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Conserved domains on  [gi|212288695|emb|CAS01787|]
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unnamed protein product [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.65e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.65e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 212288695    3 SVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-633 2.52e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 249 KPYECKQCGKAFSCPTYFRTHERTHTGEKPYKC--KECGKAFSFLSSFRRHKRTHSGEKPYEC-KECGKAFFYSASFRAH 325
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 326 VIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSI-SLRLHERTHTGEkpyeckQCHKTFSFSS 404
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANS------LSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 405 SLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERtHNAEKPYECKQCGKAFRCSSYFRIH------ERSHTGEKPYECK 478
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 479 QCGKVFIRSSSFRLHERTHTG-EKPYECKLCGKTFSFSSSLREH--EKIHTG--NKPFEC--KQCGKAFLRSSQIRLHER 551
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 552 THTGEKPYQCK-------------------------------------QCGKAFISSSKFRMHERTHTGEKP--YRCKQC 592
Cdd:COG5048  345 LHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 212288695 593 GKAFRFSSSVRIHERSHTGEKPYECKQCGKaFISSSHFRLH 633
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
156-180 9.17e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.17e-03
                          10        20
                  ....*....|....*....|....*
gi 212288695  156 FRKHERTHTGVKPYECKQCGKAFIY 180
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.65e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.65e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 212288695    3 SVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 1.24e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 1.24e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 212288695     4 VSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 4.03e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.20  E-value: 4.03e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 212288695   4 VSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLV 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-633 2.52e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 249 KPYECKQCGKAFSCPTYFRTHERTHTGEKPYKC--KECGKAFSFLSSFRRHKRTHSGEKPYEC-KECGKAFFYSASFRAH 325
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 326 VIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSI-SLRLHERTHTGEkpyeckQCHKTFSFSS 404
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANS------LSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 405 SLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERtHNAEKPYECKQCGKAFRCSSYFRIH------ERSHTGEKPYECK 478
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 479 QCGKVFIRSSSFRLHERTHTG-EKPYECKLCGKTFSFSSSLREH--EKIHTG--NKPFEC--KQCGKAFLRSSQIRLHER 551
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 552 THTGEKPYQCK-------------------------------------QCGKAFISSSKFRMHERTHTGEKP--YRCKQC 592
Cdd:COG5048  345 LHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 212288695 593 GKAFRFSSSVRIHERSHTGEKPYECKQCGKaFISSSHFRLH 633
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-262 6.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 212288695  237 SFQRHKRTHTGEKPYECKQCGKAFSC 262
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
156-180 9.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.17e-03
                          10        20
                  ....*....|....*....|....*
gi 212288695  156 FRKHERTHTGVKPYECKQCGKAFIY 180
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.65e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.53  E-value: 1.65e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 212288695    3 SVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-46 1.24e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 1.24e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 212288695     4 VSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLGKK 46
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 4.03e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.20  E-value: 4.03e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 212288695   4 VSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLV 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-633 2.52e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 2.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 249 KPYECKQCGKAFSCPTYFRTHERTHTGEKPYKC--KECGKAFSFLSSFRRHKRTHSGEKPYEC-KECGKAFFYSASFRAH 325
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 326 VIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSI-SLRLHERTHTGEkpyeckQCHKTFSFSS 404
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANS------LSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 405 SLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERtHNAEKPYECKQCGKAFRCSSYFRIH------ERSHTGEKPYECK 478
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 479 QCGKVFIRSSSFRLHERTHTG-EKPYECKLCGKTFSFSSSLREH--EKIHTG--NKPFEC--KQCGKAFLRSSQIRLHER 551
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 552 THTGEKPYQCK-------------------------------------QCGKAFISSSKFRMHERTHTGEKP--YRCKQC 592
Cdd:COG5048  345 LHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 212288695 593 GKAFRFSSSVRIHERSHTGEKPYECKQCGKaFISSSHFRLH 633
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
101-606 2.47e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 2.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 101 KPHECSFCGRDFIHHSSLNRHMRSHTGQKPneyqeyekqpckckavgktfsyHHCFRkherthtgvkpyecKQCGKAFIY 180
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKP----------------------SQCSY--------------SGCDKSFSR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 181 YQPFQRHERTHAGQKPYECKQCGKTFIYYQSFQKHAHTGKKPYE---CKQCGKAFICYQSFQRHKRTHTGEKPYECKQC- 256
Cdd:COG5048   76 PLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNn 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 257 GKAFSCPTYFRTHERTHTGEKpykckeCGKAFSFLSSFRRHKRTHSGEKPYECKECGKAFFYSASFRAHVIIHtgarpyk 336
Cdd:COG5048  156 SSSVNTPQSNSLHPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLEN------- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 337 ckecgkaFNSSNSCrvHERTHIGEKPYecKRCGKSFSWSISLRLHERTHtgekpYECKQCHKTFSFSSSLREHETTHTG- 415
Cdd:COG5048  223 -------SSSSLPL--TTNSQLSPKSL--LSQSPSSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGf 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 416 EKPYECKQCGKTFSFSSSLQRHERTHNaekpyeckqcgkafrcssyfrihersHTGE--KPYEC--KQCGKVFIRSSSFR 491
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRSVN--------------------------HSGEslKPFSCpySLCGKLFSRNDALK 340

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 492 LHERTHTGEKPYECKLCGKTFSFSSSL-------REHEKIHTGNKPFEC--KQCGKAFLRSSQIRLHERTHTGEKPYQCK 562
Cdd:COG5048  341 RHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK 420

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 212288695 563 --QCGKAFISSSKFRMHERTHTGEKPYRCKQCGKAFRFSSSVRIHE 606
Cdd:COG5048  421 npPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-639 6.24e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 6.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 361 KPYECKRCGKSFSWSISLRLHERTHTGEKPYEC--KQCHKTFSFSSSLREHETTHTGEKPYEC-KQCGKTFSFSSSLQRH 437
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 438 ERTHNAEKPYECKQCGKAFRCSSYFRIHERSHTGEKPYECKQCGKVFIRSS----------------------SFRLHER 495
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 496 THTGEKPYECKLCGKTFSFSSSLREHEKIHTGNKPFECKQCGKAFLRSSQIRLHERTHTGEKPYQCKQCG------KAFI 569
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212288695 570 SSSKFRMHERTHTG-EKPYRCKQCGKAFRFSSSVRIHERS--HTGE--KPYEC--KQCGKAFISSSHFRLHERTHMG 639
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-262 6.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 212288695  237 SFQRHKRTHTGEKPYECKQCGKAFSC 262
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
442-630 2.49e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 442 NAEKPYECKQCGKAFRCSSYFRIHERSHTGEKPYEC--KQCGKVFIRSSSFRLHERTHTGEKPYEC-KLCGKTFSFSSSL 518
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212288695 519 REHEKIHTGNKPFECKQCGKAFLRSSQIRLHERTHTGEKPYQCKQC---GKAFISSSKFRM-HERTHTGEKPYRCkqcgk 594
Cdd:COG5048  109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnssSVNTPQSNSLHPpLPANSLSKDPSSN----- 183

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 212288695 595 afrfsSSVRIHERSHTGEKPYECKQCGKAFISSSHF 630
Cdd:COG5048  184 -----LSLLISSNVSTSIPSSSENSPLSSSYSIPSS 214
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-316 2.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.61e-03
                          10        20
                  ....*....|....*....|....
gi 212288695  293 SFRRHKRTHSGEKPYECKECGKAF 316
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-289 2.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.66e-03
                          10        20
                  ....*....|....*....|....*
gi 212288695  265 YFRTHERTHTGEKPYKCKECGKAFS 289
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-401 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*
gi 212288695  377 SLRLHERTHTGEKPYECKQCHKTFS 401
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-596 6.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.25e-03
                          10        20
                  ....*....|....*....|...
gi 212288695  574 FRMHERTHTGEKPYRCKQCGKAF 596
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
433-458 7.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 212288695  433 SLQRHERTHNAEKPYECKQCGKAFRC 458
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-429 7.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.84e-03
                          10        20
                  ....*....|....*....|....*
gi 212288695  405 SLREHETTHTGEKPYECKQCGKTFS 429
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-542 8.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 212288695  517 SLREHEKIHTGNKPFECKQCGKAFLR 542
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
156-180 9.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.17e-03
                          10        20
                  ....*....|....*....|....*
gi 212288695  156 FRKHERTHTGVKPYECKQCGKAFIY 180
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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