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Conserved domains on  [gi|2307248125|emb|CAG8231308|]
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unnamed protein product [Penicillium salamii]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-303 4.58e-25

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.34  E-value: 4.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  19 NAQDSELPLHESVLHGSIDAVKRHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLS 98
Cdd:COG0666    49 LADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  99 TYSSCDEITeRLLVEEDADVNFVRGRGKfeapsTSLHHaatrldtillrqllavpgidlniyvtghspvsvAAYHGCVNS 178
Cdd:COG0666   128 AYNGNLEIV-KLLLEAGADVNAQDNDGN-----TPLHL---------------------------------AAANGNLEI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 179 VACLLSiEGVDINRRGSID-PPIYRAVAHGHLDVVRLLVQQGARLYInesTIANHDTTLCMAARVRDMEMVRVLLRHdRI 257
Cdd:COG0666   169 VKLLLE-AGADVNARDNDGeTPLHLAAENGHLEIVKLLLEAGADVNA---KDNDGKTALDLAAENGNLEIVKLLLEA-GA 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2307248125 258 DVNLRNRWFEDPLMLAAKGGHSSIVDALVVNPRLTHFSLKRSLDLA 303
Cdd:COG0666   244 DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-303 4.58e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.34  E-value: 4.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  19 NAQDSELPLHESVLHGSIDAVKRHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLS 98
Cdd:COG0666    49 LADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  99 TYSSCDEITeRLLVEEDADVNFVRGRGKfeapsTSLHHaatrldtillrqllavpgidlniyvtghspvsvAAYHGCVNS 178
Cdd:COG0666   128 AYNGNLEIV-KLLLEAGADVNAQDNDGN-----TPLHL---------------------------------AAANGNLEI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 179 VACLLSiEGVDINRRGSID-PPIYRAVAHGHLDVVRLLVQQGARLYInesTIANHDTTLCMAARVRDMEMVRVLLRHdRI 257
Cdd:COG0666   169 VKLLLE-AGADVNARDNDGeTPLHLAAENGHLEIVKLLLEAGADVNA---KDNDGKTALDLAAENGNLEIVKLLLEA-GA 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2307248125 258 DVNLRNRWFEDPLMLAAKGGHSSIVDALVVNPRLTHFSLKRSLDLA 303
Cdd:COG0666   244 DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-119 7.38e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 7.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  27 LHESVLHGSIDAVKrHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHplANVNCKDkDGNTPLWLSTYSSCDEI 106
Cdd:pfam12796   1 LHLAAKNGNLELVK-LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKD-NGRTALHYAARSGHLEI 76

                          90
                  ....*....|...
gi 2307248125 107 TeRLLVEEDADVN 119
Cdd:pfam12796  77 V-KLLLEKGADIN 88
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 25-254 6.99e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.92  E-value: 6.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  25 LPLHESVLHGSIDAVKRHLRQkGLNLDTQDRKGYTPLHL-----AVQGRRLEVVNLILSHPlANVNCKDKDGNTPL-WLS 98
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDN-GADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYG-ANVNAPDNNGITPLlYAI 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  99 TYSSCDEITERLLVEEDADVNFVRGRGKfeapstSLHHAATRLDTILLR--QLLAVPGIDLNIyvtghspvsvaayhgcV 176
Cdd:PHA03100  115 SKKSNSYSIVEYLLDNGANVNIKNSDGE------NLLHLYLESNKIDLKilKLLIDKGVDINA----------------K 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2307248125 177 NSVACLLSIeGVDINRRGSI-DPPIYRAVAHGHLDVVRLLVQQGARlyINESTIaNHDTTLCMAARVRDMEMVRVLLRH 254
Cdd:PHA03100  173 NRVNYLLSY-GVPINIKDVYgFTPLHYAVYNNNPEFVKYLLDLGAN--PNLVNK-YGDTPLHIAILNNNKEIFKLLLNN 247
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 56-86 2.87e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 2.87e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2307248125   56 KGYTPLHLAVQGRRLEVVNLILSHpLANVNC 86
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK-GADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 92-296 6.09e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 6.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  92 NTPLWLSTYSSCDEITERLLVEEDADVnFVRGR-GKfeapsTSLHHAAT--RLD--TILLRqllAVPGIdLNIYVT---- 162
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKCPSCDL-FQRGAlGE-----TALHVAALydNLEaaVVLME---AAPEL-VNEPMTsdly 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 163 -GHSPVSVAAYHGCVNSVACLLSiEGVDINR--------RGSIDPPIYR-------AVAHGHLDVVRLLVQQGARLYiNE 226
Cdd:cd22192    88 qGETALHIAVVNQNLNLVRELIA-RGADVVSpratgtffRPGPKNLIYYgehplsfAACVGNEEIVRLLIEHGADIR-AQ 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2307248125 227 STIAN---HDTTLcMAARVRDMEMVRVLLRHDRIDVN-----LRNRWFEDPLMLAAKGGHSSIVDALVVNPRLTHFSL 296
Cdd:cd22192   166 DSLGNtvlHILVL-QPNKTFACQMYDLILSYDKEDDLqpldlVPNNQGLTPFKLAAKEGNIVMFQHLVQKRRHIQWTY 242
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-303 4.58e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.34  E-value: 4.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  19 NAQDSELPLHESVLHGSIDAVKRHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLS 98
Cdd:COG0666    49 LADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  99 TYSSCDEITeRLLVEEDADVNFVRGRGKfeapsTSLHHaatrldtillrqllavpgidlniyvtghspvsvAAYHGCVNS 178
Cdd:COG0666   128 AYNGNLEIV-KLLLEAGADVNAQDNDGN-----TPLHL---------------------------------AAANGNLEI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 179 VACLLSiEGVDINRRGSID-PPIYRAVAHGHLDVVRLLVQQGARLYInesTIANHDTTLCMAARVRDMEMVRVLLRHdRI 257
Cdd:COG0666   169 VKLLLE-AGADVNARDNDGeTPLHLAAENGHLEIVKLLLEAGADVNA---KDNDGKTALDLAAENGNLEIVKLLLEA-GA 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2307248125 258 DVNLRNRWFEDPLMLAAKGGHSSIVDALVVNPRLTHFSLKRSLDLA 303
Cdd:COG0666   244 DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-231 4.72e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.34  E-value: 4.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  18 RNAQDSELPLHESVLHGSIDAVKRhLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWL 97
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKL-LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  98 STYSSCDEITeRLLVEEDADVNFVRGRGKfeapsTSLHHAATRLDTILLRQLLAVpGIDLNIYVT-GHSPVSVAAYHGCV 176
Cdd:COG0666   160 AAANGNLEIV-KLLLEAGADVNARDNDGE-----TPLHLAAENGHLEIVKLLLEA-GADVNAKDNdGKTALDLAAENGNL 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2307248125 177 NSVACLLSIEGVDINRRGSIDPPIYRAVAHGHLDVVRLLVQQGARLYINESTIAN 231
Cdd:COG0666   233 EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
110-313 4.02e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.08  E-value: 4.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 110 LLVEEDADVNFVRGRGKFEAPSTSLHHAATRLDTILLRQLLAVPGIDLNIYV-TGHSPVSVAAYHGCVNSVACLLSiEGV 188
Cdd:COG0666    33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDdGGNTLLHAAARNGDLEIVKLLLE-AGA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 189 DINRRGSID-PPIYRAVAHGHLDVVRLLVQQGARLYInesTIANHDTTLCMAARVRDMEMVRVLLRHDrIDVNLRNRWFE 267
Cdd:COG0666   112 DVNARDKDGeTPLHLAAYNGNLEIVKLLLEAGADVNA---QDNDGNTPLHLAAANGNLEIVKLLLEAG-ADVNARDNDGE 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2307248125 268 DPLMLAAKGGHSSIVDALV---VNPRLTHFSLKRSLDLARDDYIQRAIR 313
Cdd:COG0666   188 TPLHLAAENGHLEIVKLLLeagADVNAKDNDGKTALDLAAENGNLEIVK 236
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
134-286 1.40e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.06  E-value: 1.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 134 LHHAATRLDTILLRQLLAVPGIDLNIYVTGHSPVSVAAYHGCVNSVACLLSIEGVDINRRGSIDPPIYRAVAHGHLDVVR 213
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2307248125 214 LLVQQGARLyinESTIANHDTTLCMAARVRDMEMVRVLLRHDrIDVNLRNRWFEDPLMLAAKGGHSSIVDALV 286
Cdd:COG0666   105 LLLEAGADV---NARDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173
Ank_2 pfam12796
Ankyrin repeats (3 copies);
27-119 7.38e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 7.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  27 LHESVLHGSIDAVKrHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHplANVNCKDkDGNTPLWLSTYSSCDEI 106
Cdd:pfam12796   1 LHLAAKNGNLELVK-LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKD-NGRTALHYAARSGHLEI 76

                          90
                  ....*....|...
gi 2307248125 107 TeRLLVEEDADVN 119
Cdd:pfam12796  77 V-KLLLEKGADIN 88
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 25-254 6.99e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.92  E-value: 6.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  25 LPLHESVLHGSIDAVKRHLRQkGLNLDTQDRKGYTPLHL-----AVQGRRLEVVNLILSHPlANVNCKDKDGNTPL-WLS 98
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDN-GADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYG-ANVNAPDNNGITPLlYAI 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  99 TYSSCDEITERLLVEEDADVNFVRGRGKfeapstSLHHAATRLDTILLR--QLLAVPGIDLNIyvtghspvsvaayhgcV 176
Cdd:PHA03100  115 SKKSNSYSIVEYLLDNGANVNIKNSDGE------NLLHLYLESNKIDLKilKLLIDKGVDINA----------------K 172

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2307248125 177 NSVACLLSIeGVDINRRGSI-DPPIYRAVAHGHLDVVRLLVQQGARlyINESTIaNHDTTLCMAARVRDMEMVRVLLRH 254
Cdd:PHA03100  173 NRVNYLLSY-GVPINIKDVYgFTPLHYAVYNNNPEFVKYLLDLGAN--PNLVNK-YGDTPLHIAILNNNKEIFKLLLNN 247
Ank_2 pfam12796
Ankyrin repeats (3 copies);
200-286 1.32e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 200 IYRAVAHGHLDVVRLLVQQGARLYINEstiANHDTTLCMAARVRDMEMVRVLLRHDRIDVNLRNRwfeDPLMLAAKGGHS 279
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQD---KNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGR---TALHYAARSGHL 74


                  ....*..
gi 2307248125 280 SIVDALV 286
Cdd:pfam12796  75 EIVKLLL 81
PHA03095 PHA03095
ankyrin-like protein; Provisional
 25-253 7.97e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.65  E-value: 7.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  25 LPLHESVLHGSIDAVKRHLRQKGLNLDTQDRKGYTPLH--LAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLSTYSS 102
Cdd:PHA03095   85 TPLHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKG-ADVNALDLYGMTPLAVLLKSR 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 103 -CDEITERLLVEEDADVNFVRGRGKfeapsTSLHHAA--TRLDTILLRQLLAVPGIDLNIYVTGHSPVSVAAYHG-CVNS 178
Cdd:PHA03095  164 nANVELLRLLIDAGADVYAVDDRFR-----SLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSsCKRS 238

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2307248125 179 VACLLSIEGVDINRRGSID-PPIYRAVAHGHLDVVRLLVQQGARLyinesTIANHDTTLCMAARVR--DMEMVRVLLR 253
Cdd:PHA03095  239 LVLPLLIAGISINARNRYGqTPLHYAAVFNNPRACRRLIALGADI-----NAVSSDGNTPLSLMVRnnNGRAVRAALA 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
134-225 1.71e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.27  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 134 LHHAATRLDTILLRQLLAvPGIDLNIY-VTGHSPVSVAAYHGCVNSVACLLsiEGVDINRRGSIDPPIYRAVAHGHLDVV 212
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE-NGADANLQdKNGRTALHLAAKNGHLEIVKLLL--EHADVNLKDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|...
gi 2307248125 213 RLLVQQGARLYIN 225
Cdd:pfam12796  78 KLLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
19-88 1.03e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.96  E-value: 1.03e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  19 NAQDSELPLHESVLHGSIDAVKRHLRQKGLNLDTQdrkGYTPLHLAVQGRRLEVVNLILSHPlANVNCKD 88
Cdd:pfam12796  26 QDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN---GRTALHYAARSGHLEIVKLLLEKG-ADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 19-238 1.14e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.07  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  19 NAQDSELPLHESVLHGSIDAVKRHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLS 98
Cdd:PHA02875   64 KYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARG-ADPDIPNTDKFSPLHLA 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  99 TYSSCDEITErLLVEEDADVNFVRGRGkfeapSTSLHHAATRLDTILLRQLLAvPGIDLNiYVTGHSPVSVAAYhgcvns 178
Cdd:PHA02875  143 VMMGDIKGIE-LLIDHKACLDIEDCCG-----CTPLIIAMAKGDIAICKMLLD-SGANID-YFGKNGCVAALCY------ 208

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 179 vacllsiegvdinrrgsidppiyrAVAHGHLDVVRLLVQQGARLYINESTIANHDTTLCM 238
Cdd:PHA02875  209 ------------------------AIENNKIDIVRLFIKRGADCNIMFMIEGEECTILDM 244
PHA03095 PHA03095
ankyrin-like protein; Provisional
 26-275 1.38e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 52.72  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  26 PLHeSVLHGSIDAVKRHLR---QKGLNLDTQDRKGYTPLHLAVQ-GRRLEVVNLILSHPlANVNCKDKDGNTPLwlSTYS 101
Cdd:PHA03095   50 PLH-LYLHYSSEKVKDIVRlllEAGADVNAPERCGFTPLHLYLYnATTLDVIKLLIKAG-ADVNAKDKVGRTPL--HVYL 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 102 SCDEITE---RLLVEEDADVNFVRGRGKfeapsTSLHhaatrldtILLRQllavPGIDLNIyvtghspVSVAAYHGCvns 178
Cdd:PHA03095  126 SGFNINPkviRLLLRKGADVNALDLYGM-----TPLA--------VLLKS----RNANVEL-------LRLLIDAGA--- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 179 vacllSIEGVDINRRGSIdppiyravaHGHLD-------VVRLLVQQGARLYINESTIANHDTTLCMAARVRDMEMVRVL 251
Cdd:PHA03095  179 -----DVYAVDDRFRSLL---------HHHLQsfkprarIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPLL 244

                         250       260
                  ....*....|....*....|....
gi 2307248125 252 LRHdrIDVNLRNRWFEDPLMLAAK 275
Cdd:PHA03095  245 IAG--ISINARNRYGQTPLHYAAV 266
Ank_2 pfam12796
Ankyrin repeats (3 copies);
169-263 1.74e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.57  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 169 VAAYHGCVNSVACLLSiEGVDINRRGSIDP-PIYRAVAHGHLDVVRLLVQQGArlyINESTiaNHDTTLCMAARVRDMEM 247
Cdd:pfam12796   3 LAAKNGNLELVKLLLE-NGADANLQDKNGRtALHLAAKNGHLEIVKLLLEHAD---VNLKD--NGRTALHYAARSGHLEI 76

                          90
                  ....*....|....*.
gi 2307248125 248 VRVLLRHDrIDVNLRN 263
Cdd:pfam12796  77 VKLLLEKG-ADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 47-231 1.75e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.27  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  47 GLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLSTYSSCDEITeRLLVEEDADVNFVRGRGK 126
Cdd:PHA02874  114 GIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYG-ADVNIEDDNGCYPIHIAIKHNFFDII-KLLLEKGAYANVKDNNGE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 127 feapsTSLHHAATRLDTILLRQLLAVPGIDLNIYVTGHSPVSVAAYHGcvNSVACLL----SIEGVDINrrGSIdpPIYR 202
Cdd:PHA02874  192 -----SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--RSAIELLinnaSINDQDID--GST--PLHH 260

                         170       180       190
                  ....*....|....*....|....*....|
gi 2307248125 203 AVAHG-HLDVVRLLVQQGARLYINESTIAN 231
Cdd:PHA02874  261 AINPPcDIDIIDILLYHKADISIKDNKGEN 290
Ank_5 pfam13857
Ankyrin repeats (many copies);
43-95 2.66e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 46.96  E-value: 2.66e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2307248125  43 LRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPL 95
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTAL 53
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
144-286 2.86e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.11  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 144 ILLRQLLAVPGIDLNIYVTGHSPVSVAAYHGCVNSVACLLSIEGVDINRRGSIDPPIYRAVAHGHLDVVRLLVQQGArly 223
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA--- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2307248125 224 INESTIANHDTTLCMAARVRDMEMVRVLLRHDrIDVNLRNRWFEDPLMLAAKGGHSSIVDALV 286
Cdd:COG0666    79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLL 140
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 36-122 3.40e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.59  E-value: 3.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  36 IDAVKRHLRqKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILsHPLANVNCKDKDGNTPLWLSTYsSCDEITERLLVEED 115
Cdd:PHA03100  172 KNRVNYLLS-YGVPINIKDVYGFTPLHYAVYNNNPEFVKYLL-DLGANPNLVNKYGDTPLHIAIL-NNNKEIFKLLLNNG 248


                  ....*..
gi 2307248125 116 ADVNFVR 122
Cdd:PHA03100  249 PSIKTII 255
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 25-315 4.76e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 4.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  25 LPLHESVLHGSIDAVKRhLRQKGLNLDTQDRKGYTPLHLAVQgrrlEVVNLILSHPLANVNcKDKDGNTPLWLST--YSS 102
Cdd:PHA02878   39 IPLHQAVEARNLDVVKS-LLTRGHNVNQPDHRDLTPLHIICK----EPNKLGMKEMIRSIN-KCSVFYTLVAIKDafNNR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 103 CDEITERLLV-----EEDADVNFVRGRGKFEApstslhhaatrLDTILLRQLLAVpGIDLNIYV--TGHSPVSVAAYHGC 175
Cdd:PHA02878  113 NVEIFKIILTnryknIQTIDLVYIDKKSKDDI-----------IEAEITKLLLSY-GADINMKDrhKGNTALHYATENKD 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 176 VNsVACLLSIEGVDINRRGSID-PPIYRAVAHGHLDVVRLLVQQGArlYINESTIANHDTTLCMAARVRDMEMVRVLLRH 254
Cdd:PHA02878  181 QR-LTELLLSYGANVNIPDKTNnSPLHHAVKHYNKPIVHILLENGA--STDARDKCGNTPLHISVGYCKDYDILKLLLEH 257

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2307248125 255 DrIDVNLRNRwfedplMLAAKGGHSSIVDALVVNPRLTHFSLKRSLDLARDDYIQRAIRTR 315
Cdd:PHA02878  258 G-VDVNAKSY------ILGLTALHSSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQY 311
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 2-119 6.32e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.57  E-value: 6.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125   2 KMMFTNGPDseVYLGTRNAQDSelPLHESVLHGSIDaVKRHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPl 81
Cdd:PHA02878  151 KLLLSYGAD--INMKDRHKGNT--ALHYATENKDQR-LTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENG- 224

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2307248125  82 ANVNCKDKDGNTPLWLSTYSSCDEITERLLVEEDADVN 119
Cdd:PHA02878  225 ASTDARDKCGNTPLHISVGYCKDYDILKLLLEHGVDVN 262
Ank_4 pfam13637
Ankyrin repeats (many copies);
26-77 7.96e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 7.96e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2307248125  26 PLHESVLHGSIDAVKRhLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLIL 77
Cdd:pfam13637   4 ALHAAAASGHLELLRL-LLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 32-136 8.01e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 8.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  32 LHGSIDAVK-RHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLSTYSSCDEITERL 110
Cdd:PTZ00322   89 LAASGDAVGaRILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFG-ADPTLLDKDGKTPLELAEENGFREVVQLL 167

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2307248125 111 L----VEEDADVN-----FVRGRGKFEAPSTSLHH 136
Cdd:PTZ00322  168 SrhsqCHFELGANakpdsFTGKPPSLEDSPISSHH 202
Ank_2 pfam12796
Ankyrin repeats (3 copies);
236-291 9.05e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.57  E-value: 9.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2307248125 236 LCMAARVRDMEMVRVLLRHDrIDVNLRNRWFEDPLMLAAKGGHSSIVDALVVNPRL 291
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV 55
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 43-220 1.30e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.78  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  43 LRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLSTYSSCDEIterllveedadVNFVR 122
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTALWNAISAKHHKI-----------FRILY 611

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 123 GRGKFEAPSTS---LHHAATRLDTILLRQLLAvpgIDLNIYVTGHSPVSVaayhgcvnsvacllsiegvdinrrgsidpp 199
Cdd:PLN03192  612 HFASISDPHAAgdlLCTAAKRNDLTAMKELLK---QGLNVDSEDHQGATA------------------------------ 658

                         170       180
                  ....*....|....*....|.
gi 2307248125 200 IYRAVAHGHLDVVRLLVQQGA 220
Cdd:PLN03192  659 LQVAMAEDHVDMVRLLIMNGA 679
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 26-232 2.02e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.21  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  26 PLHESVLHGSIDAVKRHLRQKGLNLDTQDRKGYTPLHL-AVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLSTYSSCD 104
Cdd:PHA02876  276 PLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLmAKNGYDTENIRTLIMLG-ADVNAADRLYITPLHQASTLDRN 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 105 EITERLLVEEDADVNfvrGRGKFEapSTSLHHAATRLDTILLRQLLAVpGIDLNIYVTGHSPVSVAAYHGC--VNSVACL 182
Cdd:PHA02876  355 KDIVITLLELGANVN---ARDYCD--KTPIHYAAVRNNVVIINTLLDY-GADIEALSQKIGTALHFALCGTnpYMSVKTL 428

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2307248125 183 LSiEGVDINRRGS-IDPPIYRAVAHG-HLDVVRLLVQQGARlyINESTIANH 232
Cdd:PHA02876  429 ID-RGANVNSKNKdLSTPLHYACKKNcKLDVIEMLLDNGAD--VNAINIQNQ 477
Ank_4 pfam13637
Ankyrin repeats (many copies);
163-216 5.15e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 5.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2307248125 163 GHSPVSVAAYHGCVNSVAcLLSIEGVDINRR-GSIDPPIYRAVAHGHLDVVRLLV 216
Cdd:pfam13637   1 ELTALHAAAASGHLELLR-LLLEKGADINAVdGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
198-252 1.49e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 1.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2307248125 198 PPIYRAVAHGHLDVVRLLVQQGARLYInesTIANHDTTLCMAARVRDMEMVRVLL 252
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINA---VDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
251-303 1.74e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 1.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2307248125 251 LLRHDRIDVNLRNRWFEDPLMLAAKGGHSSIVDALVVNP---RLTHFSLKRSLDLA 303
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGvdlNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
232-286 1.74e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 1.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2307248125 232 HDTTLCMAARVRDMEMVRVLLRHdRIDVNLRNRWFEDPLMLAAKGGHSSIVDALV 286
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 137-288 1.96e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.32  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 137 AATRLDTILLRQLLAVpGIDLNIY-VTGHSPVSVAAYHGCVNSVACLLSiEGVDIN-RRGSIDPPIYRAVAHGHLDVVRL 214
Cdd:PLN03192  532 VASTGNAALLEELLKA-KLDPDIGdSKGRTPLHIAASKGYEDCVLVLLK-HACNVHiRDANGNTALWNAISAKHHKIFRI 609

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2307248125 215 LVQQGArlyINESTIANhdTTLCMAARVRDMEMVRVLLRHDrIDVNLRNRWFEDPLMLAAKGGHSSIVDALVVN 288
Cdd:PLN03192  610 LYHFAS---ISDPHAAG--DLLCTAAKRNDLTAMKELLKQG-LNVDSEDHQGATALQVAMAEDHVDMVRLLIMN 677
PHA03095 PHA03095
ankyrin-like protein; Provisional
 97-264 4.61e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.93  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  97 LSTYSSCDEITERLLVEEDADVNFVRGRGKfeAPSTSLHHAATRLDTILLRQLLAVpGIDLNIYVT-GHSPVSVAAYHGC 175
Cdd:PHA03095   19 LLNASNVTVEEVRRLLAAGADVNFRGEYGK--TPLHLYLHYSSEKVKDIVRLLLEA-GADVNAPERcGFTPLHLYLYNAT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 176 VNSVACLLSIEGVDINRRGSIDppiyRAVAHGHL-------DVVRLLVQQGARlyINESTIANHDTTLCMAARVR-DMEM 247
Cdd:PHA03095   96 TLDVIKLLIKAGADVNAKDKVG----RTPLHVYLsgfninpKVIRLLLRKGAD--VNALDLYGMTPLAVLLKSRNaNVEL 169

                         170
                  ....*....|....*....
gi 2307248125 248 VRVLLRH--DRIDVNLRNR 264
Cdd:PHA03095  170 LRLLIDAgaDVYAVDDRFR 188
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 24-286 8.15e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.13  E-value: 8.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  24 ELPLHESVLHGSIDaVKRHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSH-PLANVNCKDkdgntplwlstyss 102
Cdd:PHA02875    3 QVALCDAILFGELD-IARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHgAIPDVKYPD-------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 103 cdeiterllveedadvnfvrgrgkFEAPstsLHHAATRLDTILLRQLLavpgiDLNIYVtghspvsvaayhgcvNSVacl 182
Cdd:PHA02875   68 ------------------------IESE---LHDAVEEGDVKAVEELL-----DLGKFA---------------DDV--- 97

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 183 lsiegvdINRRGSIdpPIYRAVAHGHLDVVRLLVQQGArlyinESTIANHD--TTLCMAARVRDMEMVRVLLRHdRIDVN 260
Cdd:PHA02875   98 -------FYKDGMT--PLHLATILKKLDIMKLLIARGA-----DPDIPNTDkfSPLHLAVMMGDIKGIELLIDH-KACLD 162

                         250       260
                  ....*....|....*....|....*.
gi 2307248125 261 LRNRWFEDPLMLAAKGGHSSIVDALV 286
Cdd:PHA02875  163 IEDCCGCTPLIIAMAKGDIAICKMLL 188
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 43-286 1.54e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  43 LRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPLANVNCKDKDGNTPLWLSTYSSCDEITERLLVEEDADVNFVR 122
Cdd:PHA02876  259 LYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIMLGADVNAAD 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 123 grgkfEAPSTSLHHAAT--RLDTILLRQLLAVPGIDLNIYVTgHSPVSVAAYHGCVNSVACLLSIeGVDINRRGS-IDPP 199
Cdd:PHA02876  339 -----RLYITPLHQASTldRNKDIVITLLELGANVNARDYCD-KTPIHYAAVRNNVVIINTLLDY-GADIEALSQkIGTA 411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 200 IYRAVAHGH-LDVVRLLVQQGARLyinESTIANHDTTLCMAARVR-DMEMVRVLLRH--DRIDVNLRNRWfedPLMLAAk 275
Cdd:PHA02876  412 LHFALCGTNpYMSVKTLIDRGANV---NSKNKDLSTPLHYACKKNcKLDVIEMLLDNgaDVNAINIQNQY---PLLIAL- 484

                         250
                  ....*....|.
gi 2307248125 276 gGHSSIVDALV 286
Cdd:PHA02876  485 -EYHGIVNILL 494
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 19-127 1.59e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  19 NAQD--SELPLHESVLHGSIdAVKRHLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPLANVNCKDKDGNTPLW 96
Cdd:PHA02876  369 NARDycDKTPIHYAAVRNNV-VIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSVKTLIDRGANVNSKNKDLSTPLH 447

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2307248125  97 LSTYSSCDEITERLLVEEDADVNFVRGRGKF 127
Cdd:PHA02876  448 YACKKNCKLDVIEMLLDNGADVNAINIQNQY 478
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 56-89 1.79e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2307248125  56 KGYTPLHLAV-QGRRLEVVNLILSHPlANVNCKDK 89
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKG-ADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 56-86 2.87e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 2.87e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2307248125   56 KGYTPLHLAVQGRRLEVVNLILSHpLANVNC 86
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK-GADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
57-100 2.89e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 2.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2307248125  57 GYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLSTY 100
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAAS 43
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 26-95 4.05e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 38.79  E-value: 4.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  26 PLHESVLHGSIDAVKRhLRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPL 95
Cdd:PHA02874  160 PIHIAIKHNFFDIIKL-LLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG-NHIMNKCKNGFTPL 227
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 92-296 6.09e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 6.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125  92 NTPLWLSTYSSCDEITERLLVEEDADVnFVRGR-GKfeapsTSLHHAAT--RLD--TILLRqllAVPGIdLNIYVT---- 162
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKCPSCDL-FQRGAlGE-----TALHVAALydNLEaaVVLME---AAPEL-VNEPMTsdly 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2307248125 163 -GHSPVSVAAYHGCVNSVACLLSiEGVDINR--------RGSIDPPIYR-------AVAHGHLDVVRLLVQQGARLYiNE 226
Cdd:cd22192    88 qGETALHIAVVNQNLNLVRELIA-RGADVVSpratgtffRPGPKNLIYYgehplsfAACVGNEEIVRLLIEHGADIR-AQ 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2307248125 227 STIAN---HDTTLcMAARVRDMEMVRVLLRHDRIDVN-----LRNRWFEDPLMLAAKGGHSSIVDALVVNPRLTHFSL 296
Cdd:cd22192   166 DSLGNtvlHILVL-QPNKTFACQMYDLILSYDKEDDLqpldlVPNNQGLTPFKLAAKEGNIVMFQHLVQKRRHIQWTY 242
PHA02946 PHA02946
ankyin-like protein; Provisional
 43-119 9.44e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 37.73  E-value: 9.44e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2307248125  43 LRQKGLNLDTQDRKGYTPLHLAVQGRRLEVVNLILSHPlANVNCKDKDGNTPLWLSTYSScDEITER--LLVEEDADVN 119
Cdd:PHA02946   58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHG-ADPNACDKQHKTPLYYLSGTD-DEVIERinLLVQYGAKIN 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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