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Conserved domains on  [gi|124399033|emb|CAK64528|]
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unnamed protein product (macronuclear) [Paramecium tetraurelia]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
1-324 0e+00

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19143:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 319  Bit Score: 543.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVIS 80
Cdd:cd19143    1 MEYRRLGRSGLKVSALSFGSWVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGWPRSDYVVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  81 TKIYGGDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQ 160
Cdd:cd19143   81 TKIFWGGGGPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 IHQAIGICDRLSLHKPVVEQPQYNMMVRDRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDNIYVK 239
Cdd:cd19143  161 IEEAHEIADRLGLIPPVMEQPQYNLFHRERVEVEYAPLYEKyGLGTTTWSPLASGLLTGKYNNGIPEGSRLALPGYEWLK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 240 HFYQqilgdpEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEVEQ 319
Cdd:cd19143  241 DRKE------ELGQEKIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEENLKALEVLPKLTPEVME 314

                 ....*
gi 124399033 320 KIESI 324
Cdd:cd19143  315 KIEAI 319
 
Name Accession Description Interval E-value
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
1-324 0e+00

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 543.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVIS 80
Cdd:cd19143    1 MEYRRLGRSGLKVSALSFGSWVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGWPRSDYVVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  81 TKIYGGDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQ 160
Cdd:cd19143   81 TKIFWGGGGPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 IHQAIGICDRLSLHKPVVEQPQYNMMVRDRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDNIYVK 239
Cdd:cd19143  161 IEEAHEIADRLGLIPPVMEQPQYNLFHRERVEVEYAPLYEKyGLGTTTWSPLASGLLTGKYNNGIPEGSRLALPGYEWLK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 240 HFYQqilgdpEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEVEQ 319
Cdd:cd19143  241 DRKE------ELGQEKIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEENLKALEVLPKLTPEVME 314

                 ....*
gi 124399033 320 KIESI 324
Cdd:cd19143  315 KIEAI 319
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
1-329 3.01e-105

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 311.34  E-value: 3.01e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNT--KIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvqRQDIV 78
Cdd:COG0667    1 MEYRRLGRSGLKVSRLGLGTMTFGGPWGGVDEAEaiAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRP--RDDVV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  79 ISTKIyGGDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTA 158
Cdd:COG0667   79 IATKV-GRRMGPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 159 QQIHQAIGICDrlSLHKPVVEQPQYNMMVRdRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDD--ILADGRFNNSdn 235
Cdd:COG0667  158 EQLRRALAIAE--GLPPIVAVQNEYSLLDR-SAEEELLPAARElGVGVLAYSPLAGGLLTGKYRRGatFPEGDRAATN-- 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 236 iyvkhfyqqiLGDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklITK 315
Cdd:COG0667  233 ----------FVQGYLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLE--LSA 300
                        330
                 ....*....|....
gi 124399033 316 EVEQKIESILSNKP 329
Cdd:COG0667  301 EDLAALDAALAAVP 314
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
16-325 3.69e-63

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 202.93  E-value: 3.69e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   16 ISYGNWVNSDDKDTQDRNT--KIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVISTKIYGGDGndfPN 93
Cdd:pfam00248   1 IGLGTWQLGGGWGPISKEEalEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDKVVIATKVPDGDG---PW 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   94 SKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAigicDRLSL 173
Cdd:pfam00248  78 PSGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKA----LTKGK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  174 HKPVVEQPQYNmMVRDRFEWE-YESVFASGYGSTIWSPLYQGLLTGKYNDDIladgrfnnsDNIYVKHFYQQILGDPEKR 252
Cdd:pfam00248 154 IPIVAVQVEYN-LLRRRQEEElLEYCKKNGIPLIAYSPLGGGLLTGKYTRDP---------DKGPGERRRLLKKGTPLNL 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124399033  253 TKIQNqlkqLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklITKEVEQKIESIL 325
Cdd:pfam00248 224 EALEA----LEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFP--LSDEEVARIDELL 290
PRK09912 PRK09912
L-glyceraldehyde 3-phosphate reductase; Provisional
1-319 1.92e-54

L-glyceraldehyde 3-phosphate reductase; Provisional


Pssm-ID: 182140 [Multi-domain]  Cd Length: 346  Bit Score: 182.11  E-value: 1.92e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGD--GKAEIHLGHALKT-LNVQRQDI 77
Cdd:PRK09912  13 MQYRYCGKSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPppGSAEENFGRLLREdFAAYRDEL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  78 VISTKIyGGDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWT 157
Cdd:PRK09912  93 IISTKA-GYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 158 AQQIHQAIGICDRLSLhkP-VVEQPQYNMMVRdrfeWE-----YESVFASGYGSTIWSPLYQGLLTGKYNDDILADGRFN 231
Cdd:PRK09912 172 PERTQKMVELLREWKI--PlLIHQPSYNLLNR----WVdksglLDTLQNNGVGCIAFTPLAQGLLTGKYLNGIPQDSRMH 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 232 NSDNiYVKHFYQQILGDPEkrtkiQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVK 311
Cdd:PRK09912 246 REGN-KVRGLTPKMLTEAN-----LNSLRLLNEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQALNNLT 319

                 ....*...
gi 124399033 312 LITKEVEQ 319
Cdd:PRK09912 320 FSTEELAQ 327
 
Name Accession Description Interval E-value
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
1-324 0e+00

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 543.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVIS 80
Cdd:cd19143    1 MEYRRLGRSGLKVSALSFGSWVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGWPRSDYVVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  81 TKIYGGDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQ 160
Cdd:cd19143   81 TKIFWGGGGPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 IHQAIGICDRLSLHKPVVEQPQYNMMVRDRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDNIYVK 239
Cdd:cd19143  161 IEEAHEIADRLGLIPPVMEQPQYNLFHRERVEVEYAPLYEKyGLGTTTWSPLASGLLTGKYNNGIPEGSRLALPGYEWLK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 240 HFYQqilgdpEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEVEQ 319
Cdd:cd19143  241 DRKE------ELGQEKIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEENLKALEVLPKLTPEVME 314

                 ....*
gi 124399033 320 KIESI 324
Cdd:cd19143  315 KIEAI 319
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
10-307 1.30e-121

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 352.28  E-value: 1.30e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvqRQDIVISTKIYGGDGn 89
Cdd:cd19074    1 GLKVSELSLGTWLTFGGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGWP--RESYVISTKVFWPTG- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  90 DFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICD 169
Cdd:cd19074   78 PGPNDRGLSRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDLAR 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 170 RLSLHKPVVEQPQYNMMVRDRFEWEYESVFASGYGSTIWSPLYQGLLTGKYNDDIL--ADGRFNNSDNiyvKHFYQQILG 247
Cdd:cd19074  158 QFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTGKYRDGIPppSRSRATDEDN---RDKKRRLLT 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 248 DpekrtKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSV 307
Cdd:cd19074  235 D-----ENLEKVKKLKPIADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKAS 289
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
1-329 3.01e-105

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 311.34  E-value: 3.01e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNT--KIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvqRQDIV 78
Cdd:COG0667    1 MEYRRLGRSGLKVSRLGLGTMTFGGPWGGVDEAEaiAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRP--RDDVV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  79 ISTKIyGGDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTA 158
Cdd:COG0667   79 IATKV-GRRMGPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 159 QQIHQAIGICDrlSLHKPVVEQPQYNMMVRdRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDD--ILADGRFNNSdn 235
Cdd:COG0667  158 EQLRRALAIAE--GLPPIVAVQNEYSLLDR-SAEEELLPAARElGVGVLAYSPLAGGLLTGKYRRGatFPEGDRAATN-- 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 236 iyvkhfyqqiLGDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklITK 315
Cdd:COG0667  233 ----------FVQGYLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLE--LSA 300
                        330
                 ....*....|....
gi 124399033 316 EVEQKIESILSNKP 329
Cdd:COG0667  301 EDLAALDAALAAVP 314
Aldo_ket_red_shaker cd19141
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ...
3-317 5.96e-91

Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381367 [Multi-domain]  Cd Length: 310  Bit Score: 274.71  E-value: 5.96e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   3 YRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVISTK 82
Cdd:cd19141    2 YRNLGKSGLRVSCLGLGTWVTFGSQISDEVAEELVTLAYENGINLFDTAEVYAAGKAEIVLGKILKKKGWRRSSYVITTK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  83 IY-GGDGNdfpNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQI 161
Cdd:cd19141   82 IFwGGKAE---TERGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWSAMEI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 162 HQAIGICDRLSLHKPVVEQPQYNMMVRDRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDNIYVKh 240
Cdd:cd19141  159 MEAYSVARQFNLIPPIVEQAEYHLFQREKVEMQLPELFHKiGVGAMTWSPLACGILSGKYDDGVPEYSRASLKGYQWLK- 237
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124399033 241 fyQQILGDPEKRTkiQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEV 317
Cdd:cd19141  238 --EKILSEEGRRQ--QAKLKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQLYENLQAIQVLPKLTPNI 310
AKR_KCAB3B_AKR6A9-like cd19160
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ...
1-329 1.19e-88

voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.


Pssm-ID: 381386 [Multi-domain]  Cd Length: 325  Bit Score: 269.55  E-value: 1.19e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVIS 80
Cdd:cd19160    3 MKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  81 TKIYGGDGNDfpNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQ 160
Cdd:cd19160   83 TKIYWGGQAE--TERGLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAME 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 IHQAIGICDRLSLHKPVVEQPQYNMMVRDRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDNIYVK 239
Cdd:cd19160  161 IMEAYSVARQFNLIPPVCEQAEYHLFQREKVEMQLPELYHKiGVGSVTWSPLACGLITGKYDGRVPDTCRAAVKGYQWLK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 240 HFYQQilgdpEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEVEQ 319
Cdd:cd19160  241 EKVQS-----EEGKKQQAKVKELHPIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIENLGSIQVLSQLTPQTVM 315
                        330
                 ....*....|
gi 124399033 320 KIESILSNKP 329
Cdd:cd19160  316 EIDALLGNKP 325
AKR_KCAB1B_AKR6A3-like cd19159
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ...
1-329 5.31e-88

voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.


Pssm-ID: 381385 [Multi-domain]  Cd Length: 323  Bit Score: 267.68  E-value: 5.31e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVIS 80
Cdd:cd19159    1 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  81 TKIYGGDGNDfpNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQ 160
Cdd:cd19159   81 TKLYWGGKAE--TERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAME 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 IHQAIGICDRLSLHKPVVEQPQYNMMVRDRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDNIYVK 239
Cdd:cd19159  159 IMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKiGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLK 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 240 hfyQQILGdpEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEVEQ 319
Cdd:cd19159  239 ---ERIVS--EEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVN 313
                        330
                 ....*....|
gi 124399033 320 KIESILSNKP 329
Cdd:cd19159  314 EIDNILRNKP 323
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
1-324 1.02e-84

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 258.66  E-value: 1.02e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYG--NWVNSDDKDTqdrNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTlnvQRQDIV 78
Cdd:cd19087    1 MEYRTLGRTGLKVSRLCLGtmNFGGRTDEET---SFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAG---RRDDIV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  79 ISTKIYGGDGNDfPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTA 158
Cdd:cd19087   75 LATKVFGPMGDD-PNDRGLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSNFAA 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 159 QQIHQAIGICDRLSLHKPVVEQPQYNMMVRdRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYnddilADGRFNNSDNIY 237
Cdd:cd19087  154 WQIAKAQGIAARRGLLRFVSEQPMYNLLKR-QAELEILPAARAyGLGVIPYSPLAGGLLTGKY-----GKGKRPESGRLV 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 238 VKHFYQQILGDPEKRTKIQnqlkQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklITKEV 317
Cdd:cd19087  228 ERARYQARYGLEEYRDIAE----RFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEIT--LTPEL 301

                 ....*..
gi 124399033 318 EQKIESI 324
Cdd:cd19087  302 LAEIDEL 308
AKR_KCAB2B_AKR6A1-like cd19158
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ...
1-329 2.74e-81

voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.


Pssm-ID: 381384 [Multi-domain]  Cd Length: 324  Bit Score: 250.39  E-value: 2.74e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVIS 80
Cdd:cd19158    1 QFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  81 TKIYGGDGNDfpNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQ 160
Cdd:cd19158   81 TKIFWGGKAE--TERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSME 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 IHQAIGICDRLSLHKPVVEQPQYNMMVRDRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDNIYVK 239
Cdd:cd19158  159 IMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKiGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLK 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 240 hfyQQILGDPEKRTkiQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEVEQ 319
Cdd:cd19158  239 ---DKILSEEGRRQ--QAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVH 313
                        330
                 ....*....|
gi 124399033 320 KIESILSNKP 329
Cdd:cd19158  314 EIDSILGNKP 323
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
2-309 6.15e-81

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 249.04  E-value: 6.15e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   2 EYRRLGATGLKVSAI-----SYG----NWVNSDDKDTQdrntKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTlNV 72
Cdd:cd19079    1 EYVRLGNSGLKVSRLclgcmSFGdpkwRPWVLDEEESR----PIIKRALDLGINFFDTANVYSGGASEEILGRALKE-FA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  73 QRQDIVISTKIYGgDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWG 152
Cdd:cd19079   76 PRDEVVIATKVYF-PMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 153 TSEWTAQQIHQAIGICDRLSLHKPVVEQPQYNMMVRdrfEWEYESV---FASGYGSTIWSPLYQGLLTGKYNDdilaDGR 229
Cdd:cd19079  155 ASSMYAWQFAKALHLAEKNGWTKFVSMQNHYNLLYR---EEEREMIplcEEEGIGVIPWSPLARGRLARPWGD----TTE 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 230 FNNSDNIYVKHFYqqiLGDPEKRTKIqnqLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQV 309
Cdd:cd19079  228 RRRSTTDTAKLKY---DYFTEADKEI---VDRVEEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDI 301
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
1-319 7.36e-80

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 246.76  E-value: 7.36e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYG------------NWVNSDDKDTqdrnTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALK 68
Cdd:cd19091    1 MEYRTLGRSGLKVSELALGtmtfgggggffgAWGGVDQEEA----DRLVDIALDAGINFFDTADVYSEGESEEILGKALK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  69 TLnvqRQDIVISTKIYGGDGNDfPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLA 148
Cdd:cd19091   77 GR---RDDVLIATKVRGRMGEG-PNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKV 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 149 HYWGTSEWTAQQIHQAIGICDRLSLHKPVVEQPQYNMMVRDrFEWEYESV-FASGYGSTIWSPLYQGLLTGKY-NDDILA 226
Cdd:cd19091  153 RYIGVSNFSAWQIMKALGISERRGLARFVALQAYYSLLGRD-LEHELMPLaLDQGVGLLVWSPLAGGLLSGKYrRGQPAP 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 227 DGRFNNSDNIYvkhfyqqilGDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKS 306
Cdd:cd19091  232 EGSRLRRTGFD---------FPPVDRERGYDVVDALREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGA 302
                        330
                 ....*....|...
gi 124399033 307 VQvVKLITKEVEQ 319
Cdd:cd19091  303 AG-LSLTPEEIAR 314
AKR_AKR6B1 cd19142
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...
1-329 2.22e-79

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.


Pssm-ID: 381368 [Multi-domain]  Cd Length: 325  Bit Score: 245.45  E-value: 2.22e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVIS 80
Cdd:cd19142    1 LKYRNLGKSGLRVSNVGLGTWSTFSTAISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKKKGWKRSSYIVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  81 TKIYGGDGndfPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQ 160
Cdd:cd19142   81 TKIYWSYG---SEERGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSPVE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 IHQAIGICDRLSLHKPVVEQPQYNMMVRDRFEWEYESVF-ASGYGSTIWSPLYQGLLTGKynDDILADGRFNNSDNIYVK 239
Cdd:cd19142  158 IMEAFSIARQFNCPTPICEQSEYHMFCREKMELYMPELYnKVGVGLITWSPLSLGLDPGI--SEETRRLVTKLSFKSSKY 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 240 HFYQQILGDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEVEQ 319
Cdd:cd19142  236 KVGSDGNGIHEETRRASHKLRELSLIAERLGCDLTQLLIAWSLKNENVQCVLIGASSLEQLYSQLNSLQLLPKLNSAVME 315
                        330
                 ....*....|
gi 124399033 320 KIESILSNKP 329
Cdd:cd19142  316 ELERILDNKP 325
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
3-317 3.31e-78

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 241.78  E-value: 3.31e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   3 YRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYG--DGKAEIHLGHALKT-LNVQRQDIVI 79
Cdd:cd19089    1 YRRCGRSGLHLPAISLGLWHNFGDYTSPEEARELLRTAFDLGITHFDLANNYGppPGSAEENFGRILKRdLRPYRDELVI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  80 STKI-YG-GDGndfPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWT 157
Cdd:cd19089   81 STKAgYGmWPG---PYGDGGSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGISNYP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 158 AQQIHQAIGICDRLSLhKPVVEQPQYNMMVRDRFEWEYESVFASGYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDniy 237
Cdd:cd19089  158 GAKARRAIALLRELGV-PLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKYLNGIPPDSRRAAES--- 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 238 vkhfyqQILGDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEV 317
Cdd:cd19089  234 ------KFLTEEALTPEKLEQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALKNLDFSEEEL 307
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
10-322 7.36e-71

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 222.79  E-value: 7.36e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWV-------NSDDKDTQDrntkIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLnvqRQDIVISTK 82
Cdd:cd19084    1 DLKVSRIGLGTWAiggtwwgEVDDQESIE----AIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGR---RDDVVIATK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  83 iYGGDGNDFPNSKY-LSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQI 161
Cdd:cd19084   74 -CGLRWDGGKGVTKdLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 162 HQAIgicdrlSLHKPVVEQPQYNMMVRDrfewEYESVF----ASGYGSTIWSPLYQGLLTGKYNDdilaDGRFNNSDNIY 237
Cdd:cd19084  153 EEAR------KYGPIVSLQPPYSMLERE----IEEELLpycrENGIGVLPYGPLAQGLLTGKYKK----EPTFPPDDRRS 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 238 VKHFYQqilgdPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklITKEV 317
Cdd:cd19084  219 RFPFFR-----GENFEKNLEIVDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWE--LTEEE 291

                 ....*
gi 124399033 318 EQKIE 322
Cdd:cd19084  292 LKEID 296
AKR_AKR14A2 cd19151
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ...
2-308 3.64e-69

Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).


Pssm-ID: 381377 [Multi-domain]  Cd Length: 309  Bit Score: 218.81  E-value: 3.64e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   2 EYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGD--GKAEIHLGHALKT-LNVQRQDIV 78
Cdd:cd19151    1 KYNRCGRSGLKLPAISLGLWHNFGDVDRYENSRAMLRRAFDLGITHFDLANNYGPppGSAEENFGRILKEdLKPYRDELI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  79 ISTKI--YGGDGndfPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEW 156
Cdd:cd19151   81 ISTKAgyTMWPG---PYGDWGSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 157 TAQQIHQAIGICDRLSLhKPVVEQPQYNMMVRdrfeWEYESVFA----SGYGSTIWSPLYQGLLTGKYNDDILADGR--- 229
Cdd:cd19151  158 PPEEAREAAAILKDLGT-PCLIHQPKYSMFNR----WVEEGLLDvleeEGIGCIAFSPLAQGLLTDRYLNGIPEDSRaak 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 230 ---FNNSDNIyvkhfyqqilgDPEKRTKIqnqlKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKS 306
Cdd:cd19151  233 gssFLKPEQI-----------TEEKLAKV----RRLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGA 297

                 ..
gi 124399033 307 VQ 308
Cdd:cd19151  298 LD 299
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
5-319 6.93e-68

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 215.54  E-value: 6.93e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   5 RLGATGLKVSAISYGNWV---NSDDKDTQDrntkiIQKAW-ELGINFFDTAEIYGD-------GKAEIHLGHALKTlNVQ 73
Cdd:cd19081    1 PLGRTGLSVSPLCLGTMVfgwTADEETSFA-----LLDAFvDAGGNFIDTADVYSAwvpgnagGESETIIGRWLKS-RGK 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  74 RQDIVISTKIYGGDGndfPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGT 153
Cdd:cd19081   75 RDRVVIATKVGFPMG---PNGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGA 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 154 SEWTAQQIHQAIGICDRLSLHKPVVEQPQYNMMVRDRFEWEYESV-FASGYGSTIWSPLYQGLLTGKYNDDILADGRFNN 232
Cdd:cd19081  152 SNYSAWRLQEALELSRQHGLPRYVSLQPEYNLVDRESFEGELLPLcREEGIGVIPYSPLAGGFLTGKYRSEADLPGSTRR 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 233 SDniyvkhFYQQILGDPEKRTkiqnqLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQvVKL 312
Cdd:cd19081  232 GE------AAKRYLNERGLRI-----LDALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAAAG-LRL 299

                 ....*..
gi 124399033 313 ITKEVEQ 319
Cdd:cd19081  300 TDEEVAR 306
AKR_AKR14A1 cd19150
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ...
3-318 2.01e-63

Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.


Pssm-ID: 381376 [Multi-domain]  Cd Length: 309  Bit Score: 204.22  E-value: 2.01e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   3 YRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGD--GKAEIHLGHALKT-LNVQRQDIVI 79
Cdd:cd19150    2 YRRCGKSGLKLPALSLGLWHNFGDDTPLETQRAILRTAFDLGITHFDLANNYGPppGSAEENFGRILREdFAGYRDELII 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  80 STKIyGGDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQ 159
Cdd:cd19150   82 STKA-GYDMWPGPYGEWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSYSPE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 160 QIHQAIGICDRLSLhkP-VVEQPQYNMMVRDRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDNIY 237
Cdd:cd19150  161 RTREAAAILRELGT--PlLIHQPSYNMLNRWVEESGLLDTLQElGVGCIAFTPLAQGLLTDKYLNGIPEGSRASKERSLS 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 238 VKHFYQQILgdpekrtkiqNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKLITKEV 317
Cdd:cd19150  239 PKMLTEANL----------NSIRALNEIAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGALDNLTFSADEL 308

                 .
gi 124399033 318 E 318
Cdd:cd19150  309 A 309
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
16-325 3.69e-63

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 202.93  E-value: 3.69e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   16 ISYGNWVNSDDKDTQDRNT--KIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVISTKIYGGDGndfPN 93
Cdd:pfam00248   1 IGLGTWQLGGGWGPISKEEalEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDKVVIATKVPDGDG---PW 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   94 SKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAigicDRLSL 173
Cdd:pfam00248  78 PSGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKA----LTKGK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  174 HKPVVEQPQYNmMVRDRFEWE-YESVFASGYGSTIWSPLYQGLLTGKYNDDIladgrfnnsDNIYVKHFYQQILGDPEKR 252
Cdd:pfam00248 154 IPIVAVQVEYN-LLRRRQEEElLEYCKKNGIPLIAYSPLGGGLLTGKYTRDP---------DKGPGERRRLLKKGTPLNL 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124399033  253 TKIQNqlkqLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklITKEVEQKIESIL 325
Cdd:pfam00248 224 EALEA----LEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFP--LSDEEVARIDELL 290
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
14-305 2.12e-57

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 185.80  E-value: 2.12e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  14 SAISYGNWVNSDDKDtQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVqRQDIVISTKIyGGDGNDFPN 93
Cdd:cd06660    1 SRLGLGTMTFGGDGD-EEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGN-RDDVVIATKG-GHPPGGDPS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  94 SKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDRLSL 173
Cdd:cd06660   78 RSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKAHGL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 174 HKPVVEQPQYNMMVRDRFEWEYESVF-ASGYGSTIWSPLYQGLltgkynddiladgrfnnsdniyvkhfyqqilgdpekr 252
Cdd:cd06660  158 PGFAAVQPQYSLLDRSPMEEELLDWAeENGLPLLAYSPLARGP------------------------------------- 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124399033 253 tkiqnqlkqlgevakelgvtqAQLSLAWALKNKDVSTAITSATRPEQLEETVK 305
Cdd:cd06660  201 ---------------------AQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
13-324 6.36e-57

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 186.64  E-value: 6.36e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  13 VSAISYGNWVNSDD----KDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTlnvQRQDIVISTKIYGgdg 88
Cdd:cd19085    1 VSRLGLGCWQFGGGywwgDQDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALKG---RRDDVVIATKVSP--- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  89 ndfpnsKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGIC 168
Cdd:cd19085   75 ------DNLTPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAG 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 169 drlslhKPVVEQPQYNMMVRdrfEWEYEsVF----ASGYGSTIWSPLYQGLLTGKYNddilADGRFNNSDNIYvKHFyqq 244
Cdd:cd19085  149 ------RIDSNQLPYNLLWR---AIEYE-ILpfcrEHGIGVLAYSPLAQGLLTGKFS----SAEDFPPGDART-RLF--- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 245 ILGDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklITKEVEQKIESI 324
Cdd:cd19085  211 RHFEPGAEEETFEALEKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLE--LSPSVLERLDEI 288
PRK09912 PRK09912
L-glyceraldehyde 3-phosphate reductase; Provisional
1-319 1.92e-54

L-glyceraldehyde 3-phosphate reductase; Provisional


Pssm-ID: 182140 [Multi-domain]  Cd Length: 346  Bit Score: 182.11  E-value: 1.92e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGD--GKAEIHLGHALKT-LNVQRQDI 77
Cdd:PRK09912  13 MQYRYCGKSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPppGSAEENFGRLLREdFAAYRDEL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  78 VISTKIyGGDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWT 157
Cdd:PRK09912  93 IISTKA-GYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 158 AQQIHQAIGICDRLSLhkP-VVEQPQYNMMVRdrfeWE-----YESVFASGYGSTIWSPLYQGLLTGKYNDDILADGRFN 231
Cdd:PRK09912 172 PERTQKMVELLREWKI--PlLIHQPSYNLLNR----WVdksglLDTLQNNGVGCIAFTPLAQGLLTGKYLNGIPQDSRMH 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 232 NSDNiYVKHFYQQILGDPEkrtkiQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVK 311
Cdd:PRK09912 246 REGN-KVRGLTPKMLTEAN-----LNSLRLLNEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQALNNLT 319

                 ....*...
gi 124399033 312 LITKEVEQ 319
Cdd:PRK09912 320 FSTEELAQ 327
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
3-309 1.13e-51

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 174.00  E-value: 1.13e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   3 YRRLGATGLKVSAISYGNWV--------NSDDKDTqdrnTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLnvqR 74
Cdd:cd19149    1 YRKLGKSGIEASVIGLGTWAigggpwwgGSDDNES----IRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGR---R 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  75 QDIVISTKI----------YGGDGNDFPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIR 144
Cdd:cd19149   74 DKVVLATKCglrwdreggsFFFVRDGVTVYKNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 145 HGLAHYWGTSEWTAQQIHQAigicdrLSLHKPVVEQPQYNMMvrDRFEWEYESVFASGYGSTI--WSPLYQGLLTGKynd 222
Cdd:cd19149  154 QGKIRAIGASNVSVEQIKEY------VKAGQLDIIQEKYSML--DRGIEKELLPYCKKNNIAFqaYSPLEQGLLTGK--- 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 223 dILADGRFNNSDNIYVKHFYQqilgdPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEE 302
Cdd:cd19149  223 -ITPDREFDAGDARSGIPWFS-----PENREKVLALLEKWKPLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEE 296

                 ....*..
gi 124399033 303 TVKSVQV 309
Cdd:cd19149  297 NAKAGDI 303
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
10-325 4.16e-51

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 172.03  E-value: 4.16e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYG----NWVNSDDKDTQDrNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLnvqRQDIVISTK--- 82
Cdd:cd19078    1 GLEVSAIGLGcmgmSHGYGPPPDKEE-MIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPF---RDQVVIATKfgf 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  83 -IYGG-DGNDFPNSKYLSRKHLIEGlrnSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQ 160
Cdd:cd19078   77 kIDGGkPGPLGLDSRPEHIRKAVEG---SLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSEAGVET 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 IHQAIGICdrlslhkPVVE-QPQYNMMVRdrfewEYES-VF----ASGYGSTIWSPLYQGLLTGKYNddilADGRFNNSD 234
Cdd:cd19078  154 IRRAHAVC-------PVTAvQSEYSMMWR-----EPEKeVLptleELGIGFVPFSPLGKGFLTGKID----ENTKFDEGD 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 235 NIYVKHFYQqilgdPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklIT 314
Cdd:cd19078  218 DRASLPRFT-----PEALEANQALVDLLKEFAEEKGATPAQIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIE--LT 290
                        330
                 ....*....|.
gi 124399033 315 KEVEQKIESIL 325
Cdd:cd19078  291 PEELREIEDAL 301
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
13-324 1.19e-49

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 168.90  E-value: 1.19e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  13 VSAISYG--NWVNsddKDTQDRNTKIIQKAWELGINFFDTAEIY-------GDGKAEIHLGHALKTlNVQRQDIVISTKI 83
Cdd:cd19094    1 VSEICLGtmTWGE---QNTEAEAHEQLDYAFDEGVNFIDTAEMYpvppspeTQGRTEEIIGSWLKK-KGNRDKVVLATKV 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  84 YG-GDGNDFPNSKY--LSRKHLIEGLRNSLKRLDTPYVDIVFAH---RY-------DY--------QTPLEETCRAFDWI 142
Cdd:cd19094   77 AGpGEGITWPRGGGtrLDRENIREAVEGSLKRLGTDYIDLYQLHwpdRYtplfgggYYtepseeedSVSFEEQLEALGEL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 143 IRHGLAHYWGTSEWTAQQIHQAIGICDRLSLHKPVVEQPQYNMMVRDRFE--WE---YESVfasgyGSTIWSPLYQGLLT 217
Cdd:cd19094  157 VKAGKIRHIGLSNETPWGVMKFLELAEQLGLPRIVSIQNPYSLLNRNFEEglAEachRENV-----GLLAYSPLAGGVLT 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 218 GKYND--DILADGRFNnsdnIYvKHFYQQILGDPEKRtkiqnQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSAT 295
Cdd:cd19094  232 GKYLDgaARPEGGRLN----LF-PGYMARYRSPQALE-----AVAEYVKLARKHGLSPAQLALAWVRSRPFVTSTIIGAT 301
                        330       340
                 ....*....|....*....|....*....
gi 124399033 296 RPEQLEETVKSVQVVklITKEVEQKIESI 324
Cdd:cd19094  302 TLEQLKENIDAFDVP--LSDELLAEIDAV 328
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
4-310 2.51e-49

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 167.40  E-value: 2.51e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   4 RRLGATGLKVS-----AISYGN-WVNSDDKDTqdrNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLnvqRQDI 77
Cdd:cd19080    1 RLLGRSGLRVSplalgTMTFGTeWGWGADREE---ARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGN---RDRI 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  78 VISTK-IYGGDGNDfPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEW 156
Cdd:cd19080   75 VLATKyTMNRRPGD-PNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISDT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 157 TAQQIHQAIGICDRLSLHKPVVEQPQYNMMVRDrFEWEYESVF-ASGYGSTIWSPLYQGLLTGKYNDDILADGRFNNSDN 235
Cdd:cd19080  154 PAWVVARANTLAELRGWSPFVALQIEYSLLERT-PERELLPMArALGLGVTPWSPLGGGLLTGKYQRGEEGRAGEAKGVT 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124399033 236 IYVKHFyqqilgdPEKRTKIQnqlKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVV 310
Cdd:cd19080  233 VGFGKL-------TERNWAIV---DVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLT 297
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
2-310 2.65e-47

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 162.00  E-value: 2.65e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   2 EYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKI--IQKAWELGINFFDTAEIYGDGKAEIHLGHALKTlnvQRQDIVI 79
Cdd:cd19076    1 PTRKLGTQGLEVSALGLGCMGMSAFYGPADEEESIatLHRALELGVTFLDTADMYGPGTNEELLGKALKD---RRDEVVI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  80 STK----IYGGDGNDFPNSkylSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSE 155
Cdd:cd19076   78 ATKfgivRDPGSGFRGVDG---RPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGLSE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 156 WTAQQIHQAIGIcdrlslHKPVVEQPQYNMMVRDrFEweyESVFAS----GYGSTIWSPLYQGLLTGKY---NDDILADG 228
Cdd:cd19076  155 ASADTIRRAHAV------HPITAVQSEYSLWTRD-IE---DEVLPTcrelGIGFVAYSPLGRGFLTGAIkspEDLPEDDF 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 229 RFNNSdniyvkhFYQqilgdPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQ 308
Cdd:cd19076  225 RRNNP-------RFQ-----GENFDKNLKLVEKLEAIAAEKGCTPAQLALAWVLAQGDDIVPIPGTKRIKYLEENVGALD 292

                 ..
gi 124399033 309 VV 310
Cdd:cd19076  293 VV 294
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
4-324 2.11e-44

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 154.50  E-value: 2.11e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   4 RRLGATGLKVSAISYGN--------WVNSDDKDTQDrntkIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvqRQ 75
Cdd:cd19083    2 VKLGKSDIDVNPIGLGTnavgghnlYPNLDEEEGKD----LVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEYN--RN 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  76 DIVISTK---IYGGDGNDFPNSkylsRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWG 152
Cdd:cd19083   76 EVVIATKgahKFGGDGSVLNNS----PEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 153 TSEWTAQQIHQA--IGICDrlslhkpvVEQPQYNMMVRDRFEWEYESVFASGYGSTIWSPLYQGLLTGKYNDDI-LADGR 229
Cdd:cd19083  152 VSNFSLEQLKEAnkDGYVD--------VLQGEYNLLQREAEEDILPYCVENNISFIPYFPLASGLLAGKYTKDTkFPDND 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 230 FNNSDNIYVKHFYQQILGDPEKrtkiqnqlkqLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQV 309
Cdd:cd19083  224 LRNDKPLFKGERFSENLDKVDK----------LKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALDV 293
                        330
                 ....*....|....*
gi 124399033 310 VklITKEVEQKIESI 324
Cdd:cd19083  294 T--LTEEEIAFIDAL 306
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
42-313 1.39e-42

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 149.63  E-value: 1.39e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  42 ELGINFFDTAEIYGDGKAEIHLGHALktlnVQRQDIVISTKIYGGDGNDfpnskyLSRKHLIEGLRNSLKRLDTPYVDIV 121
Cdd:cd19075   31 ERGHTEIDTARVYPDGTSEELLGELG----LGERGFKIDTKANPGVGGG------LSPENVRKQLETSLKRLKVDKVDVF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 122 FAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDRLSLHKPVVEQPQYNMMVRD------------ 189
Cdd:cd19075  101 YLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKENGWVLPTVYQGMYNAITRQvetelfpclrkl 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 190 --RFeweyesvFAsgygstiWSPLYQGLLTGKY--NDDILADGRFnNSDNIYVKHfYQQILGDPEkrtkIQNQLKQLGEV 265
Cdd:cd19075  181 giRF-------YA-------YSPLAGGFLTGKYkySEDKAGGGRF-DPNNALGKL-YRDRYWKPS----YFEALEKVEEA 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 266 AKELGVTQAQLSLAW-----ALKNKDVSTAITSATRPEQLEETVKSVQ-------VVKLI 313
Cdd:cd19075  241 AEKEGISLAEAALRWlyhhsALDGEKGDGVILGASSLEQLEENLAALEkgplpeeVVKAI 300
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
11-306 2.11e-41

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 144.54  E-value: 2.11e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  11 LKVSAISYGNWV--NSDDKDTQDRN-TKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTlnvQRQDIVISTKIyGGD 87
Cdd:cd19086    1 LEVSEIGFGTWGlgGDWWGDVDDAEaIRALRAALDLGINFFDTADVYGDGHSERLLGKALKG---RRDKVVIATKF-GNR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  88 GNDFPN-SKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQ-TPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAI 165
Cdd:cd19086   77 FDGGPErPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPPDEvLDNDELFEALEKLKQEGKIRAYGVSVGDPEEALAAL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 166 --GICDrlslhkpvVEQPQYNMMVRDRFEWEYESVFASGYGSTIWSPLYQGLLTGKYnddiladgrfnnsdniyvkhfyq 243
Cdd:cd19086  157 rrGGID--------VVQVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASGLLTGKL----------------------- 205
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124399033 244 qilgdpekrtkiqnqlkqlgevakelgvtqAQLSLAWALKNKDVSTAITSATRPEQLEETVKS 306
Cdd:cd19086  206 ------------------------------AQAALRFILSHPAVSTVIPGARSPEQVEENAAA 238
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
10-308 1.67e-40

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 143.14  E-value: 1.67e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNW----VNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKtlNVQRQDIVISTKIYg 85
Cdd:cd19072    1 GEEVPVLGLGTWgiggGMSKDYSDDKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIK--GFDREDLFITTKVS- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  86 gdgndfPNskYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAI 165
Cdd:cd19072   78 ------PD--HLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQ 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 166 GICDRlslHKPVVEQPQYNMMVR----DRFEWEYE---SVFAsgygstiWSPLYQGLLTGKYNDDILAdgrfnnsdniyv 238
Cdd:cd19072  150 SYLKK---GPIVANQVEYNLFDReeesGLLPYCQKngiAIIA-------YSPLEKGKLSNAKGSPLLD------------ 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 239 khfyqqilgdpekrtkiqnqlkqlgEVAKELGVTQAQLSLAWaLKNKDVSTAITSATRPEQLEETVKSVQ 308
Cdd:cd19072  208 -------------------------EIAKKYGKTPAQIALNW-LISKPNVIAIPKASNIEHLEENAGALG 251
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
6-325 3.77e-40

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 143.20  E-value: 3.77e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   6 LGATGLKVSAISYGN----WVNSDDKDTqdrnTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLnvqRQDIVIST 81
Cdd:cd19102    1 LTTIGLGTWAIGGGGwgggWGPQDDRDS----IAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGL---RDRPIVAT 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  82 K---IYGGDGndfPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTA 158
Cdd:cd19102   74 KcglLWDEEG---RIRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 159 QQIH--QAIGICDRLslhkpvveQPQYNMMVRD------RFEWEYesvfasGYGSTIWSPLYQGLLTGKYNDDILA---- 226
Cdd:cd19102  151 DQMKrcQAIHPIASL--------QPPYSLLRRGieaeilPFCAEH------GIGVIVYSPMQSGLLTGKMTPERVAslpa 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 227 -DGRFNNSDniyvkhFYQQILGdpeKRTKIQNQLKQlgeVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVK 305
Cdd:cd19102  217 dDWRRRSPF------FQEPNLA---RNLALVDALRP---IAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVG 284
                        330       340
                 ....*....|....*....|
gi 124399033 306 SVQVVklITKEVEQKIESIL 325
Cdd:cd19102  285 AADLR--LTPEELAEIEALL 302
YdhF COG4989
Predicted oxidoreductase YdhF [General function prediction only];
1-283 3.51e-39

Predicted oxidoreductase YdhF [General function prediction only];


Pssm-ID: 444013 [Multi-domain]  Cd Length: 299  Bit Score: 140.67  E-value: 3.51e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNW-VNSDDKDTQDRNTKIiQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVI 79
Cdd:COG4989    1 MKRIKLGASGLSVSRIVLGCMrLGEWDLSPAEAAALI-EAALELGITTFDHADIYGGYTCEALFGEALKLSPSLREKIEL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  80 STK---IYGGDGNDFPNSKY-LSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSE 155
Cdd:COG4989   80 QTKcgiRLPSEARDNRVKHYdTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELKASGKVRHFGVSN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 156 WTAQQIhqaigicdRL---SLHKP-VVEQPQYNMMVRDRFEweyesvfasgyGSTI------------WSPLYQGLLTGK 219
Cdd:COG4989  160 FTPSQF--------ELlqsALDQPlVTNQIELSLLHTDAFD-----------DGTLdycqlngitpmaWSPLAGGRLFGG 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124399033 220 YNDDiladgrfnnsdniyvkhfyqqilgdpEKRTKiqnqlKQLGEVAKELGVTQAQLSLAWALK 283
Cdd:COG4989  221 FDEQ--------------------------FPRLR-----AALDELAEKYGVSPEAIALAWLLR 253
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
17-318 3.06e-38

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 138.13  E-value: 3.06e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  17 SYGNWVNSDDKDTQDrntkIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVqRQDIVISTKIYGgdgndFPNSky 96
Cdd:cd19093   16 LWWGYGEYGDEDLQA----AFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGD-RDEVVIATKFAP-----LPWR-- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  97 LSRKHLIEGLRNSLKRLDTPYVDIVFAHRYD-YQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIgicDRLSLHK 175
Cdd:cd19093   84 LTRRSVVKALKASLERLGLDSIDLYQLHWPGpWYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAH---KALKERG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 176 --PVVEQPQYNMMVRDRFEWEYESVfASGYGSTI--WSPLYQGLLTGKYNDDILADGRfnnsdniYVKHFYQQILgdpek 251
Cdd:cd19093  161 vpLASNQVEYSLLYRDPEQNGLLPA-CDELGITLiaYSPLAQGLLTGKYSPENPPPGG-------RRRLFGRKNL----- 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124399033 252 rTKIQNQLKQLGEVAKELGVTQAQLSLAWaLKNKDVsTAITSATRPEQLEETVKSVQvVKLITKEVE 318
Cdd:cd19093  228 -EKVQPLLDALEEIAEKYGKTPAQVALNW-LIAKGV-VPIPGAKNAEQAEENAGALG-WRLSEEEVA 290
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
1-307 2.16e-37

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 134.63  E-value: 2.16e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVnsddkdTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTlnVQRQDIVIS 80
Cdd:cd19105    1 MPYRTLGKTGLKVSRLGFGGGG------LPRESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKG--LRRDKVFLA 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  81 TKIYGGDGNDfpnskylSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPL---EETCRAFDWIIRHGLAHYWGTSE-- 155
Cdd:cd19105   73 TKASPRLDKK-------DKAELLKSVEESLKRLQTDYIDIYQLHGVDTPEERllnEELLEALEKLKKEGKVRFIGFSThd 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 156 WTAQQIHQAIGiCDRLSlhkpvVEQPQYNMMvrdRFEWEYESVFASGYGSTIwsplyqGLLTGKynddILADGrfnnsdn 235
Cdd:cd19105  146 NMAEVLQAAIE-SGWFD-----VIMVAYNFL---NQPAELEEALAAAAEKGI------GVVAMK----TLAGG------- 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124399033 236 iyvkhfYQQILGDPEKRTKiqnqlkqlgevakelGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSV 307
Cdd:cd19105  200 ------YLQPALLSVLKAK---------------GFSLPQAALKWVLSNPRVDTVVPGMRNFAELEENLAAA 250
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
26-305 8.63e-37

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 134.22  E-value: 8.63e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  26 DKDTQDRNTKIIQKAWELGINFFDTAEIYGD----GKAEIHLGHALKTLNVqRQDIVISTKiyGG-DGNDFPNSKYLSRK 100
Cdd:cd19082   12 TRIDEEEAFALLDAFVELGGNFIDTARVYGDwverGASERVIGEWLKSRGN-RDKVVIATK--GGhPDLEDMSRSRLSPE 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 101 HLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDRLSLHKPVVEQ 180
Cdd:cd19082   89 DIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASNWSTERIAEANAYAKAHGLPGFAASS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 181 PQYNMMVRDRFEWEYES------------------VFAsgygstiWSPLYQGLLTGKYN----DDILADGRFNNSDNIyv 238
Cdd:cd19082  169 PQWSLARPNEPPWPGPTlvamdeemrawheenqlpVFA-------YSSQARGFFSKRAAggaeDDSELRRVYYSEENF-- 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124399033 239 khfyqqilgdpEKRTKIQnqlkqlgEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVK 305
Cdd:cd19082  240 -----------ERLERAK-------ELAEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLA 288
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
8-309 1.41e-35

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 130.75  E-value: 1.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   8 ATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQRQDIVISTK--IYG 85
Cdd:cd19092    1 PEGLEVSRLVLGCMRLADWGESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNPGLREKIEIQTKcgIRL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  86 GDGNDFPNSKY--LSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIH- 162
Cdd:cd19092   81 GDDPRPGRIKHydTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQIEl 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 163 -QAigicdRLSlHKPVVEQPQYNMMvrdRFEWEYESV--FASGYGSTI--WSPLYQGLLTGkynddiladgrfnnsdniy 237
Cdd:cd19092  161 lQS-----YLD-QPLVTNQIELSLL---HTEAIDDGTldYCQLLDITPmaWSPLGGGRLFG------------------- 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124399033 238 vkhfyqqilgdpEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQV 309
Cdd:cd19092  213 ------------GFDERFQRLRAALEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDI 272
AKR_unchar cd19752
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
44-307 2.05e-33

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381391 [Multi-domain]  Cd Length: 291  Bit Score: 125.14  E-value: 2.05e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  44 GINFFDTAEIYG-------DGKAEIHLGHALKTLNVqRQDIVISTKI---YGGDGNDFPNSKYLSRKHLIEGLRNSLKRL 113
Cdd:cd19752   30 GGNFLDTANNYAfwteggvGGESERLIGRWLKDRGN-RDDVVIATKVgagPRDPDGGPESPEGLSAETIEQEIDKSLRRL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 114 DTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDRLSLHKPVVEQPQYNmMVRDRFEW 193
Cdd:cd19752  109 GTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWRLERARQIARQQGWAEFSAIQQRHS-YLRPRPGA 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 194 EYESVFASG-----YGS-----TIWSplYQGLLTGKY-NDDILADGRFNNSDNiyvkhfyqqilgdpekrtkiQNQLKQL 262
Cdd:cd19752  188 DFGVQRIVTdelldYASsrpdlTLLA--YSPLLSGAYtRPDRPLPEQYDGPDS--------------------DARLAVL 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 124399033 263 GEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSV 307
Cdd:cd19752  246 EEVAGELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAAL 290
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
2-324 1.15e-32

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 123.91  E-value: 1.15e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   2 EYRRLGATGLKVSAISYGN------WVNSDDkDTQDRntkIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLnvqRQ 75
Cdd:cd19104    1 KYRRFGRTGLKVSELTFGGggigglMGRTTR-EEQIA---AVRRALDLGINFFDTAPSYGDGKSEENLGRALKGL---PA 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  76 DIVISTKIygGDGNDFPNSKYlsrKHLIEGLRNSLKRLDTPYVDIVFAH------RYDYQTP---------LEETCRAFD 140
Cdd:cd19104   74 GPYITTKV--RLDPDDLGDIG---GQIERSVEKSLKRLKRDSVDLLQLHnrigdeRDKPVGGtlsttdvlgLGGVADAFE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 141 WIIRHGLAHYWGTSEW-TAQQIHQAIGiCDRLSLhkpvVEQPqYNMMVRDRFEWEYESVFASGYGSTI------------ 207
Cdd:cd19104  149 RLRSEGKIRFIGITGLgNPPAIRELLD-SGKFDA----VQVY-YNLLNPSAAEARPRGWSAQDYGGIIdaaaehgvgvmg 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 208 WSPLYQGLLTGKYNDDILADgrfNNSDNIYVKHFyqqilgdpekrtkiqNQLKQLGEVAKELGVTQAQLSLAWALKNKDV 287
Cdd:cd19104  223 IRVLAAGALTTSLDRGREAP---PTSDSDVAIDF---------------RRAAAFRALAREWGETLAQLAHRFALSNPGV 284
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 124399033 288 STAITSATRPEQLEETVKSVQVVKLiTKEVEQKIESI 324
Cdd:cd19104  285 STVLVGVKNREELEEAVAAEAAGPL-PAENLARLEAL 320
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
8-316 2.73e-32

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 121.59  E-value: 2.73e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   8 ATGLKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTlnvQRQDIVISTKIYggd 87
Cdd:cd19138    6 PDGTKVPALGQGTWYMGEDPAKRAQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRG---RRDKVFLVSKVL--- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  88 gndfP-NSkylSRKHLIEGLRNSLKRLDTPYVDIVFAH-RYDYqtPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAI 165
Cdd:cd19138   80 ----PsNA---SRQGTVRACERSLRRLGTDYLDLYLLHwRGGV--PLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELW 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 166 GIcdrLSLHKPVVEQPQYNMMVR----DRFEWEYE-SVFASGYgstiwSPLYQGlltgkyndDILADGRFNNSDniyvkh 240
Cdd:cd19138  151 AV---PGGGNCAANQVLYNLGSRgieyDLLPWCREhGVPVMAY-----SPLAQG--------GLLRRGLLENPT------ 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124399033 241 fyqqilgdpekrtkiqnqlkqLGEVAKELGVTQAQLSLAWALKNKDVsTAITSATRPEQLEETVKSVQVVklITKE 316
Cdd:cd19138  209 ---------------------LKEIAARHGATPAQVALAWVLRDGNV-IAIPKSGSPEHARENAAAADLE--LTEE 260
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
1-307 6.24e-32

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 121.12  E-value: 6.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYG------NWVNSDDKDTqdrnTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKtlNVQR 74
Cdd:cd19163    1 MKYRKLGKTGLKVSKLGFGasplggVFGPVDEEEA----IRTVHEALDSGINYIDTAPWYGQGRSETVLGKALK--GIPR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  75 QDIVISTKI--YGGDGN---DFpnskylSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTP----LEETCRAFDWIIRH 145
Cdd:cd19163   75 DSYYLATKVgrYGLDPDkmfDF------SAERITKSVEESLKRLGLDYIDIIQVHDIEFAPSldqiLNETLPALQKLKEE 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 146 GLAHYwgtsewtaqqihqaIGICDR-LSLHKPVVEQPQ-----------YNMMvrDRFEWEYESVFAS-GYGSTIWSPLY 212
Cdd:cd19163  149 GKVRF--------------IGITGYpLDVLKEVLERSPvkidtvlsychYTLN--DTSLLELLPFFKEkGVGVINASPLS 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 213 QGLLTGKynddiladgrfnnsdniyvkhfyqqilGDPE---KRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVST 289
Cdd:cd19163  213 MGLLTER---------------------------GPPDwhpASPEIKEACAKAAAYCKSRGVDISKLALQFALSNPDIAT 265
                        330
                 ....*....|....*...
gi 124399033 290 AITSATRPEQLEETVKSV 307
Cdd:cd19163  266 TLVGTASPENLRKNLEAA 283
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
10-325 3.09e-31

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 119.72  E-value: 3.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWV-------NSDDKdtQDRNTkiIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvQRQDIVISTK 82
Cdd:cd19148    1 DLPVSRIALGTWAiggwmwgGTDEK--EAIET--IHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYG-KRDRVVIATK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  83 I---YGGDGNDFPNSkylSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQ 159
Cdd:cd19148   76 VgleWDEGGEVVRNS---SPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 160 QIhqaigicDRLSLHKPV-VEQPQYNMmvrdrFEWEYES-----VFASGYGSTIWSPLYQGLLTGKYN-DDILADGRFNN 232
Cdd:cd19148  153 QM-------ETFRKVAPLhTVQPPYNL-----FEREIEKdvlpyARKHNIVTLAYGALCRGLLSGKMTkDTKFEGDDLRR 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 233 SDNIYVKHFYQQILGDPEkrtkiqnQLKQLgevAKE-LGVTQAQLSLAWALKNKDVSTAITSATRPEQLEEtVKSVQVVK 311
Cdd:cd19148  221 TDPKFQEPRFSQYLAAVE-------ELDKL---AQErYGKSVIHLAVRWLLDQPGVSIALWGARKPEQLDA-VDEVFGWS 289
                        330
                 ....*....|....
gi 124399033 312 LiTKEVEQKIESIL 325
Cdd:cd19148  290 L-NDEDMKEIDAIL 302
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
14-308 5.28e-31

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 118.43  E-value: 5.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  14 SAISYGN-WVNSDDKD-TQDRNTKIIQKAWELGINFFDTAEIYGDgkAEIHLGHALKTlnVQRQDIVISTKI--YGGDGN 89
Cdd:cd19090    1 SALGLGTaGLGGVFGGvDDDEAVATIRAALDLGINYIDTAPAYGD--SEERLGLALAE--LPREPLVLSTKVgrLPEDTA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  90 DFpnskylSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCR--AFDWIIR---HGLAHYWGTSEWTAQQIHQA 164
Cdd:cd19090   77 DY------SADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDILAPggALEALLElkeEGLIKHIGLGGGPPDLLRRA 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 165 I--GICDRLSLHKpvveqpQYNMMVRDRFeweyESVF--ASGYGSTIW--SPLYQGLLTGKYNDdiladgrfnnsdniYV 238
Cdd:cd19090  151 IetGDFDVVLTAN------RYTLLDQSAA----DELLpaAARHGVGVInaSPLGMGLLAGRPPE--------------RV 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 239 KHFYQQILgdpekrTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQ 308
Cdd:cd19090  207 RYTYRWLS------PELLDRAKRLYELCDEHGVPLPALALRFLLRDPRISTVLVGASSPEELEQNVAAAE 270
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
1-329 8.42e-31

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 119.08  E-value: 8.42e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNS---DDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvqRQDI 77
Cdd:cd19144    1 IPTRTLGRNGPSVPALGFGAMGLSafyGPPKPDEERFAVLDAAFELGCTFWDTADIYGDSEELIGRWFKQNPGK--REKI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  78 VISTKiYGG-----DGNDFPNSkylSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWG 152
Cdd:cd19144   79 FLATK-FGIeknveTGEYSVDG---SPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIG 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 153 TSEWTAQQIHQAIGIcdrlslhKPV-------------VEQPQYNMMVRDRfeweyesvfASGYGSTIWSPLYQGLLTGK 219
Cdd:cd19144  155 LSECSAETLRRAHAV-------HPIaavqieyspfsldIERPEIGVLDTCR---------ELGVAIVAYSPLGRGFLTGA 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 220 YND-DILADGRFNNsdniYVKHFyqqilgDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPE 298
Cdd:cd19144  219 IRSpDDFEEGDFRR----MAPRF------QAENFPKNLELVDKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLK 288
                        330       340       350
                 ....*....|....*....|....*....|.
gi 124399033 299 QLEETVKSVQvVKLiTKEVEQKIESILSNKP 329
Cdd:cd19144  289 RLEENLGALK-VKL-TEEEEKEIREIAEEAE 317
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
10-309 3.35e-30

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 115.75  E-value: 3.35e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNW----VNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKtlNVQRQDIVISTKIYg 85
Cdd:cd19137    1 GEKIPALGLGTWgiggFLTPDYSRDEEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIK--DFPREDLFIVTKVW- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  86 gdgndfpnSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAI 165
Cdd:cd19137   78 --------PTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAI 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 166 GICdrlslHKP-VVEQPQYNMMVRDrfeweyesvfasgygstiwsPLYQGLLtgkynddiladgRFNNSDNIYVKHFyqq 244
Cdd:cd19137  150 SKS-----QTPiVCNQVKYNLEDRD--------------------PERDGLL------------EYCQKNGITVVAY--- 189
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124399033 245 ilgDPEKRT--KIQNQLKQlgeVAKELGVTQAQLSLAWALKNKDVsTAITSATRPEQLEETVKSVQV 309
Cdd:cd19137  190 ---SPLRRGleKTNRTLEE---IAKNYGKTIAQIALAWLIQKPNV-VAIPKAGRVEHLKENLKATEI 249
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
10-302 2.46e-28

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 110.53  E-value: 2.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWvNSDDKDTQDrntkIIQKAWELGINFFDTAEIYGdgkAEIHLGHALKTLNVQRQDIVISTKIYGGDgn 89
Cdd:COG0656    2 GVEIPALGLGTW-QLPGEEAAA----AVRTALEAGYRHIDTAAMYG---NEEGVGEAIAASGVPREELFVTTKVWNDN-- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  90 dfpnskyLSRKHLIEGLRNSLKRLDTPYVDIVFAH-RYDYqtPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGIC 168
Cdd:COG0656   72 -------HGYDDTLAAFEESLERLGLDYLDLYLIHwPGPG--PYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAET 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 169 DrlslHKPVVEQPQYNMmvrdrFEWEYESV-FASGYGSTI--WSPLYQGlltgkynddiladgrfnnsdniyvkhfyqQI 245
Cdd:COG0656  143 G----VKPAVNQVELHP-----YLQQRELLaFCREHGIVVeaYSPLGRG-----------------------------KL 184
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124399033 246 LGDPEkrtkiqnqlkqLGEVAKELGVTQAQLSLAWALkNKDVStAITSATRPEQLEE 302
Cdd:COG0656  185 LDDPV-----------LAEIAEKHGKTPAQVVLRWHL-QRGVV-VIPKSVTPERIRE 228
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
1-305 2.06e-27

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 110.29  E-value: 2.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYG--NWVNSDdkdtQDRNTKIIQKAWELGINFFDTAeiYGDGKAEIHLGHALKTLnvqRQDIV 78
Cdd:COG1453    1 MQYRRLGKTGLEVSVLGFGgmRLPRKD----EEEAEALIRRAIDNGINYIDTA--RGYGDSEEFLGKALKGP---RDKVI 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  79 ISTKIyggdgndfpNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAH----RYDYQTPLEETcRAFDWI--------IRHg 146
Cdd:COG1453   72 LATKL---------PPWVRDPEDMRKDLEESLKRLQTDYIDLYLIHglntEEDLEKVLKPG-GALEALekakaegkIRH- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 147 lahywgtsewtaqqihqaIGIC--DRLSLHKPVVE-------QPQYNMM-VRDRFEWE-YESVFASGYGSTIWSPlyqgl 215
Cdd:COG1453  141 ------------------IGFSthGSLEVIKEAIDtgdfdfvQLQYNYLdQDNQAGEEaLEAAAEKGIGVIIMKP----- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 216 ltgkynddiLADGRFNNsdniyvkhfyqqilgDPEKRTKIqnqlkqlgevaKELGVTQAQLSLAWALKNKDVSTAITSAT 295
Cdd:COG1453  198 ---------LKGGRLAN---------------PPEKLVEL-----------LCPPLSPAEWALRFLLSHPEVTTVLSGMS 242
                        330
                 ....*....|
gi 124399033 296 RPEQLEETVK 305
Cdd:COG1453  243 TPEQLDENLK 252
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
3-124 5.43e-27

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 106.41  E-value: 5.43e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   3 YRRLGATGLKVSAISYGNWVNSddKDTQDRNTKIIQKAWELGINFFDTAEIYGDgkAEIHLGHALKTlnvQRQDIVISTK 82
Cdd:cd19100    1 YRRLGRTGLKVSRLGFGGGPLG--RLSQEEAAAIIRRALDLGINYFDTAPSYGD--SEEKIGKALKG---RRDKVFLATK 73
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 124399033  83 IYGGDGNDFpnskylsRKHliegLRNSLKRLDTPYVDIVFAH 124
Cdd:cd19100   74 TGARDYEGA-------KRD----LERSLKRLGTDYIDLYQLH 104
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
13-310 6.43e-27

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 106.92  E-value: 6.43e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  13 VSAISYGNW------VNSDDKDtQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTlnvQRQDIVISTKI--- 83
Cdd:cd19088    1 VSRLGYGAMrltgpgIWGPPAD-REEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHP---YPDDVVIATKGglv 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  84 YGGDGNDFPNSkylSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQ 163
Cdd:cd19088   77 RTGPGWWGPDG---SPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 164 AIGICDRLSLhkpvveQPQYNMMVRDRfeweyESVFAS----GYGSTIWSPLyqglltgkynddiladGRFnnsdniyvk 239
Cdd:cd19088  154 ARAIVRIVSV------QNRYNLANRDD-----EGVLDYceaaGIAFIPWFPL----------------GGG--------- 197
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124399033 240 hfyqqilGDPEKRTKiqnqlkqLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVV 310
Cdd:cd19088  198 -------DLAQPGGL-------LAEVAARLGATPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAAGLR 254
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
4-319 1.13e-26

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 107.13  E-value: 1.13e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   4 RRLGATGLKVSAISYG-----NWVNSDDKDTQdrNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLnvQRQDIV 78
Cdd:cd19145    3 VKLGSQGLEVSAQGLGcmglsGDYGAPKPEEE--GIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDG--PREKVQ 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  79 ISTK--IYGGDGndfpnSKYLSR---KHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGT 153
Cdd:cd19145   79 LATKfgIHEIGG-----SGVEVRgdpAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 154 SEWTAQQIHQAIGIcdrlslHKPVVEQPQYNMMVRDRFEWEYESVFASGYGSTIWSPLYQGLLTGKyndDILADgrfNNS 233
Cdd:cd19145  154 SEASADTIRRAHAV------HPITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGK---AKLEE---LLE 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 234 DNIYVKHF--YQQilgdpEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQvVK 311
Cdd:cd19145  222 NSDVRKSHprFQG-----ENLEKNKVLYERVEALAKKKGCTPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIGALS-VK 295

                 ....*...
gi 124399033 312 LITKEVEQ 319
Cdd:cd19145  296 LTKEDLKE 303
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
6-306 1.08e-25

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 103.47  E-value: 1.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   6 LGATGLkvsaisYGNWVNSDDKDTQDrntkIIQKAWELGINFFDTAEIYGDgkAEIHLGHALKTLnvQRQDIVISTKI-- 83
Cdd:cd19095    5 LGTSGI------GRVWGVPSEAEAAR----LLNTALDLGINLIDTAPAYGR--SEERLGRALAGL--RRDDLFIATKVgt 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  84 ---YGGDGNDFpnskylSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYwgtsewtaqq 160
Cdd:cd19095   71 hgeGGRDRKDF------SPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRY---------- 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 ihqaIGICDRLSLHKPVVE-------QPQYNMMVRDRfeweyESVF----ASGYGSTIWSPLYQGLLTGKYNDDILADgr 229
Cdd:cd19095  135 ----IGVSGDGEELEAAIAsgvfdvvQLPYNVLDREE-----EELLplaaEAGLGVIVNRPLANGRLRRRVRRRPLYA-- 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124399033 230 fnnsdniyvkhfyqqilgdpekrtkiqnQLKQLGEVAKELGV-TQAQLSLAWALKNKDVSTAITSATRPEQLEETVKS 306
Cdd:cd19095  204 ----------------------------DYARRPEFAAEIGGaTWAQAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
PLN02587 PLN02587
L-galactose dehydrogenase
3-326 1.15e-23

L-galactose dehydrogenase


Pssm-ID: 178198 [Multi-domain]  Cd Length: 314  Bit Score: 99.08  E-value: 1.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   3 YRRLGATGLKVSAISYG--------NWVNSDDKdtqdrnTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQR 74
Cdd:PLN02587   1 LRELGSTGLKVSSVGFGasplgsvfGPVSEEDA------IASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALGIPR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  75 QDIVISTKI--YgGDGNDFpnskylSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQT---PLEETCRAFDWIIRHGLAH 149
Cdd:PLN02587  75 EKYVVSTKCgrY-GEGFDF------SAERVTKSVDESLARLQLDYVDILHCHDIEFGSldqIVNETIPALQKLKESGKVR 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 150 YWGTSEWTaqqihqaIGIC----DRLSLHKPVVEQPQYNMMVRDRFEWEYESVFAS-GYGSTIWSPLYQGLLTGKynddi 224
Cdd:PLN02587 148 FIGITGLP-------LAIFtyvlDRVPPGTVDVILSYCHYSLNDSSLEDLLPYLKSkGVGVISASPLAMGLLTEN----- 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 225 ladgrfnnsdniyvkhfyqqilGDPE---KRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLE 301
Cdd:PLN02587 216 ----------------------GPPEwhpAPPELKSACAAAATHCKEKGKNISKLALQYSLSNKDISTTLVGMNSVQQVE 273
                        330       340
                 ....*....|....*....|....*..
gi 124399033 302 ETVKSVQVVKL--ITKEVEQKIESILS 326
Cdd:PLN02587 274 ENVAAATELETsgIDEELLSEVEAILA 300
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
10-302 2.40e-22

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 94.25  E-value: 2.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWVNSDDKdtqdrNTKIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYggdgn 89
Cdd:cd19140    5 GVRIPALGLGTYPLTGEE-----CTRAVEHALELGYRHIDTAQMYGN---EAQVGEAIAASGVPRDELFLTTKVW----- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  90 dFPNskyLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIgicd 169
Cdd:cd19140   72 -PDN---YSPDDFLASVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAV---- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 170 RLSLHKPVVEQPQYNMMVRDRfeweyeSVFAS----GYGSTIWSPlyqglltgkynddiLADGRfnnsdniyvkhfyqqI 245
Cdd:cd19140  144 ELSEAPLFTNQVEYHPYLDQR------KLLDAarehGIALTAYSP--------------LARGE---------------V 188
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124399033 246 LGDPEkrtkiqnqlkqLGEVAKELGVTQAQLSLAWALKNKDVStAITSATRPEQLEE 302
Cdd:cd19140  189 LKDPV-----------LQEIGRKHGKTPAQVALRWLLQQEGVA-AIPKATNPERLEE 233
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
9-310 1.05e-21

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 93.46  E-value: 1.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYG----NWvnSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHL---GHALKTLNVQRQDIVIST 81
Cdd:cd19077    1 NGKLVGPIGLGlmglTW--RPNPTPDEEAFETMKAALDAGSNLWNGGEFYGPPDPHANLkllARFFRKYPEYADKVVLSV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  82 KiyGG--DGNDFPNSkylSRKHLIEGLRNSLKRLD-TPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTA 158
Cdd:cd19077   79 K--GGldPDTLRPDG---SPEAVRKSIENILRALGgTKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSEVSA 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 159 QQIHQAigicdrLSLHKPVVEQPQYNMMVRDRFEWE-YESVFASGYGSTIWSPLYQGLLTGKY-NDDILADGRFnnsdNI 236
Cdd:cd19077  154 ETIRRA------HAVHPIAAVEVEYSLFSREIEENGvLETCAELGIPIIAYSPLGRGLLTGRIkSLADIPEGDF----RR 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124399033 237 YVKHFyqqilgDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALK-NKDVSTAITSATRPEQLEETVKSVQVV 310
Cdd:cd19077  224 HLDRF------NGENFEKNLKLVDALQELAEKKGCTPAQLALAWILAqSGPKIIPIPGSTTLERVEENLKAANVE 292
tas PRK10625
putative aldo-keto reductase; Provisional
1-324 1.18e-21

putative aldo-keto reductase; Provisional


Pssm-ID: 236727 [Multi-domain]  Cd Length: 346  Bit Score: 94.15  E-value: 1.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLGATGLKVSAISYGNWVNSDDKDTQDRNTKIiQKAWELGINFFDTAEIY-------GDGKAEIHLGHALKTLNvQ 73
Cdd:PRK10625   1 MQYHRIPHSSLEVSTLGLGTMTFGEQNSEADAHAQL-DYAVAQGINLIDVAEMYpvpprpeTQGLTETYIGNWLAKRG-S 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  74 RQDIVISTKIYG-GDGNDF---PNsKYLSRKHLIEGLRNSLKRLDTPYVDIVFAH--------------RYDYQTP---L 132
Cdd:PRK10625  79 REKLIIASKVSGpSRNNDKgirPN-QALDRKNIREALHDSLKRLQTDYLDLYQVHwpqrptncfgklgySWTDSAPavsL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 133 EETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDRLSLHKPVVEQPQYNMMVRDrFE------WEYESVFASGYgst 206
Cdd:PRK10625 158 LETLDALAEQQRAGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNRS-FEvglaevSQYEGVELLAY--- 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 207 iwSPLYQGLLTGKYNDDILADGRFNNSDNIYVKHFYQQilgdpekrtkIQNQLKQLGEVAKELGVTQAQLSLAWALKNKD 286
Cdd:PRK10625 234 --SCLAFGTLTGKYLNGAKPAGARNTLFSRFTRYSGEQ----------TQKAVAAYVDIAKRHGLDPAQMALAFVRRQPF 301
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 124399033 287 VSTAITSATRPEQLEETVKSVQVVklITKEVEQKIESI 324
Cdd:PRK10625 302 VASTLLGATTMEQLKTNIESLHLT--LSEEVLAEIEAV 337
AKR_AKR15A1 cd19161
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ...
36-308 1.77e-21

Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.


Pssm-ID: 381387 [Multi-domain]  Cd Length: 310  Bit Score: 93.16  E-value: 1.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  36 IIQKAWELGINFFDTAEIYGDGKAEIHLGHALKtlNVQRQDIVISTKIygG------------DGNDFPNS-------KY 96
Cdd:cd19161   25 TLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLR--EKPRDEFVLSTKV--GrllkparegsvpDPNGFVDPlpfeivyDY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  97 lSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGlaHYWGTSEWTAQQIHQAIG-------ICD 169
Cdd:cd19161  101 -SYDGIMRSFEDSLQRLGLNRIDILYVHDIGVYTHGDRKERHHFAQLMSG--GFKALEELKKAGVIKAFGlgvnevqICL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 170 RLSlhkpvvEQPQYN-MMVRDRFeweyesvfaSGYGSTIWSPLYQG--------LLTGKYNDDILADGRFNNSdniyvkh 240
Cdd:cd19161  178 EAL------DEADLDcFLLAGRY---------SLLDQSAEEEFLPRceqrgtslVIGGVFNSGILATGTKSGA------- 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124399033 241 FYQQILGDPEkrtkIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQ 308
Cdd:cd19161  236 KFNYGDAPAE----IISRVMEIEKICDAYNVPLAAAALQFPLRHPAVASVLTGARNPAQLRQNVEAFQ 299
AKR_AKR9A1-2 cd19146
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ...
10-325 4.45e-21

Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.


Pssm-ID: 381372 [Multi-domain]  Cd Length: 326  Bit Score: 92.10  E-value: 4.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVS-----AISYGN-WVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvQRQDIVISTKI 83
Cdd:cd19146    8 GVRVSplclgAMSFGEaWKSMMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRG-NRDEMVLATKY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  84 ---YGGDGNDFPNSKYL--SRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTA 158
Cdd:cd19146   87 ttgYRRGGPIKIKSNYQgnHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVLYLGVSDTPA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 159 QQIHQAIGICDRLSLHKPVVEQPQYNMMVRDrFEWEYESV-FASGYGSTIWSPLYQGlltgkyndDILADGRFNNSDNIY 237
Cdd:cd19146  167 WVVSKANAYARAHGLTQFVVYQGHWSAAFRD-FERDILPMcEAEGMALAPWGVLGQG--------QFRTEEEFKRRGRSG 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 238 VKHFYQQilgdpEKRTKIQnqlKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklITKEV 317
Cdd:cd19146  238 RKGGPQT-----EKERKVS---EKLEKVAEEKGTAITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGIS--LSDEE 307

                 ....*...
gi 124399033 318 EQKIESIL 325
Cdd:cd19146  308 IQEIEDAY 315
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
10-319 5.22e-21

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 91.14  E-value: 5.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGN---WVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYGG 86
Cdd:cd19120    1 GSKIPAIAFGTgtaWYKSGDDDIQRDLVDSVKLALKAGFRHIDTAEMYGN---EKEVGEALKESGVPREDLFITTKVSPG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  87 DGNdfpnskylsrkhlIEG-LRNSLKRLDTPYVDIVFAH----RYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQI 161
Cdd:cd19120   78 IKD-------------PREaLRKSLAKLGVDYVDLYLIHspffAKEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 162 HQAIGICDrlslHKPVVEQPQYNMMVRDRFE--WEY---ESVFASGYGSTiwSPLYQGlltgkynddilADGRFNnsdni 236
Cdd:cd19120  145 EELLDTAK----IKPAVNQIEFHPYLYPQQPalLEYcreHGIVVSAYSPL--SPLTRD-----------AGGPLD----- 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 237 yvkhfyqqilgdpekrtkiqnqlKQLGEVAKELGVTQAQLSLAWALKnKDVsTAITSATRPEQLEETVKsVQVVKLITKE 316
Cdd:cd19120  203 -----------------------PVLEKIAEKYGVTPAQVLLRWALQ-KGI-VVVTTSSKEERMKEYLE-AFDFELTEEE 256

                 ...
gi 124399033 317 VEQ 319
Cdd:cd19120  257 VEE 259
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
15-302 5.28e-19

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 85.02  E-value: 5.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  15 AISYGNWvnsddKDTQDRNTKIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYggdgndfpnS 94
Cdd:cd19073    3 ALGLGTW-----QLRGDDCANAVKEALELGYRHIDTAEIYNN---EAEVGEAIAESGVPREDLFITTKVW---------R 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  95 KYLSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDRLslh 174
Cdd:cd19073   66 DHLRPEDLKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLP--- 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 175 kPVVEQPQYNMMVRDRFEWEYesvfASGYGSTI--WSPLYQGlltgkynddiladgrfnnsdniyvkhfyqQILGDPEkr 252
Cdd:cd19073  143 -IAVNQVEFHPFLYQAELLEY----CRENDIVItaYSPLARG-----------------------------EVLRDPV-- 186
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 124399033 253 tkiqnqlkqLGEVAKELGVTQAQLSLAWaLKNKDVStAITSATRPEQLEE 302
Cdd:cd19073  187 ---------IQEIAEKYDKTPAQVALRW-LVQKGIV-VIPKASSEDHLKE 225
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
36-323 2.70e-18

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 83.92  E-value: 2.70e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  36 IIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvqRQDIVISTKiyggdgndF-PNSKYLSRKHLIEGLRNSLKRLD 114
Cdd:cd19103   37 VFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYP--REDYIISTK--------FtPQIAGQSADPVADMLEGSLARLG 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 115 TPYVDIVFAHRydyQTPLEE-TCRAFDwIIRHGLAHYWGTSEWTAQQIHQAIGICDRLSLHKPVVeQPQYNMMVRDrfeW 193
Cdd:cd19103  107 TDYIDIYWIHN---PADVERwTPELIP-LLKSGKVKHVGVSNHNLAEIKRANEILAKAGVSLSAV-QNHYSLLYRS---S 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 194 EYESVFASGYGSTI----WSPLYQGLLTGKYNddiladgrfnnsdniyVKHFYQQILGDPEKRTKIQNQLKQL----GEV 265
Cdd:cd19103  179 EEAGILDYCKENGItffaYMVLEQGALSGKYD----------------TKHPLPEGSGRAETYNPLLPQLEELtavmAEI 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124399033 266 AKELGVTQAQLSLAWAL-KNkdvSTAITSATRPEQLEETVKSVQvVKLITKEVEQkIES 323
Cdd:cd19103  243 GAKHGASIAQVAIAWAIaKG---TTPIIGVTKPHHVEDAARAAS-ITLTDDEIKE-LEQ 296
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
17-312 4.81e-18

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 82.58  E-value: 4.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  17 SYGnWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDgkAEIHLGHALKTLnvqrQDIVISTKIyggdgNDFPNSKY 96
Cdd:cd19097   13 DYG-IANKSGKPSEKEAKKILEYALKAGINTLDTAPAYGD--SEKVLGKFLKRL----DKFKIITKL-----PPLKEDKK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  97 LSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYqtpLEETCRA-FDWIIRH---GLAHYWGTSEWTAQQIHQAigicdrLS 172
Cdd:cd19097   81 EDEAAIEASVEASLKRLKVDSLDGLLLHNPDD---LLKHGGKlVEALLELkkeGLIRKIGVSVYSPEELEKA------LE 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 173 LHKPVVEQPQYNMMvrDRfEWEYESVFASGYGSTIW----SPLYQGLLtgkynddiladgrFNNSDNIyvkhfyqqilgd 248
Cdd:cd19097  152 SFKIDIIQLPFNIL--DQ-RFLKSGLLAKLKKKGIEiharSVFLQGLL-------------LMEPDKL------------ 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124399033 249 PEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVKL 312
Cdd:cd19097  204 PAKFAPAKPLLKKLHELAKKLGLSPLELALGFVLSLPEIDKIVVGVDSLEQLKEIIAAFKKPPL 267
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
14-306 9.51e-18

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 81.45  E-value: 9.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  14 SAISYG------NWVNSDDkdtQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKtlNVQRQDIVISTKIyggd 87
Cdd:cd19096    1 SVLGFGtmrlpeSDDDSID---EEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALK--EGPREKFYLATKL---- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  88 gndfPNSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAH---RYDYQTPLEEtCRAFDWIIR---HGLAHYWG-TSEWTAQQ 160
Cdd:cd19096   72 ----PPWSVKSAEDFRRILEESLKRLGVDYIDFYLLHglnSPEWLEKARK-GGLLEFLEKakkEGLIRHIGfSFHDSPEL 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 161 IHQAI--GICDRLSLHkpvveqpqYNMMVRDRFEWE--YESVFASGYGSTIWSPLYQGLLTgkynddiladgrfnnsdni 236
Cdd:cd19096  147 LKEILdsYDFDFVQLQ--------YNYLDQENQAGRpgIEYAAKKGMGVIIMEPLKGGGLA------------------- 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 237 yvkhfyqqilgdpekrtkiqNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKS 306
Cdd:cd19096  200 --------------------NNPPEALAILCGAPLSPAEWALRFLLSHPEVTTVLSGMSTPEQLDENIAA 249
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
15-302 1.99e-17

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 80.60  E-value: 1.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  15 AISYGNWvNSDDKDTQDrntkIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIyggdgndfpNS 94
Cdd:cd19071    3 LIGLGTY-KLKPEETAE----AVLAALEAGYRHIDTAAAYGN---EAEVGEAIRESGVPREELFITTKL---------WP 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  95 KYLSRKHLIEGLRNSLKRLDTPYVDIVFAH------RYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGIC 168
Cdd:cd19071   66 TDHGYERVREALEESLKDLGLDYLDLYLIHwpvpgkEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAA 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 169 DrlslHKPVVEQpqynmmvrdrFEweyesvfasgygstiWSPLYQglltgkyNDDILAdgrFNNSDNIYV------KHFY 242
Cdd:cd19071  146 R----IKPAVNQ----------IE---------------LHPYLQ-------QKELVE---FCKEHGIVVqaysplGRGR 186
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 243 QQILGDPEkrtkiqnqlkqLGEVAKELGVTQAQLSLAWALkNKDVSTaITSATRPEQLEE 302
Cdd:cd19071  187 RPLLDDPV-----------LKEIAKKYGKTPAQVLLRWAL-QRGVVV-IPKSSNPERIKE 233
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
11-158 4.03e-17

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 80.82  E-value: 4.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  11 LKVSAISYGNWVNSDDKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTL----NVQRQDIVISTKiyGG 86
Cdd:cd19099    1 LTLSSLGLGTYRGDSDDETDEEYREALKAALDSGINVIDTAINYRGGRSERLIGKALRELiekgGIKRDEVVIVTK--AG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  87 ---DGNDFPNSKY-----------------------LSRKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTP--------- 131
Cdd:cd19099   79 yipGDGDEPLRPLkyleeklgrglidvadsaglrhcISPAYLEDQIERSLKRLGLDTIDLYLLHNPEEQLLelgeeefyd 158
                        170       180
                 ....*....|....*....|....*...
gi 124399033 132 -LEETCRAFDWIIRHGLAHYWGTSEWTA 158
Cdd:cd19099  159 rLEEAFEALEEAVAEGKIRYYGISTWDG 186
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
19-309 8.10e-17

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 79.96  E-value: 8.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  19 GN-WVNSDDKDTQDrntkIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvqRQDIVISTKIyG-------GDGND 90
Cdd:cd19152   11 GNlYEAVSDEEAKA----TLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELG--REDYVISTKV-GrllvplqEVEPT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  91 FPNSKYLSRKHLI------EGLRN----SLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIR-----------HGLAH 149
Cdd:cd19152   84 FEPGFWNPLPFDAvfdysyDGILRsiedSLQRLGLSRIDLLSIHDPDEDLAGAESDEHFAQAIKgafraleelreEGVIK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 150 YW--GTSEWT-AQQIHQAIG-----ICDRLSLhkpvVEQPQYnmmvrDRFeweYESVFASGYGSTIWSPlyqglltgkYN 221
Cdd:cd19152  164 AIglGVNDWEvILRILEEADldwvmLAGRYTL----LDHSAA-----REL---LPECEKRGVKVVNAGP---------FN 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 222 DDILADGRFNNSDNiyvkhfYQQilGDPEkrtkIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLE 301
Cdd:cd19152  223 SGFLAGGDNFDYYE------YGP--APPE----LIARRDRIEALCEQHGVSLAAAALQFALAPPAVASVAPGASSPERVE 290

                 ....*...
gi 124399033 302 ETVKSVQV 309
Cdd:cd19152  291 ENVALLAT 298
AKR_galDH-like cd19153
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...
4-315 1.78e-16

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381379 [Multi-domain]  Cd Length: 294  Bit Score: 78.73  E-value: 1.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   4 RRLGATGLKVSAIS---------YGNWVNSDDKDtqdrntKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNVQR 74
Cdd:cd19153    3 ETLEIALGNVSPVGlgtaalggvYGDGLEQDEAV------AIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQVPR 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  75 QDIVISTKI--YGGDGNDFpnskylSRKHLIEGLRNSLKRLDTPYVDIVFAHRY---DYQTPLEETCRAFdwiirhglah 149
Cdd:cd19153   77 SSYTVATKVgrYRDSEFDY------SAERVRASVATSLERLHTTYLDVVYLHDIefvDYDTLVDEALPAL---------- 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 150 ywgtSEWTAQQIHQAIGIC-----------DRLSLHKPVVEQPQYNMMVRDRFEWEYESVFASGYGSTIW--SPLYQGLL 216
Cdd:cd19153  141 ----RTLKDEGVIKRIGIAgypldtltratRRCSPGSLDAVLSYCHLTLQDARLESDAPGLVRGAGPHVInaSPLSMGLL 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 217 TGKynddiladgrfnnsdniyvkhfyqqilgDPEKRTKIQNQLKQLGEVA----KELGVTQAQLSLAWALKNKD-VSTAI 291
Cdd:cd19153  217 TSQ----------------------------GPPPWHPASGELRHYAAAAdavcASVEASLPDLALQYSLAAHAgVGTVL 268
                        330       340
                 ....*....|....*....|....
gi 124399033 292 TSATRPEQLEETVKSVQVVKLITK 315
Cdd:cd19153  269 LGPSSLAQLRSMLAAVDAVASLGA 292
AKR_ARA2 cd19164
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...
34-124 2.13e-15

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381390 [Multi-domain]  Cd Length: 298  Bit Score: 75.39  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  34 TKIIQKAWELGINFFDTAEIYGDgkAEIHLGHALKTL--NVQRQDIVISTKI--YGGDGNDFpnskylSRKHLIEGLRNS 109
Cdd:cd19164   37 VDIVRRALELGIRAFDTSPYYGP--SEIILGRALKALrdEFPRDTYFIITKVgrYGPDDFDY------SPEWIRASVERS 108
                         90
                 ....*....|....*
gi 124399033 110 LKRLDTPYVDIVFAH 124
Cdd:cd19164  109 LRRLHTDYLDLVYLH 123
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
40-312 2.30e-15

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 75.06  E-value: 2.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  40 AWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYggdgndfpnSKYLSRKHLIEGLRNSLKRLDTPYVD 119
Cdd:PRK11172  25 ALELGYRAIDTAQIYDN---EAAVGQAIAESGVPRDELFITTKIW---------IDNLAKDKLIPSLKESLQKLRTDYVD 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 120 IVFAH--RYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDRLSLHKPVVEQPQY--NMMVRDrfewey 195
Cdd:PRK11172  93 LTLIHwpSPNDEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAAVGAENIATNQIELSPYlqNRKVVA------ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 196 esvFASGYGSTIWSplYQGLLTGKynddiladgrfnnsdniyvkhfyqqILGDPekrtkiqnqlkQLGEVAKELGVTQAQ 275
Cdd:PRK11172 167 ---FAKEHGIHVTS--YMTLAYGK-------------------------VLKDP-----------VIARIAAKHNATPAQ 205
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 124399033 276 LSLAWALKNKdvSTAITSATRPEQLEETVKSvQVVKL 312
Cdd:PRK11172 206 VILAWAMQLG--YSVIPSSTKRENLASNLLA-QDLQL 239
AKR_FDH cd19162
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...
29-304 6.14e-15

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381388 [Multi-domain]  Cd Length: 290  Bit Score: 74.32  E-value: 6.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  29 TQDRNTKIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLnvQRQDIVISTKI-----YGGDGNDFPNSKY--LSRKH 101
Cdd:cd19162   17 GEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARH--PRAEYVVSTKVgrllePGAAGRPAGADRRfdFSADG 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 102 LIEGLRNSLKRLDTPYVDIVFAHRYD--YQTPLEETCRAFDWIIRHGLAhywgtsewtaqqihQAIGI-CDRLSLHKPVV 178
Cdd:cd19162   95 IRRSIEASLERLGLDRLDLVFLHDPDrhLLQALTDAFPALEELRAEGVV--------------GAIGVgVTDWAALLRAA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 179 EQPQYN-MMVRDRF---EWEYESVF-----ASGYGSTIWSPLYQGLLTGkyndDILADGRFNnsdniyvkhfYQQIlgdp 249
Cdd:cd19162  161 RRADVDvVMVAGRYtllDRRAATELlplcaAKGVAVVAAGVFNSGILAT----DDPAGDRYD----------YRPA---- 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124399033 250 eKRTKIQnQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETV 304
Cdd:cd19162  223 -TPEVLA-RARRLAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNL 275
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
34-319 1.05e-14

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 72.77  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  34 TKIIQKAWELGINFFDTAEIYgDGKAEIhlGHALKTLNVQRQDIVISTKIYggdgndFPNskyLSRKHLIEGLRNSLKRL 113
Cdd:cd19139   17 IDSVRTALELGYRHIDTAQIY-DNEAAV--GQAIAESGVPRDELFITTKIW------IDN---LSKDKLLPSLEESLEKL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 114 DTPYVDIVFAH---RYDyQTPLEET----CRAFDwiirHGLAHYWGTSEWTAQQIHQAIGICDRLSLHKPVVEqpqynmm 186
Cdd:cd19139   85 RTDYVDLTLIHwpsPND-EVPVEEYigalAEAKE----QGLTRHIGVSNFTIALLDEAIAVVGAGAIATNQIE------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 187 vrdrfeweyesvfasgygstiWSPLYQglltgkynDDILADgrFNNSDNIYVKHF----YQQILGDPekrtkiqnqlkQL 262
Cdd:cd19139  153 ---------------------LSPYLQ--------NRKLVA--HCKQHGIHVTSYmtlaYGKVLDDP-----------VL 190
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124399033 263 GEVAKELGVTQAQLSLAWALkNKDVStAITSATRPEQLEETVKSVQvVKLITKEVEQ 319
Cdd:cd19139  191 AAIAERHGATPAQIALAWAM-ARGYA-VIPSSTKREHLRSNLLALD-LTLDADDMAA 244
AKR_AKR9A3_9B1-4 cd19147
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ...
10-322 3.93e-12

Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381373 [Multi-domain]  Cd Length: 319  Bit Score: 66.39  E-value: 3.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVS-----AISYGN-WvnSDDKDTQDRNT--KIIQKAWELGINFFDTAEIYGDGKAEIHLGHALKTLNvQRQDIVIST 81
Cdd:cd19147    7 GIRVSplilgAMSIGDaW--SGFMGSMDKEQafELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRK-NRDQIVIAT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  82 KiYGGDGNDFPNSKYLS-------RKHLIEGLRNSLKRLDTPYVDIVFAHRYDYQTPLEETCRAFDWIIRHGLAHYWGTS 154
Cdd:cd19147   84 K-FTTDYKAYEVGKGKAvnycgnhKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 155 EWTAQQIHQAIGICDRLSLHKPVVEQPQYNMMVRDrFEWEYESVfASGYGSTIwSPlYQGLLTGKYNDDILADGRFNNSD 234
Cdd:cd19147  163 DTPAWVVSAANYYATAHGKTPFSVYQGRWNVLNRD-FERDIIPM-ARHFGMAL-AP-WDVLGGGKFQSKKAVEERKKNGE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 235 NIyvkhfyQQILGDPEKRTKIQNQLKQLGEVAKELGVTQ-AQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklI 313
Cdd:cd19147  239 GL------RSFVGGTEQTPEEVKISEALEKVAEEHGTESvTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIK--L 310

                 ....*....
gi 124399033 314 TKEVEQKIE 322
Cdd:cd19147  311 TPEEIEYLE 319
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
16-302 1.25e-11

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 63.93  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  16 ISYGNWVNSDDKDTQdrntkIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYGGD-GNDFPns 94
Cdd:cd19131   13 LGLGVWQVSNDEAAS-----AVREALEVGYRSIDTAAIYGN---EEGVGKAIRASGVPREELFITTKLWNSDqGYDST-- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  95 kylsrkhlIEGLRNSLKRLDTPYVDIVFAHrydYQTPLE----ETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDR 170
Cdd:cd19131   83 --------LRAFDESLRKLGLDYVDLYLIH---WPVPAQdkyvETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 171 lslhKPVVEQ----PQYNMMVRDRFEWEYESVFASgygstiWSPLYQGlltgkynddiladgrfnnsdniyvkhfyqQIL 246
Cdd:cd19131  152 ----VPVVNQielhPRFQQRELRAFHAKHGIQTES------WSPLGQG-----------------------------GLL 192
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 124399033 247 GDPekrtkiqnqlkQLGEVAKELGVTQAQLSLAWALKNKDVstAITSATRPEQLEE 302
Cdd:cd19131  193 SDP-----------VIGEIAEKHGKTPAQVVIRWHLQNGLV--VIPKSVTPSRIAE 235
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
10-167 3.93e-11

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 62.90  E-value: 3.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWVNSDDKDTQdrntkIIQKAWELGINFFDTAEIYGDGKAeihLGHALKTL----NVQRQDIVISTKIYg 85
Cdd:cd19111    1 GFPMPVIGLGTYQSPPEEVRA-----AVDYALFVGYRHIDTALSYQNEKA---IGEALKWWlkngKLKREEVFITTKLP- 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  86 gdgndfpnSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAH-------------RYDYQTPLEETCRAFDWIIRHGLAHYWG 152
Cdd:cd19111   72 --------PVYLEFKDTEKSLEKSLENLKLPYVDLYLIHhpcgfvnkkdkgeRELASSDVTSVWRAMEALVSEGKVKSIG 143
                        170
                 ....*....|....*
gi 124399033 153 TSEWTAQQIHQAIGI 167
Cdd:cd19111  144 LSNFNPRQINKILAY 158
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
9-180 3.98e-11

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 63.20  E-value: 3.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWvnsddKDTQDRNTKIIQKAWELGINFFDTAEIYgdgKAEIHLGHALKTL----NVQRQDIVISTKIY 84
Cdd:cd19154    8 NGVKMPLIGLGTW-----QSKGAEGITAVRTALKAGYRLIDTAFLY---QNEEAIGEALAELleegVVKREDLFITTKLW 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  85 ggdgndfpnSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAH--------RYDYQT-----------PLEETCRAFDWIIRH 145
Cdd:cd19154   80 ---------THEHAPEDVEEALRESLKKLQLEYVDLYLIHapaafkddEGESGTmengmsihdavDVEDVWRGMEKVYDE 150
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 124399033 146 GLAHYWGTSEWTAQQIHQAIGICdrlsLHKPVVEQ 180
Cdd:cd19154  151 GLTKAIGVSNFNNDQIQRILDNA----RVKPHNNQ 181
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
1-309 3.05e-09

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 57.42  E-value: 3.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   1 MEYRRLgATGLKVSAISYGNWvNSDDKDTQdrntKIIQKAWELGINFFDTAEIYGDgKAEI--HLGHALKTLNVQRQDIV 78
Cdd:cd19123    1 MKTLPL-SNGDLIPALGLGTW-KSKPGEVG----QAVKQALEAGYRHIDCAAIYGN-EAEIgaALAEVFKEGKVKREDLW 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  79 ISTKIYggdgndfpNSKYLSrKHLIEGLRNSLKRLDTPYVDIVFAH--------------RYDY----QTPLEETCRAFD 140
Cdd:cd19123   74 ITSKLW--------NNSHAP-EDVLPALEKTLADLQLDYLDLYLMHwpvalkkgvgfpesGEDLlslsPIPLEDTWRAME 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 141 WIIRHGLAHYWGTSEWTAQQIHQAIG------ICDRLSLHkPVVEQPQYNMMVRDRfeweyesvfasGYGSTIWSPLyqg 214
Cdd:cd19123  145 ELVDKGLCRHIGVSNFSVKKLEDLLAtarikpAVNQVELH-PYLQQPELLAFCRDN-----------GIHLTAYSPL--- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 215 lltgkynddiladGRfnnsdniyvkhfyqqilGDPEKRTKIQNQLKQL-----GEVAKELGVTQAQLSLAWALKNKdvST 289
Cdd:cd19123  210 -------------GS-----------------GDRPAAMKAEGEPVLLedpviNKIAEKHGASPAQVLIAWAIQRG--TV 257
                        330       340
                 ....*....|....*....|
gi 124399033 290 AITSATRPEQLEETVKSVQV 309
Cdd:cd19123  258 VIPKSVNPERIQQNLEAAEV 277
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
42-325 6.87e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 56.45  E-value: 6.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  42 ELGINFFDTAEIYGDgkAEIHLGHALKTL---NVQRQDIVISTKIYggdgnDFPNSKYLSRKHLIEGLRNSLKRLDTPYV 118
Cdd:cd19101   34 DAGLTTFDCADIYGP--AEELIGEFRKRLrreRDAADDVQIHTKWV-----PDPGELTMTRAYVEAAIDRSLKRLGVDRL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 119 DIVFAHRYDYQTP-LEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQaigICDrlSLHKPVVEQPQYNMMVRdRFEWEYES 197
Cdd:cd19101  107 DLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNFDTERLRE---ILD--AGVPIVSNQVQYSLLDR-RPENGMAA 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 198 VFAS------GYGStiwspLYQGLLTGKYNDdiLADGRFNNSDNiYVKHFYQQIL---GDPEkrtKIQNQLKQLGEVAKE 268
Cdd:cd19101  181 LCEDhgikllAYGT-----LAGGLLSEKYLG--VPEPTGPALET-RSLQKYKLMIdewGGWD---LFQELLRTLKAIADK 249
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124399033 269 LGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVklITKEVEQKIESIL 325
Cdd:cd19101  250 HGVSIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRAFSFR--LDDEDRAAIDAVL 304
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
35-302 8.74e-09

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 55.72  E-value: 8.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  35 KIIQKAWELGINFFDTAEIYgdgKAEIHLGHALKTL----NVQRQDIVISTKIyggdgndfpNSKYLSRKHLIEGLRNSL 110
Cdd:cd19136   19 QAVDAALKAGYRLIDTASVY---RNEADIGKALRDLlpkyGLSREDIFITSKL---------APKDQGYEKARAACLGSL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 111 KRLDTPYVDIVFAH-----RYDYQTPLEETCRAFDW-----IIRHGLAHYWGTSEWTAQQIHQAIGICDRlslhKPVVEQ 180
Cdd:cd19136   87 ERLGTDYLDLYLIHwpgvqGLKPSDPRNAELRRESWraledLYKEGKLRAIGVSNYTVRHLEELLKYCEV----PPAVNQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 181 ----PQYNMmvRDRFEW-EYESVFASGYgstiwSPLYQGLLTgkynddiladgrfnnsdniyvkhfyqqILGDPEkrtki 255
Cdd:cd19136  163 vefhPHLVQ--KELLKFcKDHGIHLQAY-----SSLGSGDLR---------------------------LLEDPT----- 203
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 124399033 256 qnqlkqLGEVAKELGVTQAQLSLAWALKNkDVStAITSATRPEQLEE 302
Cdd:cd19136  204 ------VLAIAKKYGRTPAQVLLRWALQQ-GIG-VIPKSTNPERIAE 242
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
10-283 1.14e-08

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 55.35  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWVNSDDKdtqdrNTKIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYGGDGn 89
Cdd:cd19132    4 GTQIPAIGFGTYPLKGDE-----GVEAVVAALQAGYRLLDTAFNYEN---EGAVGEAVRRSGVPREELFVTTKLPGRHH- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  90 dfpnskylSRKHLIEGLRNSLKRLDTPYVDIVFAH-------RYdyqtplEETCRAFDWIIRHGLAHYWGTSEWTAQQIh 162
Cdd:cd19132   75 --------GYEEALRTIEESLYRLGLDYVDLYLIHwpnpsrdLY------VEAWQALIEAREEGLVRSIGVSNFLPEHL- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 163 qaigicDRLSLH---KPVVEQ----PQYNMMVRDRFEWEYESVFASgygstiWSPLYQGlltgkynddiladgrfnnsdn 235
Cdd:cd19132  140 ------DRLIDEtgvTPAVNQielhPYFPQAEQRAYHREHGIVTQS------WSPLGRG--------------------- 186
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 124399033 236 iyvkhfyQQILGDPekrtkiqnqlkQLGEVAKELGVTQAQLSLAWALK 283
Cdd:cd19132  187 -------SGLLDEP-----------VIKAIAEKHGKTPAQVVLRWHVQ 216
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
10-180 1.71e-08

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 54.98  E-value: 1.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWVNSDDKDTqdrnTKIIQKAWELGINFFDTAEIYGDgKAEIhlGHALKTL----NVQRQDIVISTKIYG 85
Cdd:cd19116    8 GNEIPAIALGTWKLKDDEGV----RQAVKHAIEAGYRHIDTAYLYGN-EAEV--GEAIREKiaegVVKREDLFITTKLWN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  86 gdgndfpnsKYLSRKHLIEGLRNSLKRLDTPYVDIVFAH-------RYDYQTPLE---------ETCRAFDWIIRHGLAH 149
Cdd:cd19116   81 ---------SYHEREQVEPALRESLKRLGLDYVDLYLIHwpvafkeNNDSESNGDgslsdidylETWRGMEDLVKLGLTR 151
                        170       180       190
                 ....*....|....*....|....*....|.
gi 124399033 150 YWGTSEWTAQQIHQAIgicdRLSLHKPVVEQ 180
Cdd:cd19116  152 SIGVSNFNSEQINRLL----SNCNIKPAVNQ 178
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
9-180 4.11e-08

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 53.93  E-value: 4.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWvnsDDKDTQDRNTkiIQKAWELGINFFDTAEIYGDgkaEIHLGHALK-----TLNVQRQDIVISTKI 83
Cdd:cd19106    3 TGQKMPLIGLGTW---KSKPGQVKAA--VKYALDAGYRHIDCAAVYGN---EQEVGEALKekvgpGKAVPREDLFVTSKL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  84 YggdgndfpNSKYlsRKHLIEG-LRNSLKRLDTPYVDIVFAH--------------------RYDYqTPLEETCRAFDWI 142
Cdd:cd19106   75 W--------NTKH--HPEDVEPaLRKTLKDLQLDYLDLYLIHwpyafergdnpfpknpdgtiRYDS-THYKETWKAMEKL 143
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 124399033 143 IRHGLAHYWGTSEWTAQQIHQAIGICDrlslHKPVVEQ 180
Cdd:cd19106  144 VDKGLVKAIGLSNFNSRQIDDILSVAR----IKPAVLQ 177
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
16-318 4.94e-08

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 53.68  E-value: 4.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  16 ISYGNWVNSDDKDTQDrntkiIQKAWELGINFFDTAEIYGD----GKAeihLGHALKTLNVQRQDIVISTKIYggdgndf 91
Cdd:cd19128    4 LGFGTYKITESESKEA-----VKNAIKAGYRHIDCAYYYGNeafiGIA---FSEIFKDGGVKREDLFITSKLW------- 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  92 pnsKYLSRKHLI-EGLRNSLKRLDTPYVDIVFAH-------------------RYDYQTPLEETCRAFDWIIRHGLAHYW 151
Cdd:cd19128   69 ---PTMHQPENVkEQLLITLQDLQLEYLDLFLIHwplafdmdtdgdprddnqiQSLSKKPLEDTWRAMEQCVDEKLTKNI 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 152 GTSEWTAQQIHQAIGICDRlslhKPVVEQpqynmmvrdrfeweYESvfasgygstiwSPLYQglltgkyNDDILadgRFN 231
Cdd:cd19128  146 GVSNYSTKLLTDLLNYCKI----KPFMNQ--------------IEC-----------HPYFQ-------NDKLI---KFC 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 232 NSDNIYVKHfYQQILGDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALK--NKDVSTAITSATrPEQLEETVKSVQv 309
Cdd:cd19128  187 IENNIHVTA-YRPLGGSYGDGNLTFLNDSELKALATKYNTTPPQVIIAWHLQkwPKNYSVIPKSAN-KSRCQQNFDIND- 263

                 ....*....
gi 124399033 310 VKLITKEVE 318
Cdd:cd19128  264 LALTKEDMD 272
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
9-324 6.44e-08

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 53.12  E-value: 6.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWvNSDDKDTQDRntkiIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTL----NVQRQDIVISTKIY 84
Cdd:cd19125    7 TGAKIPAVGLGTW-QADPGVVGNA----VKTAIKEGYRHIDCAAIYGN---EKEIGKALKKLfedgVVKREDLFITSKLW 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  85 ggdgndfpnSKYLSRKHLIEGLRNSLKRLDTPYVDIVFAH-------------RYDY-QTPLEETCRAFDWIIRHGLAHY 150
Cdd:cd19125   79 ---------CTDHAPEDVPPALEKTLKDLQLDYLDLYLIHwpvrlkkgahmpePEEVlPPDIPSTWKAMEKLVDSGKVRA 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 151 WGTSEWTAQQIHQAIGICDRlslhKPVVEQ-------PQYNMmvrdrfeWEY---ESVFASGYgstiwSPlyqglltgky 220
Cdd:cd19125  150 IGVSNFSVKKLEDLLAVARV----PPAVNQvechpgwQQDKL-------HEFcksKGIHLSAY-----SP---------- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 221 nddiladgrfnnsdniyvkhfyqqiLGDPEKRTKIQNQLKQ--LGEVAKELGVTQAQLSLAWALKNKdvSTAITSATRPE 298
Cdd:cd19125  204 -------------------------LGSPGTTWVKKNVLKDpiVTKVAEKLGKTPAQVALRWGLQRG--TSVLPKSTNEE 256
                        330       340
                 ....*....|....*....|....*..
gi 124399033 299 QLEEtvkSVQVVKL-ITKEVEQKIESI 324
Cdd:cd19125  257 RIKE---NIDVFDWsIPEEDFAKFSSI 280
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
42-302 7.27e-08

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 52.71  E-value: 7.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  42 ELGINFFDTAEIYGdgkAEIHLGHALKTLNVQRQDIVISTKIYGGDgndfpnskYLSRKhLIEGLRNSLKRLDTPYVDIV 121
Cdd:cd19135   37 ECGYRHIDTAKRYG---CEELLGKAIKESGVPREDLFLTTKLWPSD--------YGYES-TKQAFEASLKRLGVDYLDLY 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 122 FAHRYDYQTP-------LEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDRLslhkPVVEQPQYNMMVRDRFEWE 194
Cdd:cd19135  105 LLHWPDCPSSgknvketRAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVV----PHVNQVEFHPFQNPVELIE 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 195 Y---ESVFASGYgstiwSPLYQGlltgkynddiladgrfnnsdniyvkhfyqQILGDPekrtKIQnqlkqlgEVAKELGV 271
Cdd:cd19135  181 YcrdNNIVFEGY-----CPLAKG-----------------------------KALEEP----TVT-------ELAKKYQK 215
                        250       260       270
                 ....*....|....*....|....*....|.
gi 124399033 272 TQAQLSLAWALKNkDVSTaITSATRPEQLEE 302
Cdd:cd19135  216 TPAQILIRWSIQN-GVVT-IPKSTKEERIKE 244
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
9-124 9.95e-08

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 52.50  E-value: 9.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWVNSDDKdtqdrNTKIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYggdg 88
Cdd:cd19117   10 TGAEIPAVGLGTWQSKPNE-----VAKAVEAALKAGYRHIDTAAIYGN---EEEVGQGIKDSGVPREEIFITTKLW---- 77
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 124399033  89 NDFpnskylsRKHLIEGLRNSLKRLDTPYVDIVFAH 124
Cdd:cd19117   78 CTW-------HRRVEEALDQSLKKLGLDYVDLYLMH 106
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
9-324 1.46e-07

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 52.49  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWvnsddKDTQDRNTKIIQKAWELGINFFDTAEIYGD----GKAeihLGHALKTLNVQRQDIVISTKIY 84
Cdd:cd19112    7 SGHKMPVIGLGVW-----RMEPGEIKELILNAIKIGYRHFDCAADYKNekevGEA---LAEAFKTGLVKREDLFITTKLW 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  85 GGDgndfpnskylsRKHLIEGLRNSLKRLDTPYVDIVFAH-----------------------RYDYQTPLEETCRAFDW 141
Cdd:cd19112   79 NSD-----------HGHVIEACKDSLKKLQLDYLDLYLVHfpvatkhtgvgttgsalgedgvlDIDVTISLETTWHAMEK 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 142 IIRHGLAHYWGTSEWTAQQIHQaigiCDRLSLHKPVVEQpqynMMVRDRFEWEYESVFASGYG--STIWSPLYQGLLtgk 219
Cdd:cd19112  148 LVSAGLVRSIGISNYDIFLTRD----CLAYSKIKPAVNQ----IETHPYFQRDSLVKFCQKHGisVTAHTPLGGAAA--- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 220 yNDDiladgRFNnsdniyvkhfYQQILGDPekrtkiqnqlkQLGEVAKELGVTQAQLSLAWALKNKDVstAITSATRPEQ 299
Cdd:cd19112  217 -NAE-----WFG----------SVSPLDDP-----------VLKDLAKKYGKSAAQIVLRWGIQRNTA--VIPKSSKPER 267
                        330       340
                 ....*....|....*....|....*
gi 124399033 300 LEETVKsVQVVKLiTKEVEQKIESI 324
Cdd:cd19112  268 LKENID-VFDFQL-SKEDMKLIKSL 290
PRK10376 PRK10376
putative oxidoreductase; Provisional
36-283 1.53e-07

putative oxidoreductase; Provisional


Pssm-ID: 236676 [Multi-domain]  Cd Length: 290  Bit Score: 52.28  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  36 IIQKAWELGINFFDTAEIYGDgkaeiHLGHAL--KTLNVQRQDIVISTKI---YGGDGNDFPNskyLSRKHLIEGLRNSL 110
Cdd:PRK10376  45 VLREAVALGVNHIDTSDFYGP-----HVTNQLirEALHPYPDDLTIVTKVgarRGEDGSWLPA---FSPAELRRAVHDNL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 111 KRLDTPYVDIV-FAHRYDYQTP----LEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDrlslhkPVVEQPQYNM 185
Cdd:PRK10376 117 RNLGLDVLDVVnLRLMGDGHGPaegsIEEPLTVLAELQRQGLVRHIGLSNVTPTQVAEARKIAE------IVCVQNHYNL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 186 MVRDrfeweyesvfasgygstiwsplyqglltgkynDDILADGRfnNSDNI-YVKHFyqqILGDpekRTKIQNQlkQLGE 264
Cdd:PRK10376 191 AHRA--------------------------------DDALIDAL--ARDGIaYVPFF---PLGG---FTPLQSS--TLSD 228
                        250
                 ....*....|....*....
gi 124399033 265 VAKELGVTQAQLSLAWALK 283
Cdd:PRK10376 229 VAASLGATPMQVALAWLLQ 247
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
19-124 1.54e-07

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 52.00  E-value: 1.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  19 GNWVNSDDKdtqdrNTKIIQKAWELGINFFDTAEIYgdgKAEIHLGHALKTLNVQRQDIVISTKIYGGDgndfpnskyls 98
Cdd:PRK11565  21 GVWQASNEE-----VITAIHKALEVGYRSIDTAAIY---KNEEGVGKALKEASVAREELFITTKLWNDD----------- 81
                         90       100
                 ....*....|....*....|....*.
gi 124399033  99 RKHLIEGLRNSLKRLDTPYVDIVFAH 124
Cdd:PRK11565  82 HKRPREALEESLKKLQLDYVDLYLMH 107
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
10-302 2.81e-07

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 51.06  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWvNSDDKDTQdrntKIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYGGD-G 88
Cdd:cd19130    7 GNSIPQLGYGVF-KVPPADTQ----RAVATALEVGYRHIDTAAIYGN---EEGVGAAIAASGIPRDELFVTTKLWNDRhD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  89 NDFPNSKYlsrkhlieglRNSLKRLDTPYVDIVFAHrydYQTPLE----ETCRAFDWIIRHGLAHYWGTSEWTAQQIHQA 164
Cdd:cd19130   79 GDEPAAAF----------AESLAKLGLDQVDLYLVH---WPTPAAgnyvHTWEAMIELRAAGRTRSIGVSNFLPPHLERI 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 165 IGICDRLslhkPVVEQPQYNMMVRDRFEWEYESvfASGYGSTIWSPLYQGlltgkynddiladgrfnnsdniyvkhfyqQ 244
Cdd:cd19130  146 VAATGVV----PAVNQIELHPAYQQRTIRDWAQ--AHDVKIEAWSPLGQG-----------------------------K 190
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124399033 245 ILGDPekrtkiqnqlkQLGEVAKELGVTQAQLSLAWALKNKdvSTAITSATRPEQLEE 302
Cdd:cd19130  191 LLGDP-----------PVGAIAAAHGKTPAQIVLRWHLQKG--HVVFPKSVRRERMED 235
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
10-302 3.82e-07

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 50.65  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWVNSDDKDTQdrntKIIQKAWELGINFFDTAEIYGDGKAeihLGHALKTLNVQRQDIVISTKIYggdgn 89
Cdd:cd19133    6 GVEMPILGFGVFQIPDPEECE----RAVLEAIKAGYRLIDTAAAYGNEEA---VGRAIKKSGIPREELFITTKLW----- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  90 dFPNSKYLSRKHLIEGlrnSLKRLDTPYVDIVFAHR--YDYqtplEETCRAFDWIIRHGLAHYWGTSEWTAQQIhqaigi 167
Cdd:cd19133   74 -IQDAGYEKAKKAFER---SLKRLGLDYLDLYLIHQpfGDV----YGAWRAMEELYKEGKIRAIGVSNFYPDRL------ 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 168 cDRLSLH---KPVVEQPQYNMmvrdrFEWEYESV-FASGYGSTI--WSPlyqglltgkynddiLADGRFNnsdniyvkhf 241
Cdd:cd19133  140 -VDLILHnevKPAVNQIETHP-----FNQQIEAVeFLKKYGVQIeaWGP--------------FAEGRNN---------- 189
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124399033 242 yqqILGDPEkrtkiqnqlkqLGEVAKELGVTQAQLSLAWALKnKDVSTaITSATRPEQLEE 302
Cdd:cd19133  190 ---LFENPV-----------LTEIAEKYGKSVAQVILRWLIQ-RGIVV-IPKSVRPERIAE 234
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
15-300 6.25e-07

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 50.24  E-value: 6.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  15 AISYGNWVNSDDKDTQDrntkiIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYGGDgNDFPNS 94
Cdd:cd19134   13 VIGLGVGELSDDEAERS-----VSAALEAGYRLIDTAAAYGN---EAAVGRAIAASGIPRGELFVTTKLATPD-QGFTAS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  95 kylsrkhlIEGLRNSLKRLDTPYVDIVFAHrydYQTPLE----ETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGicdr 170
Cdd:cd19134   84 --------QAACRASLERLGLDYVDLYLIH---WPAGREgkyvDSWGGLMKLREEGLARSIGVSNFTAEHLENLID---- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 171 LSLHKPVVEQ----PQYNMMVRDRFEWEYESVFASgygstiWSPLYQGlltgkynddiladgrfnnsdniyvkhfyqQIL 246
Cdd:cd19134  149 LTFFTPAVNQielhPLLNQAELRKVNAQHGIVTQA------YSPLGVG-----------------------------RLL 193
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 124399033 247 GDPEkrtkiqnqlkqLGEVAKELGVTQAQLSLAWALKNKDVstAITSATRPEQL 300
Cdd:cd19134  194 DNPA-----------VTAIAAAHGRTPAQVLLRWSLQLGNV--VISRSSNPERI 234
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
9-124 8.70e-07

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 49.72  E-value: 8.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWVNSDDKDTQDrntkiIQKAWELGINFFDTAEIYGDgKAEIhlGHALKTL-----NVQRQDIVISTKI 83
Cdd:cd19118    3 TGNKIPAIGLGTWQAEPGEVGAA-----VKIALKAGYRHLDLAKVYQN-QHEV--GQALKELlkeepGVKREDLFITSKL 74
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 124399033  84 YggdgndfpNSKYlSRKHLIEGLRNSLKRLDTPYVDIVFAH 124
Cdd:cd19118   75 W--------NNSH-RPEYVEPALDDTLKELGLDYLDLYLIH 106
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
9-309 1.59e-06

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 49.16  E-value: 1.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWVNSDDKDtqdRNTKIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTL-----NVQRQDIVISTKI 83
Cdd:cd19122    5 NGVKIPAVGFGTFANEGAKG---ETYAAVTKALDVGYRHLDCAWFYLN---EDEVGDAVRDFlkenpSVKREDLFICTKV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  84 YggdgndfpnsKYLSR-KHLIEGLRNSLKRLDTPYVDIVFAH------RYDYQTPL-----------------EETCRAF 139
Cdd:cd19122   79 W----------NHLHEpEDVKWSIDNSLKNLKLDYIDLFLVHwpiaaeKNDQRSPKlgpdgkyvilkdltenpEPTWRAM 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 140 DWIIRHGLAHYWGTSEWTAQQIHQAIGICDRlslhKPVVEQPQYNMMVRDRFEWEYesVFASGYGSTIWSPLyqglltGK 219
Cdd:cd19122  149 EEIYESGKAKAIGVSNWTIPGLKKLLSFAKV----KPHVNQIEIHPFLPNEELVDY--CFSNDILPEAYSPL------GS 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 220 YNddiladgrfnnsdniyvkhfyqQILGDPEKrtkiQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVstAITSATRPEQ 299
Cdd:cd19122  217 QN----------------------QVPSTGER----VSENPTLNEVAEKGGYSLAQVLIAWGLRRGYV--VLPKSSTPSR 268
                        330
                 ....*....|
gi 124399033 300 LEETVKSVQV 309
Cdd:cd19122  269 IESNFKSIEL 278
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
31-216 2.94e-06

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 47.82  E-value: 2.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  31 DRNTKIIQKAWELGINFFDTAEIYgdgKAEIHLGHALKTLNVQRQDIVISTKIYGGDGNDfpnskylsrKHLIEGLRNSL 110
Cdd:cd19126   23 DETERAVQTALENGYRSIDTAAIY---KNEEGVGEAIRESGVPREELFVTTKLWNDDQRA---------RRTEDAFQESL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 111 KRLDTPYVDIVFAHrYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGICDRlslhKPVVEQPQYNMMVRDR 190
Cdd:cd19126   91 DRLGLDYVDLYLIH-WPGKDKFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHADV----VPAVNQVEFHPYLTQK 165
                        170       180
                 ....*....|....*....|....*.
gi 124399033 191 FEWEYesVFASGYGSTIWSPLYQGLL 216
Cdd:cd19126  166 ELRGY--CKSKGIVVEAWSPLGQGGL 189
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
9-211 3.52e-06

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 48.03  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWVNSDDKDtqdRNTKIIQKAWELGINFFDTAEIYGdgkAEIHLGHALKT-----LNVQRQDIVISTKI 83
Cdd:cd19124    1 SGQTMPVIGMGTASDPPSPE---DIKAAVLEAIEVGYRHFDTAAAYG---TEEALGEALAEalrlgLVKSRDELFVTSKL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  84 YGGDgndfpnskyLSRKHLIEGLRNSLKRLDTPYVDIVFAH--------RYDYQTP--------LEETCRAFDWIIRHGL 147
Cdd:cd19124   75 WCSD---------AHPDLVLPALKKSLRNLQLEYVDLYLIHwpvslkpgKFSFPIEeedflpfdIKGVWEAMEECQRLGL 145
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124399033 148 AHYWGTSEWTAQQIHqaigicDRLSLHK--PVVEQPQYNMMVRDRFEWEYESvfASGYGSTIWSPL 211
Cdd:cd19124  146 TKAIGVSNFSCKKLQ------ELLSFATipPAVNQVEMNPAWQQKKLREFCK--ANGIHVTAYSPL 203
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
8-302 4.51e-06

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 47.51  E-value: 4.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   8 ATGLKVSAISYGNWVNSDDKDTqdrnTKIIQKAWELGINFFDTAEIYgdgKAEIHLGHALKTLNVQRQDIVISTKIYGGD 87
Cdd:cd19156    4 ANGVEMPRLGLGVWRVQDGAEA----ENAVKWAIEAGYRHIDTAAIY---KNEEGVGQGIRESGVPREEVFVTTKLWNSD 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  88 gndfpnSKYLSRkhlIEGLRNSLKRLDTPYVDIVFAHrYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWTAQQIHQAIGI 167
Cdd:cd19156   77 ------QGYEST---LAAFEESLEKLGLDYVDLYLIH-WPVKGKFKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKS 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 168 CDRlslhKPVVEQ----PQYNMMVRDRFEWEYESVFasgygsTIWSPLYQGlltgkynddiladgrfnnsdniyvkhfyq 243
Cdd:cd19156  147 CKV----APMVNQielhPLLTQEPLRKFCKEKNIAV------EAWSPLGQG----------------------------- 187
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124399033 244 QILGDPEkrtkiqnqlkqLGEVAKELGVTQAQLSLAWALKNKDVStaITSATRPEQLEE 302
Cdd:cd19156  188 KLLSNPV-----------LKAIGKKYGKSAAQVIIRWDIQHGIIT--IPKSVHEERIQE 233
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
9-167 5.10e-06

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 47.49  E-value: 5.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWvNSDDKDTQDRNTkiIQKAWELGINFFDTAEIYGdgkAEIHLGHALKTL----NVQRQDIVISTKIY 84
Cdd:cd19119    8 TGASIPALGLGTA-SPHEDRAEVKEA--VEAAIKEGYRHIDTAYAYE---TEDFVGEAIKRAiddgSIKREELFITTKVW 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  85 ggdgndfPnskyLSRKHLIEGLRNSLKRLDTPYVDIVFAHrydYQTPL----EETCRAFDWIIRHGLAHYWGTSEW--TA 158
Cdd:cd19119   82 -------P----TFYDEVERSLDESLKALGLDYVDLLLVH---WPVCFekdsDDSGKPFTPVNDDGKTRYAASGDHitTY 147
                        170
                 ....*....|....*..
gi 124399033 159 QQIHQ--------AIGI 167
Cdd:cd19119  148 KQLEKiyldgrakAIGV 164
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
8-302 7.05e-06

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 47.00  E-value: 7.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   8 ATGLKVSAISYGNWVNSDDKDTQDrntkIIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYGGD 87
Cdd:cd19157    5 NNGVKMPWLGLGVFKVEEGSEVVN----AVKTALKNGYRSIDTAAIYGN---EEGVGKGIKESGIPREELFITSKVWNAD 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  88 gndfpnskyLSRKHLIEGLRNSLKRLDTPYVDIVFAHrYDYQTPLEETCRAFDWIIRHGLAHYWGTSEWtaqQIHQAIGI 167
Cdd:cd19157   78 ---------QGYDSTLKAFEASLERLGLDYLDLYLIH-WPVKGKYKETWKALEKLYKDGRVRAIGVSNF---QVHHLEDL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 168 CDRLSLhKPVVEQPQYNmmvrDRFEWEYESVFASGYGSTI--WSPLYQGlltgkynddiladgrfnnsdniyvkhfyqQI 245
Cdd:cd19157  145 LADAEI-VPMVNQVEFH----PRLTQKELRDYCKKQGIQLeaWSPLMQG-----------------------------QL 190
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 124399033 246 LGDPekrtkiqnqlkQLGEVAKELGVTQAQLSLAWALKNkDVSTaITSATRPEQLEE 302
Cdd:cd19157  191 LDNP-----------VLKEIAEKYNKSVAQVILRWDLQN-GVVT-IPKSIKEHRIIE 234
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
10-168 2.32e-05

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 45.59  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWVNSDDKDTqdrntKIIQKAWELGINFFDTAEIYGDGKAeihLGHALKTL----NVQRQDIVISTKIYG 85
Cdd:cd19155    9 GEKMPVVGLGTWQSSPEEIE-----TAVDTALEAGYRHIDTAYVYRNEAA---IGNVLKKWidsgKVKREELFIVTKLPP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  86 GdGNdfpnskylsRKHLIEG-LRNSLKRLDTPYVDIVFAH---------------------RYDYQTPLEETCRAFDWII 143
Cdd:cd19155   81 G-GN---------RREKVEKfLLKSLEKLQLDYVDLYLIHfpvgslskeddsgkldptgehKQDYTTDLLDIWKAMEAQV 150
                        170       180
                 ....*....|....*....|....*
gi 124399033 144 RHGLAHYWGTSEWTAQQIHQAIGIC 168
Cdd:cd19155  151 DQGLTRSIGLSNFNREQMARILKNA 175
AKR_unchar cd19098
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
24-311 3.47e-05

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381324 [Multi-domain]  Cd Length: 318  Bit Score: 45.03  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  24 SDDKDT---QDRNTKIIQKAWELGINFFDTAEIYGdgKAEIHLGHALKTLNVQRQDIVISTK---IYGGDGN---DFPNS 94
Cdd:cd19098   25 GSGRSVeamRAHTHAVLDAAWAAGVRYFDAARSYG--RAEEFLGSWLRSRNIAPDAVFVGSKwgyTYTADWQvdaAVHEV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  95 KYLSRKHLIEGLRNSLKRLDtPYVDIVFAHRYDYQTP-LEET--------CRAFDWIIrhGLAhYWGTSEwtAQQIHQAI 165
Cdd:cd19098  103 KDHSLARLLKQWEETRSLLG-KHLDLYQIHSATLESGvLEDAdvlaalaeLKAEGVKI--GLS-LSGPQQ--AETLRRAL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 166 GIcdRLSLHKP--VVeQPQYNMMVRDRFEwEYESVFASGYGSTIwsplyqglltgkynDDILADGRfnnsdniyvkhfyq 243
Cdd:cd19098  177 EI--EIDGARLfdSV-QATWNLLEQSAGE-ALEEAHEAGMGVIV--------------KEALANGR-------------- 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124399033 244 qiLGDPEKRTKIQNQLKQLGEVAKELGVTQAQLSLAWALKNKDVSTAITSATRPEQLEETVKSVQVVK 311
Cdd:cd19098  225 --LTDRNPSPELAPLMAVLKAVADRLGVTPDALALAAVLAQPFVDVVLSGAATPEQLRSNLRALDVSL 290
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
9-141 4.43e-05

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 44.44  E-value: 4.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWvNSDDKDTQdrntKIIQKAWELGINFFDTAEIYGDgkaEIHLGHALK---TLNVQRQDIVISTKIYg 85
Cdd:cd19121    8 TGASIPAVGLGTW-QAKAGEVK----AAVAHALKIGYRHIDGALCYQN---EDEVGEGIKeaiAGGVKREDLFVTTKLW- 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124399033  86 gdgndfpnSKYLSRkhLIEGLRNSLKRLDTPYVDIVFAH---------RYDYQTPLEETCRAFDW 141
Cdd:cd19121   79 --------STYHRR--VELCLDRSLKSLGLDYVDLYLVHwpvllnpngNHDLFPTLPDGSRDLDW 133
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
9-180 5.91e-05

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 44.36  E-value: 5.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033   9 TGLKVSAISYGNWvnsddKDTQDRNTKIIQKAWELGINFFDTAEIYGDGKaEIHLG--HALKTLNVQRQDIVISTKIYgg 86
Cdd:cd19113    7 SGYKMPSVGFGCW-----KLDNATAADQIYQAIKAGYRLFDGAEDYGNEK-EVGEGvnRAIDEGLVKREELFLTSKLW-- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  87 dgNDFPNSKYLSRkhlieGLRNSLKRLDTPYVDIVFAH------------------------RYDY-QTPLEETCRAFDW 141
Cdd:cd19113   79 --NNFHDPKNVET-----ALNKTLSDLKLDYVDLFLIHfpiafkfvpieekyppgfycgdgdNFVYeDVPILDTWKALEK 151
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 124399033 142 IIRHGLAHYWGTSEWTAQQIHQAIgicdRLSLHKPVVEQ 180
Cdd:cd19113  152 LVDAGKIKSIGVSNFPGALILDLL----RGATIKPAVLQ 186
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
10-302 4.45e-04

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 41.24  E-value: 4.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWVNSDDKDTQDrntkiIQKAWELGINFFDTAEIYGDgkaEIHLGHALKTLNVQRQDIVISTKIYGGD-G 88
Cdd:cd19127    6 GVEMPALGLGVFQTPPEETADA-----VATALADGYRLIDTAAAYGN---EREVGEGIRRSGVDRSDIFVTTKLWISDyG 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  89 NDfpnskylsrkHLIEGLRNSLKRLDTPYVDIVFAHrydYQTPLE-----ETCRAFDWIIRHGLAHYWGTSEWTAQQIHQ 163
Cdd:cd19127   78 YD----------KALRGFDASLRRLGLDYVDLYLLH---WPVPNDfdrtiQAYKALEKLLAEGRVRAIGVSNFTPEHLER 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033 164 AIGICD------RLSLHkPVVEQPQynMMVRDRfeweyesvfASGYGSTIWSPLyqglltgkynDDILADGRFNNSDNIY 237
Cdd:cd19127  145 LIDATTvvpavnQVELH-PYFSQKD--LRAFHR---------RLGIVTQAWSPI----------GGVMRYGASGPTGPGD 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124399033 238 VkhfyqqiLGDPekrtkiqnqlkQLGEVAKELGVTQAQLSLAWALKNkDVStAITSATRPEQLEE 302
Cdd:cd19127  203 V-------LQDP-----------TITGLAEKYGKTPAQIVLRWHLQN-GVS-AIPKSVHPERIAE 247
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
10-180 6.64e-04

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 40.90  E-value: 6.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  10 GLKVSAISYGNWVnSDDKDTQDrntkIIQKAWELGINFFDTAEIYgdgKAEIHLGHALKTL----NVQRQDIVISTKIYg 85
Cdd:cd19129    3 SGAIPALGFGTLI-PDPSATRN----AVKAALEAGFRHFDCAERY---RNEAEVGEAMQEVfkagKIRREDLFVTTKLW- 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124399033  86 gdgndfpNSKYlsRKHLIE-GLRNSLKRLDTPYVDIVFAHR--------------------YDYQTPLEETCRAFDWIIR 144
Cdd:cd19129   74 -------NTNH--RPERVKpAFEASLKRLQLDYLDLYLIHTpfafqpgdeqdprdangnviYDDGVTLLDTWRAMERLVD 144
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 124399033 145 HGLAHYWGTSEWTAQQIhQAIGICDRLslhKPVVEQ 180
Cdd:cd19129  145 EGRCKAIGLSDVSLEKL-REIFEAARI---KPAVVQ 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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