSVRNIAST 467
Cdd:cd00063    41 KGSGDWKEVEVTPGSETS--YTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1315-1392 3.97e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 3.97e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   1315 PSEVSNVRIKA-SEGKVNIEWDYPLTKDYKYFAVYYRKA-HDDHEDWHKLKTIQQNIELDVD---PSEDYEVGILAANAL 1389
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIVGYRVEyREEGSEWKEVNVTPSSTSYTLTglkPGTEYEFRVRAVNGA 80


                    ...
gi 225878001   1390 GHS 1392
Cdd:smart00060   81 GEG 83
WR1 smart00289
Worm-specific repeat type 1; Worm-specific repeat type 1. Cysteine-rich domain apparently ...
 682-724 5.85e-04

Worm-specific repeat type 1; Worm-specific repeat type 1. Cysteine-rich domain apparently unique (so far) to C. elegans. Often appears with KU domains. About 3 dozen worm proteins contain this domain.


:

Pssm-ID: 214601  Cd Length: 38  Bit Score: 38.74  E-value: 5.85e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 225878001    682 PLCTIGEPiymNDGRVMICDAVNPCPNGFRCTGAGSdlSYCCP 724
Cdd:smart00289    1 PVCPNGSD---LGGSPVRCSPNGSCPSGYSCQNSKQ--GICCP 38
 
Name Accession Description Interval E-value
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 189-280 6.11e-19

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


Pssm-ID: 460293  Cd Length: 98  Bit Score: 83.34  E-value: 6.11e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   189 CCQEKGISPLCRGMCKPSEMDQ---HHFDPTSCKtDDYKHFLSCATedGTRSHVHCCKTQLVPSFCYDFCSG------DF 259
Cdd:pfam01682    1 CCSEKGVPSSCLSLCSYDAINKdalLLFLAPRCP-PELPKILRCAA--DGRDHTPCCKRRGVPDKCLGFCPGnvdllsDV 77

                           90       100
                   ....*....|....*....|.
gi 225878001   260 QMLRRSHRLCLYYLPEIFSCL 280
Cdd:pfam01682   78 TPLDKSYLFCLSYFENIKQCF 98
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 484-577 7.11e-17

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


Pssm-ID: 460293  Cd Length: 98  Bit Score: 77.56  E-value: 7.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   484 CCTDANVTSFCSSkMCNVAEDPSSFSTITIATTCRAEWPKVSPCIADGRNHTDCCLKKGVQHDCLEICSGSTKELGVHS- 562
Cdd:pfam01682    1 CCSEKGVPSSCLS-LCSYDAINKDALLLFLAPRCPPELPKILRCAADGRDHTPCCKRRGVPDKCLGFCPGNVDLLSDVTp 79

                           90       100
                   ....*....|....*....|
gi 225878001   563 -----VLCLNlDLQAIYQCI 577
Cdd:pfam01682   80 ldksyLFCLS-YFENIKQCF 98
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 825-911 3.30e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.53  E-value: 3.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  825 PAAVRNVEVSSISKDSATISWE---DLEANIIVFRVQLFEKGGN---LIKTENSSADIFRFIDLEPNKDYSVRVTAINFL 898
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGdwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 225878001  899 GEGPPSWNATFTT 911
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 585-675 4.13e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 4.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  585 PSAPGNVTISELTAHSVTVQWTEPNSNAHLVENYTLFIRKNEHGEAVR-TVKNVISPHVEL-GLDPDSEYVLTLQSHSAN 662
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLtGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 225878001  663 GTSLPSTAKLFST 675
Cdd:cd00063    81 GESPPSESVTVTT 93
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 1223-1306 5.10e-15

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


Pssm-ID: 460293  Cd Length: 98  Bit Score: 72.17  E-value: 5.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  1223 CCEDEGITGDCLQACNIGR----TSLSIKNQNCTRFAVSLLKCASDIRDHSDCCIASGVTSKCLPLCSGDSFSP------ 1292
Cdd:pfam01682    1 CCSEKGVPSSCLSLCSYDAinkdALLLFLAPRCPPELPKILRCAADGRDHTPCCKRRGVPDKCLGFCPGNVDLLsdvtpl 80

                           90
                   ....*....|....*..
gi 225878001  1293 ---DIDCSEHAVSIMTC 1306
Cdd:pfam01682   81 dksYLFCLSYFENIKQC 97
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 737-817 8.45e-13

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


Pssm-ID: 460293  Cd Length: 98  Bit Score: 65.62  E-value: 8.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   737 CCKEQKMPESCMSSCQYNMT--------LPESCKENLNTWVQCASEGHDHLRCCLQEEVSKPCQTACM---------HPF 799
Cdd:pfam01682    1 CCSEKGVPSSCLSLCSYDAInkdalllfLAPRCPPELPKILRCAADGRDHTPCCKRRGVPDKCLGFCPgnvdllsdvTPL 80

                           90
                   ....*....|....*...
gi 225878001   800 TVPADECFSEVSKYRTCF 817
Cdd:pfam01682   81 DKSYLFCLSYFENIKQCF 98
fn3 pfam00041
Fibronectin type III domain;
827-904 1.06e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   827 AVRNVEVSSISKDSATISWE---DLEANIIVFRVQLFEKGGNLIKTE-NSSADIFRFI--DLEPNKDYSVRVTAINFLGE 900
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEiTVPGTTTSVTltGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 225878001   901 GPPS 904
Cdd:pfam00041   82 GPPS 85
fn3 pfam00041
Fibronectin type III domain;
586-668 6.27e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 6.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   586 SAPGNVTISELTAHSVTVQWTEPNSNAHLVENYTLFIRKNEHGEAVRTVKNVISPH-VEL-GLDPDSEYVLTLQSHSANG 663
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTsVTLtGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 225878001   664 TSLPS 668
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 825-901 1.10e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 1.10e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001    825 PAAVRNVEVSSISKDSATISWEDLEAN-----IIVFRVQLFEKGGNLIKTENSSAD-IFRFIDLEPNKDYSVRVTAINFL 898
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 225878001    899 GEG 901
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 585-665 6.67e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 6.67e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001    585 PSAPGNVTISELTAHSVTVQWTEPNSNAHLVENYTLFIRKNEHGEAVRTVK-NVISPHVEL-GLDPDSEYVLTLQSHSAN 662
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNvTPSSTSYTLtGLKPGTEYEFRVRAVNGA 80


                    ...
gi 225878001    663 GTS 665
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
823-1025 8.64e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.48  E-value: 8.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  823 ALPAAVRNVEVSSISKDSATISWEDLEANIIVFRVQLFEKGGNLIKTENSSADIFrFIDLEPNKDYSVRVTAINFLGEGP 902
Cdd:COG3401   141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDG-GGDIEPGTTYYYRVAATDTGGESA 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  903 PSWNATFTTKPAQiyegdrPVAPEKLRISWNSGPRVNVTWDPVSvrrnAEVVTkpiEYTIYYlDTEQSSTWTTL-RTNQT 981
Cdd:COG3401   220 PSNEVSVTTPTTP------PSAPTGLTATADTPGSVTLSWDPVT----ESDAT---GYRVYR-SNSGDGPFTKVaTVTTT 285

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 225878001  982 WVVMRDLRKDALYYVYVTAK-EDNRTSRSSSIITILAQKDSPGLP 1025
Cdd:COG3401   286 SYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAAP 330
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 922-1015 9.30e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 9.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  922 PVAPEKLRISWNSGPRVNVTWDPVSvrrnaEVVTKPIEYTIYY--LDTEQSSTWTTLRTNQTWVVMRDLRKDALYYVYVT 999
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPE-----DDGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*.
gi 225878001 1000 AKEDNRTSRSSSIITI 1015
Cdd:cd00063    76 AVNGGGESPPSESVTV 91
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
823-984 1.44e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.08  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  823 ALPAAVRNVEVSSISKDSATISWED----LEANIIVFRVQlfEKGGNLIK-TENSSADIFRFIDLEPNKDYSVRVTAINF 897
Cdd:COG3401   325 TPPAAPSGLTATAVGSSSITLSWTAssdaDVTGYNVYRST--SGGGTYTKiAETVTTTSYTDTGLTPGTTYYYKVTAVDA 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  898 LG-EGPPSWNATFTTKPAQIYEG-DRPVAPEKLRISWNSGPRVNVTWDPVSVRRNAEVVTKPIEYTIYYLDTEQSSTWTT 975
Cdd:COG3401   403 AGnESAPSEEVSATTASAASGESlTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTT 482


                  ....*....
gi 225878001  976 LRTNQTWVV 984
Cdd:COG3401   483 DTTTANLSV 491
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 922-1001 2.95e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 2.95e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001    922 PVAPEKLRISWNSGPRVNVTWDPVSVRRNAEVVtkpIEYTIYYldTEQSSTWTTLRTN--QTWVVMRDLRKDALYYVYVT 999
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYI---VGYRVEY--REEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVR 75


                    ..
gi 225878001   1000 AK 1001
Cdd:smart00060   76 AV 77
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 1117-1197 3.58e-06

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 47.15  E-value: 3.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001 1117 SVTMKKDKIRVLDDQSVEIECIYRGGGLDPKISFEKDGKKASRGFLNLKKTEAGYV-------AKWHIRKVKQEDAGFYK 1189
Cdd:cd20946     1 TVPSSQQVVTVVENQEVILSCKTPKKTSSPRVEWKKLQRDVTFVVFQNNKIQGDYKgraeilgTNITIKNVTRSDSGKYR 80


                  ....*...
gi 225878001 1190 CVVTSSDG 1197
Cdd:cd20946    81 CEVSARSD 88
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
583-679 2.33e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.85  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  583 THPSAPGNVTISELTAHSVTVQWTePNSNAHlVENYTLFIRKNEHGEAVR--TVKNviSPHVELGLDPDSEYVLTLQSHS 660
Cdd:COG3401   231 TPPSAPTGLTATADTPGSVTLSWD-PVTESD-ATGYRVYRSNSGDGPFTKvaTVTT--TSYTDTGLTNGTTYYYRVTAVD 306

                          90       100
                  ....*....|....*....|...
gi 225878001  661 ANGT-SLPS---TAKLFSTLPTT 679
Cdd:COG3401   307 AAGNeSAPSnvvSVTTDLTPPAA 329
I-set pfam07679
Immunoglobulin I-set domain;
1125-1207 3.88e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.79  E-value: 3.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  1125 IRVLDDQSVEIECIYRGGGlDPKISFEKDGK--KASRGFlnlKKTEAGYVAKWHIRKVKQEDAGFYKCVVTSSDGSrVEA 1202
Cdd:pfam07679   10 VEVQEGESARFTCTVTGTP-DPEVSWFKDGQplRSSDRF---KVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGE-AEA 84


                   ....*
gi 225878001  1203 SSEVI 1207
Cdd:pfam07679   85 SAELT 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 413-467 1.24e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 1.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 225878001  413 TNSTTIREFAFQNVNTTErcVTLSDLRSSTRYIVYVTARNEYGTSVPSVRNIAST 467
Cdd:cd00063    41 KGSGDWKEVEVTPGSETS--YTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1131-1198 3.17e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 3.17e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225878001   1131 QSVEIECIYRGGGlDPKISFEKDGKKASRGFLNLKKTEAGYVAKWHIRKVKQEDAGFYKCVVTSSDGS 1198
Cdd:smart00410   10 ESVTLSCEASGSP-PPEVTWYKQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGS 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1315-1392 3.97e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 3.97e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   1315 PSEVSNVRIKA-SEGKVNIEWDYPLTKDYKYFAVYYRKA-HDDHEDWHKLKTIQQNIELDVD---PSEDYEVGILAANAL 1389
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIVGYRVEyREEGSEWKEVNVTPSSTSYTLTglkPGTEYEFRVRAVNGA 80


                    ...
gi 225878001   1390 GHS 1392
Cdd:smart00060   81 GEG 83
WR1 smart00289
Worm-specific repeat type 1; Worm-specific repeat type 1. Cysteine-rich domain apparently ...
 682-724 5.85e-04

Worm-specific repeat type 1; Worm-specific repeat type 1. Cysteine-rich domain apparently unique (so far) to C. elegans. Often appears with KU domains. About 3 dozen worm proteins contain this domain.


Pssm-ID: 214601  Cd Length: 38  Bit Score: 38.74  E-value: 5.85e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 225878001    682 PLCTIGEPiymNDGRVMICDAVNPCPNGFRCTGAGSdlSYCCP 724
Cdd:smart00289    1 PVCPNGSD---LGGSPVRCSPNGSCPSGYSCQNSKQ--GICCP 38
fn3 pfam00041
Fibronectin type III domain;
424-460 3.08e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 3.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 225878001   424 QNVNTTERCVTLSDLRSSTRYIVYVTARNEYGTSVPS 460
Cdd:pfam00041   49 ITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 412-457 5.33e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 5.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 225878001    412 VTNSTTIREFAFQNVNTTERCVTLSDLRSSTRYIVYVTARNEYGTS 457
Cdd:smart00060   38 VEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 189-280 6.11e-19

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


Pssm-ID: 460293  Cd Length: 98  Bit Score: 83.34  E-value: 6.11e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   189 CCQEKGISPLCRGMCKPSEMDQ---HHFDPTSCKtDDYKHFLSCATedGTRSHVHCCKTQLVPSFCYDFCSG------DF 259
Cdd:pfam01682    1 CCSEKGVPSSCLSLCSYDAINKdalLLFLAPRCP-PELPKILRCAA--DGRDHTPCCKRRGVPDKCLGFCPGnvdllsDV 77

                           90       100
                   ....*....|....*....|.
gi 225878001   260 QMLRRSHRLCLYYLPEIFSCL 280
Cdd:pfam01682   78 TPLDKSYLFCLSYFENIKQCF 98
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 484-577 7.11e-17

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


Pssm-ID: 460293  Cd Length: 98  Bit Score: 77.56  E-value: 7.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   484 CCTDANVTSFCSSkMCNVAEDPSSFSTITIATTCRAEWPKVSPCIADGRNHTDCCLKKGVQHDCLEICSGSTKELGVHS- 562
Cdd:pfam01682    1 CCSEKGVPSSCLS-LCSYDAINKDALLLFLAPRCPPELPKILRCAADGRDHTPCCKRRGVPDKCLGFCPGNVDLLSDVTp 79

                           90       100
                   ....*....|....*....|
gi 225878001   563 -----VLCLNlDLQAIYQCI 577
Cdd:pfam01682   80 ldksyLFCLS-YFENIKQCF 98
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 825-911 3.30e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.53  E-value: 3.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  825 PAAVRNVEVSSISKDSATISWE---DLEANIIVFRVQLFEKGGN---LIKTENSSADIFRFIDLEPNKDYSVRVTAINFL 898
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGdwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 225878001  899 GEGPPSWNATFTT 911
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 585-675 4.13e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 4.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  585 PSAPGNVTISELTAHSVTVQWTEPNSNAHLVENYTLFIRKNEHGEAVR-TVKNVISPHVEL-GLDPDSEYVLTLQSHSAN 662
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLtGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 225878001  663 GTSLPSTAKLFST 675
Cdd:cd00063    81 GESPPSESVTVTT 93
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 1223-1306 5.10e-15

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


Pssm-ID: 460293  Cd Length: 98  Bit Score: 72.17  E-value: 5.10e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  1223 CCEDEGITGDCLQACNIGR----TSLSIKNQNCTRFAVSLLKCASDIRDHSDCCIASGVTSKCLPLCSGDSFSP------ 1292
Cdd:pfam01682    1 CCSEKGVPSSCLSLCSYDAinkdALLLFLAPRCPPELPKILRCAADGRDHTPCCKRRGVPDKCLGFCPGNVDLLsdvtpl 80

                           90
                   ....*....|....*..
gi 225878001  1293 ---DIDCSEHAVSIMTC 1306
Cdd:pfam01682   81 dksYLFCLSYFENIKQC 97
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 737-817 8.45e-13

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


Pssm-ID: 460293  Cd Length: 98  Bit Score: 65.62  E-value: 8.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   737 CCKEQKMPESCMSSCQYNMT--------LPESCKENLNTWVQCASEGHDHLRCCLQEEVSKPCQTACM---------HPF 799
Cdd:pfam01682    1 CCSEKGVPSSCLSLCSYDAInkdalllfLAPRCPPELPKILRCAADGRDHTPCCKRRGVPDKCLGFCPgnvdllsdvTPL 80

                           90
                   ....*....|....*...
gi 225878001   800 TVPADECFSEVSKYRTCF 817
Cdd:pfam01682   81 DKSYLFCLSYFENIKQCF 98
fn3 pfam00041
Fibronectin type III domain;
827-904 1.06e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   827 AVRNVEVSSISKDSATISWE---DLEANIIVFRVQLFEKGGNLIKTE-NSSADIFRFI--DLEPNKDYSVRVTAINFLGE 900
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEiTVPGTTTSVTltGLKPGTEYEVRVQAVNGGGE 81


                   ....
gi 225878001   901 GPPS 904
Cdd:pfam00041   82 GPPS 85
fn3 pfam00041
Fibronectin type III domain;
586-668 6.27e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.12  E-value: 6.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   586 SAPGNVTISELTAHSVTVQWTEPNSNAHLVENYTLFIRKNEHGEAVRTVKNVISPH-VEL-GLDPDSEYVLTLQSHSANG 663
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTsVTLtGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 225878001   664 TSLPS 668
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 825-901 1.10e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 1.10e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001    825 PAAVRNVEVSSISKDSATISWEDLEAN-----IIVFRVQLFEKGGNLIKTENSSAD-IFRFIDLEPNKDYSVRVTAINFL 898
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 225878001    899 GEG 901
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 585-665 6.67e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 6.67e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001    585 PSAPGNVTISELTAHSVTVQWTEPNSNAHLVENYTLFIRKNEHGEAVRTVK-NVISPHVEL-GLDPDSEYVLTLQSHSAN 662
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNvTPSSTSYTLtGLKPGTEYEFRVRAVNGA 80


                    ...
gi 225878001    663 GTS 665
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
823-1025 8.64e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 63.48  E-value: 8.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  823 ALPAAVRNVEVSSISKDSATISWEDLEANIIVFRVQLFEKGGNLIKTENSSADIFrFIDLEPNKDYSVRVTAINFLGEGP 902
Cdd:COG3401   141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDG-GGDIEPGTTYYYRVAATDTGGESA 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  903 PSWNATFTTKPAQiyegdrPVAPEKLRISWNSGPRVNVTWDPVSvrrnAEVVTkpiEYTIYYlDTEQSSTWTTL-RTNQT 981
Cdd:COG3401   220 PSNEVSVTTPTTP------PSAPTGLTATADTPGSVTLSWDPVT----ESDAT---GYRVYR-SNSGDGPFTKVaTVTTT 285

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 225878001  982 WVVMRDLRKDALYYVYVTAK-EDNRTSRSSSIITILAQKDSPGLP 1025
Cdd:COG3401   286 SYTDTGLTNGTTYYYRVTAVdAAGNESAPSNVVSVTTDLTPPAAP 330
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 922-1015 9.30e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 9.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  922 PVAPEKLRISWNSGPRVNVTWDPVSvrrnaEVVTKPIEYTIYY--LDTEQSSTWTTLRTNQTWVVMRDLRKDALYYVYVT 999
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPE-----DDGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVR 75

                          90
                  ....*....|....*.
gi 225878001 1000 AKEDNRTSRSSSIITI 1015
Cdd:cd00063    76 AVNGGGESPPSESVTV 91
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
831-998 7.26e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 54.18  E-value: 7.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  831 VEVSSISKDSATISWeDLEANIIVFRVQLFEKGGNLIKTENSSADIFRFIDLEPNkDYSVRVTAINFLG-EGPPSWNATF 909
Cdd:COG4733   544 VVAQGTAVTTLTVSW-DAPAGAVAYEVEWRRDDGNWVSVPRTSGTSFEVPGIYAG-DYEVRVRAINALGvSSAWAASSET 621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  910 TTKpaqiyeGDRPVAPEKLRISWNSGPR-VNVTWDPVSvrrNAEVVTkpieYTIYY---LDTEQSSTWTTLRTNQTWVVM 985
Cdd:COG4733   622 TVT------GKTAPPPAPTGLTATGGLGgITLSWSFPV---DADTLR----TEIRYsttGDWASATVAQALYPGNTYTLA 688

                         170
                  ....*....|...
gi 225878001  986 rDLRKDALYYVYV 998
Cdd:COG4733   689 -GLKAGQTYYYRA 700
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
823-984 1.44e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 53.08  E-value: 1.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  823 ALPAAVRNVEVSSISKDSATISWED----LEANIIVFRVQlfEKGGNLIK-TENSSADIFRFIDLEPNKDYSVRVTAINF 897
Cdd:COG3401   325 TPPAAPSGLTATAVGSSSITLSWTAssdaDVTGYNVYRST--SGGGTYTKiAETVTTTSYTDTGLTPGTTYYYKVTAVDA 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  898 LG-EGPPSWNATFTTKPAQIYEG-DRPVAPEKLRISWNSGPRVNVTWDPVSVRRNAEVVTKPIEYTIYYLDTEQSSTWTT 975
Cdd:COG3401   403 AGnESAPSEEVSATTASAASGESlTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTT 482


                  ....*....
gi 225878001  976 LRTNQTWVV 984
Cdd:COG3401   483 DTTTANLSV 491
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 922-1001 2.95e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 2.95e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001    922 PVAPEKLRISWNSGPRVNVTWDPVSVRRNAEVVtkpIEYTIYYldTEQSSTWTTLRTN--QTWVVMRDLRKDALYYVYVT 999
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYI---VGYRVEY--REEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVR 75


                    ..
gi 225878001   1000 AK 1001
Cdd:smart00060   76 AV 77
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 1117-1197 3.58e-06

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 47.15  E-value: 3.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001 1117 SVTMKKDKIRVLDDQSVEIECIYRGGGLDPKISFEKDGKKASRGFLNLKKTEAGYV-------AKWHIRKVKQEDAGFYK 1189
Cdd:cd20946     1 TVPSSQQVVTVVENQEVILSCKTPKKTSSPRVEWKKLQRDVTFVVFQNNKIQGDYKgraeilgTNITIKNVTRSDSGKYR 80


                  ....*...
gi 225878001 1190 CVVTSSDG 1197
Cdd:cd20946    81 CEVSARSD 88
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1133-1203 2.31e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 43.86  E-value: 2.31e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225878001 1133 VEIECIYRGGgLDPKISFEKDGKKASRGFLNLKKTEAGyVAKWHIRKVKQEDAGFYKCVVTSSDGSRVEAS 1203
Cdd:cd00096     1 VTLTCSASGN-PPPTITWYKNGKPLPPSSRDSRRSELG-NGTLTISNVTLEDSGTYTCVASNSAGGSASAS 69
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
583-679 2.33e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.85  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  583 THPSAPGNVTISELTAHSVTVQWTePNSNAHlVENYTLFIRKNEHGEAVR--TVKNviSPHVELGLDPDSEYVLTLQSHS 660
Cdd:COG3401   231 TPPSAPTGLTATADTPGSVTLSWD-PVTESD-ATGYRVYRSNSGDGPFTKvaTVTT--TSYTDTGLTNGTTYYYRVTAVD 306

                          90       100
                  ....*....|....*....|...
gi 225878001  661 ANGT-SLPS---TAKLFSTLPTT 679
Cdd:COG3401   307 AAGNeSAPSnvvSVTTDLTPPAA 329
I-set pfam07679
Immunoglobulin I-set domain;
1125-1207 3.88e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 43.79  E-value: 3.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  1125 IRVLDDQSVEIECIYRGGGlDPKISFEKDGK--KASRGFlnlKKTEAGYVAKWHIRKVKQEDAGFYKCVVTSSDGSrVEA 1202
Cdd:pfam07679   10 VEVQEGESARFTCTVTGTP-DPEVSWFKDGQplRSSDRF---KVTYEGGTYTLTISNVQPDDSGKYTCVATNSAGE-AEA 84


                   ....*
gi 225878001  1203 SSEVI 1207
Cdd:pfam07679   85 SAELT 89
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 1125-1198 5.14e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 43.34  E-value: 5.14e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225878001  1125 IRVLDDQSVEIECIYRGGGLDPKISFEKDGKKASRGFLNLKKTEAGYVAKWHIRKVKQEDAGFYKCVVTSSDGS 1198
Cdd:pfam00047    6 VTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLIESLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGS 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 413-467 1.24e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.48  E-value: 1.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 225878001  413 TNSTTIREFAFQNVNTTErcVTLSDLRSSTRYIVYVTARNEYGTSVPSVRNIAST 467
Cdd:cd00063    41 KGSGDWKEVEVTPGSETS--YTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
585-679 1.31e-04

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 46.30  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001  585 PSAPGNVTISELTAHSVTVQWTEPNSNAHlVENYTLFirKNehGEAVRTVKNVISpHVELGLDPDSEYVLTLQSHSANGT 664
Cdd:COG3979     3 PTAPTGLTASNVTSSSVSLSWDASTDNVG-VTGYDVY--RG--GDQVATVTGLTA-WTVTGLTPGTEYTFTVGACDAAGN 76

                          90
                  ....*....|....*
gi 225878001  665 slPSTAKLFSTLPTT 679
Cdd:COG3979    77 --VSAASGTSTAMFG 89
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 1117-1193 2.14e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.40  E-value: 2.14e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 225878001  1117 SVTMKKDKIRVLDDQSVEIECIYRGGGlDPKISFEKDGKKASRGFLnLKKTEAGYVAKWHIRKVKQEDAGFYKCVVT 1193
Cdd:pfam13927    3 VITVSPSSVTVREGETVTLTCEATGSP-PPTITWYKNGEPISSGST-RSRSLSGSNSTLTISNVTRSDAGTYTCVAS 77
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1131-1198 3.17e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 3.17e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225878001   1131 QSVEIECIYRGGGlDPKISFEKDGKKASRGFLNLKKTEAGYVAKWHIRKVKQEDAGFYKCVVTSSDGS 1198
Cdd:smart00410   10 ESVTLSCEASGSP-PPEVTWYKQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGS 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1315-1392 3.97e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 3.97e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001   1315 PSEVSNVRIKA-SEGKVNIEWDYPLTKDYKYFAVYYRKA-HDDHEDWHKLKTIQQNIELDVD---PSEDYEVGILAANAL 1389
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIVGYRVEyREEGSEWKEVNVTPSSTSYTLTglkPGTEYEFRVRAVNGA 80


                    ...
gi 225878001   1390 GHS 1392
Cdd:smart00060   81 GEG 83
WR1 smart00289
Worm-specific repeat type 1; Worm-specific repeat type 1. Cysteine-rich domain apparently ...
 682-724 5.85e-04

Worm-specific repeat type 1; Worm-specific repeat type 1. Cysteine-rich domain apparently unique (so far) to C. elegans. Often appears with KU domains. About 3 dozen worm proteins contain this domain.


Pssm-ID: 214601  Cd Length: 38  Bit Score: 38.74  E-value: 5.85e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 225878001    682 PLCTIGEPiymNDGRVMICDAVNPCPNGFRCTGAGSdlSYCCP 724
Cdd:smart00289    1 PVCPNGSD---LGGSPVRCSPNGSCPSGYSCQNSKQ--GICCP 38
IgI_2_Robo cd05724
Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of ...
 1126-1207 1.51e-03

Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of the Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (Robo1, Robo2, and Robo3), and three mammalian Slit homologs (Slit-1,Slit-2, Slit-3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. Robo1, Robo2, and Robo3 are expressed by commissural neurons in the vertebrate spinal cord and Slit-1, Slit-2, Slit-3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of Slit responsiveness, antagonizes Slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit-2 has been shown by surface plasmon resonance experiments and mutational analysis to be the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409389 [Multi-domain]  Cd Length: 87  Bit Score: 39.31  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225878001 1126 RVLDDQSVEIECIYRGGGLDPKISFEKDGKKasrgfLNLKKTEAGYV--AKWHIRKVKQEDAGFYKCVVTSSDGSRVEAS 1203
Cdd:cd05724     8 QVAVGEMAVLECSPPRGHPEPTVSWRKDGQP-----LNLDNERVRIVddGNLLIAEARKSDEGTYKCVATNMVGERESRA 82


                  ....
gi 225878001 1204 SEVI 1207
Cdd:cd05724    83 ARLS 86
DB pfam01682
DB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 185-229 3.03e-03

DB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig pfam00047 and fn3 pfam00041 domains, as well as in some lipases pfam00657.


Pssm-ID: 460293  Cd Length: 98  Bit Score: 38.66  E-value: 3.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 225878001   185 DHSECCQEKGISPLCRGMCKPSEMDQHHFDPTscktddYKHFLSC 229
Cdd:pfam01682   49 DHTPCCKRRGVPDKCLGFCPGNVDLLSDVTPL------DKSYLFC 87
fn3 pfam00041
Fibronectin type III domain;
424-460 3.08e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.16  E-value: 3.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 225878001   424 QNVNTTERCVTLSDLRSSTRYIVYVTARNEYGTSVPS 460
Cdd:pfam00041   49 ITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 412-457 5.33e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.59  E-value: 5.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 225878001    412 VTNSTTIREFAFQNVNTTERCVTLSDLRSSTRYIVYVTARNEYGTS 457
Cdd:smart00060   38 VEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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