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Conserved domains on  [gi|147808145|emb|CAN75263|]
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hypothetical protein VITISV_005771 [Vitis vinifera]

Protein Classification

ATP-binding protein; NACHT and WD repeat domain-containing protein; WD40 and Coatomer_WDAD domain-containing protein; WD40 and RING_Ubox domain-containing protein; WD40 repeat domain-containing protein; protein kinase family protein( domain architecture ID 13237092)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to Saccharomyces cerevisiae checkpoint protein RAD24 and Arabidopsis thaliana disease resistance protein RPS5; NACHT and WD repeat domain-containing protein; WD40 and Coatomer_WDAD domain-containing protein; WD40 and RING_Ubox domain-containing protein; WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; protein kinase family protein containing WD40 repeat(s), may catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine and/or tyrosine residues on protein substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BCAS3 pfam12490
Breast carcinoma amplified sequence 3; This domain family is found in eukaryotes, and is ...
520-753 2.47e-108

Breast carcinoma amplified sequence 3; This domain family is found in eukaryotes, and is typically between 229 and 245 amino acids in length. The proteins in this family have been shown to be proto-oncogenes implicated in the development of breast cancer.


:

Pssm-ID: 463605  Cd Length: 234  Bit Score: 333.13  E-value: 2.47e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145  520 GPPVTLSVVSRIRSGNNGWRGTVTGAAAAAaaaTGRMSSLSGAIASSFHNCKAND-LFSNSSSLKEKYHLLVFSPSGCVI 598
Cdd:pfam12490   1 PPPVTLSVVSRIKNGNSGWLNTVSGAAAAA---TGKVSSPSGAIASVFHNCKGWSyGSVNSSALKPLEHLLVFSPSGHVI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145  599 QYALRISTGIDSTTVVSGLSTGYESTPDGDGRLVVEAVQKWNVCQKQHRRERED----NTDIYGENGNTDSSKIfpegik 674
Cdd:pfam12490  78 QYALRPSSGGESGDSSRGGGISYESMQETELRVVVEPIQWWDVCRRSNWPEREDplssNSDIYGDAGSSEDSKV------ 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145  675 KENAFHPETRSGVSKSKISPEERHHLYISEAELQMHQAQNPLWAKPEIYFQTMMVDGLEE----NVLGGEIEVERFPTRM 750
Cdd:pfam12490 152 KSNSIVPSNNGVDGKESLKSEERHHLYLSNAELQMHSGHTPLWQKSKISFQVMVLPTAEEdnsgNSSGGEIEIEKIPTRE 231

                  ...
gi 147808145  751 IEA 753
Cdd:pfam12490 232 IEA 234
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
361-467 1.52e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145 361 GMVIVRDIIAKSVITQFKAHKSPISALCFDPSGTLLVTAS------------------VQGHN--INVFRIMP-GVAGSS 419
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSrdktikvwdvetgkclttLRGHTdwVNSVAFSPdGTFVAS 152
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147808145 420 SGSDTCA-----SYAHLYRLQRGFTNAViQDISFSDDSNWIMISSSRGTSHLF 467
Cdd:cd00200  153 SSQDGTIklwdlRTGKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDGTIKLW 204
 
Name Accession Description Interval E-value
BCAS3 pfam12490
Breast carcinoma amplified sequence 3; This domain family is found in eukaryotes, and is ...
520-753 2.47e-108

Breast carcinoma amplified sequence 3; This domain family is found in eukaryotes, and is typically between 229 and 245 amino acids in length. The proteins in this family have been shown to be proto-oncogenes implicated in the development of breast cancer.


Pssm-ID: 463605  Cd Length: 234  Bit Score: 333.13  E-value: 2.47e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145  520 GPPVTLSVVSRIRSGNNGWRGTVTGAAAAAaaaTGRMSSLSGAIASSFHNCKAND-LFSNSSSLKEKYHLLVFSPSGCVI 598
Cdd:pfam12490   1 PPPVTLSVVSRIKNGNSGWLNTVSGAAAAA---TGKVSSPSGAIASVFHNCKGWSyGSVNSSALKPLEHLLVFSPSGHVI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145  599 QYALRISTGIDSTTVVSGLSTGYESTPDGDGRLVVEAVQKWNVCQKQHRRERED----NTDIYGENGNTDSSKIfpegik 674
Cdd:pfam12490  78 QYALRPSSGGESGDSSRGGGISYESMQETELRVVVEPIQWWDVCRRSNWPEREDplssNSDIYGDAGSSEDSKV------ 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145  675 KENAFHPETRSGVSKSKISPEERHHLYISEAELQMHQAQNPLWAKPEIYFQTMMVDGLEE----NVLGGEIEVERFPTRM 750
Cdd:pfam12490 152 KSNSIVPSNNGVDGKESLKSEERHHLYLSNAELQMHSGHTPLWQKSKISFQVMVLPTAEEdnsgNSSGGEIEIEKIPTRE 231

                  ...
gi 147808145  751 IEA 753
Cdd:pfam12490 232 IEA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
361-467 1.52e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145 361 GMVIVRDIIAKSVITQFKAHKSPISALCFDPSGTLLVTAS------------------VQGHN--INVFRIMP-GVAGSS 419
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSrdktikvwdvetgkclttLRGHTdwVNSVAFSPdGTFVAS 152
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147808145 420 SGSDTCA-----SYAHLYRLQRGFTNAViQDISFSDDSNWIMISSSRGTSHLF 467
Cdd:cd00200  153 SSQDGTIklwdlRTGKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
371-404 1.65e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 147808145   371 KSVITQFKAHKSPISALCFDPSGTLLVTASVQGH 404
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGT 35
WD40 COG2319
WD40 repeat [General function prediction only];
361-467 5.55e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 5.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145 361 GMVIVRDIIAKSVITQFKAHKSPISALCFDPSGTLLVTAS------------------VQGHNINVFRI--MPG----VA 416
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSadgtvrlwdlatgkllrtLTGHSGSVRSVafSPDgrllAS 263
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147808145 417 GSSSGSdtcasyAHLYRLQRG-------FTNAVIQDISFSDDSNWIMISSSRGTSHLF 467
Cdd:COG2319  264 GSADGT------VRLWDLATGellrtltGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
 
Name Accession Description Interval E-value
BCAS3 pfam12490
Breast carcinoma amplified sequence 3; This domain family is found in eukaryotes, and is ...
520-753 2.47e-108

Breast carcinoma amplified sequence 3; This domain family is found in eukaryotes, and is typically between 229 and 245 amino acids in length. The proteins in this family have been shown to be proto-oncogenes implicated in the development of breast cancer.


Pssm-ID: 463605  Cd Length: 234  Bit Score: 333.13  E-value: 2.47e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145  520 GPPVTLSVVSRIRSGNNGWRGTVTGAAAAAaaaTGRMSSLSGAIASSFHNCKAND-LFSNSSSLKEKYHLLVFSPSGCVI 598
Cdd:pfam12490   1 PPPVTLSVVSRIKNGNSGWLNTVSGAAAAA---TGKVSSPSGAIASVFHNCKGWSyGSVNSSALKPLEHLLVFSPSGHVI 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145  599 QYALRISTGIDSTTVVSGLSTGYESTPDGDGRLVVEAVQKWNVCQKQHRRERED----NTDIYGENGNTDSSKIfpegik 674
Cdd:pfam12490  78 QYALRPSSGGESGDSSRGGGISYESMQETELRVVVEPIQWWDVCRRSNWPEREDplssNSDIYGDAGSSEDSKV------ 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145  675 KENAFHPETRSGVSKSKISPEERHHLYISEAELQMHQAQNPLWAKPEIYFQTMMVDGLEE----NVLGGEIEVERFPTRM 750
Cdd:pfam12490 152 KSNSIVPSNNGVDGKESLKSEERHHLYLSNAELQMHSGHTPLWQKSKISFQVMVLPTAEEdnsgNSSGGEIEIEKIPTRE 231

                  ...
gi 147808145  751 IEA 753
Cdd:pfam12490 232 IEA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
361-467 1.52e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145 361 GMVIVRDIIAKSVITQFKAHKSPISALCFDPSGTLLVTAS------------------VQGHN--INVFRIMP-GVAGSS 419
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSrdktikvwdvetgkclttLRGHTdwVNSVAFSPdGTFVAS 152
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147808145 420 SGSDTCA-----SYAHLYRLQRGFTNAViQDISFSDDSNWIMISSSRGTSHLF 467
Cdd:cd00200  153 SSQDGTIklwdlRTGKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
371-404 1.65e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.65e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 147808145   371 KSVITQFKAHKSPISALCFDPSGTLLVTASVQGH 404
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGT 35
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
361-463 5.36e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 5.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145 361 GMVIVRDIIAKSVITQFKAHKSPISALCFDPSGTLLVTASVQGHnINVFRIMPGvagsssgsdtcasyaHLYRLQRGFTN 440
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTG---------------KCLGTLRGHEN 220
                         90       100
                 ....*....|....*....|...
gi 147808145 441 AVIQdISFSDDSNWIMISSSRGT 463
Cdd:cd00200  221 GVNS-VAFSPDGYLLASGSEDGT 242
WD40 COG2319
WD40 repeat [General function prediction only];
361-467 5.55e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 5.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145 361 GMVIVRDIIAKSVITQFKAHKSPISALCFDPSGTLLVTAS------------------VQGHNINVFRI--MPG----VA 416
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSadgtvrlwdlatgkllrtLTGHSGSVRSVafSPDgrllAS 263
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147808145 417 GSSSGSdtcasyAHLYRLQRG-------FTNAVIQDISFSDDSNWIMISSSRGTSHLF 467
Cdd:COG2319  264 GSADGT------VRLWDLATGellrtltGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
374-461 8.04e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 8.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145 374 ITQFKAHKSPISALCFDPSGTLLVTAS------------------VQGHNINVFRIMPGVAGS---SSGSDTCASyahLY 432
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSgdgtikvwdletgellrtLKGHTGPVRDVAASADGTylaSGSSDKTIR---LW 78
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 147808145 433 RLQ--------RGFTNAVIqDISFSDDSNWImISSSR 461
Cdd:cd00200   79 DLEtgecvrtlTGHTSYVS-SVAFSPDGRIL-SSSSR 113
WD40 COG2319
WD40 repeat [General function prediction only];
361-467 9.32e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 9.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145 361 GMVIVRDIIAKSVITQFKAHKSPISALCFDPSGTLLVTASvQGHNINVFRIMPGvagsssgsdtcasyAHLYRLqRGFTN 440
Cdd:COG2319  142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGS-DDGTVRLWDLATG--------------KLLRTL-TGHTG 205
                         90       100
                 ....*....|....*....|....*..
gi 147808145 441 AViQDISFSDDSNWIMISSSRGTSHLF 467
Cdd:COG2319  206 AV-RSVAFSPDGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
361-463 9.57e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 9.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147808145 361 GMVIVRDIIAKSVITQFKAHKSPISALCFDPSGTLLVTASvQGHNINVFRImpgvagsssgsdtcASYAHLYRLQrGFTN 440
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS-DDGTVRLWDL--------------ATGKLLRTLT-GHTG 331
                         90       100
                 ....*....|....*....|...
gi 147808145 441 AViQDISFSDDSNWIMISSSRGT 463
Cdd:COG2319  332 AV-RSVAFSPDGKTLASGSDDGT 353
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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