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Conserved domains on  [gi|2059035400|emb|CAG7508781|]
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ribose-phosphate pyrophosphokinase [Streptococcus pneumoniae]

Protein Classification

ribose-phosphate pyrophosphokinase( domain architecture ID 11479809)

ribose-phosphate pyrophosphokinase catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form the the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 1-319 0e+00

ribose-phosphate pyrophosphokinase; Provisional


:

Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 648.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   1 MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDAC 80
Cdd:PRK02458    4 RYADKQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDAC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  81 VRASAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCD 160
Cdd:PRK02458   84 KRASANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 161 KGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKAILIDDILNTGRTFSEASKIVER 240
Cdd:PRK02458  164 KGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREEGYIIGDVAGKKAILIDDILNTGKTFAEAAKIVER 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2059035400 241 EGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK 319
Cdd:PRK02458  244 EGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKERVPKNVTYLSASELIADAIIRIHERKPLSPLFAYNKKG 322
 
Name Accession Description Interval E-value
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 1-319 0e+00

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 648.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   1 MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDAC 80
Cdd:PRK02458    4 RYADKQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDAC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  81 VRASAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCD 160
Cdd:PRK02458   84 KRASANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 161 KGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKAILIDDILNTGRTFSEASKIVER 240
Cdd:PRK02458  164 KGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREEGYIIGDVAGKKAILIDDILNTGKTFAEAAKIVER 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2059035400 241 EGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK 319
Cdd:PRK02458  244 EGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKERVPKNVTYLSASELIADAIIRIHERKPLSPLFAYNKKG 322
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 4-313 1.12e-162

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 455.29  E-value: 1.12e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   4 RKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRA 83
Cdd:COG0462     1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  84 SAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKGL 163
Cdd:COG0462    81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 164 lgSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEG-YIIGDVEGKKAILIDDILNTGRTFSEASKIVEREG 242
Cdd:COG0462   161 --EDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVmNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2059035400 243 ATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVA-TKEKTPKNVCYITASELIGDAIVRIHERKPVSPLF 313
Cdd:COG0462   239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPlPEEKRCDKIKVLSVAPLLAEAIRRIHEGESVSSLF 310
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 7-313 1.62e-122

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 353.51  E-value: 1.62e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   7 MKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYII-QSTSFPVNNHLMELLIMVDACVRASA 85
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  86 HSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYcdKGLLG 165
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYL--KKKIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 166 SDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRN--EGYIIGDVEGKKAILIDDILNTGRTFSEASKIVEREGA 243
Cdd:TIGR01251 159 DNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRISATNEveVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 244 TEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKEKTPKnVCYITASELIGDAIVRIHERKPVSPLF 313
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHEKHKPK-VSVISVAPLIAEAIRRIHNNESVSSLF 307
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 7-123 3.15e-71

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 216.13  E-value: 3.15e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   7 MKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAH 86
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2059035400  87 SINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAG 123
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 151-276 7.33e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 86.30  E-value: 7.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 151 VPLFAKHYcdKGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRN-------EGYIIGDVEGKKAILIDD 223
Cdd:cd06223     2 GRLLAEEI--REDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTpsepyglELPLGGDVKGKRVLLVDD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2059035400 224 ILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDntNIKEILVTDS 276
Cdd:cd06223    80 VIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELAS--PGDPVYSLFT 130
 
Name Accession Description Interval E-value
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 1-319 0e+00

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 648.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   1 MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDAC 80
Cdd:PRK02458    4 RYADKQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDAC 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  81 VRASAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCD 160
Cdd:PRK02458   84 KRASANTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 161 KGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKAILIDDILNTGRTFSEASKIVER 240
Cdd:PRK02458  164 KGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREEGYIIGDVAGKKAILIDDILNTGKTFAEAAKIVER 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2059035400 241 EGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK 319
Cdd:PRK02458  244 EGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKERVPKNVTYLSASELIADAIIRIHERKPLSPLFAYNKKG 322
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 4-313 1.12e-162

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 455.29  E-value: 1.12e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   4 RKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRA 83
Cdd:COG0462     1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  84 SAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKGL 163
Cdd:COG0462    81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 164 lgSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEG-YIIGDVEGKKAILIDDILNTGRTFSEASKIVEREG 242
Cdd:COG0462   161 --EDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVmNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2059035400 243 ATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVA-TKEKTPKNVCYITASELIGDAIVRIHERKPVSPLF 313
Cdd:COG0462   239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPlPEEKRCDKIKVLSVAPLLAEAIRRIHEGESVSSLF 310
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
7-314 1.26e-149

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 422.22  E-value: 1.26e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   7 MKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAH 86
Cdd:PRK01259    1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  87 SINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKGLlgS 166
Cdd:PRK01259   81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNL--E 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 167 DVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDAtrNEG---YIIGDVEGKKAILIDDILNTGRTFSEASKIVEREGA 243
Cdd:PRK01259  159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRA--NVSevmNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGA 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2059035400 244 TEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKE--KTPKNVCYITASELIGDAIVRIHERKPVSPLFA 314
Cdd:PRK01259  237 KSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEeaKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
6-317 6.62e-143

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 405.72  E-value: 6.62e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   6 NMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASA 85
Cdd:PRK02269    5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  86 HSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKGLLG 165
Cdd:PRK02269   85 ESINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLVG 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 166 SDVVVVSPKNSGVKRARSLAEYLDAPIAIID--YPQDDATRNEGY-IIGDVEGKKAILIDDILNTGRTFSEASKIVEREG 242
Cdd:PRK02269  165 DDVVVVSPDHGGVTRARKLAQFLKTPIAIIDkrRSVDKMNTSEVMnIIGNVKGKKCILIDDMIDTAGTICHAADALAEAG 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2059035400 243 ATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSV-ATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNK 317
Cdd:PRK02269  245 ATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIyLPEERLIDKIEQISIADLLGEAIIRIHEKRPLSPLFEMGK 320
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 7-313 1.62e-122

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 353.51  E-value: 1.62e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   7 MKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYII-QSTSFPVNNHLMELLIMVDACVRASA 85
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  86 HSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYcdKGLLG 165
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYL--KKKIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 166 SDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRN--EGYIIGDVEGKKAILIDDILNTGRTFSEASKIVEREGA 243
Cdd:TIGR01251 159 DNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRISATNEveVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 244 TEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKEKTPKnVCYITASELIGDAIVRIHERKPVSPLF 313
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHEKHKPK-VSVISVAPLIAEAIRRIHNNESVSSLF 307
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 1-313 6.09e-108

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 317.45  E-value: 6.09e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   1 MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDAC 80
Cdd:PRK02812   16 LSDNNRLRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDAC 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  81 VRASAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCD 160
Cdd:PRK02812   96 RRASARQITAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLAS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 161 KGLlgSDVVVVSPKNSGVKRARSLAEYL-DAPIAIIDypqddaTRNEGY-------IIGDVEGKKAILIDDILNTGRTFS 232
Cdd:PRK02812  176 KNL--EDIVVVSPDVGGVARARAFAKKLnDAPLAIID------KRRQAHnvaevlnVIGDVKGKTAILVDDMIDTGGTIC 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 233 EASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDS--VATKEKTPKnVCYITASELIGDAIVRIHERKPVS 310
Cdd:PRK02812  248 EGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTipVPEERRFPQ-LKVLSVANMLGEAIWRIHEESSVS 326


                  ...
gi 2059035400 311 PLF 313
Cdd:PRK02812  327 SMF 329
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 17-313 1.22e-104

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 308.16  E-value: 1.22e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  17 EIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFG 96
Cdd:PLN02369    2 ALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYFG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  97 YARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKGLLGSDVVVVSPKNS 176
Cdd:PLN02369   82 YARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDVG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 177 GVKRARSLAEYL-DAPIAIIDYPQDDATRNEGY-IIGDVEGKKAILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGL 254
Cdd:PLN02369  162 GVARARAFAKKLsDAPLAIVDKRRQGHNVAEVMnLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAV 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2059035400 255 FVEGAAELLDNTNIKEILVTDSVATKEKT--PKnVCYITASELIGDAIVRIHERKPVSPLF 313
Cdd:PLN02369  242 FSPPAIERLSSGLFQEVIVTNTIPVSEKNyfPQ-LTVLSVANLLGETIWRVHDDCSVSSIF 301
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
19-313 2.47e-91

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 274.13  E-value: 2.47e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  19 AQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYA 98
Cdd:PRK03092    2 AEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPYA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  99 RQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKgLLGSDVVVVSPKNSGV 178
Cdd:PRK03092   82 RQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDK-YDLDNVTVVSPDAGRV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 179 KRARSLAEYL-DAPIAIIDYPQD-----DATRNEgyIIGDVEGKKAILIDDILNTGRTFSEASKIVEREGATEIYAVSSH 252
Cdd:PRK03092  161 RVAEQWADRLgGAPLAFIHKTRDptvpnQVVANR--VVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATH 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2059035400 253 GLFVEGAAELLDNTNIKEILVTDSV-ATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLF 313
Cdd:PRK03092  239 GVLSGPAAERLKNCGAREVVVTDTLpIPEEKRFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
1-313 5.54e-87

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 263.71  E-value: 5.54e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   1 MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDAC 80
Cdd:PRK04923    1 MQDQRNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  81 VRASAHSINVVLPYFGYARQD-RIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLfakhyc 159
Cdd:PRK04923   81 KRASAASVTAVIPYFGYSRQDrRMRSSRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPL------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 160 dkgLLGS--------DVVVVSPKNSGVKRARSLAEYL-DAPIAIIDYPQDDAtrNEGY---IIGDVEGKKAILIDDILNT 227
Cdd:PRK04923  155 ---LLADiwraygtdNLIVVSPDVGGVVRARAVAKRLdDADLAIIDKRRPRA--NVATvmnIIGDVQGKTCVLVDDLVDT 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 228 GRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKE--KTPKNVCYITASELIGDAIVRIHE 305
Cdd:PRK04923  230 AGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEaaRACAKIRQLSVAELLAETIRRIAF 309


                  ....*...
gi 2059035400 306 RKPVSPLF 313
Cdd:PRK04923  310 GESVSSLY 317
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 3-277 5.61e-80

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 246.37  E-value: 5.61e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   3 DRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVR 82
Cdd:PRK00553    6 DKSNHVIFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  83 ASAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDkg 162
Cdd:PRK00553   86 GSAKSITAILPYYGYARQDRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLSRVLE-- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 163 LLG-SDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGY-IIGDVEGKKAILIDDILNTGRTFSEASKIVER 240
Cdd:PRK00553  164 LLGkKDLVVVSPDYGGVKRARLIAESLELPLAIIDKRRPKHNVAESInVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKK 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2059035400 241 EGATEIYAVSSHGLFVEGAAELLDNT----NIKEILVTDSV 277
Cdd:PRK00553  244 QKAKKVCVMATHGLFNKNAIQLFDEAfkkkLIDKLFVSNSI 284
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 6-313 5.65e-79

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 247.09  E-value: 5.65e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   6 NMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASA 85
Cdd:PTZ00145  119 NAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRASA 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  86 HSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFD--IPVDNLFTVPLFAKHYCDKGL 163
Cdd:PTZ00145  199 KKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTKKDL 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 164 LGSdvVVVSPKNSGVKRARSLAEYL------DAPIAIIDYPQDDATRNEGY-IIGDVEGKKAILIDDILNTGRTFSEASK 236
Cdd:PTZ00145  279 YKP--VIVSPDAGGVYRARKFQDGLnhrgisDCGIAMLIKQRTKPNEIEKMdLVGNVYDSDVIIVDDMIDTSGTLCEAAK 356

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2059035400 237 IVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKE--KTPKNVCYITASELIGDAIVRIHERKPVSPLF 313
Cdd:PTZ00145  357 QLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKniDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 7-123 3.15e-71

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 216.13  E-value: 3.15e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   7 MKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAH 86
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2059035400  87 SINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAG 123
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 8-300 8.54e-62

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 197.83  E-value: 8.54e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   8 KLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTsFPVNNHLMELLIMVDACVRASAHS 87
Cdd:PRK00934    1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTT-YPQDENLVELLLLIDALRDEGAKS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  88 INVVLPYFGYARQDRIACPREPLTAKLVANMLvKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKglLGsD 167
Cdd:PRK00934   80 ITLVIPYLGYARQDKRFKPGEPISARAIAKII-SAYYDRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDK--LD-D 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 168 VVVVSPKNSGVKRARSLAEYLDapiaiIDYPQDDATRNEGYIIG------DVEGKKAILIDDILNTGRTFSEASKIVERE 241
Cdd:PRK00934  156 PLVLAPDKGALELAKEAAEILG-----CEYDYLEKTRISPTEVEiapknlDVKGKDVLIVDDIISTGGTMATAIKILKEQ 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2059035400 242 GATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKektpknVCYITASELIGDAI 300
Cdd:PRK00934  231 GAKKVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLESE------VSKISVAPLIADLL 283
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 38-312 7.19e-44

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 154.34  E-value: 7.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  38 FSDGEIQVNIEESVRGYDVYIIQSTS--------------FPVNNHLMELLIMVDACvRASAHSINVVLPYFGYARQDRi 103
Cdd:PRK06827   62 FSNGEAKGEILESVRGKDIYILQDVGnysvtynmfgeknhMSPDDHFQDLKRTIDAI-RGKARRITVIMPFLYESRQHK- 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 104 ACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIP-VDNLFT----VPLFAKHYCDKGLLGSDVVVVSPKNSGV 178
Cdd:PRK06827  140 RKGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLMgFENLYPsyqiIKALLKNEKDLEIDKDHLMVISPDTGAM 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 179 KRARSLAEYLDAPIAIIdYPQDDATR---------NEGYIIGDVEGKKAILIDDILNTGRTFSEASKIVEREGATEIYAV 249
Cdd:PRK06827  220 DRAKYYASVLGVDLGLF-YKRRDYSRvvngrnpivAHEFLGRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKIIVA 298

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2059035400 250 SSHGLFVEGAA---ELLDNTNIKEILVTDSVATKEKTPKNVCYITA--SELIGDAIVRIHERKPVSPL 312
Cdd:PRK06827  299 ATFGFFTNGLEkfdKAYEEGYFDRIIGTNLVYHPEELLSKPWYIEVdmSKLIARIIDALNHDVSLSKL 366
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
9-302 3.65e-40

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 142.38  E-value: 3.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   9 LFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPvNNHLMELLIMVDACVRASAHSI 88
Cdd:PRK07199    5 LLALPGNEAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLDRP-DEKLLPLLFAAEAARELGARRV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  89 NVVLPYFGYARQDRIACPREPLTAKLVANMLVkAGVDRILTLD--LHAV-QVQGFFDIPVDNLFTVPLFAKhycdkgLLG 165
Cdd:PRK07199   84 GLVAPYLAYMRQDIAFHPGEAISQRHFARLLS-GSFDRLVTVDphLHRYpSLSEVYPIPAVVLSAAPAIAA------WIR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 166 SDV---VVVSPKNSGVKRARSLAEYLDAPIAI------------IDYPqdDATRnegyiigdVEGKKAILIDDILNTGRT 230
Cdd:PRK07199  157 AHVprpLLIGPDEESEQWVAAVAERAGAPHAVlrktrhgdrdveISLP--DAAP--------WAGRTPVLVDDIVSTGRT 226

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2059035400 231 FSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVAtkekTPKNVcyITASELIGDAIVR 302
Cdd:PRK07199  227 LIEAARQLRAAGAASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVP----HPSNA--ISLAPLLAEALRR 292
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 151-276 7.33e-21

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 86.30  E-value: 7.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 151 VPLFAKHYcdKGLLGSDVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRN-------EGYIIGDVEGKKAILIDD 223
Cdd:cd06223     2 GRLLAEEI--REDLLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTpsepyglELPLGGDVKGKRVLLVDD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2059035400 224 ILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDntNIKEILVTDS 276
Cdd:cd06223    80 VIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELAS--PGDPVYSLFT 130
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 170-313 4.27e-19

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 83.33  E-value: 4.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 170 VVSPKNSGV-KRARSLAEYLDAPIAIIDYPQDDATRNEG-------------------------------YIIGDVEGKK 217
Cdd:pfam14572   6 VIVARSPGSaKRATSFAERLRLGIAVIHGEQKEAESDEVdgrqspppyrsrtvsrslglpeiipkekppmTVVGDVGGRI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 218 AILIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSV---ATKEKTPKnVCYITASE 294
Cdd:pfam14572  86 AIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIpheIQKMQCHK-IKTIDISQ 164

                         170
                  ....*....|....*....
gi 2059035400 295 LIGDAIVRIHERKPVSPLF 313
Cdd:pfam14572 165 LIAEAIRRIHNGESMSYLF 183
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 1-255 3.13e-14

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 72.03  E-value: 3.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400   1 MSDRKNMKLFALNSNQEIAQKIAQAVG-VPLGKLSSRQFSDG--EIQVNIEESVRGYDVYIIqsTSFPVNNHLMELLIMV 77
Cdd:PLN02297   11 KKNKKQVHLFYCEETEELARKIAAESDaIELGSINWRKFPDGfpNLFINNAHGIRGQHVAFL--ASFSSPAVIFEQLSVI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400  78 DACVRASAHSINVVLPYFGYARQDRIACPREPLTAKLVANML-----VKAGVDRILTLDLHAVQVQGFFDIPVDNLFT-- 150
Cdd:PLN02297   89 YALPKLFVASFTLVLPFFPTGTSERVEREGDVATAFTLARILsnipiSRGGPTSLVIFDIHALQERFYFGDNVLPCFEsg 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 151 VPLFAKHYcdKGLLGSDVVVVS-PKNSGVKRARSLAEyldapiaiiDYPQDDATR-NEG--YII----GDVEGKKAILID 222
Cdd:PLN02297  169 IPLLKKRL--QQLPDSDNIVIAfPDDGAWKRFHKQFE---------HFPMVVCTKvREGdkRIVrikeGNPAGRHVVIVD 237

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2059035400 223 DILNTGRTFSEASKIVEREGATEIYAVSSHGLF 255
Cdd:PLN02297  238 DLVQSGGTLIECQKVLAAHGAAKVSAYVTHGVF 270
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 153-246 5.59e-08

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 51.21  E-value: 5.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 153 LFAKHYCDKGllGSDVVVVSPKNSGVKRARSLAEYLDAPIAIID---YpQDDATRNEGYI--IGDVEGKKAILIDDILNT 227
Cdd:pfam00156  18 LAAQINEDYG--GKPDVVVGILRGGLPFAGILARRLDVPLAFVRkvsY-NPDTSEVMKTSsaLPDLKGKTVLIVDDILDT 94

                          90
                  ....*....|....*....
gi 2059035400 228 GRTFSEASKIVEREGATEI 246
Cdd:pfam00156  95 GGTLLKVLELLKNVGPKEV 113
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 181-246 2.53e-06

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 46.38  E-value: 2.53e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2059035400 181 ARSLAEYLDAP----IAIIDYPQDDATRNE----GYIIGDVEGKKAILIDDILNTGRTFSEASKIVEREGATEI 246
Cdd:COG2236    46 ARILADALGVPdlasIRVSSYTGTAKRLEEpvvkGPLDEDLAGKRVLIVDDVADTGRTLEAVRDLLKEAGPAEV 119
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 169-271 2.14e-05

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 44.47  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 169 VVVSPKNSGVKRARSLAEYLDAPIAII---DYPQDDATRNEGYI---IGDVEGKKAILIDDILNTGRTFSEASKIVEREG 242
Cdd:PRK02277   88 VVVGIAKSGVPLATLVADELGKDLAIYhpkKWDHGEGEKKTGSFsrnFASVEGKRCVIVDDVITSGTTMKETIEYLKEHG 167

                          90       100
                  ....*....|....*....|....*....
gi 2059035400 243 ATEIYAVSshglfvegaaeLLDNTNIKEI 271
Cdd:PRK02277  168 GKPVAVVV-----------LIDKSGIDEI 185
ComFC COG1040
DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General ...
 211-249 2.79e-05

DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General function prediction only];


Pssm-ID: 440662 [Multi-domain]  Cd Length: 196  Bit Score: 44.04  E-value: 2.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2059035400 211 GDVEGKKAILIDDILNTGRTFSEASKIVEREGATEIYAV 249
Cdd:COG1040   151 ARLAGKHVLLVDDVLTTGATLAEAARALKAAGAARVDVL 189
PRK05205 PRK05205
bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;
166-230 1.21e-03

bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR;


Pssm-ID: 235365  Cd Length: 176  Bit Score: 38.95  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 166 SDVVVVSPKNSGVKRARSLAEYL------DAPIAIID---YpQDDATRNEGY-------IIGDVEGKKAILIDDILNTGR 229
Cdd:PRK05205   31 DNLVLVGIKTRGVWLAERLAERLeqlegvDVPVGELDitlY-RDDLTKKGLHpqvkptdIPFDIEGKRVILVDDVLYTGR 109


                  .
gi 2059035400 230 T 230
Cdd:PRK05205  110 T 110
PyrR COG2065
Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide ...
 166-230 1.28e-03

Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441668  Cd Length: 178  Bit Score: 38.88  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2059035400 166 SDVVVVSPKNSGVKRARSLAEYL------DAPIAIID---YpQDDATR-------NEGYIIGDVEGKKAILIDDILNTGR 229
Cdd:COG2065    31 EDLVLVGIQTRGVPLAERLAERIeeiegvKVPVGSLDitlY-RDDLRRrpprpvvNETEIPFDIDGKTVVLVDDVLYTGR 109


                  .
gi 2059035400 230 T 230
Cdd:COG2065   110 T 110
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 212-247 2.47e-03

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 38.08  E-value: 2.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2059035400 212 DVEGKKAILIDDILNTGRTFSEASKIVEREGATEIY 247
Cdd:COG0634    88 DIEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVK 123
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 207-269 5.59e-03

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 37.44  E-value: 5.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2059035400 207 GYIIGDV-EGKKAILIDDILNTGRTFSEASKIVEREGATEIYAVSshglFV---EGAAELLDNTNIK 269
Cdd:COG0461   103 GQIEGGLlPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAV----IVdreEGAAENLEEAGVP 165
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 212-246 5.97e-03

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 37.32  E-value: 5.97e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2059035400 212 DVEGKKAILIDDILNTGRTFSEASKIVEREGATEI 246
Cdd:PLN02238   94 DVKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASV 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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