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Conserved domains on  [gi|12055542|emb|CAC20899|]
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uncoupling protein UCP-4, isoform b [Rattus norvegicus]

Protein Classification

solute carrier family 25 protein( domain architecture ID 10445172)

solute carrier 25 family (SLC25) protein which transfers molecules across the membranes of organelles, usually mitochondria

Gene Ontology:  GO:0016020|GO:1990542
TCDB:  2.A.29

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
122-218 6.01e-25

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 96.57  E-value: 6.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542   122 EHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRrlegKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAAL 201
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGS----GKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAP 76
                          90
                  ....*....|....*..
gi 12055542   202 VNMGDLTTYDTVKHYLV 218
Cdd:pfam00153  77 AAAIYFGTYETLKRLLL 93
Mito_carr pfam00153
Mitochondrial carrier protein;
20-119 4.08e-20

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 83.86  E-value: 4.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542    20 SKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALAKlgdgamesapYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVV 99
Cdd:pfam00153   7 ASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSK----------GRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAP 76
                          90       100
                  ....*....|....*....|
gi 12055542   100 YSGGRMVTYEHLREVVFGKS 119
Cdd:pfam00153  77 AAAIYFGTYETLKRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
224-299 5.49e-16

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 72.30  E-value: 5.49e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12055542   224 EDNIATHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRgllYKSSTDCVIQAVQGEGFLSLYKGFLPSWLRM 299
Cdd:pfam00153   2 ELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSK---GRGILDCFKKIYKEEGIRGLYKGLLPNLLRV 74
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
122-218 6.01e-25

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 96.57  E-value: 6.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542   122 EHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRrlegKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAAL 201
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGS----GKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAP 76
                          90
                  ....*....|....*..
gi 12055542   202 VNMGDLTTYDTVKHYLV 218
Cdd:pfam00153  77 AAAIYFGTYETLKRLLL 93
Mito_carr pfam00153
Mitochondrial carrier protein;
20-119 4.08e-20

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 83.86  E-value: 4.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542    20 SKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALAKlgdgamesapYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVV 99
Cdd:pfam00153   7 ASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSK----------GRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAP 76
                          90       100
                  ....*....|....*....|
gi 12055542   100 YSGGRMVTYEHLREVVFGKS 119
Cdd:pfam00153  77 AAAIYFGTYETLKRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
224-299 5.49e-16

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 72.30  E-value: 5.49e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12055542   224 EDNIATHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRgllYKSSTDCVIQAVQGEGFLSLYKGFLPSWLRM 299
Cdd:pfam00153   2 ELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSK---GRGILDCFKKIYKEEGIRGLYKGLLPNLLRV 74
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
22-298 9.14e-15

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 73.65  E-value: 9.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542   22 FLLSGCAATVAELATFPLDLTKTRLQMQGeaALAKLGDGAMESapYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVVYS 101
Cdd:PTZ00169  11 FLMGGISAAISKTAVAPIERVKMLIQTQD--SIPEIKSGKVPR--YSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542  102 GGRMVTYEHLREVvFGKSeDEHYPLWK----SVIGGMMAGVIGQFLANPTDLVKVQMQME-GKrrleGKPLRFRGVHHAF 176
Cdd:PTZ00169  87 AFNFAFKDYFKNM-FPKY-NQKTDFWKffgvNILSGGLAGASSLLIVYPLDFARTRLASDiGK----GGDREFTGLFDCL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542  177 AKILAEGGIRGLWAGWIPNIQ-----RAALVNMgdlttYDTVKHYLVLNTAlEDNIATHGLSSLCSGLVASILGTPADVI 251
Cdd:PTZ00169 161 MKISKQTGFLSLYQGFGVSVQgiivyRGAYFGL-----YDSAKALLFGNDK-NTNILYKWAVAQTVTILAGLISYPFDTV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 12055542  252 KSRIMNQPRDKQGRGLLYKSSTDCVIQAVQGEGFLSLYKGFLPSWLR 298
Cdd:PTZ00169 235 RRRMMMMSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLR 281
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
18-163 5.34e-05

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 44.14  E-value: 5.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542   18 RTSKFLLSGCAATV-AELATFPLDLTKTRLQMQGEAAlaklgdgamesapyrgMMRTALGIVQEEGFLK-LWQGVTPAIY 95
Cdd:PTZ00168  83 KTNLYLISTSIAEItACIVRLPFEIVKQNMQVSGNIS----------------VLKTIYEITQREGLPSfLGKSYFVMIV 146
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12055542   96 RHVVYSGGRMVTYEHLREVV---FGKSEdEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRRLE 163
Cdd:PTZ00168 147 REIPFDCIQYFLWETLKEKAkkdFGKFS-KKYPSITSAICGGLAGGIAGFLTTPVDVIKSRQIIYGKSYIE 216
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
233-291 1.43e-03

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 39.91  E-value: 1.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12055542  233 SSLCSGLVASILG---TPADVIKSrimnqprdkqgRGLLYKSSTDCVIQAVQGEGFLSLYKG 291
Cdd:PTZ00168 182 SAICGGLAGGIAGfltTPVDVIKS-----------RQIIYGKSYIETVTEIAEEGYLTFYKG 232
 
Name Accession Description Interval E-value
Mito_carr pfam00153
Mitochondrial carrier protein;
122-218 6.01e-25

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 96.57  E-value: 6.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542   122 EHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRrlegKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAAL 201
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGS----GKSKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAP 76
                          90
                  ....*....|....*..
gi 12055542   202 VNMGDLTTYDTVKHYLV 218
Cdd:pfam00153  77 AAAIYFGTYETLKRLLL 93
Mito_carr pfam00153
Mitochondrial carrier protein;
20-119 4.08e-20

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 83.86  E-value: 4.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542    20 SKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALAKlgdgamesapYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVV 99
Cdd:pfam00153   7 ASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSK----------GRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAP 76
                          90       100
                  ....*....|....*....|
gi 12055542   100 YSGGRMVTYEHLREVVFGKS 119
Cdd:pfam00153  77 AAAIYFGTYETLKRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
224-299 5.49e-16

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 72.30  E-value: 5.49e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12055542   224 EDNIATHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRgllYKSSTDCVIQAVQGEGFLSLYKGFLPSWLRM 299
Cdd:pfam00153   2 ELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSK---GRGILDCFKKIYKEEGIRGLYKGLLPNLLRV 74
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
22-298 9.14e-15

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 73.65  E-value: 9.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542   22 FLLSGCAATVAELATFPLDLTKTRLQMQGeaALAKLGDGAMESapYRGMMRTALGIVQEEGFLKLWQGVTPAIYRHVVYS 101
Cdd:PTZ00169  11 FLMGGISAAISKTAVAPIERVKMLIQTQD--SIPEIKSGKVPR--YSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542  102 GGRMVTYEHLREVvFGKSeDEHYPLWK----SVIGGMMAGVIGQFLANPTDLVKVQMQME-GKrrleGKPLRFRGVHHAF 176
Cdd:PTZ00169  87 AFNFAFKDYFKNM-FPKY-NQKTDFWKffgvNILSGGLAGASSLLIVYPLDFARTRLASDiGK----GGDREFTGLFDCL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542  177 AKILAEGGIRGLWAGWIPNIQ-----RAALVNMgdlttYDTVKHYLVLNTAlEDNIATHGLSSLCSGLVASILGTPADVI 251
Cdd:PTZ00169 161 MKISKQTGFLSLYQGFGVSVQgiivyRGAYFGL-----YDSAKALLFGNDK-NTNILYKWAVAQTVTILAGLISYPFDTV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 12055542  252 KSRIMNQPRDKQGRGLLYKSSTDCVIQAVQGEGFLSLYKGFLPSWLR 298
Cdd:PTZ00169 235 RRRMMMMSGRKAKSEIQYTGTLDCWKKILKNEGLGGFFKGAWANVLR 281
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
18-163 5.34e-05

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 44.14  E-value: 5.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12055542   18 RTSKFLLSGCAATV-AELATFPLDLTKTRLQMQGEAAlaklgdgamesapyrgMMRTALGIVQEEGFLK-LWQGVTPAIY 95
Cdd:PTZ00168  83 KTNLYLISTSIAEItACIVRLPFEIVKQNMQVSGNIS----------------VLKTIYEITQREGLPSfLGKSYFVMIV 146
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 12055542   96 RHVVYSGGRMVTYEHLREVV---FGKSEdEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRRLE 163
Cdd:PTZ00168 147 REIPFDCIQYFLWETLKEKAkkdFGKFS-KKYPSITSAICGGLAGGIAGFLTTPVDVIKSRQIIYGKSYIE 216
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
233-291 1.43e-03

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 39.91  E-value: 1.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12055542  233 SSLCSGLVASILG---TPADVIKSrimnqprdkqgRGLLYKSSTDCVIQAVQGEGFLSLYKG 291
Cdd:PTZ00168 182 SAICGGLAGGIAGfltTPVDVIKS-----------RQIIYGKSYIETVTEIAEEGYLTFYKG 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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