|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
46-840 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 979.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 46 FCSSKILFTPQEDDIKtGYTPDGARSLDEIEVFSDFFASTGDPIAVFLFATAKD-NSSMGEYNAMKEVVEILDFVGEN-- 122
Cdd:pfam02460 1 VLSSDIVYTRTPDDAR-SFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGrNSNILDISYLNDIYQLNDYISTNve 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 123 LTHKG--ESFYTMCTDFCQINEPVRQYYNGlaMKQQNLSdvGSRFQLTFPMMQVLGKELDLSPNFFGVRTNEDGEVEYVK 200
Cdd:pfam02460 80 IQVDGiiISFKDLCSRYCDLNCPVNKHYNG--MLLSRRH--NTRIDITYPIMPVLGTPIYLGPHFGGVDFEPPGNISYAK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 201 IIMLQIRANIPKNWKKEDAAEYERMISQYFHFKYNSSHVTPLAMSLTYTGDEVVRTGLTIFPFIGVGFAIMTTFSVITIY 280
Cdd:pfam02460 156 AIVLWYFLKFDEEEVEEDSKEWEDELSQLLHNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 281 YSSSRLDQWTIHKVSEAVLGCVCPLLATSSALGTLFWCGFRFGTILCVTPFLILAIGVDDAYLQIHACMRLTAEDSlmtK 360
Cdd:pfam02460 236 TLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLS---V 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 361 REKIARMLVEVGPSIAITSMTNLLAFLVGIYTPTPEISLFCAGNAVAIGFDFIYQITMYTAILSICENLEMRKN------ 434
Cdd:pfam02460 313 KKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRhclfvw 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 435 ---ATKRKDSDLSFK-----NEQ--FTVMLDSYCDWVANAYTHLLVLFCFIVYIFVSIRGALNINIILSPDKLVIGDSPL 504
Cdd:pfam02460 393 atsSPQRIDSEGSEPdkshnIEQlkSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPL 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 505 LQVNFLRDQFVLPNYTTVNIFVNNPGNLTVQSNLDYMNSLMESFESYPECLGKKFSHYFVRDYESFREssleelemmeDE 584
Cdd:pfam02460 473 VEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFLS----------TL 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 585 QGESNRTSLEPFSKAAMSDFLAWPEFQHWNGFVKFDKNG-MLSRFWATVSyhGEGLGDFQVRRKMLNRWRATADQFAPLN 663
Cdd:pfam02460 543 NMEEEEDEEKEWSYGNLPSFLKAPGNSHWAGDLVWDDNTtMVTKFRFTLA--GKGLSTWNDRTRALQEWRSIADQYPEFN 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 664 VSIFDDYAPFVDTLETILPATISTSVCTLLCMMVVCFLFMYNIFTVFVATLAITSICIGVFGFLSMWGIDLDPISMACTI 743
Cdd:pfam02460 621 VTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITII 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 744 MSIGFSVDFPAHITFHYFREGLHDPQstpaKRVARSLAAIGFPLLQCGISTILFVLCLLFVPTYMGEVFVKTMILVVTLG 823
Cdd:pfam02460 701 MSIGFSVDFSAHIAYHFVRSRGDTPA----ERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIG 776
|
810
....*....|....*..
gi 187035796 824 LIHGLFIVPAFLCAFTA 840
Cdd:pfam02460 777 LLHGLFILPIILSLFVT 793
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
19-838 |
1.73e-30 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 128.82 E-value: 1.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 19 NRFFRQCGLFVADNDKTVLIVTLLLTAFCSSKILFTPQEDDIKTgYTPDGARSLDEIEVFSDFFasTGDPIAVFLFATAK 98
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEF--GGDDTVVVAVEGKD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 99 DNSSMGEYNAMKEVVEILDFVG--ENLTHKGESFYTMCTDFCQINEPVrqyynglamkqqnlsdVGSRFQLTFPMMQVLG 176
Cdd:COG1033 78 DIFTPETLEALRELTEELEEIPgvDSVTSLTNVRATEGTEDGLTVEPL----------------IPDELPASPEELAELR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 177 KELDLSPNFFGVRTNEDGEVEYVkIIMLQIRANIPKNWKKEDAAEYERMISQYfHFKYNSSHVTPLAMSLTYTGDEVVRT 256
Cdd:COG1033 142 EKVLSSPLYVGRLVSPDGKATLI-VVTLDPDPLSSDLDRKEVVAEIRAIIAKY-EDPGVEVYLTGFPVLRGDIAEAIQSD 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 257 GLTIFPFigvgfAIMTTFSVITIYYSSsrldqwtihkVSEAVLGCVCPLLATSSALGTLFWCGFRFGTILCVTPFLILAI 336
Cdd:COG1033 220 LAIFFPL-----ALLLILLLLFLFFRS----------LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAI 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 337 GVDDAylqIHACMRLTAE-DSLMTKREKIARMLVEVGPSIAITSMTNLLAFLVGIYTPTPEISLFcaGNAVAIG--FDFI 413
Cdd:COG1033 285 GIDYG---IHLLNRYREErRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDF--GIVAAIGvlLAFL 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 414 YQITMYTAILSIcenLEMRKNATKRKDSDLSFKNeqftvMLDSYCDWVANAYThlLVLFCFIVYIFVSIRGALNINIILS 493
Cdd:COG1033 360 TSLTLLPALLSL---LPRPKPKTRRLKKPPELGR-----LLAKLARFVLRRPK--VILVVALVLAVVSLYGISRLKVEYD 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 494 PDKLVIGDSPLLQ-VNFLRDQFvlPNYTTVNIFVNNPGNLTVQS--NLDYMNSLMESFESYPEclgkkfshyfVRDYESF 570
Cdd:COG1033 430 FEDYLPEDSPIRQdLDFIEENF--GGSDPLEVVVDTGEPDGLKDpeVLKEIDRLQDYLESLPE----------VGKVLSL 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 571 reSSLEELEMMEDEQGESNRTSL---EPFSKAAMSDFLAWPEFQHwNGFVKFDKNGMlsRFWATVSYHgeglgDFQVRRK 647
Cdd:COG1033 498 --ADLVKELNQALNEGDPKYYALpesRELLAQLLLLLSSPPGDDL-SRFVDEDYSAA--RVTVRLKDL-----DSEEIKA 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 648 MLNRWRATADQFAP---LNVSIFDDYAPFVDTLETILPATISTSVCTLLCMMVVCFLFMYNIFTVFVATLAITSICIGVF 724
Cdd:COG1033 568 LVEEVRAFLAENFPpdgVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTF 647
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 725 GFLSMWGIDLDPISMACTIMSIGFSVDFPAHITFHYFREGLHDPqsTPAKRVARSLAAIGFPLLQCGISTILFVLCLL-- 802
Cdd:COG1033 648 GLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGG--DLEEAIRRALRTTGKAILFTSLTLAAGFGVLLfs 725
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 187035796 803 -FVPT-YMGEVFVKTMI--LVVTlglihgLFIVPAFLCAF 838
Cdd:COG1033 726 sFPPLaDFGLLLALGLLvaLLAA------LLLLPALLLLL 759
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
13-838 |
9.44e-25 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 111.54 E-value: 9.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 13 AFVRLLNRFFRQCGLFVADNDKTVLIVTLLLTAFCSSKILFTPQEDDIKTGYTPDGARSLDEIEVFSDFFAstgdP---I 89
Cdd:TIGR00917 304 TVQGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFG----PfyrI 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 90 AVFLFATAKDNSSMG-----EYNAMKEVVEI--------LDFVGENLTHKGESFYTMCTDFCQINEPVRQYYNGLA-MKQ 155
Cdd:TIGR00917 380 EQLIIATVQTSSHEKapeilTDDNLKLLFDIqkkvsqlfANYEGELITLDSPCFKPNHPYNCFIYSTCKKLQNMYSkLKP 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 156 QNLSDVG---------SRFQLTFPMMQVLGKELDLSPNFFGVRTNEDGEVEYVkIIMLQIRANIPKNWKKEDAAEYERMI 226
Cdd:TIGR00917 460 ENYDDYGgvdyvkycfEHFTSPESCLSAFGGPVDPTTVLGGFSGNNFSEASAF-VVTFPVNNFVNKTNKTEKAVAWEKAF 538
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 227 SQYFHFKYNSShvtpLAMSLTYTG-----DEVVRTGLTIFPFIGVGFAIMTTFSVITIYYSSSRLDQWTIHKVSEAVLGC 301
Cdd:TIGR00917 539 IQLAKDELLPM----VQATISFSAersieDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGLSGI 614
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 302 VCPLLATSSALGTLFWCGFRFGTILC-VTPFLILAIGVDDAYLQIHACMRL--------TAEDSLMTKREKIARMLVEVG 372
Cdd:TIGR00917 615 LIVMLSVLGSVGVFSAVGLKSTLIIMeVIPFLVLAVGVDNIFILVFFYFYLeyfyrqvgVDNEQELTLERRLSRALMEVG 694
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 373 PSIAITSMTNLLAFLVGIYTPTPEISLFCAGNAVAIGFDFIYQITMYTAILSicenLEMRKNATKRKD-------SDLSF 445
Cdd:TIGR00917 695 PSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLV----LDFKRTEDKRVDcfpciktSKSSI 770
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 446 KNEQ----------FTVMLDSYCDWVANAYTHLLVLFCFIVYIFVSIRGALNINIILSpDKLVIGDSPLLQVNFLRDQFV 515
Cdd:TIGR00917 771 SAEKgsgqrkagllTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLD-QQIVLPQDSYLQIYFASLTPL 849
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 516 LPNYTTVNIFVNNPGNLT---VQSNLDYM-----NSLMESFESYPEcLGKKFSHYfVRDYESFRESSLEELEMMEDEQGE 587
Cdd:TIGR00917 850 LEVGPPFYIVIKGDYNYTdfeSQNKLCTMggcdkDSIVNVFNNLSY-IAKPASSW-LDDYLVWLSPQASCCCRKFTNGTF 927
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 588 SNRTSLEPFSKAAMS-DFLAWPEFQHWNGFVKF----------------------DKNGMLSRFWAT--VSYHG--EGLG 640
Cdd:TIGR00917 928 CNGPDPQCFRCADLSsDAQGRPSTTQFKEKLPWflnalpsadcakgghaayssavDLQGYATIIQASsfRTYHTplNTQV 1007
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 641 DFQVRRKMLNRWRATADQFAPLNVSIFDDYAPFVDTLETILPATISTSVCTLLCMMVVC-FLFMYNIFTVFVATLAITSI 719
Cdd:TIGR00917 1008 DFINAMRAAQEFAAKVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVClFLLQLNALSVVNLIMSVGMA 1087
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 720 CIGVFGFLSMWGIDLDPISMACTIMSIGFSVDFPAHITfHYFREGLHDPQSTPAKRVARSLAAIGFPLLQcgISTILFVL 799
Cdd:TIGR00917 1088 VVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHIN-AQFSTGKHFSRNHRAKEALGGMGSSVFSGIT--LTKLVGVV 1164
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 187035796 800 CLLFVPTYMGEVFVKTMIL-VVTLGLIHGLFIVPAFLCAF 838
Cdd:TIGR00917 1165 VLGFSRSEIFVVYYFRMYLaLVLLGFLHGLVFLPVLLSVL 1204
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
669-837 |
1.39e-05 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 49.13 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 669 DYAPFVDTletilpaTISTSVCTLLCMMVVCFLFMYNIFTVFVATL----AITSICIGVFGFLSMWGIDLDPISMACTIM 744
Cdd:PRK15127 328 DTTPFVKI-------SIHEVVKTLVEAIILVFLVMYLFLQNFRATLiptiAVPVVLLGTFAVLAAFGFSINTLTMFGMVL 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 745 SIGFSVDFPAHITFHYFR----EGLhdpqsTPAKRVARSLAAIgfpllQCGISTILFVLCLLFVP-TYMG-------EVF 812
Cdd:PRK15127 401 AIGLLVDDAIVVVENVERvmaeEGL-----PPKEATRKSMGQI-----QGALVGIAMVLSAVFVPmAFFGgstgaiyRQF 470
|
170 180
....*....|....*....|....*
gi 187035796 813 VKTMILVVTLGLIHGLFIVPAfLCA 837
Cdd:PRK15127 471 SITIVSAMALSVLVALILTPA-LCA 494
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
662-813 |
5.39e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 40.38 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 662 LNVSIFDDYAPFVdtlETILPATISTSVCTLLCMMVVCFLFMYNIFTVFVATLAITSICIGVFGFLSMWGIDLDPISMAC 741
Cdd:NF033617 313 IKVNVLYDRTRFI---RASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMA 389
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187035796 742 TIMSIGFSVDfPAHIT----FHYFREGlhDPQSTPAKRVARSlaaIGFPLLQCGISTILFVLCLLFVPTYMGEVFV 813
Cdd:NF033617 390 LVLAIGLVVD-DAIVVveniHRHIEEG--ESPLEAALKGARE---IGFTVIAMTLTLVAVYLPILFMGGLTGRLFR 459
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
46-840 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 979.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 46 FCSSKILFTPQEDDIKtGYTPDGARSLDEIEVFSDFFASTGDPIAVFLFATAKD-NSSMGEYNAMKEVVEILDFVGEN-- 122
Cdd:pfam02460 1 VLSSDIVYTRTPDDAR-SFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGrNSNILDISYLNDIYQLNDYISTNve 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 123 LTHKG--ESFYTMCTDFCQINEPVRQYYNGlaMKQQNLSdvGSRFQLTFPMMQVLGKELDLSPNFFGVRTNEDGEVEYVK 200
Cdd:pfam02460 80 IQVDGiiISFKDLCSRYCDLNCPVNKHYNG--MLLSRRH--NTRIDITYPIMPVLGTPIYLGPHFGGVDFEPPGNISYAK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 201 IIMLQIRANIPKNWKKEDAAEYERMISQYFHFKYNSSHVTPLAMSLTYTGDEVVRTGLTIFPFIGVGFAIMTTFSVITIY 280
Cdd:pfam02460 156 AIVLWYFLKFDEEEVEEDSKEWEDELSQLLHNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 281 YSSSRLDQWTIHKVSEAVLGCVCPLLATSSALGTLFWCGFRFGTILCVTPFLILAIGVDDAYLQIHACMRLTAEDSlmtK 360
Cdd:pfam02460 236 TLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLS---V 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 361 REKIARMLVEVGPSIAITSMTNLLAFLVGIYTPTPEISLFCAGNAVAIGFDFIYQITMYTAILSICENLEMRKN------ 434
Cdd:pfam02460 313 KKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRhclfvw 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 435 ---ATKRKDSDLSFK-----NEQ--FTVMLDSYCDWVANAYTHLLVLFCFIVYIFVSIRGALNINIILSPDKLVIGDSPL 504
Cdd:pfam02460 393 atsSPQRIDSEGSEPdkshnIEQlkSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPL 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 505 LQVNFLRDQFVLPNYTTVNIFVNNPGNLTVQSNLDYMNSLMESFESYPECLGKKFSHYFVRDYESFREssleelemmeDE 584
Cdd:pfam02460 473 VEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFLS----------TL 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 585 QGESNRTSLEPFSKAAMSDFLAWPEFQHWNGFVKFDKNG-MLSRFWATVSyhGEGLGDFQVRRKMLNRWRATADQFAPLN 663
Cdd:pfam02460 543 NMEEEEDEEKEWSYGNLPSFLKAPGNSHWAGDLVWDDNTtMVTKFRFTLA--GKGLSTWNDRTRALQEWRSIADQYPEFN 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 664 VSIFDDYAPFVDTLETILPATISTSVCTLLCMMVVCFLFMYNIFTVFVATLAITSICIGVFGFLSMWGIDLDPISMACTI 743
Cdd:pfam02460 621 VTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITII 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 744 MSIGFSVDFPAHITFHYFREGLHDPQstpaKRVARSLAAIGFPLLQCGISTILFVLCLLFVPTYMGEVFVKTMILVVTLG 823
Cdd:pfam02460 701 MSIGFSVDFSAHIAYHFVRSRGDTPA----ERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIG 776
|
810
....*....|....*..
gi 187035796 824 LIHGLFIVPAFLCAFTA 840
Cdd:pfam02460 777 LLHGLFILPIILSLFVT 793
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
19-838 |
1.73e-30 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 128.82 E-value: 1.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 19 NRFFRQCGLFVADNDKTVLIVTLLLTAFCSSKILFTPQEDDIKTgYTPDGARSLDEIEVFSDFFasTGDPIAVFLFATAK 98
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEF--GGDDTVVVAVEGKD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 99 DNSSMGEYNAMKEVVEILDFVG--ENLTHKGESFYTMCTDFCQINEPVrqyynglamkqqnlsdVGSRFQLTFPMMQVLG 176
Cdd:COG1033 78 DIFTPETLEALRELTEELEEIPgvDSVTSLTNVRATEGTEDGLTVEPL----------------IPDELPASPEELAELR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 177 KELDLSPNFFGVRTNEDGEVEYVkIIMLQIRANIPKNWKKEDAAEYERMISQYfHFKYNSSHVTPLAMSLTYTGDEVVRT 256
Cdd:COG1033 142 EKVLSSPLYVGRLVSPDGKATLI-VVTLDPDPLSSDLDRKEVVAEIRAIIAKY-EDPGVEVYLTGFPVLRGDIAEAIQSD 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 257 GLTIFPFigvgfAIMTTFSVITIYYSSsrldqwtihkVSEAVLGCVCPLLATSSALGTLFWCGFRFGTILCVTPFLILAI 336
Cdd:COG1033 220 LAIFFPL-----ALLLILLLLFLFFRS----------LRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAI 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 337 GVDDAylqIHACMRLTAE-DSLMTKREKIARMLVEVGPSIAITSMTNLLAFLVGIYTPTPEISLFcaGNAVAIG--FDFI 413
Cdd:COG1033 285 GIDYG---IHLLNRYREErRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDF--GIVAAIGvlLAFL 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 414 YQITMYTAILSIcenLEMRKNATKRKDSDLSFKNeqftvMLDSYCDWVANAYThlLVLFCFIVYIFVSIRGALNINIILS 493
Cdd:COG1033 360 TSLTLLPALLSL---LPRPKPKTRRLKKPPELGR-----LLAKLARFVLRRPK--VILVVALVLAVVSLYGISRLKVEYD 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 494 PDKLVIGDSPLLQ-VNFLRDQFvlPNYTTVNIFVNNPGNLTVQS--NLDYMNSLMESFESYPEclgkkfshyfVRDYESF 570
Cdd:COG1033 430 FEDYLPEDSPIRQdLDFIEENF--GGSDPLEVVVDTGEPDGLKDpeVLKEIDRLQDYLESLPE----------VGKVLSL 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 571 reSSLEELEMMEDEQGESNRTSL---EPFSKAAMSDFLAWPEFQHwNGFVKFDKNGMlsRFWATVSYHgeglgDFQVRRK 647
Cdd:COG1033 498 --ADLVKELNQALNEGDPKYYALpesRELLAQLLLLLSSPPGDDL-SRFVDEDYSAA--RVTVRLKDL-----DSEEIKA 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 648 MLNRWRATADQFAP---LNVSIFDDYAPFVDTLETILPATISTSVCTLLCMMVVCFLFMYNIFTVFVATLAITSICIGVF 724
Cdd:COG1033 568 LVEEVRAFLAENFPpdgVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTF 647
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 725 GFLSMWGIDLDPISMACTIMSIGFSVDFPAHITFHYFREGLHDPqsTPAKRVARSLAAIGFPLLQCGISTILFVLCLL-- 802
Cdd:COG1033 648 GLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGG--DLEEAIRRALRTTGKAILFTSLTLAAGFGVLLfs 725
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 187035796 803 -FVPT-YMGEVFVKTMI--LVVTlglihgLFIVPAFLCAF 838
Cdd:COG1033 726 sFPPLaDFGLLLALGLLvaLLAA------LLLLPALLLLL 759
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
13-838 |
9.44e-25 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 111.54 E-value: 9.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 13 AFVRLLNRFFRQCGLFVADNDKTVLIVTLLLTAFCSSKILFTPQEDDIKTGYTPDGARSLDEIEVFSDFFAstgdP---I 89
Cdd:TIGR00917 304 TVQGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFG----PfyrI 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 90 AVFLFATAKDNSSMG-----EYNAMKEVVEI--------LDFVGENLTHKGESFYTMCTDFCQINEPVRQYYNGLA-MKQ 155
Cdd:TIGR00917 380 EQLIIATVQTSSHEKapeilTDDNLKLLFDIqkkvsqlfANYEGELITLDSPCFKPNHPYNCFIYSTCKKLQNMYSkLKP 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 156 QNLSDVG---------SRFQLTFPMMQVLGKELDLSPNFFGVRTNEDGEVEYVkIIMLQIRANIPKNWKKEDAAEYERMI 226
Cdd:TIGR00917 460 ENYDDYGgvdyvkycfEHFTSPESCLSAFGGPVDPTTVLGGFSGNNFSEASAF-VVTFPVNNFVNKTNKTEKAVAWEKAF 538
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 227 SQYFHFKYNSShvtpLAMSLTYTG-----DEVVRTGLTIFPFIGVGFAIMTTFSVITIYYSSSRLDQWTIHKVSEAVLGC 301
Cdd:TIGR00917 539 IQLAKDELLPM----VQATISFSAersieDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGLSGI 614
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 302 VCPLLATSSALGTLFWCGFRFGTILC-VTPFLILAIGVDDAYLQIHACMRL--------TAEDSLMTKREKIARMLVEVG 372
Cdd:TIGR00917 615 LIVMLSVLGSVGVFSAVGLKSTLIIMeVIPFLVLAVGVDNIFILVFFYFYLeyfyrqvgVDNEQELTLERRLSRALMEVG 694
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 373 PSIAITSMTNLLAFLVGIYTPTPEISLFCAGNAVAIGFDFIYQITMYTAILSicenLEMRKNATKRKD-------SDLSF 445
Cdd:TIGR00917 695 PSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLV----LDFKRTEDKRVDcfpciktSKSSI 770
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 446 KNEQ----------FTVMLDSYCDWVANAYTHLLVLFCFIVYIFVSIRGALNINIILSpDKLVIGDSPLLQVNFLRDQFV 515
Cdd:TIGR00917 771 SAEKgsgqrkagllTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLD-QQIVLPQDSYLQIYFASLTPL 849
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 516 LPNYTTVNIFVNNPGNLT---VQSNLDYM-----NSLMESFESYPEcLGKKFSHYfVRDYESFRESSLEELEMMEDEQGE 587
Cdd:TIGR00917 850 LEVGPPFYIVIKGDYNYTdfeSQNKLCTMggcdkDSIVNVFNNLSY-IAKPASSW-LDDYLVWLSPQASCCCRKFTNGTF 927
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 588 SNRTSLEPFSKAAMS-DFLAWPEFQHWNGFVKF----------------------DKNGMLSRFWAT--VSYHG--EGLG 640
Cdd:TIGR00917 928 CNGPDPQCFRCADLSsDAQGRPSTTQFKEKLPWflnalpsadcakgghaayssavDLQGYATIIQASsfRTYHTplNTQV 1007
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 641 DFQVRRKMLNRWRATADQFAPLNVSIFDDYAPFVDTLETILPATISTSVCTLLCMMVVC-FLFMYNIFTVFVATLAITSI 719
Cdd:TIGR00917 1008 DFINAMRAAQEFAAKVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVClFLLQLNALSVVNLIMSVGMA 1087
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 720 CIGVFGFLSMWGIDLDPISMACTIMSIGFSVDFPAHITfHYFREGLHDPQSTPAKRVARSLAAIGFPLLQcgISTILFVL 799
Cdd:TIGR00917 1088 VVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHIN-AQFSTGKHFSRNHRAKEALGGMGSSVFSGIT--LTKLVGVV 1164
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 187035796 800 CLLFVPTYMGEVFVKTMIL-VVTLGLIHGLFIVPAFLCAF 838
Cdd:TIGR00917 1165 VLGFSRSEIFVVYYFRMYLaLVLLGFLHGLVFLPVLLSVL 1204
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
293-427 |
3.99e-24 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 99.19 E-value: 3.99e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 293 KVSEAVLGCVCPLLATSSALGTLFWCGFRFGTI-LCVTPFLILAIGVDDAYLQIHACMRLtaeDSLMTKREKIARMLVEV 371
Cdd:pfam12349 5 KFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIiSEVIPFLVLAIGVDNIFLLVKAVVRT---PRSLDVSERIAEALGEV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 187035796 372 GPSIAITSMTNLLAFLVGIYTPTPEISLFCAGNAVAIGFDFIYQITMYTAILSICE 427
Cdd:pfam12349 82 GPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDI 137
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
213-838 |
8.39e-18 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 88.79 E-value: 8.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 213 NWKKEDAAE----YERMISQYFH--FKYNSSHVTpLAMSLTyTGDEVVRtgltifPFIGVGFAIMTTFSVITIYYSSSRL 286
Cdd:TIGR00918 346 GWNEEKAAAvleaWQRNFSEEVQqsLPKNSSQKI-LVFSST-TLDDILK------KFSDVSAIRIVSGYLLMLAYACLTM 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 287 DQWTIHKVSEAV--LGCVCPLLATSSALGTLFWCGFRFGTILC-VTPFLILAIGVDDAYLQIHAcmrLTAEDSLMTKREK 363
Cdd:TIGR00918 418 LRWDCAKSQGSVglAGVLLVALSVAAGLGLCALLGISFNAATTqVLPFLALGVGVDDVFLLAHA---FSETGQNIPFEER 494
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 364 IARMLVEVGPSIAITSMTNLLAFLVGIYTPTPEISLFCAGNAVAIGFDFIYQITMYTAILSicenLEMRKNATKRKDSDL 443
Cdd:TIGR00918 495 TGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILS----LDLRRREDRRLDIFC 570
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 444 SF--------------------------KNEQFTVMLDSYCDWVANAY-------------------------------- 465
Cdd:TIGR00918 571 CFfspcsarviqiepqayadgsappvysSHMQSTVQLRTEYDPGTQHYyttneprshlsvqpsdplscqspdiagstrdl 650
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 466 -------------------------------------THLLVLFCFIVYIFVSIRGALNINIILSPDKLVIGDSPllQVN 508
Cdd:TIGR00918 651 lsqfedskaaclslpcarwtlatfaekhyapfllqswAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTN--EHD 728
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 509 FLRDQFVLPNYTTVNIfvnnpgnlTVQSNLDYMNS------LMESFESYPECL-------GKKFSHYFvRD--------- 566
Cdd:TIGR00918 729 FLDAQFRYFSFYNMYA--------VTQGNFDYPTQqqllydLHQSFSSVKYVLkedngqlPRMWLHYF-RDwlqglqkaf 799
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 567 ----------YESFRESSL-----------------EELEMMEDEQGESNRTSLEP-------FSKAAMSDFLAW----- 607
Cdd:TIGR00918 800 dedwrdgritKENYRNGSDdavlaykllvqtghrdkPVDKEQLTTQRLVNADGIINpnafyiyLSAWVSNDPVAYaasqa 879
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 608 ------PEFQHwngfVKFDKNGMLSRF-------WATVSYHGEGLGDFQVRRKMLNRWRATADQFAPLNVSIFDDYAPFV 674
Cdd:TIGR00918 880 niyphpPEWLH----DKNDYDPENLRIpaaepleYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSYPSGYPFL 955
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 675 -----DTLETILPATIStsvCTLLCMMVVCFLFMYNIFTVFVATLAITSICIGVFGFLSMWGIDLDPISMACTIMSIGFS 749
Cdd:TIGR00918 956 fweqyMGLRHWLLLSIS---VVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIG 1032
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 750 VDFPAHITFhyfreGLHDPQSTPAKRVARSLAAIGFPLLQCGISTILFVLCLL-----FVPTYmgevFVKTMILVVTLGL 824
Cdd:TIGR00918 1033 VEFTVHIAL-----GFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAgsefdFIVRY----FFAVLAVLTCLGV 1103
|
810
....*....|....
gi 187035796 825 IHGLFIVPAFLCAF 838
Cdd:TIGR00918 1104 LNGLVLLPVLLSMF 1117
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
16-433 |
1.20e-09 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 62.18 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 16 RLLNRFFRQCGLFVADNDKTVLIVTLLLTAFCSSKILFTPQEDDIkTGYTPDGARSLDEIEVFSDFFASTgDPIAVFLfa 95
Cdd:COG1033 386 PELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDF-EDYLPEDSPIRQDLDFIEENFGGS-DPLEVVV-- 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 96 TAKDNSSMGEYNAMKEVVEILDFVGEN-LTHKGESFYTMCTDFCQINEPVRQYYNGLAMKQQNLsdvgsrFQLTFPMMQV 174
Cdd:COG1033 462 DTGEPDGLKDPEVLKEIDRLQDYLESLpEVGKVLSLADLVKELNQALNEGDPKYYALPESRELL------AQLLLLLSSP 535
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 175 LGKELDlspNFFgvrtNEDGEveyVKIIMLQIrANIPKNWKKEDAAEYERMISQYFHFKYNSSHVTPLAMSLTYTGDEVV 254
Cdd:COG1033 536 PGDDLS---RFV----DEDYS---AARVTVRL-KDLDSEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVI 604
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 255 RTGLTIFpfigvGFAIMTTFSVITIYYSSSRLdqwtihkvseAVLGCVCPLLATSSALGTLFWCGFRFGTI-LCVTPfLI 333
Cdd:COG1033 605 ESQIRSL-----LLALLLIFLLLLLAFRSLRL----------GLISLIPNLLPILLTFGLMGLLGIPLNIAtAVVAS-IA 668
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 334 LAIGVDDAylqIHACMRLTAE-DSLMTKREKIARMLVEVGPSIAITSMTNLLAFLVGIYTPTPEISLFCAGNAVAIGFDF 412
Cdd:COG1033 669 LGIGVDYT---IHFLSRYREErRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVAL 745
|
410 420
....*....|....*....|.
gi 187035796 413 IYQITMYTAILSICENLEMRK 433
Cdd:COG1033 746 LAALLLLPALLLLLDPRIAKK 766
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
701-839 |
6.34e-08 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 56.54 E-value: 6.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 701 LFMYNIFTVFVATLAITSicigvfgflsmwgidLDPISMACTIMSIGFSVDFPAHITFHYFREGLHDPQSTPAkrVARSL 780
Cdd:TIGR03480 303 LIVGLILTAAFATLAVGH---------------LNLISVAFAVLFIGLGVDFAIQFSLRYREERFRGGNHREA--LSVAA 365
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 781 AAIGFPLLQCGISTILFVLCllFVPT-YMGevfvktmilVVTLGLIHGLFIVPAFLCAFT 839
Cdd:TIGR03480 366 RRMGAALLLAALATAAGFFA--FLPTdYKG---------VSELGIIAGTGMFIALFVTLT 414
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
669-837 |
2.33e-07 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 54.61 E-value: 2.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 669 DYAPFVDTLETIlPATISTSVCTLL----CMMVVCFLFMYNIFTVFVATLAITSICIGVFGFLSMWGIDLDPISMACTIM 744
Cdd:pfam00873 315 EIVVVYDTTPFI-RASIEEVVKTLLeaivLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVL 393
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 745 SIGFSVDfPAHITFHYFREGLHDPQSTPAKRVARSLAAIGFPLLqcgisTILFVLCLLFVPT-YMGEV-------FVKTM 816
Cdd:pfam00873 394 AIGLVVD-DAIVVVENIERVLEENGLKPLEAAYKSMGEIGGALV-----AIALVLSAVFLPIlFLGGLtgrifrqFAITI 467
|
170 180
....*....|....*....|.
gi 187035796 817 ILVVTLGLIHGLFIVPAfLCA 837
Cdd:pfam00873 468 VLAILLSVLVALTLTPA-LCA 487
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
662-837 |
1.97e-06 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 51.64 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 662 LNVSIFDDYAPFV-----DTLETILPATIstsvctlLCMMVVcFLFMYNIFTVFVATLAI-TSIcIGVFGFLSMWGIDLD 735
Cdd:COG0841 314 VELTIVYDQSEFIrasieEVVKTLLEAIL-------LVVLVV-FLFLRSWRATLIPAVAIpVSL-IGTFAVMYLLGFSLN 384
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 736 PISMACTIMSIGFSVDFpA-----HItFHYFREGLhdpqsTPAKRVARSLAAIGFPLlqcgISTILfVLCLLFVPTY--- 807
Cdd:COG0841 385 ILTLFALVLAIGIVVDD-AivvveNI-ERHMEEGL-----SPLEAAIKGAREVAGAV----IASTL-TLVAVFLPLAfmg 452
|
170 180 190
....*....|....*....|....*....|....*
gi 187035796 808 --MGEVFV---KTMILVVTLGLIHGLFIVPAfLCA 837
Cdd:COG0841 453 giTGQLFRqfaLTVAIALLISLFVALTLTPA-LCA 486
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
644-837 |
7.37e-06 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 49.73 E-value: 7.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 644 VRRKMlnrwrATADQFAP--LNVSIFDDYAPFVDtletilpATISTSVCTLLCMMVVCFLFMY----NIFTVFVATLAIT 717
Cdd:TIGR00915 306 VKAEL-----AVLEPFFPqgMKYVYPYDTTPFVE-------ASIEEVVHTLIEAIVLVFLVMYlflqNFRATLIPTIAVP 373
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 718 SICIGVFGFLSMWGIDLDPISMACTIMSIGFSVDFPAHITFHYFR----EGLhDPQSTPAKRVARSLAA-IGFPLlqcgi 792
Cdd:TIGR00915 374 VVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERvmaeEGL-PPKEATRKSMGQIQGAlVGIAM----- 447
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 187035796 793 stilfVLCLLFVPTYM-----GEV---FVKTMILVVTLGLIHGLFIVPAfLCA 837
Cdd:TIGR00915 448 -----VLSAVFVPMAFfggstGAIyrqFSITIVSAMALSVLVALILTPA-LCA 494
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
669-837 |
1.39e-05 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 49.13 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 669 DYAPFVDTletilpaTISTSVCTLLCMMVVCFLFMYNIFTVFVATL----AITSICIGVFGFLSMWGIDLDPISMACTIM 744
Cdd:PRK15127 328 DTTPFVKI-------SIHEVVKTLVEAIILVFLVMYLFLQNFRATLiptiAVPVVLLGTFAVLAAFGFSINTLTMFGMVL 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 745 SIGFSVDFPAHITFHYFR----EGLhdpqsTPAKRVARSLAAIgfpllQCGISTILFVLCLLFVP-TYMG-------EVF 812
Cdd:PRK15127 401 AIGLLVDDAIVVVENVERvmaeEGL-----PPKEATRKSMGQI-----QGALVGIAMVLSAVFVPmAFFGgstgaiyRQF 470
|
170 180
....*....|....*....|....*
gi 187035796 813 VKTMILVVTLGLIHGLFIVPAfLCA 837
Cdd:PRK15127 471 SITIVSAMALSVLVALILTPA-LCA 494
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
653-837 |
2.61e-05 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 48.29 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 653 RATADQFAP-----LNVSIFDDYAPFV-----DTLETILPAtistsvctLLCMMVVCFLFMYNIFTVFVATLAITSICIG 722
Cdd:PRK10555 307 LNRLDELAQyfphgLEYKVAYETTSFVkasieDVVKTLLEA--------IALVFLVMYLFLQNFRATLIPTIAVPVVLMG 378
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 723 VFGFLSMWGIDLDPISMACTIMSIGFSVDFPAHITFHYFR----EGLhdpqsTPAKRVARSLAAIgfpllQCGISTILFV 798
Cdd:PRK10555 379 TFSVLYAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERimseEGL-----TPREATRKSMGQI-----QGALVGIAMV 448
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 187035796 799 LCLLFVPTYM-----GEVF-------VKTMILVVTLGLIhglfIVPAfLCA 837
Cdd:PRK10555 449 LSAVFVPMAFfggttGAIYrqfsitiVSAMVLSVLVAMI----LTPA-LCA 494
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
684-835 |
4.15e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 47.14 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 684 TISTSVCTLLCMMVVCFLFMyNIFTVFVATLAITSICIGVFGFLSMWGIDLDPISMACTIMSIGFSVDFPAHITFHYFRE 763
Cdd:TIGR00921 570 RRMTIAGAILVLMILLAVFR-NPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEE 648
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187035796 764 glhDPQSTPAKRVARSLAAIGFPLLQCGISTILFVLCLLFVPTYMGEVFVKTMILVVTLGLIHGLFIVPAFL 835
Cdd:TIGR00921 649 ---RKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
223-423 |
2.93e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 41.36 E-value: 2.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 223 ERMIsQYFHFkynsshvtPLAMSLTYTGDEV--------VRTGLTIFPFIGVGFAIMttfsVITIYYSSSRldqwtihkv 294
Cdd:TIGR00921 535 LRDV-QHEHP--------PPGVKVGVTGLPVafaemhelVNEGMRRMTIAGAILVLM----ILLAVFRNPI--------- 592
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 295 sEAVLGCVCPLLATSSALGTLFWCGFRFGTILCVTPFLILAIGVDdayLQIHACMRLTAEDSLMTKREKIARMLVEVGPS 374
Cdd:TIGR00921 593 -KAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMD---YSIHLAERYFEERKEHGPKEAITHTMERTGPG 668
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 187035796 375 IAITSMTNLLAFLVGIYTPTPEISLFCAGNAVAIGFDFIYQITMYTAIL 423
Cdd:TIGR00921 669 ILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
651-751 |
3.36e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 41.38 E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 651 RWRATADQFA---PLNVS--IFDDYAPFVDTletilpaTISTSVCTLLCMMV----VCFLFMYNIFTVFVATLAITSICI 721
Cdd:PRK09577 304 RVRATMDELSryfPPGVKyqIPYETSSFVRV-------SMNKVVTTLIEAGVlvflVMFLFMQNFRATLIPTLVVPVALL 376
|
90 100 110
....*....|....*....|....*....|
gi 187035796 722 GVFGFLSMWGIDLDPISMACTIMSIGFSVD 751
Cdd:PRK09577 377 GTFGVMLAAGFSINVLTMFGMVLAIGILVD 406
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
662-813 |
5.39e-03 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 40.38 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 662 LNVSIFDDYAPFVdtlETILPATISTSVCTLLCMMVVCFLFMYNIFTVFVATLAITSICIGVFGFLSMWGIDLDPISMAC 741
Cdd:NF033617 313 IKVNVLYDRTRFI---RASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMA 389
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187035796 742 TIMSIGFSVDfPAHIT----FHYFREGlhDPQSTPAKRVARSlaaIGFPLLQCGISTILFVLCLLFVPTYMGEVFV 813
Cdd:NF033617 390 LVLAIGLVVD-DAIVVveniHRHIEEG--ESPLEAALKGARE---IGFTVIAMTLTLVAVYLPILFMGGLTGRLFR 459
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
695-835 |
9.84e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 39.44 E-value: 9.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187035796 695 MMVVCFLFMYNIFTVFVATLAITSICIGVFGFLSMWGIDLDPISMACTIMSIGFSVDFPAHITFHYFREglHDPQSTPAK 774
Cdd:TIGR00921 206 VVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEE--RDIGRAKGE 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187035796 775 RVARSLAAIGFPLLQCGISTILFVLCLLFVPTYMGEVFVKTMILVVTLGLIHGLFIVPAFL 835
Cdd:TIGR00921 284 AIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344
|
|
| |
