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Conserved domains on  [gi|53755789|emb|CAH17292|]
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hypothetical protein plpp0115 (plasmid) [Legionella pneumophila str. Paris]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 6-158 8.98e-43

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


:

Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 142.69  E-value: 8.98e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789   6 RIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVV 85
Cdd:cd00464   1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIATGGGAV 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 53755789  86 LALKN-CQLLRNEMTVFLDVSTPVQIERTARNSANLLPVPSWRDFFDQLHDERDSLYKEVATLTVHGDDGKLEE 158
Cdd:cd00464  81 LREENrRLLLENGIVVWLDASPEELLERLARDKTRPLLQDEDPERLRELLEEREPLYREVADLTIDTDELSPEE 154
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 194-255 1.35e-10

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 57.59  E-value: 1.35e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53755789 194 TRVDLSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIALYHEQ 255
Cdd:COG2197  66 LRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRL 127
 
Name Accession Description Interval E-value
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 6-158 8.98e-43

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 142.69  E-value: 8.98e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789   6 RIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVV 85
Cdd:cd00464   1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIATGGGAV 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 53755789  86 LALKN-CQLLRNEMTVFLDVSTPVQIERTARNSANLLPVPSWRDFFDQLHDERDSLYKEVATLTVHGDDGKLEE 158
Cdd:cd00464  81 LREENrRLLLENGIVVWLDASPEELLERLARDKTRPLLQDEDPERLRELLEEREPLYREVADLTIDTDELSPEE 154
aroK PRK00131
shikimate kinase; Reviewed
 1-167 1.08e-28

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 106.81  E-value: 1.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    1 MNQPQRIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTT 80
Cdd:PRK00131   1 MLKGPNIVLIGFMGAGKSTIGRLLAKRLGYDFIDTDHLIEARAGKSIPEIFEEEGEAAFRELEEEVLAELLARHNLVIST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789   81 DSSVVLALKNCQLLRNEMTV-FLDVSTPVQIERTARNSAN-LLPVPSWRDFFDQLHDERDSLYKEVATLTVHGDDGKLEE 158
Cdd:PRK00131  81 GGGAVLREENRALLRERGTVvYLDASFEELLRRLRRDRNRpLLQTNDPKEKLRDLYEERDPLYEEVADITVETDGRSPEE 160


                 ....*....
gi 53755789  159 HTRCIAKAI 167
Cdd:PRK00131 161 VVNEILEKL 169
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 7-167 1.10e-28

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 106.75  E-value: 1.10e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789   7 IFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVVL 86
Cdd:COG0703   1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIATGGGAVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789  87 ALKNCQLLRNE-MTVFLDVSTPVQIERTARNSAN-LLPVPSWRDFFDQLHDERDSLYKEVATLTVHGDDGKLEEHTRCIA 164
Cdd:COG0703  81 SPENRELLKEHgTVVYLDASPETLLERLRRDDNRpLLQGEDPRERLEELLAEREPLYREVADITVDTDGRSPEEVVDEIL 160


                ...
gi 53755789 165 KAI 167
Cdd:COG0703 161 EAL 163
SKI pfam01202
Shikimate kinase;
14-158 4.16e-20

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 83.79  E-value: 4.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    14 GAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVVLALKNCQL 93
Cdd:pfam01202   2 GAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIATGGGAVLSEENRDL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 53755789    94 LRNE-MTVFLDVSTPVQIERTARNSAN-LLPVPS-WRDFFDQLHDERDSLYKEVATLTVHGDDGKLEE 158
Cdd:pfam01202  82 LKERgIVIYLDAPLEVLLERLKRDKTRpLLQNKDpEEELLELLFEERDPLYEEAADIVIDTDESSPEE 149
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 194-255 1.35e-10

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 57.59  E-value: 1.35e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53755789 194 TRVDLSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIALYHEQ 255
Cdd:COG2197  66 LRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRL 127
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 196-251 1.70e-10

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 55.23  E-value: 1.70e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 53755789    196 VDLSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIAL 251
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRL 57
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 198-251 4.59e-09

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 51.38  E-value: 4.59e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 53755789 198 LSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIAL 251
Cdd:cd06170   1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAY 54
GerE pfam00196
Bacterial regulatory proteins, luxR family;
198-251 1.85e-08

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 49.51  E-value: 1.85e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 53755789   198 LSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIAL 251
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRM 56
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
195-254 1.29e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 38.72  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 53755789  195 RVD-LSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIALYHE 254
Cdd:PRK09958 140 KLDsLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQR 200
 
Name Accession Description Interval E-value
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 6-158 8.98e-43

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 142.69  E-value: 8.98e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789   6 RIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVV 85
Cdd:cd00464   1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIATGGGAV 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 53755789  86 LALKN-CQLLRNEMTVFLDVSTPVQIERTARNSANLLPVPSWRDFFDQLHDERDSLYKEVATLTVHGDDGKLEE 158
Cdd:cd00464  81 LREENrRLLLENGIVVWLDASPEELLERLARDKTRPLLQDEDPERLRELLEEREPLYREVADLTIDTDELSPEE 154
aroK PRK00131
shikimate kinase; Reviewed
 1-167 1.08e-28

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 106.81  E-value: 1.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    1 MNQPQRIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTT 80
Cdd:PRK00131   1 MLKGPNIVLIGFMGAGKSTIGRLLAKRLGYDFIDTDHLIEARAGKSIPEIFEEEGEAAFRELEEEVLAELLARHNLVIST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789   81 DSSVVLALKNCQLLRNEMTV-FLDVSTPVQIERTARNSAN-LLPVPSWRDFFDQLHDERDSLYKEVATLTVHGDDGKLEE 158
Cdd:PRK00131  81 GGGAVLREENRALLRERGTVvYLDASFEELLRRLRRDRNRpLLQTNDPKEKLRDLYEERDPLYEEVADITVETDGRSPEE 160


                 ....*....
gi 53755789  159 HTRCIAKAI 167
Cdd:PRK00131 161 VVNEILEKL 169
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 7-167 1.10e-28

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 106.75  E-value: 1.10e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789   7 IFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVVL 86
Cdd:COG0703   1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIATGGGAVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789  87 ALKNCQLLRNE-MTVFLDVSTPVQIERTARNSAN-LLPVPSWRDFFDQLHDERDSLYKEVATLTVHGDDGKLEEHTRCIA 164
Cdd:COG0703  81 SPENRELLKEHgTVVYLDASPETLLERLRRDDNRpLLQGEDPRERLEELLAEREPLYREVADITVDTDGRSPEEVVDEIL 160


                ...
gi 53755789 165 KAI 167
Cdd:COG0703 161 EAL 163
SKI pfam01202
Shikimate kinase;
14-158 4.16e-20

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 83.79  E-value: 4.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    14 GAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVVLALKNCQL 93
Cdd:pfam01202   2 GAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIATGGGAVLSEENRDL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 53755789    94 LRNE-MTVFLDVSTPVQIERTARNSAN-LLPVPS-WRDFFDQLHDERDSLYKEVATLTVHGDDGKLEE 158
Cdd:pfam01202  82 LKERgIVIYLDAPLEVLLERLKRDKTRpLLQNKDpEEELLELLFEERDPLYEEAADIVIDTDESSPEE 149
aroL PRK03731
shikimate kinase AroL;
1-152 3.18e-19

shikimate kinase AroL;


Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 81.91  E-value: 3.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    1 MNQPqrIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSlCTQEHIVVTT 80
Cdd:PRK03731   1 MTQP--LFLVGARGCGKTTVGMALAQALGYRFVDTDQWLQSTSNMTVAEIVEREGWAGFRARESAALEA-VTAPSTVIAT 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 53755789   81 DSSVVLALKNCQLLR-NEMTVFLDVSTPVQIERTARN-SANLLPVPSWRDFFDQLHD---ERDSLYKEVATLTVHGD 152
Cdd:PRK03731  78 GGGIILTEENRHFMRnNGIVIYLCAPVSVLANRLEANpEEDQRPTLTGKPISEEVAEvlaEREALYREVAHHIIDAT 154
aroK PRK05057
shikimate kinase AroK;
1-153 6.49e-18

shikimate kinase AroK;


Pssm-ID: 235335 [Multi-domain]  Cd Length: 172  Bit Score: 78.60  E-value: 6.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    1 MNQPQRIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTT 80
Cdd:PRK05057   1 MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADIGWVFDVEGEEGFRDREEKVINELTEKQGIVLAT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53755789   81 DSSVVLALKNcqllRNEMT-----VFLDVSTPVQIERTARNSAN-LLPVPSWRDFFDQLHDERDSLYKEVATLTVHGDD 153
Cdd:PRK05057  81 GGGSVKSRET----RNRLSargvvVYLETTIEKQLARTQRDKKRpLLQVDDPREVLEALANERNPLYEEIADVTIRTDD 155
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
6-158 1.24e-16

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 78.79  E-value: 1.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    6 RIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVV 85
Cdd:PRK13951   2 RIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIERREGRSVRRIFEEDGEEYFRLKEKELLRELVERDNVVVATGGGVV 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53755789   86 LALKNCQLLRNEMTVFLDVSTPVQIERTARNSANLLpvPSWRDFFDQLHDERDSLYKEVATLtvhgDDGKLEE 158
Cdd:PRK13951  82 IDPENRELLKKEKTLFLYAPPEVLMERVTTENRPLL--REGKERIREIWERRKQFYTEFRGI----DTSKLNE 148
PRK13949 PRK13949
shikimate kinase; Provisional
 6-112 3.26e-13

shikimate kinase; Provisional


Pssm-ID: 140006 [Multi-domain]  Cd Length: 169  Bit Score: 65.91  E-value: 3.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    6 RIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVV 85
Cdd:PRK13949   3 RIFLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHEVAEFEDVVISTGGGAP 82

                         90       100
                 ....*....|....*....|....*...
gi 53755789   86 LALKNCQLL-RNEMTVFLDVSTPVQIER 112
Cdd:PRK13949  83 CFFDNMELMnASGTTVYLKVSPEVLFVR 110
PRK13947 PRK13947
shikimate kinase; Provisional
 7-172 2.10e-12

shikimate kinase; Provisional


Pssm-ID: 184412 [Multi-domain]  Cd Length: 171  Bit Score: 63.57  E-value: 2.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    7 IFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVVL 86
Cdd:PRK13947   4 IVLIGFMGTGKTTVGKRVATTLSFGFIDTDKEIEKMTGMTVAEIFEKDGEVRFRSEEKLLVKKLARLKNLVIATGGGVVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789   87 ALKNCQLLRNEMTVFLDVSTPVQIERTARNSAN--LLPVPSWRDFFDQLHDERDSLYkEVATLTVHGDDGKLEEHTRCIA 164
Cdd:PRK13947  84 NPENVVQLRKNGVVICLKARPEVILRRVGKKKSrpLLMVGDPEERIKELLKEREPFY-DFADYTIDTGDMTIDEVAEEII 162


                 ....*...
gi 53755789  165 KAILGNEK 172
Cdd:PRK13947 163 KAYLKLKN 170
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 194-255 1.35e-10

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 57.59  E-value: 1.35e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53755789 194 TRVDLSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIALYHEQ 255
Cdd:COG2197  66 LRRLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRL 127
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 196-251 1.70e-10

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 55.23  E-value: 1.70e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 53755789    196 VDLSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIAL 251
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRL 57
PLN02199 PLN02199
shikimate kinase
 7-170 3.75e-10

shikimate kinase


Pssm-ID: 177850 [Multi-domain]  Cd Length: 303  Bit Score: 58.94  E-value: 3.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    7 IFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHV-GRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVV 85
Cdd:PLN02199 105 MYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQAMnGTSVAEIFVHHGENFFRGKETDALKKLSSRYQVVVSTGGGAV 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789   86 LALKNCQLLRNEMTVFLDVSTPVQIERTARNSANLLPVpswrdffdqLHDERDSLY----KEVATLTvhgdDGKLEEHTR 161
Cdd:PLN02199 185 IRPINWKYMHKGISIWLDVPLEALAHRIAAVGTDSRPL---------LHDESGDAYsvafKRLSAIW----DERGEAYTN 251


                 ....*....
gi 53755789  162 CIAKAILGN 170
Cdd:PLN02199 252 ANARVSLEN 260
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
195-254 9.35e-10

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 56.69  E-value: 9.35e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789 195 RVDLSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIALYHE 254
Cdd:COG2771 125 APGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALR 184
PRK14021 PRK14021
bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional
 1-150 1.50e-09

bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional


Pssm-ID: 184458 [Multi-domain]  Cd Length: 542  Bit Score: 57.95  E-value: 1.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    1 MNQPQRIfIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTT 80
Cdd:PRK14021   4 TRRPQAV-IIGMMGAGKTRVGKEVAQMMRLPFADADVEIEREIGMSIPSYFEEYGEPAFREVEADVVADMLEDFDGIFSL 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53755789   81 DSSVVLALKNCQLLRNEM-----TVFLDVSTPVQIERTARNSANLLPVPSWRDFFDQLHDERDSLYKEVATLTVH 150
Cdd:PRK14021  83 GGGAPMTPSTQHALASYIahggrVVYLDADPKEAMERANRGGGRPMLNGDANKRWKKLFKQRDPVFRQVANVHVH 157
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 198-251 4.59e-09

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 51.38  E-value: 4.59e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 53755789 198 LSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIAL 251
Cdd:cd06170   1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAY 54
GerE pfam00196
Bacterial regulatory proteins, luxR family;
198-251 1.85e-08

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 49.51  E-value: 1.85e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 53755789   198 LSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIAL 251
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRM 56
PRK13946 PRK13946
shikimate kinase; Provisional
 7-157 1.94e-08

shikimate kinase; Provisional


Pssm-ID: 184411 [Multi-domain]  Cd Length: 184  Bit Score: 52.62  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    7 IFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAFYECQFDILKSLCTQEHIVVTTDSSVVL 86
Cdd:PRK13946  13 VVLVGLMGAGKSTVGRRLATMLGLPFLDADTEIERAARMTIAEIFAAYGEPEFRDLERRVIARLLKGGPLVLATGGGAFM 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53755789   87 ALKNCQLLR-NEMTVFLDVSTPVQIERTARNSAN-LLPVPSWRDFFDQLHDERDSLYKEvATLTVHGDDGKLE 157
Cdd:PRK13946  93 NEETRAAIAeKGISVWLKADLDVLWERVSRRDTRpLLRTADPKETLARLMEERYPVYAE-ADLTVASRDVPKE 164
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 189-254 6.62e-07

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 45.72  E-value: 6.62e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 53755789 189 HKVSHTRVDLSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIALYHE 254
Cdd:COG5905   4 SSSTSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALR 69
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 206-252 3.51e-06

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 46.25  E-value: 3.51e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 53755789 206 LKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIALY 252
Cdd:COG4566 146 LDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAELVRLA 192
PRK00625 PRK00625
shikimate kinase; Provisional
 7-112 9.78e-06

shikimate kinase; Provisional


Pssm-ID: 134335 [Multi-domain]  Cd Length: 173  Bit Score: 44.75  E-value: 9.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    7 IFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLY----EILGSHGSEAFYECQFDILKSLCTqEHIVVTTDS 82
Cdd:PRK00625   3 IFLCGLPTVGKTSFGKALAKFLSLPFFDTDDLIVSNYHGALYsspkEIYQAYGEEGFCREEFLALTSLPV-IPSIVALGG 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 53755789   83 SVVLALKNCQLLRNEMT-VFLDVSTPVQIER 112
Cdd:PRK00625  82 GTLMIEPSYAHIRNRGLlVLLSLPIATIYQR 112
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
208-251 2.27e-05

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 43.92  E-value: 2.27e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 53755789 208 LLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIAL 251
Cdd:COG2909 133 LLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVAR 176
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 3-85 1.18e-04

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 42.63  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53755789    3 QPQRIFIVGHHGAGKGLLAKSVAQLLGWQFVDADLGLESHVGRHLYEILGSHGSEAF--YEcQFDILKSLCTQEHIVVTT 80
Cdd:PRK08154 132 RRRRIALIGLRGAGKSTLGRMLAARLGVPFVELNREIEREAGLSVSEIFALYGQEGYrrLE-RRALERLIAEHEEMVLAT 210


                 ....*
gi 53755789   81 DSSVV 85
Cdd:PRK08154 211 GGGIV 215
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
195-254 1.29e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 38.72  E-value: 1.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 53755789  195 RVD-LSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKELIALYHE 254
Cdd:PRK09958 140 KLDsLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQR 200
PRK10360 PRK10360
transcriptional regulator UhpA;
189-248 1.79e-03

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 38.42  E-value: 1.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 53755789  189 HKVSHTRVD-LSEQQAIYLKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDSLGCSSSKEL 248
Cdd:PRK10360 128 IKLASGRQDpLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVEL 188
HTH_23 pfam13384
Homeodomain-like domain;
206-239 2.23e-03

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 35.32  E-value: 2.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 53755789   206 LKLLAQGKTAKEIAREAHVSYRTVEGIIAKLMDS 239
Cdd:pfam13384  11 LLLLAEGLSVKEIAELLGVSRRTVYRWLKRYNEE 44
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 206-236 2.75e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 34.88  E-value: 2.75e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 53755789   206 LKLLAQGKTAKEIAREAHVSYRTVEGIIAKL 236
Cdd:pfam13518   6 VLLALEGESIKEAARLFGISRSTVYRWIRRY 36
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 4-36 4.53e-03

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 36.65  E-value: 4.53e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 53755789   4 PQRIFIVGHHGAGKGLLAKSVAQLLGWQFVDAD 36
Cdd:COG3265   1 PMVIVVMGVSGSGKSTVGQALAERLGWPFIDGD 33
YrhO COG1378
Sugar-specific transcriptional regulator TrmB [Transcription];
197-238 5.19e-03

Sugar-specific transcriptional regulator TrmB [Transcription];


Pssm-ID: 440988 [Multi-domain]  Cd Length: 238  Bit Score: 37.31  E-value: 5.19e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 53755789 197 DLSEQQA-IYLKLLAQGK-TAKEIAREAHVSYRTVEGIIAKLMD 238
Cdd:COG1378  10 GLSEYEAkVYLALLELGPaTASELAKASGVPRSRVYDVLESLEE 53
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 197-238 8.75e-03

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 34.03  E-value: 8.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 53755789   197 DLSEQQA-IYLKLLAQG-KTAKEIAREAHVSYRTVEGIIAKLMD 238
Cdd:pfam01978   5 GLSEYEAkVYLALLKLGpATADEIAEESGVPRSKVYEVLRSLED 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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