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Conserved domains on  [gi|2262527191|emb|CAG8935784|]
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unnamed protein product [Penicillium nalgiovense]

Protein Classification

cyclin family protein( domain architecture ID 1750054)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901|GO:0007049
PubMed:  14744433|30185601|15269391|15840440
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 32-310 3.00e-47

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member COG5024:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 440  Bit Score: 168.03  E-value: 3.00e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  32 KQEHDKQMARERQYVMADELS-NLTSEQLRDDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLP 110
Cdd:COG5024   152 KQAESKRESQSWQDLDATDQEdPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLP 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 111 STLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDrvPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGWSIG 190
Cdd:COG5024   232 ETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNC--PSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 191 HPTVDAFLQHAVLDDAYDPEVEHMALYILEIALFHRDFVAKLSSELARAALALSRCILNRPQ--PRHTHWSSQYDSMTLV 268
Cdd:COG5024   310 WPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQwdRTLIHYSGNYTNPDLK 389

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2262527191 269 ALSQ---QLHQPSTV----VARKYASAHYSRVSKVMeHFLNRQASLATY 310
Cdd:COG5024   390 PLNEsnkENLQNPSVhhdaIFPKYPSPTFGKASSPT-GEWIRSNSSNDS 437
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
32-310 3.00e-47

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 168.03  E-value: 3.00e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  32 KQEHDKQMARERQYVMADELS-NLTSEQLRDDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLP 110
Cdd:COG5024   152 KQAESKRESQSWQDLDATDQEdPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLP 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 111 STLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDrvPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGWSIG 190
Cdd:COG5024   232 ETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNC--PSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 191 HPTVDAFLQHAVLDDAYDPEVEHMALYILEIALFHRDFVAKLSSELARAALALSRCILNRPQ--PRHTHWSSQYDSMTLV 268
Cdd:COG5024   310 WPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQwdRTLIHYSGNYTNPDLK 389

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2262527191 269 ALSQ---QLHQPSTV----VARKYASAHYSRVSKVMeHFLNRQASLATY 310
Cdd:COG5024   390 PLNEsnkENLQNPSVhhdaIFPKYPSPTFGKASSPT-GEWIRSNSSNDS 437
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 94-188 1.02e-45

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 153.31  E-value: 1.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  94 YLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDRVPTIKELKSMCCSLYDDDM 173
Cdd:cd20559     1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSYGEEL 80

                          90
                  ....*....|....*
gi 2262527191 174 FTQMEWHVLQTLGWS 188
Cdd:cd20559    81 FIQMEMHILNTLNWD 95
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 62-190 1.58e-43

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 148.82  E-value: 1.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  62 DILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAA 141
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2262527191 142 LLIAAKYndKKDRVPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGWSIG 190
Cdd:pfam00134  81 LFIAAKY--EEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 97-183 5.00e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 69.93  E-value: 5.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191   97 DFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKdrvPTIKELKSMCCSlYDDDMFTQ 176
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP---PWTKELVHYTGY-FTEEEILR 76


                   ....*..
gi 2262527191  177 MEWHVLQ 183
Cdd:smart00385  77 MERLLLE 83
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
32-310 3.00e-47

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 168.03  E-value: 3.00e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  32 KQEHDKQMARERQYVMADELS-NLTSEQLRDDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLP 110
Cdd:COG5024   152 KQAESKRESQSWQDLDATDQEdPLMVPEYASDIFEYLLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLP 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 111 STLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDrvPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGWSIG 190
Cdd:COG5024   232 ETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNC--PSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNIS 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 191 HPTVDAFLQHAVLDDAYDPEVEHMALYILEIALFHRDFVAKLSSELARAALALSRCILNRPQ--PRHTHWSSQYDSMTLV 268
Cdd:COG5024   310 WPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQwdRTLIHYSGNYTNPDLK 389

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2262527191 269 ALSQ---QLHQPSTV----VARKYASAHYSRVSKVMeHFLNRQASLATY 310
Cdd:COG5024   390 PLNEsnkENLQNPSVhhdaIFPKYPSPTFGKASSPT-GEWIRSNSSNDS 437
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 94-188 1.02e-45

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 153.31  E-value: 1.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  94 YLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDRVPTIKELKSMCCSLYDDDM 173
Cdd:cd20559     1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSKMCCNSYGEEL 80

                          90
                  ....*....|....*
gi 2262527191 174 FTQMEWHVLQTLGWS 188
Cdd:cd20559    81 FIQMEMHILNTLNWD 95
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 62-190 1.58e-43

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 148.82  E-value: 1.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  62 DILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAA 141
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2262527191 142 LLIAAKYndKKDRVPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGWSIG 190
Cdd:pfam00134  81 LFIAAKY--EEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 46-187 6.36e-33

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 120.86  E-value: 6.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  46 VMADELSNltseqlrdDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCS 125
Cdd:cd20568     3 LMVAEYVP--------EIFEYLRELELKTLPNPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLS 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2262527191 126 KRVVYKRHYQLVGCAALLIAAKYNDKKdrVPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGW 187
Cdd:cd20568    75 KRVVSLNKLQLVGISALFIASKYEEVN--SPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 61-186 6.80e-29

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 109.93  E-value: 6.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  61 DDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCA 140
Cdd:cd20507     6 KDIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVGVT 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2262527191 141 ALLIAAKYNDKkdRVPTIKELKSMCCSLYDDDMFTQMEWHVLQTLG 186
Cdd:cd20507    86 ALLIASKYEEI--YPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 61-187 4.83e-24

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 97.41  E-value: 4.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  61 DDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCA 140
Cdd:cd20567    23 EDIYSFYRKVEPESCVPPYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVT 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2262527191 141 ALLIAAKYNDKKdrVPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGW 187
Cdd:cd20567   103 AMLIASKYEEIW--APEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 91-185 5.22e-20

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 84.30  E-value: 5.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  91 MRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKkdRVPTIKELKSMCCSLYD 170
Cdd:cd20536     1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEI--YPPEVKDLLALCCGAYT 78

                          90
                  ....*....|....*
gi 2262527191 171 DDMFTQMEWHVLQTL 185
Cdd:cd20536    79 REQICNLECIILTKL 93
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 88-187 5.13e-18

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 79.18  E-value: 5.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  88 QWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDRVPTIKELKSM-CC 166
Cdd:cd20528     3 QLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRYlCN 82

                          90       100
                  ....*....|....*....|.
gi 2262527191 167 SLYDDDMFTQMEWHVLQTLGW 187
Cdd:cd20528    83 SVYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 61-148 1.60e-17

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 78.44  E-value: 1.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  61 DDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCA 140
Cdd:cd20504     4 DDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVGTA 83


                  ....*...
gi 2262527191 141 ALLIAAKY 148
Cdd:cd20504    84 CMFIAAKY 91
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 82-186 3.51e-17

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 78.06  E-value: 3.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  82 DIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDrvPTIKEL 161
Cdd:cd20508    38 EKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKFDERCP--PCVDDF 115

                          90       100
                  ....*....|....*....|....*
gi 2262527191 162 KSMCCSLYDDDMFTQMEWHVLQTLG 186
Cdd:cd20508   116 LYICDDAYTREELLKMEREILKTLD 140
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 62-185 1.55e-16

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 75.91  E-value: 1.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  62 DILSHMLEMDNQTLPDVESID-IQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCA 140
Cdd:cd20562    11 DIYLNLRVAELKRRPLPDYMEkIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGVS 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2262527191 141 ALLIAAKYNDKkdRVPTIKELKSMCCSLYDDDMFTQMEWHVLQTL 185
Cdd:cd20562    91 CMLIASKYEEI--CAPQVEEFCYITDNTYTKQEVLEMEIDVLNAL 133
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 92-189 7.07e-16

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 72.74  E-value: 7.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  92 RPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKkdRVPTIKELKSMCCSLYDD 171
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEER--FPPEVATLCYLTDDSYSK 78

                          90
                  ....*....|....*...
gi 2262527191 172 DMFTQMEWHVLQTLGWSI 189
Cdd:cd20542    79 KQVLRMERRVLRRLRFDL 96
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 192-295 1.93e-15

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 72.27  E-value: 1.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 192 PTVDAFLQHA--VLDDAYDPEVEHMALYILEIALFHRDFVAKLSSELARAALALSRCILNRP--QPRHTHWsSQYDSMTL 267
Cdd:pfam02984   1 PTPLSFLRRFskAADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPewTETLEHY-TGYSEEDL 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2262527191 268 VALSQQLHQ--------PSTVVARKYASAHYSRVSK 295
Cdd:pfam02984  80 KPCVKLLLElllnapssKLQAVRRKYSSSKFMKVST 115
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 97-183 5.00e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 69.93  E-value: 5.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191   97 DFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKdrvPTIKELKSMCCSlYDDDMFTQ 176
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP---PWTKELVHYTGY-FTEEEILR 76


                   ....*..
gi 2262527191  177 MEWHVLQ 183
Cdd:smart00385  77 MERLLLE 83
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 61-187 6.47e-15

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 71.24  E-value: 6.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  61 DDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCA 140
Cdd:cd20561     6 EDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTA 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2262527191 141 ALLIAAKYNDKKDrvPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGW 187
Cdd:cd20561    86 AMLLASKFEEIYP--PEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 192-253 4.11e-13

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 64.64  E-value: 4.11e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2262527191 192 PTVDAFLQHAVLDDAYDPEVEHMALYILEIALFHRDFVAKLSSELARAALALSRCILNRPQP 253
Cdd:cd20537     1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPP 62
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 36-187 1.25e-12

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 65.63  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  36 DKQMARERQYVMADELSNLTSEQLRDDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFL 115
Cdd:cd20560    13 DTSLQSQSEDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYL 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2262527191 116 AINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDrvPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGW 187
Cdd:cd20560    93 AVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYP--PEVDEFVYITDDTYTKKQLLRMEHLLLKVLAF 162
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 60-187 1.36e-12

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 64.64  E-value: 1.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  60 RDDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCS-KRVVYKRHYQLVG 138
Cdd:cd20519     5 SEEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLStQTNVPKTQLQLIG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2262527191 139 CAALLIAAKYNDKkdRVPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGW 187
Cdd:cd20519    85 ITCLFIAAKLEEI--YPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 86-185 2.75e-12

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 63.73  E-value: 2.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  86 EIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKkdRVPTIKELKSMC 165
Cdd:cd20566    34 EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTALLLASKYEEM--YSPEIGDFVYIT 111

                          90       100
                  ....*....|....*....|
gi 2262527191 166 CSLYDDDMFTQMEWHVLQTL 185
Cdd:cd20566   112 DNAYTKAQIREMEMLILKEL 131
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 94-171 4.06e-12

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 61.66  E-value: 4.06e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2262527191  94 YLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKdrvPTIKELKSMCCSLYDD 171
Cdd:cd00043     1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELP---RTLKEIAKVSGVSEKE 75
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 86-185 1.37e-11

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 61.82  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  86 EIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDrvPTIKELKSMC 165
Cdd:cd20565    30 EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVTAMFIASKYEEMYP--PEIGDFAFVT 107

                          90       100
                  ....*....|....*....|
gi 2262527191 166 CSLYDDDMFTQMEWHVLQTL 185
Cdd:cd20565   108 DNTYTKHQIRQMEMKILRAL 127
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 59-187 1.80e-11

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 61.93  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  59 LRDD-ILSHMLEMDNQTLPDVESID-IQTEIQWFMRPYLLDFLIEAhTAFQLLPSTLF-LAINLLDRYCSKRVVYKRHYQ 135
Cdd:cd20515    21 LLDDrVLQNLLSLEERYLPSASYFKcVQTEIQPFMRKMVTTWMLEV-CEEQNCEEEVFpLAVNYLDRFLSLVPIRKSQLQ 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2262527191 136 LVGCAALLIAAKYndkKDRVPTIKELKSM----CCSLyddDMFTQMEWHVLQTLGW 187
Cdd:cd20515   100 LLGAVCLFLASKL---KETIPLTAEKLCIytdnSITL---QELLDWELLVLTKLKW 149
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 98-189 1.54e-09

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 55.01  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  98 FLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDRVPTIKEL--KSMC-CSLYDddmF 174
Cdd:cd20526     8 WLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLvrVSKCgCSVAE---V 84

                          90
                  ....*....|....*
gi 2262527191 175 TQMEWHVLQTLGWSI 189
Cdd:cd20526    85 LRMERIILDKLHWDL 99
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 60-187 5.79e-09

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 54.50  E-value: 5.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  60 RDDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRY-CSKRVVYKRHYQLVG 138
Cdd:cd20579    11 RDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFmATQENVVKTRLQLIG 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2262527191 139 CAALLIAAKYNDKKDrvPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGW 187
Cdd:cd20579    91 ISSLFIAAKLEEIYP--PKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 91-185 1.99e-08

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 51.55  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  91 MRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKdrVPTIKELKSMCCSLYD 170
Cdd:cd20521     3 MRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKD--ILTIREAAWLTDNTYK 80

                          90
                  ....*....|....*
gi 2262527191 171 DDMFTQMEWHVLQTL 185
Cdd:cd20521    81 YEDVVRMMGEIVAAL 95
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 91-187 2.71e-08

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 51.41  E-value: 2.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  91 MRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKdrvP-TIKELKSMCCSLY 169
Cdd:cd20517     5 NRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVK---PiTVSKLTYLSCDCF 81

                          90
                  ....*....|....*...
gi 2262527191 170 DDDMFTQMEWHVLQTLGW 187
Cdd:cd20517    82 TNLELINQEKDILEALKW 99
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 205-294 3.87e-08

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 51.46  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 205 DAYDPEVEHMALYILEIALFHRDFVAKLSSELARAALALSRCILNRPQ--PRHTHWSSQYDS--MTLV-ALSQQLHQPST 279
Cdd:cd20512    13 DDYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRGDwnDNLVHYSGYTESqlIPCAdIMLEYLVKPIK 92

                          90
                  ....*....|....*...
gi 2262527191 280 V---VARKYASAHYSRVS 294
Cdd:cd20512    93 HhdaFFKKYSSKKFLKAS 110
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 59-187 4.57e-08

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 51.90  E-value: 4.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  59 LRDDILSHMLEMDNQTLPDVESID-IQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLV 137
Cdd:cd20573    21 LNDRVLQTMLKAEETCLPSVSYFKcVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLL 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2262527191 138 GCAALLIAAKYndkKDRVPTIKElkSMCcsLYDD-----DMFTQMEWHVLQTLGW 187
Cdd:cd20573   101 GATCMFLASKM---KETIPLTAE--KLC--IYTDnsirpEELLQMELLVLNKLKW 148
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 96-187 1.71e-07

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 48.85  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  96 LDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYK---RHYQLVGCAALLIAAKYndKKDRVPTIKELKSM-CCSLYDD 171
Cdd:cd20543     6 IDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKdkpWMLQLLAVACLSLAAKM--EETDVPLLVDLQVEePKYVFEA 83

                          90
                  ....*....|....*.
gi 2262527191 172 DMFTQMEWHVLQTLGW 187
Cdd:cd20543    84 KTIQRMELLVLSTLEW 99
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 61-187 2.80e-07

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 49.46  E-value: 2.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  61 DDILSHMLEMDNQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYC-SKRVVYKRHYQLVGC 139
Cdd:cd20580    12 KDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMlTQKNINKSMLQLIGI 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2262527191 140 AALLIAAKYNDKkdRVPTIKELKSMCCSLYDDDMFTQMEWHVLQTLGW 187
Cdd:cd20580    92 TSLFIASKLEEI--YPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 59-188 4.19e-07

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 49.22  E-value: 4.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  59 LRDD-ILSHMLEMDNQTLPDVESID-IQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQL 136
Cdd:cd20574    21 LYDDrVLQNLLTIEERYLPQCSYFKcVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQL 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2262527191 137 VGCAALLIAAKYndkKDRVPTIKElksMCCSLYDDDMFTQ--MEWH--VLQTLGWS 188
Cdd:cd20574   101 LGAVCMFLASKL---KETIPLTAE---KLCIYTDNSIKPQelLEWElvVLGKLKWN 150
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 63-187 1.22e-06

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 48.06  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191  63 ILSHMLEMDNQTLPDVESID-IQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAA 141
Cdd:cd20575    26 VLQNLLRLEERYVPRVSYFQcVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVC 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2262527191 142 LLIAAKYndkKDRVPTIKElkSMCcsLYDDDMFTQ---MEWH--VLQTLGW 187
Cdd:cd20575   106 MLLASKL---RETTPLTIE--KLC--IYTDNSISPrqlLDWEilVLGKLKW 149
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 105-187 9.17e-06

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 43.80  E-value: 9.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 105 AFQLLPSTLFLAINLLDRYCSKRVVYKRH-----YQLVgCAALLIAAKYNDkkDRVPTIKELKSMCCslYDDDMFTQMEW 179
Cdd:cd20557    12 RTRLSPSVVLLALVYLERLRRRLPEALLGqegspYRLF-LVALMLASKYLD--DESYSNKSWAEISG--LPVRELNAMER 86


                  ....*...
gi 2262527191 180 HVLQTLGW 187
Cdd:cd20557    87 EFLEALDW 94
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 103-161 1.68e-05

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 43.11  E-value: 1.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2262527191 103 HTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDRVPTIKEL 161
Cdd:cd20523    12 HRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEEDQNIPSAEDL 70
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 208-296 3.55e-05

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 43.06  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 208 DPEVEHMALYILEIALFHRDFVAKLSSELARAALALSRCILNRPQP------RHTHWS-SQ-YDSMTLVAlsqQLHQPS- 278
Cdd:cd20511    17 DKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEwtstleFHTGYSeSQlMECARLMV---RLHSKAg 93

                          90       100
                  ....*....|....*....|..
gi 2262527191 279 ----TVVARKYASAHYSRVSKV 296
Cdd:cd20511    94 tgklTAVYKKYSSSKFGAVALL 115
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 106-187 8.39e-05

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 41.35  E-value: 8.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 106 FQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDKKDRVPTIKELKSMC-CSLYDDDMfTQMEWHVLQT 184
Cdd:cd20583    16 FGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISqYRFTVSDM-MRMEKIILEK 94


                  ...
gi 2262527191 185 LGW 187
Cdd:cd20583    95 LCW 97
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 197-253 2.10e-04

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 39.88  E-value: 2.10e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2262527191  197 FLQHAVLDDAYDPEVEHMALYILEIALFHRDFVAKLSSELARAALALSRCILNRPQP 253
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPW 58
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 208-293 2.30e-04

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 40.29  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 208 DPEVEHMALYILEIALFHRDFVAKLSSELARAALALSRCILNRPqprhtHWS------SQYDS-------MTLVALSQQL 274
Cdd:cd20509    17 DAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEP-----EWTptlehySTYSEedllpivQKMAKLVVKS 91

                          90       100
                  ....*....|....*....|
gi 2262527191 275 HQPS-TVVARKYASAHYSRV 293
Cdd:cd20509    92 QTSKyQAVKNKYSSSKFMRI 111
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 192-290 4.60e-04

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 39.58  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 192 PTVDAFLQHAVLDDAYDPEVEHMALYILEIALFHRDFVAK-LSSELARAALALSRCILNR-PQPRHTHWSSQYDSMTLVA 269
Cdd:cd20505     1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADPYLKyLPSVIAAAAVCLANHTLGNeVWPQKLARSTGYSLEDLLP 80

                          90       100
                  ....*....|....*....|....*....
gi 2262527191 270 LSQQLHQ--------PSTVVARKYASAHY 290
Cdd:cd20505    81 CLRDLHRtflnapssPQQAIREKYKSSKY 109
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 213-299 6.09e-04

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 39.14  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2262527191 213 HMALYILEIALFHRDFVAKLSSELARAALALSRCILNRPQPrhthWSSQYDSMT----------LVALSQQ-LHQPS--- 278
Cdd:cd20522     1 CLASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALP----WPSQLEEFTgfsledllscVLHLHKKcFHEDSpkd 76

                          90       100
                  ....*....|....*....|....*....
gi 2262527191 279 ------TVVARKYASAHYSRVSK--VMEH 299
Cdd:cd20522    77 yrnvslTAVKQRYEDERFLSISKikVMSY 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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