|
Name |
Accession |
Description |
Interval |
E-value |
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
432-732 |
1.56e-132 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 393.48 E-value: 1.56e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 432 SLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDKYLVPEGKGYS 511
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 512 LYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYaTRAWPGGCGDKKLGANYAPCVLPQLQAASR 591
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGEKGVSALVSSF-RRAAPGGPGAAKAGGNYAASLLAQKEAAEK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 592 GYQQNLWLFGPNNNITEVGTMNAFFVFKDsktgkkELVTAPLDGTILEGVTRDSILNLAKERlepsEWTISERYFTIGEV 671
Cdd:cd01557 160 GYDQALWLDGAHGYVAEVGTMNIFFVKDG------ELITPPLDGSILPGITRDSILELARDL----GIKVEERPITRDEL 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2360683871 672 TerskngELLEAFGSGTAAIVSPIKEIGWKGEQInipllPGEQTGPLAKEVAQWINGIQYG 732
Cdd:cd01557 230 Y------EADEVFATGTAAVVTPVGEIDYRGKEP-----GEGEVGPVTKKLYDLLTDIQYG 279
|
|
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
381-743 |
5.49e-128 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 384.88 E-value: 5.49e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 381 KVKITTTQHASKPKPNSELVFGKSFTDHMLTVEWTAEKgWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKI 460
Cdd:PRK13357 4 TLKPNPTSDEKRAIDWANLGFGYVFTDHMVVIDYKDGK-WHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 461 TMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDK-YLVPEGKGYSLYIRPTLIGTTAGLGVSTPDRALLYVIC 539
Cdd:PRK13357 83 VLFRPDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRdWVPPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 540 CPVGPYYKTGFKAVR-LEATDYaTRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFGPNN-NITEVGTMNAFFV 617
Cdd:PRK13357 163 SPVGAYFKGGVKPVSiWVSDEY-DRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHtYIEEVGGMNFFFI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 618 FKDsktgkkELVTAPLDGTILEGVTRDSILNLAKerlepsEW--TISERYFTIGEVTERSKNGELLEAFGSGTAAIVSPI 695
Cdd:PRK13357 242 TKD------GTVTPPLSGSILPGITRDSLLQLAE------DLglTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPI 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2360683871 696 KEIGWKGEQINIpllPGEQTGPLAKEVAQWINGIQYGETE--HGnWSRVV 743
Cdd:PRK13357 310 GGIKYKDKEFVI---GDGEVGPVTQKLYDELTGIQFGDVEdpHG-WIVKV 355
|
|
| HSF1 |
COG5169 |
Heat shock transcription factor [Transcription]; |
1-279 |
9.43e-104 |
|
Heat shock transcription factor [Transcription];
Pssm-ID: 227497 [Multi-domain] Cd Length: 282 Bit Score: 319.38 E-value: 9.43e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 1 MDATSRMEQPDVFVSKLYHLLQGNAYSNIIQWSTDGSKFVIWNPDQFTKVILERFFGIHTFAAFVKQLSKYNFQKAE-RP 79
Cdd:COG5169 1 MSMSSRWSQPKEFVHKLYQILEEPEYYKLIQWSPDGRSFVILDPEEFTKVILPRYFKHGNFASFVRQLNKYGFHKVShKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 80 DCVEFSN---IHFQKDN-INSLS--LVKAHQSAATPNVAAINNMNKQCTFHwdPFKVNSILSKAIGKPSFEKLVKNVDRL 153
Cdd:COG5169 81 GQRSYYNenvWEFGNKNfQLGMIelLKKIKRKKAPSNRVDSNNESKDAMMN--IEVENIILPQSELYNSLSSLSNVNQTL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 154 QGNLDELKSTNADSLRIIREINASLQTISYHQFHAYQTANFLQENFDAIKKVVCPDSCLQHQQRQPKRPKRYSLLLLIPN 233
Cdd:COG5169 159 LLYLNELKEYNYRNLRTIDDINAMLADLSMSPFADEHLKSFLQELFGAYKEVAEPQSPTQHQRGEPGQRFHNSVVPLADS 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2360683871 234 ASELSETPLMRFAGVFEfmNCSLDTATQWYPQLHLEAYDLLFVTVS 279
Cdd:COG5169 239 KNEVDQKGDGKVANLQN--NLSLDTATNSDSHLTIDALSAAFSTVS 282
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
420-735 |
2.90e-92 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 290.51 E-value: 2.90e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 420 WGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQ 499
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 500 DK-YLVPEGKGYSLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYATRAWPGGCGDKKLGANY 578
Cdd:TIGR01123 81 NKdWVPPYGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGLAPVSIFVTTEYDRAAPGGTGAVKVGGNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 579 APCVLPQLQAASRGYQQNLWLfGPNNN--ITEVGTMNAFFVFKDSktgkkELVTAPLDGTILEGVTRDSILNLAKERlep 656
Cdd:TIGR01123 161 AASLLAQAKAAEQGCDQVVYL-DPVEHtyIEEVGAMNFFFITGDG-----ELVTPPLSGSILPGITRDSLLQLAKDL--- 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2360683871 657 sEWTISERYFTIGEVTERSKNGEllEAFGSGTAAIVSPIKEIGWKGEQINIpllPGEQTGPLAKEVAQWINGIQYGETE 735
Cdd:TIGR01123 232 -GMEVEERRIDIDELKAFVEAGE--IVFACGTAAVITPVGEIQHGGKEVVF---ASGQPGEVTKALYDELTDIQYGDFE 304
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
420-735 |
3.16e-68 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 226.22 E-value: 3.16e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 420 WGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYrtvDNKItmFRPDMNMKRMNKSAQRICLP-TFDPEELITLIGKLIQ 498
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAY---DGRL--FRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 499 QDKYLvpegkgySLYIRPTLIGTTAGLGVSTPD-RALLYVICCPVGPYYKTGF-KAVRLEATDYaTRAWPGGCGDKKlGA 576
Cdd:COG0115 79 ANGLE-------DGYIRPQVTRGVGGRGVFAEEyEPTVIIIASPLPAYPAEAYeKGVRVITSPY-RRAAPGGLGGIK-TG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 577 NYAPCVLPQLQAASRGYQQNLWLfGPNNNITEVGTMNAFFVFKDsktgkkELVTAPLDGTILEGVTRDSILNLAKERlep 656
Cdd:COG0115 150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIVKDG------VLVTPPLSGGILPGITRDSVIELAREL--- 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2360683871 657 sEWTISERYFTIGEVTERSkngellEAFGSGTAAIVSPIKEIGwkGEQInipllPGEQTGPLAKEVAQWINGIQYGETE 735
Cdd:COG0115 220 -GIPVEERPISLEELYTAD------EVFLTGTAAEVTPVTEID--GRPI-----GDGKPGPVTRRLRELYTDIVRGEAE 284
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
446-698 |
1.19e-31 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 122.85 E-value: 1.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 446 LFEGMKAYrtvDNKItmFRPDMNMKRMNKSAQRICLP-TFDPEELITLIGKLIQQDKYLVPegkgyslYIRPTLIGTTAG 524
Cdd:pfam01063 2 VFETLRVY---NGKI--FFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPGG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 525 LGVSTPD-RALLYVICCPVGPYYKTGFKAVRLEATDYAtRAWPGgcgdKKlGANYAPCVLPQLQAASRGYQQNLwLFGPN 603
Cdd:pfam01063 70 FGLPTSDpTLAIFVSALPPPPESKKKGVISSLVRRNPP-SPLPG----AK-TLNYLENVLARREAKAQGADDAL-LLDED 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 604 NNITEVGTMNaFFVFKDSKtgkkeLVTAPLDGTILEGVTRDSILNLAKERlepsEWTISERYFTIGEVTERSkngellEA 683
Cdd:pfam01063 143 GNVTEGSTSN-VFLVKGGT-----LYTPPLESGILPGITRQALLDLAKAL----GLEVEERPITLADLQEAD------EA 206
|
250
....*....|....*
gi 2360683871 684 FGSGTAAIVSPIKEI 698
Cdd:pfam01063 207 FLTNSLRGVTPVSSI 221
|
|
| HSF |
smart00415 |
heat shock factor; |
9-103 |
1.61e-30 |
|
heat shock factor;
Pssm-ID: 214654 Cd Length: 105 Bit Score: 115.46 E-value: 1.61e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 9 QPDVFVSKLYHLLQGNAYSNIIQWSTDGSKFVIWNPDQFTKVILERFFGIHTFAAFVKQLSKYNFQKAERP--------- 79
Cdd:smart00415 1 QPPPFLTKLYLLVEDPSTDKIISWSPSGKSFVIWDPEEFAKNLLPRYFKHNNFSSFVRQLNMYGFRKVDPEfqgilynft 80
|
90 100
....*....|....*....|....*
gi 2360683871 80 -DCVEFSNIHFQKDNINSLSLVKAH 103
Cdd:smart00415 81 sDQWEFANPDFVRGQPELLRNIKRK 105
|
|
| HSF_DNA-bind |
pfam00447 |
HSF-type DNA-binding; |
13-101 |
2.62e-26 |
|
HSF-type DNA-binding;
Pssm-ID: 459813 Cd Length: 98 Bit Score: 103.42 E-value: 2.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 13 FVSKLYHLLQGNAYSNIIQWSTDGSKFVIWNPDQFTKVILERFFGIHTFAAFVKQLSKYNFQKAERP-------DCVEFS 85
Cdd:pfam00447 1 FLRKLYRMLEDPETDDIISWSDDGDSFVILDPEEFAKEVLPKYFKHSNFSSFVRQLNMYGFHKVKDLsssksmgDSWEFR 80
|
90
....*....|....*.
gi 2360683871 86 NIHFQKDNINSLSLVK 101
Cdd:pfam00447 81 HPNFRRGRPDLLKNIK 96
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
432-732 |
1.56e-132 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 393.48 E-value: 1.56e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 432 SLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDKYLVPEGKGYS 511
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 512 LYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYaTRAWPGGCGDKKLGANYAPCVLPQLQAASR 591
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGEKGVSALVSSF-RRAAPGGPGAAKAGGNYAASLLAQKEAAEK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 592 GYQQNLWLFGPNNNITEVGTMNAFFVFKDsktgkkELVTAPLDGTILEGVTRDSILNLAKERlepsEWTISERYFTIGEV 671
Cdd:cd01557 160 GYDQALWLDGAHGYVAEVGTMNIFFVKDG------ELITPPLDGSILPGITRDSILELARDL----GIKVEERPITRDEL 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2360683871 672 TerskngELLEAFGSGTAAIVSPIKEIGWKGEQInipllPGEQTGPLAKEVAQWINGIQYG 732
Cdd:cd01557 230 Y------EADEVFATGTAAVVTPVGEIDYRGKEP-----GEGEVGPVTKKLYDLLTDIQYG 279
|
|
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
381-743 |
5.49e-128 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 384.88 E-value: 5.49e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 381 KVKITTTQHASKPKPNSELVFGKSFTDHMLTVEWTAEKgWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKI 460
Cdd:PRK13357 4 TLKPNPTSDEKRAIDWANLGFGYVFTDHMVVIDYKDGK-WHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 461 TMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDK-YLVPEGKGYSLYIRPTLIGTTAGLGVSTPDRALLYVIC 539
Cdd:PRK13357 83 VLFRPDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRdWVPPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 540 CPVGPYYKTGFKAVR-LEATDYaTRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFGPNN-NITEVGTMNAFFV 617
Cdd:PRK13357 163 SPVGAYFKGGVKPVSiWVSDEY-DRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHtYIEEVGGMNFFFI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 618 FKDsktgkkELVTAPLDGTILEGVTRDSILNLAKerlepsEW--TISERYFTIGEVTERSKNGELLEAFGSGTAAIVSPI 695
Cdd:PRK13357 242 TKD------GTVTPPLSGSILPGITRDSLLQLAE------DLglTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPI 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2360683871 696 KEIGWKGEQINIpllPGEQTGPLAKEVAQWINGIQYGETE--HGnWSRVV 743
Cdd:PRK13357 310 GGIKYKDKEFVI---GDGEVGPVTQKLYDELTGIQFGDVEdpHG-WIVKV 355
|
|
| HSF1 |
COG5169 |
Heat shock transcription factor [Transcription]; |
1-279 |
9.43e-104 |
|
Heat shock transcription factor [Transcription];
Pssm-ID: 227497 [Multi-domain] Cd Length: 282 Bit Score: 319.38 E-value: 9.43e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 1 MDATSRMEQPDVFVSKLYHLLQGNAYSNIIQWSTDGSKFVIWNPDQFTKVILERFFGIHTFAAFVKQLSKYNFQKAE-RP 79
Cdd:COG5169 1 MSMSSRWSQPKEFVHKLYQILEEPEYYKLIQWSPDGRSFVILDPEEFTKVILPRYFKHGNFASFVRQLNKYGFHKVShKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 80 DCVEFSN---IHFQKDN-INSLS--LVKAHQSAATPNVAAINNMNKQCTFHwdPFKVNSILSKAIGKPSFEKLVKNVDRL 153
Cdd:COG5169 81 GQRSYYNenvWEFGNKNfQLGMIelLKKIKRKKAPSNRVDSNNESKDAMMN--IEVENIILPQSELYNSLSSLSNVNQTL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 154 QGNLDELKSTNADSLRIIREINASLQTISYHQFHAYQTANFLQENFDAIKKVVCPDSCLQHQQRQPKRPKRYSLLLLIPN 233
Cdd:COG5169 159 LLYLNELKEYNYRNLRTIDDINAMLADLSMSPFADEHLKSFLQELFGAYKEVAEPQSPTQHQRGEPGQRFHNSVVPLADS 238
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2360683871 234 ASELSETPLMRFAGVFEfmNCSLDTATQWYPQLHLEAYDLLFVTVS 279
Cdd:COG5169 239 KNEVDQKGDGKVANLQN--NLSLDTATNSDSHLTIDALSAAFSTVS 282
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
420-735 |
2.90e-92 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 290.51 E-value: 2.90e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 420 WGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQ 499
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 500 DK-YLVPEGKGYSLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYATRAWPGGCGDKKLGANY 578
Cdd:TIGR01123 81 NKdWVPPYGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGLAPVSIFVTTEYDRAAPGGTGAVKVGGNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 579 APCVLPQLQAASRGYQQNLWLfGPNNN--ITEVGTMNAFFVFKDSktgkkELVTAPLDGTILEGVTRDSILNLAKERlep 656
Cdd:TIGR01123 161 AASLLAQAKAAEQGCDQVVYL-DPVEHtyIEEVGAMNFFFITGDG-----ELVTPPLSGSILPGITRDSLLQLAKDL--- 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2360683871 657 sEWTISERYFTIGEVTERSKNGEllEAFGSGTAAIVSPIKEIGWKGEQINIpllPGEQTGPLAKEVAQWINGIQYGETE 735
Cdd:TIGR01123 232 -GMEVEERRIDIDELKAFVEAGE--IVFACGTAAVITPVGEIQHGGKEVVF---ASGQPGEVTKALYDELTDIQYGDFE 304
|
|
| PLPDE_IV |
cd00449 |
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ... |
439-726 |
1.15e-79 |
|
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.
Pssm-ID: 238254 [Multi-domain] Cd Length: 256 Bit Score: 255.60 E-value: 1.15e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 439 VFHYAFELFEGMKAYrtvdnKITMFRPDMNMKRMNKSAQRICLP-TFDPEELITLIgkliqqdKYLVPEGKGYSLYIRPT 517
Cdd:cd00449 3 GLHYGDGVFEGLRAG-----KGRLFRLDEHLDRLNRSAKRLGLPiPYDREELREAL-------KELVAANNGASLYIRPL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 518 LIGTTAGLGVSTPD--RALLYVICCPVGPYYKTGFKAVRLEATDYATRAWPGGCGDKKLGaNYAPCVLPQLQAASRGYQQ 595
Cdd:cd00449 71 LTRGVGGLGVAPPPspEPTFVVFASPVGAYAKGGEKGVRLITSPDRRRAAPGGTGDAKTG-GNLNSVLAKQEAAEAGADE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 596 NLWLFGpNNNITEVGTMNAFFVFKDsktgkkELVTAPLDGTILEGVTRDSILNLAKERLepseWTISERYFTIGEVTERS 675
Cdd:cd00449 150 ALLLDD-NGYVTEGSASNVFIVKDG------ELVTPPLDGGILPGITRDSVIELAKELG----IKVEERPISLDELYAAD 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2360683871 676 kngellEAFGSGTAAIVSPIKEIGWKGEqinipllPGEQTGPLAKEVAQWI 726
Cdd:cd00449 219 ------EVFLTGTAAEVTPVTEIDGRGI-------GDGKPGPVTRKLRELL 256
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
420-735 |
3.16e-68 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 226.22 E-value: 3.16e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 420 WGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYrtvDNKItmFRPDMNMKRMNKSAQRICLP-TFDPEELITLIGKLIQ 498
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAY---DGRL--FRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 499 QDKYLvpegkgySLYIRPTLIGTTAGLGVSTPD-RALLYVICCPVGPYYKTGF-KAVRLEATDYaTRAWPGGCGDKKlGA 576
Cdd:COG0115 79 ANGLE-------DGYIRPQVTRGVGGRGVFAEEyEPTVIIIASPLPAYPAEAYeKGVRVITSPY-RRAAPGGLGGIK-TG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 577 NYAPCVLPQLQAASRGYQQNLWLfGPNNNITEVGTMNAFFVFKDsktgkkELVTAPLDGTILEGVTRDSILNLAKERlep 656
Cdd:COG0115 150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIVKDG------VLVTPPLSGGILPGITRDSVIELAREL--- 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2360683871 657 sEWTISERYFTIGEVTERSkngellEAFGSGTAAIVSPIKEIGwkGEQInipllPGEQTGPLAKEVAQWINGIQYGETE 735
Cdd:COG0115 220 -GIPVEERPISLEELYTAD------EVFLTGTAAEVTPVTEID--GRPI-----GDGKPGPVTRRLRELYTDIVRGEAE 284
|
|
| PLN03117 |
PLN03117 |
Branched-chain-amino-acid aminotransferase; Provisional |
398-735 |
3.41e-54 |
|
Branched-chain-amino-acid aminotransferase; Provisional
Pssm-ID: 178664 Cd Length: 355 Bit Score: 190.53 E-value: 3.41e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 398 ELVFGKSFTDHMLTVEWTAEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQ 477
Cdd:PLN03117 24 ELGFALVPTDYMYVAKCKQGESFSEGKIVPYGDISISPCAGILNYGQGLFEGLKAYRTEDGRITLFRPDQNALRMQTGAD 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 478 RICLPTFDPEELITLIGK-LIQQDKYLVPEGKGySLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGfKAVRLE 556
Cdd:PLN03117 104 RLCMTPPSLEQFVEAVKQtVLANKKWVPPPGKG-TLYIRPLLIGSGAVLGVAPAPEYTFLIYASPVGNYHKAS-SGLNLK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 557 ATDYATRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWL-FGPNNNITEVGTMNAFFVfkdsktgKKELV-TAPLD 634
Cdd:PLN03117 182 VDHKHRRAHSGGTGGVKSCTNYSPVVKSLIEAKSSGFSDVLFLdAATGKNIEELSACNIFIL-------KGNIVsTPPTS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 635 GTILEGVTRDSILNLAKErlepSEWTISERYFTIGEVTERSkngellEAFGSGTAAIVSPIKEIGWKGEQINIPllPGEQ 714
Cdd:PLN03117 255 GTILPGVTRKSISELARD----IGYQVEERDVSVDELLEAE------EVFCTGTAVVVKAVETVTFHDKKVKYR--TGEE 322
|
330 340
....*....|....*....|.
gi 2360683871 715 TgpLAKEVAQWINGIQYGETE 735
Cdd:PLN03117 323 A--LSTKLHLILTNIQMGVVE 341
|
|
| PLN02782 |
PLN02782 |
Branched-chain amino acid aminotransferase |
401-740 |
1.37e-51 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 215418 Cd Length: 403 Bit Score: 185.05 E-value: 1.37e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 401 FGKSFTDHMLTVEWTAEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRIC 480
Cdd:PLN02782 77 FGLVPTDYMYIMKCNRDGEFSKGELQRFGNIELSPSAGVLNYGQGLFEGLKAYRKEDGNILLFRPEENAIRMRNGAERMC 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 481 LPTFDPEELITLIGKLIQQDKYLV-PEGKGySLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATD 559
Cdd:PLN02782 157 MPAPTVEQFVEAVKETVLANKRWVpPPGKG-SLYIRPLLMGSGAVLGLAPAPEYTFLIYVSPVGNYFKEGVAPINLIVEN 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 560 YATRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFGPNNN-ITEVGTMNAFFVfkdsktgKKELVTAP-LDGTI 637
Cdd:PLN02782 236 EFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYLDCVHKKyLEEVSSCNIFIV-------KDNVISTPaIKGTI 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 638 LEGVTRDSILNLAKERlepsEWTISERYFTIGEVTERSkngellEAFGSGTAAIVSPIKEIGWKGEQINIpllpGEQT-G 716
Cdd:PLN02782 309 LPGITRKSIIDVARSQ----GFQVEERNVTVDELLEAD------EVFCTGTAVVVSPVGSITYKGKRVSY----GEGGfG 374
|
330 340
....*....|....*....|....*
gi 2360683871 717 PLAKEVAQWINGIQYGETEHG-NWS 740
Cdd:PLN02782 375 TVSQQLYTVLTSLQMGLIEDNmNWT 399
|
|
| PLN02259 |
PLN02259 |
branched-chain-amino-acid aminotransferase 2 |
399-729 |
4.56e-44 |
|
branched-chain-amino-acid aminotransferase 2
Pssm-ID: 177901 Cd Length: 388 Bit Score: 163.35 E-value: 4.56e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 399 LVFGKSFTDHMLTVEWTAEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQR 478
Cdd:PLN02259 61 LGFGLNPADYMYVMKCSKDGEFTQGELSPYGNIQLSPSAGVLNYGQAIYEGTKAYRKENGKLLLFRPDHNAIRMKLGAER 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 479 ICLPTFDPEELITLIGKL-IQQDKYLVPEGKGySLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEA 557
Cdd:PLN02259 141 MLMPSPSVDQFVNAVKQTaLANKRWVPPAGKG-TLYIRPLLMGSGPILGLGPAPEYTFIVYASPVGNYFKEGMAALNLYV 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 558 TDYATRAWPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFGPNNNITEVGTMNAFFVFKDsktgkKELVTAPLDGTI 637
Cdd:PLN02259 220 EEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVLYLDSVKKKYLEEASSCNVFVVKG-----RTISTPATNGTI 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 638 LEGVTRDSILNLAKERlepsEWTISERYFTIGEVTERSkngellEAFGSGTAAIVSPIKEIGWKGEQINI---------- 707
Cdd:PLN02259 295 LEGITRKSVMEIASDQ----GYQVVEKAVHVDEVMDAD------EVFCTGTAVVVAPVGTITYQEKRVEYktgdesvcqk 364
|
330 340
....*....|....*....|....
gi 2360683871 708 --PLLPGEQTGpLAKEVAQWINGI 729
Cdd:PLN02259 365 lrSVLVGIQTG-LIEDNKGWVTDI 387
|
|
| PLN02883 |
PLN02883 |
Branched-chain amino acid aminotransferase |
406-735 |
1.19e-40 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 178471 Cd Length: 384 Bit Score: 153.72 E-value: 1.19e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 406 TDHMLTVEWTAEKGWGTPEIKPYQNLSLDPSAVVFHYAFELFEGMKAYRTVDNKITMFRPDMNMKRMNKSAQRICLPTFD 485
Cdd:PLN02883 64 TDFMFATKSCRDGNFEQGYLSRYGNIELNPAAGILNYGQGLIEGMKAYRGEDGRILLFRPELNAMRMKIGAERMCMHSPS 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 486 PEELITLIGK-LIQQDKYLVPEGKGySLYIRPTLIGTTAGLGVSTPDRALLYVICCPVGPYYKTGFKAVRLEATDYATRA 564
Cdd:PLN02883 144 VHQFIEGVKQtVLANRRWVPPPGKG-SLYLRPLLFGSGASLGVAAAPEYTFLVFGSPVQNYFKEGTAALNLYVEEVIPRA 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 565 WPGGCGDKKLGANYAPCVLPQLQAASRGYQQNLWLFG-PNNNITEVGTMNAFFVFKDSktgkkeLVTAPLDGTILEGVTR 643
Cdd:PLN02883 223 YLGGTGGVKAISNYGPVLEVMRRAKSRGFSDVLYLDAdTGKNIEEVSAANIFLVKGNI------IVTPATSGTILGGITR 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 644 DSILNLAKERlepsEWTISERYFTIGEVTERSkngellEAFGSGTAAIVSPIKEIGWKGEQINIPLlpgeQTGPLAKEVA 723
Cdd:PLN02883 297 KSIIEIALDL----GYKVEERRVPVEELKEAE------EVFCTGTAAGVASVGSITFKNTRTEYKV----GDGIVTQQLR 362
|
330
....*....|..
gi 2360683871 724 QWINGIQYGETE 735
Cdd:PLN02883 363 SILLGIQTGSIQ 374
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
446-698 |
1.19e-31 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 122.85 E-value: 1.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 446 LFEGMKAYrtvDNKItmFRPDMNMKRMNKSAQRICLP-TFDPEELITLIGKLIQQDKYLVPegkgyslYIRPTLIGTTAG 524
Cdd:pfam01063 2 VFETLRVY---NGKI--FFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPGG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 525 LGVSTPD-RALLYVICCPVGPYYKTGFKAVRLEATDYAtRAWPGgcgdKKlGANYAPCVLPQLQAASRGYQQNLwLFGPN 603
Cdd:pfam01063 70 FGLPTSDpTLAIFVSALPPPPESKKKGVISSLVRRNPP-SPLPG----AK-TLNYLENVLARREAKAQGADDAL-LLDED 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 604 NNITEVGTMNaFFVFKDSKtgkkeLVTAPLDGTILEGVTRDSILNLAKERlepsEWTISERYFTIGEVTERSkngellEA 683
Cdd:pfam01063 143 GNVTEGSTSN-VFLVKGGT-----LYTPPLESGILPGITRQALLDLAKAL----GLEVEERPITLADLQEAD------EA 206
|
250
....*....|....*
gi 2360683871 684 FGSGTAAIVSPIKEI 698
Cdd:pfam01063 207 FLTNSLRGVTPVSSI 221
|
|
| HSF |
smart00415 |
heat shock factor; |
9-103 |
1.61e-30 |
|
heat shock factor;
Pssm-ID: 214654 Cd Length: 105 Bit Score: 115.46 E-value: 1.61e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 9 QPDVFVSKLYHLLQGNAYSNIIQWSTDGSKFVIWNPDQFTKVILERFFGIHTFAAFVKQLSKYNFQKAERP--------- 79
Cdd:smart00415 1 QPPPFLTKLYLLVEDPSTDKIISWSPSGKSFVIWDPEEFAKNLLPRYFKHNNFSSFVRQLNMYGFRKVDPEfqgilynft 80
|
90 100
....*....|....*....|....*
gi 2360683871 80 -DCVEFSNIHFQKDNINSLSLVKAH 103
Cdd:smart00415 81 sDQWEFANPDFVRGQPELLRNIKRK 105
|
|
| HSF_DNA-bind |
pfam00447 |
HSF-type DNA-binding; |
13-101 |
2.62e-26 |
|
HSF-type DNA-binding;
Pssm-ID: 459813 Cd Length: 98 Bit Score: 103.42 E-value: 2.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 13 FVSKLYHLLQGNAYSNIIQWSTDGSKFVIWNPDQFTKVILERFFGIHTFAAFVKQLSKYNFQKAERP-------DCVEFS 85
Cdd:pfam00447 1 FLRKLYRMLEDPETDDIISWSDDGDSFVILDPEEFAKEVLPKYFKHSNFSSFVRQLNMYGFHKVKDLsssksmgDSWEFR 80
|
90
....*....|....*.
gi 2360683871 86 NIHFQKDNINSLSLVK 101
Cdd:pfam00447 81 HPNFRRGRPDLLKNIK 96
|
|
| ilvE_I |
TIGR01122 |
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ... |
439-739 |
4.16e-26 |
|
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 130192 Cd Length: 298 Bit Score: 108.99 E-value: 4.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 439 VFHYAFELFEGMKAYRTvDNKITMFRPDMNMKRMNKSAQRICLP-TFDPEELITLIGKLIQQDKYlvpegkgYSLYIRPT 517
Cdd:TIGR01122 20 ALHYGTGVFEGIRAYDT-DKGPAIFRLKEHIQRLYDSAKIYRMEiPYSKEELMEATRETLRKNNL-------RSAYIRPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 518 LIGTTAGLGVSTPDRALLYVICC--PVGPYYKTGF--KAVRLEATDYaTRAWPGGC-GDKKLGANYAPCVLPQLQAASRG 592
Cdd:TIGR01122 92 VFRGDGDLGLNPRAGYKPDVIIAawPWGAYLGEEAleKGIDAKVSSW-RRNAPNTIpTAAKAGGNYLNSLLAKSEARRHG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 593 YQQNLWLfGPNNNITEvGTMNAFFVFKDSktgkkELVTAPLDGTILEGVTRDSILNLAKERlepsEWTISERYFTIGEVT 672
Cdd:TIGR01122 171 YDEAILL-DVEGYVAE-GSGENIFIVKDG-----VLFTPPVTSSILPGITRDTVITLAKEL----GIEVVEQPISREELY 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2360683871 673 ERSkngellEAFGSGTAAIVSPIKEIgwKGEQINipllPGEQtGPLAKEVAQWINGIQYGETE-HGNW 739
Cdd:TIGR01122 240 TAD------EAFFTGTAAEITPIREV--DGRKIG----NGRR-GPVTKKLQEAFFDLVTGGTEdYWGW 294
|
|
| PRK06606 |
PRK06606 |
branched-chain amino acid transaminase; |
440-739 |
9.94e-25 |
|
branched-chain amino acid transaminase;
Pssm-ID: 235841 Cd Length: 306 Bit Score: 105.23 E-value: 9.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 440 FHYAFELFEGMKAYRTVDNKiTMFRPDMNMKRMNKSAQ--RICLPtFDPEELITLIGKLIQQDKYlvpegkgYSLYIRPt 517
Cdd:PRK06606 30 LHYGTGVFEGIRAYDTPKGP-AIFRLREHTKRLFNSAKilRMEIP-YSVDELMEAQREVVRKNNL-------KSAYIRP- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 518 LIGTTA-GLGVSTPD---RALLYVIccPVGPY-----YKTGFKA-----VRLEATDYATRAwpggcgdkKLGANYAPCVL 583
Cdd:PRK06606 100 LVFVGDeGLGVRPHGlptDVAIAAW--PWGAYlgeeaLEKGIRVkvsswTRHAPNSIPTRA--------KASGNYLNSIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 584 PQLQAASRGYQQNLwLFGPNNNITEVGTMNAFFVfkdsKTGKkeLVTAPLDGTILEGVTRDSILNLAKErlepsewtise 663
Cdd:PRK06606 170 AKTEARRNGYDEAL-LLDVEGYVSEGSGENIFIV----RDGV--LYTPPLTSSILEGITRDTVITLAKD----------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 664 ryftIG-EVTERS-KNGELL---EAFGSGTAAIVSPIKEIGwkgeqiNIPLLPGEQtGPLAKEVAQWINGIQYGETE-HG 737
Cdd:PRK06606 232 ----LGiEVIERRiTRDELYiadEVFFTGTAAEVTPIREVD------GRQIGNGKR-GPITEKLQSAYFDIVRGRTEkYA 300
|
..
gi 2360683871 738 NW 739
Cdd:PRK06606 301 HW 302
|
|
| D-AAT_like |
cd01558 |
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ... |
439-698 |
8.24e-21 |
|
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.
Pssm-ID: 238799 [Multi-domain] Cd Length: 270 Bit Score: 93.05 E-value: 8.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 439 VFHYAFELFEGMKAYRTvdnkiTMFRPDMNMKRMNKSAQRICLPT-FDPEELITLIGKLIQQDKylVPEGKGYslyIRPT 517
Cdd:cd01558 20 GFLFGDGVYEVIRVYNG-----KPFALDEHLDRLYRSAKELRIDIpYTREELKELIRELVAKNE--GGEGDVY---IQVT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 518 LIGTTAGLGVSTPDRALLYVIC----CPVGPYYKTGFKAVRLEatdyaTRAWpGGCGDKKLgaNYAPCVLPQLQAASRGY 593
Cdd:cd01558 90 RGVGPRGHDFPKCVKPTVVIITqplpLPPAELLEKGVRVITVP-----DIRW-LRCDIKSL--NLLNNVLAKQEAKEAGA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 594 QQnLWLFGPNNNITEVGTMNAFFVfkdsKTGKkeLVTAPLDGTILEGVTRDSILNLAKERLEPSEwtisERYFTIGEVTE 673
Cdd:cd01558 162 DE-AILLDADGLVTEGSSSNVFIV----KNGV--LVTPPLDNGILPGITRATVIELAKELGIPVE----ERPFSLEELYT 230
|
250 260
....*....|....*....|....*
gi 2360683871 674 RSkngellEAFGSGTAAIVSPIKEI 698
Cdd:cd01558 231 AD------EVFLTSTTAEVMPVVEI 249
|
|
| ADCL_like |
cd01559 |
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ... |
440-673 |
2.82e-12 |
|
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.
Pssm-ID: 238800 [Multi-domain] Cd Length: 249 Bit Score: 67.33 E-value: 2.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 440 FHYAFELFEGMKAYrtvDNKITMFrpDMNMKRMNKSAQRICLPTFDPEELITLIGKLIQQDKylVPEGkgyslYIRPTLI 519
Cdd:cd01559 4 FAYGDGVFETMRAL---DGRLFLL--DAHLARLERSARRLGIPEPDLPRLRAALESLLAAND--IDEG-----RIRLILS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 520 GTTAGLGVSTPDRALLYVICcPVGPY-YKTGFKAVRLEATDYATRAWPGGCGDKKLgaNYAPCVLPQLQAASRGYQQNLW 598
Cdd:cd01559 72 RGPGGRGYAPSVCPGPALYV-SVIPLpPAWRQDGVRLITCPVRLGEQPLLAGLKHL--NYLENVLAKREARDRGADEALF 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2360683871 599 LfGPNNNITEVGTMNAFFVfKDSktgkkELVTAPLDGTILEGVTRDSILNLAKERLEPsewtISERYFTIGEVTE 673
Cdd:cd01559 149 L-DTDGRVIEGTASNLFFV-KDG-----ELVTPSLDRGGLAGITRQRVIELAAAKGYA----VDERPLRLEDLLA 212
|
|
| PRK08320 |
PRK08320 |
branched-chain amino acid aminotransferase; Reviewed |
447-698 |
1.95e-11 |
|
branched-chain amino acid aminotransferase; Reviewed
Pssm-ID: 236238 [Multi-domain] Cd Length: 288 Bit Score: 65.28 E-value: 1.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 447 FEGMKAYrtvDNKItmFRPDMNMKRMNKSAQRICL-PTFDPEELITLIGKLIQQDKYlvpegkgYSLYIRPTLigtTAGL 525
Cdd:PRK08320 33 FEGIRAY---NGRV--FRLKEHIDRLYDSAKAIMLeIPLSKEEMTEIVLETLRKNNL-------RDAYIRLVV---SRGV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 526 GVSTPD-----RALLYVICCPVGPY----YKTGFKAVRLeatdyATRAWPGGCGD---KKLgaNYAPCVLPQLQAASRGY 593
Cdd:PRK08320 98 GDLGLDprkcpKPTVVCIAEPIGLYpgelYEKGLKVITV-----STRRNRPDALSpqvKSL--NYLNNILAKIEANLAGV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 594 QQNLwLFGPNNNITEvGTMNAFFVFKDSKtgkkeLVTAPLDGTILEGVTRDSILNLAKERlepsEWTISERYFTIGEVTE 673
Cdd:PRK08320 171 DEAI-MLNDEGYVAE-GTGDNIFIVKNGK-----LITPPTYAGALEGITRNAVIEIAKEL----GIPVREELFTLHDLYT 239
|
250 260
....*....|....*....|....*
gi 2360683871 674 RSkngellEAFGSGTAAIVSPIKEI 698
Cdd:PRK08320 240 AD------EVFLTGTAAEVIPVVKV 258
|
|
| PRK06680 |
PRK06680 |
D-amino acid aminotransferase; Reviewed |
581-705 |
9.80e-11 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 180656 [Multi-domain] Cd Length: 286 Bit Score: 63.41 E-value: 9.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 581 CVLPQL----QAASRGYQQnLWLFGpNNNITEVGTMNAFFVFKDSKtgkkeLVTAPLDGTILEGVTRDSILNLAKERlep 656
Cdd:PRK06680 152 GLLPNVlakqAAKEAGAQE-AWMVD-DGFVTEGASSNAWIVTKDGK-----LVTRPADNFILPGITRHTLIDLAKEL--- 221
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2360683871 657 sEWTISERYFTIGEVTERSkngellEAFGSGTAAIVSPIKEIGwkGEQI 705
Cdd:PRK06680 222 -GLEVEERPFTLQEAYAAR------EAFITAASSFVFPVVQID--GKQI 261
|
|
| PRK07544 |
PRK07544 |
branched-chain amino acid aminotransferase; Validated |
441-699 |
3.73e-09 |
|
branched-chain amino acid aminotransferase; Validated
Pssm-ID: 181025 Cd Length: 292 Bit Score: 58.45 E-value: 3.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 441 HYAFELFEGMKAYrtvDNKItmFRPDMNMKRMNKSAQRI--CLPtFDPEElitligklIQQDKYLVPEGKGYS-LYIRPT 517
Cdd:PRK07544 33 HYASSVFEGERAY---GGKI--FKLREHSERLRRSAELLdfEIP-YSVAE--------IDAAKKETLAANGLTdAYVRPV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 518 LIGTTAGLGVSTP-DRALLYVICCPVGPYY--KTGFKAVRLEATDY---ATRAWPggCGDKKLGAnYAPCVLPQLQAASR 591
Cdd:PRK07544 99 AWRGSEMMGVSAQqNKIHLAIAAWEWPSYFdpEAKMKGIRLDIAKWrrpDPETAP--SAAKAAGL-YMICTISKHAAEAK 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 592 GYQQNLwLFGPNNNITEVGTMNAFFVfKDSktgkkELVTaPLDGTILEGVTRDSILNLAKERlepsEWTISERYFTIGEV 671
Cdd:PRK07544 176 GYADAL-MLDYRGYVAEATGANIFFV-KDG-----VIHT-PTPDCFLDGITRQTVIELAKRR----GIEVVERHIMPEEL 243
|
250 260
....*....|....*....|....*...
gi 2360683871 672 TERSkngellEAFGSGTAAIVSPIKEIG 699
Cdd:PRK07544 244 AGFS------ECFLTGTAAEVTPVSEIG 265
|
|
| PRK12479 |
PRK12479 |
branched-chain-amino-acid transaminase; |
440-721 |
9.45e-07 |
|
branched-chain-amino-acid transaminase;
Pssm-ID: 183549 [Multi-domain] Cd Length: 299 Bit Score: 51.49 E-value: 9.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 440 FHYAFELFEGMKAYRTvdnkiTMFRPDMNMKRMNKSAQRICLP---TFdpEELITLIGKLIQQDKY-------LVPEGKG 509
Cdd:PRK12479 27 FLYGDGVFEGIRSYGG-----NVFCLKEHVKRLYESAKSILLTiplTV--DEMEEAVLQTLQKNEYadayirlIVSRGKG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 510 yslyirptligtTAGLGVSTPDRALLYVICCPVGPY----YKTGFKAVRLEATdyatRAWPGGCGDKKLGANYAPCVLPQ 585
Cdd:PRK12479 100 ------------DLGLDPRSCVKPSVIIIAEQLKLFpqefYDNGLSVVSVASR----RNTPDALDPRIKSMNYLNNVLVK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 586 LQAASRGYQQNLWLfGPNNNITEvGTMNAFFVFKDSKtgkkeLVTAPLDGTILEGVTRDSILNLAKERLEPSEwtisERY 665
Cdd:PRK12479 164 IEAAQAGVLEALML-NQQGYVCE-GSGDNVFVVKDGK-----VLTPPSYLGALEGITRNSVIELCERLSIPCE----ERP 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2360683871 666 FTIGEVTERSkngellEAFGSGTAAIVSPI-----KEIGwKGEqinipllPGEQTGPLAKE 721
Cdd:PRK12479 233 FTRHDVYVAD------EVFLTGTAAELIPVvkvdsREIG-DGK-------PGSVTKQLTEE 279
|
|
| PRK13356 |
PRK13356 |
branched-chain amino acid aminotransferase; |
466-698 |
2.53e-06 |
|
branched-chain amino acid aminotransferase;
Pssm-ID: 237362 Cd Length: 286 Bit Score: 49.95 E-value: 2.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 466 DMNMKRMNKSAQRICL-PTFDPEELITLIGKLIQqdKYlvpeGKGYSLYIRPTLIGTTAGLGVSTPD-RALLYVIC---C 540
Cdd:PRK13356 51 DLHCARVNRSAEALGLkPTVSAEEIEALAREGLK--RF----DPDTALYIRPMYWAEDGFASGVAPDpESTRFALCleeA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 541 PVGPyyKTGFKAVRleaTDYAtRAWPGgCG--DKKlganyAPCVLPQ-----LQAASRGYQQNLWLfGPNNNITEVGTMN 613
Cdd:PRK13356 125 PMPE--PTGFSLTL---SPFR-RPTLE-MAptDAK-----AGCLYPNnaralREARSRGFDNALVL-DMLGNVAETATSN 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 614 AFFVfKDSktgkkELVTAPLDGTILEGVTRDSILNLakerLEPSEWTISERYFTIGEVTERSkngellEAFGSGTAAIVS 693
Cdd:PRK13356 192 VFMV-KDG-----VVFTPVPNGTFLNGITRQRVIAL----LREDGVTVVETTLTYEDFLEAD------EVFSTGNYSKVV 255
|
....*
gi 2360683871 694 PIKEI 698
Cdd:PRK13356 256 PVTRF 260
|
|
| PRK12400 |
PRK12400 |
D-amino acid aminotransferase; Reviewed |
466-720 |
6.98e-06 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 171470 Cd Length: 290 Bit Score: 48.47 E-value: 6.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 466 DMNMKRMNKSAQRI--CLPtFDPEELITLIGKLIQQDK-------YL-VPEG-----KGYSLYIRPTLIGTtaglgVSTP 530
Cdd:PRK12400 51 DPHITRLYRSMEEIelTLP-FSKAELITLLYKLIENNNfhedgtiYLqVSRGvqartHTFSYDVPPTIYAY-----ITKK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 531 DRALLYViccpvgpyyKTGFKAVRLEATDYATrawpggCGDKKLgaNYAPCVLPQLQAASRGYQQNLWLfgpNNNITEVG 610
Cdd:PRK12400 125 ERPALWI---------EYGVRAISEPDTRWLR------CDIKSL--NLLPNILAATKAERKGCKEALFV---RNGTVTEG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 611 TMNAFFVFKDSKtgkkeLVTAPLDGTILEGVTRDSILNLAKERLEPsewtISERYFTIGEVTERSkngellEAFGSGTAA 690
Cdd:PRK12400 185 SHSNFFLIKNGT-----LYTHPANHLILNGIIRQYVLSLAKTLRIP----VQEELFSVRDVYQAD------ECFFTGTTI 249
|
250 260 270
....*....|....*....|....*....|
gi 2360683871 691 IVSPIKEIgwKGEQINipllpGEQTGPLAK 720
Cdd:PRK12400 250 EILPMTHL--DGTAIQ-----DGQVGPITK 272
|
|
| PLN02845 |
PLN02845 |
Branched-chain-amino-acid aminotransferase-like protein |
535-719 |
2.50e-05 |
|
Branched-chain-amino-acid aminotransferase-like protein
Pssm-ID: 215454 [Multi-domain] Cd Length: 336 Bit Score: 46.93 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 535 LYVICCPVGPYY--KTGFKAVR----LEATDYATrawpggcgdkKLGANYAPCVLPQLQAASRGYQQNLWLFGpNNNITE 608
Cdd:PLN02845 150 FYAVVIEDTYAQdrPEGVKVVTssvpIKPPQFAT----------VKSVNYLPNALSQMEAEERGAFAGIWLDE-EGFVAE 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2360683871 609 VGTMNAFFVFKDsktgkKELVTAPLDgTILEGVTRDSILNLAKERLEPSEW-TISERYFTIGEVtERSKngellEAFGSG 687
Cdd:PLN02845 219 GPNMNVAFLTND-----GELVLPPFD-KILSGCTARRVLELAPRLVSPGDLrGVKQRKISVEEA-KAAD-----EMMLIG 286
|
170 180 190
....*....|....*....|....*....|..
gi 2360683871 688 TAAIVSPIkeIGWKGEQINipllpGEQTGPLA 719
Cdd:PLN02845 287 SGVPVLPI--VSWDGQPIG-----DGKVGPIT 311
|
|
| |
